MED29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.33906503
2maturation of SSU-rRNA (GO:0030490)5.20936464
3termination of RNA polymerase III transcription (GO:0006386)5.19979606
4transcription elongation from RNA polymerase III promoter (GO:0006385)5.19979606
5proteasome assembly (GO:0043248)5.04792355
6ATP synthesis coupled proton transport (GO:0015986)4.95853502
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.95853502
8DNA deamination (GO:0045006)4.95408026
97-methylguanosine mRNA capping (GO:0006370)4.91500048
107-methylguanosine RNA capping (GO:0009452)4.85050103
11RNA capping (GO:0036260)4.85050103
12ribosomal small subunit biogenesis (GO:0042274)4.82938924
13synaptic vesicle maturation (GO:0016188)4.71855321
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.68090989
15ribosomal small subunit assembly (GO:0000028)4.56606450
16ribosomal large subunit biogenesis (GO:0042273)4.52191828
17negative regulation of DNA-templated transcription, elongation (GO:0032785)4.46082786
18rRNA modification (GO:0000154)4.45300701
19peptidyl-arginine omega-N-methylation (GO:0035247)4.40787503
20myelin maintenance (GO:0043217)4.36525915
21viral transcription (GO:0019083)4.33630317
22synaptic vesicle exocytosis (GO:0016079)4.32353003
23transcription elongation from RNA polymerase I promoter (GO:0006362)4.28587855
24purine nucleobase biosynthetic process (GO:0009113)4.27312622
25translational termination (GO:0006415)4.24945574
26ribonucleoprotein complex biogenesis (GO:0022613)4.22977946
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.22955281
28protein neddylation (GO:0045116)4.22714889
29DNA replication checkpoint (GO:0000076)4.21759863
30termination of RNA polymerase I transcription (GO:0006363)4.19669025
31spliceosomal snRNP assembly (GO:0000387)4.17116981
32glutamate secretion (GO:0014047)4.16986448
33chaperone-mediated protein transport (GO:0072321)4.14836548
34transcription from RNA polymerase I promoter (GO:0006360)4.14594033
35respiratory electron transport chain (GO:0022904)4.01995972
36nucleobase biosynthetic process (GO:0046112)4.00388007
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98843615
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.96816926
39NADH dehydrogenase complex assembly (GO:0010257)3.96816926
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96816926
41positive regulation of vesicle fusion (GO:0031340)3.94755191
42electron transport chain (GO:0022900)3.93177327
43spliceosomal complex assembly (GO:0000245)3.91857832
44ribosome biogenesis (GO:0042254)3.91831066
45GTP biosynthetic process (GO:0006183)3.89354657
46cellular component biogenesis (GO:0044085)3.89271228
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.88132091
48rRNA processing (GO:0006364)3.86978589
49regulation of mitochondrial translation (GO:0070129)3.86409947
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.84730089
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83532184
52cotranslational protein targeting to membrane (GO:0006613)3.82845387
53translational elongation (GO:0006414)3.79465853
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77611470
55pseudouridine synthesis (GO:0001522)3.77229567
56negative regulation of ligase activity (GO:0051352)3.77181049
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77181049
58protein targeting to ER (GO:0045047)3.77174377
59guanosine-containing compound biosynthetic process (GO:1901070)3.77111815
60protein insertion into membrane (GO:0051205)3.74146780
61mitotic metaphase plate congression (GO:0007080)3.74001195
62rRNA metabolic process (GO:0016072)3.73499449
63translational initiation (GO:0006413)3.72242259
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72098897
65transcription-coupled nucleotide-excision repair (GO:0006283)3.71776055
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.71429006
67transcription elongation from RNA polymerase II promoter (GO:0006368)3.69957993
68establishment of protein localization to mitochondrion (GO:0072655)3.69529866
69translation (GO:0006412)3.69159435
70peptidyl-histidine modification (GO:0018202)3.68911754
71protein complex biogenesis (GO:0070271)3.68681898
72protein targeting to mitochondrion (GO:0006626)3.67209101
73regulation of cellular amino acid metabolic process (GO:0006521)3.63792986
74ribosome assembly (GO:0042255)3.60915643
75protein localization to endoplasmic reticulum (GO:0070972)3.59682644
76transcription initiation from RNA polymerase I promoter (GO:0006361)3.58097343
77UTP biosynthetic process (GO:0006228)3.57303860
78establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56359944
79DNA-templated transcription, elongation (GO:0006354)3.56313299
80chromatin remodeling at centromere (GO:0031055)3.53807084
81mitochondrial respiratory chain complex assembly (GO:0033108)3.49982307
82CENP-A containing nucleosome assembly (GO:0034080)3.49205376
83regulation of vesicle fusion (GO:0031338)3.49143998
84rRNA methylation (GO:0031167)3.48584579
85regulation of autophagic vacuole assembly (GO:2000785)3.46796526
86positive regulation of viral transcription (GO:0050434)3.45614410
87cellular potassium ion homeostasis (GO:0030007)3.45444818
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44074206
89membrane tubulation (GO:0097320)3.43762146
90L-methionine salvage (GO:0071267)3.43076407
91L-methionine biosynthetic process (GO:0071265)3.43076407
92amino acid salvage (GO:0043102)3.43076407
93cellular protein complex disassembly (GO:0043624)3.41773099
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41622444
95peptidyl-arginine N-methylation (GO:0035246)3.39659013
96peptidyl-arginine methylation (GO:0018216)3.39659013
97viral life cycle (GO:0019058)3.37937949
98protein localization to mitochondrion (GO:0070585)3.36913183
99negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36439111
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35687116
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35470960
102regulation of protein targeting to membrane (GO:0090313)3.35049463
103maturation of 5.8S rRNA (GO:0000460)3.30989945
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30439499
105neurotransmitter secretion (GO:0007269)3.27907222
106positive regulation of ligase activity (GO:0051351)3.27594763
107detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.24630918
108detection of temperature stimulus involved in sensory perception (GO:0050961)3.24630918
