

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitotic metaphase plate congression (GO:0007080) | 4.99706310 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.45550935 |
| 3 | purine nucleobase biosynthetic process (GO:0009113) | 4.40831710 |
| 4 | proteasome assembly (GO:0043248) | 4.33052777 |
| 5 | rRNA modification (GO:0000154) | 4.32989687 |
| 6 | termination of RNA polymerase III transcription (GO:0006386) | 4.32752209 |
| 7 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.32752209 |
| 8 | DNA double-strand break processing (GO:0000729) | 4.27019582 |
| 9 | CENP-A containing nucleosome assembly (GO:0034080) | 4.20014023 |
| 10 | maturation of SSU-rRNA (GO:0030490) | 4.18656635 |
| 11 | chaperone-mediated protein transport (GO:0072321) | 4.15567045 |
| 12 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.13860526 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.10505024 |
| 14 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.09881668 |
| 15 | metaphase plate congression (GO:0051310) | 4.09563934 |
| 16 | nucleobase biosynthetic process (GO:0046112) | 4.07761732 |
| 17 | 7-methylguanosine mRNA capping (GO:0006370) | 4.07456978 |
| 18 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.07444556 |
| 19 | 7-methylguanosine RNA capping (GO:0009452) | 4.03604400 |
| 20 | RNA capping (GO:0036260) | 4.03604400 |
| 21 | chromatin remodeling at centromere (GO:0031055) | 4.01507631 |
| 22 | DNA replication checkpoint (GO:0000076) | 4.00889044 |
| 23 | ribosome assembly (GO:0042255) | 3.99503407 |
| 24 | kinetochore organization (GO:0051383) | 3.96360584 |
| 25 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.94957069 |
| 26 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.90723253 |
| 27 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.90030119 |
| 28 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.88728804 |
| 29 | kinetochore assembly (GO:0051382) | 3.88476814 |
| 30 | termination of RNA polymerase I transcription (GO:0006363) | 3.86029834 |
| 31 | rRNA methylation (GO:0031167) | 3.76023177 |
| 32 | ribosome biogenesis (GO:0042254) | 3.74680005 |
| 33 | transcription from RNA polymerase I promoter (GO:0006360) | 3.74247020 |
| 34 | formation of translation preinitiation complex (GO:0001731) | 3.72426160 |
| 35 | regulation of spindle organization (GO:0090224) | 3.72124406 |
| 36 | cullin deneddylation (GO:0010388) | 3.68632137 |
| 37 | negative regulation of ligase activity (GO:0051352) | 3.68332636 |
| 38 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.68332636 |
| 39 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.68155104 |
| 40 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.66749609 |
| 41 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.66749609 |
| 42 | NADH dehydrogenase complex assembly (GO:0010257) | 3.66749609 |
| 43 | protein complex biogenesis (GO:0070271) | 3.66158011 |
| 44 | protein deneddylation (GO:0000338) | 3.65548660 |
| 45 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.65508264 |
| 46 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.65508264 |
| 47 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.63733442 |
| 48 | establishment of chromosome localization (GO:0051303) | 3.63438834 |
| 49 | ribosomal large subunit biogenesis (GO:0042273) | 3.63275683 |
| 50 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.61773330 |
| 51 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.60238110 |
| 52 | DNA replication-independent nucleosome organization (GO:0034724) | 3.60238110 |
| 53 | respiratory chain complex IV assembly (GO:0008535) | 3.59406424 |
| 54 | spindle checkpoint (GO:0031577) | 3.57548304 |
| 55 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.57448505 |
| 56 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.53016765 |
| 57 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.52999153 |
| 58 | ATP synthesis coupled proton transport (GO:0015986) | 3.52999153 |
| 59 | DNA replication initiation (GO:0006270) | 3.49965366 |
| 60 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.49733460 |
| 61 | spliceosomal snRNP assembly (GO:0000387) | 3.49672271 |
| 62 | maturation of 5.8S rRNA (GO:0000460) | 3.48501485 |
| 63 | histone exchange (GO:0043486) | 3.47173419 |
| 64 | replication fork processing (GO:0031297) | 3.45357994 |
| 65 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.45135097 |
| 66 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.42733131 |
| 67 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.41876615 |
| 68 | peptidyl-histidine modification (GO:0018202) | 3.40553167 |
| 69 | positive regulation of ligase activity (GO:0051351) | 3.40547143 |
| 70 | rRNA processing (GO:0006364) | 3.40001318 |
| 71 | protein neddylation (GO:0045116) | 3.39693045 |
| 72 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.39210203 |
| 73 | spliceosomal complex assembly (GO:0000245) | 3.37702398 |
| 74 | regulation of helicase activity (GO:0051095) | 3.36048617 |
| 75 | mitotic spindle checkpoint (GO:0071174) | 3.35946591 |
| 76 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.34485088 |
| 77 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.34185970 |
| 78 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.34185970 |
| 79 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.34185970 |
| 80 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.34005859 |
| 81 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.34005859 |
| 82 | ribosomal small subunit biogenesis (GO:0042274) | 3.33180668 |
| 83 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.32743642 |
| 84 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.32192090 |
| 85 | ribosomal small subunit assembly (GO:0000028) | 3.30450761 |
| 86 | telomere maintenance via recombination (GO:0000722) | 3.30174824 |
| 87 | rRNA metabolic process (GO:0016072) | 3.30081442 |
| 88 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.28763721 |
| 89 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.28763721 |
| 90 | negative regulation of sister chromatid segregation (GO:0033046) | 3.28763721 |
| 91 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.28763721 |
| 92 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27291704 |
| 93 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27291704 |
| 94 | mitotic nuclear envelope disassembly (GO:0007077) | 3.26957675 |
| 95 | DNA strand elongation (GO:0022616) | 3.26760428 |
