MEF2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.95088572
2negative regulation of erythrocyte differentiation (GO:0045647)4.94125740
3sodium ion export (GO:0071436)4.40752146
4locomotory exploration behavior (GO:0035641)4.39749313
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.33170195
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13137644
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01497333
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.95117779
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94861328
10response to muramyl dipeptide (GO:0032495)3.78296817
11cellular potassium ion homeostasis (GO:0030007)3.67728626
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.66549497
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.65312368
14regulation of ARF protein signal transduction (GO:0032012)3.63460949
15mannose metabolic process (GO:0006013)3.59815075
16cell communication by electrical coupling (GO:0010644)3.56074709
17retinal cone cell development (GO:0046549)3.54192111
18plasma membrane repair (GO:0001778)3.51369600
19negative regulation of potassium ion transmembrane transport (GO:1901380)3.49598835
20germinal center formation (GO:0002467)3.45858692
21potassium ion import (GO:0010107)3.44918452
22response to peptidoglycan (GO:0032494)3.40844184
23cardiac myofibril assembly (GO:0055003)3.39349298
24synaptic vesicle exocytosis (GO:0016079)3.37785736
25G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.32988251
26glutamate secretion (GO:0014047)3.29140813
27activation of protein kinase A activity (GO:0034199)3.27501696
28cellular extravasation (GO:0045123)3.26171511
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.19658910
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.19593130
31cardiac muscle contraction (GO:0060048)3.16187881
32regulation of synapse structural plasticity (GO:0051823)3.13832191
33sarcomere organization (GO:0045214)3.13137809
34regulation of synaptic vesicle exocytosis (GO:2000300)3.12984339
35positive regulation of histone deacetylation (GO:0031065)3.12139790
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.09894356
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08610713
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.08610713
39modulation by symbiont of host immune response (GO:0052553)3.08610713
40positive regulation by symbiont of host defense response (GO:0052509)3.08610713
41modulation by symbiont of host defense response (GO:0052031)3.08610713
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08610713
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.08067576
44regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.06794513
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05526572
46vocalization behavior (GO:0071625)3.04655847
47regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03234771
48regulation of gamma-delta T cell activation (GO:0046643)3.02659099
49positive regulation of Rap GTPase activity (GO:0032854)3.02237160
50regulation of rhodopsin mediated signaling pathway (GO:0022400)3.00783181
51regulation of clathrin-mediated endocytosis (GO:2000369)2.98654862
52regulation of glutamate receptor signaling pathway (GO:1900449)2.98631435
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98105241
54positive thymic T cell selection (GO:0045059)2.96829704
55rhodopsin mediated signaling pathway (GO:0016056)2.96442641
56regulation of calcium ion transmembrane transporter activity (GO:1901019)2.94720819
57regulation of calcium ion transmembrane transport (GO:1903169)2.94720819
58response to laminar fluid shear stress (GO:0034616)2.93713745
59antigen processing and presentation of endogenous antigen (GO:0019883)2.91763903
60cell communication involved in cardiac conduction (GO:0086065)2.89197521
61regulation of NFAT protein import into nucleus (GO:0051532)2.88955538
62myofibril assembly (GO:0030239)2.88675294
63negative regulation of cell size (GO:0045792)2.87934261
64macrophage activation involved in immune response (GO:0002281)2.87865819
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87672047
66regulation of membrane repolarization (GO:0060306)2.84317240
67regulation of synaptic vesicle transport (GO:1902803)2.83460641
68negative regulation of cell killing (GO:0031342)2.83189199
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83189199
70negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81002378
71cytoskeletal anchoring at plasma membrane (GO:0007016)2.80725685
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78185544
73layer formation in cerebral cortex (GO:0021819)2.78047135
74regulation of gamma-delta T cell differentiation (GO:0045586)2.77891280
75regulation of Rap GTPase activity (GO:0032317)2.76171466
76B cell receptor signaling pathway (GO:0050853)2.75683043
77stress fiber assembly (GO:0043149)2.75142013
78regulation of T-helper 2 cell differentiation (GO:0045628)2.74339881
79detection of other organism (GO:0098543)2.73868775
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.73867913
81sarcoplasmic reticulum calcium ion transport (GO:0070296)2.72749817
82positive regulation of myotube differentiation (GO:0010831)2.71174368
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70679203
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70527672
85exploration behavior (GO:0035640)2.70507008
86regulation of leukocyte degranulation (GO:0043300)2.70013074
87regulation of ARF GTPase activity (GO:0032312)2.69306313
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67522557
89striated muscle contraction (GO:0006941)2.66690380
90regulation of voltage-gated calcium channel activity (GO:1901385)2.65605113
