MED28P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.38173682
2neuron fate determination (GO:0048664)5.91921454
3ribosomal small subunit assembly (GO:0000028)5.81856744
4piRNA metabolic process (GO:0034587)5.65901094
5maturation of SSU-rRNA (GO:0030490)5.37048552
6forebrain neuron differentiation (GO:0021879)5.30378777
7neuronal stem cell maintenance (GO:0097150)5.09301988
8regulation of mesenchymal cell apoptotic process (GO:2001053)5.08814534
9otic vesicle formation (GO:0030916)4.87933214
10limb bud formation (GO:0060174)4.82015229
11ribosomal small subunit biogenesis (GO:0042274)4.81433807
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.78680618
13protein polyglutamylation (GO:0018095)4.73714988
14auditory receptor cell differentiation (GO:0042491)4.52767910
15calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.51502389
16positive regulation of male gonad development (GO:2000020)4.45126348
17sequestering of actin monomers (GO:0042989)4.43218738
18negative regulation of oligodendrocyte differentiation (GO:0048715)4.40574324
19synapsis (GO:0007129)4.37811768
20photoreceptor cell development (GO:0042461)4.35233378
21eye photoreceptor cell development (GO:0042462)4.31685482
22positive regulation of respiratory burst (GO:0060267)4.11166658
23negative regulation by host of viral transcription (GO:0043922)4.03078041
24negative regulation of astrocyte differentiation (GO:0048712)3.97988577
25regulation of male gonad development (GO:2000018)3.95274608
26central nervous system myelination (GO:0022010)3.84251937
27axon ensheathment in central nervous system (GO:0032291)3.84251937
28glyoxylate metabolic process (GO:0046487)3.77810423
29apoptotic DNA fragmentation (GO:0006309)3.76463328
30serotonin receptor signaling pathway (GO:0007210)3.73181512
31cerebral cortex radially oriented cell migration (GO:0021799)3.67235244
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56315558
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56315558
34negative regulation of inclusion body assembly (GO:0090084)3.54971679
35phosphorelay signal transduction system (GO:0000160)3.54270358
36nephron tubule morphogenesis (GO:0072078)3.48601013
37nephron epithelium morphogenesis (GO:0072088)3.48601013
38nonmotile primary cilium assembly (GO:0035058)3.47314108
39regulation of cilium movement (GO:0003352)3.44800656
40DNA methylation involved in gamete generation (GO:0043046)3.44559353
41protein neddylation (GO:0045116)3.37649564
42radial glial cell differentiation (GO:0060019)3.31270844
43negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.31165320
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30457387
45regulation of microtubule-based movement (GO:0060632)3.30024609
46pattern specification involved in kidney development (GO:0061004)3.26522762
47ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.25923044
48maternal behavior (GO:0042711)3.25329452
49startle response (GO:0001964)3.22557990
50negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.19258819
51negative regulation of glial cell differentiation (GO:0045686)3.15290904
52mitochondrion morphogenesis (GO:0070584)3.13858724
53protein refolding (GO:0042026)3.08961072
54viral transcription (GO:0019083)3.05498746
55male sex determination (GO:0030238)3.03176705
56parental behavior (GO:0060746)2.99702539
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99629324
58translational termination (GO:0006415)2.99316368
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97728274
60telencephalon development (GO:0021537)2.97073831
61endothelial tube morphogenesis (GO:0061154)2.96689684
62morphogenesis of an endothelium (GO:0003159)2.96689684
63sex determination (GO:0007530)2.93952953
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93950657
65male meiosis (GO:0007140)2.92276528
66regulation of oligodendrocyte differentiation (GO:0048713)2.89638700
67vascular smooth muscle contraction (GO:0014829)2.87540697
68regulation of timing of cell differentiation (GO:0048505)2.87527055
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86779761
70ATP synthesis coupled proton transport (GO:0015986)2.86779761
