

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.68668648 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.63610083 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.37500325 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.37500325 |
| 5 | protein neddylation (GO:0045116) | 5.25949422 |
| 6 | termination of RNA polymerase III transcription (GO:0006386) | 4.88540026 |
| 7 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.88540026 |
| 8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.73399798 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.57658491 |
| 10 | 7-methylguanosine mRNA capping (GO:0006370) | 4.45433301 |
| 11 | proteasome assembly (GO:0043248) | 4.42350052 |
| 12 | RNA capping (GO:0036260) | 4.39142488 |
| 13 | 7-methylguanosine RNA capping (GO:0009452) | 4.39142488 |
| 14 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.29155487 |
| 15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.29155487 |
| 16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.29155487 |
| 17 | axon ensheathment in central nervous system (GO:0032291) | 4.24422879 |
| 18 | central nervous system myelination (GO:0022010) | 4.24422879 |
| 19 | protein complex biogenesis (GO:0070271) | 4.17669174 |
| 20 | GTP biosynthetic process (GO:0006183) | 4.04720653 |
| 21 | respiratory electron transport chain (GO:0022904) | 3.93188382 |
| 22 | electron transport chain (GO:0022900) | 3.83773725 |
| 23 | cullin deneddylation (GO:0010388) | 3.73402190 |
| 24 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.71692680 |
| 25 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.71655684 |
| 26 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.71534416 |
| 27 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.68370471 |
| 28 | ribosomal small subunit biogenesis (GO:0042274) | 3.67052265 |
| 29 | intraciliary transport (GO:0042073) | 3.62442529 |
| 30 | protein deneddylation (GO:0000338) | 3.61214184 |
| 31 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.58684664 |
| 32 | cytochrome complex assembly (GO:0017004) | 3.51939212 |
| 33 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.51388352 |
| 34 | regulation of cilium movement (GO:0003352) | 3.48273678 |
| 35 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.45911993 |
| 36 | long-chain fatty acid biosynthetic process (GO:0042759) | 3.44732647 |
| 37 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.42898661 |
| 38 | UTP biosynthetic process (GO:0006228) | 3.41608716 |
| 39 | termination of RNA polymerase I transcription (GO:0006363) | 3.36290789 |
| 40 | platelet dense granule organization (GO:0060155) | 3.33611458 |
| 41 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.32637985 |
| 42 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.31589610 |
| 43 | mannosylation (GO:0097502) | 3.29986718 |
| 44 | nonmotile primary cilium assembly (GO:0035058) | 3.29808606 |
| 45 | protein targeting to mitochondrion (GO:0006626) | 3.27239600 |
| 46 | protein localization to cilium (GO:0061512) | 3.27001064 |
| 47 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.26360647 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.25883420 |
| 49 | negative regulation of ligase activity (GO:0051352) | 3.25883420 |
| 50 | transcription from RNA polymerase I promoter (GO:0006360) | 3.23435138 |
| 51 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.23214879 |
| 52 | DNA deamination (GO:0045006) | 3.19237452 |
| 53 | establishment of protein localization to mitochondrion (GO:0072655) | 3.18609193 |
| 54 | spliceosomal complex assembly (GO:0000245) | 3.15605328 |
| 55 | DNA-templated transcription, elongation (GO:0006354) | 3.14196684 |
| 56 | maturation of SSU-rRNA (GO:0030490) | 3.12289885 |
| 57 | fatty acid elongation (GO:0030497) | 3.11026932 |
| 58 | replication fork processing (GO:0031297) | 3.10053772 |
| 59 | protein-cofactor linkage (GO:0018065) | 3.07190163 |
| 60 | respiratory chain complex IV assembly (GO:0008535) | 3.05042517 |
| 61 | rRNA modification (GO:0000154) | 3.04700399 |
| 62 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.04233312 |
| 63 | behavioral response to nicotine (GO:0035095) | 3.01520539 |
| 64 | regulation of mitochondrial translation (GO:0070129) | 2.98683856 |
| 65 | peptidyl-histidine modification (GO:0018202) | 2.98492976 |
| 66 | inositol phosphate catabolic process (GO:0071545) | 2.98468550 |
| 67 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.94632808 |
| 68 | L-methionine salvage (GO:0071267) | 2.91763571 |
| 69 | L-methionine biosynthetic process (GO:0071265) | 2.91763571 |
| 70 | amino acid salvage (GO:0043102) | 2.91763571 |
| 71 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.91090933 |
| 72 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 2.90837470 |
| 73 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.90359501 |
| 74 | response to pheromone (GO:0019236) | 2.90180471 |
| 75 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.87385894 |
| 76 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.87385894 |
| 77 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.87385894 |
| 78 | positive regulation of viral transcription (GO:0050434) | 2.87223394 |
| 79 | protein localization to mitochondrion (GO:0070585) | 2.86697031 |
| 80 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.86680572 |
| 81 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.86680572 |
| 82 | epithelial cilium movement (GO:0003351) | 2.86648947 |
| 83 | GPI anchor biosynthetic process (GO:0006506) | 2.83845010 |
| 84 | response to redox state (GO:0051775) | 2.82550042 |
| 85 | positive regulation of ligase activity (GO:0051351) | 2.82334393 |
| 86 | sequestering of actin monomers (GO:0042989) | 2.82001017 |
| 87 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.81278218 |
| 88 | cellular component biogenesis (GO:0044085) | 2.81197453 |
| 89 | keratinocyte development (GO:0003334) | 2.80480873 |
| 90 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 2.80154967 |
