MEGF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.55098849
2central nervous system myelination (GO:0022010)8.55098849
3myelination (GO:0042552)4.56195873
4axon ensheathment (GO:0008366)4.54813382
5ensheathment of neurons (GO:0007272)4.54813382
6L-amino acid import (GO:0043092)4.33688133
7establishment of nucleus localization (GO:0040023)3.96839065
8negative regulation of protein localization to cell surface (GO:2000009)3.94090311
9myelin maintenance (GO:0043217)3.92332670
10peripheral nervous system axon ensheathment (GO:0032292)3.91839844
11myelination in peripheral nervous system (GO:0022011)3.91839844
12neuronal action potential propagation (GO:0019227)3.67581879
13negative regulation of neurotransmitter transport (GO:0051589)3.62618668
14fatty acid elongation (GO:0030497)3.60140638
15cerebral cortex radially oriented cell migration (GO:0021799)3.53195529
16dendritic spine morphogenesis (GO:0060997)3.52847073
17amino acid import (GO:0043090)3.50393009
18pyrimidine nucleobase catabolic process (GO:0006208)3.48621193
19photoreceptor cell differentiation (GO:0046530)3.47951026
20eye photoreceptor cell differentiation (GO:0001754)3.47951026
21astrocyte development (GO:0014002)3.40740929
22regulation of somitogenesis (GO:0014807)3.35477603
23axonal fasciculation (GO:0007413)3.31820296
24astrocyte differentiation (GO:0048708)3.26204363
25negative regulation of neurotransmitter secretion (GO:0046929)3.25795344
26positive regulation of oligodendrocyte differentiation (GO:0048714)3.21751733
27apical protein localization (GO:0045176)3.21606388
28synaptic vesicle maturation (GO:0016188)3.20110679
29otic vesicle formation (GO:0030916)3.15296603
30glomerular filtration (GO:0003094)3.13543489
31asymmetric protein localization (GO:0008105)3.11449982
32lateral sprouting from an epithelium (GO:0060601)3.10536459
33limb bud formation (GO:0060174)3.09684215
34response to methylmercury (GO:0051597)3.06551471
35oligodendrocyte differentiation (GO:0048709)3.06287911
36neuron recognition (GO:0008038)3.05652019
37glycine transport (GO:0015816)3.03950761
38locomotory exploration behavior (GO:0035641)3.00167673
39dendrite morphogenesis (GO:0048813)2.98757036
40negative regulation of axon guidance (GO:1902668)2.98630639
41presynaptic membrane organization (GO:0097090)2.98451142
42negative regulation of axon extension (GO:0030517)2.98039016
43establishment of mitochondrion localization (GO:0051654)2.97854993
44cerebellar granule cell differentiation (GO:0021707)2.95786754
45negative regulation of axonogenesis (GO:0050771)2.95330165
46layer formation in cerebral cortex (GO:0021819)2.94467924
47cellular potassium ion homeostasis (GO:0030007)2.93659761
48neuron cell-cell adhesion (GO:0007158)2.92555292
49cellular response to cholesterol (GO:0071397)2.92272173
50neuroblast proliferation (GO:0007405)2.90341912
51dorsal/ventral axis specification (GO:0009950)2.87456585
52startle response (GO:0001964)2.87390428
53nonmotile primary cilium assembly (GO:0035058)2.87389822
54postsynaptic membrane organization (GO:0001941)2.86846837
55C4-dicarboxylate transport (GO:0015740)2.86728297
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85674220
57nerve growth factor signaling pathway (GO:0038180)2.85161711
58long-chain fatty acid biosynthetic process (GO:0042759)2.83388542
59lung epithelium development (GO:0060428)2.82847376
60paraxial mesoderm development (GO:0048339)2.81926573
61neurotransmitter-gated ion channel clustering (GO:0072578)2.81370485
62protein localization to synapse (GO:0035418)2.80077197
63neuronal ion channel clustering (GO:0045161)2.78674570
64potassium ion import (GO:0010107)2.77830714
65calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76249716
66peptidyl-tyrosine autophosphorylation (GO:0038083)2.75603563
67neuronal stem cell maintenance (GO:0097150)2.75314725
68response to auditory stimulus (GO:0010996)2.74725152
69mechanosensory behavior (GO:0007638)2.73993927
70adult walking behavior (GO:0007628)2.73139227
71renal filtration (GO:0097205)2.72985577
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72742970
73neuromuscular synaptic transmission (GO:0007274)2.71812454
74regulation of astrocyte differentiation (GO:0048710)2.70921910
75axon extension involved in axon guidance (GO:0048846)2.70152719
76neuron projection extension involved in neuron projection guidance (GO:1902284)2.70152719
77sodium ion export (GO:0071436)2.70149558
78central nervous system projection neuron axonogenesis (GO:0021952)2.69902968
79negative regulation of axon extension involved in axon guidance (GO:0048843)2.69519928
80cell communication by electrical coupling (GO:0010644)2.68418390
81neurotransmitter uptake (GO:0001504)2.67725212
82retinal ganglion cell axon guidance (GO:0031290)2.67364951
83retinal rod cell development (GO:0046548)2.64894894
84regulation of oligodendrocyte differentiation (GO:0048713)2.64712587
85gamma-aminobutyric acid transport (GO:0015812)2.64612818
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.62494338
87vocalization behavior (GO:0071625)2.62430889
88notochord development (GO:0030903)2.61544677
