MED31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.68668648
2chaperone-mediated protein transport (GO:0072321)5.63610083
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.37500325
4ATP synthesis coupled proton transport (GO:0015986)5.37500325
5protein neddylation (GO:0045116)5.25949422
6termination of RNA polymerase III transcription (GO:0006386)4.88540026
7transcription elongation from RNA polymerase III promoter (GO:0006385)4.88540026
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.73399798
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.57658491
107-methylguanosine mRNA capping (GO:0006370)4.45433301
11proteasome assembly (GO:0043248)4.42350052
12RNA capping (GO:0036260)4.39142488
137-methylguanosine RNA capping (GO:0009452)4.39142488
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29155487
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.29155487
16NADH dehydrogenase complex assembly (GO:0010257)4.29155487
17axon ensheathment in central nervous system (GO:0032291)4.24422879
18central nervous system myelination (GO:0022010)4.24422879
19protein complex biogenesis (GO:0070271)4.17669174
20GTP biosynthetic process (GO:0006183)4.04720653
21respiratory electron transport chain (GO:0022904)3.93188382
22electron transport chain (GO:0022900)3.83773725
23cullin deneddylation (GO:0010388)3.73402190
24mitochondrial respiratory chain complex assembly (GO:0033108)3.71692680
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71655684
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71534416
27guanosine-containing compound biosynthetic process (GO:1901070)3.68370471
28ribosomal small subunit biogenesis (GO:0042274)3.67052265
29intraciliary transport (GO:0042073)3.62442529
30protein deneddylation (GO:0000338)3.61214184
31transcription elongation from RNA polymerase I promoter (GO:0006362)3.58684664
32cytochrome complex assembly (GO:0017004)3.51939212
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51388352
34regulation of cilium movement (GO:0003352)3.48273678
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45911993
36long-chain fatty acid biosynthetic process (GO:0042759)3.44732647
37water-soluble vitamin biosynthetic process (GO:0042364)3.42898661
38UTP biosynthetic process (GO:0006228)3.41608716
39termination of RNA polymerase I transcription (GO:0006363)3.36290789
40platelet dense granule organization (GO:0060155)3.33611458
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32637985
42transcription elongation from RNA polymerase II promoter (GO:0006368)3.31589610
43mannosylation (GO:0097502)3.29986718
44nonmotile primary cilium assembly (GO:0035058)3.29808606
45protein targeting to mitochondrion (GO:0006626)3.27239600
46protein localization to cilium (GO:0061512)3.27001064
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26360647
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25883420
49negative regulation of ligase activity (GO:0051352)3.25883420
50transcription from RNA polymerase I promoter (GO:0006360)3.23435138
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23214879
52DNA deamination (GO:0045006)3.19237452
53establishment of protein localization to mitochondrion (GO:0072655)3.18609193
54spliceosomal complex assembly (GO:0000245)3.15605328
55DNA-templated transcription, elongation (GO:0006354)3.14196684
56maturation of SSU-rRNA (GO:0030490)3.12289885
57fatty acid elongation (GO:0030497)3.11026932
58replication fork processing (GO:0031297)3.10053772
59protein-cofactor linkage (GO:0018065)3.07190163
60respiratory chain complex IV assembly (GO:0008535)3.05042517
61rRNA modification (GO:0000154)3.04700399
62regulation of cellular amino acid metabolic process (GO:0006521)3.04233312
63behavioral response to nicotine (GO:0035095)3.01520539
64regulation of mitochondrial translation (GO:0070129)2.98683856
65peptidyl-histidine modification (GO:0018202)2.98492976
66inositol phosphate catabolic process (GO:0071545)2.98468550
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94632808
68L-methionine salvage (GO:0071267)2.91763571
69L-methionine biosynthetic process (GO:0071265)2.91763571
70amino acid salvage (GO:0043102)2.91763571
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91090933
72deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.90837470
73transcription initiation from RNA polymerase I promoter (GO:0006361)2.90359501
74response to pheromone (GO:0019236)2.90180471
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87385894
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87385894
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87385894
78positive regulation of viral transcription (GO:0050434)2.87223394
79protein localization to mitochondrion (GO:0070585)2.86697031
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86680572
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86680572
82epithelial cilium movement (GO:0003351)2.86648947
83GPI anchor biosynthetic process (GO:0006506)2.83845010
84response to redox state (GO:0051775)2.82550042
