ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptonemal complex organization (GO:0070193)	6.79901455
2	male meiosis I (GO:0007141)	6.51718213
3	male meiosis (GO:0007140)	5.73017707
4	synapsis (GO:0007129)	5.67178829
5	meiosis I (GO:0007127)	4.84541891
6	meiotic chromosome segregation (GO:0045132)	4.80575725
7	protein maturation by protein folding (GO:0022417)	4.60600915
8	chromosome organization involved in meiosis (GO:0070192)	4.53255687
9	gap junction assembly (GO:0016264)	4.53114165
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.52856830
11	proteasome assembly (GO:0043248)	4.52190817
12	negative regulation of inclusion body assembly (GO:0090084)	4.40438061
13	lens fiber cell development (GO:0070307)	4.36842337
14	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.35339148
15	synaptonemal complex assembly (GO:0007130)	4.32481677
16	intraciliary transport (GO:0042073)	4.21486394
17	sphingomyelin metabolic process (GO:0006684)	4.18985533
18	branched-chain amino acid catabolic process (GO:0009083)	4.16815113
19	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.14835215
20	piRNA metabolic process (GO:0034587)	4.11274198
21	cullin deneddylation (GO:0010388)	4.11020298
22	oligosaccharide catabolic process (GO:0009313)	4.10674031
23	positive regulation of mitochondrial fission (GO:0090141)	4.08814880
24	positive regulation of gastrulation (GO:2000543)	4.00465149
25	C4-dicarboxylate transport (GO:0015740)	3.99417127
26	pseudouridine synthesis (GO:0001522)	3.93297314
27	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.92788235
28	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.89596562
29	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.89087193
30	fatty acid elongation (GO:0030497)	3.68191787
31	COPII vesicle coating (GO:0048208)	3.67677564
32	regulation of sulfur metabolic process (GO:0042762)	3.65147739
33	ventricular septum development (GO:0003281)	3.65071785
34	DNA synthesis involved in DNA repair (GO:0000731)	3.60570389
35	phasic smooth muscle contraction (GO:0014821)	3.59658034
36	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.57191391
37	alanine transport (GO:0032328)	3.56392737
38	heme transport (GO:0015886)	3.51289311
39	lung-associated mesenchyme development (GO:0060484)	3.46299816
40	regulation of coenzyme metabolic process (GO:0051196)	3.45839502
41	regulation of cofactor metabolic process (GO:0051193)	3.45839502
42	L-serine transport (GO:0015825)	3.44440037
43	mesonephros development (GO:0001823)	3.43237392
44	regulation of cholesterol esterification (GO:0010872)	3.42891123
45	meiotic cell cycle process (GO:1903046)	3.41981023
46	head development (GO:0060322)	3.40740213
47	Golgi transport vesicle coating (GO:0048200)	3.36115040
48	COPI coating of Golgi vesicle (GO:0048205)	3.36115040
49	histone H2A ubiquitination (GO:0033522)	3.35624430
50	ether lipid metabolic process (GO:0046485)	3.32341162
51	peptidyl-cysteine modification (GO:0018198)	3.29529875
52	protein deneddylation (GO:0000338)	3.28154991
53	branched-chain amino acid metabolic process (GO:0009081)	3.25384664
54	regulation of fibrinolysis (GO:0051917)	3.19590026
55	left/right axis specification (GO:0070986)	3.18815621
56	eyelid development in camera-type eye (GO:0061029)	3.16902179
57	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.12242014
58	artery smooth muscle contraction (GO:0014824)	3.11884873
59	meiotic nuclear division (GO:0007126)	3.10366237
60	cardiac septum development (GO:0003279)	3.08041840
61	negative regulation of protein autophosphorylation (GO:0031953)	3.06454577
62	vitamin biosynthetic process (GO:0009110)	3.04776593
63	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.04520236
64	embryonic hindlimb morphogenesis (GO:0035116)	3.04504697
65	protein refolding (GO:0042026)	3.03664399
66	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.02401856
67	xenobiotic catabolic process (GO:0042178)	2.99020980
68	L-fucose catabolic process (GO:0042355)	2.96748438
69	fucose catabolic process (GO:0019317)	2.96748438
70	L-fucose metabolic process (GO:0042354)	2.96748438
71	serotonin receptor signaling pathway (GO:0007210)	2.89485418
72	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.89126545
73	cGMP-mediated signaling (GO:0019934)	2.88865531
74	protein localization to Golgi apparatus (GO:0034067)	2.88307820
