

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | central nervous system myelination (GO:0022010) | 7.02884726 |
| 2 | axon ensheathment in central nervous system (GO:0032291) | 7.02884726 |
| 3 | neuron cell-cell adhesion (GO:0007158) | 4.97830431 |
| 4 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.92621491 |
| 5 | neuronal action potential propagation (GO:0019227) | 4.83460779 |
| 6 | presynaptic membrane assembly (GO:0097105) | 4.65726015 |
| 7 | presynaptic membrane organization (GO:0097090) | 4.61248355 |
| 8 | long-chain fatty acid biosynthetic process (GO:0042759) | 4.55047151 |
| 9 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.48407091 |
| 10 | exploration behavior (GO:0035640) | 4.47918290 |
| 11 | synaptic vesicle maturation (GO:0016188) | 4.43768197 |
| 12 | L-amino acid import (GO:0043092) | 4.28645651 |
| 13 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.09777343 |
| 14 | cellular potassium ion homeostasis (GO:0030007) | 4.08612407 |
| 15 | myelination (GO:0042552) | 4.06636376 |
| 16 | fatty acid elongation (GO:0030497) | 4.03865764 |
| 17 | ensheathment of neurons (GO:0007272) | 4.00464805 |
| 18 | axon ensheathment (GO:0008366) | 4.00464805 |
| 19 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.94896434 |
| 20 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.94817846 |
| 21 | transmission of nerve impulse (GO:0019226) | 3.91664519 |
| 22 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.89231280 |
| 23 | negative regulation of neurotransmitter transport (GO:0051589) | 3.85182203 |
| 24 | cerebellar granule cell differentiation (GO:0021707) | 3.83902112 |
| 25 | potassium ion import (GO:0010107) | 3.77888984 |
| 26 | vocalization behavior (GO:0071625) | 3.75743038 |
| 27 | glutamate receptor signaling pathway (GO:0007215) | 3.74386101 |
| 28 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.73279480 |
| 29 | regulation of synaptic vesicle transport (GO:1902803) | 3.71642966 |
| 30 | negative regulation of protein localization to cell surface (GO:2000009) | 3.68184926 |
| 31 | neurotransmitter secretion (GO:0007269) | 3.62430882 |
| 32 | adult walking behavior (GO:0007628) | 3.58622589 |
| 33 | neuron recognition (GO:0008038) | 3.57434678 |
| 34 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.57388743 |
| 35 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.56985609 |
| 36 | sodium ion export (GO:0071436) | 3.53459669 |
| 37 | dendritic spine morphogenesis (GO:0060997) | 3.49748162 |
| 38 | amino acid import (GO:0043090) | 3.49275500 |
| 39 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.48804136 |
| 40 | potassium ion homeostasis (GO:0055075) | 3.47933501 |
| 41 | gamma-aminobutyric acid transport (GO:0015812) | 3.43658421 |
| 42 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.41085311 |
| 43 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.40466188 |
| 44 | limb bud formation (GO:0060174) | 3.39398479 |
| 45 | positive regulation of synapse assembly (GO:0051965) | 3.38437086 |
| 46 | postsynaptic membrane organization (GO:0001941) | 3.36133461 |
| 47 | synaptic transmission, glutamatergic (GO:0035249) | 3.34602755 |
| 48 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.33675681 |
| 49 | neuron remodeling (GO:0016322) | 3.31963576 |
| 50 | acidic amino acid transport (GO:0015800) | 3.30777642 |
| 51 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.30295012 |
| 52 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.24011496 |
| 53 | neuron-neuron synaptic transmission (GO:0007270) | 3.23263771 |
| 54 | regulation of neurotransmitter secretion (GO:0046928) | 3.20531583 |
| 55 | positive regulation of action potential (GO:0045760) | 3.19822262 |
| 56 | auditory behavior (GO:0031223) | 3.16556977 |
| 57 | protein localization to synapse (GO:0035418) | 3.15262197 |
| 58 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.14984399 |
| 59 | righting reflex (GO:0060013) | 3.13452812 |
| 60 | regulation of synapse structural plasticity (GO:0051823) | 3.12203019 |
| 61 | locomotory exploration behavior (GO:0035641) | 3.11334716 |
| 62 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.11303882 |
| 63 | mechanosensory behavior (GO:0007638) | 3.09904182 |
| 64 | import into cell (GO:0098657) | 3.08784354 |
| 65 | startle response (GO:0001964) | 3.07689492 |
| 66 | photoreceptor cell differentiation (GO:0046530) | 3.07210165 |
| 67 | eye photoreceptor cell differentiation (GO:0001754) | 3.07210165 |
| 68 | axonal fasciculation (GO:0007413) | 3.06818876 |
| 69 | regulation of neurotransmitter transport (GO:0051588) | 3.06707548 |
| 70 | establishment of mitochondrion localization (GO:0051654) | 3.06038415 |
| 71 | regulation of collateral sprouting (GO:0048670) | 3.02953887 |
| 72 | glycerophospholipid catabolic process (GO:0046475) | 3.02485192 |
| 73 | neuromuscular synaptic transmission (GO:0007274) | 3.01908178 |
| 74 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.01308021 |
| 75 | regulation of axon regeneration (GO:0048679) | 2.99025786 |
| 76 | regulation of neuron projection regeneration (GO:0070570) | 2.99025786 |
| 77 | C4-dicarboxylate transport (GO:0015740) | 2.97904876 |
| 78 | oligodendrocyte differentiation (GO:0048709) | 2.97461035 |
| 79 | membrane depolarization during action potential (GO:0086010) | 2.96152736 |
| 80 | regulation of neurotransmitter levels (GO:0001505) | 2.95168861 |
| 81 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.94856638 |
| 82 | positive regulation of neurotransmitter transport (GO:0051590) | 2.94615049 |
| 83 | neurotransmitter uptake (GO:0001504) | 2.93293579 |
| 84 | L-glutamate transport (GO:0015813) | 2.92687760 |
| 85 | positive regulation of synapse maturation (GO:0090129) | 2.91426610 |
| 86 | neuromuscular process controlling balance (GO:0050885) | 2.90510022 |
| 87 | neuronal ion channel clustering (GO:0045161) | 2.88987159 |
