MEF2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)4.61047304
2muscle filament sliding (GO:0030049)4.61047304
3sarcomere organization (GO:0045214)4.31699945
4* cardiac myofibril assembly (GO:0055003)4.22988999
5cardiac muscle contraction (GO:0060048)4.18507368
6actin-mediated cell contraction (GO:0070252)3.85551376
7regulation of actin filament-based movement (GO:1903115)3.71845542
8* cardiac muscle hypertrophy (GO:0003300)3.63640296
9striated muscle contraction (GO:0006941)3.55027453
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43954326
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43954326
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.43954326
13modulation by symbiont of host immune response (GO:0052553)3.43954326
14positive regulation by symbiont of host defense response (GO:0052509)3.43954326
15modulation by symbiont of host defense response (GO:0052031)3.43954326
16* striated muscle hypertrophy (GO:0014897)3.42124754
17actin filament-based movement (GO:0030048)3.38426946
18regulation of the force of heart contraction (GO:0002026)3.37892371
19cellular response to epinephrine stimulus (GO:0071872)3.24080689
20microglial cell activation (GO:0001774)3.13544936
21* muscle hypertrophy (GO:0014896)3.11480916
22* actomyosin structure organization (GO:0031032)3.07021852
23negative regulation of myotube differentiation (GO:0010832)3.02530420
24macrophage activation involved in immune response (GO:0002281)3.01382583
25cardiac muscle tissue morphogenesis (GO:0055008)2.92132128
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91400652
27response to epinephrine (GO:0071871)2.89213028
28regulation of interferon-beta biosynthetic process (GO:0045357)2.87144382
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85538890
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.83074683
31plasma membrane repair (GO:0001778)2.82224910
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.82010181
33skeletal muscle contraction (GO:0003009)2.81626231
34regulation of skeletal muscle cell differentiation (GO:2001014)2.80661049
35regulation of cardiac muscle cell contraction (GO:0086004)2.78142856
36response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.76463989
37relaxation of cardiac muscle (GO:0055119)2.74806648
38negative regulation of cell killing (GO:0031342)2.74620126
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74620126
40sarcoplasmic reticulum calcium ion transport (GO:0070296)2.70516804
41adult heart development (GO:0007512)2.69817531
42cardiac muscle cell development (GO:0055013)2.69769986
43muscle tissue morphogenesis (GO:0060415)2.69173961
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.68829223
45regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64931162
46positive regulation of gamma-delta T cell activation (GO:0046645)2.60708234
47regulation of cell communication by electrical coupling (GO:0010649)2.60391127
48carnitine shuttle (GO:0006853)2.59547232
49cardiac cell development (GO:0055006)2.58728542
50ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.53584902
51I-kappaB phosphorylation (GO:0007252)2.52790742
52regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.52669514
53regulation of synapse structural plasticity (GO:0051823)2.50536694
54G-protein coupled receptor internalization (GO:0002031)2.49935854
55response to inactivity (GO:0014854)2.47023161
56cellular response to ethanol (GO:0071361)2.44345736
57response to host immune response (GO:0052572)2.43964819
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43964819
59positive regulation of receptor recycling (GO:0001921)2.43849143
60negative regulation of erythrocyte differentiation (GO:0045647)2.43827607
61* cardiac muscle adaptation (GO:0014887)2.42377368
62* cardiac muscle hypertrophy in response to stress (GO:0014898)2.42377368
63* muscle hypertrophy in response to stress (GO:0003299)2.42377368
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.41733507
65negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.39944707
66negative regulation of granulocyte differentiation (GO:0030853)2.39149599
67regulation of cardioblast differentiation (GO:0051890)2.36555009
68muscle contraction (GO:0006936)2.36439481
69cellular response to thyroid hormone stimulus (GO:0097067)2.35777360
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.34789525
71macrophage activation (GO:0042116)2.34697005
72response to host (GO:0075136)2.33205527
73response to host defenses (GO:0052200)2.33205527
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33205527
75synaptic vesicle maturation (GO:0016188)2.33040246
76positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.31061896
77bundle of His cell to Purkinje myocyte communication (GO:0086069)2.30629445
78positive regulation of cellular amide metabolic process (GO:0034250)2.30242766
79sodium ion export (GO:0071436)2.29883676
80cell adhesion mediated by integrin (GO:0033627)2.29493918
81clathrin coat assembly (GO:0048268)2.28897869
82detection of molecule of bacterial origin (GO:0032490)2.25470279
83regulation of macrophage cytokine production (GO:0010935)2.25335416
84* striated muscle adaptation (GO:0014888)2.25155532
85positive regulation of myotube differentiation (GO:0010831)2.24743173
86neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.23792130
87* muscle system process (GO:0003012)2.22583269