71regulation of astrocyte differentiation (GO:0048710)2.81860560
72platelet dense granule organization (GO:0060155)2.81850405
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78757985
74neural tube formation (GO:0001841)2.78227526
75renal tubule morphogenesis (GO:0061333)2.75222109
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70844389
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.70844389
78NADH dehydrogenase complex assembly (GO:0010257)2.70844389
79response to pheromone (GO:0019236)2.69754051
80positive regulation of Notch signaling pathway (GO:0045747)2.68503753
81DNA deamination (GO:0045006)2.68306757
82regulation of inclusion body assembly (GO:0090083)2.67987743
83somite development (GO:0061053)2.67484676
84negative regulation of execution phase of apoptosis (GO:1900118)2.62244928
85regulation of meiosis I (GO:0060631)2.59295907
86retinal ganglion cell axon guidance (GO:0031290)2.59059876
87regulation of development, heterochronic (GO:0040034)2.58907825
88pyrimidine nucleobase catabolic process (GO:0006208)2.58054325
89astrocyte differentiation (GO:0048708)2.58030206
90kidney morphogenesis (GO:0060993)2.54694418
91male meiosis I (GO:0007141)2.51391823
92neuronal action potential propagation (GO:0019227)2.51228269
93gene silencing by RNA (GO:0031047)2.50480143
94regulation of neuron migration (GO:2001222)2.47731129
95adaptation of signaling pathway (GO:0023058)2.47503374
96phagocytosis, recognition (GO:0006910)2.45082969
97protein complex biogenesis (GO:0070271)2.44953054
98translational elongation (GO:0006414)2.44405395
99chaperone-mediated protein transport (GO:0072321)2.44174675
100retinal rod cell development (GO:0046548)11.5978147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.24162120
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.46951226
3TAF15_26573619_Chip-Seq_HEK293_Human3.13413310
4IRF1_19129219_ChIP-ChIP_H3396_Human2.96472052
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.94454998
6ZNF274_21170338_ChIP-Seq_K562_Hela2.37888757
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34572101
8TP53_16413492_ChIP-PET_HCT116_Human2.28580962
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22281436
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.22082039
11RNF2_27304074_Chip-Seq_NSC_Mouse2.15250665
12MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human2.10030431
13GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.96117726
14SOX2_16153702_ChIP-ChIP_HESCs_Human1.94724020
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93836245
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90654709
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.84718656
18P300_19829295_ChIP-Seq_ESCs_Human1.80871632
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80773249
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76347665
21FUS_26573619_Chip-Seq_HEK293_Human1.76112263
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75874500
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73495019
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73495019
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73495019
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72091225
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70909260
28MYC_18940864_ChIP-ChIP_HL60_Human1.70417444
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67924999
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63270117
31IGF1R_20145208_ChIP-Seq_DFB_Human1.62137535
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.61059151
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59990715
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.59624004
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56413967
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56413967
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52502389
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.51455536
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50214323
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49786771
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.46852377
42BCAT_22108803_ChIP-Seq_LS180_Human1.46559451
