MED8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.35411898
2ribosomal small subunit assembly (GO:0000028)5.28534925
3maturation of SSU-rRNA (GO:0030490)5.07542773
4viral transcription (GO:0019083)4.94952994
5ribosomal small subunit biogenesis (GO:0042274)4.93334852
6translational termination (GO:0006415)4.84956050
7regulation of RIG-I signaling pathway (GO:0039535)4.83032196
8ribosomal large subunit biogenesis (GO:0042273)4.81366576
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.52839149
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.38866833
11rRNA methylation (GO:0031167)4.37190978
12translational elongation (GO:0006414)4.33551807
13cotranslational protein targeting to membrane (GO:0006613)4.33237684
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.29175989
15protein targeting to ER (GO:0045047)4.28640766
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.20399587
17regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.19179102
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.13591001
19translational initiation (GO:0006413)4.12647151
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.12365870
21negative regulation of ligase activity (GO:0051352)4.10528088
22negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.10528088
23DNA strand elongation involved in DNA replication (GO:0006271)4.08938798
24protein localization to endoplasmic reticulum (GO:0070972)4.07964867
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05126116
26regulation of cellular amino acid metabolic process (GO:0006521)4.04321436
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.03674013
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.03674013
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.02620545
30telomere maintenance via semi-conservative replication (GO:0032201)4.01986358
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.00604154
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.00604154
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.00604154
34positive regulation of hormone biosynthetic process (GO:0046886)4.00235464
35DNA deamination (GO:0045006)3.96355585
36formation of translation preinitiation complex (GO:0001731)3.96207853
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.90694039
38termination of RNA polymerase III transcription (GO:0006386)3.90694039
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.90405762
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.90405762
41viral life cycle (GO:0019058)3.88877862
42cellular protein complex disassembly (GO:0043624)3.87763257
43translation (GO:0006412)3.87657741
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.87050209
45DNA strand elongation (GO:0022616)3.85213296
46antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.85148620
47regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.83991511
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78988634
49ribonucleoprotein complex biogenesis (GO:0022613)3.78611695
50mRNA cleavage (GO:0006379)3.74538271
51cullin deneddylation (GO:0010388)3.71753557
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.70902753
53ribosome assembly (GO:0042255)3.70497425
547-methylguanosine mRNA capping (GO:0006370)3.69366267
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66093644
56protein deneddylation (GO:0000338)3.66029466
57telomere maintenance via recombination (GO:0000722)3.59057140
587-methylguanosine RNA capping (GO:0009452)3.58657038
59RNA capping (GO:0036260)3.58657038
60positive regulation of ligase activity (GO:0051351)3.54977440
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54858622
62purine nucleobase biosynthetic process (GO:0009113)3.52770148
63spliceosomal snRNP assembly (GO:0000387)3.49392397
64pteridine-containing compound biosynthetic process (GO:0042559)3.49359678
65DNA replication checkpoint (GO:0000076)3.48133622
66nucleobase biosynthetic process (GO:0046112)3.46354945
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44880871
68ATP synthesis coupled proton transport (GO:0015986)3.44880871
69protein complex biogenesis (GO:0070271)3.43233761
70transcription-coupled nucleotide-excision repair (GO:0006283)3.42158929
71rRNA processing (GO:0006364)3.40906234
72COPI coating of Golgi vesicle (GO:0048205)3.40711670
73Golgi transport vesicle coating (GO:0048200)3.40711670
74positive regulation of protein sumoylation (GO:0033235)3.40425026
75DNA replication initiation (GO:0006270)3.36902290
76protein complex disassembly (GO:0043241)3.33809182
77positive regulation of cell cycle arrest (GO:0071158)3.31192227
78cellular component biogenesis (GO:0044085)3.26556798
79folic acid-containing compound biosynthetic process (GO:0009396)3.26230698
80mitotic recombination (GO:0006312)3.25401355
81rRNA metabolic process (GO:0016072)3.25204144
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.25024536
83mitochondrial respiratory chain complex assembly (GO:0033108)3.24154337
84maturation of 5.8S rRNA (GO:0000460)3.23592894
85CENP-A containing nucleosome assembly (GO:0034080)3.23514744
86regulation of ubiquitin-protein transferase activity (GO:0051438)3.23233577