109histone arginine methylation (GO:0034969)3.24246559
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22165152
111spliceosomal tri-snRNP complex assembly (GO:0000244)3.21854247
112base-excision repair, AP site formation (GO:0006285)3.21742609
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18588908
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18588908
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18588908
116signal transduction involved in DNA damage checkpoint (GO:0072422)3.18185796
117signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18185796
118formation of translation preinitiation complex (GO:0001731)3.18139977
119kinetochore assembly (GO:0051382)3.17780026
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15490156
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15490156
122positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.14233472
123signal transduction involved in cell cycle checkpoint (GO:0072395)3.12990936
124regulation of cellular respiration (GO:0043457)3.10541313
125response to misfolded protein (GO:0051788)3.02760765
126regulation of glucose import in response to insulin stimulus (GO:2001273)2.99251603
127iron-sulfur cluster assembly (GO:0016226)2.98701575
128metallo-sulfur cluster assembly (GO:0031163)2.98701575
129regulation of synaptic vesicle exocytosis (GO:2000300)2.98280816
130positive regulation of fatty acid beta-oxidation (GO:0032000)2.98206164
131negative regulation of amino acid transport (GO:0051956)2.96241896
132regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94071886
133positive regulation of protein targeting to membrane (GO:0090314)2.93174854
134nuclear envelope reassembly (GO:0031468)2.90850530
135mitotic nuclear envelope reassembly (GO:0007084)2.90850530
136negative regulation of glycogen biosynthetic process (GO:0045719)2.90213638
137regulation of vacuole organization (GO:0044088)2.89248884
138sodium ion export (GO:0071436)2.87364795
139positive regulation of synapse maturation (GO:0090129)2.82369979
140regulation of voltage-gated calcium channel activity (GO:1901385)2.80544671
141regulation of cholesterol biosynthetic process (GO:0045540)2.80356112
142regulation of fatty acid beta-oxidation (GO:0031998)2.77625627
143virion assembly (GO:0019068)2.77534698
144establishment of mitochondrion localization (GO:0051654)2.76372644
145positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75590288
146ubiquinone biosynthetic process (GO:0006744)2.74818433
147amino acid import (GO:0043090)2.74198721
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72726250
149locomotory exploration behavior (GO:0035641)2.72624849
150negative regulation of glycogen metabolic process (GO:0070874)2.71228501
151protein retention in ER lumen (GO:0006621)2.71079690
152mitochondrial calcium ion transport (GO:0006851)2.70563608
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68780553
154positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64813403
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64309186
156response to gravity (GO:0009629)2.63462501
157regulation of oxidative stress-induced neuron death (GO:1903203)2.63246167
158negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.62752586
159postsynaptic membrane organization (GO:0001941)2.62303647
160regulation of neurotransmitter levels (GO:0001505)2.59945058
161cullin deneddylation (GO:0010388)2.59454693
162COPI coating of Golgi vesicle (GO:0048205)2.57974461
163Golgi transport vesicle coating (GO:0048200)2.57974461
164regulation of synaptic vesicle transport (GO:1902803)2.55959392
165histone H2B ubiquitination (GO:0033523)2.54533599
166regulation of neuronal synaptic plasticity (GO:0048168)2.53591768
167protein maturation by protein folding (GO:0022417)2.53288995
168neuronal ion channel clustering (GO:0045161)2.52655015
169mammary gland epithelial cell differentiation (GO:0060644)2.52621269
170negative regulation of microtubule polymerization (GO:0031115)2.52115677
171energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.51859487
172ATP hydrolysis coupled proton transport (GO:0015991)2.51859487
173protein deneddylation (GO:0000338)2.50370600
174protein localization to endosome (GO:0036010)2.49712560
175axon ensheathment in central nervous system (GO:0032291)2.46644337
176central nervous system myelination (GO:0022010)2.46644337
177regulation of synaptic plasticity (GO:0048167)2.46582913
178regulation of defense response to virus by virus (GO:0050690)2.46489288
179adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.46276942
180viral protein processing (GO:0019082)2.45580744
181negative regulation of organic acid transport (GO:0032891)2.45360729
182cerebellar Purkinje cell layer development (GO:0021680)2.41701356
183behavioral response to cocaine (GO:0048148)2.41695405
184sleep (GO:0030431)2.40826639
185fatty acid elongation (GO:0030497)2.39926653
186positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38632436
187neurotransmitter transport (GO:0006836)2.37923773
188positive regulation of DNA-templated transcription, elongation (GO:0032786)2.35589704
189positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.35256964
190maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35018483
191regulation of catecholamine metabolic process (GO:0042069)2.34726186
192regulation of dopamine metabolic process (GO:0042053)2.34726186
193regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.33724634
194protein localization to synapse (GO:0035418)2.33471547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.00162753
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94214249
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.40668249
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.26117868
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.24712039
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.11389005
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.86451294
8E2F7_22180533_ChIP-Seq_HELA_Human3.76788748
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.61344005
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.52411796
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46889670
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12930346
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07799445
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05872949
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94625140