| 88 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 2.88225772 |
| 89 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.86152715 |
| 90 | regulation of dendritic spine development (GO:0060998) | 2.85942390 |
| 91 | synaptic vesicle endocytosis (GO:0048488) | 2.85469242 |
| 92 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.82505312 |
| 93 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.80596641 |
| 94 | response to methylmercury (GO:0051597) | 2.80078695 |
| 95 | positive regulation of dendritic spine development (GO:0060999) | 2.78192720 |
| 96 | synapse organization (GO:0050808) | 2.77671792 |
| 97 | cranial nerve development (GO:0021545) | 2.77172754 |
| 98 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.77143075 |
| 99 | dermatan sulfate biosynthetic process (GO:0030208) | 2.75246501 |
| 100 | synaptic vesicle exocytosis (GO:0016079) | 2.74730165 |
| 101 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.74713558 |
| 102 | synapse assembly (GO:0007416) | 2.73782517 |
| 103 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.72536737 |
| 104 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.71821077 |
| 105 | cell differentiation in hindbrain (GO:0021533) | 2.70530732 |
| 106 | dendrite morphogenesis (GO:0048813) | 2.69030520 |
| 107 | regulation of timing of cell differentiation (GO:0048505) | 2.67986289 |
| 108 | regulation of synapse assembly (GO:0051963) | 2.66273824 |
| 109 | glycine transport (GO:0015816) | 2.65535910 |
| 110 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.64292881 |
| 111 | response to auditory stimulus (GO:0010996) | 2.62870353 |
| 112 | long-term memory (GO:0007616) | 2.62521041 |
| 113 | regulation of postsynaptic membrane potential (GO:0060078) | 2.61719596 |
| 114 | adult locomotory behavior (GO:0008344) | 2.61575175 |
| 115 | negative regulation of synaptic transmission (GO:0050805) | 2.61562422 |
| 116 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.61480931 |
| 117 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.59156022 |
| 118 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.58704410 |
| 119 | regulation of respiratory system process (GO:0044065) | 2.56990748 |
| 120 | positive regulation of membrane potential (GO:0045838) | 2.56746332 |
| 121 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.56599794 |
| 122 | membrane assembly (GO:0071709) | 2.56041821 |
| 123 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.54930963 |
| 124 | membrane depolarization (GO:0051899) | 2.53626752 |
| 125 | membrane hyperpolarization (GO:0060081) | 2.53085892 |
| 126 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.52947184 |
| 127 | regulation of feeding behavior (GO:0060259) | 2.52362941 |
| 128 | regulation of respiratory gaseous exchange (GO:0043576) | 2.51709279 |
| 129 | negative regulation of axon extension (GO:0030517) | 2.50577625 |
| 130 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 2.50027181 |
| 131 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 2.50027181 |
| 132 | glutamate secretion (GO:0014047) | 2.48708823 |
| 133 | cellular response to epinephrine stimulus (GO:0071872) | 2.48569740 |
| 134 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.47602142 |
| 135 | apical protein localization (GO:0045176) | 2.47355926 |
| 136 | mating behavior (GO:0007617) | 2.47273749 |
| 137 | response to epinephrine (GO:0071871) | 2.46669542 |
| 138 | neurotransmitter transport (GO:0006836) | 2.44235824 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.54223081 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.79086754 |
| 3 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.87017708 |
| 4 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.74766051 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.74064969 |
| 6 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.52731313 |
| 7 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.49992991 |
| 8 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.43604990 |
| 9 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.40668525 |
| 10 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.40668525 |
| 11 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.40624012 |
| 12 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.34899023 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.33777539 |
| 14 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.32796800 |
| 15 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.32145139 |
| 16 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.27011927 |
| 17 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.24842653 |
| 18 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.10985602 |
| 19 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.05209207 |
| 20 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.04359298 |
| 21 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.02664263 |
| 22 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.01631600 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.99213702 |
| 24 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.97358907 |
| 25 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.92984334 |
| 26 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.77102966 |
| 27 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.75732065 |
| 28 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.75691041 |
| 29 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.74869523 |
| 30 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 1.74728539 |
| 31 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.74423615 |
| 32 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.74349269 |
| 33 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.73368281 |
| 34 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.73163165 |
| 35 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.72951568 |