91detection of bacterium (GO:0016045)2.64607033
92membrane repolarization (GO:0086009)2.64591989
93chemosensory behavior (GO:0007635)2.64555948
94neurotransmitter secretion (GO:0007269)2.63057003
95regulation of macrophage cytokine production (GO:0010935)2.62629712
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62113282
97protein localization to synapse (GO:0035418)2.61996897
98thymic T cell selection (GO:0045061)2.61430909
99regulation of B cell receptor signaling pathway (GO:0050855)2.61242364
100protein localization to endosome (GO:0036010)2.60821594
101regulation of cell communication by electrical coupling (GO:0010649)2.60476719
1023-UTR-mediated mRNA stabilization (GO:0070935)2.60257052
103regulation of necroptotic process (GO:0060544)2.59722904
104long-term memory (GO:0007616)2.59105646
105regulation of the force of heart contraction (GO:0002026)2.57430013
106negative regulation of toll-like receptor signaling pathway (GO:0034122)2.57015015
107cerebellar Purkinje cell differentiation (GO:0021702)2.56720844
108cell-substrate adherens junction assembly (GO:0007045)2.56185200
109focal adhesion assembly (GO:0048041)2.56185200
110cellular sodium ion homeostasis (GO:0006883)2.56010218
111membrane depolarization during action potential (GO:0086010)2.55617733
112positive regulation of gamma-delta T cell activation (GO:0046645)2.55083513
113potassium ion homeostasis (GO:0055075)2.54221949
114positive regulation of protein dephosphorylation (GO:0035307)2.53926054
115retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53441092
116positive regulation of sodium ion transport (GO:0010765)2.53188595
117actin-myosin filament sliding (GO:0033275)2.52988687
118muscle filament sliding (GO:0030049)2.52988687
119skeletal muscle contraction (GO:0003009)2.52153984
120regulation of neuronal synaptic plasticity (GO:0048168)2.51218656
121regulation of mast cell degranulation (GO:0043304)2.51164219
122regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50909017
123negative regulation of necroptotic process (GO:0060546)2.49402090
124B cell homeostasis (GO:0001782)2.48793294
125adaptation of signaling pathway (GO:0023058)2.48348350
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.48259372
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.47416334
128negative regulation of potassium ion transport (GO:0043267)2.46828296
129regulation of regulated secretory pathway (GO:1903305)2.46586080
130regulation of cation channel activity (GO:2001257)2.46529513
131positive regulation of synapse maturation (GO:0090129)2.45965421
132positive regulation of membrane potential (GO:0045838)2.45590650
133cellular response to epinephrine stimulus (GO:0071872)2.45567220
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.44413276
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.43966615
136proline transport (GO:0015824)2.43477531
137regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.42987799
138neutrophil activation involved in immune response (GO:0002283)2.41858770
139T cell selection (GO:0045058)2.41258593
140neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.41012205
141cellular response to fluid shear stress (GO:0071498)2.40158704
142regulation of postsynaptic membrane potential (GO:0060078)2.39024539
143peptidyl-threonine phosphorylation (GO:0018107)2.38753240
144embryonic process involved in female pregnancy (GO:0060136)2.37441837
145positive regulation of guanylate cyclase activity (GO:0031284)2.37346346
146negative thymic T cell selection (GO:0045060)2.37047645
147dendritic spine morphogenesis (GO:0060997)2.36878520
148adherens junction assembly (GO:0034333)2.35946029
149negative regulation of type 2 immune response (GO:0002829)2.35893941
150positive regulation of cation channel activity (GO:2001259)2.35878462
151negative regulation of myotube differentiation (GO:0010832)2.35727722
152protein targeting to Golgi (GO:0000042)2.35641897
153regulation of ion transmembrane transporter activity (GO:0032412)2.35445103
154regulation of sodium ion transport (GO:0002028)2.35339689
155signal complex assembly (GO:0007172)2.35127038
156positive T cell selection (GO:0043368)2.33713642
157detection of external biotic stimulus (GO:0098581)2.28882367
158negative regulation of leukocyte mediated immunity (GO:0002704)2.26089586
159leukocyte aggregation (GO:0070486)2.25862860
160pinocytosis (GO:0006907)2.25819611
161negative regulation of interleukin-8 production (GO:0032717)2.25783474
162negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.22079329
163response to fluid shear stress (GO:0034405)2.21929061
164response to host (GO:0075136)2.21921914
165response to host defenses (GO:0052200)2.21921914
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.21921914
167histone H3-K36 demethylation (GO:0070544)2.21308723
168lipopolysaccharide-mediated signaling pathway (GO:0031663)2.21122120
169tolerance induction (GO:0002507)2.20886108
170negative regulation of granulocyte differentiation (GO:0030853)2.20533070
171detection of molecule of bacterial origin (GO:0032490)2.20521603
172positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18162621
173regulation of mast cell activation involved in immune response (GO:0033006)2.17811520
174negative regulation of T cell mediated immunity (GO:0002710)2.16246947
175negative regulation of lymphocyte mediated immunity (GO:0002707)2.16065776
176negative T cell selection (GO:0043383)2.15911849
177positive regulation of B cell differentiation (GO:0045579)2.15873835
178regulation of necrotic cell death (GO:0010939)2.15252282
179regulation of interferon-beta biosynthetic process (GO:0045357)2.14894689