75	reciprocal DNA recombination (GO:0035825)	2.81790767
76	reciprocal meiotic recombination (GO:0007131)	2.81790767
77	lung morphogenesis (GO:0060425)	2.81082245
78	iron coordination entity transport (GO:1901678)	2.80532424
79	lung epithelium development (GO:0060428)	2.76518135
80	lipid particle organization (GO:0034389)	2.76018503
81	respiratory tube development (GO:0030323)	2.75550500
82	atrial cardiac muscle cell action potential (GO:0086014)	2.72139816
83	hindlimb morphogenesis (GO:0035137)	2.71750818
84	heart valve formation (GO:0003188)	2.71015963
85	vitamin A metabolic process (GO:0006776)	2.70557089
86	vascular smooth muscle contraction (GO:0014829)	2.70409142
87	protein K11-linked deubiquitination (GO:0035871)	2.68771464
88	positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)	2.68194604
89	vasoconstriction (GO:0042310)	2.66815015
90	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.66033536
91	resolution of meiotic recombination intermediates (GO:0000712)	2.65601031
92	serine transport (GO:0032329)	2.64662928
93	negative regulation of smooth muscle cell migration (GO:0014912)	2.63733525
94	cartilage morphogenesis (GO:0060536)	2.61481047
95	tonic smooth muscle contraction (GO:0014820)	2.60012399
96	tRNA aminoacylation for protein translation (GO:0006418)	2.59179524
97	cytoplasmic microtubule organization (GO:0031122)	2.55678491
98	acrosome assembly (GO:0001675)	2.55008082
99	cilium or flagellum-dependent cell motility (GO:0001539)	2.54671583
100	photoreceptor cell maintenance (GO:0045494)	2.54469279

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAF15_26573619_Chip-Seq_HEK293_Human	3.50074798
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.48213655
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.28740148
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.13635592
5	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.99047264
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.98014495
7	VDR_22108803_ChIP-Seq_LS180_Human	2.96815081
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.81102037
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.66482838
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.63256901
11	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.62144252
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.60087320
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.49866576
14	GATA1_22025678_ChIP-Seq_K562_Human	2.42089311
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30384618
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28037073
17	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.21909873
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.15215491
19	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.10063926
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02252638
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.95016214
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.79753433
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77355175
24	P300_19829295_ChIP-Seq_ESCs_Human	1.76973803
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73998701
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.72608520
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.66544054
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.66103267
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.66103267
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65755407
31	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.64980273
32	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.63671996
33	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.63319050
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62087722
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.58393580
36	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.56982850
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.54380331
38	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.53974051
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53627664
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53627664
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52031321
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49955100
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48959297
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47095244