| 36 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.72866915 |
| 37 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.64813571 |
| 38 | P300_19829295_ChIP-Seq_ESCs_Human | 1.63641316 |
| 39 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.63162794 |
| 40 | VDR_22108803_ChIP-Seq_LS180_Human | 1.63006675 |
| 41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.62282020 |
| 42 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.60202447 |
| 43 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.56950597 |
| 44 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.55462069 |
| 45 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.55020776 |
| 46 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.52546966 |
| 47 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.52528010 |
| 48 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.51483347 |
| 49 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.51460181 |
| 50 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.50851921 |
| 51 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48736494 |
| 52 | FUS_26573619_Chip-Seq_HEK293_Human | 1.47497501 |
| 53 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.42312977 |
| 54 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.40176130 |
| 55 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.39630986 |
| 56 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.36951160 |
| 57 | * AR_19668381_ChIP-Seq_PC3_Human | 1.36816305 |
| 58 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.35434958 |
| 59 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.35361812 |
| 60 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.32734177 |
| 61 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.32368905 |
| 62 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.32142092 |
| 63 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.30057705 |
| 64 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.28910880 |
| 65 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25160973 |
| 66 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.24601168 |
| 67 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.24485835 |
| 68 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.23605044 |
| 69 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.23541445 |
| 70 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.22739149 |
| 71 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.22078131 |
| 72 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.21966677 |
| 73 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.21142781 |
| 74 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.21118106 |
| 75 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.20659362 |
| 76 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.20124175 |
| 77 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.19611691 |
| 78 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.19409501 |
| 79 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.19401404 |
| 80 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.17644123 |
| 81 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.17053394 |
| 82 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.16945279 |
| 83 | TCF4_23295773_ChIP-Seq_U87_Human | 1.16384881 |
| 84 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15892895 |
| 85 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.15892895 |
| 86 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.15299564 |
| 87 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.14923222 |
| 88 | KDM2B_26808549_Chip-Seq_REH_Human | 1.14601299 |
| 89 | TP53_16413492_ChIP-PET_HCT116_Human | 1.14464892 |
| 90 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.12639522 |
| 91 | * IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.12269339 |
| 92 | AR_25329375_ChIP-Seq_VCAP_Human | 1.11740013 |
| 93 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.11734611 |
| 94 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.11118997 |
| 95 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.11098150 |
| 96 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.10931791 |
| 97 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10201483 |
| 98 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10201483 |
| 99 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.09645892 |
| 100 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.09516781 |
| 101 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.08709889 |
| 102 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.08475757 |
| 103 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.07607567 |
| 104 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.07449461 |
| 105 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07381251 |
| 106 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.07375058 |
| 107 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.06983411 |
| 108 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.06943070 |
| 109 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.06471483 |
| 110 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.05897240 |
| 111 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05831911 |
| 112 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.05374517 |
| 113 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05200659 |
| 114 | * STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.04820674 |
| 115 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.04761862 |
| 116 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.04592090 |
| 117 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.04585157 |
| 118 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.03939893 |
| 119 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03455644 |
| 120 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.03260056 |