180neutrophil mediated immunity (GO:0002446)2.14495352
181activation of JUN kinase activity (GO:0007257)2.13864769
182activation of MAPKKK activity (GO:0000185)2.12155536
183regulation of lipid kinase activity (GO:0043550)2.11910352
184positive regulation of fibroblast migration (GO:0010763)2.10321548
185regulation of early endosome to late endosome transport (GO:2000641)2.10094866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.95389977
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.87255795
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.86213849
4* MYC_22102868_ChIP-Seq_BL_Human2.83202735
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83121074
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.69692922
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61468527
8* KDM2B_26808549_Chip-Seq_DND41_Human2.60323985
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56681992
10DROSHA_22980978_ChIP-Seq_HELA_Human2.52888810
11TCF7_22412390_ChIP-Seq_EML_Mouse2.34710956
12KDM2B_26808549_Chip-Seq_K562_Human2.23984599
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12382723
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07272834
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02322414
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98892227
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97530988
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95199636
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94848793
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93568836
21KDM2B_26808549_Chip-Seq_JURKAT_Human1.92695676
22* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.90403738
23* LXR_22292898_ChIP-Seq_THP-1_Human1.88530325
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88238042
25* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.88177299
26* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84699729
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83069718
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82805429
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81483434
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80494529
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77988309
32* IRF8_22096565_ChIP-ChIP_GC-B_Human1.76532357
33* VDR_21846776_ChIP-Seq_THP-1_Human1.76007361
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74774025
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73783333
36* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73148275
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68482952
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66978119
39RUNX_20019798_ChIP-Seq_JUKART_Human1.66967608
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66708243
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65744642
42SPI1_23127762_ChIP-Seq_K562_Human1.65723789
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.61145260
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58269392
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55342361
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54994989
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52053482
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52053482
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.51571869
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50150718
51* MAF_26560356_Chip-Seq_TH2_Human1.49818200
52* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49267071
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48885050
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46879830
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44902225
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42245874
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40067603
58* TBX20_22080862_ChIP-Seq_HEART_Mouse1.39158283
59* TBX20_22328084_ChIP-Seq_HEART_Mouse1.39158283
60* IRF8_27001747_Chip-Seq_BMDM_Mouse1.39050723
61REST_21632747_ChIP-Seq_MESCs_Mouse1.38309968
62* UTX_26944678_Chip-Seq_JUKART_Human1.38208868
63MAF_26560356_Chip-Seq_TH1_Human1.35887977
64* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34253764
65* REST_18959480_ChIP-ChIP_MESCs_Mouse1.32907039
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29571226
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29091828
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29048457
69* CREB1_26743006_Chip-Seq_LNCaP_Human1.28204075
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27759536
71SMC4_20622854_ChIP-Seq_HELA_Human1.27729391
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27420609
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.27067701
74* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26876427
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26842756
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26638986
77SCL_19346495_ChIP-Seq_HPC-7_Human1.26488048
78* GATA1_19941827_ChIP-Seq_MEL_Mouse1.26336778
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.23450595
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23246430
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.22450511
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.21870094
83CLOCK_20551151_ChIP-Seq_293T_Human1.19868462
84VDR_24787735_ChIP-Seq_THP-1_Human1.19341702
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18244737
86RACK7_27058665_Chip-Seq_MCF-7_Human1.18069724
87* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17362673
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15965341
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14502340
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14271750
91* GATA1_19941826_ChIP-Seq_K562_Human1.13970444
92* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13956511
93* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13553204
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13439321
95* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12871766
96P68_20966046_ChIP-Seq_HELA_Human1.11192520
97ZNF263_19887448_ChIP-Seq_K562_Human1.10705821
98AR_21572438_ChIP-Seq_LNCaP_Human1.10550928
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10531054
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.09725965
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08531836
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07970635
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07765626
104MYB_26560356_Chip-Seq_TH1_Human1.07715960
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07527879
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06781017
107* VDR_24763502_ChIP-Seq_THP-1_Human1.06700081
108MYB_26560356_Chip-Seq_TH2_Human1.06475717
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05901760
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05460131
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.05357023
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04804447
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04381150
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04289625
115* AR_19668381_ChIP-Seq_PC3_Human1.02328895
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02274026
117* CTCF_27219007_Chip-Seq_Bcells_Human1.02217510
118SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01852799
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01643026
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01200088
121TP63_17297297_ChIP-ChIP_HaCaT_Human0.99777761
122* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98484755
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97278406
124* NCOR1_26117541_ChIP-Seq_K562_Human0.97268639
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95626504
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95061460
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94312368
128* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93963540
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92568548
130* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91654023
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91038854
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.90949815
133OCT4_19829295_ChIP-Seq_ESCs_Human0.90026709
134* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89776525
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.88741397
136AHR_22903824_ChIP-Seq_MCF-7_Human0.88532568
137* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88040408
138* TP63_22573176_ChIP-Seq_HFKS_Human0.87691611
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.87284314
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87137115
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.86480972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.72521442
2MP0000751_myopathy3.29742977
3MP0003436_decreased_susceptibility_to3.05684850
4MP0003646_muscle_fatigue2.88680527
5MP0008961_abnormal_basal_metabolism2.87579916
6MP0002837_dystrophic_cardiac_calcinosis2.77717472
7MP0005551_abnormal_eye_electrophysiolog2.66326839
8MP0004084_abnormal_cardiac_muscle2.63929132
9MP0005451_abnormal_body_composition2.63645437
10MP0003635_abnormal_synaptic_transmissio2.50162226
11MP0000749_muscle_degeneration2.36453881
12MP0004036_abnormal_muscle_relaxation2.34630206
13MP0004510_myositis2.31800303
14MP0004270_analgesia2.25541336
15MP0002909_abnormal_adrenal_gland2.22502171
16MP0004215_abnormal_myocardial_fiber2.17714886
17MP0004145_abnormal_muscle_electrophysio2.15257795
18MP0004130_abnormal_muscle_cell2.07683452
19MP0005058_abnormal_lysosome_morphology2.05851810
20MP0004233_abnormal_muscle_weight2.05216324
21* MP0004087_abnormal_muscle_fiber2.04274722
22MP0009780_abnormal_chondrocyte_physiolo1.99318330
23MP0002822_catalepsy1.98211564
24MP0001835_abnormal_antigen_presentation1.94121814
25MP0005330_cardiomyopathy1.87809318
26MP0002419_abnormal_innate_immunity1.86729541
27MP0008569_lethality_at_weaning1.84417155
28MP0003763_abnormal_thymus_physiology1.84017835
29MP0000685_abnormal_immune_system1.82791708
30MP0000747_muscle_weakness1.79920692
31MP0005423_abnormal_somatic_nervous1.76045611
32MP0008260_abnormal_autophagy1.75546450
33MP0002063_abnormal_learning/memory/cond1.72966561
34MP0002064_seizures1.70793124
35MP0003303_peritoneal_inflammation1.70173253
36MP0005000_abnormal_immune_tolerance1.69375714
37MP0009745_abnormal_behavioral_response1.68744835
38MP0002106_abnormal_muscle_physiology1.67154668
39MP0004947_skin_inflammation1.66804143
40MP0003724_increased_susceptibility_to1.66622766
41MP0004484_altered_response_of1.66367596
42MP0003091_abnormal_cell_migration1.66248469
43MP0001800_abnormal_humoral_immune1.64431355
44MP0005387_immune_system_phenotype1.63506255
45MP0001790_abnormal_immune_system1.63506255
46MP0006072_abnormal_retinal_apoptosis1.62533314
47MP0005025_abnormal_response_to1.62298103
48MP0002998_abnormal_bone_remodeling1.57798347
49MP0002269_muscular_atrophy1.56245378
50* MP0000759_abnormal_skeletal_muscle1.52406955
51MP0003191_abnormal_cellular_cholesterol1.51629238
52MP0000750_abnormal_muscle_regeneration1.49997201
53MP0003279_aneurysm1.49735968
54MP0005253_abnormal_eye_physiology1.48004140
55MP0004085_abnormal_heartbeat1.47956316
56MP0002396_abnormal_hematopoietic_system1.47791872
57* MP0005620_abnormal_muscle_contractility1.47547612
58* MP0010630_abnormal_cardiac_muscle1.46969733
59MP0005409_darkened_coat_color1.46417548
60MP0002420_abnormal_adaptive_immunity1.46310447