89nucleobase catabolic process (GO:0046113)2.61176301
90presynaptic membrane assembly (GO:0097105)2.61138933
91positive regulation of astrocyte differentiation (GO:0048711)2.60408521
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.60026681
93camera-type eye morphogenesis (GO:0048593)2.57747764
94membrane assembly (GO:0071709)2.57396592
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57079111
96neuromuscular junction development (GO:0007528)2.56657051
97positive regulation of glial cell differentiation (GO:0045687)2.56482917
98neuron fate determination (GO:0048664)2.56391118
99organ growth (GO:0035265)2.56212190
100acidic amino acid transport (GO:0015800)2.55733151
101synaptic transmission, glutamatergic (GO:0035249)2.55725849
102regulation of collateral sprouting (GO:0048670)2.55134437
103positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55101644
104regulation of synaptic vesicle exocytosis (GO:2000300)2.55092965
105innervation (GO:0060384)2.54408203
106substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.54314736
107substrate-independent telencephalic tangential migration (GO:0021826)2.54314736
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52101970
109regulation of axon guidance (GO:1902667)2.51217495
110regulation of cardiac muscle cell contraction (GO:0086004)2.50835787
111regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50487614
112auditory behavior (GO:0031223)2.48904604
113negative regulation of oligodendrocyte differentiation (GO:0048715)2.48643390
114G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.48367746
115transmission of nerve impulse (GO:0019226)2.46387274
116lung-associated mesenchyme development (GO:0060484)2.46329553
117glial cell differentiation (GO:0010001)2.46239448
118L-glutamate transport (GO:0015813)2.45550296
119synapse organization (GO:0050808)2.45512050
120glutamate receptor signaling pathway (GO:0007215)2.45399014
121import into cell (GO:0098657)2.45297710
122synapse assembly (GO:0007416)2.45200223
123long-term memory (GO:0007616)2.45153862
124positive regulation of synapse assembly (GO:0051965)2.44975084
125lens fiber cell development (GO:0070307)2.44775990
126negative regulation of astrocyte differentiation (GO:0048712)2.44625953
127myotube differentiation (GO:0014902)2.44567053
128potassium ion homeostasis (GO:0055075)2.44427754
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.43937241
130positive regulation of neuroblast proliferation (GO:0002052)2.43746684
131positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42762578
132regulation of neuronal synaptic plasticity (GO:0048168)2.42524449
133outer ear morphogenesis (GO:0042473)2.42381621
134cellular response to sterol (GO:0036315)2.42291365
135generation of neurons (GO:0048699)2.41878275
136regulation of synapse assembly (GO:0051963)2.40720768
137cranial nerve development (GO:0021545)2.40529750
138cerebral cortex cell migration (GO:0021795)2.38816176
139regulation of short-term neuronal synaptic plasticity (GO:0048172)2.36864936
140cellular sodium ion homeostasis (GO:0006883)2.34377630
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.32039025
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.31275157
143radial glial cell differentiation (GO:0060019)2.30021476
144spinal cord development (GO:0021510)2.29973844
145negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28242491
146regulation of translation, ncRNA-mediated (GO:0045974)2.28242491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.33992137
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04956222
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.88044301
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73046409
5GBX2_23144817_ChIP-Seq_PC3_Human2.71630646
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62651110
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60786920
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60786920
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.47731922
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43083031
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.42795879
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42614742
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35605392
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35054120
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29867825
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.23868507
17AR_21572438_ChIP-Seq_LNCaP_Human2.17246708
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13434279
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.13076421
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12843313
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10332437
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08945988
23DROSHA_22980978_ChIP-Seq_HELA_Human2.02811331
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90826676
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.86455015
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.85555510
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79001084