| 121 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.03071641 |
| 122 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.02916401 |
| 123 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.02791275 |
| 124 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.02022039 |
| 125 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.00643000 |
| 126 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.00549969 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.57497307 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 3.46183977 |
| 3 | MP0009046_muscle_twitch | 3.15717166 |
| 4 | MP0004270_analgesia | 2.95830407 |
| 5 | MP0001486_abnormal_startle_reflex | 2.90379269 |
| 6 | MP0005423_abnormal_somatic_nervous | 2.87730603 |
| 7 | MP0003635_abnormal_synaptic_transmissio | 2.86692660 |
| 8 | MP0000920_abnormal_myelination | 2.84774226 |
| 9 | MP0004742_abnormal_vestibular_system | 2.83285216 |
| 10 | MP0002272_abnormal_nervous_system | 2.71548613 |
| 11 | MP0009745_abnormal_behavioral_response | 2.69534269 |
| 12 | MP0002064_seizures | 2.69529603 |
| 13 | MP0003136_yellow_coat_color | 2.67429510 |
| 14 | MP0004142_abnormal_muscle_tone | 2.34034615 |
| 15 | MP0005409_darkened_coat_color | 2.33006112 |
| 16 | MP0000569_abnormal_digit_pigmentation | 2.32267135 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.23985309 |
| 18 | MP0001968_abnormal_touch/_nociception | 2.22906443 |
| 19 | MP0002572_abnormal_emotion/affect_behav | 2.21833396 |
| 20 | MP0000778_abnormal_nervous_system | 2.15436829 |
| 21 | MP0001440_abnormal_grooming_behavior | 2.15039718 |
| 22 | MP0002653_abnormal_ependyma_morphology | 2.14782063 |
| 23 | MP0002067_abnormal_sensory_capabilities | 2.13765677 |
| 24 | MP0001188_hyperpigmentation | 2.13313188 |
| 25 | MP0002063_abnormal_learning/memory/cond | 2.13081060 |
| 26 | MP0005171_absent_coat_pigmentation | 2.08545683 |
| 27 | MP0002735_abnormal_chemical_nociception | 1.98112366 |
| 28 | MP0002736_abnormal_nociception_after | 1.78808554 |
| 29 | MP0004885_abnormal_endolymph | 1.76822097 |
| 30 | MP0008569_lethality_at_weaning | 1.76348738 |
| 31 | MP0002184_abnormal_innervation | 1.72820521 |
| 32 | MP0001529_abnormal_vocalization | 1.72777355 |
| 33 | MP0001970_abnormal_pain_threshold | 1.68370027 |
| 34 | MP0003690_abnormal_glial_cell | 1.68011731 |
| 35 | MP0001485_abnormal_pinna_reflex | 1.65012340 |
| 36 | MP0001905_abnormal_dopamine_level | 1.63473112 |
| 37 | MP0001501_abnormal_sleep_pattern | 1.61380947 |
| 38 | MP0002102_abnormal_ear_morphology | 1.60863341 |
| 39 | MP0002733_abnormal_thermal_nociception | 1.59914878 |
| 40 | MP0005551_abnormal_eye_electrophysiolog | 1.59760898 |
| 41 | MP0006276_abnormal_autonomic_nervous | 1.57628495 |
| 42 | MP0002557_abnormal_social/conspecific_i | 1.55390352 |
| 43 | MP0004145_abnormal_muscle_electrophysio | 1.51491386 |
| 44 | MP0000955_abnormal_spinal_cord | 1.50980356 |
| 45 | MP0001963_abnormal_hearing_physiology | 1.47698840 |
| 46 | MP0002882_abnormal_neuron_morphology | 1.47384642 |
| 47 | MP0005645_abnormal_hypothalamus_physiol | 1.43215459 |
| 48 | MP0002638_abnormal_pupillary_reflex | 1.42969765 |
| 49 | MP0003950_abnormal_plasma_membrane | 1.41211883 |
| 50 | MP0003634_abnormal_glial_cell | 1.40719793 |
| 51 | MP0002229_neurodegeneration | 1.38424892 |
| 52 | MP0002066_abnormal_motor_capabilities/c | 1.36136043 |
| 53 | MP0003890_abnormal_embryonic-extraembry | 1.35253634 |
| 54 | MP0004924_abnormal_behavior | 1.35092581 |
| 55 | MP0005386_behavior/neurological_phenoty | 1.35092581 |
| 56 | MP0000566_synostosis | 1.34456200 |
| 57 | MP0000026_abnormal_inner_ear | 1.31155521 |
| 58 | MP0002752_abnormal_somatic_nervous | 1.28795435 |
| 59 | MP0003632_abnormal_nervous_system | 1.26229739 |
| 60 | MP0003938_abnormal_ear_development | 1.25244893 |
| 61 | MP0003329_amyloid_beta_deposits | 1.24795305 |
| 62 | MP0005646_abnormal_pituitary_gland | 1.22374620 |
| 63 | MP0004381_abnormal_hair_follicle | 1.20406582 |
| 64 | MP0008057_abnormal_DNA_replication | 1.18376058 |
| 65 | MP0003122_maternal_imprinting | 1.16016522 |
| 66 | MP0000462_abnormal_digestive_system | 1.12854730 |
| 67 | MP0003631_nervous_system_phenotype | 1.11976880 |
| 68 | MP0001502_abnormal_circadian_rhythm | 1.11552240 |
| 69 | MP0008260_abnormal_autophagy | 1.10903671 |
| 70 | MP0005167_abnormal_blood-brain_barrier | 1.09155377 |
| 71 | MP0006292_abnormal_olfactory_placode | 1.07255044 |
| 72 | MP0001986_abnormal_taste_sensitivity | 1.07084269 |
| 73 | MP0006072_abnormal_retinal_apoptosis | 1.06998495 |
| 74 | MP0001984_abnormal_olfaction | 1.06759899 |
| 75 | MP0002152_abnormal_brain_morphology | 1.05160692 |
| 76 | MP0003633_abnormal_nervous_system | 1.04285516 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 1.04265902 |
| 78 | MP0003787_abnormal_imprinting | 0.96699629 |
| 79 | MP0008877_abnormal_DNA_methylation | 0.95869064 |
| 80 | MP0005410_abnormal_fertilization | 0.89461384 |
| 81 | MP0005253_abnormal_eye_physiology | 0.89015986 |
| 82 | MP0001299_abnormal_eye_distance/ | 0.88584757 |
| 83 | MP0005195_abnormal_posterior_eye | 0.84647552 |
| 84 | MP0002909_abnormal_adrenal_gland | 0.83620278 |
| 85 | MP0004134_abnormal_chest_morphology | 0.83048535 |
| 86 | MP0004811_abnormal_neuron_physiology | 0.83015657 |
| 87 | MP0003121_genomic_imprinting | 0.82788440 |
| 88 | MP0000383_abnormal_hair_follicle | 0.80746472 |
| 89 | MP0005499_abnormal_olfactory_system | 0.80056367 |
| 90 | MP0005394_taste/olfaction_phenotype | 0.80056367 |
| 91 | MP0000534_abnormal_ureter_morphology | 0.75654453 |
| 92 | MP0004130_abnormal_muscle_cell | 0.74574307 |
| 93 | MP0010678_abnormal_skin_adnexa | 0.74272337 |
| 94 | MP0009379_abnormal_foot_pigmentation | 0.73553465 |
| 95 | MP0005623_abnormal_meninges_morphology | 0.72394048 |
| 96 | MP0001177_atelectasis | 0.72053868 |
| 97 | MP0009780_abnormal_chondrocyte_physiolo | 0.71367415 |
