MEF2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.38637092
2presynaptic membrane assembly (GO:0097105)6.88960385
3sarcoplasmic reticulum calcium ion transport (GO:0070296)6.49962202
4glutamate secretion (GO:0014047)6.46572061
5vocalization behavior (GO:0071625)6.25400223
6presynaptic membrane organization (GO:0097090)6.14977127
7synaptic vesicle exocytosis (GO:0016079)6.11573758
8neurotransmitter-gated ion channel clustering (GO:0072578)6.05767357
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.05252731
10postsynaptic membrane organization (GO:0001941)5.89189591
11protein localization to synapse (GO:0035418)5.84414631
12* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.83737275
13neuron cell-cell adhesion (GO:0007158)5.83658358
14muscle filament sliding (GO:0030049)5.82488991
15actin-myosin filament sliding (GO:0033275)5.82488991
16regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58948740
17regulation of synaptic vesicle exocytosis (GO:2000300)5.57505189
18regulation of skeletal muscle contraction (GO:0014819)5.37250557
19* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.34628837
20* regulation of glutamate receptor signaling pathway (GO:1900449)5.18088617
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.13036782
22skeletal muscle contraction (GO:0003009)5.05146338
23positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.03014906
24neuronal action potential propagation (GO:0019227)4.98187176
25locomotory exploration behavior (GO:0035641)4.95169128
26synaptic vesicle maturation (GO:0016188)4.89202862
27positive regulation of synapse maturation (GO:0090129)4.88070060
28regulation of synaptic vesicle transport (GO:1902803)4.85586324
29cerebellar granule cell differentiation (GO:0021707)4.76185793
30actin-mediated cell contraction (GO:0070252)4.65797994
31regulation of relaxation of muscle (GO:1901077)4.65656367
32negative regulation of synaptic transmission, GABAergic (GO:0032229)4.63268210
33positive regulation of neurotransmitter secretion (GO:0001956)4.53815724
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.49925081
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.46999827
36gamma-aminobutyric acid signaling pathway (GO:0007214)4.43016563
37regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.41396832
38neuron-neuron synaptic transmission (GO:0007270)4.39402663
39striated muscle contraction (GO:0006941)4.35849412
40ionotropic glutamate receptor signaling pathway (GO:0035235)4.35027001
41neurotransmitter secretion (GO:0007269)4.28664368
42synaptic transmission, glutamatergic (GO:0035249)4.27997680
43response to histamine (GO:0034776)4.27746432
44glutamate receptor signaling pathway (GO:0007215)4.22373974
45positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.20167458
46long-term synaptic potentiation (GO:0060291)4.17438678
47positive regulation of membrane potential (GO:0045838)4.14593248
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14393381
49regulation of synapse maturation (GO:0090128)4.08488924
50* myofibril assembly (GO:0030239)4.03543997
51regulation of calcium ion transmembrane transport (GO:1903169)4.03091119
52regulation of calcium ion transmembrane transporter activity (GO:1901019)4.03091119
53* regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01879155
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.98745932
55mechanosensory behavior (GO:0007638)3.97596939
56exploration behavior (GO:0035640)3.96319557
57positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.89949046
58* regulation of postsynaptic membrane potential (GO:0060078)3.87914111
59sodium ion export (GO:0071436)3.87287556
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82022291
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81112474
62cardiac muscle contraction (GO:0060048)3.80719927
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80339358
64regulation of actin filament-based movement (GO:1903115)3.79406615
65cellular potassium ion homeostasis (GO:0030007)3.78688648
66positive regulation of neurotransmitter transport (GO:0051590)3.76003862
67negative regulation of dendrite morphogenesis (GO:0050774)3.75830695
68response to inactivity (GO:0014854)3.71640599
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.65986979
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63431593
71* regulation of neurotransmitter secretion (GO:0046928)3.63431577
72regulation of membrane repolarization (GO:0060306)3.59627780
73auditory behavior (GO:0031223)3.59366896
74regulation of neuronal synaptic plasticity (GO:0048168)3.57671305
75nerve growth factor signaling pathway (GO:0038180)3.57638485
76response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.57576994
77actin filament-based movement (GO:0030048)3.56398379
78regulation of synapse structural plasticity (GO:0051823)3.56222272
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.55996492
80membrane assembly (GO:0071709)3.53354533
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.52024092