45	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.38508878
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.31493490
47	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.31044110
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30277780
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28036431
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.27988311
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.27279327
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27171918
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26739750
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25001078
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24615980
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23888029
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.23804990
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.22256699
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.16581107
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15673423
61	EOMES_21245162_ChIP-Seq_HESCs_Human	1.15248008
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13329941
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12851542
64	STAT3_23295773_ChIP-Seq_U87_Human	1.12699930
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.12449433
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12337109
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12238795
68	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.10584027
69	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10026308
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09368985
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.09368985
72	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09367555
73	GATA4_25053715_ChIP-Seq_YYC3_Human	1.09139105
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08698999
75	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08271587
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07306349
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05358756
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05212853
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04484541
80	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03817688
81	ER_23166858_ChIP-Seq_MCF-7_Human	1.03059521
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02729326
83	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02226750
84	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.01828506
85	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01407044
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00713928
87	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.00136921
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99153058
89	AR_25329375_ChIP-Seq_VCAP_Human	0.98683272
90	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96760993
91	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.96269512
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95706237
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95535341
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95327176
95	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.94870694
96	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93426689
97	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.92269965
98	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.90714362
99	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.90014605
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89765473

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	6.15966732
2	MP0006054_spinal_hemorrhage	5.96530948
3	MP0005423_abnormal_somatic_nervous	5.17046401
4	MP0003195_calcinosis	3.50207261
5	MP0004147_increased_porphyrin_level	3.13273322
6	MP0005645_abnormal_hypothalamus_physiol	3.07750730
7	MP0004019_abnormal_vitamin_homeostasis	2.78531893
8	MP0008260_abnormal_autophagy	2.69791401
9	MP0000569_abnormal_digit_pigmentation	2.59289409
10	MP0004782_abnormal_surfactant_physiolog	2.58727307
11	MP0010030_abnormal_orbit_morphology	2.30324971
12	MP0003011_delayed_dark_adaptation	2.30056335
13	MP0008775_abnormal_heart_ventricle	2.27598081
14	MP0008877_abnormal_DNA_methylation	2.21385116
15	MP0002653_abnormal_ependyma_morphology	1.85620768
16	MP0002254_reproductive_system_inflammat	1.80079499
17	MP0004084_abnormal_cardiac_muscle	1.75104670