61MP0002090_abnormal_vision1.44703543
62MP0009840_abnormal_foam_cell1.44549629
63MP0003011_delayed_dark_adaptation1.44425863
64MP0001533_abnormal_skeleton_physiology1.44115651
65MP0002723_abnormal_immune_serum1.43520765
66MP0001819_abnormal_immune_cell1.43337805
67MP0003045_fibrosis1.42589332
68MP0002009_preneoplasia1.42387254
69MP0009046_muscle_twitch1.41748386
70MP0002452_abnormal_antigen_presenting1.41004518
71MP0005464_abnormal_platelet_physiology1.36945432
72MP0003300_gastrointestinal_ulcer1.36408054
73MP0002572_abnormal_emotion/affect_behav1.35882485
74MP0001958_emphysema1.32937283
75MP0001851_eye_inflammation1.32778814
76* MP0002972_abnormal_cardiac_muscle1.32754910
77MP0005369_muscle_phenotype1.31510523
78MP0003566_abnormal_cell_adhesion1.29683903
79MP0003137_abnormal_impulse_conducting1.24330671
80MP0002398_abnormal_bone_marrow1.23216053
81MP0004858_abnormal_nervous_system1.22493463
82MP0004185_abnormal_adipocyte_glucose1.22145909
83MP0003705_abnormal_hypodermis_morpholog1.19328699
84MP0000013_abnormal_adipose_tissue1.17585116
85MP0005166_decreased_susceptibility_to1.17305673
86MP0000716_abnormal_immune_system1.16230300
87MP0008438_abnormal_cutaneous_collagen1.14249911
88MP0008775_abnormal_heart_ventricle1.13776002
89MP0001544_abnormal_cardiovascular_syste1.13220878
90MP0005385_cardiovascular_system_phenoty1.13220878
91MP0000003_abnormal_adipose_tissue1.11876751
92MP0002272_abnormal_nervous_system1.11212602
93MP0002933_joint_inflammation1.09815888
94MP0003690_abnormal_glial_cell1.08657273
95MP0001486_abnormal_startle_reflex1.08448384
96MP0001968_abnormal_touch/_nociception1.06440024
97MP0003880_abnormal_central_pattern1.04626113
98MP0004811_abnormal_neuron_physiology1.04563058
99MP0002405_respiratory_system_inflammati1.04546498
100MP0005375_adipose_tissue_phenotype1.04412098
101MP0010155_abnormal_intestine_physiology1.04140036
102MP0008874_decreased_physiological_sensi1.04130439
103MP0003075_altered_response_to1.03903853
104MP0001501_abnormal_sleep_pattern1.03380662
105MP0003828_pulmonary_edema1.03328207
106MP0005671_abnormal_response_to1.03304939
107MP0002148_abnormal_hypersensitivity_rea1.00976102
108MP0005076_abnormal_cell_differentiation0.99386568
109MP0000733_abnormal_muscle_development0.99021639
110MP0004381_abnormal_hair_follicle0.98833390
111MP0002229_neurodegeneration0.98223181
112MP0001545_abnormal_hematopoietic_system0.97616535
113MP0005397_hematopoietic_system_phenotyp0.97616535
114MP0004808_abnormal_hematopoietic_stem0.97561072
115MP0000569_abnormal_digit_pigmentation0.97455768
116MP0001853_heart_inflammation0.97156580
117MP0001348_abnormal_lacrimal_gland0.96365754
118MP0000604_amyloidosis0.96084477
119MP0005386_behavior/neurological_phenoty0.95830038
120MP0004924_abnormal_behavior0.95830038
121MP0003633_abnormal_nervous_system0.93845558
122MP0002734_abnormal_mechanical_nocicepti0.93030799
123MP0009333_abnormal_splenocyte_physiolog0.91993615
124MP0003879_abnormal_hair_cell0.91672903
125MP0006082_CNS_inflammation0.90991661
126MP0004885_abnormal_endolymph0.90396723
127MP0002722_abnormal_immune_system0.90364204
128MP0002429_abnormal_blood_cell0.90200294
129MP0000767_abnormal_smooth_muscle0.89761791
130MP0005666_abnormal_adipose_tissue0.89577365
131MP0003172_abnormal_lysosome_physiology0.89436222
132MP0003950_abnormal_plasma_membrane0.89412210
133MP0000858_altered_metastatic_potential0.89072162
134MP0009785_altered_susceptibility_to0.88859481
135MP0001502_abnormal_circadian_rhythm0.85805596
136MP0003453_abnormal_keratinocyte_physiol0.85529567
137MP0002127_abnormal_cardiovascular_syste0.84103274
138MP0006138_congestive_heart_failure0.84067518
139MP0002234_abnormal_pharynx_morphology0.83772133
140MP0002067_abnormal_sensory_capabilities0.83600371
141MP0009278_abnormal_bone_marrow0.83561880
142MP0002882_abnormal_neuron_morphology0.81086332
143MP0010234_abnormal_vibrissa_follicle0.77637993
144MP0003329_amyloid_beta_deposits0.77608435
145MP0001970_abnormal_pain_threshold0.74984065
146MP0005195_abnormal_posterior_eye0.74153890
147MP0000703_abnormal_thymus_morphology0.72707732
148* MP0000266_abnormal_heart_morphology0.72628006
149MP0002332_abnormal_exercise_endurance0.71624577
150MP0002877_abnormal_melanocyte_morpholog0.71076892
151MP0002166_altered_tumor_susceptibility0.70339276
152MP0001440_abnormal_grooming_behavior0.70132059
153MP0003787_abnormal_imprinting0.69841433
154MP0002066_abnormal_motor_capabilities/c0.67068467
155MP0005623_abnormal_meninges_morphology0.65540725
156MP0010352_gastrointestinal_tract_polyps0.63743442

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.58097349
2Central scotoma (HP:0000603)4.32603785
3Nemaline bodies (HP:0003798)4.03639790
4Exercise-induced myalgia (HP:0003738)3.91526979
5Sudden death (HP:0001699)3.88510312
6Bony spicule pigmentary retinopathy (HP:0007737)3.77946970
7Obstructive sleep apnea (HP:0002870)3.61606752
8Scotoma (HP:0000575)3.51465672
9Dysmetric saccades (HP:0000641)3.51281357
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.33124825
11Exercise-induced muscle cramps (HP:0003710)3.30110890
12Dyschromatopsia (HP:0007641)3.26004940
13Visual hallucinations (HP:0002367)3.21545557
14Distal lower limb muscle weakness (HP:0009053)3.18260592
15Bundle branch block (HP:0011710)3.14951515
16Difficulty running (HP:0009046)3.14947782
17Abnormal rod and cone electroretinograms (HP:0008323)3.03894933
18Eczematoid dermatitis (HP:0000976)3.01692777
19Hyporeflexia of lower limbs (HP:0002600)2.98659600
20Ventricular fibrillation (HP:0001663)2.96943092
21Calf muscle hypertrophy (HP:0008981)2.95622305
22Abnormality of macular pigmentation (HP:0008002)2.93635034
23Atrial fibrillation (HP:0005110)2.89885296