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77691483
29IGF1R_20145208_ChIP-Seq_DFB_Human1.76603784
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73797908
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72528017
32* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66201716
33TP53_16413492_ChIP-PET_HCT116_Human1.60913724
34FUS_26573619_Chip-Seq_HEK293_Human1.60306886
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59840921
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58391120
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57369629
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56272927
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55371703
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52765463
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.52285638
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48801812
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46113430
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.45974405
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.43190544
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41989218
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41989218
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41817226
49EWS_26573619_Chip-Seq_HEK293_Human1.41693355
50REST_21632747_ChIP-Seq_MESCs_Mouse1.39671797
51* PIAS1_25552417_ChIP-Seq_VCAP_Human1.39453952
52TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38325466
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38222334
54TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37360164
55RNF2_27304074_Chip-Seq_NSC_Mouse1.37110985
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.36198059
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35582514
58* SOX9_26525672_Chip-Seq_HEART_Mouse1.33481790
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.31301581
60TAF15_26573619_Chip-Seq_HEK293_Human1.31170899
61POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.30718466
62* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30215555
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29875764
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28520781
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28132918
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.28071423
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27091349
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.26332421
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25727984
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24545695
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23309943
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22648451
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.22620082
74* P300_19829295_ChIP-Seq_ESCs_Human1.22171021
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21747704
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21443847
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20917299
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20100523
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.19526335
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.18405946
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18204483
82* SMAD4_21799915_ChIP-Seq_A2780_Human1.18023675
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17977896
84TP53_18474530_ChIP-ChIP_U2OS_Human1.17618341
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17150318
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.15383698
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14879538
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.14389637
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14168461
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14168461
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13937791
92AHR_22903824_ChIP-Seq_MCF-7_Human1.13386623
93* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12892806
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12766019
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12098390
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.11997955
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11401514
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10073833
99STAT3_23295773_ChIP-Seq_U87_Human1.09944165
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09826375
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09686592
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09182760
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08383736
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.08244411
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.07827252
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07733585
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.06544988
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05827139
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05684251
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05003875
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04046662
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03766897