18	MP0006276_abnormal_autonomic_nervous	1.67394918
19	MP0001666_abnormal_nutrient_absorption	1.60533995
20	MP0005408_hypopigmentation	1.60367661
21	MP0002638_abnormal_pupillary_reflex	1.59696762
22	MP0002168_other_aberrant_phenotype	1.57376457
23	MP0005165_increased_susceptibility_to	1.57327414
24	MP0004272_abnormal_basement_membrane	1.54041971
25	MP0003045_fibrosis	1.54014517
26	MP0005395_other_phenotype	1.43046668
27	MP0002295_abnormal_pulmonary_circulatio	1.42569651
28	MP0003718_maternal_effect	1.40801138
29	MP0002139_abnormal_hepatobiliary_system	1.39037861
30	MP0001915_intracranial_hemorrhage	1.38607484
31	MP0005085_abnormal_gallbladder_physiolo	1.38587930
32	MP0005636_abnormal_mineral_homeostasis	1.37439519
33	MP0002876_abnormal_thyroid_physiology	1.35047874
34	MP0002210_abnormal_sex_determination	1.34109815
35	MP0003121_genomic_imprinting	1.30850338
36	MP0001286_abnormal_eye_development	1.28232832
37	MP0001986_abnormal_taste_sensitivity	1.26954637
38	MP0001929_abnormal_gametogenesis	1.25697817
39	MP0005379_endocrine/exocrine_gland_phen	1.25405245
40	MP0004484_altered_response_of	1.24518994
41	MP0003938_abnormal_ear_development	1.22795939
42	MP0002751_abnormal_autonomic_nervous	1.22516530
43	MP0002160_abnormal_reproductive_system	1.20030836
44	MP0005365_abnormal_bile_salt	1.19130555
45	MP0001145_abnormal_male_reproductive	1.18318995
46	MP0003252_abnormal_bile_duct	1.17287305
47	MP0002282_abnormal_trachea_morphology	1.16840101
48	MP0003123_paternal_imprinting	1.12737213
49	MP0005330_cardiomyopathy	1.12498426
50	MP0005410_abnormal_fertilization	1.11497878
51	MP0000631_abnormal_neuroendocrine_gland	1.11146961
52	MP0003567_abnormal_fetal_cardiomyocyte	1.09766725
53	MP0003646_muscle_fatigue	1.08079950
54	MP0010234_abnormal_vibrissa_follicle	1.07914764
55	MP0010329_abnormal_lipoprotein_level	1.06668018
56	MP0002233_abnormal_nose_morphology	1.05992715
57	MP0003698_abnormal_male_reproductive	1.05177887
58	MP0008875_abnormal_xenobiotic_pharmacok	1.04347562
59	MP0000653_abnormal_sex_gland	1.04028102
60	MP0003186_abnormal_redox_activity	1.03995244
61	MP0000639_abnormal_adrenal_gland	1.03642616
62	MP0004510_myositis	1.02644744
63	MP0004133_heterotaxia	1.01804052
64	MP0005551_abnormal_eye_electrophysiolog	1.00104035
65	MP0009053_abnormal_anal_canal	0.96906784
66	MP0002177_abnormal_outer_ear	0.95065583
67	MP0002127_abnormal_cardiovascular_syste	0.94548845
68	MP0001293_anophthalmia	0.94063225
69	MP0004215_abnormal_myocardial_fiber	0.93659163
70	MP0001299_abnormal_eye_distance/	0.92053620
71	MP0006292_abnormal_olfactory_placode	0.91987610
72	MP0004134_abnormal_chest_morphology	0.91961901
73	MP0005367_renal/urinary_system_phenotyp	0.90467276
74	MP0000516_abnormal_urinary_system	0.90467276
75	MP0000372_irregular_coat_pigmentation	0.89643197
76	MP0004036_abnormal_muscle_relaxation	0.88727865
77	MP0005646_abnormal_pituitary_gland	0.87805440
78	MP0002938_white_spotting	0.87300443
79	MP0010368_abnormal_lymphatic_system	0.86180784
80	MP0001764_abnormal_homeostasis	0.85346179
81	MP0002163_abnormal_gland_morphology	0.82175235
82	MP0003937_abnormal_limbs/digits/tail_de	0.80797631
83	MP0003122_maternal_imprinting	0.79699752
84	MP0010352_gastrointestinal_tract_polyps	0.78726182
85	MP0003890_abnormal_embryonic-extraembry	0.78610033
86	MP0003950_abnormal_plasma_membrane	0.76815129
87	MP0005332_abnormal_amino_acid	0.76693227
88	MP0003137_abnormal_impulse_conducting	0.74367550
89	MP0005253_abnormal_eye_physiology	0.73543659
90	MP0000003_abnormal_adipose_tissue	0.71461221
91	MP0005394_taste/olfaction_phenotype	0.70444712
92	MP0005499_abnormal_olfactory_system	0.70444712
93	MP0002837_dystrophic_cardiac_calcinosis	0.69737052
94	MP0005389_reproductive_system_phenotype	0.68458907
95	MP0005195_abnormal_posterior_eye	0.68256630
96	MP0008058_abnormal_DNA_repair	0.67731121
97	MP0005084_abnormal_gallbladder_morpholo	0.64114943
98	MP0005220_abnormal_exocrine_pancreas	0.64013705
99	MP0001756_abnormal_urination	0.63761435
100	MP0005023_abnormal_wound_healing	0.63367545

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short tibia (HP:0005736)	5.14652825
2	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.89385038
3	Popliteal pterygium (HP:0009756)	3.93266796
4	Abnormality of midbrain morphology (HP:0002418)	3.74096478
5	Molar tooth sign on MRI (HP:0002419)	3.74096478
