ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proline biosynthetic process (GO:0006561)	8.33810386
2	inner mitochondrial membrane organization (GO:0007007)	7.84468052
3	receptor catabolic process (GO:0032801)	7.29390295
4	dorsal/ventral axis specification (GO:0009950)	6.73120592
5	attachment of spindle microtubules to kinetochore (GO:0008608)	6.35036462
6	proline metabolic process (GO:0006560)	6.15725685
7	righting reflex (GO:0060013)	6.11521270
8	CDP-diacylglycerol biosynthetic process (GO:0016024)	5.78108237
9	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	5.50033264
10	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	5.50033264
11	estrogen biosynthetic process (GO:0006703)	5.11869674
12	CDP-diacylglycerol metabolic process (GO:0046341)	4.87148117
13	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.81563638
14	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.74318612
15	mitochondrial fusion (GO:0008053)	4.59832573
16	cullin deneddylation (GO:0010388)	4.59513144
17	peptidyl-cysteine modification (GO:0018198)	4.50578313
18	toxin metabolic process (GO:0009404)	4.45938961
19	single strand break repair (GO:0000012)	4.44615219
20	snRNA transcription (GO:0009301)	4.38536762
21	nonmotile primary cilium assembly (GO:0035058)	4.36998372
22	regulation of acyl-CoA biosynthetic process (GO:0050812)	4.33084704
23	glycosphingolipid biosynthetic process (GO:0006688)	4.32960561
24	protein deneddylation (GO:0000338)	4.30335568
25	organelle membrane fusion (GO:0090174)	4.20426844
26	response to pheromone (GO:0019236)	4.15147723
27	detection of calcium ion (GO:0005513)	4.14159172
28	transcription from mitochondrial promoter (GO:0006390)	4.08535482
29	regulation of cofactor metabolic process (GO:0051193)	4.01263723
30	regulation of coenzyme metabolic process (GO:0051196)	4.01263723
31	photoreceptor cell differentiation (GO:0046530)	3.99046336
32	eye photoreceptor cell differentiation (GO:0001754)	3.99046336
33	potassium ion export (GO:0071435)	3.98331479
34	ovulation from ovarian follicle (GO:0001542)	3.94332880
35	glycosylceramide metabolic process (GO:0006677)	3.85799591
36	iron ion import (GO:0097286)	3.85339230
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.81640251
38	peptidyl-histidine modification (GO:0018202)	3.77392409
39	vascular smooth muscle contraction (GO:0014829)	3.75243978
40	amino acid salvage (GO:0043102)	3.71740183
41	L-methionine salvage (GO:0071267)	3.71740183
42	L-methionine biosynthetic process (GO:0071265)	3.71740183
43	regulation of sulfur metabolic process (GO:0042762)	3.70937212
44	signal peptide processing (GO:0006465)	3.69655747
45	epithelial cell fate commitment (GO:0072148)	3.61859995
46	regulation of DNA endoreduplication (GO:0032875)	3.56301359
47	mRNA cleavage (GO:0006379)	3.54356049
48	natural killer cell activation involved in immune response (GO:0002323)	3.49292487
49	protein localization to Golgi apparatus (GO:0034067)	3.46387118
50	brain morphogenesis (GO:0048854)	3.45867452
51	response to methylmercury (GO:0051597)	3.39548669
52	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.38854893
53	kidney morphogenesis (GO:0060993)	3.37828029
54	renal tubule development (GO:0061326)	3.35521792
55	cellular response to gamma radiation (GO:0071480)	3.34262804
56	tRNA methylation (GO:0030488)	3.32948453
57	regulation of MHC class I biosynthetic process (GO:0045343)	3.24578186
58	regulation of mitochondrial translation (GO:0070129)	3.23618482
59	ribonucleoprotein complex disassembly (GO:0032988)	3.23445623
60	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.14895929
61	nitric oxide metabolic process (GO:0046209)	3.14393843
62	metanephric mesenchyme development (GO:0072075)	3.12470122
63	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.11551289
64	L-phenylalanine catabolic process (GO:0006559)	3.11551289
65	mRNA modification (GO:0016556)	3.11152182
66	protein palmitoylation (GO:0018345)	3.09301163
67	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.08691547
68	microtubule anchoring (GO:0034453)	3.06157276
69	histone H2A acetylation (GO:0043968)	3.05321978
70	endosome to lysosome transport (GO:0008333)	3.03053559
71	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.97516230
72	atrial cardiac muscle cell action potential (GO:0086014)	2.96959125
73	positive regulation of cytokinesis (GO:0032467)	2.96116794