| 91 | inositol phosphate dephosphorylation (GO:0046855) | 2.80154967 |
| 92 | microtubule polymerization or depolymerization (GO:0031109) | 2.80035770 |
| 93 | cotranslational protein targeting to membrane (GO:0006613) | 2.79051056 |
| 94 | positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) | 2.78513974 |
| 95 | hydrogen ion transmembrane transport (GO:1902600) | 2.78299242 |
| 96 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.77513343 |
| 97 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.77513343 |
| 98 | spliceosomal snRNP assembly (GO:0000387) | 2.77308710 |
| 99 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.76316269 |
| 100 | anterograde synaptic vesicle transport (GO:0048490) | 2.75703206 |
| 101 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.75313271 |
| 102 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.74779921 |
| 103 | inner mitochondrial membrane organization (GO:0007007) | 2.72936700 |
| 104 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.72705635 |
| 105 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.72705188 |
| 106 | intracellular protein transmembrane import (GO:0044743) | 2.72333091 |
| 107 | ATP biosynthetic process (GO:0006754) | 2.71915043 |
| 108 | CTP metabolic process (GO:0046036) | 2.71771129 |
| 109 | CTP biosynthetic process (GO:0006241) | 2.71771129 |
| 110 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.71400215 |
| 111 | DNA double-strand break processing (GO:0000729) | 2.71032784 |
| 112 | resolution of meiotic recombination intermediates (GO:0000712) | 2.70575714 |
| 113 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.70256945 |
| 114 | pseudouridine synthesis (GO:0001522) | 2.70044200 |
| 115 | establishment of integrated proviral latency (GO:0075713) | 2.69895129 |
| 116 | UTP metabolic process (GO:0046051) | 2.69297117 |
| 117 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.68686744 |
| 118 | GMP metabolic process (GO:0046037) | 2.68495775 |
| 119 | protein targeting to ER (GO:0045047) | 2.68378466 |
| 120 | viral transcription (GO:0019083) | 2.68363106 |
| 121 | protein K6-linked ubiquitination (GO:0085020) | 2.67437064 |
| 122 | establishment of viral latency (GO:0019043) | 2.66964056 |
| 123 | blastocyst development (GO:0001824) | 2.66480322 |
| 124 | translation (GO:0006412) | 2.64469311 |
| 125 | microtubule depolymerization (GO:0007019) | 2.63824322 |
| 126 | translational termination (GO:0006415) | 2.62791370 |
| 127 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.62715037 |
| 128 | transcription from RNA polymerase III promoter (GO:0006383) | 2.62544345 |
| 129 | cilium morphogenesis (GO:0060271) | 2.62436002 |
| 130 | protein localization to endoplasmic reticulum (GO:0070972) | 2.62073281 |
| 131 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.61578785 |
| 132 | tRNA processing (GO:0008033) | 2.60238130 |
| 133 | axoneme assembly (GO:0035082) | 2.59848737 |
| 134 | proton transport (GO:0015992) | 2.58996676 |
| 135 | chromatin remodeling at centromere (GO:0031055) | 2.57922103 |
| 136 | cilium organization (GO:0044782) | 2.57696075 |
| 137 | rRNA methylation (GO:0031167) | 2.56974131 |
| 138 | negative regulation of telomere maintenance (GO:0032205) | 2.54846727 |
| 139 | negative regulation of membrane potential (GO:0045837) | 2.54144304 |
| 140 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 2.53541938 |
| 141 | hydrogen transport (GO:0006818) | 2.53287970 |
| 142 | organelle disassembly (GO:1903008) | 2.51227517 |
| 143 | C-terminal protein lipidation (GO:0006501) | 2.50815102 |
| 144 | cilium assembly (GO:0042384) | 2.50374601 |
| 145 | presynaptic membrane assembly (GO:0097105) | 2.50140457 |
| 146 | kinetochore assembly (GO:0051382) | 2.46473331 |
| 147 | oxidative phosphorylation (GO:0006119) | 2.45646755 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.74110160 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.74069683 |
| 3 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.05756557 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.94337734 |
| 5 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.92718155 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.73010837 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.40144375 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.15634377 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.09077512 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.04543230 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.82779063 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.78619233 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.65169757 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.56948719 |
| 15 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.42405537 |
| 16 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.23161912 |
| 17 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.14013513 |
| 18 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.11204720 |
| 19 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.03207096 |
| 20 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02694816 |
| 21 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.95737464 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.90816422 |
| 23 | VDR_22108803_ChIP-Seq_LS180_Human | 1.88676616 |
| 24 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.87279478 |
| 25 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.83128092 |
| 26 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.79799307 |
| 27 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.76664991 |
| 28 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.70743700 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68388112 |
| 30 | FUS_26573619_Chip-Seq_HEK293_Human | 1.68202692 |
| 31 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.64924049 |
| 32 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.63464615 |
| 33 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.58796390 |