85positive regulation of ligase activity (GO:0051351)2.82334393
86sequestering of actin monomers (GO:0042989)2.82001017
87nucleoside diphosphate phosphorylation (GO:0006165)2.81278218
88cellular component biogenesis (GO:0044085)2.81197453
89keratinocyte development (GO:0003334)2.80480873
90phosphorylated carbohydrate dephosphorylation (GO:0046838)2.80154967
91inositol phosphate dephosphorylation (GO:0046855)2.80154967
92microtubule polymerization or depolymerization (GO:0031109)2.80035770
93cotranslational protein targeting to membrane (GO:0006613)2.79051056
94positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.78513974
95hydrogen ion transmembrane transport (GO:1902600)2.78299242
96signal transduction involved in DNA damage checkpoint (GO:0072422)2.77513343
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77513343
98spliceosomal snRNP assembly (GO:0000387)2.77308710
99pyrimidine nucleobase catabolic process (GO:0006208)2.76316269
100anterograde synaptic vesicle transport (GO:0048490)2.75703206
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75313271
102signal transduction involved in cell cycle checkpoint (GO:0072395)2.74779921
103inner mitochondrial membrane organization (GO:0007007)2.72936700
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72705635
105transcription-coupled nucleotide-excision repair (GO:0006283)2.72705188
106intracellular protein transmembrane import (GO:0044743)2.72333091
107ATP biosynthetic process (GO:0006754)2.71915043
108CTP metabolic process (GO:0046036)2.71771129
109CTP biosynthetic process (GO:0006241)2.71771129
110preassembly of GPI anchor in ER membrane (GO:0016254)2.71400215
111DNA double-strand break processing (GO:0000729)2.71032784
112resolution of meiotic recombination intermediates (GO:0000712)2.70575714
113purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70256945
114pseudouridine synthesis (GO:0001522)2.70044200
115establishment of integrated proviral latency (GO:0075713)2.69895129
116UTP metabolic process (GO:0046051)2.69297117
117SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68686744
118GMP metabolic process (GO:0046037)2.68495775
119protein targeting to ER (GO:0045047)2.68378466
120viral transcription (GO:0019083)2.68363106
121protein K6-linked ubiquitination (GO:0085020)2.67437064
122establishment of viral latency (GO:0019043)2.66964056
123blastocyst development (GO:0001824)2.66480322
124translation (GO:0006412)2.64469311
125microtubule depolymerization (GO:0007019)2.63824322
126translational termination (GO:0006415)2.62791370
127purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62715037
128transcription from RNA polymerase III promoter (GO:0006383)2.62544345
129cilium morphogenesis (GO:0060271)2.62436002
130protein localization to endoplasmic reticulum (GO:0070972)2.62073281
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61578785
132tRNA processing (GO:0008033)2.60238130
133axoneme assembly (GO:0035082)2.59848737
134proton transport (GO:0015992)2.58996676
135chromatin remodeling at centromere (GO:0031055)2.57922103
136cilium organization (GO:0044782)2.57696075
137rRNA methylation (GO:0031167)2.56974131
138negative regulation of telomere maintenance (GO:0032205)2.54846727
139negative regulation of membrane potential (GO:0045837)2.54144304
140regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53541938
141hydrogen transport (GO:0006818)2.53287970
142organelle disassembly (GO:1903008)2.51227517
143C-terminal protein lipidation (GO:0006501)2.50815102
144cilium assembly (GO:0042384)2.50374601
145presynaptic membrane assembly (GO:0097105)2.50140457
146kinetochore assembly (GO:0051382)2.46473331
147oxidative phosphorylation (GO:0006119)2.45646755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.74110160
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74069683
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.05756557
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94337734
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.92718155
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.73010837
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40144375
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15634377
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09077512
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.04543230
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82779063
12ZNF274_21170338_ChIP-Seq_K562_Hela2.78619233
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65169757
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56948719
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42405537
16* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23161912
17* MYC_18555785_ChIP-Seq_MESCs_Mouse2.14013513
18* VDR_23849224_ChIP-Seq_CD4+_Human2.11204720
19* SRF_21415370_ChIP-Seq_HL-1_Mouse2.03207096
20* ELK1_19687146_ChIP-ChIP_HELA_Human2.02694816
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95737464
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90816422
23VDR_22108803_ChIP-Seq_LS180_Human1.88676616