| 98 | MP0009250_abnormal_appendicular_skeleto | 0.71020749 |
| 99 | MP0001661_extended_life_span | 0.70615975 |
| 100 | MP0003137_abnormal_impulse_conducting | 0.70018405 |
| 101 | MP0005379_endocrine/exocrine_gland_phen | 0.68419148 |
| 102 | MP0004147_increased_porphyrin_level | 0.68369475 |
| 103 | MP0001346_abnormal_lacrimal_gland | 0.68116878 |
| 104 | MP0004043_abnormal_pH_regulation | 0.67871604 |
| 105 | MP0002928_abnormal_bile_duct | 0.66798357 |
| 106 | MP0010769_abnormal_survival | 0.66511751 |
| 107 | MP0004858_abnormal_nervous_system | 0.65031012 |
| 108 | MP0003861_abnormal_nervous_system | 0.64768889 |
| 109 | MP0003937_abnormal_limbs/digits/tail_de | 0.64554805 |
| 110 | MP0002082_postnatal_lethality | 0.64217155 |
| 111 | MP0010770_preweaning_lethality | 0.64217155 |
| 112 | MP0002822_catalepsy | 0.63766825 |
| 113 | MP0010768_mortality/aging | 0.63365527 |
| 114 | MP0005174_abnormal_tail_pigmentation | 0.63339570 |
| 115 | MP0002249_abnormal_larynx_morphology | 0.62528986 |
| 116 | MP0000427_abnormal_hair_cycle | 0.62288993 |
| 117 | MP0000015_abnormal_ear_pigmentation | 0.61908356 |
| 118 | MP0003879_abnormal_hair_cell | 0.60890430 |
| 119 | MP0003183_abnormal_peptide_metabolism | 0.60821281 |
| 120 | MP0002233_abnormal_nose_morphology | 0.60784914 |
| 121 | MP0002938_white_spotting | 0.60780054 |
| 122 | MP0002069_abnormal_eating/drinking_beha | 0.60762673 |
| 123 | MP0001943_abnormal_respiration | 0.59894323 |
| 124 | MP0002081_perinatal_lethality | 0.59300317 |
| 125 | MP0002277_abnormal_respiratory_mucosa | 0.58395276 |
| 126 | MP0005187_abnormal_penis_morphology | 0.56774662 |
| 127 | MP0003119_abnormal_digestive_system | 0.55896581 |
| 128 | MP0003385_abnormal_body_wall | 0.55781977 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 5.15924812 |
| 2 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 4.30002666 |
| 3 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 4.30002666 |
| 4 | Genetic anticipation (HP:0003743) | 4.22507061 |
| 5 | Neurofibrillary tangles (HP:0002185) | 3.79772066 |
| 6 | Abnormality of the corticospinal tract (HP:0002492) | 3.69212374 |
| 7 | Parakeratosis (HP:0001036) | 3.50926825 |
| 8 | Progressive cerebellar ataxia (HP:0002073) | 3.48877163 |
| 9 | Myokymia (HP:0002411) | 3.48439803 |
| 10 | Febrile seizures (HP:0002373) | 3.48114619 |
| 11 | Focal seizures (HP:0007359) | 3.47707337 |
| 12 | Atonic seizures (HP:0010819) | 3.42664805 |
| 13 | Broad-based gait (HP:0002136) | 3.19036811 |
| 14 | Peripheral hypomyelination (HP:0007182) | 3.17923755 |
| 15 | Action tremor (HP:0002345) | 3.17271502 |
| 16 | Gaze-evoked nystagmus (HP:0000640) | 3.16776496 |
| 17 | Epileptic encephalopathy (HP:0200134) | 3.10796428 |
| 18 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.10124137 |
| 19 | Absent/shortened dynein arms (HP:0200106) | 3.10124137 |
| 20 | Postural instability (HP:0002172) | 3.09662041 |
| 21 | Dysmetria (HP:0001310) | 3.08795926 |
| 22 | Scanning speech (HP:0002168) | 3.07422346 |
| 23 | Septo-optic dysplasia (HP:0100842) | 3.01327799 |
| 24 | Hemiparesis (HP:0001269) | 2.97217111 |
| 25 | Supranuclear gaze palsy (HP:0000605) | 2.90817114 |
| 26 | Retinal dysplasia (HP:0007973) | 2.86174457 |
| 27 | Sensory axonal neuropathy (HP:0003390) | 2.83159412 |
| 28 | Abnormal ciliary motility (HP:0012262) | 2.82551798 |
| 29 | Hyperventilation (HP:0002883) | 2.81341603 |
| 30 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.79022556 |
| 31 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.75867387 |
| 32 | Spastic gait (HP:0002064) | 2.73029065 |
| 33 | Absent septum pellucidum (HP:0001331) | 2.69986006 |
| 34 | Abnormality of cochlea (HP:0000375) | 2.69653846 |
| 35 | Onion bulb formation (HP:0003383) | 2.69371214 |
| 36 | Dysdiadochokinesis (HP:0002075) | 2.69323994 |
| 37 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.67205580 |
| 38 | Cerebral inclusion bodies (HP:0100314) | 2.62866080 |
| 39 | Alacrima (HP:0000522) | 2.61403725 |
| 40 | Intention tremor (HP:0002080) | 2.60947766 |
| 41 | Morphological abnormality of the inner ear (HP:0011390) | 2.54372186 |
| 42 | Absent speech (HP:0001344) | 2.51635060 |
| 43 | Dialeptic seizures (HP:0011146) | 2.46437352 |
| 44 | Abnormality of the septum pellucidum (HP:0007375) | 2.45776102 |
| 45 | Generalized tonic-clonic seizures (HP:0002069) | 2.44753740 |
| 46 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.40809931 |
| 47 | Absence seizures (HP:0002121) | 2.34974543 |
| 48 | Synostosis involving the elbow (HP:0003938) | 2.30053342 |
| 49 | Humeroradial synostosis (HP:0003041) | 2.30053342 |
| 50 | Drooling (HP:0002307) | 2.26189023 |
| 51 | Excessive salivation (HP:0003781) | 2.26189023 |
| 52 | Decreased lacrimation (HP:0000633) | 2.25854139 |
| 53 | Split foot (HP:0001839) | 2.24546174 |
| 54 | Ankle clonus (HP:0011448) | 2.22083966 |
| 55 | White forelock (HP:0002211) | 2.20226516 |
| 56 | Termporal pattern (HP:0011008) | 2.19052768 |
| 57 | Insidious onset (HP:0003587) | 2.19052768 |
| 58 | Abnormality of binocular vision (HP:0011514) | 2.19000750 |
| 59 | Diplopia (HP:0000651) | 2.19000750 |
| 60 | Urethral obstruction (HP:0000796) | 2.18593431 |
| 61 | Metabolic alkalosis (HP:0200114) | 2.16817960 |
| 62 | Aplasia involving bones of the extremities (HP:0009825) | 2.13713296 |
| 63 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.13713296 |
| 64 | Aplasia of the phalanges of the hand (HP:0009802) | 2.13713296 |
| 65 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.12932898 |
| 66 | Status epilepticus (HP:0002133) | 2.12358196 |
| 67 | Epileptiform EEG discharges (HP:0011182) | 2.12280030 |
| 68 | Akinesia (HP:0002304) | 2.11395427 |
| 69 | Obstructive sleep apnea (HP:0002870) | 2.10537377 |
| 70 | Progressive inability to walk (HP:0002505) | 2.10074091 |
| 71 | Abnormality of the lower motor neuron (HP:0002366) | 2.09449202 |