88ventricular cardiac muscle cell action potential (GO:0086005)2.21868031
89nerve growth factor signaling pathway (GO:0038180)2.21807421
90regulation of short-term neuronal synaptic plasticity (GO:0048172)2.20331760
91skeletal muscle adaptation (GO:0043501)2.20298229
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.20137647
93* regulation of heart contraction (GO:0008016)2.19514824
94detection of calcium ion (GO:0005513)2.18708267
95cerebellar Purkinje cell differentiation (GO:0021702)2.18259945
96negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.17168620
97regulation of gamma-delta T cell activation (GO:0046643)2.17127177
98locomotory exploration behavior (GO:0035641)2.16508757
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.16338342
100activation of protein kinase A activity (GO:0034199)2.16253057
101* regulation of muscle system process (GO:0090257)2.16216976
102substrate-dependent cell migration (GO:0006929)2.16117745
103regulation of calcium ion transmembrane transporter activity (GO:1901019)2.13822041
104regulation of calcium ion transmembrane transport (GO:1903169)2.13822041
105vesicle transport along microtubule (GO:0047496)2.13598422
106fatty acid transmembrane transport (GO:1902001)2.13568942
107venous blood vessel morphogenesis (GO:0048845)2.12699106
108* cardiac chamber formation (GO:0003207)2.11656550
109membrane depolarization during action potential (GO:0086010)2.11625785
110regulation of T-helper 2 cell differentiation (GO:0045628)2.11451094
111response to peptidoglycan (GO:0032494)2.10846298
112regulation of heart rate (GO:0002027)2.10060916
113cardiac muscle cell proliferation (GO:0060038)2.09152671
114positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.08263624
115regulation of ARF protein signal transduction (GO:0032012)2.07879786
116positive regulation of fibroblast migration (GO:0010763)2.06882145
117regulation of membrane repolarization (GO:0060306)2.05683974
118negative regulation of potassium ion transmembrane transport (GO:1901380)2.02944523
119regulation of B cell receptor signaling pathway (GO:0050855)2.02553589
120cellular potassium ion homeostasis (GO:0030007)2.01949239
121positive regulation of macrophage cytokine production (GO:0060907)1.97988666
122protein localization to endosome (GO:0036010)1.97625163
123striated muscle atrophy (GO:0014891)1.97051953
124relaxation of muscle (GO:0090075)1.97034734
125positive regulation of cation channel activity (GO:2001259)1.94661284
126regulation of Rap GTPase activity (GO:0032317)1.93648540
127regulation of translation, ncRNA-mediated (GO:0045974)1.92294804
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.92294804
129negative regulation of translation, ncRNA-mediated (GO:0040033)1.92294804
130potassium ion import (GO:0010107)1.91918590
131regulation of skeletal muscle contraction (GO:0014819)1.91773438
132regulation of striated muscle contraction (GO:0006942)1.91473744
133positive regulation of myoblast differentiation (GO:0045663)1.91011700
134synaptic vesicle endocytosis (GO:0048488)1.90784758
135glutamate receptor signaling pathway (GO:0007215)1.90411488
136* myofibril assembly (GO:0030239)1.89034118
137regulation of relaxation of muscle (GO:1901077)1.88565471
138cell communication involved in cardiac conduction (GO:0086065)1.88365978
139phosphatidylinositol dephosphorylation (GO:0046856)1.87902017
140response to muramyl dipeptide (GO:0032495)1.87770884
141vocalization behavior (GO:0071625)1.87669725
142cell communication by electrical coupling (GO:0010644)1.87032182
143positive regulation of Rap GTPase activity (GO:0032854)1.86369773
144neutrophil mediated immunity (GO:0002446)1.86367761
145myeloid cell activation involved in immune response (GO:0002275)1.85835275
146cytoplasmic mRNA processing body assembly (GO:0033962)1.85790490
147muscle atrophy (GO:0014889)1.85281587
148regulation of cation channel activity (GO:2001257)1.84050502
149* regulation of glutamate receptor signaling pathway (GO:1900449)1.84026080
150L-amino acid import (GO:0043092)1.83896901
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.83543017
152negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.83455081
153membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.82704822
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.82363952
155regulation of p38MAPK cascade (GO:1900744)1.82065635
156regulation of cardiac muscle contraction (GO:0055117)1.82053654
157retrograde transport, vesicle recycling within Golgi (GO:0000301)1.82031392
158* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.81502051
159neuron projection extension involved in neuron projection guidance (GO:1902284)1.81147150
160axon extension involved in axon guidance (GO:0048846)1.81147150
161* cardiac conduction (GO:0061337)1.81032672
162regulation of ARF GTPase activity (GO:0032312)1.80899651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.61410669
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.33104148
3EZH2_22144423_ChIP-Seq_EOC_Human2.26946275
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12430791
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03969957
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86896082
7BP1_19119308_ChIP-ChIP_Hs578T_Human1.84924267
8DROSHA_22980978_ChIP-Seq_HELA_Human1.84251286
9ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81645431