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.45464833
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44285822
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43788861
46TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43153675
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36821544
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36356364
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36084903
50ER_23166858_ChIP-Seq_MCF-7_Human1.34436016
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33511581
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32381420
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28861606
54GBX2_23144817_ChIP-Seq_PC3_Human1.28277501
55EWS_26573619_Chip-Seq_HEK293_Human1.24099577
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21698528
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21082392
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20493681
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20235949
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19290628
61PHF8_20622853_ChIP-Seq_HELA_Human1.17566275
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.17377420
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.17228536
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17228536
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15040052
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.13298129
67MYC_19829295_ChIP-Seq_ESCs_Human1.12333695
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11828412
69TBL1_22424771_ChIP-Seq_293T_Human1.11793611
70TP53_22573176_ChIP-Seq_HFKS_Human1.11708238
71SMAD4_21799915_ChIP-Seq_A2780_Human1.11051594
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10113619
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09452550
74HOXB7_26014856_ChIP-Seq_BT474_Human1.09301925
75NFYB_21822215_ChIP-Seq_K562_Human1.09176919
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08432090
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07933000
78ETV1_20927104_ChIP-Seq_GIST48_Human1.06866524
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06615565
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06598929
81REST_21632747_ChIP-Seq_MESCs_Mouse1.04318594
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04263901
83AR_25329375_ChIP-Seq_VCAP_Human1.03974886
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02797875
85NFYA_21822215_ChIP-Seq_K562_Human1.02606826
86TAF2_19829295_ChIP-Seq_ESCs_Human1.02551557
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02274239
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01927611
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.01704862
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01515366
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.00865665
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.00782577
93CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00764396
94GATA3_21867929_ChIP-Seq_TH1_Mouse1.00570925
95SOX2_19829295_ChIP-Seq_ESCs_Human0.99974658
96NANOG_19829295_ChIP-Seq_ESCs_Human0.99974658
97TP53_18474530_ChIP-ChIP_U2OS_Human0.98359236
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98111314
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97471004
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97370541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.29307928
2MP0008877_abnormal_DNA_methylation3.94602037
3MP0000569_abnormal_digit_pigmentation3.79397607
4MP0001485_abnormal_pinna_reflex3.65921498
5MP0003880_abnormal_central_pattern3.46655147
6MP0004885_abnormal_endolymph3.36656224
7MP0000566_synostosis3.28767754
8MP0005174_abnormal_tail_pigmentation3.07936594
9MP0004742_abnormal_vestibular_system2.96382568
10MP0006292_abnormal_olfactory_placode2.77631365
11MP0009384_cardiac_valve_regurgitation2.47503494
12MP0008789_abnormal_olfactory_epithelium2.31589987
13MP0005551_abnormal_eye_electrophysiolog2.25678141
14MP0002938_white_spotting2.24038981
15MP0002282_abnormal_trachea_morphology2.23063106
16MP0001529_abnormal_vocalization2.21517706
17MP0000049_abnormal_middle_ear2.17815958
18MP0001764_abnormal_homeostasis2.07200252
