MED9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.31869255
2viral transcription (GO:0019083)4.98064700
3regulation of posttranscriptional gene silencing (GO:0060147)4.92225844
4regulation of gene silencing by miRNA (GO:0060964)4.92225844
5regulation of gene silencing by RNA (GO:0060966)4.92225844
6translational termination (GO:0006415)4.89867254
7DNA strand elongation involved in DNA replication (GO:0006271)4.61021391
8translational elongation (GO:0006414)4.57613639
9kynurenine metabolic process (GO:0070189)4.44953481
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.44877842
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40033781
12DNA strand elongation (GO:0022616)4.34174130
13cotranslational protein targeting to membrane (GO:0006613)4.28943432
14protein targeting to ER (GO:0045047)4.28359427
15ribosomal small subunit assembly (GO:0000028)4.26872479
16telomere maintenance via semi-conservative replication (GO:0032201)4.25622680
17translational initiation (GO:0006413)4.22846039
18proteasome assembly (GO:0043248)4.22277589
19maturation of SSU-rRNA (GO:0030490)4.17897835
20ribosomal small subunit biogenesis (GO:0042274)4.17123619
21ribosomal large subunit biogenesis (GO:0042273)4.14738110
22indole-containing compound catabolic process (GO:0042436)4.08895488
23indolalkylamine catabolic process (GO:0046218)4.08895488
24tryptophan catabolic process (GO:0006569)4.08895488
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.07950530
26protein localization to endoplasmic reticulum (GO:0070972)4.07671670
27DNA replication initiation (GO:0006270)4.05846228
28formation of translation preinitiation complex (GO:0001731)3.98005075
29cellular protein complex disassembly (GO:0043624)3.97557573
30protein K48-linked deubiquitination (GO:0071108)3.97117631
31behavioral response to nicotine (GO:0035095)3.94756120
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94597976
33viral life cycle (GO:0019058)3.87186777
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.86596027
35DNA replication checkpoint (GO:0000076)3.85142138
36ribonucleoprotein complex biogenesis (GO:0022613)3.78703421
37indolalkylamine metabolic process (GO:0006586)3.74629256
38translation (GO:0006412)3.74068592
39spliceosomal snRNP assembly (GO:0000387)3.73994678
40cullin deneddylation (GO:0010388)3.69875451
41pseudouridine synthesis (GO:0001522)3.67581584
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67490834
43snRNA transcription (GO:0009301)3.66698405
44protein deneddylation (GO:0000338)3.62877187
45regulation of hippo signaling (GO:0035330)3.61517243
46deoxyribose phosphate biosynthetic process (GO:0046385)3.60537841
472-deoxyribonucleotide biosynthetic process (GO:0009265)3.60537841
48ribosome biogenesis (GO:0042254)3.60441883
49protein complex disassembly (GO:0043241)3.60060034
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55316414
51DNA unwinding involved in DNA replication (GO:0006268)3.54126642
52telomere maintenance via recombination (GO:0000722)3.54072619
53negative regulation of translation, ncRNA-mediated (GO:0040033)3.53807172
54regulation of translation, ncRNA-mediated (GO:0045974)3.53807172
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.53807172
56folic acid-containing compound biosynthetic process (GO:0009396)3.53777828
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52127148
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.52127148
59regulation of mitochondrial translation (GO:0070129)3.49526657
60tryptophan metabolic process (GO:0006568)3.49283322
61peptidyl-histidine modification (GO:0018202)3.46192901
62macromolecular complex disassembly (GO:0032984)3.45316334
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43314297
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42031970
65protein complex localization (GO:0031503)3.38642022
66negative regulation of ligase activity (GO:0051352)3.37789442
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37789442
68deoxyribonucleotide biosynthetic process (GO:0009263)3.37621039
69rRNA processing (GO:0006364)3.36007402
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35175066
71termination of RNA polymerase III transcription (GO:0006386)3.33784511
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.33784511
73nucleobase-containing small molecule interconversion (GO:0015949)3.33280724
74neural tube formation (GO:0001841)3.31396530
75protein K11-linked deubiquitination (GO:0035871)3.30762509
76regulation of collateral sprouting (GO:0048670)3.29613206
77aspartate family amino acid catabolic process (GO:0009068)3.28965479
78protein localization to kinetochore (GO:0034501)3.27990294
79piRNA metabolic process (GO:0034587)3.26666806
80nucleobase biosynthetic process (GO:0046112)3.24973758
81rRNA metabolic process (GO:0016072)3.23865497
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23258963
83ATP synthesis coupled proton transport (GO:0015986)3.23258963
84amino acid salvage (GO:0043102)3.22758624
85L-methionine salvage (GO:0071267)3.22758624
86L-methionine biosynthetic process (GO:0071265)3.22758624
87protein localization to chromosome, centromeric region (GO:0071459)3.22014677
88mitotic recombination (GO:0006312)3.20162884
89telomere maintenance via telomere lengthening (GO:0010833)3.20090592
90ribosome assembly (GO:0042255)3.19815143
91establishment of protein localization to mitochondrion (GO:0072655)3.18057142
92cellular component biogenesis (GO:0044085)3.16974687
93ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.16937993
94positive regulation of developmental pigmentation (GO:0048087)3.16240315
95purine nucleobase biosynthetic process (GO:0009113)3.15417114
96protein targeting to mitochondrion (GO:0006626)3.14790615
97regulation of translational termination (GO:0006449)3.14785319
98guanosine-containing compound biosynthetic process (GO:1901070)3.14758489
99response to misfolded protein (GO:0051788)3.13429397
100regulation of cellular amino acid metabolic process (GO:0006521)3.13207539
101DNA methylation involved in gamete generation (GO:0043046)3.11433466
102DNA replication-dependent nucleosome organization (GO:0034723)3.11408748
103DNA replication-dependent nucleosome assembly (GO:0006335)3.11408748
104pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10975119
105folic acid metabolic process (GO:0046655)3.09899659
106NAD biosynthetic process (GO:0009435)3.07016473