87tRNA aminoacylation for protein translation (GO:0006418)3.23085332
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21430880
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.21430880
90NADH dehydrogenase complex assembly (GO:0010257)3.21430880
91respiratory electron transport chain (GO:0022904)3.21380401
92protein neddylation (GO:0045116)3.21167677
93macromolecular complex disassembly (GO:0032984)3.21023502
94regulation of mitochondrial translation (GO:0070129)3.19246167
95rRNA modification (GO:0000154)3.19124219
96tRNA aminoacylation (GO:0043039)3.17415379
97amino acid activation (GO:0043038)3.17415379
98G1/S transition of mitotic cell cycle (GO:0000082)3.16073564
99cell cycle G1/S phase transition (GO:0044843)3.16073564
100protein localization to mitochondrion (GO:0070585)3.15515760
101transcription elongation from RNA polymerase I promoter (GO:0006362)3.15300361
102termination of RNA polymerase I transcription (GO:0006363)3.14660916
103establishment of protein localization to mitochondrion (GO:0072655)3.14205055
104nucleotide-excision repair, DNA gap filling (GO:0006297)3.13100504
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12912509
106chromatin remodeling at centromere (GO:0031055)3.12582631
107regulation of ligase activity (GO:0051340)3.11960631
108antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.11943500
109electron transport chain (GO:0022900)3.11663519
110GDP-mannose metabolic process (GO:0019673)3.10426717
111pseudouridine synthesis (GO:0001522)3.08646353
112establishment of protein localization to mitochondrial membrane (GO:0090151)3.07751364
113protein maturation by protein folding (GO:0022417)3.05582578
114spliceosomal complex assembly (GO:0000245)3.04677800
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04489056
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04489056
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04338789
118telomere maintenance via telomere lengthening (GO:0010833)3.04072964
119ribosome biogenesis (GO:0042254)3.03278878
120deoxyribonucleotide biosynthetic process (GO:0009263)3.00109742
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99723868
122mitotic metaphase plate congression (GO:0007080)2.99413081
123nuclear-transcribed mRNA catabolic process (GO:0000956)2.99304690
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99177629
125DNA damage response, detection of DNA damage (GO:0042769)2.98285805
126transcription from RNA polymerase I promoter (GO:0006360)2.96704108
127protein targeting to mitochondrion (GO:0006626)2.96156458
128regulation of protein sumoylation (GO:0033233)2.95316642
129positive regulation of glycolytic process (GO:0045821)2.95060634
130nucleobase-containing small molecule interconversion (GO:0015949)2.94122774
131chaperone-mediated protein transport (GO:0072321)2.92295738
132positive regulation of fibroblast migration (GO:0010763)2.91887814
133regulation of translational termination (GO:0006449)2.89627684
134respiratory chain complex IV assembly (GO:0008535)2.88679277
135COPII vesicle coating (GO:0048208)2.88100482
136positive regulation of hormone metabolic process (GO:0032352)2.81125744
137regulation of cellular amine metabolic process (GO:0033238)2.77350696
138regulation of translation in response to stress (GO:0043555)2.77097180
139GMP metabolic process (GO:0046037)2.76137331
140oxidative phosphorylation (GO:0006119)2.72839042
141tetrahydrofolate metabolic process (GO:0046653)2.71873855
142AMP metabolic process (GO:0046033)2.71187340
143deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69584457
144cellular response to nicotine (GO:0071316)2.68533687
145cellular response to arsenic-containing substance (GO:0071243)2.68396665
146guanosine-containing compound biosynthetic process (GO:1901070)2.64723729
147histone mRNA metabolic process (GO:0008334)2.63343407
148peptidyl-histidine modification (GO:0018202)2.61691194
149response to testosterone (GO:0033574)2.61208521
150dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.61012536
151C-terminal protein lipidation (GO:0006501)2.60413057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74084214
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51209103
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.25699334
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.02161964
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.81491681
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77045413
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72151147
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.39905127
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37130192
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35811736
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04282470
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83986952
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81467792
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78492197
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78312242
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76977343