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94548709
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93322726
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87867194
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.83422301
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82190029
21* VDR_23849224_ChIP-Seq_CD4+_Human2.62675427
22* XRN2_22483619_ChIP-Seq_HELA_Human2.44370895
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42291418
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42277793
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.35583521
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.34707335
27DCP1A_22483619_ChIP-Seq_HELA_Human2.34402456
28LXR_22292898_ChIP-Seq_THP-1_Human2.34268492
29* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33762556
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28278390
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27628086
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25633642
33FOXP3_21729870_ChIP-Seq_TREG_Human2.20224782
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20078704
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.15090843
36TET1_21451524_ChIP-Seq_MESCs_Mouse2.14943999
37GABP_19822575_ChIP-Seq_HepG2_Human2.11932576
38* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04282918
39NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03612198
40* TTF2_22483619_ChIP-Seq_HELA_Human2.03307831
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01653693
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.95781639
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92979987
44ELK1_19687146_ChIP-ChIP_HELA_Human1.91275246
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85267803
46P68_20966046_ChIP-Seq_HELA_Human1.83784537
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82725141
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78678468
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.73719321
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73168686
51VDR_21846776_ChIP-Seq_THP-1_Human1.72862385
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70015804
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68986007
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68095906
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67071160
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.65858252
57RACK7_27058665_Chip-Seq_MCF-7_Human1.62991578
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61396858
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60749010
60* ELK1_22589737_ChIP-Seq_MCF10A_Human1.59697341
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.58228777
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51262741
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51192653
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49729382
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49286448
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48131193
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48117826
68BCL6_27268052_Chip-Seq_Bcells_Human1.47659819
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.45526190
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43825021
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43214891
72BCOR_27268052_Chip-Seq_Bcells_Human1.42496129
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40273214
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.37053022
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34442528
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34048237
77CTCF_20526341_ChIP-Seq_ESCs_Human1.33605237
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32412034
79CIITA_25753668_ChIP-Seq_RAJI_Human1.31688608
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.31008672
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30799034
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30373926
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29636013
84FOXP1_21924763_ChIP-Seq_HESCs_Human1.29059515
85MYC_18940864_ChIP-ChIP_HL60_Human1.27122598
86SA1_27219007_Chip-Seq_Bcells_Human1.26769285
87SMC4_20622854_ChIP-Seq_HELA_Human1.26259176
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26028820
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24782209
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.24515937
91CTCF_27219007_Chip-Seq_Bcells_Human1.24473564
92CREB1_26743006_Chip-Seq_LNCaP_Human1.23949425
93KDM2B_26808549_Chip-Seq_DND41_Human1.23635881
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21862122
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21373008
96AR_21909140_ChIP-Seq_LNCAP_Human1.21325982
97TP53_22127205_ChIP-Seq_IMR90_Human1.20881250
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19877311
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19730760
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19132017
101KDM5A_27292631_Chip-Seq_BREAST_Human1.18972174
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18823532
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.18666767
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.18342439
105* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17918898
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15573542
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14780436
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.14460279
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13280522
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.12977445
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12730394
112JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09184187
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08880437
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08781807
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08551408
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08060055
117MAF_26560356_Chip-Seq_TH2_Human1.07959635
118KDM2B_26808549_Chip-Seq_K562_Human1.07599461
119* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07356207
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06456618
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06348480
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.06105493
123PHF8_20622854_ChIP-Seq_HELA_Human1.05376161
124E2F1_20622854_ChIP-Seq_HELA_Human1.04895207
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.04872285
126PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04517299
127KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04483285
128* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04111880
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04037063
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.03244313
131TET1_21490601_ChIP-Seq_MESCs_Mouse1.02439394
132SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02087701
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01913547
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99969251
135MYC_22102868_ChIP-Seq_BL_Human0.99822443
136IRF1_19129219_ChIP-ChIP_H3396_Human0.98875497
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98665925
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97676624
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97638659
140E2F1_21310950_ChIP-Seq_MCF-7_Human0.96904626
141TP53_20018659_ChIP-ChIP_R1E_Mouse0.96815666
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93597440
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90905749
144SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90091275
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.89104180
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86862763
147CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85684314
148NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84451376
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83424682
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82200309
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.81981091
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81971249
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79242115
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78633248
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77963137
156OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76926445
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75408270
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75352519
159* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75089062
160HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74310038
161KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.73148581
162CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73033404
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72997671
164* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71533256
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69286618
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69235526
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66888295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.09956873
2MP0003693_abnormal_embryo_hatching4.93014997
3MP0004859_abnormal_synaptic_plasticity4.61011577
4MP0003941_abnormal_skin_development3.57790333
5MP0000566_synostosis3.43800636
6MP0004957_abnormal_blastocyst_morpholog3.40607521
7MP0003718_maternal_effect3.34459048
8MP0003111_abnormal_nucleus_morphology3.00751596
9MP0003329_amyloid_beta_deposits2.99260183
10MP0005423_abnormal_somatic_nervous2.79628524
11MP0003635_abnormal_synaptic_transmissio2.77945186
12MP0001188_hyperpigmentation2.72802445
13MP0008058_abnormal_DNA_repair2.69437099
14MP0001968_abnormal_touch/_nociception2.67893849
15MP0004270_analgesia2.60992552
16MP0003077_abnormal_cell_cycle2.60272389
17MP0010094_abnormal_chromosome_stability2.58993688
18MP0005623_abnormal_meninges_morphology2.57566865
19MP0002064_seizures2.54369150
20MP0003123_paternal_imprinting2.52509935
21MP0008932_abnormal_embryonic_tissue2.49198130
22MP0003786_premature_aging2.40761336
23MP0002063_abnormal_learning/memory/cond2.39548532
24MP0008057_abnormal_DNA_replication2.38061190
25MP0002736_abnormal_nociception_after2.35840544
26MP0006292_abnormal_olfactory_placode2.32904322
27MP0009745_abnormal_behavioral_response2.31063357
28MP0008877_abnormal_DNA_methylation2.26082112
29MP0002163_abnormal_gland_morphology2.19340103
30MP0003136_yellow_coat_color2.17989567
31MP0002572_abnormal_emotion/affect_behav2.16188316
32MP0001502_abnormal_circadian_rhythm2.14101011
33MP0008007_abnormal_cellular_replicative2.12016933
34MP0001529_abnormal_vocalization2.08597791
35MP0003879_abnormal_hair_cell2.06417918
36MP0006036_abnormal_mitochondrial_physio1.98036622
37MP0002132_abnormal_respiratory_system1.97716334
38MP0002272_abnormal_nervous_system1.95591555
39MP0002734_abnormal_mechanical_nocicepti1.94610519
40MP0002249_abnormal_larynx_morphology1.93891972
41MP0002733_abnormal_thermal_nociception1.89887496
42MP0004185_abnormal_adipocyte_glucose1.86949317
43MP0003315_abnormal_perineum_morphology1.86514048
44MP0002735_abnormal_chemical_nociception1.81882988
45MP0002638_abnormal_pupillary_reflex1.79634395
46MP0001905_abnormal_dopamine_level1.79149961
47MP0009046_muscle_twitch1.75418383
48MP0001970_abnormal_pain_threshold1.73574410
49MP0003690_abnormal_glial_cell1.68976909
50MP0003075_altered_response_to1.66735839
51MP0009840_abnormal_foam_cell1.62208219
52MP0005409_darkened_coat_color1.61460642
53MP0001501_abnormal_sleep_pattern1.60198322
54MP0001486_abnormal_startle_reflex1.60187758
55MP0004130_abnormal_muscle_cell1.54880699
56MP0005058_abnormal_lysosome_morphology1.53125088
57MP0008995_early_reproductive_senescence1.52410491
58MP0005451_abnormal_body_composition1.49939131
59MP0008569_lethality_at_weaning1.47882588
60MP0000604_amyloidosis1.46132920
61MP0000681_abnormal_thyroid_gland1.44514195
62MP0003186_abnormal_redox_activity1.43900543
63MP0006035_abnormal_mitochondrial_morpho1.43682836
64MP0002102_abnormal_ear_morphology1.42544999
65MP0002210_abnormal_sex_determination1.37939967
66MP0006276_abnormal_autonomic_nervous1.36736129
67MP0001661_extended_life_span1.35603358
68MP0001929_abnormal_gametogenesis1.35418020
69MP0005379_endocrine/exocrine_gland_phen1.33427103
70MP0001346_abnormal_lacrimal_gland1.33139375
71MP0002277_abnormal_respiratory_mucosa1.32088943
72MP0003880_abnormal_central_pattern1.30389354
73MP0001984_abnormal_olfaction1.28601568
74MP0000920_abnormal_myelination1.28382715
75MP0000015_abnormal_ear_pigmentation1.26852318
76MP0004858_abnormal_nervous_system1.26728453
77MP0003172_abnormal_lysosome_physiology1.25950927
78MP0005410_abnormal_fertilization1.25050750
79MP0003634_abnormal_glial_cell1.24312453
80MP0002557_abnormal_social/conspecific_i1.24075003
81MP0001730_embryonic_growth_arrest1.22235949
82MP0000955_abnormal_spinal_cord1.20995144