| 96 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.25730361 |
| 97 | negative regulation of chromosome segregation (GO:0051985) | 3.24627579 |
| 98 | DNA-templated transcription, elongation (GO:0006354) | 3.24484292 |
| 99 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.23643456 |
| 100 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.23493333 |
| 101 | mitotic spindle assembly checkpoint (GO:0007094) | 3.21815796 |
| 102 | DNA deamination (GO:0045006) | 3.21104705 |
| 103 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.20642317 |
| 104 | cell cycle G1/S phase transition (GO:0044843) | 3.20642317 |
| 105 | mitotic recombination (GO:0006312) | 3.19781210 |
| 106 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.18662075 |
| 107 | spindle assembly checkpoint (GO:0071173) | 3.18489189 |
| 108 | protein K6-linked ubiquitination (GO:0085020) | 3.17496472 |
| 109 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.17275954 |
| 110 | cytochrome complex assembly (GO:0017004) | 3.15904380 |
| 111 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.14844009 |
| 112 | regulation of mitotic spindle organization (GO:0060236) | 3.13858817 |
| 113 | protein localization to kinetochore (GO:0034501) | 3.13421283 |
| 114 | blastocyst development (GO:0001824) | 3.12515100 |
| 115 | DNA damage response, detection of DNA damage (GO:0042769) | 3.11684980 |
| 116 | histone mRNA metabolic process (GO:0008334) | 3.10395750 |
| 117 | positive regulation of viral transcription (GO:0050434) | 3.09767012 |
| 118 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.08767833 |
| 119 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.08767833 |
| 120 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.06404462 |
| 121 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.04917927 |
| 122 | regulation of mitochondrial translation (GO:0070129) | 3.03620346 |
| 123 | protein targeting to mitochondrion (GO:0006626) | 3.02985846 |
| 124 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.02840054 |
| 125 | regulation of chromosome segregation (GO:0051983) | 3.02609723 |
| 126 | translational termination (GO:0006415) | 3.01158736 |
| 127 | regulation of ligase activity (GO:0051340) | 3.01101602 |
| 128 | establishment of integrated proviral latency (GO:0075713) | 2.99043877 |
| 129 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.97941367 |
| 130 | tRNA processing (GO:0008033) | 2.96457961 |
| 131 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.94960146 |
| 132 | protein localization to mitochondrion (GO:0070585) | 2.92286801 |
| 133 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.91067881 |
| 134 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.88463902 |
| 135 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.88463902 |
| 136 | organelle disassembly (GO:1903008) | 2.88121389 |
| 137 | pseudouridine synthesis (GO:0001522) | 2.88021394 |
| 138 | establishment of protein localization to mitochondrion (GO:0072655) | 2.87569822 |
| 139 | inner mitochondrial membrane organization (GO:0007007) | 2.86952491 |
| 140 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.85705706 |
| 141 | respiratory electron transport chain (GO:0022904) | 2.85032133 |
| 142 | ubiquinone biosynthetic process (GO:0006744) | 2.83326905 |
| 143 | recombinational repair (GO:0000725) | 2.82458612 |
| 144 | electron transport chain (GO:0022900) | 2.81865546 |
| 145 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.81517888 |
| 146 | ubiquinone metabolic process (GO:0006743) | 2.81175626 |
| 147 | intraciliary transport (GO:0042073) | 2.80571663 |
| 148 | double-strand break repair via homologous recombination (GO:0000724) | 2.79103944 |
| 149 | protein-cofactor linkage (GO:0018065) | 2.78126657 |
| 150 | mitochondrial RNA metabolic process (GO:0000959) | 2.76818851 |
| 151 | tRNA metabolic process (GO:0006399) | 2.75570529 |
| 152 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.74159770 |
| 153 | intracellular protein transmembrane import (GO:0044743) | 2.74074442 |
| 154 | resolution of meiotic recombination intermediates (GO:0000712) | 2.73753999 |
| 155 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.72036810 |
| 156 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.72036810 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.13909027 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.70931886 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.09825194 |
| 4 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.02514253 |
| 5 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.88461683 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.78759696 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.59813609 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.48346557 |
| 9 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.45069877 |
| 10 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.40062154 |
| 11 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.32972552 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.17419557 |
| 13 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.08306506 |
| 14 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.95944278 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.84708436 |
| 16 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.83419974 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.80279946 |
| 18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.78371369 |
| 19 | * MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.69027650 |
| 20 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.60111743 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.58212416 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.55515760 |
| 23 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.44650948 |
| 24 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 2.35597564 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.35366920 |
| 26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.33435957 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.31488576 |
| 28 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.28561688 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.24481795 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.18532888 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.14084136 |
| 32 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.13634528 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.11480890 |