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80692021
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80362935
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78441538
13* TBX20_22328084_ChIP-Seq_HEART_Mouse1.78246027
14* TBX20_22080862_ChIP-Seq_HEART_Mouse1.78246027
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77128465
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75335924
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74874054
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68640385
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64410511
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.64347012
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64177635
22AR_21572438_ChIP-Seq_LNCaP_Human1.63484917
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61892394
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61892394
25TP53_16413492_ChIP-PET_HCT116_Human1.55539767
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55458312
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54538856
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54278764
29* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53248305
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52737919
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.50934075
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.48497653
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46394104
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42415393
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41646977
36* AHR_22903824_ChIP-Seq_MCF-7_Human1.41621130
37SMAD4_21799915_ChIP-Seq_A2780_Human1.40472689
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39879793
39* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38222378
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.36753352
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35300501
42VDR_24787735_ChIP-Seq_THP-1_Human1.34480205
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34445238
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.34224005
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31679701
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.31602173
47SCL_19346495_ChIP-Seq_HPC-7_Human1.30182346
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29925296
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29137971
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28726686
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.27938643
52* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27897277
53* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25921916
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.24515553
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23708540
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.23140819
57TP53_18474530_ChIP-ChIP_U2OS_Human1.22162978
58P300_19829295_ChIP-Seq_ESCs_Human1.21281366
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20129375
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.19469736
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19357216
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18295335
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18274617
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18169536
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17249728
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16971072
67* CLOCK_20551151_ChIP-Seq_293T_Human1.16724238
68RUNX_20019798_ChIP-Seq_JUKART_Human1.16385812
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15444951
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15078990
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.14693904
72CJUN_26792858_Chip-Seq_BT549_Human1.14157434
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13769301
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13769301
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13625203
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12996399
77RXR_22108803_ChIP-Seq_LS180_Human1.12887583
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.12706217
79* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12321733
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09690009
81* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09653083
82* STAT3_23295773_ChIP-Seq_U87_Human1.08944128
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08603536
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08175955
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08153338
86* TCF7_22412390_ChIP-Seq_EML_Mouse1.07386866
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07264997
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07260269
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.07233478
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07168193
91* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07009300
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.06317567
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.06163222
94SPI1_23127762_ChIP-Seq_K562_Human1.06135677
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.05271879
96AR_25329375_ChIP-Seq_VCAP_Human1.05253301
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05138817
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04886302
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.04531440