107detection of light stimulus involved in visual perception (GO:0050908)3.06893310
108detection of light stimulus involved in sensory perception (GO:0050962)3.06893310
109peptidyl-arginine omega-N-methylation (GO:0035247)3.06146000
110nucleotide-excision repair, DNA gap filling (GO:0006297)3.04890937
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04444102
112iron-sulfur cluster assembly (GO:0016226)3.04168333
113metallo-sulfur cluster assembly (GO:0031163)3.04168333
114protein K63-linked deubiquitination (GO:0070536)3.03772769
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02812257
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02017355
117protein targeting to membrane (GO:0006612)3.00977669
118pteridine-containing compound biosynthetic process (GO:0042559)3.00728935
119misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.00406515
120monoubiquitinated protein deubiquitination (GO:0035520)2.98732831
121nuclear-transcribed mRNA catabolic process (GO:0000956)2.97662483
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96470602
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96470602
124mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95629594
125mitochondrial respiratory chain complex I assembly (GO:0032981)2.95629594
126NADH dehydrogenase complex assembly (GO:0010257)2.95629594
127oxidative demethylation (GO:0070989)2.95460204
128rRNA modification (GO:0000154)2.94451331
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94162274
130establishment of integrated proviral latency (GO:0075713)2.93125223
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92387152
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92387152
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92387152
134protein maturation by protein folding (GO:0022417)2.91640025
135histone arginine methylation (GO:0034969)2.90829098
136G1/S transition of mitotic cell cycle (GO:0000082)2.90695147
137cell cycle G1/S phase transition (GO:0044843)2.90695147
138cellular biogenic amine catabolic process (GO:0042402)2.90351120
139amine catabolic process (GO:0009310)2.90351120
140signal transduction involved in DNA damage checkpoint (GO:0072422)2.89847188
141signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89847188
142spliceosomal complex assembly (GO:0000245)2.89797656
143positive regulation of ligase activity (GO:0051351)2.89224440
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88416445
145IMP biosynthetic process (GO:0006188)2.88261646
146CENP-A containing nucleosome assembly (GO:0034080)2.87609102
147negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.84876963
148detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82551798
149positive regulation of mitochondrial fission (GO:0090141)2.81499199
150dicarboxylic acid catabolic process (GO:0043649)2.79965089
151negative regulation of telomere maintenance (GO:0032205)2.78492515
152sulfation (GO:0051923)2.78239814
153male meiosis I (GO:0007141)2.74898657
154ubiquinone biosynthetic process (GO:0006744)2.71763174
155polyamine metabolic process (GO:0006595)2.71543973
156reciprocal DNA recombination (GO:0035825)2.68147591
157reciprocal meiotic recombination (GO:0007131)2.68147591
158photoreceptor cell maintenance (GO:0045494)2.67746692
159indole-containing compound metabolic process (GO:0042430)2.67543938
160ubiquinone metabolic process (GO:0006743)2.67182811
161methionine biosynthetic process (GO:0009086)2.66432033
162anterograde synaptic vesicle transport (GO:0048490)2.63830345
163rRNA catabolic process (GO:0016075)2.62105518
164mitochondrial respiratory chain complex assembly (GO:0033108)2.61293220
165base-excision repair, AP site formation (GO:0006285)2.60792115
166mitochondrial RNA metabolic process (GO:0000959)2.60511131
167protein complex biogenesis (GO:0070271)2.59336815
168negative regulation of mast cell activation (GO:0033004)2.58597270
169regulation of skeletal muscle contraction (GO:0014819)2.57930489
170regulation of sarcomere organization (GO:0060297)2.57673503
171neuronal action potential propagation (GO:0019227)2.55870233
172synaptic vesicle docking involved in exocytosis (GO:0016081)2.54224619
173gamma-aminobutyric acid transport (GO:0015812)2.53848579
174pyrimidine nucleobase catabolic process (GO:0006208)2.52321158
175transcription from RNA polymerase III promoter (GO:0006383)2.49163012
176adult walking behavior (GO:0007628)2.47638254
177pyrimidine dimer repair (GO:0006290)2.46550603
178fucose catabolic process (GO:0019317)2.44571702
179L-fucose metabolic process (GO:0042354)2.44571702
180L-fucose catabolic process (GO:0042355)2.44571702
181negative regulation of cell cycle G2/M phase transition (GO:1902750)2.44021800
182histone H3-K9 methylation (GO:0051567)2.43853202
183sulfur amino acid biosynthetic process (GO:0000097)2.42240046
184regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41797136
185respiratory chain complex IV assembly (GO:0008535)2.40743161
186aromatic amino acid family catabolic process (GO:0009074)2.40049231
187RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38466315
188aromatic amino acid family metabolic process (GO:0009072)2.36326902
189regulation of short-term neuronal synaptic plasticity (GO:0048172)2.35740898
190regulation of telomere maintenance (GO:0032204)2.35451042
191protein polyglutamylation (GO:0018095)2.34854513
192negative regulation of sodium ion transport (GO:0010766)2.34416424
193retinal cone cell development (GO:0046549)2.34408412
194flavonoid metabolic process (GO:0009812)2.31320735
195synaptic vesicle endocytosis (GO:0048488)2.31122798
196cilium or flagellum-dependent cell motility (GO:0001539)2.30992344
197regulation of chromatin binding (GO:0035561)2.30100328
198regulation of cilium movement (GO:0003352)2.28815602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06840371
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.59578809
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.34665860
4ZNF274_21170338_ChIP-Seq_K562_Hela4.09258247
5IGF1R_20145208_ChIP-Seq_DFB_Human3.46832703
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35354368
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.25982735
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.19033375
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18430860
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.12824433