| 34 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.11384876 |
| 35 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.08102497 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.99992616 |
| 37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.99090551 |
| 38 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.98653594 |
| 39 | VDR_22108803_ChIP-Seq_LS180_Human | 1.97638995 |
| 40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.92298133 |
| 41 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.90769187 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87857630 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.87295176 |
| 44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.84812116 |
| 45 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.84245158 |
| 46 | EWS_26573619_Chip-Seq_HEK293_Human | 1.82301039 |
| 47 | FUS_26573619_Chip-Seq_HEK293_Human | 1.80783856 |
| 48 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.79662629 |
| 49 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.76238116 |
| 50 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.73400393 |
| 51 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.71474565 |
| 52 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.70677971 |
| 53 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.70403737 |
| 54 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.65244604 |
| 55 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.63849615 |
| 56 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.59945961 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58557737 |
| 58 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.56561931 |
| 59 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.52547076 |
| 60 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48833039 |
| 61 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.43758405 |
| 62 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.43277234 |
| 63 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.42768406 |
| 64 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.39593984 |
| 65 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.39046932 |
| 66 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.36689554 |
| 67 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.33127175 |
| 68 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.28617585 |
| 69 | P300_19829295_ChIP-Seq_ESCs_Human | 1.28135792 |
| 70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.25988772 |
| 71 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25054977 |
| 72 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.24861232 |
| 73 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.23967350 |
| 74 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.20442140 |
| 75 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.19913460 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.19587481 |
| 77 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.16244186 |
| 78 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.12457565 |
| 79 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10320256 |
| 80 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.09635401 |
| 81 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.09342099 |
| 82 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.07090128 |
| 83 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.06607354 |
| 84 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.06329630 |
| 85 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.05935151 |
| 86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05130091 |
| 87 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.04674084 |
| 88 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.03893428 |
| 89 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.02999446 |
| 90 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.02880820 |
| 91 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.01734288 |
| 92 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99197016 |
| 93 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.98696245 |
| 94 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97916708 |
| 95 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.97787870 |
| 96 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.97565711 |
| 97 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.96856334 |
| 98 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.96682745 |
| 99 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.96236855 |
| 100 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.96236855 |
| 101 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.95996718 |
| 102 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95932309 |
| 103 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.95142647 |
| 104 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.95142647 |
| 105 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.95142647 |
| 106 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.94172389 |
| 107 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.94039650 |
| 108 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.91998906 |
| 109 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91246543 |
| 110 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.90767483 |
| 111 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.90435350 |
| 112 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.89355535 |
| 113 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.89113044 |
| 114 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.88054224 |
| 115 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.87736389 |
| 116 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.86279828 |
| 117 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.85781957 |
| 118 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.85338691 |
| 119 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.84642808 |
| 120 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.83360854 |
| 121 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.83360854 |
| 122 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83270376 |
| 123 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.83014226 |
| 124 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.82596770 |
| 125 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.82596770 |