83MP0006072_abnormal_retinal_apoptosis1.20792278
84MP0002876_abnormal_thyroid_physiology1.20191606
85MP0000678_abnormal_parathyroid_gland1.19020122
86MP0003121_genomic_imprinting1.18251251
87MP0001145_abnormal_male_reproductive1.17399381
88MP0004142_abnormal_muscle_tone1.17203370
89MP0003283_abnormal_digestive_organ1.16048165
90MP0002066_abnormal_motor_capabilities/c1.15833928
91MP0000750_abnormal_muscle_regeneration1.15077101
92MP0000537_abnormal_urethra_morphology1.14993768
93MP0009697_abnormal_copulation1.14534196
94MP0000653_abnormal_sex_gland1.13330495
95MP0004811_abnormal_neuron_physiology1.12777946
96MP0002938_white_spotting1.12692896
97MP0009333_abnormal_splenocyte_physiolog1.10868925
98MP0000026_abnormal_inner_ear1.09441207
99MP0003191_abnormal_cellular_cholesterol1.09403100
100MP0003633_abnormal_nervous_system1.07432876
101MP0005174_abnormal_tail_pigmentation1.07167627
102MP0003698_abnormal_male_reproductive1.05834380
103MP0001348_abnormal_lacrimal_gland1.05824290
104MP0002882_abnormal_neuron_morphology1.04351782
105MP0008260_abnormal_autophagy1.03452263
106MP0003938_abnormal_ear_development1.02017586
107MP0005646_abnormal_pituitary_gland1.00931812
108MP0004742_abnormal_vestibular_system1.00361216
109MP0003806_abnormal_nucleotide_metabolis0.98978103
110MP0005645_abnormal_hypothalamus_physiol0.98848416
111MP0001963_abnormal_hearing_physiology0.98646166
112MP0002160_abnormal_reproductive_system0.97957353
113MP0003122_maternal_imprinting0.97863188
114MP0000372_irregular_coat_pigmentation0.97020629
115MP0003119_abnormal_digestive_system0.96169826
116MP0002909_abnormal_adrenal_gland0.95685052
117MP0008872_abnormal_physiological_respon0.95432439
118MP0004885_abnormal_endolymph0.94166984
119MP0008874_decreased_physiological_sensi0.93911334
120MP0002067_abnormal_sensory_capabilities0.93392638
121MP0009278_abnormal_bone_marrow0.93173717
122MP0005408_hypopigmentation0.93111511
123MP0002229_neurodegeneration0.93023501
124MP0005389_reproductive_system_phenotype0.92184334
125MP0004381_abnormal_hair_follicle0.91182901
126MP0001485_abnormal_pinna_reflex0.91135668
127MP0000350_abnormal_cell_proliferation0.90265987
128MP0001440_abnormal_grooming_behavior0.88852996
129MP0001672_abnormal_embryogenesis/_devel0.87462231
130MP0005380_embryogenesis_phenotype0.87462231
131MP0002152_abnormal_brain_morphology0.86005416
132MP0000049_abnormal_middle_ear0.84708134
133MP0000778_abnormal_nervous_system0.84669314
134MP0005584_abnormal_enzyme/coenzyme_acti0.84553495
135MP0005166_decreased_susceptibility_to0.84056234
136MP0001727_abnormal_embryo_implantation0.83460182
137MP0002751_abnormal_autonomic_nervous0.82702193
138MP0004133_heterotaxia0.82562813
139MP0001697_abnormal_embryo_size0.82193284
140MP0005395_other_phenotype0.80892472
141MP0004145_abnormal_muscle_electrophysio0.79337876
142MP0003646_muscle_fatigue0.79058482
143MP0000313_abnormal_cell_death0.79041692
144MP0002080_prenatal_lethality0.78464383
145MP0002822_catalepsy0.78145552
146MP0008961_abnormal_basal_metabolism0.77989181
147MP0000358_abnormal_cell_content/0.77969406
148MP0002653_abnormal_ependyma_morphology0.76876616
149MP0003436_decreased_susceptibility_to0.75768259
150MP0001764_abnormal_homeostasis0.75046275
151MP0001873_stomach_inflammation0.74993218
152MP0003631_nervous_system_phenotype0.74698850
153MP0001119_abnormal_female_reproductive0.72664692
154MP0002177_abnormal_outer_ear0.72350282
155MP0002184_abnormal_innervation0.72045890
156MP0002085_abnormal_embryonic_tissue0.71484200
157MP0003787_abnormal_imprinting0.71071403
158MP0003221_abnormal_cardiomyocyte_apopto0.70910124
159MP0002127_abnormal_cardiovascular_syste0.70214370
160MP0001919_abnormal_reproductive_system0.69943213
161MP0003942_abnormal_urinary_system0.68518111
162MP0005636_abnormal_mineral_homeostasis0.67843939
163MP0002161_abnormal_fertility/fecundity0.67370251
164MP0000747_muscle_weakness0.67293823
165MP0003937_abnormal_limbs/digits/tail_de0.67006713
166MP0010386_abnormal_urinary_bladder0.66305632
167MP0001756_abnormal_urination0.64127364
168MP0008789_abnormal_olfactory_epithelium0.64062392
169MP0002069_abnormal_eating/drinking_beha0.63865543
170MP0005386_behavior/neurological_phenoty0.63818645
171MP0004924_abnormal_behavior0.63818645
172MP0003279_aneurysm0.63805257
173MP0004019_abnormal_vitamin_homeostasis0.62622049
174MP0000613_abnormal_salivary_gland0.62127630
175MP0003984_embryonic_growth_retardation0.60833940
176MP0002095_abnormal_skin_pigmentation0.60166688
177MP0005666_abnormal_adipose_tissue0.59862323
178MP0005535_abnormal_body_temperature0.59737804
179MP0001986_abnormal_taste_sensitivity0.59661083
180MP0002169_no_abnormal_phenotype0.58567732
181MP0001542_abnormal_bone_strength0.58561884
182MP0002873_normal_phenotype0.58130318

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.49066149
2Mitochondrial inheritance (HP:0001427)4.95148134
3Myokymia (HP:0002411)4.91843543
4Abnormal mitochondria in muscle tissue (HP:0008316)4.80016914
5Acute encephalopathy (HP:0006846)4.45642390
6Progressive macrocephaly (HP:0004481)4.43594364
7Increased CSF lactate (HP:0002490)4.34551412
8Hepatocellular necrosis (HP:0001404)4.33848379
9Abnormality of cells of the erythroid lineage (HP:0012130)4.02758816
10Increased hepatocellular lipid droplets (HP:0006565)4.01811419
11Large for gestational age (HP:0001520)3.92649778
12Hepatic necrosis (HP:0002605)3.88172496
13Birth length less than 3rd percentile (HP:0003561)3.87559015
14Cerebral hypomyelination (HP:0006808)3.78765798
15Aplasia/hypoplasia of the uterus (HP:0008684)3.77734276
16Ankle clonus (HP:0011448)3.72462612
17Breast hypoplasia (HP:0003187)3.68767921
18Abnormal number of erythroid precursors (HP:0012131)3.68304465
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.66424154
20Reticulocytopenia (HP:0001896)3.62373338
21Renal Fanconi syndrome (HP:0001994)3.61567527
223-Methylglutaconic aciduria (HP:0003535)3.54745825
23Lipid accumulation in hepatocytes (HP:0006561)3.46948556
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.43089102
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39781179
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39781179
27Macrocytic anemia (HP:0001972)3.33795963
28Increased serum lactate (HP:0002151)3.30457718
29Late onset (HP:0003584)3.27833069
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.24888164
31Carpal bone hypoplasia (HP:0001498)3.21071997
32Supranuclear gaze palsy (HP:0000605)3.20952237