6	Adactyly (HP:0009776)	3.51439467
7	Cone-rod dystrophy (HP:0000548)	3.44515256
8	Myocardial infarction (HP:0001658)	3.43916304
9	Spontaneous abortion (HP:0005268)	3.36004740
10	Central scotoma (HP:0000603)	3.35226264
11	Prolonged partial thromboplastin time (HP:0003645)	3.24469143
12	Hyperactive renin-angiotensin system (HP:0000841)	3.17733064
13	Vascular calcification (HP:0004934)	3.02329101
14	Fibular aplasia (HP:0002990)	2.97451689
15	Abnormal drinking behavior (HP:0030082)	2.96369374
16	Polydipsia (HP:0001959)	2.96369374
17	Bifid tongue (HP:0010297)	2.94599733
18	Azoospermia (HP:0000027)	2.91334490
19	Chronic hepatic failure (HP:0100626)	2.90663624
20	Nephronophthisis (HP:0000090)	2.80210937
21	Abnormal protein glycosylation (HP:0012346)	2.77632360
22	Abnormal glycosylation (HP:0012345)	2.77632360
23	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.77632360
24	Abnormal protein N-linked glycosylation (HP:0012347)	2.77632360
25	Abnormal auditory evoked potentials (HP:0006958)	2.75276093
26	Genital tract atresia (HP:0001827)	2.69623666
27	Polyuria (HP:0000103)	2.69076603
28	Vaginal atresia (HP:0000148)	2.66921873
29	Cardiovascular calcification (HP:0011915)	2.60997344
30	Athetosis (HP:0002305)	2.60958603
31	Medial flaring of the eyebrow (HP:0010747)	2.57493889
32	Type I transferrin isoform profile (HP:0003642)	2.56527470
33	Hypobetalipoproteinemia (HP:0003563)	2.54751025
34	Nephrogenic diabetes insipidus (HP:0009806)	2.54569552
35	Asplenia (HP:0001746)	2.48984264
36	Hyperaldosteronism (HP:0000859)	2.41797640
37	Severe visual impairment (HP:0001141)	2.40785130
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.39592726
39	Abnormality of renal excretion (HP:0011036)	2.38460942
40	Congenital primary aphakia (HP:0007707)	2.38236722
41	Abnormal urine output (HP:0012590)	2.35264777
42	Wide intermamillary distance (HP:0006610)	2.33584755
43	Hyponatremia (HP:0002902)	2.33317149
44	Abnormality of the renal medulla (HP:0100957)	2.33087086
45	Hypolipoproteinemia (HP:0010981)	2.31583951
46	Abnormal spermatogenesis (HP:0008669)	2.30396468
47	Pancreatic fibrosis (HP:0100732)	2.30054944
48	Abnormality of macular pigmentation (HP:0008002)	2.30046074
49	Renal salt wasting (HP:0000127)	2.27630049
50	Occipital encephalocele (HP:0002085)	2.26340530
51	Hypoplastic pelvis (HP:0008839)	2.24970742
52	Anophthalmia (HP:0000528)	2.21263216
53	Gait imbalance (HP:0002141)	2.20389822
54	Facial cleft (HP:0002006)	2.18278020
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18078636
56	Male pseudohermaphroditism (HP:0000037)	2.14177248
57	Hepatocellular necrosis (HP:0001404)	2.13584813
58	Tubular atrophy (HP:0000092)	2.12494096
59	Congenital hepatic fibrosis (HP:0002612)	2.12211024
60	True hermaphroditism (HP:0010459)	2.09810538
61	Abnormality of the renal cortex (HP:0011035)	2.09140753
62	Abnormal platelet function (HP:0011869)	2.08238857
63	Impaired platelet aggregation (HP:0003540)	2.08238857
64	Pancreatic cysts (HP:0001737)	2.07587538
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.07198997
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.07198997
67	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.05140403
68	Short humerus (HP:0005792)	2.04368649
69	Joint hemorrhage (HP:0005261)	2.03904619
70	Mesomelia (HP:0003027)	1.96117337
71	Zonular cataract (HP:0010920)	1.95887061
72	Hypoalphalipoproteinemia (HP:0003233)	1.94678641
73	Abnormality of renal resorption (HP:0011038)	1.93828108
74	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.89393128
75	Keratoconus (HP:0000563)	1.89362149
76	Increased corneal curvature (HP:0100692)	1.89362149
77	Renal tubular acidosis (HP:0001947)	1.88600333
78	Abnormality of the pubic bones (HP:0003172)	1.88573512
79	Decreased muscle mass (HP:0003199)	1.88410967
80	Hepatic necrosis (HP:0002605)	1.88293210
81	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.87692663
82	Acanthocytosis (HP:0001927)	1.86284228
83	Abnormal lung lobation (HP:0002101)	1.85643162
84	Aplasia/hypoplasia of the humerus (HP:0006507)	1.85433652
85	Abnormality of DNA repair (HP:0003254)	1.83152298
86	Chronic bronchitis (HP:0004469)	1.82474546
87	Papillary thyroid carcinoma (HP:0002895)	1.78426035
88	Bicornuate uterus (HP:0000813)	1.77646999
89	Febrile seizures (HP:0002373)	1.76565230
90	Synostosis involving the elbow (HP:0003938)	1.74392421