| 126 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.82381046 |
| 127 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82255121 |
| 128 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.82120289 |
| 129 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.82065377 |
| 130 | * KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.81477753 |
| 131 | NCOR_22424771_ChIP-Seq_293T_Human | 0.80795569 |
| 132 | AR_20517297_ChIP-Seq_VCAP_Human | 0.80583133 |
| 133 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80109419 |
| 134 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.79131415 |
| 135 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.78576199 |
| 136 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.78172515 |
| 137 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.77152575 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.63257600 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.23959654 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.19539968 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.10287853 |
| 5 | MP0008057_abnormal_DNA_replication | 4.01227584 |
| 6 | MP0003077_abnormal_cell_cycle | 3.77467130 |
| 7 | MP0008058_abnormal_DNA_repair | 3.58945148 |
| 8 | MP0003718_maternal_effect | 3.50462306 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.83636680 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.83506459 |
| 11 | MP0003786_premature_aging | 2.60470146 |
| 12 | MP0003123_paternal_imprinting | 2.57225203 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.52088049 |
| 14 | MP0003315_abnormal_perineum_morphology | 2.12813963 |
| 15 | MP0003787_abnormal_imprinting | 2.11943626 |
| 16 | MP0003136_yellow_coat_color | 2.05956026 |
| 17 | MP0001730_embryonic_growth_arrest | 1.89727955 |
| 18 | MP0006292_abnormal_olfactory_placode | 1.86628250 |
| 19 | MP0008260_abnormal_autophagy | 1.83300134 |
| 20 | MP0002837_dystrophic_cardiac_calcinosis | 1.78825237 |
| 21 | MP0006035_abnormal_mitochondrial_morpho | 1.76967029 |
| 22 | MP0000350_abnormal_cell_proliferation | 1.74036376 |
| 23 | MP0003880_abnormal_central_pattern | 1.65165975 |
| 24 | MP0002102_abnormal_ear_morphology | 1.59546787 |
| 25 | MP0009697_abnormal_copulation | 1.56002612 |
| 26 | MP0005379_endocrine/exocrine_gland_phen | 1.54986925 |
| 27 | MP0003121_genomic_imprinting | 1.54475476 |
| 28 | MP0005394_taste/olfaction_phenotype | 1.54167220 |
| 29 | MP0005499_abnormal_olfactory_system | 1.54167220 |
| 30 | MP0002210_abnormal_sex_determination | 1.54086850 |
| 31 | MP0003941_abnormal_skin_development | 1.49679533 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.47780549 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.46682847 |
| 34 | MP0001984_abnormal_olfaction | 1.40863372 |
| 35 | MP0001672_abnormal_embryogenesis/_devel | 1.40215980 |
| 36 | MP0005380_embryogenesis_phenotype | 1.40215980 |
| 37 | MP0004142_abnormal_muscle_tone | 1.39375202 |
| 38 | MP0002751_abnormal_autonomic_nervous | 1.38257446 |
| 39 | MP0001697_abnormal_embryo_size | 1.36623011 |
| 40 | MP0003567_abnormal_fetal_cardiomyocyte | 1.36072438 |
| 41 | MP0003806_abnormal_nucleotide_metabolis | 1.34778067 |
| 42 | MP0002234_abnormal_pharynx_morphology | 1.34026932 |
| 43 | MP0010307_abnormal_tumor_latency | 1.33052153 |
| 44 | MP0002736_abnormal_nociception_after | 1.32451162 |
| 45 | MP0009333_abnormal_splenocyte_physiolog | 1.31622704 |
| 46 | MP0000647_abnormal_sebaceous_gland | 1.29287513 |
| 47 | MP0010030_abnormal_orbit_morphology | 1.29105644 |
| 48 | MP0000631_abnormal_neuroendocrine_gland | 1.28475196 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.28164867 |
| 50 | MP0003950_abnormal_plasma_membrane | 1.26682328 |
| 51 | MP0009046_muscle_twitch | 1.26616327 |
| 52 | MP0002638_abnormal_pupillary_reflex | 1.25581564 |
| 53 | MP0003646_muscle_fatigue | 1.24886940 |
| 54 | MP0003937_abnormal_limbs/digits/tail_de | 1.24876024 |
| 55 | MP0005075_abnormal_melanosome_morpholog | 1.24020912 |
| 56 | MP0001145_abnormal_male_reproductive | 1.22835470 |
| 57 | MP0003186_abnormal_redox_activity | 1.21576346 |
| 58 | MP0000537_abnormal_urethra_morphology | 1.20516683 |
| 59 | MP0001119_abnormal_female_reproductive | 1.20227125 |
| 60 | MP0000653_abnormal_sex_gland | 1.19942358 |
| 61 | MP0001764_abnormal_homeostasis | 1.19083024 |
| 62 | MP0001929_abnormal_gametogenesis | 1.18816251 |
| 63 | MP0003122_maternal_imprinting | 1.18724772 |
| 64 | MP0002085_abnormal_embryonic_tissue | 1.17019638 |
| 65 | MP0001529_abnormal_vocalization | 1.16530495 |
| 66 | MP0002080_prenatal_lethality | 1.16457804 |
| 67 | MP0003984_embryonic_growth_retardation | 1.15341369 |
| 68 | MP0005645_abnormal_hypothalamus_physiol | 1.15234114 |
| 69 | MP0005551_abnormal_eye_electrophysiolog | 1.15197752 |
| 70 | MP0005187_abnormal_penis_morphology | 1.13880479 |
| 71 | MP0001293_anophthalmia | 1.13628770 |
| 72 | MP0000313_abnormal_cell_death | 1.11377830 |
| 73 | MP0002088_abnormal_embryonic_growth/wei | 1.10843575 |
| 74 | MP0002233_abnormal_nose_morphology | 1.08818063 |
| 75 | MP0003195_calcinosis | 1.06695426 |
| 76 | MP0002938_white_spotting | 1.04546537 |
| 77 | MP0000358_abnormal_cell_content/ | 1.03431172 |
| 78 | MP0005395_other_phenotype | 1.02904413 |
| 79 | MP0002163_abnormal_gland_morphology | 1.01679626 |
| 80 | MP0002277_abnormal_respiratory_mucosa | 0.99598312 |
| 81 | MP0005646_abnormal_pituitary_gland | 0.97877083 |
| 82 | MP0000049_abnormal_middle_ear | 0.97794806 |
| 83 | MP0001968_abnormal_touch/_nociception | 0.97181698 |
| 84 | MP0002396_abnormal_hematopoietic_system | 0.95856966 |
| 85 | MP0002019_abnormal_tumor_incidence | 0.95216598 |
| 86 | MP0005389_reproductive_system_phenotype | 0.94515571 |
| 87 | MP0005408_hypopigmentation | 0.93967598 |
| 88 | MP0003890_abnormal_embryonic-extraembry | 0.93504275 |
| 89 | MP0002084_abnormal_developmental_patter | 0.92353602 |
| 90 | MP0002095_abnormal_skin_pigmentation | 0.92245328 |
| 91 | MP0002160_abnormal_reproductive_system | 0.91998966 |
| 92 | MP0000427_abnormal_hair_cycle | 0.90772860 |
| 93 | MP0005171_absent_coat_pigmentation | 0.90564031 |
| 94 | MP0001542_abnormal_bone_strength | 0.90166971 |
| 95 | MP0008872_abnormal_physiological_respon | 0.89907735 |
| 96 | MP0002086_abnormal_extraembryonic_tissu | 0.89620626 |
| 97 | MP0003938_abnormal_ear_development | 0.89392991 |
| 98 | MP0003011_delayed_dark_adaptation | 0.89118201 |
| 99 | MP0001727_abnormal_embryo_implantation | 0.88656200 |