24Prolonged QT interval (HP:0001657)2.85030093
25Primary atrial arrhythmia (HP:0001692)2.81137532
26Round ear (HP:0100830)2.76379240
27Muscle hypertrophy of the lower extremities (HP:0008968)2.75402421
28Pigmentary retinal degeneration (HP:0001146)2.74834095
29Abnormality of the calf musculature (HP:0001430)2.72817391
30Myokymia (HP:0002411)2.72751573
31Macroorchidism (HP:0000053)2.72123868
32Subaortic stenosis (HP:0001682)2.69659482
33Abnormality of the left ventricular outflow tract (HP:0011103)2.69659482
34Myopathic facies (HP:0002058)2.69480125
35Ulnar deviation of the wrist (HP:0003049)2.65665556
36Focal motor seizures (HP:0011153)2.65358122
37Focal seizures (HP:0007359)2.65094353
38Supraventricular tachycardia (HP:0004755)2.64421538
39Supraventricular arrhythmia (HP:0005115)2.58744186
40EMG: myopathic abnormalities (HP:0003458)2.54281910
41Syncope (HP:0001279)2.53128371
42Muscle fiber splitting (HP:0003555)2.49442682
43Asymmetric septal hypertrophy (HP:0001670)2.46862514
44Genetic anticipation (HP:0003743)2.44048803
45Ventricular tachycardia (HP:0004756)2.43852536
46Papilloma (HP:0012740)2.42902559
47Verrucae (HP:0200043)2.42902559
48Abnormal EKG (HP:0003115)2.40181349
49Myotonia (HP:0002486)2.37046584
50Increased IgE level (HP:0003212)2.37014862
51Hyperacusis (HP:0010780)2.34806954
52Distal arthrogryposis (HP:0005684)2.33323819
53Type 1 muscle fiber predominance (HP:0003803)2.31718043
54Depression (HP:0000716)2.30534148
55Increased variability in muscle fiber diameter (HP:0003557)2.28540660
56Abnormality of the fingertips (HP:0001211)2.28408914
57Lower limb amyotrophy (HP:0007210)2.26309201
58Pendular nystagmus (HP:0012043)2.26218355
59Frequent falls (HP:0002359)2.24424210
60Spontaneous hematomas (HP:0007420)2.24336669
61Abnormal social behavior (HP:0012433)2.22982835
62Impaired social interactions (HP:0000735)2.22982835
63Myoglobinuria (HP:0002913)2.21341469
64Posterior subcapsular cataract (HP:0007787)2.20871649
65Broad face (HP:0000283)2.19303580
66Increased connective tissue (HP:0009025)2.17973918
67Abnormality of binocular vision (HP:0011514)2.17757843
68Diplopia (HP:0000651)2.17757843
69Recurrent abscess formation (HP:0002722)2.17747741
70Difficulty climbing stairs (HP:0003551)2.17575985
71Abnormality of macrophages (HP:0004311)2.17404499
72Abnormality of the lower motor neuron (HP:0002366)2.16869747
73Postural instability (HP:0002172)2.15675650
74Abnormality of skeletal muscle fiber size (HP:0012084)2.15613473
75Heart block (HP:0012722)2.14215644
76Neck muscle weakness (HP:0000467)2.13754351
77Ventricular arrhythmia (HP:0004308)2.13515266
78Cerebral aneurysm (HP:0004944)2.13369833
79Recurrent bacterial skin infections (HP:0005406)2.12277560
80Papilledema (HP:0001085)2.11874120
81Rapidly progressive (HP:0003678)2.11136553
82Truncal ataxia (HP:0002078)2.10846738
83Vertebral arch anomaly (HP:0008438)2.10793155
84Amyloidosis (HP:0011034)2.09934131
85Epileptic encephalopathy (HP:0200134)2.08632587
86Spondylolisthesis (HP:0003302)2.08208199
87Action tremor (HP:0002345)2.07763494
88Atrioventricular block (HP:0001678)2.07025510
89Colitis (HP:0002583)2.06436836
90Dysdiadochokinesis (HP:0002075)2.06086360
91Distal lower limb amyotrophy (HP:0008944)2.05816342
92Chorioretinal atrophy (HP:0000533)2.05410735
93Poor eye contact (HP:0000817)2.04925390
94Hemiplegia (HP:0002301)2.02586069
95EMG: neuropathic changes (HP:0003445)2.02437296
96Dysostosis multiplex (HP:0000943)2.01498035
97Abnormal atrioventricular conduction (HP:0005150)2.01420850
98Neoplasm of the heart (HP:0100544)1.99843867
99Bulbar palsy (HP:0001283)1.98052975
100Type II diabetes mellitus (HP:0005978)1.97647125
101Supranuclear gaze palsy (HP:0000605)1.97055027
102Aortic aneurysm (HP:0004942)1.95991145
103Foot dorsiflexor weakness (HP:0009027)1.95525911
104Protrusio acetabuli (HP:0003179)1.95498257
105Myositis (HP:0100614)1.94605990
106Distal upper limb amyotrophy (HP:0007149)1.94576152
107Upper limb amyotrophy (HP:0009129)1.94576152
108Elevated erythrocyte sedimentation rate (HP:0003565)1.94460382
109Muscle stiffness (HP:0003552)1.94373550
110Urinary bladder sphincter dysfunction (HP:0002839)1.93174384
111Impaired smooth pursuit (HP:0007772)1.91533033
112Slow saccadic eye movements (HP:0000514)1.91225241
113Mildly elevated creatine phosphokinase (HP:0008180)1.90099336
114Pointed chin (HP:0000307)1.89784381
115Progressive cerebellar ataxia (HP:0002073)1.89092358
116Cellulitis (HP:0100658)1.88720680
117Neuronal loss in central nervous system (HP:0002529)1.88491087
118Broad-based gait (HP:0002136)1.87265290
119Muscle fiber inclusion bodies (HP:0100299)1.86915421
120Fatigue (HP:0012378)1.86556348
121Slender build (HP:0001533)1.86039113
122Febrile seizures (HP:0002373)1.85726511
123Absence seizures (HP:0002121)1.85582640
124Gastrointestinal stroma tumor (HP:0100723)1.85240413
125Agammaglobulinemia (HP:0004432)1.85048515
126Abnormality of the foot musculature (HP:0001436)1.84961659
127Rhabdomyolysis (HP:0003201)1.84518235
128Limb-girdle muscle atrophy (HP:0003797)1.84443149
129Aneurysm (HP:0002617)1.84442530
130Interstitial pulmonary disease (HP:0006530)1.83966721
131Meningitis (HP:0001287)1.82960791
132Achilles tendon contracture (HP:0001771)1.82634302
133Gingivitis (HP:0000230)1.81777877
134Ankle clonus (HP:0011448)1.81403808
135Mediastinal lymphadenopathy (HP:0100721)1.81359506
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80867227
137Easy fatigability (HP:0003388)1.78597008
138Chest pain (HP:0100749)1.77901596
139Recurrent fungal infections (HP:0002841)1.77749778
140Hypercortisolism (HP:0001578)1.77546694
141Gastrointestinal inflammation (HP:0004386)1.77148934