91	Humeroradial synostosis (HP:0003041)	1.74392421
92	Scotoma (HP:0000575)	1.73017942
93	Abnormality of sodium homeostasis (HP:0010931)	1.72798679
94	Abnormality of the astrocytes (HP:0100707)	1.72756560
95	Astrocytoma (HP:0009592)	1.72756560
96	Hip dysplasia (HP:0001385)	1.69263348
97	Multiple enchondromatosis (HP:0005701)	1.67015964
98	Hypoplasia of the pons (HP:0012110)	1.67012131
99	Supernumerary spleens (HP:0009799)	1.66581181
100	Wide nose (HP:0000445)	1.65229507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	7.22894878
2	SIK3	5.61007052
3	NUAK1	2.82873004
4	CDK19	2.72473871
5	PDK2	2.67835888
6	BMPR1B	2.31205638
7	MAP4K2	2.13350714
8	FRK	2.13340624
9	OXSR1	2.05047903
10	MAP3K2	1.93939359
11	EIF2AK3	1.93562250
12	NEK1	1.92786857
13	TTK	1.91066227
14	VRK1	1.88131864
15	ARAF	1.86957158
16	SIK2	1.77148783
17	TRIM28	1.71504419
18	IRAK4	1.68364136
19	ERN1	1.65988453
20	PLK2	1.46036308
21	PTK2B	1.39372080
22	PLK3	1.37309838
23	TNIK	1.35127167
24	FGR	1.29757732
25	TLK1	1.21455803
26	MAPK15	1.20584731
27	SIK1	1.17310545
28	PAK3	1.12874450
29	MAP3K3	1.11358225
30	NLK	1.08037377
31	MARK3	1.01097609
32	TIE1	0.99850003
33	PIK3CA	0.99026258
34	MST4	0.97323018
35	FLT3	0.97227985
36	BMPR2	0.96999695
37	EPHB2	0.95145073
38	ILK	0.91775502
39	FGFR1	0.91402498
40	MAPK13	0.90480966
41	TYRO3	0.88186420
42	MAP3K9	0.86913603
43	BCR	0.84757762
44	NEK9	0.81123526
45	KSR1	0.80342681
46	PDK1	0.79032791
47	MAP3K13	0.78019512
48	SRPK1	0.77527211
49	ERBB3	0.71740672
50	BRSK1	0.71561712
51	DDR2	0.70237049
52	MARK2	0.70117630
53	FER	0.70114070
54	PDPK1	0.69425825
55	LATS1	0.69377906
56	YES1	0.66875044
57	GRK1	0.66696200
58	FGFR2	0.64611141
59	BCKDK	0.63625407
60	VRK2	0.62537811
61	CSNK1G1	0.61898252
62	PIK3CG	0.59225679
63	BRAF	0.56715486
64	INSR	0.54163475
65	OBSCN	0.50530477
66	AURKB	0.50319660
67	CSNK2A1	0.47258565
68	PRKCQ	0.47198450
69	MKNK2	0.46736279
70	PRKCE	0.45977184
71	MOS	0.45602658
72	TGFBR2	0.45258039
73	CSNK1A1L	0.43922950
74	INSRR	0.43248902
75	ACVR1B	0.43120761
76	RAF1	0.41557058
77	ADRBK1	0.40176630
78	ERBB2	0.40149860
79	CSNK1G3	0.40095565
80	CAMK2A	0.39625567
81	PRKACB	0.39480091
82	PRKAA2	0.39295410
83	PHKG1	0.38744356
84	PHKG2	0.38744356
85	CDK9	0.37608915
86	ATM	0.37536682
87	ADRBK2	0.36300113
88	EIF2AK2	0.35825500
89	STK39	0.35740775
90	AKT2	0.35140082
91	GRK5	0.34547961
92	EGFR	0.32125666
93	IRAK1	0.30504166
94	PKN1	0.27135744
95	STK3	0.27102138
96	STK24	0.26956517
97	MET	0.26053740
98	NTRK2	0.25947705
99	CSNK2A2	0.25652129
100	PRKCI	0.24649133

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.35400071
2	Protein export_Homo sapiens_hsa03060	3.17280797
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.13259044
4	Propanoate metabolism_Homo sapiens_hsa00640	2.85627731
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.47684261
6	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.33985961
7	Complement and coagulation cascades_Homo sapiens_hsa04610	2.32180207
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.23831188
9	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.13734208
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.09548944
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.04853088
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97725887
13	Fatty acid elongation_Homo sapiens_hsa00062	1.96776677
14	Caffeine metabolism_Homo sapiens_hsa00232	1.91435081
15	Sulfur relay system_Homo sapiens_hsa04122	1.84632433
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.81812401
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.74664179
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.70780323
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.64590036
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.61002803
21	Sulfur metabolism_Homo sapiens_hsa00920	1.43498636
22	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.42043757
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.39315264
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34120844
25	Proteasome_Homo sapiens_hsa03050	1.28120207
26	Legionellosis_Homo sapiens_hsa05134	1.26578131
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.24059175
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.23222471
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.18629139
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.18484958