24TAF15_26573619_Chip-Seq_HEK293_Human1.87279478
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83128092
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.79799307
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76664991
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.70743700
29DCP1A_22483619_ChIP-Seq_HELA_Human1.68388112
30FUS_26573619_Chip-Seq_HEK293_Human1.68202692
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64924049
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63464615
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58796390
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56653543
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55816254
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55770657
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54895213
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54487565
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.53416401
40XRN2_22483619_ChIP-Seq_HELA_Human1.53298693
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52019726
42IRF1_19129219_ChIP-ChIP_H3396_Human1.51034800
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50712901
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49398310
45FOXP3_21729870_ChIP-Seq_TREG_Human1.49309476
46GBX2_23144817_ChIP-Seq_PC3_Human1.46992272
47TTF2_22483619_ChIP-Seq_HELA_Human1.42931221
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.42313768
49EWS_26573619_Chip-Seq_HEK293_Human1.42299251
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42059699
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39097385
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38610675
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.38044112
54* GABP_19822575_ChIP-Seq_HepG2_Human1.37739646
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36732392
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35088631
57TP53_22573176_ChIP-Seq_HFKS_Human1.34772379
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28025958
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27309782
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26081131
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25619818
62RNF2_27304074_Chip-Seq_NSC_Mouse1.24894430
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.22146536
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22008063
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21356308
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19792316
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19727467
68NANOG_19829295_ChIP-Seq_ESCs_Human1.16730325
69SOX2_19829295_ChIP-Seq_ESCs_Human1.16730325
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16635188
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16123728
72CBP_20019798_ChIP-Seq_JUKART_Human1.15044862
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15044862
74ER_23166858_ChIP-Seq_MCF-7_Human1.14516890
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14065288
76* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13875180
77SMAD4_21799915_ChIP-Seq_A2780_Human1.13516603
78BCAT_22108803_ChIP-Seq_LS180_Human1.12989540
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12745943
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12601927
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12135945
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09630446
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07206333
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06195408
85MYC_18940864_ChIP-ChIP_HL60_Human1.05792190
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04790777
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04092884
88P300_19829295_ChIP-Seq_ESCs_Human1.01639716
89HTT_18923047_ChIP-ChIP_STHdh_Human1.01447854
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00115424
91EZH2_22144423_ChIP-Seq_EOC_Human0.99594633
92AR_25329375_ChIP-Seq_VCAP_Human0.99390466
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.99089106
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98520487
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96403287
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95334217
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.94916275
98* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93638050
99TCF4_22108803_ChIP-Seq_LS180_Human0.92915057
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92904113
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92556512
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92284211
103MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92028455
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91419704
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.91039585
106NCOR_22424771_ChIP-Seq_293T_Human0.90682870
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.89585388
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.89460288
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89404987
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89198563
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.89198563