| 72 | Truncal ataxia (HP:0002078) | 2.09424682 |
| 73 | Patchy hypopigmentation of hair (HP:0011365) | 2.06486290 |
| 74 | Abnormality of the 4th metacarpal (HP:0010012) | 2.06038609 |
| 75 | Gait imbalance (HP:0002141) | 2.05716465 |
| 76 | Visual hallucinations (HP:0002367) | 2.05679396 |
| 77 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.05661896 |
| 78 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.05661896 |
| 79 | Clumsiness (HP:0002312) | 2.05052160 |
| 80 | Cupped ear (HP:0000378) | 2.04874002 |
| 81 | Optic nerve hypoplasia (HP:0000609) | 2.01856412 |
| 82 | Fibular hypoplasia (HP:0003038) | 2.00762351 |
| 83 | Impaired vibratory sensation (HP:0002495) | 1.99453145 |
| 84 | Polydipsia (HP:0001959) | 1.99370159 |
| 85 | Abnormal drinking behavior (HP:0030082) | 1.99370159 |
| 86 | Esotropia (HP:0000565) | 1.98405030 |
| 87 | Urinary urgency (HP:0000012) | 1.97798434 |
| 88 | Stereotypic behavior (HP:0000733) | 1.97554589 |
| 89 | EEG with generalized epileptiform discharges (HP:0011198) | 1.96905495 |
| 90 | Impaired smooth pursuit (HP:0007772) | 1.96692017 |
| 91 | Thickened helices (HP:0000391) | 1.96444691 |
| 92 | Hypoplastic pelvis (HP:0008839) | 1.93571917 |
| 93 | Blue irides (HP:0000635) | 1.93047416 |
| 94 | Aplasia cutis congenita (HP:0001057) | 1.90873396 |
| 95 | Gastroesophageal reflux (HP:0002020) | 1.90253700 |
| 96 | True hermaphroditism (HP:0010459) | 1.90113648 |
| 97 | Mixed hearing impairment (HP:0000410) | 1.89666298 |
| 98 | Hypsarrhythmia (HP:0002521) | 1.89627402 |
| 99 | Hypophosphatemic rickets (HP:0004912) | 1.88978035 |
| 100 | Abnormality of the ischium (HP:0003174) | 1.87681717 |
| 101 | Slow saccadic eye movements (HP:0000514) | 1.87131280 |
| 102 | Limb dystonia (HP:0002451) | 1.86678851 |
| 103 | Hemiplegia (HP:0002301) | 1.86273999 |
| 104 | Decreased central vision (HP:0007663) | 1.86076506 |
| 105 | Oligodactyly (hands) (HP:0001180) | 1.85738658 |
| 106 | Oligodactyly (HP:0012165) | 1.85531565 |
| 107 | Anomalous pulmonary venous return (HP:0010772) | 1.85510028 |
| 108 | Congenital sensorineural hearing impairment (HP:0008527) | 1.85480692 |
| 109 | Chronic hepatic failure (HP:0100626) | 1.84945182 |
| 110 | Aqueductal stenosis (HP:0002410) | 1.84544924 |
| 111 | Abnormality of salivation (HP:0100755) | 1.83671253 |
| 112 | Widely spaced teeth (HP:0000687) | 1.83180132 |
| 113 | Protruding tongue (HP:0010808) | 1.82413720 |
| 114 | Hypomagnesemia (HP:0002917) | 1.82372443 |
| 115 | Ulnar claw (HP:0001178) | 1.81871924 |
| 116 | Cutaneous finger syndactyly (HP:0010554) | 1.80816483 |
| 117 | Partial agenesis of the corpus callosum (HP:0001338) | 1.79804306 |
| 118 | Abnormal hair whorl (HP:0010721) | 1.79358669 |
| 119 | Lower limb muscle weakness (HP:0007340) | 1.79176690 |
| 120 | Hypoplasia of the iris (HP:0007676) | 1.78871095 |
| 121 | Anteriorly placed anus (HP:0001545) | 1.78406406 |
| 122 | Myelomeningocele (HP:0002475) | 1.77768604 |
| 123 | Abnormal eating behavior (HP:0100738) | 1.77389306 |
| 124 | Overfolded helix (HP:0000396) | 1.76941664 |
| 125 | Generalized myoclonic seizures (HP:0002123) | 1.75401326 |
| 126 | Bradykinesia (HP:0002067) | 1.74958327 |
| 127 | Increased circulating renin level (HP:0000848) | 1.74712042 |
| 128 | Supernumerary spleens (HP:0009799) | 1.74584579 |
| 129 | Steppage gait (HP:0003376) | 1.74388195 |
| 130 | Fetal akinesia sequence (HP:0001989) | 1.73877174 |
| 131 | Neoplasm of the heart (HP:0100544) | 1.73436123 |
| 132 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.72888224 |
| 133 | Chin dimple (HP:0010751) | 1.72082340 |
| 134 | Abnormality of the astrocytes (HP:0100707) | 1.70621123 |
| 135 | Astrocytoma (HP:0009592) | 1.70621123 |
| 136 | Anxiety (HP:0000739) | 1.70442037 |
| 137 | Specific learning disability (HP:0001328) | 1.68680968 |
| 138 | Hepatoblastoma (HP:0002884) | 1.68020841 |
| 139 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.66723476 |
| 140 | Vertebral arch anomaly (HP:0008438) | 1.66191847 |
| 141 | Polyphagia (HP:0002591) | 1.65697733 |
| 142 | Hypoplasia of the corpus callosum (HP:0002079) | 1.65363846 |
| 143 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.62861043 |
| 144 | Pancreatic cysts (HP:0001737) | 1.62768957 |
| 145 | Amyotrophic lateral sclerosis (HP:0007354) | 1.60579503 |
| 146 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.60447527 |
| 147 | Vaginal atresia (HP:0000148) | 1.60346295 |
| 148 | Pheochromocytoma (HP:0002666) | 1.60032196 |
| 149 | Bowel incontinence (HP:0002607) | 1.59828013 |
| 150 | Obsessive-compulsive behavior (HP:0000722) | 1.59439750 |
| 151 | Genital tract atresia (HP:0001827) | 1.58382342 |
| 152 | Anophthalmia (HP:0000528) | 1.57859915 |
| 153 | Midline defect of the nose (HP:0004122) | 1.57139795 |
| 154 | Renal hypoplasia (HP:0000089) | 1.56662951 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 4.36276972 |
| 2 | STK39 | 3.93803873 |
| 3 | FRK | 3.22228054 |
| 4 | TNIK | 3.14551723 |
| 5 | OXSR1 | 3.04518516 |
| 6 | PRKD3 | 2.79361181 |
| 7 | PNCK | 2.60009481 |
| 8 | NTRK3 | 2.43462780 |
| 9 | PKN1 | 2.37927141 |
| 10 | STK38L | 2.24095669 |
| 11 | MARK1 | 2.11430424 |
| 12 | BCR | 1.98534046 |
| 13 | EPHB1 | 1.96517775 |
| 14 | WNK1 | 1.86551239 |
| 15 | CDK19 | 1.81362428 |
| 16 | EPHA4 | 1.66356204 |
| 17 | MAPKAPK5 | 1.65668049 |
| 18 | MAP2K7 | 1.60607146 |
| 19 | NEK6 | 1.58437689 |
| 20 | WNK4 | 1.52509659 |
| 21 | NTRK2 | 1.50322729 |
| 22 | SGK2 | 1.45824225 |
| 23 | BMPR1B | 1.43707167 |
| 24 | BRD4 | 1.41918801 |
| 25 | CAMKK1 | 1.38745345 |
| 26 | MAPK13 | 1.37546492 |
| 27 | PAK6 | 1.37223761 |
| 28 | MAP3K4 | 1.36638066 |
| 29 | MKNK2 | 1.36515038 |
| 30 | FGR | 1.32217273 |
| 31 | BLK | 1.30903937 |
| 32 | STK38 | 1.27482662 |
| 33 | CAMK2B | 1.25757522 |
| 34 | UHMK1 | 1.23307623 |
| 35 | PBK | 1.22794716 |
| 36 | GRK7 | 1.20468172 |
| 37 | NTRK1 | 1.19894434 |
| 38 | FES | 1.14662225 |