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74114384
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70356903
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66321058
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57998942
21VDR_23849224_ChIP-Seq_CD4+_Human2.56996794
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56829902
23XRN2_22483619_ChIP-Seq_HELA_Human2.56047874
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53092462
25DCP1A_22483619_ChIP-Seq_HELA_Human2.48306854
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47966084
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33084735
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28835382
29FOXP3_21729870_ChIP-Seq_TREG_Human2.19462356
30ELK1_19687146_ChIP-ChIP_HELA_Human2.11403893
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.08071840
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05471129
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.03155079
34* TTF2_22483619_ChIP-Seq_HELA_Human2.02941982
35* GABP_19822575_ChIP-Seq_HepG2_Human2.01261062
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92571199
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92371019
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.88113730
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84702590
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77277171
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74149806
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73389254
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72270978
44AR_21909140_ChIP-Seq_LNCAP_Human1.64874007
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61109460
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60475948
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59457883
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.58590479
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58529410
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54972912
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50600169
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49266465
53* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43773812
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40198431
55* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39170842
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38998646
57* ELK1_22589737_ChIP-Seq_MCF10A_Human1.38663454
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38584194
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38146796
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37977148
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33624269
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.31962434
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28539930
64KDM5A_27292631_Chip-Seq_BREAST_Human1.27554560
65MYC_18940864_ChIP-ChIP_HL60_Human1.25454355
66* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24989034
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24401654
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23629129
69CIITA_25753668_ChIP-Seq_RAJI_Human1.22512797
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21659252
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20271004
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19030058
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17090960
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14507613
75* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13684532
76* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08612176
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04217223
78TFEB_21752829_ChIP-Seq_HELA_Human1.03730929
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02729132
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00147277
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99536069
82* SPI1_23547873_ChIP-Seq_NB4_Human0.98472587
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98126737
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.98020588
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97391395
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.96850963
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96717379
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96677255
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95997039
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95228348
91ZNF263_19887448_ChIP-Seq_K562_Human0.95083082
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92348742
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92080239
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.91923362
95IRF1_19129219_ChIP-ChIP_H3396_Human0.89545117
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88687436
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86993283
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.86577519
99ELF5_23300383_ChIP-Seq_T47D_Human0.83815138
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83497365
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82363949
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81315521
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80305758