82* regulation of synaptic plasticity (GO:0048167)3.51446773
83regulation of dendritic spine morphogenesis (GO:0061001)3.49904999
84startle response (GO:0001964)3.49146995
85skeletal muscle fiber development (GO:0048741)3.47823319
86gamma-aminobutyric acid transport (GO:0015812)3.47687507
87negative regulation of dendrite development (GO:2000171)3.47226429
88* regulation of synaptic transmission, glutamatergic (GO:0051966)3.47153594
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44582861
90positive regulation of potassium ion transmembrane transport (GO:1901381)3.40168425
91regulation of voltage-gated calcium channel activity (GO:1901385)3.37539569
92muscle cell cellular homeostasis (GO:0046716)3.37084792
93positive regulation of synapse assembly (GO:0051965)3.36327461
94neuron recognition (GO:0008038)3.34736008
95long-term memory (GO:0007616)3.34384654
96myotube cell development (GO:0014904)3.28917670
97regulation of striated muscle contraction (GO:0006942)3.28493573
98synaptic vesicle endocytosis (GO:0048488)3.28089158
99positive regulation of synaptic transmission (GO:0050806)3.27153626
100regulation of cardiac muscle cell contraction (GO:0086004)3.26813282
101* cardiac myofibril assembly (GO:0055003)3.26809222
102regulation of cell communication by electrical coupling (GO:0010649)3.24564375
103neurotransmitter transport (GO:0006836)3.21651502
104behavioral response to cocaine (GO:0048148)3.18661250
105activation of protein kinase A activity (GO:0034199)3.18135579
106negative regulation of potassium ion transmembrane transport (GO:1901380)3.17766465
107plasma membrane repair (GO:0001778)3.17393093
108cerebellar Purkinje cell differentiation (GO:0021702)3.17242604
109* membrane depolarization (GO:0051899)3.16807558
110potassium ion import (GO:0010107)3.15787627
111positive regulation of dendritic spine morphogenesis (GO:0061003)3.13626019
112central nervous system projection neuron axonogenesis (GO:0021952)3.13415580
113* regulation of neurotransmitter transport (GO:0051588)3.13351830
114positive regulation of cation channel activity (GO:2001259)3.13169942
115vesicle docking involved in exocytosis (GO:0006904)3.12968343
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.12442692
117sarcomere organization (GO:0045214)3.12171749
118layer formation in cerebral cortex (GO:0021819)3.10283940
119neuromuscular synaptic transmission (GO:0007274)3.09824623
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09570946
121negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.09333713
122negative regulation of calcium ion transmembrane transport (GO:1903170)3.09333713
123vesicle docking (GO:0048278)3.09286538
124detection of calcium ion (GO:0005513)3.09091132
125regulation of potassium ion transmembrane transporter activity (GO:1901016)3.08822393
126transferrin transport (GO:0033572)3.02838080
127positive regulation of potassium ion transport (GO:0043268)3.02623443
128cell communication by electrical coupling (GO:0010644)3.01856596
129learning (GO:0007612)3.01837318
130positive regulation of dendritic spine development (GO:0060999)3.01741752
131synapse assembly (GO:0007416)3.01684511
132proline transport (GO:0015824)3.01305350
133synaptic transmission (GO:0007268)3.00752607
134axonal fasciculation (GO:0007413)2.99924614
135regulation of vesicle fusion (GO:0031338)2.99335159
136regulation of neurotransmitter levels (GO:0001505)2.98721942
137cell communication involved in cardiac conduction (GO:0086065)2.98252687
138response to auditory stimulus (GO:0010996)2.98087097
139positive regulation of myotube differentiation (GO:0010831)2.96537615
140* regulation of dendritic spine development (GO:0060998)2.95595582
141response to muscle activity (GO:0014850)2.93740230
142* regulation of synaptic transmission (GO:0050804)2.92733543
143regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92160497
144regulation of respiratory system process (GO:0044065)2.91366503
145regulation of cation channel activity (GO:2001257)2.90958090
146relaxation of cardiac muscle (GO:0055119)2.90346905
147fear response (GO:0042596)2.89211730
148cochlea development (GO:0090102)2.89137023
149membrane depolarization during action potential (GO:0086010)2.88648168
150inositol phosphate catabolic process (GO:0071545)2.87312667
151long term synaptic depression (GO:0060292)2.87073170
152serotonin metabolic process (GO:0042428)2.85958626
153membrane hyperpolarization (GO:0060081)2.85723537
154establishment of synaptic vesicle localization (GO:0097480)2.85314655
155synaptic vesicle transport (GO:0048489)2.85314655
156ATP hydrolysis coupled proton transport (GO:0015991)2.85045593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75009821
2GBX2_23144817_ChIP-Seq_PC3_Human5.02657611
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07098580
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87698043
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85613276
6* TAF15_26573619_Chip-Seq_HEK293_Human2.74946793
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.57202404