| 34 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.56653543 |
| 35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.55816254 |
| 36 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.55770657 |
| 37 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.54895213 |
| 38 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.54487565 |
| 39 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.53416401 |
| 40 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.53298693 |
| 41 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.52019726 |
| 42 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.51034800 |
| 43 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.50712901 |
| 44 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.49398310 |
| 45 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.49309476 |
| 46 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.46992272 |
| 47 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.42931221 |
| 48 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.42313768 |
| 49 | EWS_26573619_Chip-Seq_HEK293_Human | 1.42299251 |
| 50 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.42059699 |
| 51 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.39097385 |
| 52 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.38610675 |
| 53 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.38044112 |
| 54 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.37739646 |
| 55 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.36732392 |
| 56 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.35088631 |
| 57 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.34772379 |
| 58 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.28025958 |
| 59 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.27309782 |
| 60 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.26081131 |
| 61 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.25619818 |
| 62 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.24894430 |
| 63 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.22146536 |
| 64 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.22008063 |
| 65 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.21356308 |
| 66 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.19792316 |
| 67 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19727467 |
| 68 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.16730325 |
| 69 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.16730325 |
| 70 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.16635188 |
| 71 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.16123728 |
| 72 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.15044862 |
| 73 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.15044862 |
| 74 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.14516890 |
| 75 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.14065288 |
| 76 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.13875180 |
| 77 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.13516603 |
| 78 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.12989540 |
| 79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.12745943 |
| 80 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.12601927 |
| 81 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.12135945 |
| 82 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.09630446 |
| 83 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.07206333 |
| 84 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.06195408 |
| 85 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.05792190 |
| 86 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.04790777 |
| 87 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.04092884 |
| 88 | P300_19829295_ChIP-Seq_ESCs_Human | 1.01639716 |
| 89 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.01447854 |
| 90 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.00115424 |
| 91 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.99594633 |
| 92 | AR_25329375_ChIP-Seq_VCAP_Human | 0.99390466 |
| 93 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.99089106 |
| 94 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.98520487 |
| 95 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96403287 |
| 96 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.95334217 |
| 97 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94916275 |
| 98 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.93638050 |
| 99 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.92915057 |
| 100 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.92904113 |
| 101 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.92556512 |
| 102 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.92284211 |
| 103 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.92028455 |
| 104 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.91419704 |
| 105 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.91039585 |
| 106 | NCOR_22424771_ChIP-Seq_293T_Human | 0.90682870 |
| 107 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89585388 |
| 108 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.89460288 |
| 109 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.89404987 |
| 110 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.89198563 |
| 111 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.89198563 |
| 112 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.87143746 |
| 113 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.86615195 |
| 114 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.83644953 |
| 115 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82993049 |
| 116 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.82601547 |
| 117 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.80574684 |
| 118 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.79960808 |
| 119 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.79582090 |
| 120 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.78875543 |