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87143746
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.86615195
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83644953
115REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82993049
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.82601547
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80574684
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.79960808
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79582090
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78875543
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78658722
122IGF1R_20145208_ChIP-Seq_DFB_Human0.77242706
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76278559
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76029852
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75962720
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74041214
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73461827
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73101660
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73064892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.87197827
2MP0003880_abnormal_central_pattern3.04983998
3MP0001905_abnormal_dopamine_level2.91469197
4MP0003718_maternal_effect2.50322519
5MP0003693_abnormal_embryo_hatching2.36969849
6MP0003136_yellow_coat_color2.28719481
7MP0003787_abnormal_imprinting2.20040432
8MP0002163_abnormal_gland_morphology2.15121254
9MP0001986_abnormal_taste_sensitivity2.14918803
10MP0005084_abnormal_gallbladder_morpholo2.12479155
11MP0006276_abnormal_autonomic_nervous2.11892167
12MP0002837_dystrophic_cardiac_calcinosis2.10610822
13MP0006292_abnormal_olfactory_placode2.03740406
14MP0002102_abnormal_ear_morphology2.01340669
15MP0003011_delayed_dark_adaptation2.00575499
16MP0002638_abnormal_pupillary_reflex1.91677226
17MP0009379_abnormal_foot_pigmentation1.89215266
18MP0001188_hyperpigmentation1.88305821
19MP0008877_abnormal_DNA_methylation1.82366249
20MP0008057_abnormal_DNA_replication1.81472948
21MP0001485_abnormal_pinna_reflex1.77025612
22MP0003195_calcinosis1.75659166
23MP0002734_abnormal_mechanical_nocicepti1.72939021
24MP0002272_abnormal_nervous_system1.72149368
25MP0005379_endocrine/exocrine_gland_phen1.71089716
26MP0005171_absent_coat_pigmentation1.67568430
27MP0008932_abnormal_embryonic_tissue1.65883377
28MP0003186_abnormal_redox_activity1.60329342
29MP0005646_abnormal_pituitary_gland1.60017442
30MP0003786_premature_aging1.58192057
31MP0008260_abnormal_autophagy1.53579654
32MP0004133_heterotaxia1.53295345
33MP0004270_analgesia1.52273778
34MP0003315_abnormal_perineum_morphology1.51390987
35MP0004957_abnormal_blastocyst_morpholog1.50673653
36MP0001440_abnormal_grooming_behavior1.50550904
37MP0004142_abnormal_muscle_tone1.50374062
38MP0000778_abnormal_nervous_system1.49790969
39MP0005409_darkened_coat_color1.49363479
40MP0008058_abnormal_DNA_repair1.48183980
41MP0002735_abnormal_chemical_nociception1.47639291
42MP0000516_abnormal_urinary_system1.46401917
43MP0005367_renal/urinary_system_phenotyp1.46401917
44MP0002736_abnormal_nociception_after1.46387913
45MP0001486_abnormal_startle_reflex1.43410163
46MP0002234_abnormal_pharynx_morphology1.42673114
47MP0000920_abnormal_myelination1.42277614
48MP0006035_abnormal_mitochondrial_morpho1.41951527
49MP0003938_abnormal_ear_development1.41500432
50MP0006036_abnormal_mitochondrial_physio1.41435212
51MP0009697_abnormal_copulation1.40400254
52MP0005408_hypopigmentation1.38741669
53MP0006072_abnormal_retinal_apoptosis1.38366377
54MP0005423_abnormal_somatic_nervous1.38112548
55MP0004147_increased_porphyrin_level1.36202314
56MP0002064_seizures1.35717701
57MP0004742_abnormal_vestibular_system1.33423923
58MP0005551_abnormal_eye_electrophysiolog1.32165121
59MP0003123_paternal_imprinting1.30741962
60MP0009046_muscle_twitch1.30289818
61MP0001968_abnormal_touch/_nociception1.29945383
62MP0008789_abnormal_olfactory_epithelium1.29036655
63MP0002822_catalepsy1.28080146
64MP0001970_abnormal_pain_threshold1.27348366
65MP0010386_abnormal_urinary_bladder1.26062440
66MP0002090_abnormal_vision1.25678323
67MP0002928_abnormal_bile_duct1.24884526
68MP0003077_abnormal_cell_cycle1.24509420
69MP0001984_abnormal_olfaction1.24492460
70MP0009745_abnormal_behavioral_response1.24381167
71MP0010094_abnormal_chromosome_stability1.23338710
72MP0001293_anophthalmia1.22518509
73MP0001764_abnormal_homeostasis1.22209642
74MP0003122_maternal_imprinting1.22013927
75MP0000566_synostosis1.21633122
76MP0003806_abnormal_nucleotide_metabolis1.21206795
77MP0002233_abnormal_nose_morphology1.21000980
78MP0002938_white_spotting1.20950925
79MP0002572_abnormal_emotion/affect_behav1.19987747
80MP0002752_abnormal_somatic_nervous1.16979354
81MP0002210_abnormal_sex_determination1.16933568
82MP0000569_abnormal_digit_pigmentation1.16780018
83MP0003121_genomic_imprinting1.15539848
84MP0002184_abnormal_innervation1.14655546
85MP0000026_abnormal_inner_ear1.12764241
86MP0002751_abnormal_autonomic_nervous1.12091519