74	autophagic vacuole fusion (GO:0000046)	2.91478014
75	histone H2A monoubiquitination (GO:0035518)	2.90744467
76	mitotic spindle checkpoint (GO:0071174)	2.89646844
77	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.87634081
78	DNA double-strand break processing (GO:0000729)	2.87115118
79	reflex (GO:0060004)	2.84510830
80	methionine biosynthetic process (GO:0009086)	2.83507976
81	translesion synthesis (GO:0019985)	2.83422639
82	negative regulation of mRNA processing (GO:0050686)	2.83386016
83	regulation of clathrin-mediated endocytosis (GO:2000369)	2.80761924
84	positive regulation of cell fate commitment (GO:0010455)	2.79249234
85	succinate metabolic process (GO:0006105)	2.78050406
86	proteasome assembly (GO:0043248)	2.77800041
87	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.74476069
88	spindle checkpoint (GO:0031577)	2.73777479
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70159192
90	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.69946486
91	import into cell (GO:0098657)	2.68245933
92	Sertoli cell development (GO:0060009)	2.68074856
93	protein K11-linked deubiquitination (GO:0035871)	2.67487087
94	kidney mesenchyme development (GO:0072074)	2.67363459
95	prenylation (GO:0097354)	2.65276370
96	protein prenylation (GO:0018342)	2.65276370
97	chaperone-mediated protein transport (GO:0072321)	2.64882061
98	thalamus development (GO:0021794)	2.62161623
99	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.60580602
100	mitochondrial RNA metabolic process (GO:0000959)	2.60406754

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.87248064
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.08780401
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.66469601
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.24747188
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.23476528
6	E2F7_22180533_ChIP-Seq_HELA_Human	2.84443610
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.57133454
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.56147529
9	FUS_26573619_Chip-Seq_HEK293_Human	2.47886132
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.47582686
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39282181
12	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.09126800
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.08254557
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.06676959
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.04353339
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98673844
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.97511114
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.97507217
19	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.96457740
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87139422
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.87132579
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85008274
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.79994270
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69439053
25	VDR_22108803_ChIP-Seq_LS180_Human	1.67620838
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66647810
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66116673
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.65559815
29	P300_19829295_ChIP-Seq_ESCs_Human	1.64645170
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63342805
31	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.62645364
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.60375252
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.59061200
34	EWS_26573619_Chip-Seq_HEK293_Human	1.55965652
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.54197638
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.53651018
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53495158
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.52654925
39	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.45637151
40	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.45328075
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41341197
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.40451988
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40219487
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.39775296
45	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.39445611