| 121 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.78658722 |
| 122 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.77242706 |
| 123 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.76278559 |
| 124 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.76029852 |
| 125 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.75962720 |
| 126 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.74041214 |
| 127 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.73461827 |
| 128 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.73101660 |
| 129 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.73064892 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001529_abnormal_vocalization | 3.87197827 |
| 2 | MP0003880_abnormal_central_pattern | 3.04983998 |
| 3 | MP0001905_abnormal_dopamine_level | 2.91469197 |
| 4 | MP0003718_maternal_effect | 2.50322519 |
| 5 | MP0003693_abnormal_embryo_hatching | 2.36969849 |
| 6 | MP0003136_yellow_coat_color | 2.28719481 |
| 7 | MP0003787_abnormal_imprinting | 2.20040432 |
| 8 | MP0002163_abnormal_gland_morphology | 2.15121254 |
| 9 | MP0001986_abnormal_taste_sensitivity | 2.14918803 |
| 10 | MP0005084_abnormal_gallbladder_morpholo | 2.12479155 |
| 11 | MP0006276_abnormal_autonomic_nervous | 2.11892167 |
| 12 | MP0002837_dystrophic_cardiac_calcinosis | 2.10610822 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.03740406 |
| 14 | MP0002102_abnormal_ear_morphology | 2.01340669 |
| 15 | MP0003011_delayed_dark_adaptation | 2.00575499 |
| 16 | MP0002638_abnormal_pupillary_reflex | 1.91677226 |
| 17 | MP0009379_abnormal_foot_pigmentation | 1.89215266 |
| 18 | MP0001188_hyperpigmentation | 1.88305821 |
| 19 | MP0008877_abnormal_DNA_methylation | 1.82366249 |
| 20 | MP0008057_abnormal_DNA_replication | 1.81472948 |
| 21 | MP0001485_abnormal_pinna_reflex | 1.77025612 |
| 22 | MP0003195_calcinosis | 1.75659166 |
| 23 | MP0002734_abnormal_mechanical_nocicepti | 1.72939021 |
| 24 | MP0002272_abnormal_nervous_system | 1.72149368 |
| 25 | MP0005379_endocrine/exocrine_gland_phen | 1.71089716 |
| 26 | MP0005171_absent_coat_pigmentation | 1.67568430 |
| 27 | MP0008932_abnormal_embryonic_tissue | 1.65883377 |
| 28 | MP0003186_abnormal_redox_activity | 1.60329342 |
| 29 | MP0005646_abnormal_pituitary_gland | 1.60017442 |
| 30 | MP0003786_premature_aging | 1.58192057 |
| 31 | MP0008260_abnormal_autophagy | 1.53579654 |
| 32 | MP0004133_heterotaxia | 1.53295345 |
| 33 | MP0004270_analgesia | 1.52273778 |
| 34 | MP0003315_abnormal_perineum_morphology | 1.51390987 |
| 35 | MP0004957_abnormal_blastocyst_morpholog | 1.50673653 |
| 36 | MP0001440_abnormal_grooming_behavior | 1.50550904 |
| 37 | MP0004142_abnormal_muscle_tone | 1.50374062 |
| 38 | MP0000778_abnormal_nervous_system | 1.49790969 |
| 39 | MP0005409_darkened_coat_color | 1.49363479 |
| 40 | MP0008058_abnormal_DNA_repair | 1.48183980 |
| 41 | MP0002735_abnormal_chemical_nociception | 1.47639291 |
| 42 | MP0000516_abnormal_urinary_system | 1.46401917 |
| 43 | MP0005367_renal/urinary_system_phenotyp | 1.46401917 |
| 44 | MP0002736_abnormal_nociception_after | 1.46387913 |
| 45 | MP0001486_abnormal_startle_reflex | 1.43410163 |
| 46 | MP0002234_abnormal_pharynx_morphology | 1.42673114 |
| 47 | MP0000920_abnormal_myelination | 1.42277614 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 1.41951527 |
| 49 | MP0003938_abnormal_ear_development | 1.41500432 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 1.41435212 |
| 51 | MP0009697_abnormal_copulation | 1.40400254 |
| 52 | MP0005408_hypopigmentation | 1.38741669 |
| 53 | MP0006072_abnormal_retinal_apoptosis | 1.38366377 |
| 54 | MP0005423_abnormal_somatic_nervous | 1.38112548 |
| 55 | MP0004147_increased_porphyrin_level | 1.36202314 |
| 56 | MP0002064_seizures | 1.35717701 |
| 57 | MP0004742_abnormal_vestibular_system | 1.33423923 |
| 58 | MP0005551_abnormal_eye_electrophysiolog | 1.32165121 |
| 59 | MP0003123_paternal_imprinting | 1.30741962 |
| 60 | MP0009046_muscle_twitch | 1.30289818 |
| 61 | MP0001968_abnormal_touch/_nociception | 1.29945383 |
| 62 | MP0008789_abnormal_olfactory_epithelium | 1.29036655 |
| 63 | MP0002822_catalepsy | 1.28080146 |
| 64 | MP0001970_abnormal_pain_threshold | 1.27348366 |
| 65 | MP0010386_abnormal_urinary_bladder | 1.26062440 |
| 66 | MP0002090_abnormal_vision | 1.25678323 |
| 67 | MP0002928_abnormal_bile_duct | 1.24884526 |
| 68 | MP0003077_abnormal_cell_cycle | 1.24509420 |
| 69 | MP0001984_abnormal_olfaction | 1.24492460 |
| 70 | MP0009745_abnormal_behavioral_response | 1.24381167 |
| 71 | MP0010094_abnormal_chromosome_stability | 1.23338710 |
| 72 | MP0001293_anophthalmia | 1.22518509 |
| 73 | MP0001764_abnormal_homeostasis | 1.22209642 |
| 74 | MP0003122_maternal_imprinting | 1.22013927 |
| 75 | MP0000566_synostosis | 1.21633122 |
| 76 | MP0003806_abnormal_nucleotide_metabolis | 1.21206795 |
| 77 | MP0002233_abnormal_nose_morphology | 1.21000980 |
| 78 | MP0002938_white_spotting | 1.20950925 |
| 79 | MP0002572_abnormal_emotion/affect_behav | 1.19987747 |
| 80 | MP0002752_abnormal_somatic_nervous | 1.16979354 |
| 81 | MP0002210_abnormal_sex_determination | 1.16933568 |
| 82 | MP0000569_abnormal_digit_pigmentation | 1.16780018 |
| 83 | MP0003121_genomic_imprinting | 1.15539848 |
| 84 | MP0002184_abnormal_innervation | 1.14655546 |
| 85 | MP0000026_abnormal_inner_ear | 1.12764241 |
| 86 | MP0002751_abnormal_autonomic_nervous | 1.12091519 |
| 87 | MP0000631_abnormal_neuroendocrine_gland | 1.11206898 |
| 88 | MP0001346_abnormal_lacrimal_gland | 1.10783323 |
| 89 | MP0003111_abnormal_nucleus_morphology | 1.10265487 |
| 90 | MP0001963_abnormal_hearing_physiology | 1.09470234 |
| 91 | MP0005410_abnormal_fertilization | 1.09081259 |
| 92 | MP0000049_abnormal_middle_ear | 1.08174154 |
| 93 | MP0002095_abnormal_skin_pigmentation | 1.07384137 |
| 94 | MP0005451_abnormal_body_composition | 1.05669754 |
| 95 | MP0002733_abnormal_thermal_nociception | 1.05557688 |
| 96 | MP0001929_abnormal_gametogenesis | 1.04347891 |