33Diplopia (HP:0000651)3.17641439
34Abnormality of binocular vision (HP:0011514)3.17641439
35Neonatal hypoglycemia (HP:0001998)3.14789231
36Cerebral edema (HP:0002181)3.05305906
37Hypoplasia of the uterus (HP:0000013)3.02746256
38Mutism (HP:0002300)2.99806316
39Exertional dyspnea (HP:0002875)2.97259470
40Respiratory failure (HP:0002878)2.94950118
41Exercise intolerance (HP:0003546)2.92224147
42Rough bone trabeculation (HP:0100670)2.88035893
43Lactic acidosis (HP:0003128)2.87461443
44Respiratory difficulties (HP:0002880)2.85833199
45Obstructive sleep apnea (HP:0002870)2.85591894
46Broad distal phalanx of finger (HP:0009836)2.83909768
47Secondary amenorrhea (HP:0000869)2.76736968
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75024806
49Vertebral compression fractures (HP:0002953)2.74208555
50Focal motor seizures (HP:0011153)2.70872663
51Increased intramyocellular lipid droplets (HP:0012240)2.69431717
52Oral leukoplakia (HP:0002745)2.64339488
53CNS demyelination (HP:0007305)2.62488133
54Optic disc pallor (HP:0000543)2.60896109
55Neuronal loss in central nervous system (HP:0002529)2.60698477
56Patellar aplasia (HP:0006443)2.60122024
57Pallor (HP:0000980)2.59702670
58Microvesicular hepatic steatosis (HP:0001414)2.59444914
59Aplasia/Hypoplasia of the patella (HP:0006498)2.59094161
60Abnormality of glycolysis (HP:0004366)2.53317502
61Increased serum pyruvate (HP:0003542)2.53317502
62Horseshoe kidney (HP:0000085)2.53004549
63Visual hallucinations (HP:0002367)2.52751116
64Progressive microcephaly (HP:0000253)2.48999299
65Akinesia (HP:0002304)2.46794632
66Leukodystrophy (HP:0002415)2.46477563
67Neurofibrillary tangles (HP:0002185)2.45477211
68Abnormal eating behavior (HP:0100738)2.44470972
69Peripheral hypomyelination (HP:0007182)2.44175956
70Spastic tetraparesis (HP:0001285)2.44124449
71CNS hypomyelination (HP:0003429)2.43425645
72Tetraplegia (HP:0002445)2.43133527
73Hyperglycinemia (HP:0002154)2.42955324
74Testicular atrophy (HP:0000029)2.40159732
75Abnormality of renal resorption (HP:0011038)2.39777420
76Delusions (HP:0000746)2.39247241
77Truncal ataxia (HP:0002078)2.39225426
78Impulsivity (HP:0100710)2.37881045
79Aplastic anemia (HP:0001915)2.37667788
80Emotional lability (HP:0000712)2.36253655
81Diminished motivation (HP:0000745)2.33538359
82Growth hormone excess (HP:0000845)2.33043213
83Pancreatic fibrosis (HP:0100732)2.28265421
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.28142680
85Apathy (HP:0000741)2.27196385
86Pancreatic cysts (HP:0001737)2.26754029
87Abnormal trabecular bone morphology (HP:0100671)2.25523967
88Epileptic encephalopathy (HP:0200134)2.24234500
89Absent radius (HP:0003974)2.23743330
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22941573
91Abnormality of the labia minora (HP:0012880)2.22660821
92Opisthotonus (HP:0002179)2.21490465
93Slow saccadic eye movements (HP:0000514)2.21370810
94Microretrognathia (HP:0000308)2.21048407
95Spastic paraparesis (HP:0002313)2.20910619
96Loss of speech (HP:0002371)2.19539905
97Unsteady gait (HP:0002317)2.19328919
98Congenital ichthyosiform erythroderma (HP:0007431)2.18200776
99Lethargy (HP:0001254)2.16100331
100Paraparesis (HP:0002385)2.13436990
101Ragged-red muscle fibers (HP:0003200)2.12513355
102Cleft eyelid (HP:0000625)2.12141492
103Absent forearm bone (HP:0003953)2.11447316
104Aplasia involving forearm bones (HP:0009822)2.11447316
105Hypokinesia (HP:0002375)2.10634746
106Cerebral inclusion bodies (HP:0100314)2.10064395
107Popliteal pterygium (HP:0009756)2.09804543
108Abnormality of the ileum (HP:0001549)2.08821596
109Action tremor (HP:0002345)2.08205358
110Insulin resistance (HP:0000855)2.07857929
111Increased muscle lipid content (HP:0009058)2.07330052
112Abnormality of the distal phalanges of the toes (HP:0010182)2.04386419
113Meckel diverticulum (HP:0002245)2.02586152
114Spastic gait (HP:0002064)2.02235473
115Concave nail (HP:0001598)2.00434430
116Abnormality of liposaccharide metabolism (HP:0010968)2.00253147
117Abnormality of glycosphingolipid metabolism (HP:0004343)2.00253147
118Abnormality of glycolipid metabolism (HP:0010969)2.00253147
119Hyperacusis (HP:0010780)1.99876376
120Absent thumb (HP:0009777)1.96223541
121Sleep apnea (HP:0010535)1.95405989
122Stenosis of the external auditory canal (HP:0000402)1.94988347
123Acanthosis nigricans (HP:0000956)1.94958387
124Dysmetria (HP:0001310)1.94746006
125Split foot (HP:0001839)1.93821601
126Hyperphosphaturia (HP:0003109)1.93516656
127Supernumerary spleens (HP:0009799)1.93037047
128Trismus (HP:0000211)1.91800319
129Polyphagia (HP:0002591)1.90741247
130Amniotic constriction ring (HP:0009775)1.89033728
131Abnormality of placental membranes (HP:0011409)1.89033728
132Abnormality of the preputium (HP:0100587)1.88008086
133Premature graying of hair (HP:0002216)1.87939390
134Rigidity (HP:0002063)1.87763766
135Parakeratosis (HP:0001036)1.87483442
136Pancytopenia (HP:0001876)1.86912612
137Focal dystonia (HP:0004373)1.85382087
138Craniofacial dystonia (HP:0012179)1.85107308
139Premature ovarian failure (HP:0008209)1.84807066
140Progressive muscle weakness (HP:0003323)1.84662895
141Type I transferrin isoform profile (HP:0003642)1.84101058
142Abnormal spermatogenesis (HP:0008669)1.83698837
143Triphalangeal thumb (HP:0001199)1.81302705
144Abnormality of urine glucose concentration (HP:0011016)1.81251041
145Glycosuria (HP:0003076)1.81251041
146Irregular epiphyses (HP:0010582)1.79683258
147Ureteral duplication (HP:0000073)1.77910395
148Hyperglycinuria (HP:0003108)1.77723077
149Anomalous pulmonary venous return (HP:0010772)1.77423924
150Poor suck (HP:0002033)1.76800904
151Torticollis (HP:0000473)1.75831935
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75333578
153Athetosis (HP:0002305)1.75081549
154Axonal loss (HP:0003447)1.74339024
155Abnormality of magnesium homeostasis (HP:0004921)1.73791956
156Annular pancreas (HP:0001734)1.73105762
157Anxiety (HP:0000739)1.72407857
158Stridor (HP:0010307)1.72059079
159Depression (HP:0000716)1.71898187
160Epileptiform EEG discharges (HP:0011182)1.71440896
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71182922
162Hypoplasia of the radius (HP:0002984)1.70750767
163Megaloblastic anemia (HP:0001889)1.69341077
164Type I diabetes mellitus (HP:0100651)1.68498746
165Choreoathetosis (HP:0001266)1.68452800
166Dementia (HP:0000726)1.67776269
167Synostosis involving the elbow (HP:0003938)1.67364926