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78383293
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77338403
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77292447
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77091944
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75116996
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73680109
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72575390
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72373768
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71575023
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71347226
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68905958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53236953
2MP0004957_abnormal_blastocyst_morpholog3.93628853
3MP0010094_abnormal_chromosome_stability3.44459926
4MP0003077_abnormal_cell_cycle3.29722185
5MP0009379_abnormal_foot_pigmentation3.27644154
6MP0003111_abnormal_nucleus_morphology3.19156491
7MP0008058_abnormal_DNA_repair3.17429891
8MP0003806_abnormal_nucleotide_metabolis3.14520241
9MP0008932_abnormal_embryonic_tissue2.77088993
10MP0008057_abnormal_DNA_replication2.69542179
11MP0003950_abnormal_plasma_membrane2.58497019
12MP0003186_abnormal_redox_activity2.48697540
13MP0003718_maternal_effect2.40053606
14MP0005410_abnormal_fertilization2.28854769
15MP0003786_premature_aging2.16782864
16MP0003123_paternal_imprinting2.07986725
17MP0009697_abnormal_copulation2.06303198
18MP0009333_abnormal_splenocyte_physiolog2.01818261
19MP0008007_abnormal_cellular_replicative2.00957799
20MP0003315_abnormal_perineum_morphology1.92816264
21MP0000343_altered_response_to1.84614399
22MP0008438_abnormal_cutaneous_collagen1.81075370
23MP0005332_abnormal_amino_acid1.80502942
24MP0001764_abnormal_homeostasis1.77896570
25MP0002132_abnormal_respiratory_system1.76060018
26MP0002796_impaired_skin_barrier1.75160416
27MP0005058_abnormal_lysosome_morphology1.74232914
28MP0001730_embryonic_growth_arrest1.71290488
29MP0001881_abnormal_mammary_gland1.67182368
30MP0001835_abnormal_antigen_presentation1.66519846
31MP0010386_abnormal_urinary_bladder1.53829222
32MP0003303_peritoneal_inflammation1.50784373
33MP0006036_abnormal_mitochondrial_physio1.49790988
34MP0005408_hypopigmentation1.44831920
35MP0005083_abnormal_biliary_tract1.39924323
36MP0006082_CNS_inflammation1.39252869
37MP0010234_abnormal_vibrissa_follicle1.39176540
38MP0002148_abnormal_hypersensitivity_rea1.38999949
39MP0009785_altered_susceptibility_to1.37141314
40MP0000749_muscle_degeneration1.36543251
41MP0000313_abnormal_cell_death1.34874295
42MP0006035_abnormal_mitochondrial_morpho1.33774637
43MP0000350_abnormal_cell_proliferation1.32631492
44MP0003436_decreased_susceptibility_to1.32021311
45MP0003191_abnormal_cellular_cholesterol1.31916177
46MP0008260_abnormal_autophagy1.28752643
47MP0008995_early_reproductive_senescence1.26768976
48MP0002396_abnormal_hematopoietic_system1.23774575
49MP0000490_abnormal_crypts_of1.23327245
50MP0005501_abnormal_skin_physiology1.22329822
51MP0002837_dystrophic_cardiac_calcinosis1.19497186
52MP0001853_heart_inflammation1.19432250
53MP0005451_abnormal_body_composition1.18497007
54MP0002019_abnormal_tumor_incidence1.18440907
55MP0001727_abnormal_embryo_implantation1.16132418
56MP0000372_irregular_coat_pigmentation1.15762189
57MP0001243_abnormal_dermal_layer1.15408392
58MP0004782_abnormal_surfactant_physiolog1.14802958
59MP0005360_urolithiasis1.14153084
60MP0003656_abnormal_erythrocyte_physiolo1.13532128
61MP0002938_white_spotting1.13476569
62MP0008877_abnormal_DNA_methylation1.11110662
63MP0005025_abnormal_response_to1.10425489
64MP0005319_abnormal_enzyme/_coenzyme1.09950679
65MP0001661_extended_life_span1.09389866
66MP0000609_abnormal_liver_physiology1.09223489
67MP0001529_abnormal_vocalization1.08691867
68MP0002139_abnormal_hepatobiliary_system1.08511781
69MP0005085_abnormal_gallbladder_physiolo1.07594278
70MP0001697_abnormal_embryo_size1.07190867
71MP0010307_abnormal_tumor_latency1.06830905
72MP0002163_abnormal_gland_morphology1.06196189
73MP0003195_calcinosis1.04827675
74MP0003453_abnormal_keratinocyte_physiol1.04813168
75MP0005075_abnormal_melanosome_morpholog1.04715770
76MP0005379_endocrine/exocrine_gland_phen1.03618597
77MP0000015_abnormal_ear_pigmentation1.02888647
78MP0002398_abnormal_bone_marrow1.02434382
79MP0002080_prenatal_lethality1.02381803
80MP0005395_other_phenotype1.02167443
81MP0000689_abnormal_spleen_morphology1.02129500
82MP0003763_abnormal_thymus_physiology1.01785283
83MP0010030_abnormal_orbit_morphology1.00073912
84MP0002090_abnormal_vision0.99673920
85MP0005671_abnormal_response_to0.99619165
86MP0002429_abnormal_blood_cell0.99588339
87MP0003011_delayed_dark_adaptation0.99389053
88MP0005000_abnormal_immune_tolerance0.99335858
89MP0000358_abnormal_cell_content/0.98871393
90MP0001800_abnormal_humoral_immune0.98540718
91MP0006276_abnormal_autonomic_nervous0.97544612
92MP0000685_abnormal_immune_system0.97160810
93MP0003221_abnormal_cardiomyocyte_apopto0.96700250
94MP0004147_increased_porphyrin_level0.96490027
95MP0002452_abnormal_antigen_presenting0.96487284