| 39 | PRPF4B | 1.13659933 |
| 40 | MUSK | 1.12357707 |
| 41 | INSRR | 1.12190758 |
| 42 | SGK223 | 1.11189542 |
| 43 | SGK494 | 1.11189542 |
| 44 | CAMK2A | 1.10478032 |
| 45 | CAMK1G | 1.08827334 |
| 46 | CSNK1A1L | 1.07693757 |
| 47 | ROCK2 | 1.03877157 |
| 48 | ACVR1B | 1.01823163 |
| 49 | CSNK1G3 | 1.00704243 |
| 50 | PHKG2 | 0.99168552 |
| 51 | PHKG1 | 0.99168552 |
| 52 | ADRBK2 | 0.98967831 |
| 53 | IRAK2 | 0.98767637 |
| 54 | CAMKK2 | 0.98657511 |
| 55 | CDK5 | 0.98554709 |
| 56 | FGFR2 | 0.97538569 |
| 57 | CAMK2D | 0.97490952 |
| 58 | MAP3K13 | 0.97470101 |
| 59 | CSNK1G2 | 0.93353736 |
| 60 | CAMK4 | 0.92650373 |
| 61 | PRKCE | 0.91759354 |
| 62 | CAMK1D | 0.91257886 |
| 63 | KSR2 | 0.88471393 |
| 64 | RIPK4 | 0.87617427 |
| 65 | CSNK1G1 | 0.85770009 |
| 66 | MINK1 | 0.85088598 |
| 67 | PINK1 | 0.82412225 |
| 68 | GRK5 | 0.82347000 |
| 69 | MKNK1 | 0.81402735 |
| 70 | PAK3 | 0.80024185 |
| 71 | PRKCH | 0.79951398 |
| 72 | SGK3 | 0.79878386 |
| 73 | STK11 | 0.79833140 |
| 74 | CAMK2G | 0.79178695 |
| 75 | RET | 0.79021307 |
| 76 | DYRK2 | 0.76446940 |
| 77 | GRK1 | 0.75657713 |
| 78 | BMPR2 | 0.75262116 |
| 79 | KSR1 | 0.74762136 |
| 80 | AKT3 | 0.73803749 |
| 81 | MARK2 | 0.73399092 |
| 82 | PLK2 | 0.71200518 |
| 83 | DYRK1A | 0.70901122 |
| 84 | CDK3 | 0.69679988 |
| 85 | PRKG1 | 0.69030101 |
| 86 | PRKCQ | 0.68811487 |
| 87 | EPHA3 | 0.68386180 |
| 88 | MELK | 0.66153058 |
| 89 | PRKCG | 0.65946511 |
| 90 | MAP3K7 | 0.65841824 |
| 91 | ERBB4 | 0.65173546 |
| 92 | RIPK1 | 0.64674293 |
| 93 | ICK | 0.64444497 |
| 94 | STK16 | 0.64385592 |
| 95 | SIK2 | 0.63263792 |
| 96 | MAPK10 | 0.63082555 |
| 97 | CLK1 | 0.62279271 |
| 98 | SGK1 | 0.61332464 |
| 99 | MAP2K4 | 0.60197733 |
| 100 | IRAK1 | 0.60134814 |
| 101 | MAP3K9 | 0.58131872 |
| 102 | TYRO3 | 0.57744148 |
| 103 | TNK2 | 0.57465601 |
| 104 | FYN | 0.57059895 |
| 105 | ERBB2 | 0.55513278 |
| 106 | CDK15 | 0.55506020 |
| 107 | CDK14 | 0.55416774 |
| 108 | CAMK1 | 0.54912108 |
| 109 | YES1 | 0.54895319 |
| 110 | PDGFRB | 0.54200507 |
| 111 | CDK18 | 0.53575958 |
| 112 | RAF1 | 0.53228456 |
| 113 | NLK | 0.52874422 |
| 114 | MAPK15 | 0.52350052 |
| 115 | CDK11A | 0.50112856 |
| 116 | PDGFRA | 0.49164254 |
| 117 | DAPK2 | 0.48636714 |
| 118 | PRKACA | 0.47764880 |
| 119 | MET | 0.47363867 |
| 120 | MST4 | 0.46309793 |
| 121 | PDPK1 | 0.45809891 |
| 122 | LIMK1 | 0.44328577 |
| 123 | PIK3CA | 0.43992546 |
| 124 | RPS6KA3 | 0.42893402 |
| 125 | WNK3 | 0.42733728 |
| 126 | PRKACB | 0.42406076 |
| 127 | ADRBK1 | 0.42240111 |
| 128 | CDK12 | 0.42152009 |
| 129 | CSNK1A1 | 0.40370330 |
| 130 | CSNK1D | 0.40316953 |
| 131 | PRKCZ | 0.38521897 |
| 132 | FER | 0.37438294 |
| 133 | BMX | 0.37414390 |
| 134 | PRKAA1 | 0.37376217 |
| 135 | MAPK12 | 0.35195158 |
| 136 | GSK3B | 0.32338296 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.77556410 |
| 2 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.73033059 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.61153288 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.59130961 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.43376770 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.34514598 |
| 7 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.05504883 |
| 8 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.04702217 |
| 9 | Taste transduction_Homo sapiens_hsa04742 | 2.02315073 |
| 10 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.99030084 |
| 11 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.98344576 |
| 12 | Circadian entrainment_Homo sapiens_hsa04713 | 1.93130965 |
| 13 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.90250718 |
| 14 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.87191483 |
| 15 | Long-term depression_Homo sapiens_hsa04730 | 1.86611998 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.82697445 |
| 17 | Axon guidance_Homo sapiens_hsa04360 | 1.81937049 |
| 18 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.78161247 |
| 19 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.76806750 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.72130489 |
| 21 | Phototransduction_Homo sapiens_hsa04744 | 1.65863931 |
| 22 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.62698781 |
| 23 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.56263924 |
| 24 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.47868765 |
| 25 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.44551525 |
| 26 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.42370441 |
| 27 | Long-term potentiation_Homo sapiens_hsa04720 | 1.42180412 |
| 28 | Olfactory transduction_Homo sapiens_hsa04740 | 1.40390257 |
| 29 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.38891780 |
| 30 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.38139270 |
| 31 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.36520490 |
| 32 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.36027292 |
| 33 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.34836116 |
| 34 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.28371076 |
| 35 | Cocaine addiction_Homo sapiens_hsa05030 | 1.24338475 |
| 36 | Renin secretion_Homo sapiens_hsa04924 | 1.19832888 |
| 37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.19238143 |
| 38 | Insulin secretion_Homo sapiens_hsa04911 | 1.18190012 |
| 39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.15460021 |
| 40 | Glioma_Homo sapiens_hsa05214 | 1.10819142 |
| 41 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.06916756 |
| 42 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.03868519 |
| 43 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.02819372 |
| 44 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.02159662 |
| 45 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.00830709 |
| 46 | Bile secretion_Homo sapiens_hsa04976 | 0.99322547 |