100TAF15_26573619_Chip-Seq_HEK293_Human1.03961795
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.03027144
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01714229
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01636285
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.00930677
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00194187
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00163573
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99186942
108TCF4_23295773_ChIP-Seq_U87_Human0.98968365
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98473992
110SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98360514
111GATA1_19941826_ChIP-Seq_K562_Human0.98193547
112IRF8_22096565_ChIP-ChIP_GC-B_Human0.96688761
113BCAT_22108803_ChIP-Seq_LS180_Human0.96639605
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96455663
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.96001976
116PU_27001747_Chip-Seq_BMDM_Mouse0.95474839
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95394926
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95223617
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95095716
120BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94839451
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94500794
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94395549
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.93590992
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.93462071
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92625551
126GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92180674
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91742561
128LXR_22158963_ChIP-Seq_LIVER_Mouse0.91717609
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.91460663
130VDR_24763502_ChIP-Seq_THP-1_Human0.91324087
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91289388
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.90905284
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90780132
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90780132
135* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90287796
136KDM2B_26808549_Chip-Seq_DND41_Human0.90198198
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89625325
138GATA1_22025678_ChIP-Seq_K562_Human0.89608461
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89018623
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88816358
141* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86766819
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86435940
143* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84730764
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.83798859
145GATA2_19941826_ChIP-Seq_K562_Human0.83527172
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81881175
147* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81271248
148* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81271248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.77223197
2MP0004859_abnormal_synaptic_plasticity3.25277080
3MP0004510_myositis2.89494998
4MP0000751_myopathy2.49035053
5MP0003828_pulmonary_edema2.30758135
6MP0004084_abnormal_cardiac_muscle2.07881123
7MP0004484_altered_response_of2.03342871
8MP0003172_abnormal_lysosome_physiology1.98879581
9MP0005167_abnormal_blood-brain_barrier1.87817263
10MP0004270_analgesia1.77328570
11MP0003045_fibrosis1.77266967
12MP0003635_abnormal_synaptic_transmissio1.75390292
13MP0004215_abnormal_myocardial_fiber1.74700801
14MP0009780_abnormal_chondrocyte_physiolo1.67509589
15MP0005058_abnormal_lysosome_morphology1.67328002
16MP0000749_muscle_degeneration1.67318736
17MP0009046_muscle_twitch1.66686365
18MP0004130_abnormal_muscle_cell1.64892881
19MP0004036_abnormal_muscle_relaxation1.63087256
20MP0004145_abnormal_muscle_electrophysio1.61758999
21MP0002009_preneoplasia1.60305130
22MP0003300_gastrointestinal_ulcer1.59959235
23MP0003724_increased_susceptibility_to1.57640641
24MP0002837_dystrophic_cardiac_calcinosis1.55217894
25MP0003191_abnormal_cellular_cholesterol1.52350242
26MP0002972_abnormal_cardiac_muscle1.52142352
27MP0003303_peritoneal_inflammation1.51100589
28MP0002269_muscular_atrophy1.50169973
29MP0001879_abnormal_lymphatic_vessel1.48264184
30MP0005275_abnormal_skin_tensile1.47436681
31MP0000015_abnormal_ear_pigmentation1.47366974
32MP0005409_darkened_coat_color1.44395969
33MP0005174_abnormal_tail_pigmentation1.42656225
34MP0009745_abnormal_behavioral_response1.42456574
35MP0005451_abnormal_body_composition1.41178097
36MP0003183_abnormal_peptide_metabolism1.40079097
37MP0003950_abnormal_plasma_membrane1.37356493
38MP0000685_abnormal_immune_system1.37213592
39MP0004087_abnormal_muscle_fiber1.34904903
40MP0002064_seizures1.34221425
41MP0003787_abnormal_imprinting1.33636194
42MP0002063_abnormal_learning/memory/cond1.32668604
43MP0003279_aneurysm1.30782812
44MP0002998_abnormal_bone_remodeling1.30325644
45MP0003091_abnormal_cell_migration1.30272025
46MP0005387_immune_system_phenotype1.28965377
47MP0001790_abnormal_immune_system1.28965377
48MP0005620_abnormal_muscle_contractility1.27945225
49MP0003705_abnormal_hypodermis_morpholog1.27308549
50MP0003880_abnormal_central_pattern1.25780558
51MP0002971_abnormal_brown_adipose1.23593524
52MP0005165_increased_susceptibility_to1.22726587
53MP0002127_abnormal_cardiovascular_syste1.22453263
54MP0000767_abnormal_smooth_muscle1.22041316