96MP0002722_abnormal_immune_system0.95664693
97MP0002210_abnormal_sex_determination0.95059089
98MP0001790_abnormal_immune_system0.94374932
99MP0005387_immune_system_phenotype0.94374932
100MP0002723_abnormal_immune_serum0.93988938
101MP0005084_abnormal_gallbladder_morpholo0.92511688
102MP0008875_abnormal_xenobiotic_pharmacok0.92107643
103MP0001819_abnormal_immune_cell0.91307119
104MP0002420_abnormal_adaptive_immunity0.91207979
105MP0002138_abnormal_hepatobiliary_system0.89957138
106MP0003567_abnormal_fetal_cardiomyocyte0.88582103
107MP0009780_abnormal_chondrocyte_physiolo0.88352116
108MP0005380_embryogenesis_phenotype0.87254826
109MP0001672_abnormal_embryogenesis/_devel0.87254826
110MP0000716_abnormal_immune_system0.86636773
111MP0001905_abnormal_dopamine_level0.85999929
112MP0005389_reproductive_system_phenotype0.85794536
113MP0008469_abnormal_protein_level0.84888076
114MP0004272_abnormal_basement_membrane0.84374808
115MP0002419_abnormal_innate_immunity0.84221857
116MP0005584_abnormal_enzyme/coenzyme_acti0.84121106
117MP0009763_increased_sensitivity_to0.82603548
118MP0002160_abnormal_reproductive_system0.82512131
119MP0001216_abnormal_epidermal_layer0.81517177
120MP0003941_abnormal_skin_development0.80869572
121MP0008789_abnormal_olfactory_epithelium0.80839990
122MP0001119_abnormal_female_reproductive0.80228682
123MP0005636_abnormal_mineral_homeostasis0.79946416
124MP0000858_altered_metastatic_potential0.79065327
125MP0003724_increased_susceptibility_to0.78415046
126MP0001919_abnormal_reproductive_system0.77958807
127MP0002295_abnormal_pulmonary_circulatio0.77829679
128MP0008775_abnormal_heart_ventricle0.77172252
129MP0001542_abnormal_bone_strength0.76621399
130MP0001145_abnormal_male_reproductive0.76064462
131MP0003984_embryonic_growth_retardation0.76027417
132MP0002405_respiratory_system_inflammati0.74835798
133MP0009840_abnormal_foam_cell0.74614137
134MP0002088_abnormal_embryonic_growth/wei0.74597583
135MP0001845_abnormal_inflammatory_respons0.74382944
136MP0002060_abnormal_skin_morphology0.73810459
137MP0005330_cardiomyopathy0.73694284
138MP0005310_abnormal_salivary_gland0.73022654
139MP0000627_abnormal_mammary_gland0.72818589
140MP0002970_abnormal_white_adipose0.70708345
141MP0005376_homeostasis/metabolism_phenot0.70224281
142MP0005164_abnormal_response_to0.69801329
143MP0003448_altered_tumor_morphology0.69671722
144MP0004381_abnormal_hair_follicle0.69234373
145MP0000703_abnormal_thymus_morphology0.68933631
146MP0002751_abnormal_autonomic_nervous0.68789390
147MP0001929_abnormal_gametogenesis0.68122771
148MP0005166_decreased_susceptibility_to0.68106419
149MP0002277_abnormal_respiratory_mucosa0.67966228
150MP0000653_abnormal_sex_gland0.66988458
151MP0006054_spinal_hemorrhage0.66820691

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.77414029
2Reticulocytopenia (HP:0001896)4.48136833
3Abnormal number of erythroid precursors (HP:0012131)4.41331635
4Acute necrotizing encephalopathy (HP:0006965)4.19325364
5Birth length less than 3rd percentile (HP:0003561)4.10821800
6Macrocytic anemia (HP:0001972)3.99521298
7Mitochondrial inheritance (HP:0001427)3.90044572
8Increased hepatocellular lipid droplets (HP:0006565)3.72750842
9Abnormal mitochondria in muscle tissue (HP:0008316)3.66126064
10Increased CSF lactate (HP:0002490)3.60142569
11Breast hypoplasia (HP:0003187)3.56734005
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51875156
13Hepatocellular necrosis (HP:0001404)3.51074523
14Increased serum pyruvate (HP:0003542)3.49859937
15Abnormality of glycolysis (HP:0004366)3.49859937
16Acute encephalopathy (HP:0006846)3.49501568
17Oral leukoplakia (HP:0002745)3.49453458
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.44891450
19Abnormal gallbladder physiology (HP:0012438)3.41225674
20Cholecystitis (HP:0001082)3.41225674
213-Methylglutaconic aciduria (HP:0003535)3.37250562
22Lipid accumulation in hepatocytes (HP:0006561)3.36438748
23Hepatic necrosis (HP:0002605)3.31879355
24Upper limb muscle weakness (HP:0003484)3.23516172
25Progressive macrocephaly (HP:0004481)3.22059277
26Increased serum lactate (HP:0002151)3.20829387
27Pallor (HP:0000980)3.20249831
28Exertional dyspnea (HP:0002875)3.19262589
29Renal Fanconi syndrome (HP:0001994)3.15583243
30Hypokinesia (HP:0002375)3.10460958
31Abnormal protein glycosylation (HP:0012346)3.07985707
32Abnormal glycosylation (HP:0012345)3.07985707
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.07985707
34Abnormal protein N-linked glycosylation (HP:0012347)3.07985707
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.06166119
36Cerebral hypomyelination (HP:0006808)3.04809412
37Orthostatic hypotension (HP:0001278)3.00196805
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94446898
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94446898
40Cerebral edema (HP:0002181)2.85110198
41Generalized aminoaciduria (HP:0002909)2.78526776
42Rough bone trabeculation (HP:0100670)2.74060016
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73678614
44Aplastic anemia (HP:0001915)2.68522588
45Carpal bone hypoplasia (HP:0001498)2.60187456
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56555889