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50981033
9REST_21632747_ChIP-Seq_MESCs_Mouse2.47609926
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34269012
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34113676
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.33862686
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31163295
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.30741912
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30045328
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30045328
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25027091
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22034715
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19605286
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18876986
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18600429
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15014097
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13340617
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12487153
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08199390
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08109374
27DROSHA_22980978_ChIP-Seq_HELA_Human2.06252642
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.05870929
29GATA1_22025678_ChIP-Seq_K562_Human2.04295030
30AR_21572438_ChIP-Seq_LNCaP_Human2.00961777
31CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00738265
32P300_19829295_ChIP-Seq_ESCs_Human1.99846916
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.99782721
34SMAD4_21799915_ChIP-Seq_A2780_Human1.98101155
35* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92123660
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.87438060
37* FUS_26573619_Chip-Seq_HEK293_Human1.85177869
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85003715
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84785554
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75417609
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.72781359
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67232399
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60995198
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58599956
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58584274
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57881125
47AR_25329375_ChIP-Seq_VCAP_Human1.55374149
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.53965834
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52462690
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50528486
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.49235186
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.48150277
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37305341
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36791037
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36561077
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36346549
57STAT3_23295773_ChIP-Seq_U87_Human1.35004806
58TCF4_23295773_ChIP-Seq_U87_Human1.34572048
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.33358261
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33009803
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32631342
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31869467
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31762227
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.30048372
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.29791755
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.28726805
67ER_23166858_ChIP-Seq_MCF-7_Human1.28163439
68VDR_22108803_ChIP-Seq_LS180_Human1.26718146
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25709572
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25514611
71RNF2_27304074_Chip-Seq_NSC_Mouse1.24800723
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24793254
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.24183764
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23646360
75* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22827014
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22819143
77TP53_16413492_ChIP-PET_HCT116_Human1.22386818
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21254435
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21138883
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18669393
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18345487
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17883817
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.15128096
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14736992
85AHR_22903824_ChIP-Seq_MCF-7_Human1.14393318
86TP53_18474530_ChIP-ChIP_U2OS_Human1.14322203
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12400692
88* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12287163
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11493890
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10606980
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10606980