55MP0003690_abnormal_glial_cell1.21582056
56MP0002877_abnormal_melanocyte_morpholog1.19588038
57MP0002106_abnormal_muscle_physiology1.19170549
58MP0005623_abnormal_meninges_morphology1.18825296
59MP0009278_abnormal_bone_marrow1.16098734
60MP0005670_abnormal_white_adipose1.15249473
61MP0010630_abnormal_cardiac_muscle1.15029971
62MP0003566_abnormal_cell_adhesion1.14974921
63MP0002419_abnormal_innate_immunity1.14440977
64MP0002254_reproductive_system_inflammat1.13728122
65MP0008775_abnormal_heart_ventricle1.12651165
66MP0005666_abnormal_adipose_tissue1.12615563
67MP0001958_emphysema1.11680993
68MP0001486_abnormal_startle_reflex1.10686187
69MP0004233_abnormal_muscle_weight1.09375025
70MP0010368_abnormal_lymphatic_system1.06966201
71MP0001851_eye_inflammation1.06621125
72MP0000733_abnormal_muscle_development1.06601516
73MP0003075_altered_response_to1.05269048
74MP0005330_cardiomyopathy1.03723872
75MP0005369_muscle_phenotype1.03160542
76MP0002572_abnormal_emotion/affect_behav1.03115107
77MP0003633_abnormal_nervous_system1.02957719
78MP0005375_adipose_tissue_phenotype1.02549115
79MP0002166_altered_tumor_susceptibility1.00519937
80MP0005000_abnormal_immune_tolerance1.00470658
81MP0001835_abnormal_antigen_presentation1.00415110
82MP0003137_abnormal_impulse_conducting0.99648394
83MP0001299_abnormal_eye_distance/0.99134466
84MP0003763_abnormal_thymus_physiology0.97785059
85* MP0004085_abnormal_heartbeat0.96545304
86MP0001968_abnormal_touch/_nociception0.96395769
87MP0000750_abnormal_muscle_regeneration0.95050405
88MP0001661_extended_life_span0.93802028
89MP0000747_muscle_weakness0.93390978
90MP0002090_abnormal_vision0.93158584
91MP0001800_abnormal_humoral_immune0.92632071
92MP0001501_abnormal_sleep_pattern0.92554331
93MP0002909_abnormal_adrenal_gland0.92379750
94MP0005171_absent_coat_pigmentation0.91996799
95MP0000604_amyloidosis0.91764407
96MP0002108_abnormal_muscle_morphology0.90527377
97MP0001533_abnormal_skeleton_physiology0.90233902
98MP0000759_abnormal_skeletal_muscle0.90215320
99MP0000383_abnormal_hair_follicle0.89430275
100MP0006082_CNS_inflammation0.88899310
101MP0001440_abnormal_grooming_behavior0.88792820
102MP0002067_abnormal_sensory_capabilities0.88784314
103MP0000343_altered_response_to0.88594477
104MP0002735_abnormal_chemical_nociception0.88064335
105MP0005464_abnormal_platelet_physiology0.87973991
106MP0005385_cardiovascular_system_phenoty0.87797772
107MP0001544_abnormal_cardiovascular_syste0.87797772
108MP0008438_abnormal_cutaneous_collagen0.87574507
109MP0008569_lethality_at_weaning0.86907832
110MP0008004_abnormal_stomach_pH0.86851916
111MP0003646_muscle_fatigue0.85148053
112MP0002734_abnormal_mechanical_nocicepti0.84862066
113MP0010678_abnormal_skin_adnexa0.82828594
114MP0002452_abnormal_antigen_presenting0.82651004
115MP0009785_altered_susceptibility_to0.81266040
116MP0003436_decreased_susceptibility_to0.80596308
117MP0003221_abnormal_cardiomyocyte_apopto0.80099166
118MP0003329_amyloid_beta_deposits0.78677280
119MP0006138_congestive_heart_failure0.78048417
120MP0001188_hyperpigmentation0.77984651
121MP0002723_abnormal_immune_serum0.77525245
122MP0000003_abnormal_adipose_tissue0.77451034
123MP0004947_skin_inflammation0.77450891
124MP0000920_abnormal_myelination0.77264315
125MP0004272_abnormal_basement_membrane0.76470124
126MP0009115_abnormal_fat_cell0.75971543
127MP0002928_abnormal_bile_duct0.75906994
128MP0008961_abnormal_basal_metabolism0.75783117
129MP0000249_abnormal_blood_vessel0.75651093
130MP0005503_abnormal_tendon_morphology0.75624790
131MP0005166_decreased_susceptibility_to0.74787946
132MP0005388_respiratory_system_phenotype0.74554035
133MP0002133_abnormal_respiratory_system0.74554035
134MP0002006_tumorigenesis0.73772012
135MP0002896_abnormal_bone_mineralization0.72965292
136MP0005025_abnormal_response_to0.72468384
137MP0002332_abnormal_exercise_endurance0.72368561
138MP0000013_abnormal_adipose_tissue0.72160519
139MP0002148_abnormal_hypersensitivity_rea0.72090712

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.10675740
2Distal lower limb amyotrophy (HP:0008944)3.49073158
3Lower limb amyotrophy (HP:0007210)3.38552132
4Hypoplastic ischia (HP:0003175)3.37952996
5Heart block (HP:0012722)3.19874600
6Sudden death (HP:0001699)3.17746191
7Abnormal atrioventricular conduction (HP:0005150)3.09500160
8Centrally nucleated skeletal muscle fibers (HP:0003687)3.04669570
9Ventricular arrhythmia (HP:0004308)2.99404701
10Papilledema (HP:0001085)2.99231413
11Abnormality of the ischium (HP:0003174)2.99159064
12Lipoatrophy (HP:0100578)2.99022779
13Focal motor seizures (HP:0011153)2.97991861
14Right ventricular cardiomyopathy (HP:0011663)2.95607773
15Thick nail (HP:0001805)2.88380993
16Arterial tortuosity (HP:0005116)2.86709692
17Febrile seizures (HP:0002373)2.84372359
18Spontaneous hematomas (HP:0007420)2.79049464
19Facial diplegia (HP:0001349)2.77313055
20Atrioventricular block (HP:0001678)2.73869578
21Hyporeflexia of lower limbs (HP:0002600)2.72597983
22Hematochezia (HP:0002573)2.72403140
23Absent frontal sinuses (HP:0002688)2.71671506
24Neck muscle weakness (HP:0000467)2.70715404
25Distal lower limb muscle weakness (HP:0009053)2.68054727
26Recurrent abscess formation (HP:0002722)2.64621310
27Atrial fibrillation (HP:0005110)2.64050840
28Increased cerebral lipofuscin (HP:0011813)2.61344316
29Abnormality of the calf musculature (HP:0001430)2.60136745