113AR_19668381_ChIP-Seq_PC3_Human1.03727478
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01008307
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00558744
116* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98991827
117AR_25329375_ChIP-Seq_VCAP_Human0.98864458
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.98554440
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97966246
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96476274
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95693471
122ZNF274_21170338_ChIP-Seq_K562_Hela0.95365140
123ER_23166858_ChIP-Seq_MCF-7_Human0.94942463
124KDM2B_26808549_Chip-Seq_K562_Human0.94284304
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91785206
126RXR_22108803_ChIP-Seq_LS180_Human0.90338348
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89781606
128TCF4_23295773_ChIP-Seq_U87_Human0.89520933
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88182493
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.86645714
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86634844
132* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86191725
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.85729398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.50513272
2MP0004859_abnormal_synaptic_plasticity3.16314947
3MP0000920_abnormal_myelination3.03865053
4MP0003950_abnormal_plasma_membrane2.74011799
5MP0003880_abnormal_central_pattern2.56014968
6MP0005423_abnormal_somatic_nervous2.41159216
7MP0004885_abnormal_endolymph2.38989634
8MP0003122_maternal_imprinting2.36024677
9MP0006292_abnormal_olfactory_placode2.31330911
10MP0003635_abnormal_synaptic_transmissio2.27185385
11MP0000778_abnormal_nervous_system2.25066076
12MP0001486_abnormal_startle_reflex2.24231607
13MP0005248_abnormal_Harderian_gland2.15507104
14MP0002734_abnormal_mechanical_nocicepti2.13913809
15MP0003690_abnormal_glial_cell2.10539064
16MP0002064_seizures2.06717921
17MP0003329_amyloid_beta_deposits2.04687554
18MP0001299_abnormal_eye_distance/2.03779964
19MP0005171_absent_coat_pigmentation2.01683242
20MP0003634_abnormal_glial_cell1.97459542
21MP0002272_abnormal_nervous_system1.96014782
22MP0009046_muscle_twitch1.95872448
23MP0005623_abnormal_meninges_morphology1.93327516
24MP0001529_abnormal_vocalization1.93300745
25MP0003283_abnormal_digestive_organ1.83538823
26MP0009745_abnormal_behavioral_response1.78197796
27MP0004742_abnormal_vestibular_system1.77256547
28MP0000566_synostosis1.74246331
29MP0000751_myopathy1.73731756
30MP0009780_abnormal_chondrocyte_physiolo1.72339161
31MP0001968_abnormal_touch/_nociception1.70286663
32MP0002063_abnormal_learning/memory/cond1.69664845
33MP0008569_lethality_at_weaning1.66771361
34MP0000955_abnormal_spinal_cord1.66513330
35MP0001984_abnormal_olfaction1.65130340
36MP0000733_abnormal_muscle_development1.63552202
37MP0008438_abnormal_cutaneous_collagen1.60540538
38MP0000579_abnormal_nail_morphology1.59963980
39MP0001485_abnormal_pinna_reflex1.56253176
40MP0002572_abnormal_emotion/affect_behav1.54922912
41MP0000569_abnormal_digit_pigmentation1.54836222
42MP0004858_abnormal_nervous_system1.52588213
43MP0001293_anophthalmia1.51599027
44MP0003632_abnormal_nervous_system1.49820474
45MP0003136_yellow_coat_color1.49818720
46MP0004145_abnormal_muscle_electrophysio1.48232982
47MP0002638_abnormal_pupillary_reflex1.48205826
48MP0002736_abnormal_nociception_after1.48000080
49MP0002067_abnormal_sensory_capabilities1.47597931
50MP0003121_genomic_imprinting1.42585721
51MP0010678_abnormal_skin_adnexa1.41173208
52MP0002882_abnormal_neuron_morphology1.40843167
53MP0000747_muscle_weakness1.40666545
54MP0004142_abnormal_muscle_tone1.38509783
55MP0003633_abnormal_nervous_system1.38262868
56MP0003631_nervous_system_phenotype1.37769689
57MP0000049_abnormal_middle_ear1.35043998
58MP0010030_abnormal_orbit_morphology1.34863338
59MP0000749_muscle_degeneration1.33697732
60MP0000383_abnormal_hair_follicle1.33442948
61MP0003787_abnormal_imprinting1.32343801
62MP0002184_abnormal_innervation1.31534795
63MP0008877_abnormal_DNA_methylation1.30619983
64MP0008789_abnormal_olfactory_epithelium1.29039206
65MP0003878_abnormal_ear_physiology1.26703233
66MP0005377_hearing/vestibular/ear_phenot1.26703233
67MP0002234_abnormal_pharynx_morphology1.26428909
68MP0006072_abnormal_retinal_apoptosis1.25990657
69MP0001177_atelectasis1.21971155
70MP0001440_abnormal_grooming_behavior1.19092862
71MP0002066_abnormal_motor_capabilities/c1.18123603
72MP0001970_abnormal_pain_threshold1.17325156
73MP0005394_taste/olfaction_phenotype1.16442828
74MP0005499_abnormal_olfactory_system1.16442828
75MP0005253_abnormal_eye_physiology1.16097326
76MP0002108_abnormal_muscle_morphology1.14517066
77MP0009250_abnormal_appendicular_skeleto1.14494856
78MP0003938_abnormal_ear_development1.11242060
79MP0003119_abnormal_digestive_system1.10910148
80MP0000647_abnormal_sebaceous_gland1.10324051
81MP0006276_abnormal_autonomic_nervous1.09317029
82MP0002152_abnormal_brain_morphology1.08617976
83MP0005187_abnormal_penis_morphology1.08211851
84MP0004272_abnormal_basement_membrane1.07853709