47Abnormality of alanine metabolism (HP:0010916)2.56555889
48Hyperalaninemia (HP:0003348)2.56555889
49Exercise intolerance (HP:0003546)2.52460577
50Microretrognathia (HP:0000308)2.50677713
51Multiple enchondromatosis (HP:0005701)2.46603966
52Respiratory failure (HP:0002878)2.45440773
53Respiratory difficulties (HP:0002880)2.45286833
54Hypophosphatemic rickets (HP:0004912)2.42895462
55Type I transferrin isoform profile (HP:0003642)2.42712666
56Poor head control (HP:0002421)2.41891629
57Lactic acidosis (HP:0003128)2.41071198
58Nausea (HP:0002018)2.40465302
59Conjunctival hamartoma (HP:0100780)2.39648859
60Abnormality of the anterior horn cell (HP:0006802)2.39594821
61Degeneration of anterior horn cells (HP:0002398)2.39594821
62Microvesicular hepatic steatosis (HP:0001414)2.35886386
63Secondary amenorrhea (HP:0000869)2.32263332
64Ragged-red muscle fibers (HP:0003200)2.30875593
65Cortical visual impairment (HP:0100704)2.29447202
66Abnormality of pyrimidine metabolism (HP:0004353)2.27130575
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26424608
68Increased intramyocellular lipid droplets (HP:0012240)2.26213442
69Amniotic constriction ring (HP:0009775)2.25969582
70Abnormality of placental membranes (HP:0011409)2.25969582
71Sensory axonal neuropathy (HP:0003390)2.25134440
72Emotional lability (HP:0000712)2.23873633
73Congenital ichthyosiform erythroderma (HP:0007431)2.22126867
74Hyperthyroidism (HP:0000836)2.21425435
75Abnormality of methionine metabolism (HP:0010901)2.20674269
76Tetraparesis (HP:0002273)2.20527145
7711 pairs of ribs (HP:0000878)2.17331317
78Abnormal trabecular bone morphology (HP:0100671)2.16755262
79Abnormality of the preputium (HP:0100587)2.15680103
80CNS demyelination (HP:0007305)2.12542862
81Absent thumb (HP:0009777)2.12528577
82Horseshoe kidney (HP:0000085)2.11156015
83Patellar aplasia (HP:0006443)2.11036022
84Meckel diverticulum (HP:0002245)2.10423883
85Leukodystrophy (HP:0002415)2.09673591
86Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09151154
87Abnormality of liposaccharide metabolism (HP:0010968)2.08014549
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.08014549
89Abnormality of glycolipid metabolism (HP:0010969)2.08014549
90Testicular atrophy (HP:0000029)2.06452934
91Agnosia (HP:0010524)2.06379123
92Prolonged neonatal jaundice (HP:0006579)2.06269665
93Severe visual impairment (HP:0001141)2.04746855
94Cellular immunodeficiency (HP:0005374)2.04161044
95Megaloblastic anemia (HP:0001889)2.04032415
96Vacuolated lymphocytes (HP:0001922)2.03166352
97Parakeratosis (HP:0001036)2.02564592
98Dicarboxylic aciduria (HP:0003215)2.02324327
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02324327
100Reduced antithrombin III activity (HP:0001976)1.99856036
101Hypergonadotropic hypogonadism (HP:0000815)1.99235780
102Abnormality of the ileum (HP:0001549)1.99106455
103Triphalangeal thumb (HP:0001199)1.98196008
104Cleft eyelid (HP:0000625)1.95924360
105Aplasia/Hypoplasia of the patella (HP:0006498)1.95830100
106Lethargy (HP:0001254)1.95512867
107Abnormality of chromosome stability (HP:0003220)1.94114355
108Hypobetalipoproteinemia (HP:0003563)1.93919365
109Pancytopenia (HP:0001876)1.93716759
110Stenosis of the external auditory canal (HP:0000402)1.93671574
111Trismus (HP:0000211)1.92970937
112Abnormal lung lobation (HP:0002101)1.92133099
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.92104979
114Premature graying of hair (HP:0002216)1.91743269
115Hyperammonemia (HP:0001987)1.91694731
116Glycosuria (HP:0003076)1.89614699
117Abnormality of urine glucose concentration (HP:0011016)1.89614699
118Increased muscle lipid content (HP:0009058)1.88975250
119Blindness (HP:0000618)1.88704289
120Methylmalonic aciduria (HP:0012120)1.87972645
121Hypertensive crisis (HP:0100735)1.87448196
122Aplasia/hypoplasia of the uterus (HP:0008684)1.86892590
123Petechiae (HP:0000967)1.86759335
124Redundant skin (HP:0001582)1.86759146
125Premature ovarian failure (HP:0008209)1.84963198
126Posterior subcapsular cataract (HP:0007787)1.83913318
127Cutaneous melanoma (HP:0012056)1.82980761
128Thrombocytosis (HP:0001894)1.82408214
129Abnormal hemoglobin (HP:0011902)1.82272443
130Abnormality of reticulocytes (HP:0004312)1.81263016
131Bone marrow hypocellularity (HP:0005528)1.80254890
132Colon cancer (HP:0003003)1.80015799
133Abnormality of renal resorption (HP:0011038)1.79990930
134Cutaneous photosensitivity (HP:0000992)1.79984227
135Resting tremor (HP:0002322)1.79354747
136Optic disc pallor (HP:0000543)1.79292191
137Recurrent abscess formation (HP:0002722)1.78769164
138Paralysis (HP:0003470)1.77973982
139Progressive external ophthalmoplegia (HP:0000590)1.77737267
140Entropion (HP:0000621)1.77688761
141Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77154068
142Congenital, generalized hypertrichosis (HP:0004540)1.76440640
143Recurrent bacterial skin infections (HP:0005406)1.75418579
144Methylmalonic acidemia (HP:0002912)1.75332932
145CNS hypomyelination (HP:0003429)1.72424195
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72369261
147Sparse eyelashes (HP:0000653)1.70945344