| 100 | MP0000516_abnormal_urinary_system | 0.88138795 |
| 101 | MP0005367_renal/urinary_system_phenotyp | 0.88138795 |
| 102 | MP0004215_abnormal_myocardial_fiber | 0.87262218 |
| 103 | MP0001286_abnormal_eye_development | 0.86529748 |
| 104 | MP0002132_abnormal_respiratory_system | 0.86481889 |
| 105 | MP0008875_abnormal_xenobiotic_pharmacok | 0.86191428 |
| 106 | MP0004147_increased_porphyrin_level | 0.84385071 |
| 107 | MP0001986_abnormal_taste_sensitivity | 0.82007533 |
| 108 | MP0000490_abnormal_crypts_of | 0.77467197 |
| 109 | MP0008995_early_reproductive_senescence | 0.76999867 |
| 110 | MP0001485_abnormal_pinna_reflex | 0.75608989 |
| 111 | MP0002090_abnormal_vision | 0.74915089 |
| 112 | MP0000372_irregular_coat_pigmentation | 0.74494276 |
| 113 | MP0004197_abnormal_fetal_growth/weight/ | 0.72122811 |
| 114 | MP0003755_abnormal_palate_morphology | 0.70670404 |
| 115 | MP0008789_abnormal_olfactory_epithelium | 0.70488630 |
| 116 | MP0005248_abnormal_Harderian_gland | 0.69504240 |
| 117 | MP0005195_abnormal_posterior_eye | 0.69273480 |
| 118 | MP0005451_abnormal_body_composition | 0.69246023 |
| 119 | MP0001661_extended_life_span | 0.68631363 |
| 120 | MP0006072_abnormal_retinal_apoptosis | 0.68391306 |
| 121 | MP0005410_abnormal_fertilization | 0.68299790 |
| 122 | MP0003119_abnormal_digestive_system | 0.67349649 |
| 123 | MP0002254_reproductive_system_inflammat | 0.67088990 |
| 124 | MP0004808_abnormal_hematopoietic_stem | 0.66475950 |
| 125 | MP0002653_abnormal_ependyma_morphology | 0.65447823 |
| 126 | MP0002752_abnormal_somatic_nervous | 0.65033856 |
| 127 | MP0005384_cellular_phenotype | 0.64947621 |
| 128 | MP0003699_abnormal_female_reproductive | 0.64227156 |
| 129 | MP0002282_abnormal_trachea_morphology | 0.63448415 |
| 130 | MP0003878_abnormal_ear_physiology | 0.63328537 |
| 131 | MP0005377_hearing/vestibular/ear_phenot | 0.63328537 |
| 132 | MP0002111_abnormal_tail_morphology | 0.62922836 |
| 133 | MP0002127_abnormal_cardiovascular_syste | 0.62744718 |
| 134 | MP0009053_abnormal_anal_canal | 0.61305885 |
| 135 | MP0002161_abnormal_fertility/fecundity | 0.61168041 |
| 136 | MP0005621_abnormal_cell_physiology | 0.59282701 |
| 137 | MP0001919_abnormal_reproductive_system | 0.57670767 |
| 138 | MP0005253_abnormal_eye_physiology | 0.57536328 |
| 139 | MP0005391_vision/eye_phenotype | 0.57236882 |
| 140 | MP0004133_heterotaxia | 0.57125724 |
| 141 | MP0001188_hyperpigmentation | 0.56337535 |
| 142 | MP0003698_abnormal_male_reproductive | 0.56066903 |
| 143 | MP0000858_altered_metastatic_potential | 0.55229703 |
| 144 | MP0000383_abnormal_hair_follicle | 0.55228918 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.84297087 |
| 2 | Breast hypoplasia (HP:0003187) | 4.61046070 |
| 3 | Carpal bone hypoplasia (HP:0001498) | 3.68782186 |
| 4 | Patellar aplasia (HP:0006443) | 3.57367190 |
| 5 | Reticulocytopenia (HP:0001896) | 3.50092373 |
| 6 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.37910436 |
| 7 | Abnormality of the anterior horn cell (HP:0006802) | 3.26816899 |
| 8 | Degeneration of anterior horn cells (HP:0002398) | 3.26816899 |
| 9 | Cerebral hypomyelination (HP:0006808) | 3.13888545 |
| 10 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.13817095 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.11418576 |
| 12 | Chromsome breakage (HP:0040012) | 3.08209840 |
| 13 | Molar tooth sign on MRI (HP:0002419) | 3.05116377 |
| 14 | Abnormality of midbrain morphology (HP:0002418) | 3.05116377 |
| 15 | Absent radius (HP:0003974) | 3.04415322 |
| 16 | Meckel diverticulum (HP:0002245) | 3.01353399 |
| 17 | Rough bone trabeculation (HP:0100670) | 2.94448408 |
| 18 | Abnormality of the labia minora (HP:0012880) | 2.90794143 |
| 19 | Absent forearm bone (HP:0003953) | 2.86445405 |
| 20 | Aplasia involving forearm bones (HP:0009822) | 2.86445405 |
| 21 | Medial flaring of the eyebrow (HP:0010747) | 2.82838488 |
| 22 | Impulsivity (HP:0100710) | 2.81079417 |
| 23 | Hepatic necrosis (HP:0002605) | 2.80535862 |
| 24 | Abnormality of the ileum (HP:0001549) | 2.80532020 |
| 25 | Supernumerary spleens (HP:0009799) | 2.78772409 |
| 26 | Methylmalonic acidemia (HP:0002912) | 2.78702035 |
| 27 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.77861870 |
| 28 | Abnormality of the preputium (HP:0100587) | 2.72570234 |
| 29 | Irregular epiphyses (HP:0010582) | 2.71114712 |
| 30 | Abnormality of glycolysis (HP:0004366) | 2.67608066 |
| 31 | Increased serum pyruvate (HP:0003542) | 2.67608066 |
| 32 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.66112060 |
| 33 | Abnormality of chromosome stability (HP:0003220) | 2.65744144 |
| 34 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.65201120 |
| 35 | Macrocytic anemia (HP:0001972) | 2.57919297 |
| 36 | Nephronophthisis (HP:0000090) | 2.53432991 |
| 37 | Abnormal number of erythroid precursors (HP:0012131) | 2.48589588 |
| 38 | Renal Fanconi syndrome (HP:0001994) | 2.47824792 |
| 39 | Duplicated collecting system (HP:0000081) | 2.47029702 |
| 40 | Flat capital femoral epiphysis (HP:0003370) | 2.46205109 |
| 41 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.45234100 |
| 42 | Cerebral edema (HP:0002181) | 2.43746385 |
| 43 | Congenital primary aphakia (HP:0007707) | 2.43433239 |
| 44 | Pancreatic cysts (HP:0001737) | 2.42878003 |
| 45 | Abnormal lung lobation (HP:0002101) | 2.42805221 |
| 46 | Acute necrotizing encephalopathy (HP:0006965) | 2.41324216 |
| 47 | Methylmalonic aciduria (HP:0012120) | 2.38835447 |
| 48 | 3-Methylglutaconic aciduria (HP:0003535) | 2.38495928 |
| 49 | Small intestinal stenosis (HP:0012848) | 2.36709327 |
| 50 | Duodenal stenosis (HP:0100867) | 2.36709327 |
| 51 | Nephrogenic diabetes insipidus (HP:0009806) | 2.36302408 |
| 52 | Horseshoe kidney (HP:0000085) | 2.35711090 |
| 53 | Type II lissencephaly (HP:0007260) | 2.34863254 |
| 54 | Gait imbalance (HP:0002141) | 2.34658132 |
| 55 | Ureteral duplication (HP:0000073) | 2.33234905 |
| 56 | Premature graying of hair (HP:0002216) | 2.32152354 |
| 57 | Abnormal trabecular bone morphology (HP:0100671) | 2.32081338 |
| 58 | Cleft eyelid (HP:0000625) | 2.31290063 |
| 59 | Abnormality of the renal cortex (HP:0011035) | 2.30810991 |
| 60 | Secondary amenorrhea (HP:0000869) | 2.29738469 |
| 61 | Hyperglycinemia (HP:0002154) | 2.27082574 |
| 62 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.25872145 |
| 63 | Lactic acidosis (HP:0003128) | 2.25731435 |