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97403939
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.93623354
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.90167041
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87469331
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84757589
16EZH2_22144423_ChIP-Seq_EOC_Human2.81346555
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76398961
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73181772
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63027573
20XRN2_22483619_ChIP-Seq_HELA_Human2.62574584
21IRF1_19129219_ChIP-ChIP_H3396_Human2.46098541
22VDR_22108803_ChIP-Seq_LS180_Human2.40940497
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31532825
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.25701594
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22305846
26VDR_23849224_ChIP-Seq_CD4+_Human2.20448480
27DCP1A_22483619_ChIP-Seq_HELA_Human2.19200553
28TAF15_26573619_Chip-Seq_HEK293_Human2.18863432
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18072749
30GABP_19822575_ChIP-Seq_HepG2_Human2.15608976
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15067741
32GBX2_23144817_ChIP-Seq_PC3_Human2.14164465
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10323670
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10205070
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03821190
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01483594
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94988363
38TTF2_22483619_ChIP-Seq_HELA_Human1.94758321
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93421612
40FOXP3_21729870_ChIP-Seq_TREG_Human1.89394686
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87912839
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86990973
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84925081
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82331808
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.80329618
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77465756
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74221429
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73845498
49REST_21632747_ChIP-Seq_MESCs_Mouse1.73634442
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70236041
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68608173
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67201500
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65849611
54MYC_22102868_ChIP-Seq_BL_Human1.63618746
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59892158
56CIITA_25753668_ChIP-Seq_RAJI_Human1.57978279
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55442936
58MYC_18940864_ChIP-ChIP_HL60_Human1.54957642
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52729316
60ZNF263_19887448_ChIP-Seq_K562_Human1.50381797
61TP53_22573176_ChIP-Seq_HFKS_Human1.50237690
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50152496
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50051187
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49231633
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48555104
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48250412
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48197712
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47883175
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47295110
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.46647372
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46221523
72EWS_26573619_Chip-Seq_HEK293_Human1.45827722
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45332493
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42554026
75ERA_21632823_ChIP-Seq_H3396_Human1.42519559
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42359319
77DROSHA_22980978_ChIP-Seq_HELA_Human1.42148909
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.41639448
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.40370479
80FUS_26573619_Chip-Seq_HEK293_Human1.40238126
81* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39872989
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39698144
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38552836
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36752873
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33982066
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33447568
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33060736
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31792650
89VDR_21846776_ChIP-Seq_THP-1_Human1.30639849
90AR_21909140_ChIP-Seq_LNCAP_Human1.27509966
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26755673
92KDM5A_27292631_Chip-Seq_BREAST_Human1.26551507
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25085412
94STAT3_23295773_ChIP-Seq_U87_Human1.24732253
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24170206
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23253952
97* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23175977
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22967857
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22967857
100ER_23166858_ChIP-Seq_MCF-7_Human1.21297739
101* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20592098
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.20387039
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20077750
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19701181
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19404463
106OCT4_20526341_ChIP-Seq_ESCs_Human1.19088203
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17248268
108FOXP1_21924763_ChIP-Seq_HESCs_Human1.17053082
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16791951
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15944159
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13339424
112NCOR_22424771_ChIP-Seq_293T_Human1.11570830
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10719978
114MYC_19829295_ChIP-Seq_ESCs_Human1.09652097
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08898479
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.08875617
117HOXB7_26014856_ChIP-Seq_BT474_Human1.08603546
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08262340
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07932427
120RNF2_27304074_Chip-Seq_NSC_Mouse1.07796585