87MP0000631_abnormal_neuroendocrine_gland1.11206898
88MP0001346_abnormal_lacrimal_gland1.10783323
89MP0003111_abnormal_nucleus_morphology1.10265487
90MP0001963_abnormal_hearing_physiology1.09470234
91MP0005410_abnormal_fertilization1.09081259
92MP0000049_abnormal_middle_ear1.08174154
93MP0002095_abnormal_skin_pigmentation1.07384137
94MP0005451_abnormal_body_composition1.05669754
95MP0002733_abnormal_thermal_nociception1.05557688
96MP0001929_abnormal_gametogenesis1.04347891
97MP0002067_abnormal_sensory_capabilities1.04240200
98MP0003950_abnormal_plasma_membrane1.03020719
99MP0003635_abnormal_synaptic_transmissio1.02532425
100MP0002557_abnormal_social/conspecific_i1.01811639
101MP0008872_abnormal_physiological_respon1.01811026
102MP0000372_irregular_coat_pigmentation0.99963508
103MP0005645_abnormal_hypothalamus_physiol0.97807396
104MP0003698_abnormal_male_reproductive0.97264313
105MP0001501_abnormal_sleep_pattern0.96908553
106MP0002160_abnormal_reproductive_system0.96780649
107MP0008875_abnormal_xenobiotic_pharmacok0.96281026
108MP0002882_abnormal_neuron_morphology0.95163760
109MP0002876_abnormal_thyroid_physiology0.95140640
110MP0004924_abnormal_behavior0.95074866
111MP0005386_behavior/neurological_phenoty0.95074866
112MP0001542_abnormal_bone_strength0.94651370
113MP0005253_abnormal_eye_physiology0.94261139
114MP0000427_abnormal_hair_cycle0.94032578
115MP0003890_abnormal_embryonic-extraembry0.93546803
116MP0005195_abnormal_posterior_eye0.93381245
117MP0005174_abnormal_tail_pigmentation0.92701614
118MP0001145_abnormal_male_reproductive0.91625897
119MP0008007_abnormal_cellular_replicative0.91376782
120MP0002229_neurodegeneration0.90237537
121MP0000653_abnormal_sex_gland0.89115194
122MP0010030_abnormal_orbit_morphology0.88518144
123MP0005499_abnormal_olfactory_system0.86534109
124MP0005394_taste/olfaction_phenotype0.86534109
125MP0008995_early_reproductive_senescence0.86143530
126MP0001502_abnormal_circadian_rhythm0.85948329
127* MP0003937_abnormal_limbs/digits/tail_de0.84276019
128MP0003755_abnormal_palate_morphology0.83933876
129MP0002277_abnormal_respiratory_mucosa0.83642620
130MP0002653_abnormal_ependyma_morphology0.83145201
131MP0002063_abnormal_learning/memory/cond0.83093059
132MP0005391_vision/eye_phenotype0.80916532
133MP0003634_abnormal_glial_cell0.80842918
134MP0004043_abnormal_pH_regulation0.80598050
135MP0005389_reproductive_system_phenotype0.80289095
136MP0001324_abnormal_eye_pigmentation0.80100814
137MP0000462_abnormal_digestive_system0.80056726

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.99457598
2Mitochondrial inheritance (HP:0001427)4.28910830
3Abnormal mitochondria in muscle tissue (HP:0008316)4.28757586
4Progressive macrocephaly (HP:0004481)4.04829659
53-Methylglutaconic aciduria (HP:0003535)3.81818329
6Acute encephalopathy (HP:0006846)3.68606139
7Increased CSF lactate (HP:0002490)3.59926071
8Increased hepatocellular lipid droplets (HP:0006565)3.55467597
9Cerebral hypomyelination (HP:0006808)3.54246100
10Hepatocellular necrosis (HP:0001404)3.51788665
11Abnormality of glycolysis (HP:0004366)3.38406488
12Increased serum pyruvate (HP:0003542)3.38406488
13Renal Fanconi syndrome (HP:0001994)3.35503376
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.31277734
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.10545621
16Nephronophthisis (HP:0000090)3.05770841
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93408318
18Lipid accumulation in hepatocytes (HP:0006561)2.88506364
19Medial flaring of the eyebrow (HP:0010747)2.77023177
20Sclerocornea (HP:0000647)2.73393578
21Leukodystrophy (HP:0002415)2.71202221
22Hepatic necrosis (HP:0002605)2.70379610
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.68184804
24Birth length less than 3rd percentile (HP:0003561)2.63137389
25Gait imbalance (HP:0002141)2.61228242
26Pancreatic fibrosis (HP:0100732)2.60433723
27Optic disc pallor (HP:0000543)2.59862117
28Abnormal ciliary motility (HP:0012262)2.56191263
29Congenital primary aphakia (HP:0007707)2.54289979
30Abnormality of the renal medulla (HP:0100957)2.50842115
31Parakeratosis (HP:0001036)2.49003547
32Abnormal respiratory motile cilium physiology (HP:0012261)2.48031966
33Exercise intolerance (HP:0003546)2.47908738
34Congenital, generalized hypertrichosis (HP:0004540)2.46985502
35Increased serum lactate (HP:0002151)2.45297267
36Breast hypoplasia (HP:0003187)2.44476419
37Nephrogenic diabetes insipidus (HP:0009806)2.44416704
38Methylmalonic acidemia (HP:0002912)2.43246391
39Respiratory failure (HP:0002878)2.39253276
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38927964
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38927964
42Exertional dyspnea (HP:0002875)2.38409609
43Abnormality of renal resorption (HP:0011038)2.35079828
44Abnormality of the labia minora (HP:0012880)2.34899202
45Genital tract atresia (HP:0001827)2.33459823
46Vaginal atresia (HP:0000148)2.32021477
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.31401325
48Abnormal respiratory motile cilium morphology (HP:0005938)2.28964329