92JUN_21703547_ChIP-Seq_K562_Human1.10475633
93* SOX9_26525672_Chip-Seq_HEART_Mouse1.10456875
94ZNF274_21170338_ChIP-Seq_K562_Hela1.10360228
95P53_22387025_ChIP-Seq_ESCs_Mouse1.09569940
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.09518274
97* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08981913
98* AR_19668381_ChIP-Seq_PC3_Human1.07884839
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07470728
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07183826
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07177774
102EWS_26573619_Chip-Seq_HEK293_Human1.06712849
103RUNX2_22187159_ChIP-Seq_PCA_Human1.05489850
104* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05357236
105* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04589286
106* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04589286
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04470056
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04202617
109CBP_20019798_ChIP-Seq_JUKART_Human1.04181488
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04181488
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02398189
112IGF1R_20145208_ChIP-Seq_DFB_Human1.02017974
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01938015
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01868430
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01607654
116KDM2B_26808549_Chip-Seq_REH_Human1.01107506
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.00530179
118RXR_22108803_ChIP-Seq_LS180_Human0.98495842
119* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97800877
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96013845
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95594891
122VDR_24787735_ChIP-Seq_THP-1_Human0.95369635
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94791088
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91893861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90533346
2MP0003880_abnormal_central_pattern5.58050281
3MP0003635_abnormal_synaptic_transmissio4.10247726
4MP0004270_analgesia3.86399449
5MP0001968_abnormal_touch/_nociception3.60747117
6MP0009745_abnormal_behavioral_response3.59679103
7MP0002063_abnormal_learning/memory/cond3.36792736
8MP0009046_muscle_twitch3.29669055
9MP0002064_seizures3.25786505
10MP0002572_abnormal_emotion/affect_behav2.91917798
11MP0002736_abnormal_nociception_after2.87050292
12MP0009780_abnormal_chondrocyte_physiolo2.80253933
13MP0002734_abnormal_mechanical_nocicepti2.57075261
14MP0003879_abnormal_hair_cell2.44176893
15MP0002272_abnormal_nervous_system2.37411166
16MP0001486_abnormal_startle_reflex2.36846287
17MP0005423_abnormal_somatic_nervous2.27836077
18MP0002067_abnormal_sensory_capabilities2.21010684
19MP0002735_abnormal_chemical_nociception2.20521789
20MP0003787_abnormal_imprinting2.14487031
21MP0001501_abnormal_sleep_pattern2.08440290
22MP0005646_abnormal_pituitary_gland2.02212296
23MP0004087_abnormal_muscle_fiber2.01408194
24* MP0000759_abnormal_skeletal_muscle2.00795804
25MP0001440_abnormal_grooming_behavior1.97893365
26MP0000751_myopathy1.83077139
27MP0001188_hyperpigmentation1.78787185
28MP0004145_abnormal_muscle_electrophysio1.77692687
29MP0005386_behavior/neurological_phenoty1.76341150
30MP0004924_abnormal_behavior1.76341150
31MP0008569_lethality_at_weaning1.74764401
32MP0002332_abnormal_exercise_endurance1.70250237
33MP0002733_abnormal_thermal_nociception1.66808727
34MP0002269_muscular_atrophy1.65932365
35MP0001970_abnormal_pain_threshold1.65237062
36MP0002557_abnormal_social/conspecific_i1.63990202
37MP0002837_dystrophic_cardiac_calcinosis1.62367953
38MP0004811_abnormal_neuron_physiology1.54539341
39MP0000778_abnormal_nervous_system1.53514061
40MP0002876_abnormal_thyroid_physiology1.44052851
41MP0001984_abnormal_olfaction1.41760540
42MP0002184_abnormal_innervation1.38746366
43MP0003633_abnormal_nervous_system1.38713561
44MP0000750_abnormal_muscle_regeneration1.35166668
45MP0004484_altered_response_of1.35114816
46MP0003045_fibrosis1.26452483
47* MP0002066_abnormal_motor_capabilities/c1.26006421
48MP0003950_abnormal_plasma_membrane1.24506064
49MP0004215_abnormal_myocardial_fiber1.23311167
50MP0002822_catalepsy1.21466499
51MP0003646_muscle_fatigue1.20563862
52MP0005330_cardiomyopathy1.18980626
53MP0000749_muscle_degeneration1.16661843
54MP0004036_abnormal_muscle_relaxation1.14516602
55MP0000733_abnormal_muscle_development1.13540402
56MP0002909_abnormal_adrenal_gland1.12983891
57MP0001905_abnormal_dopamine_level1.11113304
58MP0003183_abnormal_peptide_metabolism1.10121328
59MP0003631_nervous_system_phenotype1.08367323
60MP0002882_abnormal_neuron_morphology1.08021257
61MP0001502_abnormal_circadian_rhythm1.07722553
62MP0003828_pulmonary_edema1.07498037
63MP0004510_myositis1.06605358
64MP0000955_abnormal_spinal_cord1.06573081
65MP0004085_abnormal_heartbeat1.04990146
66MP0008874_decreased_physiological_sensi1.04105986
67MP0003137_abnormal_impulse_conducting1.02168758
68MP0000569_abnormal_digit_pigmentation1.01857946