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06736294
122* TCF4_23295773_ChIP-Seq_U87_Human1.06140145
123CBP_20019798_ChIP-Seq_JUKART_Human1.06067170
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06067170
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05534562
126* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04696634
127TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03856563
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03330697
129* GATA3_21878914_ChIP-Seq_MCF-7_Human1.03315267
130* RAC3_21632823_ChIP-Seq_H3396_Human1.02676903
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02584464
132P300_19829295_ChIP-Seq_ESCs_Human1.02548969
133TET1_21451524_ChIP-Seq_MESCs_Mouse1.02172165
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02003705
135TFEB_21752829_ChIP-Seq_HELA_Human0.99816395
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99295097
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99275263
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97580633
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97123538
140SCL_19346495_ChIP-Seq_HPC-7_Human0.96957371
141* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96263609
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96247861
143* WDR5_24793694_ChIP-Seq_LNCAP_Human0.95777132
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.95558970
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95389885
146P53_21459846_ChIP-Seq_SAOS-2_Human0.94863280
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94232747
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.93873500
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93325448
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93098546
151ELK1_19687146_ChIP-ChIP_HELA_Human0.92362586
152PHF8_20622854_ChIP-Seq_HELA_Human0.92345612
153GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92171476
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92062940
155OCT4_19829295_ChIP-Seq_ESCs_Human0.91850840
156* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91174450
157FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90831483
158RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90516018
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89018240
160OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88943621
161SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88547555
162LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86473772
163SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86304706
164* ELK1_22589737_ChIP-Seq_MCF10A_Human0.86300197
165NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84432564
166RUNX2_22187159_ChIP-Seq_PCA_Human0.84157021
167RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83893439
168* AR_20517297_ChIP-Seq_VCAP_Human0.83439238
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83373842
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.83185314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.77819382
2MP0004957_abnormal_blastocyst_morpholog4.57613326
3MP0003111_abnormal_nucleus_morphology3.52879906
4MP0010094_abnormal_chromosome_stability3.33867871
5MP0003077_abnormal_cell_cycle3.07656225
6MP0003646_muscle_fatigue3.06124831
7MP0008932_abnormal_embryonic_tissue2.72332795
8MP0005410_abnormal_fertilization2.60731615
9MP0003136_yellow_coat_color2.56169423
10MP0009046_muscle_twitch2.50696592
11MP0006036_abnormal_mitochondrial_physio2.47586579
12MP0008058_abnormal_DNA_repair2.34478979
13MP0009379_abnormal_foot_pigmentation2.32653481
14MP0001730_embryonic_growth_arrest2.26791274
15MP0003123_paternal_imprinting2.13923290
16MP0008877_abnormal_DNA_methylation2.09303059
17MP0001984_abnormal_olfaction2.05468890
18MP0002736_abnormal_nociception_after2.03473993
19MP0002396_abnormal_hematopoietic_system2.00877743
20MP0001501_abnormal_sleep_pattern1.99599273
21MP0006035_abnormal_mitochondrial_morpho1.96640839
22MP0008007_abnormal_cellular_replicative1.94950004
23MP0000358_abnormal_cell_content/1.86726410
24MP0000350_abnormal_cell_proliferation1.78083627
25MP0006276_abnormal_autonomic_nervous1.77756041
26MP0003656_abnormal_erythrocyte_physiolo1.77017626
27MP0003878_abnormal_ear_physiology1.76554392
28MP0005377_hearing/vestibular/ear_phenot1.76554392
29MP0003195_calcinosis1.74512950
30MP0005551_abnormal_eye_electrophysiolog1.67956851
31MP0004215_abnormal_myocardial_fiber1.67276118
32MP0002080_prenatal_lethality1.66118409
33MP0001697_abnormal_embryo_size1.62872591
34MP0000490_abnormal_crypts_of1.61353893
35MP0000749_muscle_degeneration1.57871771
36MP0009745_abnormal_behavioral_response1.57327267
37MP0004084_abnormal_cardiac_muscle1.56884928
38MP0002653_abnormal_ependyma_morphology1.54162014
39MP0000313_abnormal_cell_death1.51970499
40MP0001929_abnormal_gametogenesis1.50347508
41MP0002837_dystrophic_cardiac_calcinosis1.49878095
42MP0003635_abnormal_synaptic_transmissio1.47101335
43MP0002269_muscular_atrophy1.46819054
44MP0005670_abnormal_white_adipose1.46731997
45MP0002064_seizures1.46072331
46MP0000750_abnormal_muscle_regeneration1.46033197
47MP0001486_abnormal_startle_reflex1.46005844
48MP0001485_abnormal_pinna_reflex1.45120383
49MP0005167_abnormal_blood-brain_barrier1.41892946
50MP0002272_abnormal_nervous_system1.41322145
51MP0003806_abnormal_nucleotide_metabolis1.39815953
52MP0002210_abnormal_sex_determination1.37516068
53MP0001145_abnormal_male_reproductive1.36581812
54MP0003221_abnormal_cardiomyocyte_apopto1.35328996
55MP0005645_abnormal_hypothalamus_physiol1.34649553
56MP0008057_abnormal_DNA_replication1.33432044
57MP0000747_muscle_weakness1.32902155
58MP0005083_abnormal_biliary_tract1.32306671
59MP0005330_cardiomyopathy1.32234621
60MP0003786_premature_aging1.31782567
61MP0008961_abnormal_basal_metabolism1.31697221
62MP0002160_abnormal_reproductive_system1.30077937
63MP0002572_abnormal_emotion/affect_behav1.29238242
64MP0003698_abnormal_male_reproductive1.28907992
65MP0001672_abnormal_embryogenesis/_devel1.27696648
66MP0005380_embryogenesis_phenotype1.27696648
67MP0002332_abnormal_exercise_endurance1.26480761
68MP0005253_abnormal_eye_physiology1.25787891
69MP0005397_hematopoietic_system_phenotyp1.25290831
70MP0001545_abnormal_hematopoietic_system1.25290831
71MP0002063_abnormal_learning/memory/cond1.22800148
72MP0002638_abnormal_pupillary_reflex1.20387951
73MP0004233_abnormal_muscle_weight1.19039981