85MP0002557_abnormal_social/conspecific_i1.05931915
86MP0002653_abnormal_ependyma_morphology1.04984825
87MP0001346_abnormal_lacrimal_gland1.04943321
88MP0002938_white_spotting1.04573928
89MP0005503_abnormal_tendon_morphology1.04490939
90MP0002697_abnormal_eye_size1.04449039
91MP0009384_cardiac_valve_regurgitation1.03679755
92MP0002752_abnormal_somatic_nervous1.02617510
93MP0000537_abnormal_urethra_morphology1.00644955
94MP0004134_abnormal_chest_morphology0.99713234
95MP0005257_abnormal_intraocular_pressure0.99501030
96MP0002229_neurodegeneration0.99241399
97MP0004811_abnormal_neuron_physiology0.98344591
98MP0003137_abnormal_impulse_conducting0.98060712
99MP0004924_abnormal_behavior0.97687058
100MP0005386_behavior/neurological_phenoty0.97687058
101MP0002733_abnormal_thermal_nociception0.97164793
102MP0000428_abnormal_craniofacial_morphol0.96079465
103MP0005646_abnormal_pituitary_gland0.95719214
104MP0000026_abnormal_inner_ear0.94861999
105MP0001502_abnormal_circadian_rhythm0.93662764
106MP0004133_heterotaxia0.92755481
107MP0002751_abnormal_autonomic_nervous0.92511113
108MP0003755_abnormal_palate_morphology0.92396755
109MP0002735_abnormal_chemical_nociception0.92284047
110MP0005391_vision/eye_phenotype0.91718018
111MP0003942_abnormal_urinary_system0.91616567
112MP0000534_abnormal_ureter_morphology0.89780111
113MP0001905_abnormal_dopamine_level0.89620514
114MP0002822_catalepsy0.89189596
115MP0003861_abnormal_nervous_system0.88946404
116MP0005551_abnormal_eye_electrophysiolog0.87883667
117MP0000750_abnormal_muscle_regeneration0.87853857
118MP0005409_darkened_coat_color0.87201464
119MP0002116_abnormal_craniofacial_bone0.86534502
120MP0002932_abnormal_joint_morphology0.86389291
121MP0001286_abnormal_eye_development0.86116647
122MP0002233_abnormal_nose_morphology0.85006158
123MP0002249_abnormal_larynx_morphology0.84758979
124MP0003385_abnormal_body_wall0.84700868
125MP0000462_abnormal_digestive_system0.84419247
126MP0003937_abnormal_limbs/digits/tail_de0.84068753
127MP0003935_abnormal_craniofacial_develop0.84059685
128MP0000631_abnormal_neuroendocrine_gland0.83115943
129MP0001963_abnormal_hearing_physiology0.83111652
130MP0003567_abnormal_fetal_cardiomyocyte0.82788655
131MP0001943_abnormal_respiration0.81727706
132MP0002090_abnormal_vision0.81111429
133MP0004233_abnormal_muscle_weight0.80776136

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.16916142
2Aplasia involving bones of the extremities (HP:0009825)3.84673204
3Aplasia involving bones of the upper limbs (HP:0009823)3.84673204
4Aplasia of the phalanges of the hand (HP:0009802)3.84673204
5Action tremor (HP:0002345)3.58632435
6Hepatoblastoma (HP:0002884)3.48277352
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.40803015
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.40803015
9Abnormal auditory evoked potentials (HP:0006958)3.39835974
10Peripheral hypomyelination (HP:0007182)3.20189663
11Termporal pattern (HP:0011008)3.19868267
12Insidious onset (HP:0003587)3.19868267
13Cerebral inclusion bodies (HP:0100314)3.17834534
14Myokymia (HP:0002411)3.08800399
15Megalencephaly (HP:0001355)3.04441646
16Exercise-induced muscle cramps (HP:0003710)3.04144629
17Onion bulb formation (HP:0003383)3.03429481
18Fetal akinesia sequence (HP:0001989)3.01708171
19Colon cancer (HP:0003003)2.99186832
20Alacrima (HP:0000522)2.94915176
21Pterygium (HP:0001059)2.93382421
22Septo-optic dysplasia (HP:0100842)2.92718002
23Gowers sign (HP:0003391)2.92696621
24Abnormality of the corticospinal tract (HP:0002492)2.84981052
25Ankle clonus (HP:0011448)2.81489930
26Supranuclear gaze palsy (HP:0000605)2.80066437
27Coronal craniosynostosis (HP:0004440)2.79115656
28Akinesia (HP:0002304)2.78430439
29Round ear (HP:0100830)2.71282302
30Abnormality of the labia minora (HP:0012880)2.70016694
31Scanning speech (HP:0002168)2.68357801
32Vitreoretinal degeneration (HP:0000655)2.53723330
33Focal motor seizures (HP:0011153)2.52305963
34Cutaneous finger syndactyly (HP:0010554)2.52143771
35Cutaneous syndactyly (HP:0012725)2.51757229
36Intention tremor (HP:0002080)2.48027158
37Decreased lacrimation (HP:0000633)2.44021782
38Calcaneovalgus deformity (HP:0001848)2.43891479
39Spastic gait (HP:0002064)2.40893366
40Aplasia of the musculature (HP:0100854)2.40790340
41Infantile muscular hypotonia (HP:0008947)2.40138873
42Dysmetria (HP:0001310)2.38325874
43Muscle fiber splitting (HP:0003555)2.37905902
44Neonatal short-limb short stature (HP:0008921)2.37685751
45Focal seizures (HP:0007359)2.37180532
46Premature rupture of membranes (HP:0001788)2.35142659
47Shallow orbits (HP:0000586)2.33185244
48Abnormality of the ischium (HP:0003174)2.33118807
49Lower limb amyotrophy (HP:0007210)2.27894017
50Segmental peripheral demyelination/remyelination (HP:0003481)2.24007572
51Hammertoe (HP:0001765)2.22192988
52Popliteal pterygium (HP:0009756)2.21309155
53Absent septum pellucidum (HP:0001331)2.19677469
54Short 4th metacarpal (HP:0010044)2.17460779
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17460779
56Broad metatarsal (HP:0001783)2.15779232
57Anteriorly placed anus (HP:0001545)2.10034092