| 64 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.24696660 |
| 65 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.24696660 |
| 66 | Abnormal protein glycosylation (HP:0012346) | 2.24696660 |
| 67 | Abnormal glycosylation (HP:0012345) | 2.24696660 |
| 68 | Bile duct proliferation (HP:0001408) | 2.24391570 |
| 69 | Abnormal biliary tract physiology (HP:0012439) | 2.24391570 |
| 70 | Absent epiphyses (HP:0010577) | 2.24017984 |
| 71 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.24017984 |
| 72 | Oral leukoplakia (HP:0002745) | 2.22732591 |
| 73 | Adrenal hypoplasia (HP:0000835) | 2.22695917 |
| 74 | Pallor (HP:0000980) | 2.22020248 |
| 75 | Abnormal spermatogenesis (HP:0008669) | 2.21055706 |
| 76 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.20617564 |
| 77 | Pancreatic fibrosis (HP:0100732) | 2.19925611 |
| 78 | Aplastic anemia (HP:0001915) | 2.19742532 |
| 79 | Absent thumb (HP:0009777) | 2.19473642 |
| 80 | Abnormality of the renal medulla (HP:0100957) | 2.18966865 |
| 81 | Agnosia (HP:0010524) | 2.16483374 |
| 82 | Chronic hepatic failure (HP:0100626) | 2.16064605 |
| 83 | Type I transferrin isoform profile (HP:0003642) | 2.15696775 |
| 84 | Bone marrow hypocellularity (HP:0005528) | 2.13829820 |
| 85 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.13121961 |
| 86 | Spinal muscular atrophy (HP:0007269) | 2.12681740 |
| 87 | Congenital, generalized hypertrichosis (HP:0004540) | 2.10087390 |
| 88 | Increased hepatocellular lipid droplets (HP:0006565) | 2.09734437 |
| 89 | Poor head control (HP:0002421) | 2.07675012 |
| 90 | Optic disc pallor (HP:0000543) | 2.06854326 |
| 91 | Sloping forehead (HP:0000340) | 2.05422608 |
| 92 | Triphalangeal thumb (HP:0001199) | 2.05418561 |
| 93 | Premature ovarian failure (HP:0008209) | 2.05250960 |
| 94 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.04720563 |
| 95 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.04720563 |
| 96 | Abnormality of the renal collecting system (HP:0004742) | 2.02322306 |
| 97 | Myelodysplasia (HP:0002863) | 2.01833526 |
| 98 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.00725582 |
| 99 | Mitochondrial inheritance (HP:0001427) | 1.99475407 |
| 100 | Postaxial foot polydactyly (HP:0001830) | 1.99469887 |
| 101 | Sclerocornea (HP:0000647) | 1.99435492 |
| 102 | Genital tract atresia (HP:0001827) | 1.99325094 |
| 103 | Increased intramyocellular lipid droplets (HP:0012240) | 1.98316179 |
| 104 | Breast aplasia (HP:0100783) | 1.97884921 |
| 105 | Respiratory failure (HP:0002878) | 1.94876204 |
| 106 | True hermaphroditism (HP:0010459) | 1.94813305 |
| 107 | Stenosis of the external auditory canal (HP:0000402) | 1.94552927 |
| 108 | Abnormality of the pons (HP:0007361) | 1.93706779 |
| 109 | Intestinal atresia (HP:0011100) | 1.93370699 |
| 110 | Median cleft lip (HP:0000161) | 1.93345696 |
| 111 | Vaginal atresia (HP:0000148) | 1.93115851 |
| 112 | Abnormality of the duodenum (HP:0002246) | 1.92567262 |
| 113 | Lethargy (HP:0001254) | 1.92065656 |
| 114 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.92056979 |
| 115 | 11 pairs of ribs (HP:0000878) | 1.91940047 |
| 116 | Short tibia (HP:0005736) | 1.91388311 |
| 117 | Increased CSF lactate (HP:0002490) | 1.91200495 |
| 118 | Microretrognathia (HP:0000308) | 1.89523214 |
| 119 | Multiple enchondromatosis (HP:0005701) | 1.89445905 |
| 120 | Exertional dyspnea (HP:0002875) | 1.89111784 |
| 121 | Sparse lateral eyebrow (HP:0005338) | 1.88387940 |
| 122 | Small epiphyses (HP:0010585) | 1.86619992 |
| 123 | Progressive macrocephaly (HP:0004481) | 1.85995429 |
| 124 | Congenital stationary night blindness (HP:0007642) | 1.85302487 |
| 125 | Hypothermia (HP:0002045) | 1.84394666 |
| 126 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.84372728 |
| 127 | Lissencephaly (HP:0001339) | 1.84268625 |
| 128 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.84080263 |
| 129 | Preaxial hand polydactyly (HP:0001177) | 1.84054624 |
| 130 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.83562186 |
| 131 | Progressive inability to walk (HP:0002505) | 1.82150306 |
| 132 | Postaxial hand polydactyly (HP:0001162) | 1.82020851 |
| 133 | Microvesicular hepatic steatosis (HP:0001414) | 1.81835486 |
| 134 | Anencephaly (HP:0002323) | 1.81427919 |
| 135 | Colon cancer (HP:0003003) | 1.81365028 |
| 136 | Dandy-Walker malformation (HP:0001305) | 1.80625337 |
| 137 | Abnormality of the umbilical cord (HP:0010881) | 1.79460226 |
| 138 | Renal cortical cysts (HP:0000803) | 1.78415084 |
| 139 | Short middle phalanx of the 5th finger (HP:0004220) | 1.78304223 |
| 140 | Hypoplasia of the uterus (HP:0000013) | 1.78199920 |
| 141 | Embryonal renal neoplasm (HP:0011794) | 1.78151308 |
| 142 | Sparse eyelashes (HP:0000653) | 1.77930210 |
| 143 | Reduced antithrombin III activity (HP:0001976) | 1.77682716 |
| 144 | Acute encephalopathy (HP:0006846) | 1.76951978 |
| 145 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.76869368 |
| 146 | Abnormality of methionine metabolism (HP:0010901) | 1.76617728 |
| 147 | Exercise intolerance (HP:0003546) | 1.76589656 |
| 148 | Increased serum lactate (HP:0002151) | 1.75974730 |
| 149 | Hypoplasia of the pons (HP:0012110) | 1.75789822 |
| 150 | Abnormality of the metopic suture (HP:0005556) | 1.75717306 |
| 151 | CNS demyelination (HP:0007305) | 1.74862835 |
| 152 | Poor coordination (HP:0002370) | 1.74101876 |
| 153 | Cellular immunodeficiency (HP:0005374) | 1.73990135 |
| 154 | Bifid tongue (HP:0010297) | 1.72986464 |
| 155 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.71297992 |
| 156 | CNS hypomyelination (HP:0003429) | 1.69684522 |
| 157 | Capillary hemangiomas (HP:0005306) | 1.69632874 |
| 158 | Prolonged neonatal jaundice (HP:0006579) | 1.69300121 |
| 159 | Selective tooth agenesis (HP:0001592) | 1.69059791 |
| 160 | Ectopic kidney (HP:0000086) | 1.69041215 |
| 161 | Lipid accumulation in hepatocytes (HP:0006561) | 1.68313580 |
| 162 | Slender long bone (HP:0003100) | 1.67893714 |
| 163 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.66749487 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.07711720 |
| 2 | WEE1 | 3.82691876 |
| 3 | EIF2AK1 | 3.80448475 |
| 4 | PLK4 | 3.01648444 |
| 5 | MAP4K2 | 2.97716657 |
| 6 | STK16 | 2.84643294 |
| 7 | BRSK2 | 2.84378108 |
| 8 | SRPK1 | 2.76776102 |
| 9 | NME2 | 2.64267593 |
| 10 | PBK | 2.44380038 |
| 11 | VRK2 | 2.41426734 |
| 12 | CCNB1 | 2.27790058 |