74MP0002085_abnormal_embryonic_tissue1.18441924
75MP0000751_myopathy1.16634293
76MP0004142_abnormal_muscle_tone1.16601875
77MP0003984_embryonic_growth_retardation1.16303699
78MP0010352_gastrointestinal_tract_polyps1.14813449
79MP0003890_abnormal_embryonic-extraembry1.14453535
80MP0002019_abnormal_tumor_incidence1.13708385
81MP0003119_abnormal_digestive_system1.12992909
82MP0009333_abnormal_splenocyte_physiolog1.12411307
83MP0002067_abnormal_sensory_capabilities1.12406733
84MP0002084_abnormal_developmental_patter1.12263725
85MP0002088_abnormal_embryonic_growth/wei1.10749587
86MP0005386_behavior/neurological_phenoty1.06951886
87MP0004924_abnormal_behavior1.06951886
88MP0004147_increased_porphyrin_level1.04501450
89MP0003186_abnormal_redox_activity1.02925238
90MP0000653_abnormal_sex_gland1.02419357
91MP0004130_abnormal_muscle_cell1.02415844
92MP0008872_abnormal_physiological_respon1.00855506
93MP0003879_abnormal_hair_cell1.00787840
94MP0002229_neurodegeneration1.00438907
95MP0002733_abnormal_thermal_nociception0.96087715
96MP0000015_abnormal_ear_pigmentation0.95940148
97MP0001986_abnormal_taste_sensitivity0.95699596
98MP0001727_abnormal_embryo_implantation0.94818379
99MP0004859_abnormal_synaptic_plasticity0.94569799
100MP0001970_abnormal_pain_threshold0.94414753
101MP0004036_abnormal_muscle_relaxation0.94200899
102MP0002557_abnormal_social/conspecific_i0.93600490
103MP0004145_abnormal_muscle_electrophysio0.92934920
104MP0002735_abnormal_chemical_nociception0.92493473
105MP0000631_abnormal_neuroendocrine_gland0.91260010
106MP0005647_abnormal_sex_gland0.90610022
107MP0003315_abnormal_perineum_morphology0.90586121
108MP0004085_abnormal_heartbeat0.90580982
109MP0002909_abnormal_adrenal_gland0.90108723
110MP0003787_abnormal_imprinting0.89139760
111MP0001764_abnormal_homeostasis0.89115592
112MP0000759_abnormal_skeletal_muscle0.88554221
113MP0005384_cellular_phenotype0.87088074
114MP0003718_maternal_effect0.86044221
115MP0004043_abnormal_pH_regulation0.85984686
116MP0006054_spinal_hemorrhage0.85719542
117MP0005646_abnormal_pituitary_gland0.85379800
118MP0002106_abnormal_muscle_physiology0.85181540
119MP0004808_abnormal_hematopoietic_stem0.84652158
120MP0001324_abnormal_eye_pigmentation0.84428106
121MP0004858_abnormal_nervous_system0.83056313
122MP0005499_abnormal_olfactory_system0.82939401
123MP0005394_taste/olfaction_phenotype0.82939401
124MP0005423_abnormal_somatic_nervous0.82633467
125MP0002734_abnormal_mechanical_nocicepti0.82343070
126MP0002161_abnormal_fertility/fecundity0.82292198
127MP0000569_abnormal_digit_pigmentation0.81544915
128MP0005266_abnormal_metabolism0.80782934
129MP0002086_abnormal_extraembryonic_tissu0.80126738
130MP0000778_abnormal_nervous_system0.79920367
131MP0001963_abnormal_hearing_physiology0.79901496
132MP0001502_abnormal_circadian_rhythm0.79647124
133MP0000858_altered_metastatic_potential0.75827379
134MP0002882_abnormal_neuron_morphology0.75705456
135MP0000049_abnormal_middle_ear0.75385486
136MP0000372_irregular_coat_pigmentation0.75144003
137MP0004087_abnormal_muscle_fiber0.74958872
138MP0006292_abnormal_olfactory_placode0.74585364
139MP0010030_abnormal_orbit_morphology0.73398864
140MP0008789_abnormal_olfactory_epithelium0.73276335
141MP0010307_abnormal_tumor_latency0.72716746
142MP0010386_abnormal_urinary_bladder0.72444489
143MP0008770_decreased_survivor_rate0.71923203
144MP0003137_abnormal_impulse_conducting0.71770252
145MP0000703_abnormal_thymus_morphology0.71288549
146MP0002752_abnormal_somatic_nervous0.71214878
147MP0002102_abnormal_ear_morphology0.70695932
148MP0004270_analgesia0.69512776
149MP0004811_abnormal_neuron_physiology0.68099482
150MP0002234_abnormal_pharynx_morphology0.66840148
151MP0000678_abnormal_parathyroid_gland0.66834091
152MP0005621_abnormal_cell_physiology0.66416118
153MP0004133_heterotaxia0.65406644
154MP0001968_abnormal_touch/_nociception0.63982641
155MP0003567_abnormal_fetal_cardiomyocyte0.63967800
156MP0001529_abnormal_vocalization0.63909543

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.48603356
2Abnormal number of erythroid precursors (HP:0012131)5.27345395
3Genetic anticipation (HP:0003743)4.25257563
4Progressive muscle weakness (HP:0003323)4.15669158
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.12984908
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.12984908
7Reticulocytopenia (HP:0001896)4.03598765
8Microretrognathia (HP:0000308)3.72242416
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.69386540
10Cerebral hypomyelination (HP:0006808)3.59943868
11Clumsiness (HP:0002312)3.52160539
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.40243866
13Abnormality of alanine metabolism (HP:0010916)3.40243866
14Hyperalaninemia (HP:0003348)3.40243866
15Hepatocellular necrosis (HP:0001404)3.38497044
16Hyperventilation (HP:0002883)3.34376993
17Pallor (HP:0000980)3.30634797
18Macrocytic anemia (HP:0001972)3.27751978
19Progressive cerebellar ataxia (HP:0002073)3.27250610
20Protruding tongue (HP:0010808)3.26106593
21Carpal bone hypoplasia (HP:0001498)3.24874801
22Multiple enchondromatosis (HP:0005701)3.21209263
23Abnormal mitochondria in muscle tissue (HP:0008316)3.21089792
24Acute necrotizing encephalopathy (HP:0006965)3.19054593
25Mitochondrial inheritance (HP:0001427)3.13686553
26Inability to walk (HP:0002540)3.12224276
27Aplastic anemia (HP:0001915)3.11572281
28Hepatic necrosis (HP:0002605)3.05582023
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.05019173
30Attenuation of retinal blood vessels (HP:0007843)3.03274002
31Progressive inability to walk (HP:0002505)3.03260746
32Gaze-evoked nystagmus (HP:0000640)3.03225297
33Increased serum lactate (HP:0002151)2.96912151
34Abnormality of the anterior horn cell (HP:0006802)2.96740856
35Degeneration of anterior horn cells (HP:0002398)2.96740856
36Increased CSF lactate (HP:0002490)2.92080324
37Birth length less than 3rd percentile (HP:0003561)2.89155005
38Rough bone trabeculation (HP:0100670)2.79686716
39Congenital stationary night blindness (HP:0007642)2.79231532
40Emotional lability (HP:0000712)2.75797089
41Patellar aplasia (HP:0006443)2.72940364
42Unsteady gait (HP:0002317)2.72354304
43Oral leukoplakia (HP:0002745)2.71245496
44Pancreatic cysts (HP:0001737)2.70509469
45Testicular atrophy (HP:0000029)2.65698232
46Broad-based gait (HP:0002136)2.62411480
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61370060
48Trismus (HP:0000211)2.57453083
49Type II lissencephaly (HP:0007260)2.55741638
50Adenoma sebaceum (HP:0009720)2.51977466
51Angiofibromas (HP:0010615)2.51977466
52Increased intramyocellular lipid droplets (HP:0012240)2.51437266
53Breast hypoplasia (HP:0003187)2.49348866
54Absent speech (HP:0001344)2.48459929
55Lactic acidosis (HP:0003128)2.47792545
56Aplasia/Hypoplasia of the patella (HP:0006498)2.47775871
57Exercise intolerance (HP:0003546)2.46361451
58Lissencephaly (HP:0001339)2.46297932
59Poor head control (HP:0002421)2.45323539
60Ragged-red muscle fibers (HP:0003200)2.43845315
61Urinary bladder sphincter dysfunction (HP:0002839)2.40603159
62Retinal dysplasia (HP:0007973)2.36580278
63Increased cerebral lipofuscin (HP:0011813)2.36490567
64Visual hallucinations (HP:0002367)2.36055277
65Acute encephalopathy (HP:0006846)2.34643681
66Respiratory failure (HP:0002878)2.33153618
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33032511
68Dysmetric saccades (HP:0000641)2.31935884
69Drooling (HP:0002307)2.30990851
70Increased hepatocellular lipid droplets (HP:0006565)2.30358898
71Increased muscle lipid content (HP:0009058)2.30294053
72Bony spicule pigmentary retinopathy (HP:0007737)2.29182210
73Pancreatic fibrosis (HP:0100732)2.26895841
74Gait imbalance (HP:0002141)2.25908781
75Partial agenesis of the corpus callosum (HP:0001338)2.25358586
76Progressive macrocephaly (HP:0004481)2.25348142
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.24374116
78Medial flaring of the eyebrow (HP:0010747)2.23947891
79Irregular epiphyses (HP:0010582)2.23474000
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.21716454
81Febrile seizures (HP:0002373)2.20703727
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20676035
83Congenital primary aphakia (HP:0007707)2.19426983
84Postnatal microcephaly (HP:0005484)2.19374879
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17381169
86Secondary amenorrhea (HP:0000869)2.17162444
87Abolished electroretinogram (ERG) (HP:0000550)2.16998437
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16519484
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15869044
90Delusions (HP:0000746)2.15093924
91Lipid accumulation in hepatocytes (HP:0006561)2.12785880
92Excessive salivation (HP:0003781)2.12042063
93Type I transferrin isoform profile (HP:0003642)2.11771556
94Difficulty climbing stairs (HP:0003551)2.10896571
95Pendular nystagmus (HP:0012043)2.10782081
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07916001
97Colon cancer (HP:0003003)2.07364656
98Dialeptic seizures (HP:0011146)2.05918459
99Opisthotonus (HP:0002179)2.04239248
100Poor eye contact (HP:0000817)2.00103943
101Focal seizures (HP:0007359)2.00021093
102CNS hypomyelination (HP:0003429)1.99848630
103Nephronophthisis (HP:0000090)1.98700898
104Hypoplasia of the pons (HP:0012110)1.97989199
105Postural instability (HP:0002172)1.97737661
106Facial diplegia (HP:0001349)1.97055791
107Myokymia (HP:0002411)1.96528085
108Personality changes (HP:0000751)1.96166287
109Aplasia/Hypoplasia of the tibia (HP:0005772)1.94929699
110Absent radius (HP:0003974)1.94265460
111Areflexia of lower limbs (HP:0002522)1.93641949
112Exertional dyspnea (HP:0002875)1.93553851
113True hermaphroditism (HP:0010459)1.93124234
114Premature ovarian failure (HP:0008209)1.93114882
115Achilles tendon contracture (HP:0001771)1.92716350
116Abnormality of reticulocytes (HP:0004312)1.92681978
117Abnormal protein glycosylation (HP:0012346)1.90303610
118Abnormal glycosylation (HP:0012345)1.90303610
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90303610
120Abnormal protein N-linked glycosylation (HP:0012347)1.90303610
121Aplasia involving forearm bones (HP:0009822)1.90261504
122Absent forearm bone (HP:0003953)1.90261504
123Insomnia (HP:0100785)1.89391013
124Abnormality of the renal collecting system (HP:0004742)1.89233892
125Poor coordination (HP:0002370)1.86315325
126CNS demyelination (HP:0007305)1.86267165
127Abnormal trabecular bone morphology (HP:0100671)1.85703127
128Selective tooth agenesis (HP:0001592)1.85430857
129Molar tooth sign on MRI (HP:0002419)1.84977390
130Abnormality of midbrain morphology (HP:0002418)1.84977390
131Stomach cancer (HP:0012126)1.84657690
132Neoplasm of the pancreas (HP:0002894)1.84184216
133Nephrogenic diabetes insipidus (HP:0009806)1.84115690
134Hypsarrhythmia (HP:0002521)1.83337487
135Abnormality of the pons (HP:0007361)1.83164384
136Cerebellar dysplasia (HP:0007033)1.80638467
137Neuroendocrine neoplasm (HP:0100634)1.80426464
138Chronic hepatic failure (HP:0100626)1.80344867
139Abnormality of the renal medulla (HP:0100957)1.80254458
140Microvesicular hepatic steatosis (HP:0001414)1.80000216
141Retinitis pigmentosa (HP:0000510)1.79868965
1423-Methylglutaconic aciduria (HP:0003535)1.79469981
143Chronic bronchitis (HP:0004469)1.79310195
144Epileptic encephalopathy (HP:0200134)1.78937674
145Ependymoma (HP:0002888)1.77314722
146Muscle fibrillation (HP:0010546)1.76760793
147Central scotoma (HP:0000603)1.76234224
148Tongue fasciculations (HP:0001308)1.76040396
149Abnormality of glycolysis (HP:0004366)1.75984467
150Increased serum pyruvate (HP:0003542)1.75984467
151Pancytopenia (HP:0001876)1.75642705
152Muscle fiber atrophy (HP:0100295)1.75262595
153Abnormality of the renal cortex (HP:0011035)1.74466734
154Glossoptosis (HP:0000162)1.74329944
155Cleft eyelid (HP:0000625)1.74083592
156Megaloblastic anemia (HP:0001889)1.74072613
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.73648114
158Reduced antithrombin III activity (HP:0001976)1.73020259
159Hypoplasia of the fovea (HP:0007750)1.72842373
160Aplasia/Hypoplasia of the fovea (HP:0008060)1.72842373
161Absent thumb (HP:0009777)1.72323176
162Fair hair (HP:0002286)1.72177572
163EEG with generalized epileptiform discharges (HP:0011198)1.72085633
164Absent epiphyses (HP:0010577)1.71273460
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71273460
166Rhabdomyolysis (HP:0003201)1.71175064
167Genital tract atresia (HP:0001827)1.69983469
168Abnormality of the nasal mucosa (HP:0000433)1.68875903
169Nasal polyposis (HP:0100582)1.68638992
170Vaginal atresia (HP:0000148)1.68427038
171Duplicated collecting system (HP:0000081)1.67939933
172Hyperglycinuria (HP:0003108)1.67556444
173Epileptiform EEG discharges (HP:0011182)1.67103514
174Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67054393
175Astrocytoma (HP:0009592)1.63073097