168Humeroradial synostosis (HP:0003041)1.67364926
169Hyperparathyroidism (HP:0000843)1.67100005
170Back pain (HP:0003418)1.66906727
171Limb dystonia (HP:0002451)1.66557124
172Duplicated collecting system (HP:0000081)1.66284969
173Insomnia (HP:0100785)1.66007378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB37.66509503
2BUB14.47119151
3SRPK14.23512985
4WEE13.56970134
5STK163.23447223
6NME23.21373655
7EIF2AK13.12613412
8CAMKK12.83178458
9TLK12.77827970
10TESK12.55577494
11PLK42.51053127
12BRSK22.43332332
13VRK22.23884476
14MKNK22.19945108
15PAK62.08744565
16NME12.01376176
17VRK12.00957769
18PRKD31.98366813
19EIF2AK31.93459071
20AKT31.88424130
21BRAF1.82570755
22SIK21.78769401
23ILK1.78600800
24ZAK1.68903533
25MKNK11.68406356
26LRRK21.63347263
27PLK11.61033732
28CAMKK21.54046155
29NTRK11.53616212
30PLK31.47708592
31EPHA41.46910662
32TTK1.45704345
33TSSK61.44924692
34ERN11.44465728
35IRAK31.43449420
36PRPF4B1.43445967
37ARAF1.43200033
38PBK1.41427221
39EPHB11.41136978
40ACVR1B1.40402746
41CCNB11.39787951
42STK38L1.38057370
43BRSK11.38025111
44TESK21.37576852
45DYRK21.32359591
46CDC71.28883054
47CASK1.22173484
48TXK1.21860332
49MST41.21278926
50PHKG21.20521705
51PHKG11.20521705
52PNCK1.19652252
53MARK11.19522758
54AURKB1.17973085
55CDK81.17163407
56AURKA1.15807554
57MAP3K131.15055239
58LMTK21.14133306
59TAOK21.13021978
60MAP3K31.12466491
61CHEK21.10607507
62SMG11.08948078
63DYRK31.08730991
64PINK11.07518071
65NEK21.04591156
66PIM21.03828719
67SIK10.99922047
68BCR0.99720103
69DAPK10.99568314
70NTRK20.97150834
71CDK90.96834646
72EIF2AK20.95957230
73EPHA20.94375356
74MAPK150.92868331
75LATS20.90312931
76MAP4K20.89566435
77CDK190.89308357
78PRKD20.88421521
79BCKDK0.87872833
80ABL20.86344772
81CSNK1G30.85535352
82DAPK20.84880285
83PRKCI0.82912962
84CDK70.78522575
85LIMK10.77088092
86MUSK0.76715461
87CSNK2A10.76051981
88MARK30.74147533
89STK390.73314836
90CAMK2B0.72464969
91CDK11A0.72404635
92PIK3CG0.70673627
93PDPK10.70008880
94CDK140.69637806
95TBK10.69336315
96PAK10.68992438
97UHMK10.68486796
98CSNK2A20.68358626
99CSNK1G10.67832736
100CDK150.67610230
101DYRK1B0.67239555
102BRD40.67236440
103MAP2K70.67211325
104RPS6KA50.65687346
105IRAK40.65091584
106OBSCN0.64483208
107CDK180.63809725
108ATR0.61887173
109CHEK10.61762022
110STK380.61089018
111MINK10.60229667
112BMPR1B0.59644900
113MYLK0.58823288
114OXSR10.56960741
115SCYL20.56909522
116PAK40.55718990
117MAPKAPK30.55460056
118PDK10.54892045
119PRKCZ0.54504227
120ADRBK20.53594900
121NEK60.51535382
122RPS6KA40.51319947
123CDK30.51203904
124NUAK10.50893599
125CAMK10.50421454
126KDR0.49989349
127EPHA30.49678380
128GRK70.48259823
129FES0.47063663
130MAP3K120.46952915
131WNK30.46906670
132ALK0.46535255
133CDK50.45742759
134MAP3K110.43678126
135PDK30.42782046
136PDK40.42782046
137IRAK10.41033008
138CSNK1G20.40229910
139PTK20.39459296
140PRKCG0.39294473
141CDK20.38296256
142PLK20.38275348
143CAMK2D0.37424468
144PASK0.36085075
145MOS0.35369827
146ATM0.35183470
147NTRK30.35161117
148BLK0.35158123
149ROCK20.34999585
150PKN10.34009767
151STK240.33960382
152TYRO30.33860852
153MARK20.33641884
154MAP2K20.33439595
155CAMK2G0.32888704
156GRK60.32793163
157CSNK1A1L0.32564039
158IRAK20.31812035
159CSNK1E0.31664649
160WNK40.31664066
161MAP4K10.30976811
162CDK10.30752129
163GRK50.30222732
164HIPK20.29825077
165CSNK1A10.29703063
166MAP3K80.29646299
167PRKCD0.29395973
168TAOK10.28643872
169DAPK30.28211288

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.75655074
2Ribosome_Homo sapiens_hsa030104.55039320
3Proteasome_Homo sapiens_hsa030504.20655512
4Oxidative phosphorylation_Homo sapiens_hsa001903.74218504
5Synaptic vesicle cycle_Homo sapiens_hsa047213.42879588
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30134178
7Parkinsons disease_Homo sapiens_hsa050123.27284615
8DNA replication_Homo sapiens_hsa030303.08374658
9Pyrimidine metabolism_Homo sapiens_hsa002402.79472064
10Huntingtons disease_Homo sapiens_hsa050162.75010022
11Mismatch repair_Homo sapiens_hsa034302.70315374
12Spliceosome_Homo sapiens_hsa030402.61273245
13Protein export_Homo sapiens_hsa030602.57962798
14Homologous recombination_Homo sapiens_hsa034402.39450766
15Basal transcription factors_Homo sapiens_hsa030222.36266077
16Vitamin B6 metabolism_Homo sapiens_hsa007502.35635333
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.31285855
18Nucleotide excision repair_Homo sapiens_hsa034202.30687251
19RNA transport_Homo sapiens_hsa030132.23154516
20Alzheimers disease_Homo sapiens_hsa050102.20123201
21Amphetamine addiction_Homo sapiens_hsa050312.12184310
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97239506
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94317375
24Nicotine addiction_Homo sapiens_hsa050331.87833780
25Cocaine addiction_Homo sapiens_hsa050301.82778934
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81641731
27Purine metabolism_Homo sapiens_hsa002301.73365603
28Fanconi anemia pathway_Homo sapiens_hsa034601.71769636
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69713778
30Base excision repair_Homo sapiens_hsa034101.63631281
31Cell cycle_Homo sapiens_hsa041101.55150222
32Sulfur relay system_Homo sapiens_hsa041221.53878138
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52990856
34RNA degradation_Homo sapiens_hsa030181.47961892
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46763517
36Folate biosynthesis_Homo sapiens_hsa007901.41841889
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41566504
38Other glycan degradation_Homo sapiens_hsa005111.39432596
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36919654
40One carbon pool by folate_Homo sapiens_hsa006701.34523872
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31136878
42Dopaminergic synapse_Homo sapiens_hsa047281.29785967
43Cardiac muscle contraction_Homo sapiens_hsa042601.28974329
44GABAergic synapse_Homo sapiens_hsa047271.26746046
45Morphine addiction_Homo sapiens_hsa050321.25941636
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20075235
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16208268
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15117885
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14798665
50Insulin secretion_Homo sapiens_hsa049111.13038343
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.11976989
52Endocytosis_Homo sapiens_hsa041441.11353162
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05234208
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04242227