| 13 | ACVR1B | 2.22766820 |
| 14 | EIF2AK3 | 2.22739909 |
| 15 | TRIM28 | 2.18786640 |
| 16 | CDC7 | 2.11408626 |
| 17 | VRK1 | 2.11054474 |
| 18 | PLK3 | 2.01986051 |
| 19 | TSSK6 | 1.96428528 |
| 20 | MKNK1 | 1.89464410 |
| 21 | PLK1 | 1.87694155 |
| 22 | ARAF | 1.86042988 |
| 23 | BRAF | 1.81020307 |
| 24 | MKNK2 | 1.80852886 |
| 25 | CDK19 | 1.80806421 |
| 26 | TTK | 1.80015862 |
| 27 | NEK2 | 1.76983259 |
| 28 | AKT3 | 1.72008947 |
| 29 | MAP3K4 | 1.67905505 |
| 30 | FRK | 1.59855778 |
| 31 | MST4 | 1.56256880 |
| 32 | MAP2K7 | 1.54238372 |
| 33 | PINK1 | 1.51595267 |
| 34 | PIM2 | 1.50643722 |
| 35 | ZAK | 1.50436105 |
| 36 | BRSK1 | 1.44728684 |
| 37 | STK38L | 1.44269940 |
| 38 | DYRK3 | 1.42107062 |
| 39 | BCKDK | 1.41504943 |
| 40 | AURKB | 1.33213157 |
| 41 | EIF2AK2 | 1.29267925 |
| 42 | CASK | 1.27398195 |
| 43 | ADRBK2 | 1.23336450 |
| 44 | MAP3K12 | 1.23230022 |
| 45 | CSNK1G2 | 1.22442999 |
| 46 | EPHA2 | 1.19721151 |
| 47 | CHEK2 | 1.15013995 |
| 48 | TNIK | 1.14113804 |
| 49 | TESK2 | 1.13760762 |
| 50 | NEK1 | 1.13053048 |
| 51 | ATR | 1.08812374 |
| 52 | AURKA | 1.05878865 |
| 53 | CDK7 | 1.05706500 |
| 54 | OXSR1 | 0.99653726 |
| 55 | GRK1 | 0.99438165 |
| 56 | STK3 | 0.97588285 |
| 57 | DYRK2 | 0.96733593 |
| 58 | RPS6KA4 | 0.96267651 |
| 59 | PNCK | 0.94700771 |
| 60 | PASK | 0.94596037 |
| 61 | TLK1 | 0.92257820 |
| 62 | MAPK13 | 0.88921032 |
| 63 | BCR | 0.88433924 |
| 64 | CDK8 | 0.83836987 |
| 65 | MAP3K3 | 0.82562336 |
| 66 | CHEK1 | 0.79237903 |
| 67 | WNK3 | 0.78643832 |
| 68 | STK4 | 0.78064506 |
| 69 | NME1 | 0.77698519 |
| 70 | BMPR1B | 0.76955095 |
| 71 | NUAK1 | 0.76351485 |
| 72 | TAF1 | 0.72553227 |
| 73 | BMPR2 | 0.72520010 |
| 74 | CSNK2A1 | 0.69949747 |
| 75 | MAP3K8 | 0.69858056 |
| 76 | STK39 | 0.65830942 |
| 77 | RPS6KB2 | 0.65336390 |
| 78 | YES1 | 0.65011394 |
| 79 | STK24 | 0.64345654 |
| 80 | TGFBR1 | 0.63390878 |
| 81 | TAOK3 | 0.61110878 |
| 82 | INSRR | 0.59895347 |
| 83 | NEK6 | 0.59764068 |
| 84 | ERBB3 | 0.57989012 |
| 85 | WNK4 | 0.56499633 |
| 86 | ABL2 | 0.56271711 |
| 87 | CDK3 | 0.55672027 |
| 88 | ATM | 0.55668777 |
| 89 | PAK1 | 0.54906862 |
| 90 | CSNK2A2 | 0.54181118 |
| 91 | PRKCI | 0.53937321 |
| 92 | PLK2 | 0.53275366 |
| 93 | RPS6KA5 | 0.52033054 |
| 94 | PIM1 | 0.51358883 |
| 95 | MELK | 0.51086108 |
| 96 | GRK7 | 0.51040966 |
| 97 | CDK1 | 0.48810650 |
| 98 | MARK3 | 0.48046780 |
| 99 | CDK2 | 0.48026997 |
| 100 | LIMK1 | 0.48018184 |
| 101 | STK10 | 0.45952073 |
| 102 | PRKCE | 0.42418029 |
| 103 | CSNK1G3 | 0.40810827 |
| 104 | IKBKB | 0.40665878 |
| 105 | PRKCG | 0.37459862 |
| 106 | ERBB4 | 0.37279638 |
| 107 | EPHA4 | 0.36708140 |
| 108 | OBSCN | 0.36103190 |
| 109 | CSNK1A1 | 0.35757790 |
| 110 | PAK3 | 0.35738355 |
| 111 | NEK9 | 0.35155811 |
| 112 | IRAK1 | 0.34771743 |
| 113 | CAMKK2 | 0.34763923 |
| 114 | MAP3K5 | 0.32159328 |
| 115 | TXK | 0.32118514 |
| 116 | CDK4 | 0.30369144 |
| 117 | LATS2 | 0.27765193 |
| 118 | RAF1 | 0.27112464 |
| 119 | BRD4 | 0.26869437 |
| 120 | PIK3CG | 0.26021905 |
| 121 | TAOK2 | 0.25641044 |
| 122 | CLK1 | 0.24652385 |
| 123 | PDK3 | 0.23776438 |
| 124 | PDK4 | 0.23776438 |
| 125 | CSNK1G1 | 0.23574247 |
| 126 | CSNK1D | 0.22584128 |
| 127 | MAPKAPK5 | 0.22526567 |
| 128 | PDK2 | 0.22301708 |
| 129 | MOS | 0.22290808 |
| 130 | PRKACB | 0.22275551 |
| 131 | ADRBK1 | 0.22203895 |
| 132 | IRAK4 | 0.21603480 |
| 133 | CSNK1E | 0.19265231 |
| 134 | MYLK | 0.18286771 |
| 135 | CSNK1A1L | 0.17860573 |
| 136 | TIE1 | 0.17841032 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RNA polymerase_Homo sapiens_hsa03020 | 4.54658808 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.47635362 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.85021236 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.50789248 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.44761709 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.19743725 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.96502017 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.90079004 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.84137365 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.71381498 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 2.71307788 |
| 12 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.68686200 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.66486637 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 2.54479913 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 2.45210563 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.12720542 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.86386946 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.84516336 |
| 19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.84307964 |
| 20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.76456521 |
| 21 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.74559373 |
| 22 | Purine metabolism_Homo sapiens_hsa00230 | 1.66969903 |
| 23 | Protein export_Homo sapiens_hsa03060 | 1.63200826 |
| 24 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.56055956 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.49104447 |
| 26 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.37966129 |
| 27 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.36040089 |
| 28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.33776138 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.28921204 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.27542151 |
| 31 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.25646147 |
| 32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.21822188 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.19811523 |
| 34 | Parkinsons disease_Homo sapiens_hsa05012 | 1.16417294 |
| 35 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.14451732 |
| 36 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.11253136 |
| 37 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.04254943 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.02531035 |
| 39 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.00717339 |
| 40 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.99020160 |
| 41 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.97401305 |
| 42 | Peroxisome_Homo sapiens_hsa04146 | 0.96798391 |
| 43 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.96098225 |
| 44 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.93130082 |