| 97 | MP0002067_abnormal_sensory_capabilities | 1.04240200 |
| 98 | MP0003950_abnormal_plasma_membrane | 1.03020719 |
| 99 | MP0003635_abnormal_synaptic_transmissio | 1.02532425 |
| 100 | MP0002557_abnormal_social/conspecific_i | 1.01811639 |
| 101 | MP0008872_abnormal_physiological_respon | 1.01811026 |
| 102 | MP0000372_irregular_coat_pigmentation | 0.99963508 |
| 103 | MP0005645_abnormal_hypothalamus_physiol | 0.97807396 |
| 104 | MP0003698_abnormal_male_reproductive | 0.97264313 |
| 105 | MP0001501_abnormal_sleep_pattern | 0.96908553 |
| 106 | MP0002160_abnormal_reproductive_system | 0.96780649 |
| 107 | MP0008875_abnormal_xenobiotic_pharmacok | 0.96281026 |
| 108 | MP0002882_abnormal_neuron_morphology | 0.95163760 |
| 109 | MP0002876_abnormal_thyroid_physiology | 0.95140640 |
| 110 | MP0004924_abnormal_behavior | 0.95074866 |
| 111 | MP0005386_behavior/neurological_phenoty | 0.95074866 |
| 112 | MP0001542_abnormal_bone_strength | 0.94651370 |
| 113 | MP0005253_abnormal_eye_physiology | 0.94261139 |
| 114 | MP0000427_abnormal_hair_cycle | 0.94032578 |
| 115 | MP0003890_abnormal_embryonic-extraembry | 0.93546803 |
| 116 | MP0005195_abnormal_posterior_eye | 0.93381245 |
| 117 | MP0005174_abnormal_tail_pigmentation | 0.92701614 |
| 118 | MP0001145_abnormal_male_reproductive | 0.91625897 |
| 119 | MP0008007_abnormal_cellular_replicative | 0.91376782 |
| 120 | MP0002229_neurodegeneration | 0.90237537 |
| 121 | MP0000653_abnormal_sex_gland | 0.89115194 |
| 122 | MP0010030_abnormal_orbit_morphology | 0.88518144 |
| 123 | MP0005499_abnormal_olfactory_system | 0.86534109 |
| 124 | MP0005394_taste/olfaction_phenotype | 0.86534109 |
| 125 | MP0008995_early_reproductive_senescence | 0.86143530 |
| 126 | MP0001502_abnormal_circadian_rhythm | 0.85948329 |
| 127 | * MP0003937_abnormal_limbs/digits/tail_de | 0.84276019 |
| 128 | MP0003755_abnormal_palate_morphology | 0.83933876 |
| 129 | MP0002277_abnormal_respiratory_mucosa | 0.83642620 |
| 130 | MP0002653_abnormal_ependyma_morphology | 0.83145201 |
| 131 | MP0002063_abnormal_learning/memory/cond | 0.83093059 |
| 132 | MP0005391_vision/eye_phenotype | 0.80916532 |
| 133 | MP0003634_abnormal_glial_cell | 0.80842918 |
| 134 | MP0004043_abnormal_pH_regulation | 0.80598050 |
| 135 | MP0005389_reproductive_system_phenotype | 0.80289095 |
| 136 | MP0001324_abnormal_eye_pigmentation | 0.80100814 |
| 137 | MP0000462_abnormal_digestive_system | 0.80056726 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.99457598 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.28910830 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.28757586 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.04829659 |
| 5 | 3-Methylglutaconic aciduria (HP:0003535) | 3.81818329 |
| 6 | Acute encephalopathy (HP:0006846) | 3.68606139 |
| 7 | Increased CSF lactate (HP:0002490) | 3.59926071 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.55467597 |
| 9 | Cerebral hypomyelination (HP:0006808) | 3.54246100 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.51788665 |
| 11 | Abnormality of glycolysis (HP:0004366) | 3.38406488 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.38406488 |
| 13 | Renal Fanconi syndrome (HP:0001994) | 3.35503376 |
| 14 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.31277734 |
| 15 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.10545621 |
| 16 | Nephronophthisis (HP:0000090) | 3.05770841 |
| 17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.93408318 |
| 18 | Lipid accumulation in hepatocytes (HP:0006561) | 2.88506364 |
| 19 | Medial flaring of the eyebrow (HP:0010747) | 2.77023177 |
| 20 | Sclerocornea (HP:0000647) | 2.73393578 |
| 21 | Leukodystrophy (HP:0002415) | 2.71202221 |
| 22 | Hepatic necrosis (HP:0002605) | 2.70379610 |
| 23 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.68184804 |
| 24 | Birth length less than 3rd percentile (HP:0003561) | 2.63137389 |
| 25 | Gait imbalance (HP:0002141) | 2.61228242 |
| 26 | Pancreatic fibrosis (HP:0100732) | 2.60433723 |
| 27 | Optic disc pallor (HP:0000543) | 2.59862117 |
| 28 | Abnormal ciliary motility (HP:0012262) | 2.56191263 |
| 29 | Congenital primary aphakia (HP:0007707) | 2.54289979 |
| 30 | Abnormality of the renal medulla (HP:0100957) | 2.50842115 |
| 31 | Parakeratosis (HP:0001036) | 2.49003547 |
| 32 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.48031966 |
| 33 | Exercise intolerance (HP:0003546) | 2.47908738 |
| 34 | Congenital, generalized hypertrichosis (HP:0004540) | 2.46985502 |
| 35 | Increased serum lactate (HP:0002151) | 2.45297267 |
| 36 | Breast hypoplasia (HP:0003187) | 2.44476419 |
| 37 | Nephrogenic diabetes insipidus (HP:0009806) | 2.44416704 |
| 38 | Methylmalonic acidemia (HP:0002912) | 2.43246391 |
| 39 | Respiratory failure (HP:0002878) | 2.39253276 |
| 40 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.38927964 |
| 41 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.38927964 |
| 42 | Exertional dyspnea (HP:0002875) | 2.38409609 |
| 43 | Abnormality of renal resorption (HP:0011038) | 2.35079828 |
| 44 | Abnormality of the labia minora (HP:0012880) | 2.34899202 |
| 45 | Genital tract atresia (HP:0001827) | 2.33459823 |
| 46 | Vaginal atresia (HP:0000148) | 2.32021477 |
| 47 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.31401325 |
| 48 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.28964329 |
| 49 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.28964329 |
| 50 | Type II lissencephaly (HP:0007260) | 2.28454729 |
| 51 | Colon cancer (HP:0003003) | 2.26757939 |
| 52 | Stenosis of the external auditory canal (HP:0000402) | 2.23878631 |
| 53 | Sensory axonal neuropathy (HP:0003390) | 2.21106635 |
| 54 | Adrenal hypoplasia (HP:0000835) | 2.20597823 |
| 55 | Pancreatic cysts (HP:0001737) | 2.19351671 |
| 56 | Hyperglycinemia (HP:0002154) | 2.19330242 |
| 57 | Respiratory difficulties (HP:0002880) | 2.19247486 |
| 58 | CNS hypomyelination (HP:0003429) | 2.16950309 |
| 59 | Hypothermia (HP:0002045) | 2.15626534 |