30Cerebral aneurysm (HP:0004944)2.57402782
31Dilated cardiomyopathy (HP:0001644)2.57164919
32Round ear (HP:0100830)2.54270401
33Calf muscle hypertrophy (HP:0008981)2.53548042
34Vascular tortuosity (HP:0004948)2.51598222
35EMG: neuropathic changes (HP:0003445)2.51494421
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50333508
37Primary atrial arrhythmia (HP:0001692)2.46403407
38EMG: myopathic abnormalities (HP:0003458)2.45485670
39Exercise-induced myalgia (HP:0003738)2.41011916
40Syncope (HP:0001279)2.40569412
41Focal seizures (HP:0007359)2.40505670
42Muscle fiber splitting (HP:0003555)2.38849047
43Ventricular fibrillation (HP:0001663)2.37780351
44Recurrent bacterial skin infections (HP:0005406)2.37664350
45Muscle hypertrophy of the lower extremities (HP:0008968)2.33695106
46Difficulty running (HP:0009046)2.30800915
47Prolonged QT interval (HP:0001657)2.29314101
48Spondylolisthesis (HP:0003302)2.25153125
49Type 1 muscle fiber predominance (HP:0003803)2.23276084
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23100150
51Ulnar deviation of the wrist (HP:0003049)2.21788631
52Rhabdomyolysis (HP:0003201)2.21184354
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.19069725
54Distal arthrogryposis (HP:0005684)2.18883211
55Supraventricular tachycardia (HP:0004755)2.17676437
56Myoglobinuria (HP:0002913)2.17213177
57Mutism (HP:0002300)2.16412504
58Inappropriate behavior (HP:0000719)2.16240910
59Supraventricular arrhythmia (HP:0005115)2.15481017
60Overgrowth (HP:0001548)2.13475572
61Exotropia (HP:0000577)2.12878128
62Fetal akinesia sequence (HP:0001989)2.11354536
63Prostate neoplasm (HP:0100787)2.10421301
64Aortic aneurysm (HP:0004942)2.10205159
65Abnormality of the frontal sinuses (HP:0002687)2.09374188
66Urethral obstruction (HP:0000796)2.08386585
67Genetic anticipation (HP:0003743)2.08005006
68Abnormality of the foot musculature (HP:0001436)2.05072056
69Progressive cerebellar ataxia (HP:0002073)2.04447934
70Frequent falls (HP:0002359)2.03104805
71Mildly elevated creatine phosphokinase (HP:0008180)2.02139438
72Abnormality of liposaccharide metabolism (HP:0010968)2.01355323
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.01355323
74Abnormality of glycolipid metabolism (HP:0010969)2.01355323
75Increased connective tissue (HP:0009025)2.00690033
76Action tremor (HP:0002345)1.99690057
77Foot dorsiflexor weakness (HP:0009027)1.99516923
78Sudden cardiac death (HP:0001645)1.98025448
79Abnormality of the endocardium (HP:0004306)1.96661537
80Hip contracture (HP:0003273)1.96397368
81Obstructive sleep apnea (HP:0002870)1.96186080
82Submucous cleft hard palate (HP:0000176)1.95561138
83Epiphyseal dysplasia (HP:0002656)1.94968189
84Axonal loss (HP:0003447)1.93722602
85Limited hip movement (HP:0008800)1.92541818
86Scapular winging (HP:0003691)1.92166249
87Disinhibition (HP:0000734)1.91249521
88Dysostosis multiplex (HP:0000943)1.89681456
89Asymmetric septal hypertrophy (HP:0001670)1.88833110
90Aneurysm (HP:0002617)1.88402468
91Eczematoid dermatitis (HP:0000976)1.88299424
92Excessive salivation (HP:0003781)1.86732001
93Drooling (HP:0002307)1.86732001
94Systemic lupus erythematosus (HP:0002725)1.86496381
95Pulmonary artery stenosis (HP:0004415)1.84797586
96Progressive inability to walk (HP:0002505)1.82131543
97Abnormality of the left ventricular outflow tract (HP:0011103)1.81764120
98Subaortic stenosis (HP:0001682)1.81764120
99Areflexia of lower limbs (HP:0002522)1.81381824
100Supranuclear gaze palsy (HP:0000605)1.81262406
101Palpitations (HP:0001962)1.81210887
102Widely spaced teeth (HP:0000687)1.80053381
103Absent speech (HP:0001344)1.79790118
104Gaze-evoked nystagmus (HP:0000640)1.78875524
105Steppage gait (HP:0003376)1.78770296
106Epileptic encephalopathy (HP:0200134)1.78727570
107Aortic dissection (HP:0002647)1.77555355
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77258958
109Hyperkalemia (HP:0002153)1.77001754
110Mask-like facies (HP:0000298)1.76285344
111Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76126502
112Urinary bladder sphincter dysfunction (HP:0002839)1.76091748
113Abnormal EKG (HP:0003115)1.74747463
114Broad metatarsal (HP:0001783)1.74645354
115Mitral valve prolapse (HP:0001634)1.74640027
116Generalized muscle weakness (HP:0003324)1.73879468
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.73113116
118Osteolytic defects of the hand bones (HP:0009699)1.73113116
119Dysmetric saccades (HP:0000641)1.72846283
120Exercise-induced muscle cramps (HP:0003710)1.72738292
121Gingivitis (HP:0000230)1.71520605
122Abnormality of skeletal muscle fiber size (HP:0012084)1.68612759
123Gowers sign (HP:0003391)1.68376454
124Macroorchidism (HP:0000053)1.68175516
125Muscle fiber inclusion bodies (HP:0100299)1.68156950
126Visual hallucinations (HP:0002367)1.67904161
127Atonic seizures (HP:0010819)1.67318841
128Broad-based gait (HP:0002136)1.67242857
129Increased variability in muscle fiber diameter (HP:0003557)1.67161693
130Metaphyseal dysplasia (HP:0100255)1.66195904
131Narrow palate (HP:0000189)1.66187188
132Bundle branch block (HP:0011710)1.64805195
133Persistence of primary teeth (HP:0006335)1.63969356
134Striae distensae (HP:0001065)1.62958215
135Onion bulb formation (HP:0003383)1.62235397
136Recurrent gram-negative bacterial infections (HP:0005420)1.61572440
137Abnormality of the right ventricle (HP:0001707)1.60674700