69MP0005171_absent_coat_pigmentation1.00534188
70MP0003329_amyloid_beta_deposits0.99217751
71MP0006276_abnormal_autonomic_nervous0.98843808
72MP0003122_maternal_imprinting0.98297223
73MP0003303_peritoneal_inflammation0.96852127
74MP0004130_abnormal_muscle_cell0.95694668
75MP0008877_abnormal_DNA_methylation0.90742087
76MP0004142_abnormal_muscle_tone0.90324542
77MP0000013_abnormal_adipose_tissue0.89824269
78MP0001963_abnormal_hearing_physiology0.87589097
79MP0008004_abnormal_stomach_pH0.87336966
80MP0008872_abnormal_physiological_respon0.86846122
81MP0002152_abnormal_brain_morphology0.85838669
82MP0005167_abnormal_blood-brain_barrier0.84923606
83MP0001529_abnormal_vocalization0.84052718
84MP0005385_cardiovascular_system_phenoty0.83702190
85MP0001544_abnormal_cardiovascular_syste0.83702190
86MP0003690_abnormal_glial_cell0.80995985
87MP0001986_abnormal_taste_sensitivity0.80952826
88* MP0005620_abnormal_muscle_contractility0.80171611
89MP0004233_abnormal_muscle_weight0.79561434
90MP0000920_abnormal_myelination0.79183383
91MP0000015_abnormal_ear_pigmentation0.77066825
92MP0005084_abnormal_gallbladder_morpholo0.76736138
93MP0002108_abnormal_muscle_morphology0.76327350
94MP0001664_abnormal_digestion0.75621974
95* MP0010630_abnormal_cardiac_muscle0.75610866
96MP0005551_abnormal_eye_electrophysiolog0.74649377
97MP0010386_abnormal_urinary_bladder0.73393893
98MP0002069_abnormal_eating/drinking_beha0.72869413
99MP0000631_abnormal_neuroendocrine_gland0.67790099
100MP0006036_abnormal_mitochondrial_physio0.66296178
101MP0004084_abnormal_cardiac_muscle0.66006787
102MP0008775_abnormal_heart_ventricle0.65136634
103MP0004742_abnormal_vestibular_system0.64375972
104MP0005535_abnormal_body_temperature0.64367467
105MP0005451_abnormal_body_composition0.64011376
106MP0005409_darkened_coat_color0.63498954
107MP0002229_neurodegeneration0.63402502
108MP0002106_abnormal_muscle_physiology0.63135522
109MP0006138_congestive_heart_failure0.62673853
110MP0005645_abnormal_hypothalamus_physiol0.62646374
111MP0000465_gastrointestinal_hemorrhage0.62271571
112MP0004134_abnormal_chest_morphology0.62206130
113MP0003075_altered_response_to0.61991889
114MP0003221_abnormal_cardiomyocyte_apopto0.61465322
115MP0005166_decreased_susceptibility_to0.59131088
116MP0004858_abnormal_nervous_system0.58681662
117MP0000747_muscle_weakness0.58432272
118MP0004147_increased_porphyrin_level0.58092897
119MP0004043_abnormal_pH_regulation0.57557842
120MP0005187_abnormal_penis_morphology0.56533796
121MP0000681_abnormal_thyroid_gland0.55975013
122MP0005369_muscle_phenotype0.55943966
123* MP0002972_abnormal_cardiac_muscle0.55269613
124MP0001177_atelectasis0.53367108
125* MP0001943_abnormal_respiration0.52097972
126* MP0010770_preweaning_lethality0.49604441
127* MP0002082_postnatal_lethality0.49604441
128MP0003956_abnormal_body_size0.49544351
129* MP0010769_abnormal_survival0.48434482

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.43306330
2Hyperventilation (HP:0002883)7.04654354
3Atonic seizures (HP:0010819)6.36516125
4* Epileptic encephalopathy (HP:0200134)6.23694078
5Distal arthrogryposis (HP:0005684)5.78136173
6Febrile seizures (HP:0002373)5.74478911
7Focal seizures (HP:0007359)5.73929674
8Broad-based gait (HP:0002136)5.34447837
9Exercise-induced muscle cramps (HP:0003710)5.34182446
10Type 1 muscle fiber predominance (HP:0003803)5.06462175
11Absence seizures (HP:0002121)4.80187060
12Dialeptic seizures (HP:0011146)4.45450240
13Visual hallucinations (HP:0002367)4.34508107
14Protruding tongue (HP:0010808)4.29958902
15Round ear (HP:0100830)4.29756303
16Sudden death (HP:0001699)4.24340344
17Hyporeflexia of lower limbs (HP:0002600)4.09846731
18Myokymia (HP:0002411)4.03238124
19Subaortic stenosis (HP:0001682)3.86569387
20Abnormality of the left ventricular outflow tract (HP:0011103)3.86569387
21Generalized tonic-clonic seizures (HP:0002069)3.84015814
22Gaze-evoked nystagmus (HP:0000640)3.75829212
23EMG: myopathic abnormalities (HP:0003458)3.66337048
24Ulnar deviation of the wrist (HP:0003049)3.56909456
25Muscle fiber splitting (HP:0003555)3.45496891
26Neck muscle weakness (HP:0000467)3.43441330
27Amblyopia (HP:0000646)3.38790320
28Difficulty running (HP:0009046)3.33441193
29Excessive salivation (HP:0003781)3.30284896
30Drooling (HP:0002307)3.30284896
31Myopathic facies (HP:0002058)3.29003815
32Progressive cerebellar ataxia (HP:0002073)3.24426615
33Fetal akinesia sequence (HP:0001989)3.18328525
34Malignant hyperthermia (HP:0002047)3.15265426
35Centrally nucleated skeletal muscle fibers (HP:0003687)3.08209242
36Dysmetric saccades (HP:0000641)3.05877225
37Absent phalangeal crease (HP:0006109)3.04465902
38Impaired vibration sensation in the lower limbs (HP:0002166)2.94290957
39Absent speech (HP:0001344)2.91920558
40Rimmed vacuoles (HP:0003805)2.85178954
41Epileptiform EEG discharges (HP:0011182)2.85067232
42Urinary bladder sphincter dysfunction (HP:0002839)2.83985663
43Calcaneovalgus deformity (HP:0001848)2.83708965
44* Poor eye contact (HP:0000817)2.81453991
45Bundle branch block (HP:0011710)2.76423904