58Retinal dysplasia (HP:0007973)2.09696701
59Epileptic encephalopathy (HP:0200134)2.09369695
60Clumsiness (HP:0002312)2.08967775
61Optic nerve hypoplasia (HP:0000609)2.08109413
62Aqueductal stenosis (HP:0002410)2.07517376
63Deformed tarsal bones (HP:0008119)2.07343710
64Bell-shaped thorax (HP:0001591)2.06632487
65Chin dimple (HP:0010751)2.04293652
66Abnormality of the calf musculature (HP:0001430)2.02329282
67Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.01981772
68Abnormality of the middle phalanges of the toes (HP:0010183)2.01338024
69Thin ribs (HP:0000883)2.00257078
70Amniotic constriction ring (HP:0009775)1.99959549
71Abnormality of placental membranes (HP:0011409)1.99959549
72Split foot (HP:0001839)1.99811135
73Hemiplegia (HP:0002301)1.99513996
74Hypoplastic heart (HP:0001961)1.99513152
75Lower limb muscle weakness (HP:0007340)1.99024233
76Bronchomalacia (HP:0002780)1.95928233
77Aplasia/Hypoplasia of the sternum (HP:0006714)1.94441673
78Progressive cerebellar ataxia (HP:0002073)1.94329860
79Dysdiadochokinesis (HP:0002075)1.92392931
80Preaxial foot polydactyly (HP:0001841)1.91423871
81Thickened helices (HP:0000391)1.91360756
82Medulloblastoma (HP:0002885)1.91020602
83Scapular winging (HP:0003691)1.90319813
84Partial duplication of thumb phalanx (HP:0009944)1.88684266
85Generalized tonic-clonic seizures (HP:0002069)1.88561754
86Long clavicles (HP:0000890)1.85015831
87Hemiparesis (HP:0001269)1.84891610
88Drooling (HP:0002307)1.84529467
89Distal lower limb amyotrophy (HP:0008944)1.84484272
90Atonic seizures (HP:0010819)1.83681971
91Hypoplasia of the iris (HP:0007676)1.82825459
92Postural tremor (HP:0002174)1.82002909
93Urinary urgency (HP:0000012)1.81269772
94Febrile seizures (HP:0002373)1.80642140
95Foot dorsiflexor weakness (HP:0009027)1.80642021
96Abnormality of the septum pellucidum (HP:0007375)1.80406672
97Absent phalangeal crease (HP:0006109)1.80020496
98Abnormality of the 4th metacarpal (HP:0010012)1.79778451
99Choanal stenosis (HP:0000452)1.79719578
100Muscle fiber inclusion bodies (HP:0100299)1.79500361
101Glioma (HP:0009733)1.77107331
102Turricephaly (HP:0000262)1.77093914
103Hypoplastic ischia (HP:0003175)1.76376028
104Renal hypoplasia (HP:0000089)1.76348444
105Weak cry (HP:0001612)1.76254177
106Synostosis involving the elbow (HP:0003938)1.75561961
107Humeroradial synostosis (HP:0003041)1.75561961
108Oligodactyly (HP:0012165)1.75346791
109Hypoplastic pelvis (HP:0008839)1.74936282
110Trigonocephaly (HP:0000243)1.74778828
111True hermaphroditism (HP:0010459)1.73888338
112Mixed hearing impairment (HP:0000410)1.73877767
113Nemaline bodies (HP:0003798)1.73710950
114Distal arthrogryposis (HP:0005684)1.73676241
115Partial duplication of the phalanx of hand (HP:0009999)1.72552051
116Broad foot (HP:0001769)1.72443479
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71536682
118Buphthalmos (HP:0000557)1.71506134
119Astrocytoma (HP:0009592)1.71491758
120Abnormality of the astrocytes (HP:0100707)1.71491758
121Genital tract atresia (HP:0001827)1.71415362
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71263560
123Abnormality of the foot musculature (HP:0001436)1.71104947
124Decreased motor nerve conduction velocity (HP:0003431)1.70878954
125Morphological abnormality of the middle ear (HP:0008609)1.70259513
126Vaginal atresia (HP:0000148)1.70114780
127Abnormality of the diencephalon (HP:0010662)1.69864428
128Pheochromocytoma (HP:0002666)1.69716700
129Increased variability in muscle fiber diameter (HP:0003557)1.69363161
130Broad-based gait (HP:0002136)1.68911839
131Hyperventilation (HP:0002883)1.68639111
132Intestinal atresia (HP:0011100)1.67884921
133Oligodactyly (hands) (HP:0001180)1.66935580
134Malignant hyperthermia (HP:0002047)1.66893386
135Abnormality of the neuromuscular junction (HP:0003398)1.66575326
136Fatigable weakness (HP:0003473)1.66575326
137Abnormality of the antihelix (HP:0009738)1.66306948
138Fibular hypoplasia (HP:0003038)1.65235410
139Neoplasm of the oral cavity (HP:0100649)1.64774933
140Short hallux (HP:0010109)1.64201246
141Gait imbalance (HP:0002141)1.64192261
142* Difficulty running (HP:0009046)1.63632688
143Muscle hypertrophy of the lower extremities (HP:0008968)1.63457651
144Aplasia/Hypoplasia of the fibula (HP:0006492)1.63004642
145Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62260258
146Limited hip movement (HP:0008800)1.61476705
147Rocker bottom foot (HP:0001838)1.61440207
148Abnormal finger flexion creases (HP:0006143)1.60398479
149Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60250905
150Abnormality of the lower motor neuron (HP:0002366)1.59658873
151Mildly elevated creatine phosphokinase (HP:0008180)1.59465296
152Rib fusion (HP:0000902)1.59137189
153Excessive salivation (HP:0003781)1.58705761
154Truncal ataxia (HP:0002078)1.58538521
155Tarsal synostosis (HP:0008368)1.58503697
156Esophageal atresia (HP:0002032)1.58478649
157Specific learning disability (HP:0001328)1.57632452
158Arterial tortuosity (HP:0005116)1.57455009
159Breech presentation (HP:0001623)1.56751777
160Hyporeflexia of lower limbs (HP:0002600)1.55980319
161Supernumerary spleens (HP:0009799)1.53665971