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38030435
47	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.34683520
48	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.34427258
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33095081
50	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32348412
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31103321
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30524135
53	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.30387082
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29308775
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.28417679
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28397265
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26506642
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26405547
59	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25084073
60	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.23841032
61	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.18965116
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18912905
63	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.18540441
64	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.17272186
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.16952040
66	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.13619076
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.13591149
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10009747
69	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.09179203
70	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.08072317
71	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.06794789
72	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.05693850
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05419222
74	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.05200168
75	STAT3_23295773_ChIP-Seq_U87_Human	1.04674182
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.04565005
77	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.03731061
78	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03640629
79	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03401665
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03376719
81	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03140020
82	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99527299
83	P300_18555785_Chip-Seq_ESCs_Mouse	0.99056196
84	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.98079507
85	TFEB_21752829_ChIP-Seq_HELA_Human	0.97650382
86	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96071626
87	GBX2_23144817_ChIP-Seq_PC3_Human	0.96056137
88	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.94051430
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92974953
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92380542
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92380542
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.91639442
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91450359
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91000193
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90589825
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.90574683
97	AR_25329375_ChIP-Seq_VCAP_Human	0.90270445
98	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.90021957
99	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.89953211
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.89438258

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.71408538
2	MP0002638_abnormal_pupillary_reflex	4.13688433
3	MP0010234_abnormal_vibrissa_follicle	3.94590331
4	MP0010678_abnormal_skin_adnexa	3.82027005
5	MP0000383_abnormal_hair_follicle	3.79043900
6	MP0003011_delayed_dark_adaptation	3.78353659
7	MP0003283_abnormal_digestive_organ	3.65120422
8	MP0010094_abnormal_chromosome_stability	2.96491083
9	MP0000427_abnormal_hair_cycle	2.90704005
10	MP0002837_dystrophic_cardiac_calcinosis	2.88704527
11	MP0005220_abnormal_exocrine_pancreas	2.88157942
12	MP0002877_abnormal_melanocyte_morpholog	2.72441857
13	MP0003941_abnormal_skin_development	2.65327172
14	MP0001984_abnormal_olfaction	2.45528923
15	MP0008058_abnormal_DNA_repair	2.42589549
16	MP0006292_abnormal_olfactory_placode	2.40984000
17	MP0008995_early_reproductive_senescence	1.97404215
18	MP0002139_abnormal_hepatobiliary_system	1.91432418