142Annular pancreas (HP:0001734)1.74391012
143Enlarged penis (HP:0000040)1.73341403
144Increased cerebral lipofuscin (HP:0011813)1.72608954
145Centrally nucleated skeletal muscle fibers (HP:0003687)1.71625954
146Abnormality of ocular smooth pursuit (HP:0000617)1.71263133
147Emphysema (HP:0002097)1.70745710
148Inflammation of the large intestine (HP:0002037)1.70448999
149Prolonged bleeding time (HP:0003010)1.69959138
150Onion bulb formation (HP:0003383)1.69504526
151Segmental peripheral demyelination/remyelination (HP:0003481)1.68640165
152Recurrent gram-negative bacterial infections (HP:0005420)1.68080539
153Recurrent cutaneous fungal infections (HP:0011370)1.66597639
154Chronic mucocutaneous candidiasis (HP:0002728)1.66597639
155Dilatation of the ascending aorta (HP:0005111)1.66026253
156Abnormal delayed hypersensitivity skin test (HP:0002963)1.65742986
157Polycythemia (HP:0001901)1.65467234
158Restrictive lung disease (HP:0002091)1.65297054
159Polygenic inheritance (HP:0010982)1.65282063
160Spinal rigidity (HP:0003306)1.64815514
161Recurrent viral infections (HP:0004429)1.64583048
162Neurofibrillary tangles (HP:0002185)1.63069380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.40069997
2MAP3K103.34083568
3PKN22.71373501
4MAP3K92.40683765
5SIK22.29753505
6EEF2K2.25850404
7TTN2.17264663
8DMPK2.11018599
9ERN12.09006822
10CDK122.00579029
11TAOK11.99433206
12PRKD31.93483461
13NTRK31.88783166
14MAP4K11.88736033
15CAMKK11.85947621
16MAP3K71.84858629
17RIPK11.77286342
18KSR21.60147163
19PRKCH1.56049582
20EPHA41.55563444
21CAMK1G1.54788404
22PAK61.53138363
23PHKG21.49780894
24PHKG11.49780894
25GRK61.39934857
26TYK21.39009446
27STK381.37831058
28MAP3K141.32714534
29BLK1.32552329
30ALK1.32531920
31SMG11.32482183
32DAPK21.27102371
33MARK21.25928889
34FES1.25821697
35TBK11.24760964
36PIK3CG1.24264976
37MAP3K41.18142054
38TYRO31.15588265
39MAP3K31.15267531
40MAP3K131.14693318
41RIPK41.13832124
42TAOK21.13425478
43CAMK11.13114779
44SGK31.11554462
45CAMK1D1.05105575
46PDK11.04680386
47CAMK41.03024952
48RET1.02300582
49STK111.00194901
50LMTK20.99285948
51HIPK20.98800504
52PRKD20.98510932
53IRAK40.98411212
54ICK0.95840443
55KIT0.92757134
56MAP3K110.92322742
57OBSCN0.92110680
58MINK10.90266983
59MAP2K40.88722473
60MOS0.88291489
61CSK0.87948005
62PRKD10.87929986
63WNK10.87013992
64NTRK20.87002587
65IRAK30.86235435
66MAP3K10.85875715
67CDC42BPA0.84464413
68FGFR30.82610864
69GRK10.81999581
70SIK10.80142532
71TRPM70.79777322
72* MAPK70.78646301
73FGFR40.77641385
74PDGFRA0.76830999
75NEK10.76596883
76BTK0.76588889
77TNK20.76194228
78IRAK20.75841260
79SYK0.74581777
80JAK10.74328874
81PDPK10.74088183
82PTK60.72444961
83IKBKE0.71360053
84HCK0.70337327
85* CDK50.68075045
86GRK50.67634661
87ARAF0.67326788
88MAPK110.66423537
89MAP3K60.66391962
90JAK30.65621473
91MAP3K20.64227164
92MAPK40.64157761
93PINK10.63743758
94RPS6KC10.63713287
95RPS6KL10.63713287
96MAP2K30.63021820
97NTRK10.62210884
98PRPF4B0.61998457
99CAMKK20.60909608
100PAK30.59557076
101LRRK20.59488233
102KSR10.57831772
103DAPK10.56729734
104MTOR0.56068856
105PTK2B0.55538940
106PDGFRB0.55107401
107SGK10.53206426
108ITK0.53099144
109SGK20.52949841
110DYRK1B0.50958924
111RPS6KA20.49647732
112LATS20.49615368
113TGFBR20.49442413
114MARK30.48121157
115UHMK10.48105579
116PRKAA10.48020244
117SGK4940.47209885
118SGK2230.47209885
119* MAPK120.47081047
120RPS6KA60.45709613
121FYN0.44653140
122* RPS6KA30.44559452
123ZAP700.44345630
124BMX0.44276333
125RAF10.43506053
126NEK90.42510702
127JAK20.42335820
128BRD40.42213446
129EPHB10.41016527
130SCYL20.40653671
131FGFR20.39054348
132MAPK100.36627394
133SIK30.35558161
134CSF1R0.35029180

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.56554446
2Olfactory transduction_Homo sapiens_hsa047402.16501932
3Long-term potentiation_Homo sapiens_hsa047201.89877026
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85800369
5Circadian entrainment_Homo sapiens_hsa047131.84951987
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82399431
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80338125
8Dilated cardiomyopathy_Homo sapiens_hsa054141.79434377
9Other glycan degradation_Homo sapiens_hsa005111.71162879
10Synaptic vesicle cycle_Homo sapiens_hsa047211.70413012
11Oxytocin signaling pathway_Homo sapiens_hsa049211.60410782
12Gastric acid secretion_Homo sapiens_hsa049711.59457340
13Insulin secretion_Homo sapiens_hsa049111.59357075
14Morphine addiction_Homo sapiens_hsa050321.55614792
15Glutamatergic synapse_Homo sapiens_hsa047241.53410291
16Salivary secretion_Homo sapiens_hsa049701.51747493
17Cholinergic synapse_Homo sapiens_hsa047251.51205933
18GABAergic synapse_Homo sapiens_hsa047271.50724165
19Leishmaniasis_Homo sapiens_hsa051401.49641915
20Type II diabetes mellitus_Homo sapiens_hsa049301.46681386
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44873103
22Amphetamine addiction_Homo sapiens_hsa050311.40728817
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40074913
24Dopaminergic synapse_Homo sapiens_hsa047281.39817795
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38047599
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34582723
27B cell receptor signaling pathway_Homo sapiens_hsa046621.34193324
28Renin secretion_Homo sapiens_hsa049241.33237864
29Glioma_Homo sapiens_hsa052141.31430906
30* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30209411
31mTOR signaling pathway_Homo sapiens_hsa041501.28847104
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28333643
33GnRH signaling pathway_Homo sapiens_hsa049121.26184859
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26044334
35Calcium signaling pathway_Homo sapiens_hsa040201.22498299
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21686355