148Dyschromatopsia (HP:0007641)1.70925287
149Hamartoma of the eye (HP:0010568)1.70126479
150Autoamputation (HP:0001218)1.69409714
151Delusions (HP:0000746)1.69156345
152Tetraplegia (HP:0002445)1.68877235
153X-linked dominant inheritance (HP:0001423)1.67368986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.48993462
2NME23.78663340
3EIF2AK13.64358582
4STK163.46141566
5WEE13.34330126
6SRPK13.04813476
7MAPKAPK32.83297040
8MAP4K22.60811622
9EIF2AK32.45796310
10PDK22.45588041
11TLK12.21131050
12PIM22.14331585
13TSSK62.12318464
14TESK22.12277439
15PBK2.07032312
16PLK42.01984815
17MAP3K32.01805011
18VRK11.99982072
19NME11.89083725
20IRAK41.84143728
21CDC71.83534528
22BRSK21.72145508
23CSNK1A1L1.69980457
24MST41.67666669
25MAP3K51.66472607
26PASK1.65650167
27ACVR1B1.64887922
28VRK21.56350905
29TAOK11.51825883
30BLK1.47752700
31PLK11.42863552
32CSNK1G11.42285169
33DYRK31.40040941
34MKNK11.39100667
35MAP2K31.38682192
36IRAK31.38342493
37CSNK1G21.34654449
38TTK1.28998236
39TESK11.27367995
40NEK21.27159220
41DYRK21.25747079
42AURKB1.21364624
43TIE11.20382424
44ZAK1.20331046
45NEK91.19776679
46MATK1.18584783
47BRAF1.18383606
48CCNB11.15361244
49AURKA1.14746408
50DAPK11.14019914
51EIF2AK21.12608359
52LIMK11.12317945
53PLK31.11114081
54NTRK11.10686648
55BCKDK1.09648830
56BCR1.09416824
57KDR1.05339571
58BRSK11.01557635
59FES1.01383473
60CDK71.00127585
61TRIM280.97578446
62EPHA20.93950528
63MAP4K10.93633356
64ATR0.91795403
65ABL20.90299930
66NUAK10.90069335
67MAP3K10.88777387
68PLK20.88309327
69PINK10.83152895
70MKNK20.82827660
71TEC0.81907427
72TXK0.80931390
73RPS6KA40.78889906
74PIM10.78246931
75CSNK2A10.78181821
76RAF10.75670993
77ZAP700.74973378
78CDK80.74649081
79ALK0.74359390
80ARAF0.73223003
81NLK0.71830389
82FER0.71446304
83TBK10.71206162
84NEK10.70250176
85FRK0.69735289
86ERN10.69038779
87MAP3K80.67870068
88MAP3K110.67723117
89CSNK2A20.67654588
90PAK40.67423012
91STK40.63935022
92RPS6KA50.63429985
93SCYL20.62630553
94TGFBR10.62070315
95MARK30.61503754
96SIK30.61282716
97PRKCI0.61220602
98LMTK20.59595283
99CHEK20.59513692
100TYK20.59451751
101RPS6KB20.59365835
102PAK10.59341511
103LRRK20.58185557
104MAP2K70.57460358
105IRAK20.57400195
106EPHA30.56084981
107IRAK10.55616066
108IKBKB0.55376841
109STK38L0.55305212
110MAPKAPK20.52927305
111DAPK30.52570123
112YES10.51653290
113ILK0.50937162
114CDK40.50818779
115ADRBK20.49804117
116MYLK0.48791958
117CHEK10.48145117
118IKBKE0.47954659
119MAP3K100.47215891
120STK240.46426629
121MOS0.44603832
122TAOK20.43849974
123MAP3K140.41358406
124PRKG20.41034124
125BMPR20.40988927
126LYN0.39981353
127CSNK1G30.38253980
128WNK40.37554437
129PRKD20.37146347
130OBSCN0.35438630
131CLK10.34023904
132GRK70.33435206
133BTK0.33401260
134ATM0.32377217
135MAP2K60.32314384
136MAP3K120.32134513
137GRK10.31999727
138SYK0.31937784
139STK100.31775650
140GRK60.30941545
141CDK20.30728816
142MST1R0.30623024

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.96760479
2Ribosome_Homo sapiens_hsa030104.54244637
3DNA replication_Homo sapiens_hsa030303.68722139
4RNA polymerase_Homo sapiens_hsa030203.67536829
5Mismatch repair_Homo sapiens_hsa034303.14272598
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72692589
7Spliceosome_Homo sapiens_hsa030402.64957044
8Pyrimidine metabolism_Homo sapiens_hsa002402.59149491
9Homologous recombination_Homo sapiens_hsa034402.40658664
10Nucleotide excision repair_Homo sapiens_hsa034202.36965513
11Oxidative phosphorylation_Homo sapiens_hsa001902.34002455
12Protein export_Homo sapiens_hsa030602.31527093
13Sulfur metabolism_Homo sapiens_hsa009202.30165310
14Parkinsons disease_Homo sapiens_hsa050122.22829258
15RNA transport_Homo sapiens_hsa030132.15271408
16Base excision repair_Homo sapiens_hsa034102.14933707
17One carbon pool by folate_Homo sapiens_hsa006701.88816803
18Basal transcription factors_Homo sapiens_hsa030221.76693200
19Huntingtons disease_Homo sapiens_hsa050161.72307727
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66633773
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65825634
22Cell cycle_Homo sapiens_hsa041101.47190072
23Fanconi anemia pathway_Homo sapiens_hsa034601.45938658
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42397180
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35828622
26RNA degradation_Homo sapiens_hsa030181.32328050
27Purine metabolism_Homo sapiens_hsa002301.31175827
28Alzheimers disease_Homo sapiens_hsa050101.26920136
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25301682
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.20453843
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20067053
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15539313
33Epstein-Barr virus infection_Homo sapiens_hsa051691.09518796
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08634960
35Folate biosynthesis_Homo sapiens_hsa007901.08161284
36Propanoate metabolism_Homo sapiens_hsa006401.08072223
37Non-homologous end-joining_Homo sapiens_hsa034501.06679899
38N-Glycan biosynthesis_Homo sapiens_hsa005101.04506898
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03247281
40Vibrio cholerae infection_Homo sapiens_hsa051101.02342028