| 47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.98147546 |
| 48 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.96619640 |
| 49 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.94718954 |
| 50 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.93828288 |
| 51 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.93712268 |
| 52 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.92319328 |
| 53 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.91646944 |
| 54 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.90379236 |
| 55 | Circadian rhythm_Homo sapiens_hsa04710 | 0.89876389 |
| 56 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.88129106 |
| 57 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.87198152 |
| 58 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.86620162 |
| 59 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.86276597 |
| 60 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.85100215 |
| 61 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.84988112 |
| 62 | Gap junction_Homo sapiens_hsa04540 | 0.84849434 |
| 63 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.83745181 |
| 64 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.83009195 |
| 65 | Parkinsons disease_Homo sapiens_hsa05012 | 0.81792132 |
| 66 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.81529109 |
| 67 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.81352417 |
| 68 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.80905679 |
| 69 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.80510729 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.79688722 |
| 71 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.77340812 |
| 72 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.75566683 |
| 73 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.75514691 |
| 74 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.73715551 |
| 75 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.72907206 |
| 76 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.72675675 |
| 77 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.72253977 |
| 78 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.70662954 |
| 79 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.69624313 |
| 80 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.68599787 |
| 81 | Melanogenesis_Homo sapiens_hsa04916 | 0.68448565 |
| 82 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.68349515 |
| 83 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.67788841 |
| 84 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67380631 |
| 85 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.67241844 |
| 86 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.65736037 |
| 87 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.63679379 |
| 88 | Mineral absorption_Homo sapiens_hsa04978 | 0.63159642 |
| 89 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.63155590 |
| 90 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.63116099 |
| 91 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.62981083 |
| 92 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.62479489 |
| 93 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.61739270 |
| 94 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.61714918 |
| 95 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.61217295 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.60532639 |
| 97 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.59779945 |
| 98 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.59100547 |
| 99 | Colorectal cancer_Homo sapiens_hsa05210 | 0.58866486 |
| 100 | ABC transporters_Homo sapiens_hsa02010 | 0.58818709 |
| 101 | Endometrial cancer_Homo sapiens_hsa05213 | 0.58784994 |
| 102 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.58733589 |
| 103 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57418560 |
| 104 | Huntingtons disease_Homo sapiens_hsa05016 | 0.57074690 |
| 105 | Lysine degradation_Homo sapiens_hsa00310 | 0.55924694 |
| 106 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.54151629 |
| 107 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.53958800 |
| 108 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.53383505 |
| 109 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.51775462 |
| 110 | Histidine metabolism_Homo sapiens_hsa00340 | 0.51288549 |
| 111 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.51031084 |
| 112 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.50719133 |
| 113 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50549502 |
| 114 | Phagosome_Homo sapiens_hsa04145 | 0.49042128 |
| 115 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47292980 |
| 116 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.47160168 |
| 117 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.46005476 |
| 118 | Tight junction_Homo sapiens_hsa04530 | 0.42885580 |
| 119 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.42176595 |
| 120 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.41772619 |
| 121 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.41378110 |
| 122 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.41120009 |
| 123 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.40942164 |
| 124 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.40020717 |
| 125 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.39670287 |
| 126 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.39048474 |
| 127 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.38763865 |
| 128 | Melanoma_Homo sapiens_hsa05218 | 0.37361844 |
| 129 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.35805099 |
| 130 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.35658309 |
| 131 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.35195971 |
| 132 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.35127154 |