49Abnormal respiratory epithelium morphology (HP:0012253)2.28964329
50Type II lissencephaly (HP:0007260)2.28454729
51Colon cancer (HP:0003003)2.26757939
52Stenosis of the external auditory canal (HP:0000402)2.23878631
53Sensory axonal neuropathy (HP:0003390)2.21106635
54Adrenal hypoplasia (HP:0000835)2.20597823
55Pancreatic cysts (HP:0001737)2.19351671
56Hyperglycinemia (HP:0002154)2.19330242
57Respiratory difficulties (HP:0002880)2.19247486
58CNS hypomyelination (HP:0003429)2.16950309
59Hypothermia (HP:0002045)2.15626534
60Abnormality of cells of the erythroid lineage (HP:0012130)2.15587202
61Lactic acidosis (HP:0003128)2.15116089
62Anencephaly (HP:0002323)2.14802131
63Postaxial foot polydactyly (HP:0001830)2.14727776
64Molar tooth sign on MRI (HP:0002419)2.14655214
65Abnormality of midbrain morphology (HP:0002418)2.14655214
66Male pseudohermaphroditism (HP:0000037)2.14453993
67True hermaphroditism (HP:0010459)2.14396914
68Type 2 muscle fiber atrophy (HP:0003554)2.13177866
69Irregular epiphyses (HP:0010582)2.09042425
70Increased intramyocellular lipid droplets (HP:0012240)2.08893046
71Pendular nystagmus (HP:0012043)2.08227171
72Cerebral edema (HP:0002181)2.07156980
73Abnormality of the renal cortex (HP:0011035)2.06615700
74Congenital ichthyosiform erythroderma (HP:0007431)2.06216043
75Methylmalonic aciduria (HP:0012120)2.05461497
76Rhinitis (HP:0012384)2.04779438
77Postaxial hand polydactyly (HP:0001162)1.99760521
78Congenital stationary night blindness (HP:0007642)1.99370195
79Volvulus (HP:0002580)1.98667670
80Split foot (HP:0001839)1.98625949
81Abnormal hair whorl (HP:0010721)1.98311067
82Abolished electroretinogram (ERG) (HP:0000550)1.97474372
83Neoplasm of the adrenal cortex (HP:0100641)1.97327835
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96954064
85Abnormal protein N-linked glycosylation (HP:0012347)1.96954064
86Abnormal protein glycosylation (HP:0012346)1.96954064
87Abnormal glycosylation (HP:0012345)1.96954064
88Aplasia/hypoplasia of the uterus (HP:0008684)1.96762563
89Rough bone trabeculation (HP:0100670)1.96495922
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95851973
91Degeneration of the lateral corticospinal tracts (HP:0002314)1.95851973
92Poor coordination (HP:0002370)1.94998647
93Lethargy (HP:0001254)1.94848551
94Microvesicular hepatic steatosis (HP:0001414)1.93253961
95Muscle fiber atrophy (HP:0100295)1.91859820
96Abnormality of urine glucose concentration (HP:0011016)1.90454299
97Glycosuria (HP:0003076)1.90454299
98Optic nerve hypoplasia (HP:0000609)1.89821508
99Carpal bone hypoplasia (HP:0001498)1.89079339
100Abnormal rod and cone electroretinograms (HP:0008323)1.88352376
101Macrocytic anemia (HP:0001972)1.88176365
102Renal cortical cysts (HP:0000803)1.87799988
103Abnormality of the septum pellucidum (HP:0007375)1.86643115
104Delusions (HP:0000746)1.85883790
105Short tibia (HP:0005736)1.85122251
106Abnormal number of erythroid precursors (HP:0012131)1.84912515
107Cystic liver disease (HP:0006706)1.84822814
108Hyperinsulinemic hypoglycemia (HP:0000825)1.84072155
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83323730
110Reticulocytopenia (HP:0001896)1.82889521
111Limb dystonia (HP:0002451)1.81376418
112CNS demyelination (HP:0007305)1.81127994
113Congenital hepatic fibrosis (HP:0002612)1.79310409
114Cerebellar dysplasia (HP:0007033)1.79299679
115Absent septum pellucidum (HP:0001331)1.79144277
116Bifid tongue (HP:0010297)1.79108359
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78433949
118Supernumerary spleens (HP:0009799)1.77987363
119Duplicated collecting system (HP:0000081)1.77908121
120Chronic hepatic failure (HP:0100626)1.77755839
121Abnormality of methionine metabolism (HP:0010901)1.77531068
122Absent radius (HP:0003974)1.76882586
123Secondary amenorrhea (HP:0000869)1.76334067
124Occipital encephalocele (HP:0002085)1.76132709
125Septo-optic dysplasia (HP:0100842)1.75653991
126Oligodactyly (hands) (HP:0001180)1.75634796
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.74484937
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74481242
129Preaxial hand polydactyly (HP:0001177)1.73716655
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.73181116
131Absent/shortened dynein arms (HP:0200106)1.73181116
132Hypoplasia of the pons (HP:0012110)1.72862573
133Aganglionic megacolon (HP:0002251)1.72806851
134Abnormality of the pons (HP:0007361)1.71753969
135Aplasia involving forearm bones (HP:0009822)1.70874570
136Absent forearm bone (HP:0003953)1.70874570
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70263911
138Retinal dysplasia (HP:0007973)1.70145149
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.70102909
140X-linked dominant inheritance (HP:0001423)1.70064759
141Emotional lability (HP:0000712)1.69939620
142Type I transferrin isoform profile (HP:0003642)1.69768370
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69430176
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67924905
145Absent epiphyses (HP:0010577)1.67924905
146Abnormal autonomic nervous system physiology (HP:0012332)1.67482833