19MP0002736_abnormal_nociception_after2.02785364
20MP0005377_hearing/vestibular/ear_phenot1.98150933
21MP0003878_abnormal_ear_physiology1.98150933
22MP0006072_abnormal_retinal_apoptosis1.85255376
23MP0010030_abnormal_orbit_morphology1.77292896
24MP0005394_taste/olfaction_phenotype1.62501090
25MP0005499_abnormal_olfactory_system1.62501090
26MP0008260_abnormal_autophagy1.59705234
27MP0005253_abnormal_eye_physiology1.43196572
28MP0002095_abnormal_skin_pigmentation1.40542053
29MP0003938_abnormal_ear_development1.35288233
30MP0005360_urolithiasis1.32303713
31MP0000026_abnormal_inner_ear1.31207178
32MP0000778_abnormal_nervous_system1.30800197
33MP0005195_abnormal_posterior_eye1.30739407
34MP0005423_abnormal_somatic_nervous1.28926209
35MP0001968_abnormal_touch/_nociception1.28198869
36MP0008007_abnormal_cellular_replicative1.26517674
37MP0003119_abnormal_digestive_system1.24206832
38MP0002822_catalepsy1.21860102
39MP0008058_abnormal_DNA_repair1.20827392
40MP0002234_abnormal_pharynx_morphology1.19579492
41MP0003136_yellow_coat_color1.16596224
42MP0002735_abnormal_chemical_nociception1.16540845
43MP0002653_abnormal_ependyma_morphology1.14773393
44MP0000383_abnormal_hair_follicle1.11877183
45MP0000631_abnormal_neuroendocrine_gland1.11472698
46MP0002557_abnormal_social/conspecific_i1.10876420
47MP0009250_abnormal_appendicular_skeleto1.10409510
48MP0002638_abnormal_pupillary_reflex1.09150178
49MP0003787_abnormal_imprinting1.08913725
50MP0001963_abnormal_hearing_physiology1.08155331
51MP0001299_abnormal_eye_distance/1.05764770
52MP0003121_genomic_imprinting1.03157133
53MP0009745_abnormal_behavioral_response1.01117948
54MP0001984_abnormal_olfaction1.00979705
55MP0003755_abnormal_palate_morphology0.98851438
56MP0000516_abnormal_urinary_system0.95099954
57MP0005367_renal/urinary_system_phenotyp0.95099954
58MP0004859_abnormal_synaptic_plasticity0.94522190
59MP0002233_abnormal_nose_morphology0.92461674
60MP0005391_vision/eye_phenotype0.92451886
61MP0002751_abnormal_autonomic_nervous0.88024542
62MP0002752_abnormal_somatic_nervous0.87835544
63MP0001286_abnormal_eye_development0.86636646
64MP0002734_abnormal_mechanical_nocicepti0.86279488
65MP0001293_anophthalmia0.85425338
66MP0006276_abnormal_autonomic_nervous0.83678469
67MP0003937_abnormal_limbs/digits/tail_de0.82822176
68MP0001929_abnormal_gametogenesis0.81785855
69MP0004147_increased_porphyrin_level0.81764332
70MP0002249_abnormal_larynx_morphology0.80757758
71MP0002067_abnormal_sensory_capabilities0.79791099
72MP0001970_abnormal_pain_threshold0.79695774
73MP0000428_abnormal_craniofacial_morphol0.77178886
74MP0001486_abnormal_startle_reflex0.75925897
75MP0004142_abnormal_muscle_tone0.75511653
76MP0002098_abnormal_vibrissa_morphology0.73528919
77MP0002210_abnormal_sex_determination0.72321977
78MP0001188_hyperpigmentation0.69946010
79MP0002733_abnormal_thermal_nociception0.68861553
80MP0002572_abnormal_emotion/affect_behav0.66820572
81MP0001919_abnormal_reproductive_system0.63487256
82MP0003890_abnormal_embryonic-extraembry0.62704857
83MP0004145_abnormal_muscle_electrophysio0.62328416
84MP0000955_abnormal_spinal_cord0.61204645
85MP0010094_abnormal_chromosome_stability0.60387123
86MP0002272_abnormal_nervous_system0.59430165
87MP0002063_abnormal_learning/memory/cond0.59346858
88MP0002109_abnormal_limb_morphology0.58996703
89MP0003698_abnormal_male_reproductive0.58382994
90MP0008775_abnormal_heart_ventricle0.57982730
91MP0009053_abnormal_anal_canal0.57146027
92MP0008872_abnormal_physiological_respon0.56993367
93MP0001905_abnormal_dopamine_level0.56604232
94MP0002116_abnormal_craniofacial_bone0.55786373
95MP0003283_abnormal_digestive_organ0.55593947
96MP0001502_abnormal_circadian_rhythm0.55508060
97MP0001324_abnormal_eye_pigmentation0.54972133
98MP0000467_abnormal_esophagus_morphology0.54678477
99MP0000749_muscle_degeneration0.54198854
100MP0002882_abnormal_neuron_morphology0.53366780

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)7.48932074
211 pairs of ribs (HP:0000878)7.20089416
3Diaphragmatic weakness (HP:0009113)5.02427244
4Morphological abnormality of the inner ear (HP:0011390)4.96515319