| 60 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.15587202 |
| 61 | Lactic acidosis (HP:0003128) | 2.15116089 |
| 62 | Anencephaly (HP:0002323) | 2.14802131 |
| 63 | Postaxial foot polydactyly (HP:0001830) | 2.14727776 |
| 64 | Molar tooth sign on MRI (HP:0002419) | 2.14655214 |
| 65 | Abnormality of midbrain morphology (HP:0002418) | 2.14655214 |
| 66 | Male pseudohermaphroditism (HP:0000037) | 2.14453993 |
| 67 | True hermaphroditism (HP:0010459) | 2.14396914 |
| 68 | Type 2 muscle fiber atrophy (HP:0003554) | 2.13177866 |
| 69 | Irregular epiphyses (HP:0010582) | 2.09042425 |
| 70 | Increased intramyocellular lipid droplets (HP:0012240) | 2.08893046 |
| 71 | Pendular nystagmus (HP:0012043) | 2.08227171 |
| 72 | Cerebral edema (HP:0002181) | 2.07156980 |
| 73 | Abnormality of the renal cortex (HP:0011035) | 2.06615700 |
| 74 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.06216043 |
| 75 | Methylmalonic aciduria (HP:0012120) | 2.05461497 |
| 76 | Rhinitis (HP:0012384) | 2.04779438 |
| 77 | Postaxial hand polydactyly (HP:0001162) | 1.99760521 |
| 78 | Congenital stationary night blindness (HP:0007642) | 1.99370195 |
| 79 | Volvulus (HP:0002580) | 1.98667670 |
| 80 | Split foot (HP:0001839) | 1.98625949 |
| 81 | Abnormal hair whorl (HP:0010721) | 1.98311067 |
| 82 | Abolished electroretinogram (ERG) (HP:0000550) | 1.97474372 |
| 83 | Neoplasm of the adrenal cortex (HP:0100641) | 1.97327835 |
| 84 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.96954064 |
| 85 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.96954064 |
| 86 | Abnormal protein glycosylation (HP:0012346) | 1.96954064 |
| 87 | Abnormal glycosylation (HP:0012345) | 1.96954064 |
| 88 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.96762563 |
| 89 | Rough bone trabeculation (HP:0100670) | 1.96495922 |
| 90 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.95851973 |
| 91 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.95851973 |
| 92 | Poor coordination (HP:0002370) | 1.94998647 |
| 93 | Lethargy (HP:0001254) | 1.94848551 |
| 94 | Microvesicular hepatic steatosis (HP:0001414) | 1.93253961 |
| 95 | Muscle fiber atrophy (HP:0100295) | 1.91859820 |
| 96 | Abnormality of urine glucose concentration (HP:0011016) | 1.90454299 |
| 97 | Glycosuria (HP:0003076) | 1.90454299 |
| 98 | Optic nerve hypoplasia (HP:0000609) | 1.89821508 |
| 99 | Carpal bone hypoplasia (HP:0001498) | 1.89079339 |
| 100 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.88352376 |
| 101 | Macrocytic anemia (HP:0001972) | 1.88176365 |
| 102 | Renal cortical cysts (HP:0000803) | 1.87799988 |
| 103 | Abnormality of the septum pellucidum (HP:0007375) | 1.86643115 |
| 104 | Delusions (HP:0000746) | 1.85883790 |
| 105 | Short tibia (HP:0005736) | 1.85122251 |
| 106 | Abnormal number of erythroid precursors (HP:0012131) | 1.84912515 |
| 107 | Cystic liver disease (HP:0006706) | 1.84822814 |
| 108 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.84072155 |
| 109 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.83323730 |
| 110 | Reticulocytopenia (HP:0001896) | 1.82889521 |
| 111 | Limb dystonia (HP:0002451) | 1.81376418 |
| 112 | CNS demyelination (HP:0007305) | 1.81127994 |
| 113 | Congenital hepatic fibrosis (HP:0002612) | 1.79310409 |
| 114 | Cerebellar dysplasia (HP:0007033) | 1.79299679 |
| 115 | Absent septum pellucidum (HP:0001331) | 1.79144277 |
| 116 | Bifid tongue (HP:0010297) | 1.79108359 |
| 117 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.78433949 |
| 118 | Supernumerary spleens (HP:0009799) | 1.77987363 |
| 119 | Duplicated collecting system (HP:0000081) | 1.77908121 |
| 120 | Chronic hepatic failure (HP:0100626) | 1.77755839 |
| 121 | Abnormality of methionine metabolism (HP:0010901) | 1.77531068 |
| 122 | Absent radius (HP:0003974) | 1.76882586 |
| 123 | Secondary amenorrhea (HP:0000869) | 1.76334067 |
| 124 | Occipital encephalocele (HP:0002085) | 1.76132709 |
| 125 | Septo-optic dysplasia (HP:0100842) | 1.75653991 |
| 126 | Oligodactyly (hands) (HP:0001180) | 1.75634796 |
| 127 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.74484937 |
| 128 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.74481242 |
| 129 | Preaxial hand polydactyly (HP:0001177) | 1.73716655 |
| 130 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.73181116 |
| 131 | Absent/shortened dynein arms (HP:0200106) | 1.73181116 |
| 132 | Hypoplasia of the pons (HP:0012110) | 1.72862573 |
| 133 | Aganglionic megacolon (HP:0002251) | 1.72806851 |
| 134 | Abnormality of the pons (HP:0007361) | 1.71753969 |
| 135 | Aplasia involving forearm bones (HP:0009822) | 1.70874570 |
| 136 | Absent forearm bone (HP:0003953) | 1.70874570 |
| 137 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.70263911 |
| 138 | Retinal dysplasia (HP:0007973) | 1.70145149 |
| 139 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.70102909 |
| 140 | X-linked dominant inheritance (HP:0001423) | 1.70064759 |
| 141 | Emotional lability (HP:0000712) | 1.69939620 |
| 142 | Type I transferrin isoform profile (HP:0003642) | 1.69768370 |
| 143 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.69430176 |
| 144 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.67924905 |
| 145 | Absent epiphyses (HP:0010577) | 1.67924905 |
| 146 | Abnormal autonomic nervous system physiology (HP:0012332) | 1.67482833 |
| 147 | Median cleft lip (HP:0000161) | 1.67035323 |
| 148 | Abnormality of the axillary hair (HP:0100134) | 1.66155493 |
| 149 | Abnormality of secondary sexual hair (HP:0009888) | 1.66155493 |
| 150 | Hypoglycemic coma (HP:0001325) | 1.65023370 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 3.55276054 |
| 2 | FRK | 3.46419522 |
| 3 | VRK2 | 3.13977959 |
| 4 | STK16 | 3.07493142 |
| 5 | TRIM28 | 2.55571682 |
| 6 | CASK | 2.54899763 |
| 7 | NUAK1 | 2.42848653 |
| 8 | STK39 | 2.38937766 |
| 9 | MAP4K2 | 2.38685695 |
| 10 | PNCK | 2.27523911 |
| 11 | ARAF | 2.26252459 |
| 12 | BCR | 2.21428308 |
| 13 | VRK1 | 2.16214825 |
| 14 | WEE1 | 2.14178684 |