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.18365356
32	Peroxisome_Homo sapiens_hsa04146	1.18013299
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.16479679
34	Circadian rhythm_Homo sapiens_hsa04710	1.15689240
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.14435750
36	Butanoate metabolism_Homo sapiens_hsa00650	1.13502108
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11599884
38	Regulation of autophagy_Homo sapiens_hsa04140	1.10851283
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10676705
40	Basal transcription factors_Homo sapiens_hsa03022	1.04949611
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.03475841
42	Retinol metabolism_Homo sapiens_hsa00830	1.02006817
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99110631
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97699568
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97094131
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96111942
47	RNA polymerase_Homo sapiens_hsa03020	0.95753105
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.94256811
49	Parkinsons disease_Homo sapiens_hsa05012	0.94144218
50	Mineral absorption_Homo sapiens_hsa04978	0.93090481
51	Huntingtons disease_Homo sapiens_hsa05016	0.89318166
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88651539
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.86685355
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.86022677
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81583080
56	Fatty acid degradation_Homo sapiens_hsa00071	0.79625176
57	ABC transporters_Homo sapiens_hsa02010	0.78932699
58	Alzheimers disease_Homo sapiens_hsa05010	0.77406147
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75552588
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.75448529
61	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.71268091
62	ECM-receptor interaction_Homo sapiens_hsa04512	0.70160256
63	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.69798554
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69657975
65	p53 signaling pathway_Homo sapiens_hsa04115	0.69642134
66	One carbon pool by folate_Homo sapiens_hsa00670	0.68856467
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68087245
68	Metabolic pathways_Homo sapiens_hsa01100	0.67955946
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65596134
70	African trypanosomiasis_Homo sapiens_hsa05143	0.65291768
71	RNA degradation_Homo sapiens_hsa03018	0.63974929
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63623216
73	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.63604479
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62628793
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62466330
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59031532
77	Protein digestion and absorption_Homo sapiens_hsa04974	0.58728247
78	Taste transduction_Homo sapiens_hsa04742	0.58419075
79	Phototransduction_Homo sapiens_hsa04744	0.55508379
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55049038
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54414965
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53795239
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50661284
84	Lysine degradation_Homo sapiens_hsa00310	0.49839478
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.48394925
86	Purine metabolism_Homo sapiens_hsa00230	0.45958534
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.45568011
88	Mismatch repair_Homo sapiens_hsa03430	0.45097014
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43820642
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43500914
91	RNA transport_Homo sapiens_hsa03013	0.40401313
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40194476
93	Fanconi anemia pathway_Homo sapiens_hsa03460	0.37340170
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.36166588
95	Galactose metabolism_Homo sapiens_hsa00052	0.35402882
96	Homologous recombination_Homo sapiens_hsa03440	0.35043194
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31953868
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.31503383
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.30787495
100	Other glycan degradation_Homo sapiens_hsa00511	0.30741399

MED28P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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