138Generalized tonic-clonic seizures (HP:0002069)1.60578459
139Ventricular tachycardia (HP:0004756)1.60572417
140Abnormality of the nasal septum (HP:0000419)1.60474092
141Rimmed vacuoles (HP:0003805)1.60235176
142Lower limb asymmetry (HP:0100559)1.60083838
143Esophageal varix (HP:0002040)1.59938919
144Rapidly progressive (HP:0003678)1.59897186
145Gastrointestinal stroma tumor (HP:0100723)1.59745804
146Dilatation of the ascending aorta (HP:0005111)1.59573281
147Bulbar palsy (HP:0001283)1.53969199
148Urinary glycosaminoglycan excretion (HP:0003541)1.53335730
149Mucopolysacchariduria (HP:0008155)1.53335730
150Fatigue (HP:0012378)1.52516081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.28141839
2TGFBR22.92654690
3CAMK1G2.30213315
4CAMK1D2.20800940
5DMPK2.08569775
6NEK92.06246363
7EPHA41.98629168
8MYLK1.93394698
9BLK1.91190690
10PKN21.87803404
11GRK71.85190912
12SIK21.83498857
13TTN1.83208770
14RIPK11.78327505
15NTRK31.74971638
16INSRR1.65881512
17MAP3K131.60863619
18DAPK21.55305751
19MAP2K31.52461639
20CDC42BPA1.47587795
21CAMKK21.44922061
22MAP3K91.44017542
23MAP3K141.43887374
24ERN11.34049456
25JAK11.32217839
26PTK2B1.29479644
27SGK21.26424686
28FES1.23491018
29SGK31.22948337
30CAMKK11.22774908
31SYK1.11758270
32MAP3K41.11177228
33PLK21.09870682
34PDGFRA1.09682449
35PIK3CA1.08439972
36WNK11.06433724
37PRPF4B1.04724462
38PHKG21.02198730
39PHKG11.02198730
40OBSCN1.02111251
41STK241.00935506
42FGFR30.99909595
43MAP3K100.98453976
44HCK0.97974190
45FGFR20.97042379
46CAMK40.96627018
47ZAP700.96261060
48SGK10.95419424
49KIT0.94651875
50MOS0.94407260
51* MAPK70.92694876
52JAK30.92231200
53MAP3K70.91516340
54CSF1R0.90420414
55CSK0.88594181
56PDGFRB0.87111705
57TIE10.86764143
58NLK0.85292857
59BMPR20.85282121
60CAMK10.85095761
61CDK120.84976781
62PRKCH0.84333511
63TRPM70.81672404
64PDK10.81560212
65JAK20.81042066
66MAP3K60.79879607
67EEF2K0.79550148
68AKT30.75959570
69TYK20.75757379
70MAP3K20.75668114
71PAK60.74827411
72SGK4940.73309977
73SGK2230.73309977
74PDPK10.73135834
75MAP3K10.72924529
76TRIB30.71509951
77PTK60.70657454
78PRKCE0.70457643
79MUSK0.70158153
80NUAK10.70017792
81FRK0.69525130
82STK380.69246953
83PRKAA20.68797433
84TAOK30.67738423
85PDK20.66694296
86STK110.65843204
87ITK0.65837947
88* CDK50.65054573
89PRKD10.64915412
90MAP2K40.64667544
91RET0.63275596
92ERBB30.63051935
93MAP3K30.62961663
94FER0.62783539
95GRK50.62592340
96FLT30.62468886
97PKN10.62088502
98FGR0.61871848
99KSR20.61377380
100MAP2K70.60646482
101SIK30.60562355
102MINK10.60144887
103TBK10.60078564
104MAPK40.59918568
105MAP3K50.59324131
106MAPK150.57457341
107FGFR40.56771121
108LMTK20.56380363
109FYN0.56104090
110EPHB10.54948247
111LATS20.54794709
112PAK30.54492789
113IRAK30.54272427
114CAMK2A0.54212399
115PRKCQ0.54125661
116NTRK10.53974317
117STK38L0.53904141
118NTRK20.53292148
119MARK20.53063323
120IKBKE0.52977735
121DDR20.51539173
122PIK3CG0.50873572
123MARK30.50655164
124BTK0.49244904
125* MAPK120.49219286
126MAPKAPK30.49092691
127MAP4K10.48989288
128EGFR0.48957048
129NEK60.48338589
130MARK10.47782667
131PRKAA10.46779766
132TXK0.46770408
133CDK60.46311174
134EPHA30.44879071
135ICK0.44792868
136HIPK20.43538451
137RPS6KA20.42518166
138ROCK10.42444112
139KSR10.41923112
140MAPK110.40508298
141MAP2K10.39008104

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047101.72644071
2Olfactory transduction_Homo sapiens_hsa047401.72183629
3Dilated cardiomyopathy_Homo sapiens_hsa054141.63398682
4Circadian entrainment_Homo sapiens_hsa047131.48003710
5Osteoclast differentiation_Homo sapiens_hsa043801.46877434
6Renin secretion_Homo sapiens_hsa049241.46100324
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42133682
8Long-term potentiation_Homo sapiens_hsa047201.39843506
9Morphine addiction_Homo sapiens_hsa050321.38712997
10Oxytocin signaling pathway_Homo sapiens_hsa049211.37141038
11Nicotine addiction_Homo sapiens_hsa050331.33816948
12Type II diabetes mellitus_Homo sapiens_hsa049301.32565201
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30428157
14Glutamatergic synapse_Homo sapiens_hsa047241.30298574
15Salivary secretion_Homo sapiens_hsa049701.29769587
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29618477
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28774763
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24110992
19Calcium signaling pathway_Homo sapiens_hsa040201.22040781
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22037211
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21184098
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21125952
23Cholinergic synapse_Homo sapiens_hsa047251.20089301
24Gastric acid secretion_Homo sapiens_hsa049711.16954205
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15706422
26B cell receptor signaling pathway_Homo sapiens_hsa046621.14623933
27GnRH signaling pathway_Homo sapiens_hsa049121.14122545
28Amphetamine addiction_Homo sapiens_hsa050311.13240179
29Dorso-ventral axis formation_Homo sapiens_hsa043201.12186203
30cAMP signaling pathway_Homo sapiens_hsa040241.10198875
31Synaptic vesicle cycle_Homo sapiens_hsa047211.10091126
32* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09120850
33GABAergic synapse_Homo sapiens_hsa047271.09043989
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08561593
35Other glycan degradation_Homo sapiens_hsa005111.04541342
36Leishmaniasis_Homo sapiens_hsa051401.04228996