162Omphalocele (HP:0001539)1.51217953
163Tracheomalacia (HP:0002779)1.50672850
164Papillary thyroid carcinoma (HP:0002895)1.50264462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.39405450
2MUSK3.21922204
3FGFR22.91752589
4OXSR12.61615103
5EPHB12.56260514
6NTRK22.53106513
7NTRK12.40792825
8MOS2.34274860
9MKNK22.24924534
10TYRO32.16126935
11MAPKAPK51.98652027
12EPHA41.93236691
13PAK61.91467215
14MKNK11.87143707
15ROCK21.81767648
16WNK31.81413031
17MARK11.76692235
18KSR11.74168544
19PKN11.73498927
20BCR1.72070426
21DDR21.69019997
22PRKD31.67315299
23OBSCN1.64866512
24NTRK31.54564900
25WEE11.51094124
26EPHB21.51022007
27WNK11.50060938
28CDK181.47749293
29CDK151.47146045
30CDK191.45774362
31SGK4941.45044148
32SGK2231.45044148
33UHMK11.43557026
34MET1.39680656
35CDK141.39066132
36PHKG21.39007663
37PHKG11.39007663
38PNCK1.35077261
39TNIK1.30637862
40CDK11A1.30311561
41LIMK11.29161305
42NEK61.28608536
43CDK51.20980136
44PAK31.18332664
45CASK1.15254827
46CAMK2B1.14527836
47DMPK1.11276446
48PDGFRA1.09912228
49MAP3K91.07722633
50KSR21.07581714
51MINK11.06849573
52BRD41.05960439
53PINK11.04036987
54SIK11.03636678
55LATS21.03570444
56BMX1.01527973
57CAMK2D1.00411528
58MARK20.98740843
59TSSK60.96889432
60CDC70.95681764
61CCNB10.94950723
62EPHA30.94504573
63LATS10.93186423
64PRKCG0.93002012
65SGK20.92539416
66BMPR1B0.91195579
67FGR0.89950678
68MAPK150.89381577
69ERBB20.88946216
70CSNK1A1L0.88846948
71MAP3K40.88100074
72TRIB30.87920911
73CSNK1G20.87517162
74PRPF4B0.86889138
75CAMK1G0.86018131
76MAPK130.85456169
77CAMK2A0.85076798
78ICK0.83036226
79RET0.81875396
80DAPK20.78625925
81PBK0.78537403
82CAMK2G0.77554250
83PRKCE0.75476410
84PRKD10.75464598
85MAP2K70.74893092
86STK38L0.73983683
87MAP3K100.73936371
88PLK30.72176551
89CSNK1G30.71778289
90ROCK10.71254633
91WNK40.70774090
92FGFR10.70200532
93IRAK20.69717751
94CAMKK10.68992371
95PLK20.68982665
96DYRK30.67407527
97PDGFRB0.66368987
98SRPK10.65767727
99PRKCH0.64377406
100BRSK10.63132107
101TIE10.62058429
102TTK0.61990701
103STK110.59224781
104FYN0.57947905
105CAMK10.57048456
106CDK30.56058094
107YES10.53025442
108CSNK1G10.52807755
109RPS6KA40.51722265
110ERBB40.51082542
111PTK20.51027727
112NUAK10.50532796
113PAK20.49702478
114CDC42BPA0.49602313
115PRKACB0.47776047
116MAP4K20.47480079
117BRSK20.47252514
118PRKD20.47104956
119MAPK100.47039763
120ERBB30.47022746
121NEK10.46813298
122CSNK1A10.46622491
123PRKG10.46335442
124PDPK10.45172744
125DYRK20.45109882
126SGK10.44276214
127PTK2B0.44225128
128DYRK1A0.43760739
129HIPK20.43647061
130TTN0.43609918
131MAP2K10.43453731
132PRKDC0.42827225
133SGK30.42625801
134ILK0.42400412
135RIPK10.42255169
136* SRC0.41999828
137CSNK1D0.40817837
138RPS6KA30.40148657
139CAMK40.39295653

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.12055203
2Steroid biosynthesis_Homo sapiens_hsa001002.16322247
3Axon guidance_Homo sapiens_hsa043602.15153127
4Glutamatergic synapse_Homo sapiens_hsa047242.12979983
5GABAergic synapse_Homo sapiens_hsa047272.07878177
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05822373
7Dorso-ventral axis formation_Homo sapiens_hsa043202.01503712
8Circadian entrainment_Homo sapiens_hsa047131.91608142
9Nicotine addiction_Homo sapiens_hsa050331.76143467
10Fatty acid elongation_Homo sapiens_hsa000621.73186287
11Morphine addiction_Homo sapiens_hsa050321.71410330
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68519861
13Long-term depression_Homo sapiens_hsa047301.60908935
14Salivary secretion_Homo sapiens_hsa049701.58948204
15Propanoate metabolism_Homo sapiens_hsa006401.56370996
16Cocaine addiction_Homo sapiens_hsa050301.55745436
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53945490
18Gastric acid secretion_Homo sapiens_hsa049711.52949926
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42933094
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39386507
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37204495
22Hedgehog signaling pathway_Homo sapiens_hsa043401.37110187
23Dopaminergic synapse_Homo sapiens_hsa047281.36919124
24Ether lipid metabolism_Homo sapiens_hsa005651.36307801
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34883484
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33088223
27Cholinergic synapse_Homo sapiens_hsa047251.32856999
28Dilated cardiomyopathy_Homo sapiens_hsa054141.31799424
29Gap junction_Homo sapiens_hsa045401.31749865
30Long-term potentiation_Homo sapiens_hsa047201.31099138
31Basal cell carcinoma_Homo sapiens_hsa052171.29129442
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28084491
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28048678
34Serotonergic synapse_Homo sapiens_hsa047261.28029177
35Adherens junction_Homo sapiens_hsa045201.25844973
36Amphetamine addiction_Homo sapiens_hsa050311.24207436
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23474297
38Melanogenesis_Homo sapiens_hsa049161.21974199
39Renal cell carcinoma_Homo sapiens_hsa052111.21672359
40Olfactory transduction_Homo sapiens_hsa047401.21421252
41Circadian rhythm_Homo sapiens_hsa047101.20468653
42Insulin secretion_Homo sapiens_hsa049111.20298761