147Median cleft lip (HP:0000161)1.67035323
148Abnormality of the axillary hair (HP:0100134)1.66155493
149Abnormality of secondary sexual hair (HP:0009888)1.66155493
150Hypoglycemic coma (HP:0001325)1.65023370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.55276054
2FRK3.46419522
3VRK23.13977959
4STK163.07493142
5TRIM282.55571682
6CASK2.54899763
7NUAK12.42848653
8STK392.38937766
9MAP4K22.38685695
10PNCK2.27523911
11ARAF2.26252459
12BCR2.21428308
13VRK12.16214825
14WEE12.14178684
15PLK42.04697460
16NME11.99293214
17TAF11.96760933
18OXSR11.94314302
19SRPK11.92667521
20EIF2AK11.91782124
21DYRK21.91604290
22MUSK1.85251757
23TNIK1.79383390
24BCKDK1.77716676
25PBK1.74547186
26MST41.72711479
27CCNB11.67520130
28EIF2AK31.63329280
29BMPR1B1.61019714
30BRAF1.56514408
31BMPR21.55803482
32MKNK21.53710691
33CDK191.52209426
34MKNK11.51524975
35CDK81.47641194
36ERBB31.37953378
37INSRR1.36276918
38NEK11.36079235
39MAP3K121.35011747
40NEK61.35010748
41AKT31.34214787
42TSSK61.28678005
43PLK31.22063773
44MAPK131.21617429
45GRK71.21251541
46NME21.20455283
47CSNK1G31.20367322
48MARK11.16826145
49PAK31.13444195
50MAPK151.12989910
51MAP2K71.09673947
52CAMKK21.06008439
53ACVR1B1.01270848
54WNK40.99160221
55LIMK10.97739208
56PLK20.95950455
57DYRK30.94382594
58BRSK20.93389722
59CSNK1G10.91751855
60FGFR20.91068198
61CDK30.87584233
62UHMK10.87062428
63CAMK2B0.84394882
64ADRBK20.84041658
65GRK10.81900558
66MAPKAPK50.81847953
67AURKA0.80649310
68PLK10.79835357
69PIM20.78454065
70PKN10.77367936
71RPS6KA50.74463274
72TLK10.72028546
73TTK0.71768391
74WNK30.71397462
75CSNK1G20.67338067
76CHEK20.67325990
77CSNK1A1L0.64205995
78CAMK2D0.63321896
79ZAK0.63143407
80PRPF4B0.63035074
81EIF2AK20.62809158
82CAMK2A0.61602478
83ERBB40.60277762
84STK38L0.59900070
85GRK50.59498831
86DAPK10.57385880
87IRAK10.56554633
88DYRK1A0.55674005
89NTRK30.54094337
90MINK10.53825234
91CAMK2G0.53824954
92EPHB20.53690233
93PHKG20.52602711
94PHKG10.52602711
95YES10.51804807
96TESK20.50682286
97PDK20.50379658
98MAP3K40.49175744
99CSNK1A10.48757230
100MYLK0.48561791
101FGR0.47723097
102CSNK2A10.47666413
103PRKCE0.47216678
104IRAK20.46874689
105PINK10.46248522
106PRKCG0.45005950
107ABL20.44037682
108EPHA40.43272275
109AURKB0.43177052
110CDK140.41913542
111PRKCI0.41749528
112IRAK40.41008447
113CDC70.40970652
114RPS6KA40.40952957
115PTK2B0.40440334
116CSNK2A20.39852014
117NLK0.38796197
118NTRK20.38285578
119CDK180.37979675
120ATR0.37613133
121BRSK10.37316463
122SIK30.36921439
123IRAK30.36708649
124ADRBK10.36486151
125OBSCN0.36005996
126PRKACA0.35311839
127STK110.35039737
128DAPK30.32305908
129ATM0.32251448

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.34989545
2Oxidative phosphorylation_Homo sapiens_hsa001904.21027895
3Proteasome_Homo sapiens_hsa030503.92744478
4Ribosome_Homo sapiens_hsa030103.51412222
5Parkinsons disease_Homo sapiens_hsa050123.46673699
6Protein export_Homo sapiens_hsa030603.20433097
7Huntingtons disease_Homo sapiens_hsa050162.79624367
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57851997
9Alzheimers disease_Homo sapiens_hsa050102.52324630
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34762498
11Vitamin B6 metabolism_Homo sapiens_hsa007502.33521522
12Basal transcription factors_Homo sapiens_hsa030222.29513656
13Pyrimidine metabolism_Homo sapiens_hsa002402.13637946
14Spliceosome_Homo sapiens_hsa030401.92214542
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90726003
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81320111
17Homologous recombination_Homo sapiens_hsa034401.75740740
18Collecting duct acid secretion_Homo sapiens_hsa049661.59773674
19Propanoate metabolism_Homo sapiens_hsa006401.58418988
20Purine metabolism_Homo sapiens_hsa002301.53649202
21Nucleotide excision repair_Homo sapiens_hsa034201.50573228
22RNA transport_Homo sapiens_hsa030131.48265544
23Steroid biosynthesis_Homo sapiens_hsa001001.48026025
24Fatty acid elongation_Homo sapiens_hsa000621.47787408
25Butanoate metabolism_Homo sapiens_hsa006501.47515016
26Ether lipid metabolism_Homo sapiens_hsa005651.46437693
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45253231
28Fanconi anemia pathway_Homo sapiens_hsa034601.36554586
29Cardiac muscle contraction_Homo sapiens_hsa042601.34785976
30Mismatch repair_Homo sapiens_hsa034301.32060533
31Phototransduction_Homo sapiens_hsa047441.31456389
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31300222
33RNA degradation_Homo sapiens_hsa030181.29998358
34DNA replication_Homo sapiens_hsa030301.28827332
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27983959
36Sphingolipid metabolism_Homo sapiens_hsa006001.25723353
37Regulation of autophagy_Homo sapiens_hsa041401.19953006
38Peroxisome_Homo sapiens_hsa041461.14334304
39Vibrio cholerae infection_Homo sapiens_hsa051101.13448314
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12522209
41Cell cycle_Homo sapiens_hsa041101.12292622
42One carbon pool by folate_Homo sapiens_hsa006701.10018078
43Nicotine addiction_Homo sapiens_hsa050331.08684975
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99480038