46Papilledema (HP:0001085)2.74079315
47EMG: neuropathic changes (HP:0003445)2.71442283
48Generalized hypopigmentation of hair (HP:0011358)2.69887594
49Muscle stiffness (HP:0003552)2.69544231
50Frequent falls (HP:0002359)2.68997974
51Impaired smooth pursuit (HP:0007772)2.68943602
52Asymmetric septal hypertrophy (HP:0001670)2.68515560
53Rhabdomyolysis (HP:0003201)2.67535128
54Truncal ataxia (HP:0002078)2.66079686
55Fair hair (HP:0002286)2.65775302
56Gowers sign (HP:0003391)2.65009997
57Abnormal eating behavior (HP:0100738)2.64239037
58Inappropriate behavior (HP:0000719)2.62029137
59Abnormality of skeletal muscle fiber size (HP:0012084)2.61774308
60Abnormal finger flexion creases (HP:0006143)2.61358190
61Type 2 muscle fiber atrophy (HP:0003554)2.60408634
62Myoglobinuria (HP:0002913)2.60258750
63Abnormal hair whorl (HP:0010721)2.59679937
64Exercise-induced myalgia (HP:0003738)2.58628448
65Action tremor (HP:0002345)2.56948405
66Areflexia of lower limbs (HP:0002522)2.56282411
67Weak cry (HP:0001612)2.55761728
68Progressive inability to walk (HP:0002505)2.55187571
69Popliteal pterygium (HP:0009756)2.51260320
70Blue irides (HP:0000635)2.49214636
71Dysdiadochokinesis (HP:0002075)2.49057022
72Fatigable weakness (HP:0003473)2.48998468
73Abnormality of the neuromuscular junction (HP:0003398)2.48998468
74Prolonged QT interval (HP:0001657)2.48961783
75Distal lower limb muscle weakness (HP:0009053)2.46302994
76Muscle hypertrophy of the lower extremities (HP:0008968)2.44234035
77Deformed tarsal bones (HP:0008119)2.43828765
78EEG with generalized epileptiform discharges (HP:0011198)2.42618700
79Polyphagia (HP:0002591)2.41603964
80Hyperthyroidism (HP:0000836)2.38814231
81* Inability to walk (HP:0002540)2.35724905
82Depression (HP:0000716)2.34279252
83Insidious onset (HP:0003587)2.29599492
84Termporal pattern (HP:0011008)2.29599492
85Gait imbalance (HP:0002141)2.28428743
86Impaired vibratory sensation (HP:0002495)2.27748871
87Diplopia (HP:0000651)2.27148875
88Abnormality of binocular vision (HP:0011514)2.27148875
89Mutism (HP:0002300)2.27132750
90Increased variability in muscle fiber diameter (HP:0003557)2.26518750
91* Impaired social interactions (HP:0000735)2.26099169
92* Abnormal social behavior (HP:0012433)2.26099169
93Genetic anticipation (HP:0003743)2.25763958
94Abnormality of salivation (HP:0100755)2.23919981
95Lower limb amyotrophy (HP:0007210)2.23099681
96Status epilepticus (HP:0002133)2.21517726
97* Stereotypic behavior (HP:0000733)2.21043360
98Akinesia (HP:0002304)2.20699836
99Calf muscle hypertrophy (HP:0008981)2.20677343
100Muscle fiber atrophy (HP:0100295)2.18978870
101Scanning speech (HP:0002168)2.18834326
102Lower limb muscle weakness (HP:0007340)2.18786445
103Hypsarrhythmia (HP:0002521)2.17239058
104Abnormality of ocular smooth pursuit (HP:0000617)2.15802723
105Nonprogressive disorder (HP:0003680)2.12320274
106Syncope (HP:0001279)2.12176379
107Thyroid-stimulating hormone excess (HP:0002925)2.11024369
108Myotonia (HP:0002486)2.10901826
109Urinary urgency (HP:0000012)2.10740199
110Abnormal EKG (HP:0003115)2.07718006
111Ankle clonus (HP:0011448)2.06384846
112Hemiplegia (HP:0002301)2.05712246
113Generalized myoclonic seizures (HP:0002123)2.04710856
114Anxiety (HP:0000739)2.04626314
115Bradykinesia (HP:0002067)2.01161161
116Bulbar palsy (HP:0001283)2.00829959
117Exotropia (HP:0000577)1.99598756
118Long clavicles (HP:0000890)1.98605786
119Dysmetria (HP:0001310)1.98022022
120Postural instability (HP:0002172)1.96680619
121Obstructive sleep apnea (HP:0002870)1.96435721
122Generalized muscle weakness (HP:0003324)1.95829341
123Abnormality of the calf musculature (HP:0001430)1.94576270
124Widely spaced teeth (HP:0000687)1.94481971
125Increased connective tissue (HP:0009025)1.93944352
126Shoulder girdle muscle weakness (HP:0003547)1.93068330
127Amniotic constriction ring (HP:0009775)1.92222347
128Abnormality of placental membranes (HP:0011409)1.92222347
129Incomplete penetrance (HP:0003829)1.90204752
130Gastroesophageal reflux (HP:0002020)1.89924209
131Hip contracture (HP:0003273)1.88195147
132Muscle fiber inclusion bodies (HP:0100299)1.87420865
133Abnormality of the lower motor neuron (HP:0002366)1.87297024
134Heart block (HP:0012722)1.86746874
135Spastic gait (HP:0002064)1.85070101
136Medial flaring of the eyebrow (HP:0010747)1.83644699
137Progressive microcephaly (HP:0000253)1.81701096
138Steppage gait (HP:0003376)1.81699111
139Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81281110
140Hypoplasia of the brainstem (HP:0002365)1.81281110
141Pheochromocytoma (HP:0002666)1.79022592
142Sleep apnea (HP:0010535)1.78767167
143Resting tremor (HP:0002322)1.78679877
144Congenital primary aphakia (HP:0007707)1.78337984
145Facial diplegia (HP:0001349)1.78139915
146Hemiparesis (HP:0001269)1.77920345
147Atrial fibrillation (HP:0005110)1.77413132
148Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77313354
149Primary atrial arrhythmia (HP:0001692)1.77165653
150Nemaline bodies (HP:0003798)1.77117040