5Abolished electroretinogram (ERG) (HP:0000550)4.85456285
6Reticulocytopenia (HP:0001896)4.71180602
7Missing ribs (HP:0000921)4.24315260
8Colon cancer (HP:0003003)4.03691860
9Partial duplication of thumb phalanx (HP:0009944)3.94350104
10True hermaphroditism (HP:0010459)3.86036379
11Morphological abnormality of the middle ear (HP:0008609)3.80757665
12Abnormality of midbrain morphology (HP:0002418)3.76656633
13Molar tooth sign on MRI (HP:0002419)3.76656633
14Abnormality of DNA repair (HP:0003254)3.54449600
15Partial duplication of the phalanx of hand (HP:0009999)3.44131339
16Difficulty running (HP:0009046)3.25087754
17Volvulus (HP:0002580)3.18962662
18Vertebral hypoplasia (HP:0008417)3.18783006
19Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.18783006
20Chronic hepatic failure (HP:0100626)3.07660957
21Congenital, generalized hypertrichosis (HP:0004540)3.03933396
22Progressive sensorineural hearing impairment (HP:0000408)2.75613728
23Abnormality of the middle phalanges of the toes (HP:0010183)2.72179465
24Abnormality of the metopic suture (HP:0005556)2.71245805
25Pancreatic fibrosis (HP:0100732)2.71167168
26Septo-optic dysplasia (HP:0100842)2.68391011
27Aplasia/Hypoplasia of the sternum (HP:0006714)2.65199845
28Increased hepatocellular lipid droplets (HP:0006565)2.59214147
29Carpal bone hypoplasia (HP:0001498)2.55769547
30Hypoplastic iliac wings (HP:0002866)2.52815586
31Duplication of thumb phalanx (HP:0009942)2.46529768
32Nephronophthisis (HP:0000090)2.44806272
33Acute necrotizing encephalopathy (HP:0006965)2.44061864
34Prominent metopic ridge (HP:0005487)2.43714145
35Concave nail (HP:0001598)2.43166027
36Trigonocephaly (HP:0000243)2.42258361
37Absent septum pellucidum (HP:0001331)2.40818859
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40432730
39Hip contracture (HP:0003273)2.33851254
40Absent thumb (HP:0009777)2.32138508
41Acute encephalopathy (HP:0006846)2.31861936
42Partial agenesis of the corpus callosum (HP:0001338)2.23355870
43Pancreatic cysts (HP:0001737)2.21205982
44Abnormal sex determination (HP:0012244)2.21076968
45Sex reversal (HP:0012245)2.21076968
46Focal motor seizures (HP:0011153)2.19345089
47Midline defect of the nose (HP:0004122)2.18960303
48Severe muscular hypotonia (HP:0006829)2.17472934
49Anencephaly (HP:0002323)2.17146518
50Stenosis of the external auditory canal (HP:0000402)2.16715298
51Disproportionate short-trunk short stature (HP:0003521)2.12243440
52Mitochondrial inheritance (HP:0001427)2.11756511
53Tubular atrophy (HP:0000092)2.11271651
54Renal cortical cysts (HP:0000803)2.07652237
55Hip dysplasia (HP:0001385)2.07486983
56Lipid accumulation in hepatocytes (HP:0006561)2.02596039
57Hypoplastic ilia (HP:0000946)2.01464608
58Small hand (HP:0200055)2.01108713
59Increased CSF lactate (HP:0002490)2.00167522
60Optic nerve hypoplasia (HP:0000609)1.99360253
61Abnormality of the renal medulla (HP:0100957)1.98917019
623-Methylglutaconic aciduria (HP:0003535)1.98405234
63Postaxial foot polydactyly (HP:0001830)1.94317464
64Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.93941196
65Abnormality of the renal cortex (HP:0011035)1.93328332
66Abnormality of the labia minora (HP:0012880)1.92010251
67Limb hypertonia (HP:0002509)1.91958472
68Abnormal mitochondria in muscle tissue (HP:0008316)1.91884232
69Bronchomalacia (HP:0002780)1.90991235
70Sclerocornea (HP:0000647)1.90430005
71Progressive macrocephaly (HP:0004481)1.87990020
72Abnormality of the septum pellucidum (HP:0007375)1.87589907
73Sleep apnea (HP:0010535)1.83953633
74Abnormality of the parietal bone (HP:0002696)1.83269338
75Male pseudohermaphroditism (HP:0000037)1.80898574
76Narrow forehead (HP:0000341)1.78115408
77Abnormal respiratory motile cilium physiology (HP:0012261)1.77191660
78Exertional dyspnea (HP:0002875)1.76098572
79Epiphyseal dysplasia (HP:0002656)1.75823400
80Preaxial hand polydactyly (HP:0001177)1.75503329
81Hyperglycinuria (HP:0003108)1.74842611
82Abnormal vertebral ossification (HP:0100569)1.73902239
83Congenital hepatic fibrosis (HP:0002612)1.72398570
84Median cleft lip (HP:0000161)1.72081193
85Thrombocytosis (HP:0001894)1.71454941
86Rib fusion (HP:0000902)1.70845045