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04167821
38Dopaminergic synapse_Homo sapiens_hsa047281.02105036
39Glioma_Homo sapiens_hsa052141.00979919
40Tuberculosis_Homo sapiens_hsa051521.00805363
41Insulin secretion_Homo sapiens_hsa049110.99756601
42Focal adhesion_Homo sapiens_hsa045100.99541538
43Insulin signaling pathway_Homo sapiens_hsa049100.98305731
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97802864
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96312385
46Long-term depression_Homo sapiens_hsa047300.95043586
47Staphylococcus aureus infection_Homo sapiens_hsa051500.94942916
48Chemokine signaling pathway_Homo sapiens_hsa040620.94490599
49Platelet activation_Homo sapiens_hsa046110.94410616
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93922785
51ECM-receptor interaction_Homo sapiens_hsa045120.93554756
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93156896
53Estrogen signaling pathway_Homo sapiens_hsa049150.92174816
54Taste transduction_Homo sapiens_hsa047420.91995975
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.91931325
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90806506
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89371330
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.88435241
59Amoebiasis_Homo sapiens_hsa051460.87374988
60Axon guidance_Homo sapiens_hsa043600.87166890
61Acute myeloid leukemia_Homo sapiens_hsa052210.87092986
62ErbB signaling pathway_Homo sapiens_hsa040120.85816420
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.85735520
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.85169042
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84803973
66Toxoplasmosis_Homo sapiens_hsa051450.84428035
67Serotonergic synapse_Homo sapiens_hsa047260.84399715
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84110349
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.83997154
70Lysosome_Homo sapiens_hsa041420.83625893
71Pertussis_Homo sapiens_hsa051330.83397473
72Rheumatoid arthritis_Homo sapiens_hsa053230.83244340
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83115030
74MAPK signaling pathway_Homo sapiens_hsa040100.82765744
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82578448
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81741204
77TNF signaling pathway_Homo sapiens_hsa046680.81482054
78Rap1 signaling pathway_Homo sapiens_hsa040150.81099280
79Malaria_Homo sapiens_hsa051440.80961906
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80720889
81mTOR signaling pathway_Homo sapiens_hsa041500.79557741
82African trypanosomiasis_Homo sapiens_hsa051430.79359555
83Cocaine addiction_Homo sapiens_hsa050300.78775158
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78625698
85FoxO signaling pathway_Homo sapiens_hsa040680.78192416
86Allograft rejection_Homo sapiens_hsa053300.77727389
87Choline metabolism in cancer_Homo sapiens_hsa052310.77679360
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.77372031
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77195015
90Proteoglycans in cancer_Homo sapiens_hsa052050.77039474
91Non-small cell lung cancer_Homo sapiens_hsa052230.76707561
92Glucagon signaling pathway_Homo sapiens_hsa049220.76438392
93Salmonella infection_Homo sapiens_hsa051320.75954339
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.75477147
95Adherens junction_Homo sapiens_hsa045200.75263480
96VEGF signaling pathway_Homo sapiens_hsa043700.75193044
97Chronic myeloid leukemia_Homo sapiens_hsa052200.74091341
98Renal cell carcinoma_Homo sapiens_hsa052110.73820214
99Prion diseases_Homo sapiens_hsa050200.73580927
100Inositol phosphate metabolism_Homo sapiens_hsa005620.72857333
101Phagosome_Homo sapiens_hsa041450.72795239
102Gap junction_Homo sapiens_hsa045400.72446352
103Type I diabetes mellitus_Homo sapiens_hsa049400.71785018
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71666908
105Graft-versus-host disease_Homo sapiens_hsa053320.71443951
106Viral myocarditis_Homo sapiens_hsa054160.70218280
107Influenza A_Homo sapiens_hsa051640.69685614
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68405540
109Pancreatic cancer_Homo sapiens_hsa052120.68099172
110Prolactin signaling pathway_Homo sapiens_hsa049170.67956559
111Ras signaling pathway_Homo sapiens_hsa040140.67700698
112Melanogenesis_Homo sapiens_hsa049160.67281623
113Collecting duct acid secretion_Homo sapiens_hsa049660.67132429
114Endocytosis_Homo sapiens_hsa041440.66123713
115T cell receptor signaling pathway_Homo sapiens_hsa046600.66123545
116Insulin resistance_Homo sapiens_hsa049310.66070492
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66003100
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65978671
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.65923843
120Pancreatic secretion_Homo sapiens_hsa049720.65502202
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63817138
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63365059
123Autoimmune thyroid disease_Homo sapiens_hsa053200.63255280
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.63029356
125Endometrial cancer_Homo sapiens_hsa052130.60991912
126HIF-1 signaling pathway_Homo sapiens_hsa040660.59927382
127Hematopoietic cell lineage_Homo sapiens_hsa046400.58899541
128Complement and coagulation cascades_Homo sapiens_hsa046100.58664978

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