151Distal lower limb amyotrophy (HP:0008944)1.76322455
152Abnormality of alanine metabolism (HP:0010916)1.76274955
153Hyperalaninemia (HP:0003348)1.76274955
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76274955
155* Intellectual disability, severe (HP:0010864)1.75443953
156Nephrogenic diabetes insipidus (HP:0009806)1.75356995
157Abnormality of the corticospinal tract (HP:0002492)1.75104650
158Gait ataxia (HP:0002066)1.74135044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.91430315
2EPHA43.83322599
3DAPK23.74466436
4CDK193.46863029
5MAP2K73.29129662
6NTRK33.10887342
7MAP3K42.94966494
8MAP3K122.86203763
9MARK12.79762619
10DAPK12.77248987
11PLK22.51631388
12MAP3K92.42708223
13RIPK42.11191726
14PIK3CG2.03888384
15PINK11.98424260
16MAP2K41.96980755
17CAMKK21.75259973
18MINK11.75150453
19PRPF4B1.74080723
20AKT31.64965483
21CAMKK11.45540012
22MAPK131.43247460
23OXSR11.42733913
24TNIK1.38876740
25TTN1.35072577
26PAK61.32569850
27KSR11.22035743
28FRK1.21116126
29SIK21.20910422
30SGK21.19899555
31CDK51.19056140
32SIK31.16405606
33PKN11.16089407
34NTRK21.13951187
35TSSK61.07339983
36GRK51.02683513
37EPHA31.00792409
38PRKCG0.98282261
39FES0.96551807
40DMPK0.95143694
41TIE10.94319980
42OBSCN0.94029535
43PDK30.90865846
44PDK40.90865846
45PTK2B0.90519460
46BMPR20.86123467
47PHKG20.85578810
48PHKG10.85578810
49PIK3CA0.84559173
50SGK4940.83559422
51SGK2230.83559422
52CAMK2A0.83237610
53CAMK10.83184774
54KSR20.80413501
55DAPK30.78816461
56CDK180.78355654
57SGK30.76254432
58PRKD30.75908254
59MUSK0.73830944
60MAP3K60.73400230
61CDK150.71195695
62SGK10.69852250
63RAF10.68852919
64STK110.66528543
65CAMK2G0.65452778
66PDK10.65046781
67CDK30.62523224
68CDK140.62363178
69CDK11A0.61782282
70LATS20.60809009
71SYK0.59105187
72MAPKAPK50.58109413
73MAP3K130.55669781
74PRKCE0.55168495
75PDK20.54578415
76CAMK2B0.53940396
77ARAF0.53697829
78MAPK100.52652502
79MYLK0.52390787
80NME10.52102692
81* MAPK40.51286414
82PNCK0.50295711
83MAP3K100.49848634
84DYRK1A0.48643409
85PDPK10.48591878
86CAMK40.48348428
87CDK80.47139576
88BLK0.46546281
89TAOK10.45722910
90PAK30.45639966
91ADRBK20.45178378
92MAP2K60.44463585
93BRAF0.44309613
94ROCK10.43392024
95TEC0.41411594
96WNK30.41337683
97PRKCQ0.41064064
98UHMK10.40947402
99NTRK10.40893653
100PRKACB0.40069991
101CSNK1G20.39609255
102MOS0.38766591
103RET0.36997478
104PRKCZ0.36336865
105TAOK20.35756234
106PRKCH0.35412655
107* PRKACA0.34722465
108TNK20.34479708
109CAMK2D0.34470291
110JAK20.33751379
111CSF1R0.33647855
112ADRBK10.33493907
113MAP3K70.33041167
114MAPKAPK30.32363650
115CSNK1D0.32354053
116NEK10.31676232
117KIT0.31448491
118JAK10.30862842
119TRPM70.30303306
120PRKG10.29581100
121PRKCB0.29399916
122ERBB30.27159320
123ROCK20.26887813
124MAP2K10.26868521
125FYN0.26158339
126MAP3K20.25904425
127* RPS6KA30.25301393
128MARK20.25294682
129FGR0.24715065
130* MAPK120.24325282
131GRK60.24206500
132MAP3K50.22913535
133GRK70.20401088

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87760555
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69019370
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87924411
4Circadian entrainment_Homo sapiens_hsa047132.80882960
5Long-term potentiation_Homo sapiens_hsa047202.78659546
6Olfactory transduction_Homo sapiens_hsa047402.66841346
7Morphine addiction_Homo sapiens_hsa050322.60816204
8Amphetamine addiction_Homo sapiens_hsa050312.46103449
9Collecting duct acid secretion_Homo sapiens_hsa049662.37591175
10Glutamatergic synapse_Homo sapiens_hsa047242.36917196
11GABAergic synapse_Homo sapiens_hsa047272.35690681
12Salivary secretion_Homo sapiens_hsa049702.14923659
13Renin secretion_Homo sapiens_hsa049242.06185785
14Dopaminergic synapse_Homo sapiens_hsa047282.04528938
15* Oxytocin signaling pathway_Homo sapiens_hsa049211.87726936
16Insulin secretion_Homo sapiens_hsa049111.84095889
17Long-term depression_Homo sapiens_hsa047301.77736335
18Calcium signaling pathway_Homo sapiens_hsa040201.74288590
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72690754
20Taste transduction_Homo sapiens_hsa047421.72278264
21Cholinergic synapse_Homo sapiens_hsa047251.69518922
22Gastric acid secretion_Homo sapiens_hsa049711.69146052
23Serotonergic synapse_Homo sapiens_hsa047261.65179362
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61091701
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46025933
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45248376
27Vibrio cholerae infection_Homo sapiens_hsa051101.34443629
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33480734
29GnRH signaling pathway_Homo sapiens_hsa049121.27284928
30Gap junction_Homo sapiens_hsa045401.24830884
31cAMP signaling pathway_Homo sapiens_hsa040241.22323523
32Asthma_Homo sapiens_hsa053101.17706779
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16475943
34* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14612900
35Cocaine addiction_Homo sapiens_hsa050301.14452163
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12331162
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09426430