176Abnormality of the astrocytes (HP:0100707)1.63073097
177External ophthalmoplegia (HP:0000544)1.62476778
178Progressive microcephaly (HP:0000253)1.61984775
179Decreased circulating renin level (HP:0003351)1.60675484
180Intellectual disability, severe (HP:0010864)1.59281972
181Spastic paraplegia (HP:0001258)1.59191939
182Small hand (HP:0200055)1.57892773
183Dyskinesia (HP:0100660)1.56436288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.21003905
2BUB14.60418616
3EIF2AK14.06857590
4WEE13.89948962
5CDK123.49308911
6STK163.35448364
7BMPR1B3.05998597
8NME23.04476084
9TAOK32.98233108
10NEK12.64695597
11SCYL22.56785309
12ZAK2.47525960
13TESK22.41844222
14CDC72.25231345
15MAP2K72.24632978
16MAP3K112.17245603
17TESK12.13751921
18BRSK22.11051756
19NEK22.10758797
20TLK12.09765000
21MAP3K41.96810664
22NME11.86486414
23EIF2AK31.85456940
24WNK31.79216397
25DAPK21.77182643
26PDK31.75797597
27PDK41.75797597
28MAP4K21.72761454
29DYRK31.67549471
30MAPKAPK31.67096772
31MAPK131.64424438
32AKT31.63230959
33BRSK11.61424995
34ADRBK21.60157938
35CAMKK21.59287083
36INSRR1.55876046
37KDR1.54398551
38PIM21.53609915
39ACVR1B1.53328286
40FLT31.49738254
41OBSCN1.47127888
42PBK1.44365499
43ARAF1.40215611
44CSNK1A1L1.37976806
45TAOK11.36086120
46RPS6KA41.35795146
47AURKA1.32030944
48VRK11.30917195
49CAMK1D1.26082832
50BRD41.25283411
51TRIB31.23865318
52CDK191.20294724
53PLK11.18196906
54KSR21.14779478
55CSNK1G21.13827787
56CSNK1G31.13584142
57RPS6KB21.11720684
58PLK41.11331558
59LIMK11.08246882
60PAK41.07354896
61OXSR11.06782043
62STK38L1.06708985
63MAP3K101.03534014
64PRKD31.02745719
65MINK11.01924369
66CSNK1G11.01053091
67MAP3K71.00904737
68PKN21.00782088
69CAMK1G0.99386398
70BCKDK0.99232485
71BRAF0.98259321
72TTK0.97787802
73MKNK20.97265340
74MAP3K90.96745555
75GRK10.95334485
76TNK20.91824962
77CAMK40.89086823
78MAP3K80.87705390
79LRRK20.87585169
80EEF2K0.86878979
81RPS6KA50.86512117
82RAF10.85959841
83CAMK10.85237801
84CDK70.85162219
85ADRBK10.84402168
86PAK10.84315054
87AURKB0.84295436
88PRKAA10.81711383
89CCNB10.80026618
90ILK0.76850634
91PRKCG0.75993763
92PIM10.74420503
93SRPK10.73668102
94CASK0.73373643
95DAPK10.73118990
96EPHA40.72946914
97PASK0.69549357
98LATS20.67991670
99MELK0.67439163
100GRK50.67144361
101CHEK20.66295034
102LMTK20.65479820
103NUAK10.63841179
104CDK140.63336227
105PINK10.62588367
106CAMKK10.62071518
107PKN10.62046165
108CDK40.60258622
109DAPK30.59893378
110PIK3CG0.59174602
111PDK20.58795727
112MAPK110.56397076
113PRKAA20.55592873
114ATR0.54211091
115STK380.51276682
116SIK20.50438757
117CSNK1A10.50420137
118CDK11A0.49084661
119DYRK1A0.48905092
120MARK20.47964033
121DYRK1B0.47390585
122GRK60.47261303
123ICK0.46927919
124MAP2K40.45986963
125CDK150.45714293
126PRKG20.45671591
127CAMK2A0.45603829
128AKT20.45594280
129ABL20.45532240
130PAK60.45391408
131ALK0.45377665
132MARK10.44592830
133CSNK2A20.44578991
134CSNK2A10.43526253
135CDK180.43315054
136CHEK10.42495196
137RPS6KA60.42096644
138GSK3B0.41994388
139MAP4K10.41878336
140TGFBR10.41856488
141MAP3K50.41836183
142TRIM280.41514902
143NTRK30.40297192
144UHMK10.39794280
145PRKACB0.39358752
146STK110.39016955
147TSSK60.38763085
148PAK30.38389306
149MAP3K120.38143119
150LATS10.38091462
151CSNK1D0.37745179
152EPHA20.37423772
153MAPK100.36785573
154MAP2K30.35980074
155CDK50.35484265
156TAOK20.35435113
157MKNK10.35256035
158CDK10.33962987
159ATM0.33850707
160PRKACA0.33801956
161MAP3K10.33304656
162CDK20.32596501
163NTRK20.32528317
164PRKCI0.30807906
165DYRK20.29787602
166CSF1R0.28896748
167NTRK10.28578089
168MAP2K60.28109260
169PHKG10.27947822
170PHKG20.27947822

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79850962
2Ribosome_Homo sapiens_hsa030104.66679324
3Proteasome_Homo sapiens_hsa030504.00411882
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.71639118
5Mismatch repair_Homo sapiens_hsa034303.53664158
6RNA polymerase_Homo sapiens_hsa030203.38283813
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91401010
8Spliceosome_Homo sapiens_hsa030402.74637107
9Base excision repair_Homo sapiens_hsa034102.72212880
10Pyrimidine metabolism_Homo sapiens_hsa002402.71541654
11RNA transport_Homo sapiens_hsa030132.58019560
12Nicotine addiction_Homo sapiens_hsa050332.58010457
13Parkinsons disease_Homo sapiens_hsa050122.38261321
14Homologous recombination_Homo sapiens_hsa034402.29269007
15Nucleotide excision repair_Homo sapiens_hsa034202.24409363
16Oxidative phosphorylation_Homo sapiens_hsa001902.14872325
17Huntingtons disease_Homo sapiens_hsa050162.03148254
18Tryptophan metabolism_Homo sapiens_hsa003801.99747866
19Phototransduction_Homo sapiens_hsa047441.98481715
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98160622
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95042115
22Cell cycle_Homo sapiens_hsa041101.86270900
23Butanoate metabolism_Homo sapiens_hsa006501.85454619
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73364118
25Taste transduction_Homo sapiens_hsa047421.72241123
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65562045
27ABC transporters_Homo sapiens_hsa020101.64211588
28Sulfur relay system_Homo sapiens_hsa041221.58699208
29Protein export_Homo sapiens_hsa030601.56128740
30Purine metabolism_Homo sapiens_hsa002301.56066954
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54525929
32Lysine degradation_Homo sapiens_hsa003101.54124584
33Morphine addiction_Homo sapiens_hsa050321.52571545
34GABAergic synapse_Homo sapiens_hsa047271.46605937
35Fatty acid biosynthesis_Homo sapiens_hsa000611.45615187
36Alzheimers disease_Homo sapiens_hsa050101.44798761
37Cardiac muscle contraction_Homo sapiens_hsa042601.43951691
38Linoleic acid metabolism_Homo sapiens_hsa005911.43250418
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40451667
40beta-Alanine metabolism_Homo sapiens_hsa004101.40231558
41Folate biosynthesis_Homo sapiens_hsa007901.39575550
42Oocyte meiosis_Homo sapiens_hsa041141.38667919
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36697327
44Pentose phosphate pathway_Homo sapiens_hsa000301.36535057
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.35381188
46One carbon pool by folate_Homo sapiens_hsa006701.33980415
47Basal transcription factors_Homo sapiens_hsa030221.27364623
48RNA degradation_Homo sapiens_hsa030181.27071362
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25147339
50Nitrogen metabolism_Homo sapiens_hsa009101.20336247