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18882862
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17057325
45ErbB signaling pathway_Homo sapiens_hsa040121.13109208
46Vitamin B6 metabolism_Homo sapiens_hsa007501.12737143
47Synaptic vesicle cycle_Homo sapiens_hsa047211.11751739
48ECM-receptor interaction_Homo sapiens_hsa045121.10098805
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09570593
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07791099
51Renin secretion_Homo sapiens_hsa049241.07784281
52Phototransduction_Homo sapiens_hsa047441.06173376
53Protein digestion and absorption_Homo sapiens_hsa049741.05873024
54Fatty acid biosynthesis_Homo sapiens_hsa000611.05818210
55Arginine and proline metabolism_Homo sapiens_hsa003301.05371335
56Glioma_Homo sapiens_hsa052141.03764982
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02397144
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.01886088
59Oxytocin signaling pathway_Homo sapiens_hsa049211.01609038
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01340336
61Tight junction_Homo sapiens_hsa045301.01192101
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97547089
63beta-Alanine metabolism_Homo sapiens_hsa004100.97453835
64Notch signaling pathway_Homo sapiens_hsa043300.96723697
65Hippo signaling pathway_Homo sapiens_hsa043900.96425829
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94922012
67GnRH signaling pathway_Homo sapiens_hsa049120.93749345
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92600180
69cAMP signaling pathway_Homo sapiens_hsa040240.92518333
70Taste transduction_Homo sapiens_hsa047420.92356228
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.92031608
72Estrogen signaling pathway_Homo sapiens_hsa049150.91698590
73Wnt signaling pathway_Homo sapiens_hsa043100.91160469
74Calcium signaling pathway_Homo sapiens_hsa040200.90810895
75Oocyte meiosis_Homo sapiens_hsa041140.90543989
76Lysine degradation_Homo sapiens_hsa003100.88656949
77Focal adhesion_Homo sapiens_hsa045100.86999124
78Proteoglycans in cancer_Homo sapiens_hsa052050.84264722
79Butanoate metabolism_Homo sapiens_hsa006500.83916656
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83467756
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.83046555
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.82699368
83Ras signaling pathway_Homo sapiens_hsa040140.81096188
84Choline metabolism in cancer_Homo sapiens_hsa052310.78720710
85Pancreatic secretion_Homo sapiens_hsa049720.77438883
86Biosynthesis of amino acids_Homo sapiens_hsa012300.76046733
87TGF-beta signaling pathway_Homo sapiens_hsa043500.75320425
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75258252
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74696269
90Histidine metabolism_Homo sapiens_hsa003400.74595240
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73017246
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72644890
93Prion diseases_Homo sapiens_hsa050200.72075925
94Rap1 signaling pathway_Homo sapiens_hsa040150.71539284
95Sphingolipid metabolism_Homo sapiens_hsa006000.71415795
96Endocytosis_Homo sapiens_hsa041440.66313236
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64567946
98Thyroid hormone synthesis_Homo sapiens_hsa049180.64369704
99MAPK signaling pathway_Homo sapiens_hsa040100.64258766
100Colorectal cancer_Homo sapiens_hsa052100.62202632
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61672143
102Cardiac muscle contraction_Homo sapiens_hsa042600.61470579
103Fatty acid metabolism_Homo sapiens_hsa012120.60267405
104Sulfur metabolism_Homo sapiens_hsa009200.58519911
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57291102
106Ovarian steroidogenesis_Homo sapiens_hsa049130.56543041
107Endometrial cancer_Homo sapiens_hsa052130.56369688
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55161383
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55081281
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54743376
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53371248
112mRNA surveillance pathway_Homo sapiens_hsa030150.52993641
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52252839
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52114367
115Glucagon signaling pathway_Homo sapiens_hsa049220.50788486
116Bile secretion_Homo sapiens_hsa049760.49679218
117Pyruvate metabolism_Homo sapiens_hsa006200.49570771
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48617621
119Vibrio cholerae infection_Homo sapiens_hsa051100.48474802
120Inositol phosphate metabolism_Homo sapiens_hsa005620.47759453
121Mineral absorption_Homo sapiens_hsa049780.46829059
122RNA degradation_Homo sapiens_hsa030180.46080461
123Alcoholism_Homo sapiens_hsa050340.45097789
124Carbon metabolism_Homo sapiens_hsa012000.44453848
125MicroRNAs in cancer_Homo sapiens_hsa052060.44382120
126Non-small cell lung cancer_Homo sapiens_hsa052230.43003645
127Melanoma_Homo sapiens_hsa052180.42734576
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41836774
129Cell cycle_Homo sapiens_hsa041100.40470780

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