19	MP0008789_abnormal_olfactory_epithelium	1.88717681
20	MP0008007_abnormal_cellular_replicative	1.86556052
21	MP0000013_abnormal_adipose_tissue	1.86448067
22	MP0002090_abnormal_vision	1.85916570
23	MP0003786_premature_aging	1.85683276
24	MP0000647_abnormal_sebaceous_gland	1.83128709
25	MP0005379_endocrine/exocrine_gland_phen	1.82672385
26	MP0003195_calcinosis	1.81347793
27	MP0005645_abnormal_hypothalamus_physiol	1.75035702
28	MP0002163_abnormal_gland_morphology	1.66322028
29	MP0001529_abnormal_vocalization	1.65029634
30	MP0009046_muscle_twitch	1.57809633
31	MP0006054_spinal_hemorrhage	1.55652140
32	MP0005394_taste/olfaction_phenotype	1.50908626
33	MP0005499_abnormal_olfactory_system	1.50908626
34	MP0003693_abnormal_embryo_hatching	1.50519022
35	MP0006035_abnormal_mitochondrial_morpho	1.49078086
36	MP0002938_white_spotting	1.48234551
37	MP0004957_abnormal_blastocyst_morpholog	1.47333245
38	MP0005365_abnormal_bile_salt	1.38203824
39	MP0003787_abnormal_imprinting	1.38167050
40	MP0006072_abnormal_retinal_apoptosis	1.37984446
41	MP0008877_abnormal_DNA_methylation	1.32976324
42	MP0001727_abnormal_embryo_implantation	1.30919015
43	MP0003252_abnormal_bile_duct	1.30225629
44	MP0000003_abnormal_adipose_tissue	1.26635582
45	MP0005253_abnormal_eye_physiology	1.24767060
46	MP0002693_abnormal_pancreas_physiology	1.22515357
47	MP0004147_increased_porphyrin_level	1.17280517
48	MP0001286_abnormal_eye_development	1.15474655
49	MP0004043_abnormal_pH_regulation	1.13326804
50	MP0003718_maternal_effect	1.12294027
51	MP0002009_preneoplasia	1.11841093
52	MP0001485_abnormal_pinna_reflex	1.09025037
53	MP0004885_abnormal_endolymph	1.08462156
54	MP0010307_abnormal_tumor_latency	1.07093585
55	MP0001944_abnormal_pancreas_morphology	1.06055723
56	MP0003937_abnormal_limbs/digits/tail_de	1.03065934
57	MP0002102_abnormal_ear_morphology	1.01579217
58	MP0001293_anophthalmia	0.98256915
59	MP0001929_abnormal_gametogenesis	0.97967157
60	MP0005257_abnormal_intraocular_pressure	0.97184959
61	MP0001188_hyperpigmentation	0.94921573
62	MP0006036_abnormal_mitochondrial_physio	0.93715704
63	MP0004085_abnormal_heartbeat	0.92709560
64	MP0010352_gastrointestinal_tract_polyps	0.91235587
65	MP0003111_abnormal_nucleus_morphology	0.90549112
66	MP0002876_abnormal_thyroid_physiology	0.90461896
67	MP0009765_abnormal_xenobiotic_induced	0.90164602
68	MP0000613_abnormal_salivary_gland	0.89566858
69	MP0004133_heterotaxia	0.86629569
70	MP0005248_abnormal_Harderian_gland	0.80074003
71	MP0001501_abnormal_sleep_pattern	0.79051207
72	MP0009780_abnormal_chondrocyte_physiolo	0.76436194
73	MP0005408_hypopigmentation	0.76154314
74	MP0005085_abnormal_gallbladder_physiolo	0.75847741
75	MP0002078_abnormal_glucose_homeostasis	0.73981906
76	MP0001145_abnormal_male_reproductive	0.72111606
77	MP0002210_abnormal_sex_determination	0.71382915
78	MP0005391_vision/eye_phenotype	0.71193865
79	MP0000516_abnormal_urinary_system	0.70591880
80	MP0005367_renal/urinary_system_phenotyp	0.70591880
81	MP0002697_abnormal_eye_size	0.70356158
82	MP0005551_abnormal_eye_electrophysiolog	0.70336956
83	MP0000653_abnormal_sex_gland	0.70224384
84	MP0005389_reproductive_system_phenotype	0.69983161
85	MP0010386_abnormal_urinary_bladder	0.69368029
86	MP0001730_embryonic_growth_arrest	0.65611864
87	MP0005195_abnormal_posterior_eye	0.65010863
88	MP0003077_abnormal_cell_cycle	0.63628538
89	MP0009703_decreased_birth_body	0.62812339
90	MP0001919_abnormal_reproductive_system	0.61520101
91	MP0005310_abnormal_salivary_gland	0.58083785
92	MP0001191_abnormal_skin_condition	0.57584459
93	MP0002295_abnormal_pulmonary_circulatio	0.57205115
94	MP0002254_reproductive_system_inflammat	0.56533393
95	MP0001697_abnormal_embryo_size	0.54609964
96	MP0001119_abnormal_female_reproductive	0.53336872
97	MP0001764_abnormal_homeostasis	0.52714699
98	MP0004134_abnormal_chest_morphology	0.48477430
99	MP0010329_abnormal_lipoprotein_level	0.48331799
100	MP0009745_abnormal_behavioral_response	0.47294347

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gaze-evoked nystagmus (HP:0000640)	6.68565259
2	Increased intramyocellular lipid droplets (HP:0012240)	5.57706417
3	Medial flaring of the eyebrow (HP:0010747)	5.14539299
4	Dysmetric saccades (HP:0000641)	5.11840417
5	Pancreatic islet-cell hyperplasia (HP:0004510)	4.88887021
6	Renal Fanconi syndrome (HP:0001994)	4.84041387