| 45 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.84154099 |
| 46 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.81322716 |
| 47 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.78743736 |
| 48 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.78457946 |
| 49 | Legionellosis_Homo sapiens_hsa05134 | 0.72933115 |
| 50 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.70447997 |
| 51 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.68929074 |
| 52 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.68356177 |
| 53 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.67268318 |
| 54 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.65957642 |
| 55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.64755607 |
| 56 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.60925386 |
| 57 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.59178214 |
| 58 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58601480 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.58319012 |
| 60 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.56897364 |
| 61 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.56513535 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.56289138 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56273263 |
| 64 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.56181732 |
| 65 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.56081064 |
| 66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.56054684 |
| 67 | Alzheimers disease_Homo sapiens_hsa05010 | 0.55635588 |
| 68 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.54504038 |
| 69 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.54183179 |
| 70 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.53543862 |
| 71 | Allograft rejection_Homo sapiens_hsa05330 | 0.52043402 |
| 72 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.50545424 |
| 73 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.47816979 |
| 74 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.46796710 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45373219 |
| 76 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.43852486 |
| 77 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.43653420 |
| 78 | Olfactory transduction_Homo sapiens_hsa04740 | 0.40900584 |
| 79 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.40307943 |
| 80 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.40076772 |
| 81 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.40044216 |
| 82 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.38053922 |
| 83 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37015271 |
| 84 | Phagosome_Homo sapiens_hsa04145 | 0.36985492 |
| 85 | Metabolic pathways_Homo sapiens_hsa01100 | 0.36798633 |
| 86 | HTLV-I infection_Homo sapiens_hsa05166 | 0.36773795 |
| 87 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.34367142 |
| 88 | Nicotine addiction_Homo sapiens_hsa05033 | 0.33129000 |
| 89 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33000042 |
| 90 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.32601162 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.32036332 |
| 92 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.31994942 |
| 93 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.31670581 |
| 94 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31599758 |
| 95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.31130933 |
| 96 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.31039334 |
| 97 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.30851306 |
| 98 | Apoptosis_Homo sapiens_hsa04210 | 0.30704075 |
| 99 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.30135459 |
| 100 | Asthma_Homo sapiens_hsa05310 | 0.29830079 |
| 101 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.28032760 |
| 102 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.25983755 |
| 103 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25804481 |
| 104 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.25501101 |
| 105 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.25346595 |
| 106 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.25043421 |
| 107 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.24864791 |
| 108 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.24709557 |
| 109 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.22610854 |
| 110 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.22078065 |
| 111 | Alcoholism_Homo sapiens_hsa05034 | 0.22069399 |
| 112 | Measles_Homo sapiens_hsa05162 | 0.21876239 |
| 113 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21679136 |
| 114 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.21349570 |
| 115 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.21330229 |
| 116 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.21195328 |
| 117 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21090636 |
| 118 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.20454914 |
| 119 | Thyroid cancer_Homo sapiens_hsa05216 | 0.20187446 |
| 120 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.19277782 |
| 121 | Influenza A_Homo sapiens_hsa05164 | 0.18920063 |
| 122 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.18192777 |
| 123 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.17637184 |
| 124 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.17327258 |
| 125 | Malaria_Homo sapiens_hsa05144 | 0.16689839 |
| 126 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.16179094 |
| 127 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.15277196 |
| 128 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.14208846 |
| 129 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.13598774 |
| 130 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.13503956 |
| 131 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.12835015 |
| 132 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.12362042 |
| 133 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.11224626 |
| 134 | Shigellosis_Homo sapiens_hsa05131 | 0.10702560 |
| 135 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.10547686 |
| 136 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.10493599 |
| 137 | Hepatitis B_Homo sapiens_hsa05161 | 0.10470153 |
| 138 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.07446393 |
| 139 | Circadian rhythm_Homo sapiens_hsa04710 | 0.07135515 |