| 15 | PLK4 | 2.04697460 |
| 16 | NME1 | 1.99293214 |
| 17 | TAF1 | 1.96760933 |
| 18 | OXSR1 | 1.94314302 |
| 19 | SRPK1 | 1.92667521 |
| 20 | EIF2AK1 | 1.91782124 |
| 21 | DYRK2 | 1.91604290 |
| 22 | MUSK | 1.85251757 |
| 23 | TNIK | 1.79383390 |
| 24 | BCKDK | 1.77716676 |
| 25 | PBK | 1.74547186 |
| 26 | MST4 | 1.72711479 |
| 27 | CCNB1 | 1.67520130 |
| 28 | EIF2AK3 | 1.63329280 |
| 29 | BMPR1B | 1.61019714 |
| 30 | BRAF | 1.56514408 |
| 31 | BMPR2 | 1.55803482 |
| 32 | MKNK2 | 1.53710691 |
| 33 | CDK19 | 1.52209426 |
| 34 | MKNK1 | 1.51524975 |
| 35 | CDK8 | 1.47641194 |
| 36 | ERBB3 | 1.37953378 |
| 37 | INSRR | 1.36276918 |
| 38 | NEK1 | 1.36079235 |
| 39 | MAP3K12 | 1.35011747 |
| 40 | NEK6 | 1.35010748 |
| 41 | AKT3 | 1.34214787 |
| 42 | TSSK6 | 1.28678005 |
| 43 | PLK3 | 1.22063773 |
| 44 | MAPK13 | 1.21617429 |
| 45 | GRK7 | 1.21251541 |
| 46 | NME2 | 1.20455283 |
| 47 | CSNK1G3 | 1.20367322 |
| 48 | MARK1 | 1.16826145 |
| 49 | PAK3 | 1.13444195 |
| 50 | MAPK15 | 1.12989910 |
| 51 | MAP2K7 | 1.09673947 |
| 52 | CAMKK2 | 1.06008439 |
| 53 | ACVR1B | 1.01270848 |
| 54 | WNK4 | 0.99160221 |
| 55 | LIMK1 | 0.97739208 |
| 56 | PLK2 | 0.95950455 |
| 57 | DYRK3 | 0.94382594 |
| 58 | BRSK2 | 0.93389722 |
| 59 | CSNK1G1 | 0.91751855 |
| 60 | FGFR2 | 0.91068198 |
| 61 | CDK3 | 0.87584233 |
| 62 | UHMK1 | 0.87062428 |
| 63 | CAMK2B | 0.84394882 |
| 64 | ADRBK2 | 0.84041658 |
| 65 | GRK1 | 0.81900558 |
| 66 | MAPKAPK5 | 0.81847953 |
| 67 | AURKA | 0.80649310 |
| 68 | PLK1 | 0.79835357 |
| 69 | PIM2 | 0.78454065 |
| 70 | PKN1 | 0.77367936 |
| 71 | RPS6KA5 | 0.74463274 |
| 72 | TLK1 | 0.72028546 |
| 73 | TTK | 0.71768391 |
| 74 | WNK3 | 0.71397462 |
| 75 | CSNK1G2 | 0.67338067 |
| 76 | CHEK2 | 0.67325990 |
| 77 | CSNK1A1L | 0.64205995 |
| 78 | CAMK2D | 0.63321896 |
| 79 | ZAK | 0.63143407 |
| 80 | PRPF4B | 0.63035074 |
| 81 | EIF2AK2 | 0.62809158 |
| 82 | CAMK2A | 0.61602478 |
| 83 | ERBB4 | 0.60277762 |
| 84 | STK38L | 0.59900070 |
| 85 | GRK5 | 0.59498831 |
| 86 | DAPK1 | 0.57385880 |
| 87 | IRAK1 | 0.56554633 |
| 88 | DYRK1A | 0.55674005 |
| 89 | NTRK3 | 0.54094337 |
| 90 | MINK1 | 0.53825234 |
| 91 | CAMK2G | 0.53824954 |
| 92 | EPHB2 | 0.53690233 |
| 93 | PHKG2 | 0.52602711 |
| 94 | PHKG1 | 0.52602711 |
| 95 | YES1 | 0.51804807 |
| 96 | TESK2 | 0.50682286 |
| 97 | PDK2 | 0.50379658 |
| 98 | MAP3K4 | 0.49175744 |
| 99 | CSNK1A1 | 0.48757230 |
| 100 | MYLK | 0.48561791 |
| 101 | FGR | 0.47723097 |
| 102 | CSNK2A1 | 0.47666413 |
| 103 | PRKCE | 0.47216678 |
| 104 | IRAK2 | 0.46874689 |
| 105 | PINK1 | 0.46248522 |
| 106 | PRKCG | 0.45005950 |
| 107 | ABL2 | 0.44037682 |
| 108 | EPHA4 | 0.43272275 |
| 109 | AURKB | 0.43177052 |
| 110 | CDK14 | 0.41913542 |
| 111 | PRKCI | 0.41749528 |
| 112 | IRAK4 | 0.41008447 |
| 113 | CDC7 | 0.40970652 |
| 114 | RPS6KA4 | 0.40952957 |
| 115 | PTK2B | 0.40440334 |
| 116 | CSNK2A2 | 0.39852014 |
| 117 | NLK | 0.38796197 |
| 118 | NTRK2 | 0.38285578 |
| 119 | CDK18 | 0.37979675 |
| 120 | ATR | 0.37613133 |
| 121 | BRSK1 | 0.37316463 |
| 122 | SIK3 | 0.36921439 |
| 123 | IRAK3 | 0.36708649 |
| 124 | ADRBK1 | 0.36486151 |
| 125 | OBSCN | 0.36005996 |
| 126 | PRKACA | 0.35311839 |
| 127 | STK11 | 0.35039737 |
| 128 | DAPK3 | 0.32305908 |
| 129 | ATM | 0.32251448 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RNA polymerase_Homo sapiens_hsa03020 | 4.34989545 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.21027895 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.92744478 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.51412222 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.46673699 |
| 6 | Protein export_Homo sapiens_hsa03060 | 3.20433097 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.79624367 |
| 8 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.57851997 |
| 9 | Alzheimers disease_Homo sapiens_hsa05010 | 2.52324630 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.34762498 |
| 11 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.33521522 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.29513656 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.13637946 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.92214542 |
| 15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.90726003 |
| 16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.81320111 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.75740740 |
| 18 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.59773674 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.58418988 |
| 20 | Purine metabolism_Homo sapiens_hsa00230 | 1.53649202 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.50573228 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.48265544 |
| 23 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.48026025 |
| 24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.47787408 |
| 25 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.47515016 |
| 26 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.46437693 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.45253231 |
| 28 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.36554586 |
| 29 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.34785976 |
| 30 | Mismatch repair_Homo sapiens_hsa03430 | 1.32060533 |
| 31 | Phototransduction_Homo sapiens_hsa04744 | 1.31456389 |
| 32 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.31300222 |
| 33 | RNA degradation_Homo sapiens_hsa03018 | 1.29998358 |
| 34 | DNA replication_Homo sapiens_hsa03030 | 1.28827332 |
| 35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27983959 |
| 36 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.25723353 |
| 37 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.19953006 |
| 38 | Peroxisome_Homo sapiens_hsa04146 | 1.14334304 |
| 39 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.13448314 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.12522209 |
| 41 | Cell cycle_Homo sapiens_hsa04110 | 1.12292622 |
| 42 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.10018078 |