55Non-homologous end-joining_Homo sapiens_hsa034501.03413080
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.97030719
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94353240
58p53 signaling pathway_Homo sapiens_hsa041150.91609430
59Cholinergic synapse_Homo sapiens_hsa047250.90189112
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89461200
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89410543
62mRNA surveillance pathway_Homo sapiens_hsa030150.88462707
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87856074
64Circadian entrainment_Homo sapiens_hsa047130.86488755
65Gastric acid secretion_Homo sapiens_hsa049710.86359685
66Steroid biosynthesis_Homo sapiens_hsa001000.86319167
67Epstein-Barr virus infection_Homo sapiens_hsa051690.86069835
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.85740102
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84252915
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80641255
71Shigellosis_Homo sapiens_hsa051310.80623155
72Metabolic pathways_Homo sapiens_hsa011000.79980825
73Pentose phosphate pathway_Homo sapiens_hsa000300.76295691
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75751347
75Glutathione metabolism_Homo sapiens_hsa004800.75714332
76Prion diseases_Homo sapiens_hsa050200.74523194
77Long-term potentiation_Homo sapiens_hsa047200.73912436
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72532516
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.71519065
80cAMP signaling pathway_Homo sapiens_hsa040240.71283800
81Collecting duct acid secretion_Homo sapiens_hsa049660.70387805
82Lysosome_Homo sapiens_hsa041420.67891773
83Arachidonic acid metabolism_Homo sapiens_hsa005900.67165855
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66278166
85Oocyte meiosis_Homo sapiens_hsa041140.64412114
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63722340
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62289358
88Salmonella infection_Homo sapiens_hsa051320.60939043
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59498972
90Fatty acid elongation_Homo sapiens_hsa000620.59360614
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58469860
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.56582105
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55293100
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53675919
95Regulation of autophagy_Homo sapiens_hsa041400.52772338
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.50605519
97Salivary secretion_Homo sapiens_hsa049700.49504076
98mTOR signaling pathway_Homo sapiens_hsa041500.48353354
99Estrogen signaling pathway_Homo sapiens_hsa049150.47215201
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46936338
101Arginine and proline metabolism_Homo sapiens_hsa003300.46548961
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46326194
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.44816247
104Linoleic acid metabolism_Homo sapiens_hsa005910.43652438
105Sphingolipid metabolism_Homo sapiens_hsa006000.43173876
106Biosynthesis of amino acids_Homo sapiens_hsa012300.42292461
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42170604
108T cell receptor signaling pathway_Homo sapiens_hsa046600.41677915
109ErbB signaling pathway_Homo sapiens_hsa040120.41612714
110N-Glycan biosynthesis_Homo sapiens_hsa005100.41330341
111VEGF signaling pathway_Homo sapiens_hsa043700.41293940
112Notch signaling pathway_Homo sapiens_hsa043300.40951236
113Oxytocin signaling pathway_Homo sapiens_hsa049210.40217680
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39611017
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.39332623
116Hepatitis C_Homo sapiens_hsa051600.38943407
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.38390379
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38290610
119Glioma_Homo sapiens_hsa052140.37928997
120Axon guidance_Homo sapiens_hsa043600.37377771
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37232669
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37039937
123Glutamatergic synapse_Homo sapiens_hsa047240.36946510
124Vibrio cholerae infection_Homo sapiens_hsa051100.36501557
125Vitamin digestion and absorption_Homo sapiens_hsa049770.33042898
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32344995
127Systemic lupus erythematosus_Homo sapiens_hsa053220.31847053
128Carbon metabolism_Homo sapiens_hsa012000.31282204
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29427360
130Ether lipid metabolism_Homo sapiens_hsa005650.27891523
131Pyruvate metabolism_Homo sapiens_hsa006200.23086071
132Rheumatoid arthritis_Homo sapiens_hsa053230.21096626
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19362198
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18322154
135Selenocompound metabolism_Homo sapiens_hsa004500.16956881
136Fructose and mannose metabolism_Homo sapiens_hsa000510.16354677
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16102373
138Phototransduction_Homo sapiens_hsa047440.15739155
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.15719269
140Tyrosine metabolism_Homo sapiens_hsa003500.14895182
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13200079
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12800622
143Phenylalanine metabolism_Homo sapiens_hsa003600.12468220
144Autoimmune thyroid disease_Homo sapiens_hsa053200.12451408
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10791511
146Herpes simplex infection_Homo sapiens_hsa051680.10263120
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10257757
148Sulfur metabolism_Homo sapiens_hsa009200.09468071
149Hedgehog signaling pathway_Homo sapiens_hsa043400.08133677
150Histidine metabolism_Homo sapiens_hsa003400.07878188
151Type I diabetes mellitus_Homo sapiens_hsa049400.06879345
152beta-Alanine metabolism_Homo sapiens_hsa004100.06869232
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.05294124
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04829542
155Galactose metabolism_Homo sapiens_hsa000520.04608759
156Propanoate metabolism_Homo sapiens_hsa006400.04068958
157Peroxisome_Homo sapiens_hsa041460.02512189
158Viral carcinogenesis_Homo sapiens_hsa052030.01691542
159Alcoholism_Homo sapiens_hsa050340.01114175
160Butanoate metabolism_Homo sapiens_hsa006500.00769668
161Chemical carcinogenesis_Homo sapiens_hsa05204-0.0153749

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