7	Abnormality of alanine metabolism (HP:0010916)	4.81701067
8	Hyperalaninemia (HP:0003348)	4.81701067
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.81701067
10	Increased muscle lipid content (HP:0009058)	4.79647562
11	Increased hepatocellular lipid droplets (HP:0006565)	4.58367111
12	Lipid accumulation in hepatocytes (HP:0006561)	4.31960512
13	Progressive external ophthalmoplegia (HP:0000590)	3.80668229
14	Coronal craniosynostosis (HP:0004440)	3.68229479
15	Large for gestational age (HP:0001520)	3.44263935
16	Congenital primary aphakia (HP:0007707)	3.36770504
17	Sensorimotor neuropathy (HP:0007141)	3.34004632
18	Male infertility (HP:0003251)	3.27733489
19	Gait imbalance (HP:0002141)	3.26970573
20	Spastic paraparesis (HP:0002313)	3.21776077
21	Hydroureter (HP:0000072)	3.19968301
22	Limb ataxia (HP:0002070)	3.13737096
23	Zonular cataract (HP:0010920)	3.07401409
24	Abnormality of renal resorption (HP:0011038)	3.07135963
25	Supernumerary spleens (HP:0009799)	3.03765111
26	Abnormal rod and cone electroretinograms (HP:0008323)	3.01072490
27	Attenuation of retinal blood vessels (HP:0007843)	2.98013213
28	Nephrogenic diabetes insipidus (HP:0009806)	2.85337965
29	Exertional dyspnea (HP:0002875)	2.82744036
30	Abnormality of the pancreatic islet cells (HP:0006476)	2.71090289
31	Abnormality of endocrine pancreas physiology (HP:0012093)	2.71090289
32	Intestinal atresia (HP:0011100)	2.67557323
33	Hypomagnesemia (HP:0002917)	2.62832771
34	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.60036089
35	Dysdiadochokinesis (HP:0002075)	2.59449892
36	Poor coordination (HP:0002370)	2.56487614
37	Short foot (HP:0001773)	2.55124894
38	Ankyloglossia (HP:0010296)	2.53140738
39	Disproportionate short-trunk short stature (HP:0003521)	2.50918805
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46357548
41	Oculomotor apraxia (HP:0000657)	2.38468132
42	Lower limb hyperreflexia (HP:0002395)	2.28573231
43	Abnormality of saccadic eye movements (HP:0000570)	2.28268842
44	Hyperphosphaturia (HP:0003109)	2.26148172
45	Mitochondrial inheritance (HP:0001427)	2.24907841
46	Vaginal atresia (HP:0000148)	2.24441585
47	Persistence of primary teeth (HP:0006335)	2.23618434
48	Genital tract atresia (HP:0001827)	2.23590032
49	Barrel-shaped chest (HP:0001552)	2.21336446
50	Abnormality of oral frenula (HP:0000190)	2.14879441
51	Bony spicule pigmentary retinopathy (HP:0007737)	2.14418923
52	Hypophosphatemic rickets (HP:0004912)	2.12839842
53	Tubulointerstitial nephritis (HP:0001970)	2.11361067
54	Glycosuria (HP:0003076)	2.10824704
55	Abnormality of urine glucose concentration (HP:0011016)	2.10824704
56	Confusion (HP:0001289)	2.10040527
57	Diaphragmatic weakness (HP:0009113)	2.07871394
58	Glossoptosis (HP:0000162)	2.05683662
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04922762
60	Abnormality of the parathyroid morphology (HP:0011766)	2.04707790
61	Palpitations (HP:0001962)	2.03723431
62	Progressive macrocephaly (HP:0004481)	2.02719555
63	Aplasia/Hypoplasia of the lens (HP:0008063)	2.02045204
64	Double outlet right ventricle (HP:0001719)	2.00937020
65	Congenital malformation of the right heart (HP:0011723)	2.00937020
66	Dyschromatopsia (HP:0007641)	2.00658714
67	Acute necrotizing encephalopathy (HP:0006965)	1.95714016
68	Volvulus (HP:0002580)	1.95679696
69	Horizontal nystagmus (HP:0000666)	1.95386338
70	Septate vagina (HP:0001153)	1.94785520
71	Termporal pattern (HP:0011008)	1.94675118
72	Insidious onset (HP:0003587)	1.94675118
73	Increased CSF lactate (HP:0002490)	1.91747738
74	Central scotoma (HP:0000603)	1.88973030
75	Generalized myoclonic seizures (HP:0002123)	1.85903947
76	Renal tubular dysfunction (HP:0000124)	1.85257257
77	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.84952826
78	Abnormality of magnesium homeostasis (HP:0004921)	1.84317487
79	Large eyes (HP:0001090)	1.83037168
80	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.82956470
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.82956470
82	Ileus (HP:0002595)	1.82748873
83	Duplicated collecting system (HP:0000081)	1.82303253
84	Aqueductal stenosis (HP:0002410)	1.81851927
85	Respiratory difficulties (HP:0002880)	1.81711597
86	Nuclear cataract (HP:0100018)	1.81069109
87	Leukodystrophy (HP:0002415)	1.80610164
88	Urethral obstruction (HP:0000796)	1.78717511