37Tuberculosis_Homo sapiens_hsa051521.20169038
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18624793
39Nicotine addiction_Homo sapiens_hsa050331.16964897
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15932728
41cAMP signaling pathway_Homo sapiens_hsa040241.14080516
42Cardiac muscle contraction_Homo sapiens_hsa042601.13816886
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12890271
44VEGF signaling pathway_Homo sapiens_hsa043701.12602989
45Notch signaling pathway_Homo sapiens_hsa043301.10893760
46Non-small cell lung cancer_Homo sapiens_hsa052231.09516785
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.09230092
48Toxoplasmosis_Homo sapiens_hsa051451.09012367
49TNF signaling pathway_Homo sapiens_hsa046681.07532238
50Estrogen signaling pathway_Homo sapiens_hsa049151.06484771
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05013727
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01257356
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00950546
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.00923363
55Hepatitis B_Homo sapiens_hsa051611.00843224
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00521605
57Influenza A_Homo sapiens_hsa051640.99617950
58Amoebiasis_Homo sapiens_hsa051460.99567698
59Cocaine addiction_Homo sapiens_hsa050300.99217170
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.98619227
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96610255
62Chronic myeloid leukemia_Homo sapiens_hsa052200.94453572
63Dorso-ventral axis formation_Homo sapiens_hsa043200.94258177
64Primary immunodeficiency_Homo sapiens_hsa053400.94249363
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94229374
66Insulin resistance_Homo sapiens_hsa049310.94216238
67Glucagon signaling pathway_Homo sapiens_hsa049220.94021921
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92551046
69Long-term depression_Homo sapiens_hsa047300.92124643
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91907872
71ErbB signaling pathway_Homo sapiens_hsa040120.91710429
72Insulin signaling pathway_Homo sapiens_hsa049100.90754310
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89698489
74MAPK signaling pathway_Homo sapiens_hsa040100.89658719
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.88208459
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.88128760
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87959519
78Gap junction_Homo sapiens_hsa045400.87616861
79Pancreatic secretion_Homo sapiens_hsa049720.87592353
80T cell receptor signaling pathway_Homo sapiens_hsa046600.86292005
81Malaria_Homo sapiens_hsa051440.84931483
82Staphylococcus aureus infection_Homo sapiens_hsa051500.83709368
83Platelet activation_Homo sapiens_hsa046110.83454520
84Hepatitis C_Homo sapiens_hsa051600.81500123
85Osteoclast differentiation_Homo sapiens_hsa043800.81475101
86Prion diseases_Homo sapiens_hsa050200.80778888
87Acute myeloid leukemia_Homo sapiens_hsa052210.80048814
88Choline metabolism in cancer_Homo sapiens_hsa052310.79452640
89Renal cell carcinoma_Homo sapiens_hsa052110.79127372
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78208393
91Measles_Homo sapiens_hsa051620.78064858
92Inositol phosphate metabolism_Homo sapiens_hsa005620.77681682
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77659075
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.77565907
95Endometrial cancer_Homo sapiens_hsa052130.77534652
96HIF-1 signaling pathway_Homo sapiens_hsa040660.75648928
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.75622432
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75355889
99Chemokine signaling pathway_Homo sapiens_hsa040620.75194898
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74477186
101Circadian rhythm_Homo sapiens_hsa047100.74424377
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74398792
103Bladder cancer_Homo sapiens_hsa052190.74177292
104Pertussis_Homo sapiens_hsa051330.73470691
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.73466698
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.72827434
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71098276
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69639810
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.69147719
110Melanogenesis_Homo sapiens_hsa049160.67085266
111Apoptosis_Homo sapiens_hsa042100.67048196
112Nitrogen metabolism_Homo sapiens_hsa009100.66973025
113Graft-versus-host disease_Homo sapiens_hsa053320.66915771
114Serotonergic synapse_Homo sapiens_hsa047260.66483018
115Allograft rejection_Homo sapiens_hsa053300.65799602
116Taste transduction_Homo sapiens_hsa047420.65281271
117Prostate cancer_Homo sapiens_hsa052150.64737825
118Endocytosis_Homo sapiens_hsa041440.63994292
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63943921
120AMPK signaling pathway_Homo sapiens_hsa041520.63752055
121Autoimmune thyroid disease_Homo sapiens_hsa053200.63255735
122Proteoglycans in cancer_Homo sapiens_hsa052050.62503312
123Lysine degradation_Homo sapiens_hsa003100.62334294
124Focal adhesion_Homo sapiens_hsa045100.62149274
125Rap1 signaling pathway_Homo sapiens_hsa040150.61373942
126Viral myocarditis_Homo sapiens_hsa054160.59520447
127Pancreatic cancer_Homo sapiens_hsa052120.57362907
128FoxO signaling pathway_Homo sapiens_hsa040680.56625937
129Prolactin signaling pathway_Homo sapiens_hsa049170.56501053
130Thyroid hormone synthesis_Homo sapiens_hsa049180.56191622
131Colorectal cancer_Homo sapiens_hsa052100.55844300
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55199008
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55022887

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