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.69590660
88Dyskinesia (HP:0100660)1.67503322
89Postaxial hand polydactyly (HP:0001162)1.67277177
90Abnormal ciliary motility (HP:0012262)1.66063610
91Macrocytic anemia (HP:0001972)1.64797688
92Abnormality of cochlea (HP:0000375)1.63320324
932-3 toe syndactyly (HP:0004691)1.62953891
94Optic nerve coloboma (HP:0000588)1.61816285
95Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.61761480
96Retinal dysplasia (HP:0007973)1.61363194
97Oligodactyly (HP:0012165)1.61258221
98Metaphyseal irregularity (HP:0003025)1.60132004
99Hypoplasia of the odontoid process (HP:0003311)1.59828519
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.59347086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK15.39615482
2TSSK65.01081144
3CASK4.52770057
4INSRR4.33794548
5PNCK4.19679645
6BMPR1B3.66893353
7WEE12.97303210
8MAPKAPK32.49024130
9MKNK22.41599499
10MUSK2.39285908
11MAPK152.20862401
12STK392.06582529
13TNIK2.02243185
14OXSR11.97532792
15TIE11.67031218
16WNK41.57633201
17TXK1.38182724
18TGFBR11.31924806
19EPHA41.31315869
20NTRK31.25399143
21CAMK1G1.22578332
22DAPK21.21018970
23MAPKAPK51.18069113
24GRK11.11672730
25FGFR21.11547875
26MKNK11.06786386
27VRK11.05016612
28CAMK1D1.04688387
29PTK2B0.99616600
30DYRK30.99008684
31MELK0.98881842
32CCNB10.96096150
33CDK190.93067681
34LATS20.92570229
35CLK10.91634998
36CSNK1G20.90554108
37CDK80.85114922
38CAMK10.81817970
39NME10.81481674
40FRK0.80565894
41ADRBK20.80100503
42PAK20.77854634
43MAP3K110.77813784
44UHMK10.77352550
45STK30.76510066
46CDK30.73737026
47ACVR1B0.73124198
48TESK10.72148704
49BRSK10.71077415
50STK240.62487364
51EIF2AK30.62357173
52STK110.61028046
53PRKCG0.60873005
54EPHB20.59864567
55ZAK0.57076933
56ROCK10.56474273
57WNK30.55930970
58KIT0.54649957
59NUAK10.53939031
60PLK30.52380264
61PLK10.51969159
62FGFR10.51230650
63CSNK1G30.50288285
64PBK0.48447953
65NEK20.48376686
66CAMKK20.48302893
67ADRBK10.47834963
68SCYL20.47729657
69CHEK20.47042152
70MAP4K20.46272774
71BCR0.42474384
72PAK30.41712315
73AURKB0.41322206
74AKT30.40756142
75CAMKK10.40198797
76VRK20.39750296
77PRKCE0.38836077
78MINK10.38773322
79MARK10.38606985
80BRAF0.36317796
81PLK40.35934985
82STK40.34874971
83TRIM280.32677591
84CSNK1G10.32195347
85MAP3K40.31663816
86MAP3K120.31182564
87ATR0.30527865
88PIK3CA0.30019697
89PAK60.27891092
90PRKCZ0.27439951
91TEC0.25424544
92KSR10.24965833
93PRKACA0.23980510
94DAPK10.23542226
95BRSK20.23435177
96CHUK0.22620061
97PRKCQ0.22440499
98IGF1R0.21952507
99TLK10.21520118
100CSNK1A1L0.20867547

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.72499984
2Ribosome_Homo sapiens_hsa030103.89873521
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.23136799
4Oxidative phosphorylation_Homo sapiens_hsa001903.17977007
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89963320
6Parkinsons disease_Homo sapiens_hsa050122.78955384
7Phototransduction_Homo sapiens_hsa047442.77033613
8Huntingtons disease_Homo sapiens_hsa050162.62234792
9RNA polymerase_Homo sapiens_hsa030202.61242385
10Cardiac muscle contraction_Homo sapiens_hsa042602.17977389
11Alzheimers disease_Homo sapiens_hsa050102.02935003
12RNA degradation_Homo sapiens_hsa030181.99969333
13Prion diseases_Homo sapiens_hsa050201.85801822
14Butanoate metabolism_Homo sapiens_hsa006501.82971982
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74144625
16Taste transduction_Homo sapiens_hsa047421.71831990
17Ether lipid metabolism_Homo sapiens_hsa005651.57735623
18Nicotine addiction_Homo sapiens_hsa050331.55528928
19Steroid biosynthesis_Homo sapiens_hsa001001.45738371
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39027312
21Homologous recombination_Homo sapiens_hsa034401.32637114
22Linoleic acid metabolism_Homo sapiens_hsa005911.31108636
23Basal cell carcinoma_Homo sapiens_hsa052171.28395632
24Base excision repair_Homo sapiens_hsa034101.28171155
25Basal transcription factors_Homo sapiens_hsa030221.26165659
26Vitamin digestion and absorption_Homo sapiens_hsa049771.23264396
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21772119
28Protein export_Homo sapiens_hsa030601.19062170
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17078743