| 43 | Nicotine addiction_Homo sapiens_hsa05033 | 1.08684975 |
| 44 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.99480038 |
| 45 | Base excision repair_Homo sapiens_hsa03410 | 0.97667891 |
| 46 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.95569098 |
| 47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.94218097 |
| 48 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.92876028 |
| 49 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.89542457 |
| 50 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.88486648 |
| 51 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.88127315 |
| 52 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.87862376 |
| 53 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.86246684 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.85586464 |
| 55 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.85419700 |
| 56 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84395413 |
| 57 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.82502386 |
| 58 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.77532601 |
| 59 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.74532057 |
| 60 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.74385656 |
| 61 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74044255 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69477088 |
| 63 | Sulfur relay system_Homo sapiens_hsa04122 | 0.68968491 |
| 64 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.67553427 |
| 65 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.66434792 |
| 66 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.66089581 |
| 67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.65191784 |
| 68 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.64410606 |
| 69 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.63292509 |
| 70 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.60887068 |
| 71 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.60758825 |
| 72 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.60647029 |
| 73 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.60108215 |
| 74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.59665673 |
| 75 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57896521 |
| 76 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.57836341 |
| 77 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.56845331 |
| 78 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.56587638 |
| 79 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.55755971 |
| 80 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.54828496 |
| 81 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.50868537 |
| 82 | Taste transduction_Homo sapiens_hsa04742 | 0.50598934 |
| 83 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.49964712 |
| 84 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.48336379 |
| 85 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47678288 |
| 86 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.46308311 |
| 87 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46190459 |
| 88 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.44119284 |
| 89 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43445537 |
| 90 | Phagosome_Homo sapiens_hsa04145 | 0.42928723 |
| 91 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42283887 |
| 92 | GABAergic synapse_Homo sapiens_hsa04727 | 0.42208596 |
| 93 | Olfactory transduction_Homo sapiens_hsa04740 | 0.41543429 |
| 94 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.38861764 |
| 95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36465710 |
| 96 | Axon guidance_Homo sapiens_hsa04360 | 0.36183543 |
| 97 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.35166666 |
| 98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.34979288 |
| 99 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.34674259 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.34558096 |
| 101 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.33410024 |
| 102 | Allograft rejection_Homo sapiens_hsa05330 | 0.32898569 |
| 103 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.32581338 |
| 104 | Insulin secretion_Homo sapiens_hsa04911 | 0.32284918 |
| 105 | Alcoholism_Homo sapiens_hsa05034 | 0.32043132 |
| 106 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.30962216 |
| 107 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30703506 |
| 108 | Cocaine addiction_Homo sapiens_hsa05030 | 0.29079772 |
| 109 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.27245466 |
| 110 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.26254702 |
| 111 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.26101618 |
| 112 | Morphine addiction_Homo sapiens_hsa05032 | 0.25759728 |
| 113 | Long-term depression_Homo sapiens_hsa04730 | 0.25717323 |
| 114 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.24880506 |
| 115 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.24659803 |
| 116 | Asthma_Homo sapiens_hsa05310 | 0.22560631 |
| 117 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.22178358 |
| 118 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.21892952 |
| 119 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.21238811 |
| 120 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.20393020 |
| 121 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.16823032 |
| 122 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.16179541 |
| 123 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.13865763 |
| 124 | Circadian entrainment_Homo sapiens_hsa04713 | 0.13165989 |
| 125 | Histidine metabolism_Homo sapiens_hsa00340 | 0.12555469 |
| 126 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.11999704 |
| 127 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.09801257 |
| 128 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.09291393 |
| 129 | Mineral absorption_Homo sapiens_hsa04978 | 0.08913045 |
| 130 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.08610920 |