41Glutathione metabolism_Homo sapiens_hsa004801.02134322
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01903736
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98230166
44Collecting duct acid secretion_Homo sapiens_hsa049660.96661715
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.93557127
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93508373
47Pentose phosphate pathway_Homo sapiens_hsa000300.91944273
48p53 signaling pathway_Homo sapiens_hsa041150.91146968
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90600937
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88221625
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86942607
52Systemic lupus erythematosus_Homo sapiens_hsa053220.85606751
53Selenocompound metabolism_Homo sapiens_hsa004500.80583907
54Steroid biosynthesis_Homo sapiens_hsa001000.80231133
55Vitamin B6 metabolism_Homo sapiens_hsa007500.78683622
56Sulfur relay system_Homo sapiens_hsa041220.77777134
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76629435
58mRNA surveillance pathway_Homo sapiens_hsa030150.73525716
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72228794
60Antigen processing and presentation_Homo sapiens_hsa046120.68609243
61Biosynthesis of amino acids_Homo sapiens_hsa012300.67259714
62Carbon metabolism_Homo sapiens_hsa012000.66431151
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65762308
64Metabolic pathways_Homo sapiens_hsa011000.64625664
65Legionellosis_Homo sapiens_hsa051340.63647875
66Regulation of autophagy_Homo sapiens_hsa041400.61092895
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60263159
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.59855464
69Arachidonic acid metabolism_Homo sapiens_hsa005900.59360160
70Fatty acid metabolism_Homo sapiens_hsa012120.59101870
71Fatty acid elongation_Homo sapiens_hsa000620.59053975
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.58813908
73* Herpes simplex infection_Homo sapiens_hsa051680.57565203
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56964140
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.56263014
76Lysosome_Homo sapiens_hsa041420.53723900
77Peroxisome_Homo sapiens_hsa041460.51894556
78Allograft rejection_Homo sapiens_hsa053300.51702720
79Phenylalanine metabolism_Homo sapiens_hsa003600.51090030
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50554095
81Butanoate metabolism_Homo sapiens_hsa006500.49656301
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.47503269
83Fructose and mannose metabolism_Homo sapiens_hsa000510.47254307
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47175953
85Graft-versus-host disease_Homo sapiens_hsa053320.46866026
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.44727356
87Other glycan degradation_Homo sapiens_hsa005110.44286657
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43052576
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41659402
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41590429
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41433996
92Type I diabetes mellitus_Homo sapiens_hsa049400.41093618
93Arginine and proline metabolism_Homo sapiens_hsa003300.40855245
94Asthma_Homo sapiens_hsa053100.40297983
95Primary immunodeficiency_Homo sapiens_hsa053400.39376108
96Mineral absorption_Homo sapiens_hsa049780.39084742
97Pyruvate metabolism_Homo sapiens_hsa006200.38840981
98Rheumatoid arthritis_Homo sapiens_hsa053230.38424947
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36691067
100Retinol metabolism_Homo sapiens_hsa008300.35866195
101Tyrosine metabolism_Homo sapiens_hsa003500.35419270
102Vitamin digestion and absorption_Homo sapiens_hsa049770.35156650
103Chemical carcinogenesis_Homo sapiens_hsa052040.34811254
104Sphingolipid metabolism_Homo sapiens_hsa006000.34222511
105Phagosome_Homo sapiens_hsa041450.33916641
106Viral carcinogenesis_Homo sapiens_hsa052030.32945546
107Histidine metabolism_Homo sapiens_hsa003400.32636042
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32442624
109Staphylococcus aureus infection_Homo sapiens_hsa051500.31518907
110Caffeine metabolism_Homo sapiens_hsa002320.30956849
111Cardiac muscle contraction_Homo sapiens_hsa042600.29484824
112Shigellosis_Homo sapiens_hsa051310.28780834
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27626260
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.27609212
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27591041
116Autoimmune thyroid disease_Homo sapiens_hsa053200.27394109
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27034252
118Linoleic acid metabolism_Homo sapiens_hsa005910.26135288
119beta-Alanine metabolism_Homo sapiens_hsa004100.25414042
120Apoptosis_Homo sapiens_hsa042100.24513928
121Tryptophan metabolism_Homo sapiens_hsa003800.24510341
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23520751
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.23167070
124Galactose metabolism_Homo sapiens_hsa000520.21984458
125Complement and coagulation cascades_Homo sapiens_hsa046100.20715748
126Measles_Homo sapiens_hsa051620.20245547

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