38Glioma_Homo sapiens_hsa052141.09153464
39ErbB signaling pathway_Homo sapiens_hsa040121.08563787
40Phototransduction_Homo sapiens_hsa047441.07932565
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07792233
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.07659561
43Axon guidance_Homo sapiens_hsa043601.05885335
44Dilated cardiomyopathy_Homo sapiens_hsa054141.03068439
45Viral myocarditis_Homo sapiens_hsa054161.00986576
46Cardiac muscle contraction_Homo sapiens_hsa042600.99208218
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.98702240
48Estrogen signaling pathway_Homo sapiens_hsa049150.98171423
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92473742
50Circadian rhythm_Homo sapiens_hsa047100.91717478
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91619556
52Type II diabetes mellitus_Homo sapiens_hsa049300.91009682
53* MAPK signaling pathway_Homo sapiens_hsa040100.85360609
54Allograft rejection_Homo sapiens_hsa053300.84050505
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83656850
56Melanogenesis_Homo sapiens_hsa049160.82836863
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80427069
58Oocyte meiosis_Homo sapiens_hsa041140.74962315
59Autoimmune thyroid disease_Homo sapiens_hsa053200.73345779
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72674333
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71073389
62Rheumatoid arthritis_Homo sapiens_hsa053230.70700568
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70442936
64Graft-versus-host disease_Homo sapiens_hsa053320.70376829
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69523574
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69198466
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.68264529
68Glucagon signaling pathway_Homo sapiens_hsa049220.68010098
69B cell receptor signaling pathway_Homo sapiens_hsa046620.66775134
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66015370
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65965886
72Ras signaling pathway_Homo sapiens_hsa040140.65356605
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64180358
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63277916
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63238925
76African trypanosomiasis_Homo sapiens_hsa051430.62188108
77Alzheimers disease_Homo sapiens_hsa050100.61238604
78Platelet activation_Homo sapiens_hsa046110.59635452
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59314729
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57087821
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56628379
82Oxidative phosphorylation_Homo sapiens_hsa001900.53850846
83VEGF signaling pathway_Homo sapiens_hsa043700.53600517
84Inositol phosphate metabolism_Homo sapiens_hsa005620.52655219
85Thyroid hormone synthesis_Homo sapiens_hsa049180.52267704
86Leishmaniasis_Homo sapiens_hsa051400.51025688
87Pancreatic secretion_Homo sapiens_hsa049720.50826108
88Phagosome_Homo sapiens_hsa041450.50203479
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47664973
90Rap1 signaling pathway_Homo sapiens_hsa040150.47218910
91Colorectal cancer_Homo sapiens_hsa052100.46789523
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46708433
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46431456
94Chemokine signaling pathway_Homo sapiens_hsa040620.44574671
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.44495202
96Insulin signaling pathway_Homo sapiens_hsa049100.44459131
97Focal adhesion_Homo sapiens_hsa045100.44062329
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42544739
99Choline metabolism in cancer_Homo sapiens_hsa052310.42018682
100AMPK signaling pathway_Homo sapiens_hsa041520.41550014
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.40943266
102Alcoholism_Homo sapiens_hsa050340.40912694
103Wnt signaling pathway_Homo sapiens_hsa043100.40027726
104Renal cell carcinoma_Homo sapiens_hsa052110.39791326
105Insulin resistance_Homo sapiens_hsa049310.39592641
106Osteoclast differentiation_Homo sapiens_hsa043800.39272401
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39206896
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39047122
109Non-small cell lung cancer_Homo sapiens_hsa052230.38951466
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38353916
111Endometrial cancer_Homo sapiens_hsa052130.38155932
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37607488
113Tuberculosis_Homo sapiens_hsa051520.37182219
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36450497
115Type I diabetes mellitus_Homo sapiens_hsa049400.35237735
116FoxO signaling pathway_Homo sapiens_hsa040680.35163536
117mTOR signaling pathway_Homo sapiens_hsa041500.34439954
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.34327623
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33990997
120Toxoplasmosis_Homo sapiens_hsa051450.33789893
121Dorso-ventral axis formation_Homo sapiens_hsa043200.33523175
122Prolactin signaling pathway_Homo sapiens_hsa049170.32465996

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