89	Abnormal mitochondria in muscle tissue (HP:0008316)	1.77553235
90	Gait ataxia (HP:0002066)	1.76900094
91	Slow saccadic eye movements (HP:0000514)	1.75604900
92	Hypothermia (HP:0002045)	1.72509423
93	Broad-based gait (HP:0002136)	1.72238608
94	Abnormal urine phosphate concentration (HP:0012599)	1.71923788
95	Increased circulating renin level (HP:0000848)	1.69485497
96	Intention tremor (HP:0002080)	1.68110598
97	Abnormality of methionine metabolism (HP:0010901)	1.66628438
98	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.64749768
99	Prominent supraorbital ridges (HP:0000336)	1.64619711
100	11 pairs of ribs (HP:0000878)	1.64193729

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	9.91633106
2	ACVR1B	5.46333614
3	ERBB3	4.70021010
4	FRK	4.07309325
5	BMPR2	3.99117129
6	FGFR2	2.40948451
7	MAP3K4	2.31443859
8	FGR	2.03984801
9	MAP3K9	2.01542554
10	SGK2	1.79835099
11	MAP3K13	1.67881975
12	PTK2B	1.58273926
13	SGK3	1.54312609
14	CSNK1G1	1.41556721
15	ARAF	1.39568501
16	NLK	1.37206107
17	TRPM7	1.31554159
18	TSSK6	1.27458871
19	DAPK2	1.22625458
20	SGK223	1.21442793
21	SGK494	1.21442793
22	KSR2	1.17347198
23	SIK2	1.10178846
24	CLK1	1.08964426
25	MAPK11	1.05760792
26	TNIK	1.01160278
27	AKT3	0.93708563
28	CDC7	0.93241947
29	BRAF	0.89149370
30	STK4	0.87371337
31	MKNK2	0.86032387
32	RAF1	0.85214064
33	PRKD2	0.77563807
34	FGFR3	0.76907961
35	TEC	0.75387972
36	PRKCH	0.74363419
37	MST4	0.72088998
38	NTRK3	0.71192895
39	BMPR1B	0.71136588
40	WNK3	0.69756346
41	IKBKE	0.69589406
42	CDK3	0.68083013
43	TTK	0.63749811
44	ADRBK2	0.63560054
45	TAOK3	0.62101987
46	PLK3	0.61042563
47	BUB1	0.59577328
48	ITK	0.59364799
49	OXSR1	0.58195114
50	CHEK2	0.57185763
51	SGK1	0.56154170
52	KSR1	0.55358912
53	PLK1	0.53198313
54	STK39	0.52477453
55	RPS6KB2	0.50470574
56	MOS	0.49683928
57	TNK2	0.47923710
58	ATR	0.47443536
59	PRKCE	0.47167216
60	DYRK3	0.46088623
61	PLK2	0.45891571
62	GSK3A	0.41766677
63	TAOK1	0.40969272
64	NEK1	0.40200665
65	MKNK1	0.35793497
66	PIM1	0.35364762
67	NUAK1	0.31891651
68	DAPK1	0.31592401
69	ZAK	0.31307899
70	PRKACB	0.30382417
71	HIPK2	0.29154432
72	CHEK1	0.28930768
73	FER	0.28353425
74	NEK2	0.27256375
75	GRK1	0.26786355
76	STK38L	0.26220596
77	PRKG1	0.25558260
78	ATM	0.24868916
79	CDK4	0.24598196
80	FGFR4	0.23776782
81	CDK15	0.23506838
82	CSNK1G3	0.22646860
83	MAP3K12	0.21927617
84	CDK18	0.20879437
85	CDK11A	0.20068966
86	CHUK	0.18918332
87	CSNK1E	0.18298852
88	CSNK1A1L	0.17861376
89	ABL2	0.17588455
90	MAP2K1	0.16112966
91	DYRK2	0.15990789
92	PINK1	0.15870007
93	PRKCI	0.15645593
94	CDK6	0.14960861
95	PRKCG	0.14930043
96	CSNK1D	0.14873163
97	CAMK2D	0.14771541
98	CAMK1G	0.13912465
99	WNK1	0.13809725
100	CSNK2A2	0.13138305

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.94262877
2	Protein export_Homo sapiens_hsa03060	3.96979806
3	Basal transcription factors_Homo sapiens_hsa03022	3.35705579
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.44949210
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.39815617
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.36318588
7	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.22777474
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.15311013
9	Sulfur metabolism_Homo sapiens_hsa00920	2.13391592
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.12817168
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04666388
12	Proteasome_Homo sapiens_hsa03050	1.99390077
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.91714872
14	Butanoate metabolism_Homo sapiens_hsa00650	1.91329964
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84117152
16	Insulin secretion_Homo sapiens_hsa04911	1.81584130
17	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.80694326
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.75606558
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.73620144
20	RNA polymerase_Homo sapiens_hsa03020	1.70008254
21	Propanoate metabolism_Homo sapiens_hsa00640	1.67008154
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53076867
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.51668938
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50967762
25	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.47187816
26	Mismatch repair_Homo sapiens_hsa03430	1.44702423
27	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.38834177
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35408112