30Notch signaling pathway_Homo sapiens_hsa043301.16590938
31Peroxisome_Homo sapiens_hsa041461.15296332
32Spliceosome_Homo sapiens_hsa030401.14674572
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12662805
34p53 signaling pathway_Homo sapiens_hsa041151.12274498
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02758269
36Dorso-ventral axis formation_Homo sapiens_hsa043201.01512321
37Pyrimidine metabolism_Homo sapiens_hsa002401.00220131
38Axon guidance_Homo sapiens_hsa043600.99146864
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97155764
40Serotonergic synapse_Homo sapiens_hsa047260.96254105
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95075469
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94589553
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93583086
44Nucleotide excision repair_Homo sapiens_hsa034200.92853371
45Primary immunodeficiency_Homo sapiens_hsa053400.92630895
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.90808796
47Nitrogen metabolism_Homo sapiens_hsa009100.88134579
48Regulation of autophagy_Homo sapiens_hsa041400.86592160
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78311750
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.78027384
51GABAergic synapse_Homo sapiens_hsa047270.77840368
52Retinol metabolism_Homo sapiens_hsa008300.76093274
53cAMP signaling pathway_Homo sapiens_hsa040240.75074028
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.74129029
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73918450
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73849192
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73679252
58Proteasome_Homo sapiens_hsa030500.71157398
59Hippo signaling pathway_Homo sapiens_hsa043900.70636117
60ABC transporters_Homo sapiens_hsa020100.67942002
61DNA replication_Homo sapiens_hsa030300.66931425
62Olfactory transduction_Homo sapiens_hsa047400.66424368
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65904950
64TGF-beta signaling pathway_Homo sapiens_hsa043500.65554001
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65419666
66Mineral absorption_Homo sapiens_hsa049780.64794499
67Legionellosis_Homo sapiens_hsa051340.64728168
68Fatty acid elongation_Homo sapiens_hsa000620.63509023
69Cell cycle_Homo sapiens_hsa041100.63079986
70Wnt signaling pathway_Homo sapiens_hsa043100.58304330
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55428146
72Cocaine addiction_Homo sapiens_hsa050300.54231997
73Hedgehog signaling pathway_Homo sapiens_hsa043400.51761197
74Fat digestion and absorption_Homo sapiens_hsa049750.50907788
75Arginine and proline metabolism_Homo sapiens_hsa003300.50473369
76Tryptophan metabolism_Homo sapiens_hsa003800.48830413
77Morphine addiction_Homo sapiens_hsa050320.47974784
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47943457
79Metabolic pathways_Homo sapiens_hsa011000.46878747
80Melanoma_Homo sapiens_hsa052180.44866968
81Antigen processing and presentation_Homo sapiens_hsa046120.43539105
82Prostate cancer_Homo sapiens_hsa052150.43286208
83Glutamatergic synapse_Homo sapiens_hsa047240.42385971
84Arachidonic acid metabolism_Homo sapiens_hsa005900.42108439
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41612122
86Purine metabolism_Homo sapiens_hsa002300.39561597
87Fatty acid metabolism_Homo sapiens_hsa012120.39541874
88MAPK signaling pathway_Homo sapiens_hsa040100.38323007
89Fanconi anemia pathway_Homo sapiens_hsa034600.35546779
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35256613
91Alcoholism_Homo sapiens_hsa050340.32569013
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32422785
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32374258
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32359722
95Amphetamine addiction_Homo sapiens_hsa050310.30941181
96Circadian entrainment_Homo sapiens_hsa047130.30549844
97Estrogen signaling pathway_Homo sapiens_hsa049150.29021946
98Ras signaling pathway_Homo sapiens_hsa040140.28282903
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27222623
100Oxytocin signaling pathway_Homo sapiens_hsa049210.23350685

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »