MED28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.41674370
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.77883167
3regulation of translation, ncRNA-mediated (GO:0045974)4.77883167
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.77883167
5proteasome assembly (GO:0043248)4.76771042
6protein deneddylation (GO:0000338)4.43321123
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.37962191
8regulation of gene silencing by RNA (GO:0060966)4.29942745
9regulation of posttranscriptional gene silencing (GO:0060147)4.29942745
10regulation of gene silencing by miRNA (GO:0060964)4.29942745
11ribosomal small subunit assembly (GO:0000028)4.17398642
12behavioral response to nicotine (GO:0035095)4.08337848
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06978605
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.94681740
15rRNA modification (GO:0000154)3.94580242
16pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.93883322
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.93293384
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89580930
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89543123
20cullin deneddylation (GO:0010388)3.79769454
217-methylguanosine mRNA capping (GO:0006370)3.73833015
22mitotic metaphase plate congression (GO:0007080)3.71625853
23chaperone-mediated protein transport (GO:0072321)3.70935318
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65541782
25negative regulation of ligase activity (GO:0051352)3.65541782
26termination of RNA polymerase III transcription (GO:0006386)3.64142840
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.64142840
28RNA capping (GO:0036260)3.63015411
297-methylguanosine RNA capping (GO:0009452)3.63015411
30pyrimidine nucleotide catabolic process (GO:0006244)3.60950085
31neural tube formation (GO:0001841)3.55852824
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52508687
33ribosomal large subunit biogenesis (GO:0042273)3.52198557
34base-excision repair, AP site formation (GO:0006285)3.51401829
35maturation of SSU-rRNA (GO:0030490)3.45176544
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42834328
37regulation of cellular amino acid metabolic process (GO:0006521)3.42735261
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42397392
39positive regulation of ligase activity (GO:0051351)3.40705735
40piRNA metabolic process (GO:0034587)3.37546311
41CENP-A containing nucleosome assembly (GO:0034080)3.36016841
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35401684
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35401684
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35204333
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35204333
46signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35204333
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35039767
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.35039767
49rRNA methylation (GO:0031167)3.33647822
50protein K11-linked ubiquitination (GO:0070979)3.33496293
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.31007112
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25661172
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.25360492
54metallo-sulfur cluster assembly (GO:0031163)3.25074744
55iron-sulfur cluster assembly (GO:0016226)3.25074744
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.24538992
57deoxyribose phosphate biosynthetic process (GO:0046385)3.23063126
582-deoxyribonucleotide biosynthetic process (GO:0009265)3.23063126
59chromatin remodeling at centromere (GO:0031055)3.23018459
60mitochondrial respiratory chain complex assembly (GO:0033108)3.22673866
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22209008
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21312739
63signal transduction involved in DNA damage checkpoint (GO:0072422)3.21312739
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19907624
65regulation of mitochondrial translation (GO:0070129)3.19808738
66signal transduction involved in cell cycle checkpoint (GO:0072395)3.18419695
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.18375302
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18103942
69regulation of mitotic spindle checkpoint (GO:1903504)3.18103942
70transcription-coupled nucleotide-excision repair (GO:0006283)3.17961957
71maturation of 5.8S rRNA (GO:0000460)3.17777326
72viral transcription (GO:0019083)3.17016901
73translational termination (GO:0006415)3.16797161
74DNA double-strand break processing (GO:0000729)3.16630813
75guanosine-containing compound biosynthetic process (GO:1901070)3.16564596
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15659528
77cotranslational protein targeting to membrane (GO:0006613)3.15117504
78ribosomal small subunit biogenesis (GO:0042274)3.14369337
79telomere maintenance via semi-conservative replication (GO:0032201)3.13441506
80DNA replication checkpoint (GO:0000076)3.10793058
81protein targeting to ER (GO:0045047)3.10343525
82regulation of ubiquitin-protein transferase activity (GO:0051438)3.09183086
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.08569736
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08492129
85respiratory chain complex IV assembly (GO:0008535)3.07725725
86deoxyribonucleotide biosynthetic process (GO:0009263)3.07538165
87transcription elongation from RNA polymerase II promoter (GO:0006368)3.06760940
88deoxyribonucleotide catabolic process (GO:0009264)3.05680828
89reciprocal meiotic recombination (GO:0007131)3.04796940
90reciprocal DNA recombination (GO:0035825)3.04796940
91translation (GO:0006412)3.03421359
92metaphase plate congression (GO:0051310)3.01698281
93regulation of ligase activity (GO:0051340)3.01205371
94L-fucose catabolic process (GO:0042355)3.01205034
95fucose catabolic process (GO:0019317)3.01205034
96L-fucose metabolic process (GO:0042354)3.01205034
97DNA strand elongation involved in DNA replication (GO:0006271)3.01142358
98GTP biosynthetic process (GO:0006183)3.00385942
99ncRNA catabolic process (GO:0034661)2.99899224
100establishment of chromosome localization (GO:0051303)2.98220370
101protein localization to endoplasmic reticulum (GO:0070972)2.97765604
102formation of translation preinitiation complex (GO:0001731)2.97678507
103telomere maintenance via recombination (GO:0000722)2.96529302
104translational initiation (GO:0006413)2.96435621
105protein targeting to mitochondrion (GO:0006626)2.95537931
106translational elongation (GO:0006414)2.94690855
107kidney morphogenesis (GO:0060993)2.93751674
108attachment of spindle microtubules to kinetochore (GO:0008608)2.91735141
109ribonucleoprotein complex biogenesis (GO:0022613)2.91106193
110DNA demethylation (GO:0080111)2.90960000
111establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90906353
112interkinetic nuclear migration (GO:0022027)2.89723646
113protein complex biogenesis (GO:0070271)2.89418210
114DNA strand elongation (GO:0022616)2.88961260
115recombinational repair (GO:0000725)2.88550958
116double-strand break repair via homologous recombination (GO:0000724)2.87949076
117protein K6-linked ubiquitination (GO:0085020)2.87297334
118pre-miRNA processing (GO:0031054)2.86866214
119DNA replication-independent nucleosome assembly (GO:0006336)2.86760599
120DNA replication-independent nucleosome organization (GO:0034724)2.86760599
121pseudouridine synthesis (GO:0001522)2.86758725
122spliceosomal snRNP assembly (GO:0000387)2.86060572
123establishment of protein localization to mitochondrion (GO:0072655)2.84663525
124sequestering of actin monomers (GO:0042989)2.84133517
125cytochrome complex assembly (GO:0017004)2.83927839
126rRNA processing (GO:0006364)2.83856921
127ribosome assembly (GO:0042255)2.81054847
128DNA-templated transcription, elongation (GO:0006354)2.80663336
129positive regulation of mRNA catabolic process (GO:0061014)2.80349444
130NADH dehydrogenase complex assembly (GO:0010257)2.79515568
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79515568
132regulation of telomere maintenance (GO:0032204)2.76852994
133positive regulation of mRNA metabolic process (GO:1903313)2.76695496
134meiotic chromosome segregation (GO:0045132)2.76556493
135rRNA catabolic process (GO:0016075)2.75728664
136regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73808678
137positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73808678
138positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.73726584
139regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.73726584
140positive regulation of mRNA processing (GO:0050685)2.72760759
141replication fork processing (GO:0031297)2.71054573
142somatic diversification of immunoglobulins (GO:0016445)2.62704525
143negative regulation of DNA recombination (GO:0045910)2.62648730
144water-soluble vitamin biosynthetic process (GO:0042364)2.61645574
145establishment of protein localization to mitochondrial membrane (GO:0090151)2.57501249
146histone mRNA metabolic process (GO:0008334)2.55357124
147somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53257593
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53257593
149isotype switching (GO:0045190)2.53257593
150synapsis (GO:0007129)2.52532909
151regulation of helicase activity (GO:0051095)2.50787058
152histone exchange (GO:0043486)2.50496247
153regulation of gene silencing (GO:0060968)2.48983873
154somatic diversification of immune receptors (GO:0002200)2.47602055
155somite rostral/caudal axis specification (GO:0032525)2.46332288
156mRNA splice site selection (GO:0006376)2.46039292
157regulation of mesoderm development (GO:2000380)2.44732443
158monoubiquitinated protein deubiquitination (GO:0035520)2.43594689
159positive regulation of histone H3-K4 methylation (GO:0051571)2.42418662
160somatic recombination of immunoglobulin gene segments (GO:0016447)2.41796570
161nucleobase biosynthetic process (GO:0046112)2.41701905
162regulation of histone H3-K9 methylation (GO:0051570)2.40435155
163telomere maintenance via telomerase (GO:0007004)2.40167250
164negative regulation of telomere maintenance (GO:0032205)2.39810687
165negative regulation of histone methylation (GO:0031061)2.39365237
166tryptophan catabolic process (GO:0006569)2.38218531
167indole-containing compound catabolic process (GO:0042436)2.38218531
168indolalkylamine catabolic process (GO:0046218)2.38218531
169intracellular protein transmembrane import (GO:0044743)2.37624995
170regulation of mRNA catabolic process (GO:0061013)2.37575075
171presynaptic membrane assembly (GO:0097105)2.35724975
172nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.33101586
173histone H3-K9 methylation (GO:0051567)2.32812498
174regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.31664136
175somatic cell DNA recombination (GO:0016444)2.31656892
176somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.31656892
177nonmotile primary cilium assembly (GO:0035058)2.30796424
178cytoplasmic mRNA processing body assembly (GO:0033962)2.28852131
179regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28578982
180DNA dealkylation (GO:0035510)2.28547218
181protein localization to cilium (GO:0061512)2.27091304
182somite development (GO:0061053)2.26271101
183DNA modification (GO:0006304)2.25816610
184intra-S DNA damage checkpoint (GO:0031573)2.25159280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48435189
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.32998221
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.04564137
4E2F7_22180533_ChIP-Seq_HELA_Human3.78011481
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.75662991
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68684139
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.62533862
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.47910117
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.40602930
10ZNF274_21170338_ChIP-Seq_K562_Hela3.31871414
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14218312
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11734693
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86714617
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85362171
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.83271088
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79104046
17VDR_22108803_ChIP-Seq_LS180_Human2.70609496
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69633305
19* VDR_23849224_ChIP-Seq_CD4+_Human2.67534630
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65301289
21EWS_26573619_Chip-Seq_HEK293_Human2.64199863
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57496288
23DCP1A_22483619_ChIP-Seq_HELA_Human2.53882403
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52404452
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49529667
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49034306
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45452303
28GABP_19822575_ChIP-Seq_HepG2_Human2.40669973
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37573369
30XRN2_22483619_ChIP-Seq_HELA_Human2.30538017
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30007972
32* SRF_21415370_ChIP-Seq_HL-1_Mouse2.29096054
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23030993
34FUS_26573619_Chip-Seq_HEK293_Human2.22181790
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18686338
36FOXP3_21729870_ChIP-Seq_TREG_Human2.15765991
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15700335
38IRF1_19129219_ChIP-ChIP_H3396_Human2.13114910
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11402622
40NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10348088
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09610623
42POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09132013
43FOXM1_23109430_ChIP-Seq_U2OS_Human2.08114721
44IGF1R_20145208_ChIP-Seq_DFB_Human2.07557659
45FLI1_27457419_Chip-Seq_LIVER_Mouse2.07490151
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07081475
47YY1_21170310_ChIP-Seq_MESCs_Mouse2.01957692
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01840104
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01441580
50TAF15_26573619_Chip-Seq_HEK293_Human2.00503209
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97557460
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97540363
53TTF2_22483619_ChIP-Seq_HELA_Human1.97511607
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88761616
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88739572
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81070428
57ELK1_19687146_ChIP-ChIP_HELA_Human1.80519227
58EZH2_22144423_ChIP-Seq_EOC_Human1.79627802
59P300_19829295_ChIP-Seq_ESCs_Human1.78520597
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78471980
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75305566
62GBX2_23144817_ChIP-Seq_PC3_Human1.74589494
63* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71883073
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71867395
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62619211
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58572331
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57629554
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53504539
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52340419
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50200427
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48521672
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47752010
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.47674810
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46900123
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46850466
76* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45212030
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44974933
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.44476672
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41456310
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41417204
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40900427
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39418066
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.38665189
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35228721
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35228721
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32732072
87MYC_18940864_ChIP-ChIP_HL60_Human1.32573209
88* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31482879
89ER_23166858_ChIP-Seq_MCF-7_Human1.31135782
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30732998
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29233115
92CIITA_25753668_ChIP-Seq_RAJI_Human1.28994554
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27046145
94AR_21909140_ChIP-Seq_LNCAP_Human1.26880823
95KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26122346
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25667709
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.25077365
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24226829
99RNF2_27304074_Chip-Seq_NSC_Mouse1.22085578
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20717000
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19993403
102KDM5A_27292631_Chip-Seq_BREAST_Human1.18761142
103TP53_22573176_ChIP-Seq_HFKS_Human1.18513977
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17560067
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17420776
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16270916
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15758865
108CBP_20019798_ChIP-Seq_JUKART_Human1.14681488
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14681488
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13866055
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13002001
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.11733677
113STAT3_23295773_ChIP-Seq_U87_Human1.11480992
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10957263
115SPI1_23547873_ChIP-Seq_NB4_Human1.10149276
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05521840
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05245542
118TCF4_23295773_ChIP-Seq_U87_Human1.03975025
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03410884
120NANOG_19829295_ChIP-Seq_ESCs_Human1.02889732
121SOX2_19829295_ChIP-Seq_ESCs_Human1.02889732
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02673326
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00810948
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99632268
125* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99598389
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.99161000
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98788307
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98739515
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.97355809
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97168070
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96706105
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95082361
133AR_21572438_ChIP-Seq_LNCaP_Human0.94772591
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.94766885
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.94742512
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94622475
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.93700078
138RUNX2_22187159_ChIP-Seq_PCA_Human0.92705884
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.92597094
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91983539
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91868133
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91866302
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91793339
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.91398421
145DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91153364
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90576057
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90292962
148* TFEB_21752829_ChIP-Seq_HELA_Human0.89703491
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89677802
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.89677802
151SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89386584
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.87200175
153SMAD4_21799915_ChIP-Seq_A2780_Human0.86933599
154REST_21632747_ChIP-Seq_MESCs_Mouse0.85634789
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85570208
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85089274
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84474629
158AR_25329375_ChIP-Seq_VCAP_Human0.84355069
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83201470
160SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83179952
161PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83111708
162TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82815005
163STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80306046
164CTCF_26484167_Chip-Seq_Bcells_Mouse0.80068954
165YY1_22570637_ChIP-Seq_MALME-3M_Human0.79460530
166PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79008078
167* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77083620
168TP63_19390658_ChIP-ChIP_HaCaT_Human0.75763720
169TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69969663
170RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69498856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62862425
2MP0004957_abnormal_blastocyst_morpholog3.68209689
3MP0003718_maternal_effect3.60618471
4MP0010094_abnormal_chromosome_stability3.23963799
5MP0003077_abnormal_cell_cycle2.99555965
6MP0003787_abnormal_imprinting2.97338947
7MP0003111_abnormal_nucleus_morphology2.95834059
8MP0008877_abnormal_DNA_methylation2.72636425
9MP0008058_abnormal_DNA_repair2.59228144
10MP0003646_muscle_fatigue2.51621904
11MP0000569_abnormal_digit_pigmentation2.46729511
12MP0006292_abnormal_olfactory_placode2.44865862
13MP0004147_increased_porphyrin_level2.37435972
14MP0008932_abnormal_embryonic_tissue2.30503746
15MP0003890_abnormal_embryonic-extraembry2.25250822
16MP0003786_premature_aging2.17258265
17MP0008007_abnormal_cellular_replicative2.16948079
18MP0003122_maternal_imprinting2.11476910
19MP0003567_abnormal_fetal_cardiomyocyte2.09583639
20MP0003315_abnormal_perineum_morphology2.06048820
21MP0003123_paternal_imprinting2.05260040
22MP0002102_abnormal_ear_morphology1.94167136
23MP0003763_abnormal_thymus_physiology1.91927828
24MP0003186_abnormal_redox_activity1.89898403
25MP0009379_abnormal_foot_pigmentation1.89288772
26MP0009333_abnormal_splenocyte_physiolog1.85975817
27MP0005671_abnormal_response_to1.84322315
28MP0002938_white_spotting1.84166264
29MP0008995_early_reproductive_senescence1.82597516
30MP0009785_altered_susceptibility_to1.82397916
31MP0002163_abnormal_gland_morphology1.77180349
32MP0005645_abnormal_hypothalamus_physiol1.71141341
33MP0001929_abnormal_gametogenesis1.69583188
34MP0010386_abnormal_urinary_bladder1.69475393
35MP0008260_abnormal_autophagy1.68710878
36MP0001835_abnormal_antigen_presentation1.68459761
37MP0003195_calcinosis1.64652053
38MP0002210_abnormal_sex_determination1.63605503
39MP0001293_anophthalmia1.60012602
40MP0001119_abnormal_female_reproductive1.59015669
41MP0004133_heterotaxia1.56719164
42MP0004142_abnormal_muscle_tone1.56321272
43MP0005451_abnormal_body_composition1.55935068
44MP0003136_yellow_coat_color1.49277405
45MP0000631_abnormal_neuroendocrine_gland1.48451464
46MP0002653_abnormal_ependyma_morphology1.47802186
47MP0000490_abnormal_crypts_of1.45949866
48MP0005084_abnormal_gallbladder_morpholo1.44397894
49MP0000653_abnormal_sex_gland1.43878932
50MP0001986_abnormal_taste_sensitivity1.42607194
51MP0000678_abnormal_parathyroid_gland1.40648352
52MP0001485_abnormal_pinna_reflex1.39659519
53MP0005253_abnormal_eye_physiology1.38134034
54MP0005408_hypopigmentation1.37979744
55MP0005551_abnormal_eye_electrophysiolog1.37669673
56MP0002638_abnormal_pupillary_reflex1.36811778
57MP0003724_increased_susceptibility_to1.36225504
58MP0005389_reproductive_system_phenotype1.35243932
59MP0002148_abnormal_hypersensitivity_rea1.35121238
60MP0006036_abnormal_mitochondrial_physio1.34990959
61MP0009046_muscle_twitch1.31600813
62MP0001919_abnormal_reproductive_system1.31541334
63MP0001145_abnormal_male_reproductive1.31160354
64MP0002160_abnormal_reproductive_system1.30629549
65MP0005395_other_phenotype1.26696860
66MP0001188_hyperpigmentation1.24192713
67MP0003119_abnormal_digestive_system1.22420637
68MP0003937_abnormal_limbs/digits/tail_de1.22029290
69MP0000015_abnormal_ear_pigmentation1.20394465
70MP0002132_abnormal_respiratory_system1.19864559
71MP0002019_abnormal_tumor_incidence1.19155515
72MP0006276_abnormal_autonomic_nervous1.19061946
73MP0003880_abnormal_central_pattern1.19042874
74MP0001529_abnormal_vocalization1.16750151
75MP0004782_abnormal_surfactant_physiolog1.15957522
76MP0001984_abnormal_olfaction1.15767127
77MP0000372_irregular_coat_pigmentation1.14113591
78MP0002398_abnormal_bone_marrow1.13928153
79MP0000313_abnormal_cell_death1.12411930
80MP0005000_abnormal_immune_tolerance1.10192382
81MP0001486_abnormal_startle_reflex1.09950414
82MP0001905_abnormal_dopamine_level1.09606295
83MP0005379_endocrine/exocrine_gland_phen1.09122018
84MP0000778_abnormal_nervous_system1.06310153
85MP0003121_genomic_imprinting1.06030565
86MP0003699_abnormal_female_reproductive1.04379144
87MP0001968_abnormal_touch/_nociception1.04010324
88MP0002723_abnormal_immune_serum1.03882792
89MP0004885_abnormal_endolymph1.02947393
90MP0001819_abnormal_immune_cell1.02317086
91MP0008057_abnormal_DNA_replication1.01686423
92MP0003878_abnormal_ear_physiology1.01607498
93MP0005377_hearing/vestibular/ear_phenot1.01607498
94MP0002420_abnormal_adaptive_immunity1.01602466
95MP0000685_abnormal_immune_system0.99613504
96MP0000689_abnormal_spleen_morphology0.99297612
97MP0001730_embryonic_growth_arrest0.99227958
98MP0000350_abnormal_cell_proliferation0.98653495
99MP0005310_abnormal_salivary_gland0.98196002
100MP0000716_abnormal_immune_system0.98116268
101MP0002405_respiratory_system_inflammati0.97937213
102MP0005025_abnormal_response_to0.97467155
103MP0002751_abnormal_autonomic_nervous0.97347522
104MP0009745_abnormal_behavioral_response0.97211735
105MP0004742_abnormal_vestibular_system0.96234586
106MP0002837_dystrophic_cardiac_calcinosis0.95577980
107MP0005220_abnormal_exocrine_pancreas0.94723758
108MP0002429_abnormal_blood_cell0.93906310
109MP0002452_abnormal_antigen_presenting0.91995501
110MP0002095_abnormal_skin_pigmentation0.91775690
111MP0000358_abnormal_cell_content/0.91613855
112MP0001286_abnormal_eye_development0.91123826
113MP0002722_abnormal_immune_system0.90875912
114MP0000858_altered_metastatic_potential0.90232142
115MP0003938_abnormal_ear_development0.89520339
116MP0000703_abnormal_thymus_morphology0.89418357
117MP0002735_abnormal_chemical_nociception0.88898218
118MP0002693_abnormal_pancreas_physiology0.88719045
119MP0004043_abnormal_pH_regulation0.88541502
120MP0002928_abnormal_bile_duct0.88452689
121MP0001800_abnormal_humoral_immune0.87457834
122MP0005636_abnormal_mineral_homeostasis0.87434289
123MP0005410_abnormal_fertilization0.86999334
124MP0003698_abnormal_male_reproductive0.86161976
125MP0002161_abnormal_fertility/fecundity0.85906893
126MP0003283_abnormal_digestive_organ0.85179285
127MP0008872_abnormal_physiological_respon0.85162895
128MP0002067_abnormal_sensory_capabilities0.85067149
129MP0005174_abnormal_tail_pigmentation0.84648453
130MP0008961_abnormal_basal_metabolism0.84503237
131MP0002736_abnormal_nociception_after0.83516959
132MP0002557_abnormal_social/conspecific_i0.82555920
133MP0005391_vision/eye_phenotype0.81403576
134MP0002254_reproductive_system_inflammat0.81221213
135MP0005075_abnormal_melanosome_morpholog0.80460223
136MP0002396_abnormal_hematopoietic_system0.80210156
137MP0005187_abnormal_penis_morphology0.80185844
138MP0005195_abnormal_posterior_eye0.80132042
139MP0001697_abnormal_embryo_size0.78921521
140MP0005646_abnormal_pituitary_gland0.78710186
141MP0010030_abnormal_orbit_morphology0.77698006
142MP0002277_abnormal_respiratory_mucosa0.77267253
143MP0003943_abnormal_hepatobiliary_system0.75812592
144MP0004145_abnormal_muscle_electrophysio0.75756591
145MP0003861_abnormal_nervous_system0.75717105
146MP0002272_abnormal_nervous_system0.75569064
147MP0000613_abnormal_salivary_gland0.75524923
148MP0002733_abnormal_thermal_nociception0.75487302
149MP0002752_abnormal_somatic_nervous0.74315406
150MP0002009_preneoplasia0.74209925
151MP0005386_behavior/neurological_phenoty0.73058781
152MP0004924_abnormal_behavior0.73058781
153MP0001853_heart_inflammation0.72962933
154MP0009697_abnormal_copulation0.72487183
155MP0004197_abnormal_fetal_growth/weight/0.72340062
156MP0008789_abnormal_olfactory_epithelium0.72210058
157MP0006072_abnormal_retinal_apoptosis0.72083723
158MP0003221_abnormal_cardiomyocyte_apopto0.71811181
159MP0001324_abnormal_eye_pigmentation0.71695020
160MP0002006_tumorigenesis0.71455751
161MP0003436_decreased_susceptibility_to0.71026126
162MP0002084_abnormal_developmental_patter0.71008772
163MP0006082_CNS_inflammation0.70026402
164MP0009703_decreased_birth_body0.67644171
165MP0006035_abnormal_mitochondrial_morpho0.67047451
166MP0002080_prenatal_lethality0.66623430

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)3.99222473
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.99222473
3Aplastic anemia (HP:0001915)3.46254608
4Increased hepatocellular lipid droplets (HP:0006565)3.46223881
5Breast hypoplasia (HP:0003187)3.42801995
6Mitochondrial inheritance (HP:0001427)3.39729135
7Acute necrotizing encephalopathy (HP:0006965)3.33752385
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.33726397
9Birth length less than 3rd percentile (HP:0003561)3.33323759
10Reticulocytopenia (HP:0001896)3.32528549
11Abnormal number of erythroid precursors (HP:0012131)3.30166816
12Hepatocellular necrosis (HP:0001404)3.29630111
13Abnormality of cells of the erythroid lineage (HP:0012130)3.26518199
14Exertional dyspnea (HP:0002875)3.22029029
15Abnormal mitochondria in muscle tissue (HP:0008316)3.14771587
16Lipid accumulation in hepatocytes (HP:0006561)3.11471328
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07706162
18Type I transferrin isoform profile (HP:0003642)3.06305770
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.06020156
20Increased CSF lactate (HP:0002490)3.02603012
21Colon cancer (HP:0003003)3.01921319
22Abnormality of alanine metabolism (HP:0010916)2.99311648
23Hyperalaninemia (HP:0003348)2.99311648
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99311648
25Abnormality of midbrain morphology (HP:0002418)2.95447779
26Molar tooth sign on MRI (HP:0002419)2.95447779
27Premature ovarian failure (HP:0008209)2.95126222
28Oral leukoplakia (HP:0002745)2.91400920
29Hepatic necrosis (HP:0002605)2.91183510
30Nephronophthisis (HP:0000090)2.87433874
31Protruding tongue (HP:0010808)2.86808131
32Secondary amenorrhea (HP:0000869)2.83542987
33Rough bone trabeculation (HP:0100670)2.77513158
34Abnormality of the anterior horn cell (HP:0006802)2.77410636
35Degeneration of anterior horn cells (HP:0002398)2.77410636
36Renal Fanconi syndrome (HP:0001994)2.74996727
37Increased serum lactate (HP:0002151)2.71545387
38Respiratory difficulties (HP:0002880)2.71048980
39Increased intramyocellular lipid droplets (HP:0012240)2.67395138
40Microretrognathia (HP:0000308)2.65983222
41Genetic anticipation (HP:0003743)2.60812128
423-Methylglutaconic aciduria (HP:0003535)2.60013699
43Abnormality of the labia minora (HP:0012880)2.59710162
44Carpal bone hypoplasia (HP:0001498)2.59387413
45Type 2 muscle fiber atrophy (HP:0003554)2.59004937
46Acute encephalopathy (HP:0006846)2.58538629
47Cerebral hypomyelination (HP:0006808)2.57319114
48Patellar aplasia (HP:0006443)2.56141295
49Muscle fiber atrophy (HP:0100295)2.51943507
50Pulmonary fibrosis (HP:0002206)2.50229311
51Aplasia/Hypoplasia of the patella (HP:0006498)2.49302804
52Progressive macrocephaly (HP:0004481)2.45612210
53Abnormality of the renal medulla (HP:0100957)2.43700972
54Poor head control (HP:0002421)2.40130367
55Cleft eyelid (HP:0000625)2.38434555
56Pancreatic cysts (HP:0001737)2.36077681
57Abnormality of the pons (HP:0007361)2.34589748
58Macrocytic anemia (HP:0001972)2.34280096
59Abolished electroretinogram (ERG) (HP:0000550)2.33085390
60Abnormal protein glycosylation (HP:0012346)2.30875984
61Abnormal glycosylation (HP:0012345)2.30875984
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30875984
63Abnormal protein N-linked glycosylation (HP:0012347)2.30875984
64Abnormal trabecular bone morphology (HP:0100671)2.29654142
65Increased muscle lipid content (HP:0009058)2.28758072
66Hypoplasia of the pons (HP:0012110)2.28757509
67Pallor (HP:0000980)2.27626463
68Lactic acidosis (HP:0003128)2.23164747
69Exercise intolerance (HP:0003546)2.22931482
70Abnormality of the preputium (HP:0100587)2.22783919
71Hypoplasia of the fovea (HP:0007750)2.20297958
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.20297958
73Premature graying of hair (HP:0002216)2.19593455
74Pancreatic fibrosis (HP:0100732)2.14013166
75Abnormality of the fovea (HP:0000493)2.13734317
76Meckel diverticulum (HP:0002245)2.12310946
77Abnormality of the renal cortex (HP:0011035)2.11714758
78Neoplasm of the adrenal cortex (HP:0100641)2.10015492
79Broad-based gait (HP:0002136)2.09575274
80Progressive cerebellar ataxia (HP:0002073)2.07802776
81Stomach cancer (HP:0012126)2.07625106
82IgG deficiency (HP:0004315)2.06763084
83Abnormality of renal resorption (HP:0011038)2.05131406
84Intestinal atresia (HP:0011100)2.03677697
85Clumsiness (HP:0002312)2.03517707
86Aplasia/hypoplasia of the uterus (HP:0008684)2.02819349
87Abnormal spermatogenesis (HP:0008669)2.02174033
88Abnormal biliary tract physiology (HP:0012439)2.01138059
89Bile duct proliferation (HP:0001408)2.01138059
90Acute lymphatic leukemia (HP:0006721)2.00503485
91Increased IgM level (HP:0003496)2.00178324
92Congenital stationary night blindness (HP:0007642)1.99359260
93Flat capital femoral epiphysis (HP:0003370)1.98935539
94Medial flaring of the eyebrow (HP:0010747)1.98854549
95Bone marrow hypocellularity (HP:0005528)1.98800194
96Abnormality of the ileum (HP:0001549)1.98598407
97Chronic hepatic failure (HP:0100626)1.98058235
98Anencephaly (HP:0002323)1.98035903
99Bronchiectasis (HP:0002110)1.98004474
100Large for gestational age (HP:0001520)1.96873239
101Male infertility (HP:0003251)1.96429380
102Bilateral microphthalmos (HP:0007633)1.96406101
103Pancytopenia (HP:0001876)1.96347314
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96292126
105Infertility (HP:0000789)1.95219780
106Aplasia/Hypoplasia of the uvula (HP:0010293)1.94703014
107Cystic liver disease (HP:0006706)1.93949105
108True hermaphroditism (HP:0010459)1.93518305
109Respiratory failure (HP:0002878)1.92435716
110Unsteady gait (HP:0002317)1.91494701
111Abnormality of chromosome stability (HP:0003220)1.91129358
112IgM deficiency (HP:0002850)1.90965043
113Hyperventilation (HP:0002883)1.90195779
114Partial agenesis of the corpus callosum (HP:0001338)1.87810604
115Pendular nystagmus (HP:0012043)1.87657207
116Elevated erythrocyte sedimentation rate (HP:0003565)1.86844281
117Type II lissencephaly (HP:0007260)1.85961778
118Furrowed tongue (HP:0000221)1.85713357
119Sclerocornea (HP:0000647)1.85612751
120Homocystinuria (HP:0002156)1.85042015
121Abnormality of homocysteine metabolism (HP:0010919)1.85042015
122Abnormality of magnesium homeostasis (HP:0004921)1.84132114
123Gaze-evoked nystagmus (HP:0000640)1.83547157
124Hyperglycinemia (HP:0002154)1.82457924
125Hyperphosphaturia (HP:0003109)1.81866975
126Hyperglycinuria (HP:0003108)1.81658179
127Chronic bronchitis (HP:0004469)1.81376107
128Dandy-Walker malformation (HP:0001305)1.80661014
129Glycosuria (HP:0003076)1.78744909
130Abnormality of urine glucose concentration (HP:0011016)1.78744909
131Hypergonadotropic hypogonadism (HP:0000815)1.77769187
132Emotional lability (HP:0000712)1.77718985
133Attenuation of retinal blood vessels (HP:0007843)1.76803159
134Methylmalonic acidemia (HP:0002912)1.76796683
135Sloping forehead (HP:0000340)1.76238785
136Abnormal hair whorl (HP:0010721)1.76216994
137Lissencephaly (HP:0001339)1.75550183
13811 pairs of ribs (HP:0000878)1.74073322
139Abnormality of the renal collecting system (HP:0004742)1.74028813
140Absent thumb (HP:0009777)1.73617334
141Chromsome breakage (HP:0040012)1.73505299
142Triphalangeal thumb (HP:0001199)1.72435183
143Hypoplasia of the uterus (HP:0000013)1.72292618
144Septo-optic dysplasia (HP:0100842)1.71916195
145Cerebellar dysplasia (HP:0007033)1.71357665
146Aqueductal stenosis (HP:0002410)1.71002538
147Vaginal atresia (HP:0000148)1.70232235
148Genital tract atresia (HP:0001827)1.67706190
149Congenital primary aphakia (HP:0007707)1.66816656
150Reduced antithrombin III activity (HP:0001976)1.66806114
151Thrombocytosis (HP:0001894)1.66772234
152Ectopic kidney (HP:0000086)1.66716015
153Gait imbalance (HP:0002141)1.66546697
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66360845
155Anophthalmia (HP:0000528)1.62651541
156Inability to walk (HP:0002540)1.62469234
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61657152
158Duplicated collecting system (HP:0000081)1.61615754
159Medulloblastoma (HP:0002885)1.60312660
160Progressive inability to walk (HP:0002505)1.58438031
161Hepatoblastoma (HP:0002884)1.57344501
162Renal cortical cysts (HP:0000803)1.57168907
163Poor coordination (HP:0002370)1.57047956
164Aplasia/Hypoplasia of the spleen (HP:0010451)1.56557237
165Nephrogenic diabetes insipidus (HP:0009806)1.56377356
166Nephroblastoma (Wilms tumor) (HP:0002667)1.56085143
167Congenital, generalized hypertrichosis (HP:0004540)1.54743771
168Stenosis of the external auditory canal (HP:0000402)1.54735715
169Optic nerve hypoplasia (HP:0000609)1.54615442
170Panhypogammaglobulinemia (HP:0003139)1.54242671
171Highly arched eyebrow (HP:0002553)1.53704608
172Supernumerary bones of the axial skeleton (HP:0009144)1.53617837
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.53058152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.79173113
2BUB14.08687127
3STK163.34450468
4PLK43.27739998
5EIF2AK13.27061710
6BRAF2.63542685
7ARAF2.52809122
8TNIK2.47015609
9WEE12.44324228
10INSRR2.31545245
11MAP4K22.14037635
12NME22.13593050
13TESK22.10902850
14ACVR1B2.10780235
15VRK12.03907731
16SRPK11.94039127
17MAP3K121.92961039
18MAP3K41.76190939
19FGFR21.74795149
20TESK11.74629119
21EIF2AK31.72085895
22TTK1.71143760
23DYRK31.70214720
24MUSK1.60879148
25MAPKAPK31.58603323
26BRSK21.55429716
27STK38L1.54363055
28PIM21.52482445
29TLK11.51535357
30GRK11.48089685
31PLK11.46719753
32RPS6KA41.41741582
33PBK1.39854100
34AKT31.33686466
35CASK1.33437372
36CCNB11.32964945
37MOS1.32388906
38NEK21.31061015
39AURKA1.30458227
40DYRK21.29987395
41MAP3K111.29567618
42BMPR21.29278064
43KDR1.28225631
44MAP3K61.21180134
45NME11.18850855
46CDK81.16653151
47TXK1.16340394
48WNK31.16073142
49LIMK11.10504660
50AURKB1.09609106
51TGFBR11.07985735
52CAMK1D1.07103495
53OXSR11.06326791
54CHEK21.05964245
55MST41.05890966
56IKBKE1.05480455
57CDC71.04560665
58VRK21.03346287
59BRSK11.03142525
60TAF10.97809790
61BRD40.94656548
62CAMK1G0.92682544
63PASK0.91155598
64RAF10.90774797
65BMPR1B0.89270921
66NTRK30.89056235
67PLK30.86216986
68BLK0.85249661
69BCR0.85074265
70NLK0.84741242
71TBK10.83986870
72SGK20.83926149
73CSNK1G20.83372241
74ABL20.82280718
75IRAK40.81090879
76CSNK1G10.77559731
77DAPK20.77112845
78NTRK20.76106555
79CDK190.75880989
80JAK30.71782429
81ZAK0.71320720
82IRAK30.70891381
83ZAP700.70756689
84ERBB40.70620819
85FES0.70033170
86EIF2AK20.69793427
87TSSK60.69398208
88NEK90.69262299
89MAP2K70.68694428
90CSNK1A1L0.68549201
91STK30.68167867
92TYK20.68103966
93WNK40.66777589
94ATM0.66680213
95PRKCI0.66617190
96KSR20.63482493
97MAP3K130.61405228
98PRKD30.60749025
99STK40.59840959
100TAOK10.59427808
101PAK10.59067294
102MAP4K10.58893686
103PNCK0.58624255
104PIK3CA0.58122245
105NUAK10.57681443
106STK110.57572590
107DYRK1A0.57495818
108ITK0.57078501
109PINK10.56760748
110CSNK2A10.56523969
111MKNK20.56502206
112CSNK1G30.56383887
113ADRBK10.56272519
114SGK2230.56174072
115SGK4940.56174072
116MAP2K60.55663268
117ATR0.54969808
118SYK0.54861320
119MAPK150.54784965
120RPS6KA50.54602378
121ADRBK20.54114852
122TEC0.53209758
123MAP3K80.52857908
124RPS6KB20.52394395
125BTK0.51034634
126BCKDK0.50889731
127SCYL20.50768756
128PAK30.48870023
129PRKCQ0.48156437
130TAOK30.47368068
131PRKCG0.45433940
132CDK70.44693243
133CAMKK20.44225984
134MAP3K100.43880020
135PIM10.43183668
136MELK0.42157672
137WNK10.42137082
138IRAK10.41937486
139SIK20.41721298
140RIPK40.41548760
141IKBKB0.41445466
142MAP3K50.41252639
143MAPK130.40852895
144MAPKAPK50.40417309
145MATK0.39967438
146MAP3K70.39901130
147MAP2K40.39785745
148KIT0.39636129
149FGR0.39406763
150LYN0.38913384
151YES10.37296390
152CAMK10.36548530
153MAP3K90.35735249
154CDK30.35699032
155LATS10.35425018
156MKNK10.35386875
157TYRO30.35320264

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.46765563
2RNA polymerase_Homo sapiens_hsa030203.80482062
3Ribosome_Homo sapiens_hsa030103.79582201
4DNA replication_Homo sapiens_hsa030303.42144377
5Protein export_Homo sapiens_hsa030602.91116319
6Mismatch repair_Homo sapiens_hsa034302.78731561
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75868379
8Homologous recombination_Homo sapiens_hsa034402.68610707
9Pyrimidine metabolism_Homo sapiens_hsa002402.60967727
10Basal transcription factors_Homo sapiens_hsa030222.50883481
11Nucleotide excision repair_Homo sapiens_hsa034202.42305505
12Base excision repair_Homo sapiens_hsa034102.37478817
13Spliceosome_Homo sapiens_hsa030402.30148702
14RNA transport_Homo sapiens_hsa030132.20326609
15Oxidative phosphorylation_Homo sapiens_hsa001902.15456066
16Cell cycle_Homo sapiens_hsa041102.10593780
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07571453
18RNA degradation_Homo sapiens_hsa030182.04881394
19Selenocompound metabolism_Homo sapiens_hsa004502.02500245
20Phototransduction_Homo sapiens_hsa047442.00509647
21Parkinsons disease_Homo sapiens_hsa050121.91398296
22Fanconi anemia pathway_Homo sapiens_hsa034601.76076769
23Huntingtons disease_Homo sapiens_hsa050161.74250610
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71428431
25Butanoate metabolism_Homo sapiens_hsa006501.71059833
26Nicotine addiction_Homo sapiens_hsa050331.61856256
27Purine metabolism_Homo sapiens_hsa002301.59562601
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52345902
29Propanoate metabolism_Homo sapiens_hsa006401.51339620
30Nitrogen metabolism_Homo sapiens_hsa009101.37936741
31Folate biosynthesis_Homo sapiens_hsa007901.36180752
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35064291
33Taste transduction_Homo sapiens_hsa047421.27103908
34p53 signaling pathway_Homo sapiens_hsa041151.26457564
35Other glycan degradation_Homo sapiens_hsa005111.25732744
36Non-homologous end-joining_Homo sapiens_hsa034501.25715010
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23343973
38Epstein-Barr virus infection_Homo sapiens_hsa051691.17458416
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16533027
40Alzheimers disease_Homo sapiens_hsa050101.12564205
41Peroxisome_Homo sapiens_hsa041461.05872334
42Primary immunodeficiency_Homo sapiens_hsa053401.01604514
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01038428
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97478390
45Oocyte meiosis_Homo sapiens_hsa041140.96980903
46Olfactory transduction_Homo sapiens_hsa047400.92907976
47Allograft rejection_Homo sapiens_hsa053300.92259436
48Antigen processing and presentation_Homo sapiens_hsa046120.89362809
49Vitamin B6 metabolism_Homo sapiens_hsa007500.88809154
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88587425
51Regulation of autophagy_Homo sapiens_hsa041400.87455950
52Herpes simplex infection_Homo sapiens_hsa051680.86485496
53mRNA surveillance pathway_Homo sapiens_hsa030150.84765039
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84585062
55Vitamin digestion and absorption_Homo sapiens_hsa049770.83359446
56Tryptophan metabolism_Homo sapiens_hsa003800.81945833
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78204574
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77721182
59Legionellosis_Homo sapiens_hsa051340.74366448
60Arachidonic acid metabolism_Homo sapiens_hsa005900.74010130
61Type I diabetes mellitus_Homo sapiens_hsa049400.74008609
62Vibrio cholerae infection_Homo sapiens_hsa051100.73705094
63Shigellosis_Homo sapiens_hsa051310.73384090
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.73180385
65Graft-versus-host disease_Homo sapiens_hsa053320.72783154
66Morphine addiction_Homo sapiens_hsa050320.72410999
67Collecting duct acid secretion_Homo sapiens_hsa049660.72169057
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71408790
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70156284
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.70094912
71Lysine degradation_Homo sapiens_hsa003100.68103868
72Asthma_Homo sapiens_hsa053100.67832723
73N-Glycan biosynthesis_Homo sapiens_hsa005100.67094760
74Serotonergic synapse_Homo sapiens_hsa047260.66850222
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65901911
76Circadian entrainment_Homo sapiens_hsa047130.65427653
77One carbon pool by folate_Homo sapiens_hsa006700.65136855
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64902262
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64149609
80Sulfur relay system_Homo sapiens_hsa041220.63197695
81Basal cell carcinoma_Homo sapiens_hsa052170.62647363
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62009594
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61436181
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60906891
85Measles_Homo sapiens_hsa051620.58692341
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58207606
87Circadian rhythm_Homo sapiens_hsa047100.56300452
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55981458
89Pentose phosphate pathway_Homo sapiens_hsa000300.55267879
90Rheumatoid arthritis_Homo sapiens_hsa053230.54372025
91Linoleic acid metabolism_Homo sapiens_hsa005910.54306602
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54142341
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50695432
94Sphingolipid metabolism_Homo sapiens_hsa006000.50329777
95Glutathione metabolism_Homo sapiens_hsa004800.49989617
96Glutamatergic synapse_Homo sapiens_hsa047240.49661670
97GABAergic synapse_Homo sapiens_hsa047270.48383858
98Dorso-ventral axis formation_Homo sapiens_hsa043200.48154456
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47969100
100Wnt signaling pathway_Homo sapiens_hsa043100.47578470
101Type II diabetes mellitus_Homo sapiens_hsa049300.46280247
102Influenza A_Homo sapiens_hsa051640.44370279
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43706176
104Hedgehog signaling pathway_Homo sapiens_hsa043400.43698519
105Insulin secretion_Homo sapiens_hsa049110.42194028
106Long-term depression_Homo sapiens_hsa047300.41591445
107Steroid biosynthesis_Homo sapiens_hsa001000.41484649
108HTLV-I infection_Homo sapiens_hsa051660.40878451
109Hematopoietic cell lineage_Homo sapiens_hsa046400.39932150
110Metabolic pathways_Homo sapiens_hsa011000.39294726
111Autoimmune thyroid disease_Homo sapiens_hsa053200.39233293
112Colorectal cancer_Homo sapiens_hsa052100.38715229
113Hepatitis B_Homo sapiens_hsa051610.37777922
114Leishmaniasis_Homo sapiens_hsa051400.37248606
115Viral carcinogenesis_Homo sapiens_hsa052030.34991403
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34702285
117Alcoholism_Homo sapiens_hsa050340.34270785
118Fructose and mannose metabolism_Homo sapiens_hsa000510.34076796
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.33932324
120Cardiac muscle contraction_Homo sapiens_hsa042600.33158024
121Apoptosis_Homo sapiens_hsa042100.32449912
122Calcium signaling pathway_Homo sapiens_hsa040200.31860421
123Cholinergic synapse_Homo sapiens_hsa047250.31821092
124ABC transporters_Homo sapiens_hsa020100.31357814
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30747697
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30514192
127Galactose metabolism_Homo sapiens_hsa000520.29525431
128Thyroid cancer_Homo sapiens_hsa052160.28487874
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28282746
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.27184483
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25642500
132Lysosome_Homo sapiens_hsa041420.25240199
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24685209
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24642769
135Phagosome_Homo sapiens_hsa041450.22021908
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.21991482
137Ether lipid metabolism_Homo sapiens_hsa005650.21370654
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21313266
139Systemic lupus erythematosus_Homo sapiens_hsa053220.19973199
140Prolactin signaling pathway_Homo sapiens_hsa049170.16884276
141Pertussis_Homo sapiens_hsa051330.13478209
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13283228
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12925270
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11317930

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