45Base excision repair_Homo sapiens_hsa034100.97667891
46Serotonergic synapse_Homo sapiens_hsa047260.95569098
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94218097
48Arachidonic acid metabolism_Homo sapiens_hsa005900.92876028
49Rheumatoid arthritis_Homo sapiens_hsa053230.89542457
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.88486648
51Non-homologous end-joining_Homo sapiens_hsa034500.88127315
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87862376
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86246684
54Tryptophan metabolism_Homo sapiens_hsa003800.85586464
55Linoleic acid metabolism_Homo sapiens_hsa005910.85419700
56Selenocompound metabolism_Homo sapiens_hsa004500.84395413
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82502386
58Sulfur metabolism_Homo sapiens_hsa009200.77532601
59Epstein-Barr virus infection_Homo sapiens_hsa051690.74532057
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74385656
61Oocyte meiosis_Homo sapiens_hsa041140.74044255
62Metabolic pathways_Homo sapiens_hsa011000.69477088
63Sulfur relay system_Homo sapiens_hsa041220.68968491
64Autoimmune thyroid disease_Homo sapiens_hsa053200.67553427
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66434792
66Pyruvate metabolism_Homo sapiens_hsa006200.66089581
67Chemical carcinogenesis_Homo sapiens_hsa052040.65191784
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64410606
69Caffeine metabolism_Homo sapiens_hsa002320.63292509
70Nitrogen metabolism_Homo sapiens_hsa009100.60887068
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60758825
72Folate biosynthesis_Homo sapiens_hsa007900.60647029
73Synaptic vesicle cycle_Homo sapiens_hsa047210.60108215
74Glutathione metabolism_Homo sapiens_hsa004800.59665673
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57896521
76beta-Alanine metabolism_Homo sapiens_hsa004100.57836341
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56845331
78Fatty acid metabolism_Homo sapiens_hsa012120.56587638
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55755971
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54828496
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50868537
82Taste transduction_Homo sapiens_hsa047420.50598934
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49964712
84mRNA surveillance pathway_Homo sapiens_hsa030150.48336379
85Retinol metabolism_Homo sapiens_hsa008300.47678288
86Glutamatergic synapse_Homo sapiens_hsa047240.46308311
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.46190459
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44119284
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43445537
90Phagosome_Homo sapiens_hsa041450.42928723
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42283887
92GABAergic synapse_Homo sapiens_hsa047270.42208596
93Olfactory transduction_Homo sapiens_hsa047400.41543429
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38861764
95N-Glycan biosynthesis_Homo sapiens_hsa005100.36465710
96Axon guidance_Homo sapiens_hsa043600.36183543
97Amphetamine addiction_Homo sapiens_hsa050310.35166666
98Circadian rhythm_Homo sapiens_hsa047100.34979288
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34674259
100Fatty acid degradation_Homo sapiens_hsa000710.34558096
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.33410024
102Allograft rejection_Homo sapiens_hsa053300.32898569
103Arginine and proline metabolism_Homo sapiens_hsa003300.32581338
104Insulin secretion_Homo sapiens_hsa049110.32284918
105Alcoholism_Homo sapiens_hsa050340.32043132
106p53 signaling pathway_Homo sapiens_hsa041150.30962216
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30703506
108Cocaine addiction_Homo sapiens_hsa050300.29079772
109Dopaminergic synapse_Homo sapiens_hsa047280.27245466
110Hedgehog signaling pathway_Homo sapiens_hsa043400.26254702
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26101618
112Morphine addiction_Homo sapiens_hsa050320.25759728
113Long-term depression_Homo sapiens_hsa047300.25717323
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24880506
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24659803
116Asthma_Homo sapiens_hsa053100.22560631
117Vitamin digestion and absorption_Homo sapiens_hsa049770.22178358
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21892952
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21238811
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.20393020
121Type I diabetes mellitus_Homo sapiens_hsa049400.16823032
122Tyrosine metabolism_Homo sapiens_hsa003500.16179541
123Ovarian steroidogenesis_Homo sapiens_hsa049130.13865763
124Circadian entrainment_Homo sapiens_hsa047130.13165989
125Histidine metabolism_Homo sapiens_hsa003400.12555469
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.11999704
127Ras signaling pathway_Homo sapiens_hsa040140.09801257
128Graft-versus-host disease_Homo sapiens_hsa053320.09291393
129Mineral absorption_Homo sapiens_hsa049780.08913045
130Renal cell carcinoma_Homo sapiens_hsa052110.08610920

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