51Propanoate metabolism_Homo sapiens_hsa006401.19657182
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19372626
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15519963
54Arginine and proline metabolism_Homo sapiens_hsa003301.15013944
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14162672
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09828517
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09462267
58Biosynthesis of amino acids_Homo sapiens_hsa012301.07503480
59mRNA surveillance pathway_Homo sapiens_hsa030151.07346163
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04890114
61Calcium signaling pathway_Homo sapiens_hsa040201.04852564
62Circadian entrainment_Homo sapiens_hsa047131.04710134
63Carbon metabolism_Homo sapiens_hsa012001.02576716
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99825645
65Fanconi anemia pathway_Homo sapiens_hsa034600.98676581
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98088058
67N-Glycan biosynthesis_Homo sapiens_hsa005100.95161334
68Epstein-Barr virus infection_Homo sapiens_hsa051690.93605315
69Ether lipid metabolism_Homo sapiens_hsa005650.91059802
70Serotonergic synapse_Homo sapiens_hsa047260.89573206
71Ovarian steroidogenesis_Homo sapiens_hsa049130.87142107
72Glutamatergic synapse_Homo sapiens_hsa047240.86858971
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86530595
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.86013537
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84739351
76Glycerolipid metabolism_Homo sapiens_hsa005610.84079809
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82941384
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80496025
79p53 signaling pathway_Homo sapiens_hsa041150.80376487
80Fructose and mannose metabolism_Homo sapiens_hsa000510.80286077
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.80117660
82Histidine metabolism_Homo sapiens_hsa003400.79186812
83Thyroid cancer_Homo sapiens_hsa052160.79015224
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77022596
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76942395
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71159135
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70535522
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68639715
89Fatty acid metabolism_Homo sapiens_hsa012120.68016626
90Arachidonic acid metabolism_Homo sapiens_hsa005900.67654871
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67027822
92Peroxisome_Homo sapiens_hsa041460.66777625
93Circadian rhythm_Homo sapiens_hsa047100.66211612
94Non-homologous end-joining_Homo sapiens_hsa034500.63353667
95Fat digestion and absorption_Homo sapiens_hsa049750.62719839
96Fatty acid degradation_Homo sapiens_hsa000710.61139861
97Type II diabetes mellitus_Homo sapiens_hsa049300.60704299
98Galactose metabolism_Homo sapiens_hsa000520.59655987
99Synaptic vesicle cycle_Homo sapiens_hsa047210.58806375
100Regulation of autophagy_Homo sapiens_hsa041400.56643546
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.56156513
102Alcoholism_Homo sapiens_hsa050340.55745749
103Steroid biosynthesis_Homo sapiens_hsa001000.55190222
104Selenocompound metabolism_Homo sapiens_hsa004500.54825561
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54786830
106Arginine biosynthesis_Homo sapiens_hsa002200.51714736
107Vitamin digestion and absorption_Homo sapiens_hsa049770.51536947
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50230512
109Shigellosis_Homo sapiens_hsa051310.50071614
110Pancreatic secretion_Homo sapiens_hsa049720.48950228
111Oxytocin signaling pathway_Homo sapiens_hsa049210.47800974
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.47043316
113Cholinergic synapse_Homo sapiens_hsa047250.45582856
114Bladder cancer_Homo sapiens_hsa052190.45137064
115Long-term depression_Homo sapiens_hsa047300.44586286
116Pyruvate metabolism_Homo sapiens_hsa006200.43693946
117Collecting duct acid secretion_Homo sapiens_hsa049660.43132985
118cAMP signaling pathway_Homo sapiens_hsa040240.42647442
119Systemic lupus erythematosus_Homo sapiens_hsa053220.41701627
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40600246
121Salivary secretion_Homo sapiens_hsa049700.40031406
122VEGF signaling pathway_Homo sapiens_hsa043700.39399534
123Legionellosis_Homo sapiens_hsa051340.39260923
124Metabolic pathways_Homo sapiens_hsa011000.38304719
125Viral carcinogenesis_Homo sapiens_hsa052030.38126412
126Vibrio cholerae infection_Homo sapiens_hsa051100.35324882
127Vitamin B6 metabolism_Homo sapiens_hsa007500.34497291
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33743705
129HTLV-I infection_Homo sapiens_hsa051660.32873958
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.32701299
131Antigen processing and presentation_Homo sapiens_hsa046120.30024150
132HIF-1 signaling pathway_Homo sapiens_hsa040660.28058985
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27305134
134Olfactory transduction_Homo sapiens_hsa047400.27092649
135Herpes simplex infection_Homo sapiens_hsa051680.25242361
136Long-term potentiation_Homo sapiens_hsa047200.25202099
137mTOR signaling pathway_Homo sapiens_hsa041500.24834941
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23530068
139Glutathione metabolism_Homo sapiens_hsa004800.23371765
140Acute myeloid leukemia_Homo sapiens_hsa052210.23215719
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22682470
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20739567
143Dopaminergic synapse_Homo sapiens_hsa047280.19482271
144Apoptosis_Homo sapiens_hsa042100.19433373
145Insulin signaling pathway_Homo sapiens_hsa049100.18498742
146Endocytosis_Homo sapiens_hsa041440.16818603
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15446181
148Renin-angiotensin system_Homo sapiens_hsa046140.12378228
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.09866881
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08945175
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08869718
152AMPK signaling pathway_Homo sapiens_hsa041520.08360817
153Glucagon signaling pathway_Homo sapiens_hsa049220.07798095
154Insulin secretion_Homo sapiens_hsa049110.07760331
155Other glycan degradation_Homo sapiens_hsa005110.07516624
156Gap junction_Homo sapiens_hsa045400.06888464
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06426793

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