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31757456
30	Retinol metabolism_Homo sapiens_hsa00830	1.24213946
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.20900558
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.14327969
33	RNA degradation_Homo sapiens_hsa03018	1.12979294
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10893912
35	One carbon pool by folate_Homo sapiens_hsa00670	1.07740721
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06908979
37	Taste transduction_Homo sapiens_hsa04742	1.06881240
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03949096
39	Phototransduction_Homo sapiens_hsa04744	1.03341971
40	DNA replication_Homo sapiens_hsa03030	1.02939406
41	Sphingolipid metabolism_Homo sapiens_hsa00600	1.01079753
42	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96932754
43	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.94324138
44	RNA transport_Homo sapiens_hsa03013	0.92046281
45	Vibrio cholerae infection_Homo sapiens_hsa05110	0.88898472
46	Homologous recombination_Homo sapiens_hsa03440	0.87178140
47	Cell cycle_Homo sapiens_hsa04110	0.86702329
48	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.86031935
49	Mineral absorption_Homo sapiens_hsa04978	0.82585739
50	Metabolic pathways_Homo sapiens_hsa01100	0.81783588
51	Oocyte meiosis_Homo sapiens_hsa04114	0.80716171
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.80316233
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79157766
54	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.77818024
55	Spliceosome_Homo sapiens_hsa03040	0.75928173
56	Renin secretion_Homo sapiens_hsa04924	0.75230903
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.73880129
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.70409189
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68567010
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68547861
61	Purine metabolism_Homo sapiens_hsa00230	0.66561587
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64140503
63	p53 signaling pathway_Homo sapiens_hsa04115	0.63717509
64	ABC transporters_Homo sapiens_hsa02010	0.62679950
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.61408102
66	Peroxisome_Homo sapiens_hsa04146	0.60339263
67	Base excision repair_Homo sapiens_hsa03410	0.58815215
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57375786
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57339375
70	Renin-angiotensin system_Homo sapiens_hsa04614	0.53193953
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51955008
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49866411
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48952793
74	Serotonergic synapse_Homo sapiens_hsa04726	0.48881060
75	Thyroid cancer_Homo sapiens_hsa05216	0.48253514
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45982621
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45487070
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45424479
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41485501
80	Parkinsons disease_Homo sapiens_hsa05012	0.40440683
81	Adherens junction_Homo sapiens_hsa04520	0.39095215
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.36813757
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36510821
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33942135
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.30669419
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30486774
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29283201
88	GABAergic synapse_Homo sapiens_hsa04727	0.28824376
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.28677047
90	Huntingtons disease_Homo sapiens_hsa05016	0.27902134
91	Carbon metabolism_Homo sapiens_hsa01200	0.27779412
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26530092
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.26301210
94	Circadian rhythm_Homo sapiens_hsa04710	0.25849565
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25093869
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24555435
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.24551032
98	Folate biosynthesis_Homo sapiens_hsa00790	0.23502700
99	Regulation of autophagy_Homo sapiens_hsa04140	0.23471986
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23416277

MED28P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »