

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.18538675 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.02385529 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.01764748 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.66518334 |
| 5 | layer formation in cerebral cortex (GO:0021819) | 4.42782788 |
| 6 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.20719971 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.17554713 |
| 8 | vocalization behavior (GO:0071625) | 4.15386256 |
| 9 | sodium ion export (GO:0071436) | 3.92328105 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.89478895 |
| 11 | regulation of synapse structural plasticity (GO:0051823) | 3.87208309 |
| 12 | glutamate secretion (GO:0014047) | 3.83881275 |
| 13 | synaptic vesicle exocytosis (GO:0016079) | 3.72927439 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.70761187 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.70033869 |
| 16 | activation of protein kinase A activity (GO:0034199) | 3.69571027 |
| 17 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.68719263 |
| 18 | dendritic spine morphogenesis (GO:0060997) | 3.68262539 |
| 19 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.65893772 |
| 20 | cell communication by electrical coupling (GO:0010644) | 3.59806894 |
| 21 | exploration behavior (GO:0035640) | 3.57537589 |
| 22 | proline transport (GO:0015824) | 3.54784352 |
| 23 | cerebellar granule cell differentiation (GO:0021707) | 3.52805101 |
| 24 | cellular potassium ion homeostasis (GO:0030007) | 3.52322484 |
| 25 | neurotransmitter secretion (GO:0007269) | 3.44124820 |
| 26 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.41929164 |
| 27 | postsynaptic membrane organization (GO:0001941) | 3.40848307 |
| 28 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.40768143 |
| 29 | neuromuscular process controlling balance (GO:0050885) | 3.40318451 |
| 30 | plasma membrane repair (GO:0001778) | 3.34351935 |
| 31 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.32790484 |
| 32 | regulation of synaptic vesicle transport (GO:1902803) | 3.25173478 |
| 33 | protein localization to synapse (GO:0035418) | 3.24423556 |
| 34 | establishment of nucleus localization (GO:0040023) | 3.24223173 |
| 35 | cerebellar Purkinje cell layer development (GO:0021680) | 3.17779335 |
| 36 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.17450540 |
| 37 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.13873080 |
| 38 | dendrite morphogenesis (GO:0048813) | 3.10033450 |
| 39 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.08942917 |
| 40 | gamma-aminobutyric acid transport (GO:0015812) | 3.08763294 |
| 41 | positive regulation of synapse maturation (GO:0090129) | 3.04564914 |
| 42 | semaphorin-plexin signaling pathway (GO:0071526) | 3.04030740 |
| 43 | neuronal action potential propagation (GO:0019227) | 2.97481943 |
| 44 | glycine transport (GO:0015816) | 2.95798810 |
| 45 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.90589296 |
| 46 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.88435646 |
| 47 | cell migration in hindbrain (GO:0021535) | 2.88246263 |
| 48 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.87094128 |
| 49 | amino acid import (GO:0043090) | 2.85197396 |
| 50 | camera-type eye morphogenesis (GO:0048593) | 2.83681507 |
| 51 | axon extension (GO:0048675) | 2.83647986 |
| 52 | long-term memory (GO:0007616) | 2.83117583 |
| 53 | synaptic transmission, glutamatergic (GO:0035249) | 2.82982775 |
| 54 | regulation of ARF protein signal transduction (GO:0032012) | 2.81885169 |
| 55 | cell communication involved in cardiac conduction (GO:0086065) | 2.79484511 |
| 56 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.79130888 |
| 57 | myelination in peripheral nervous system (GO:0022011) | 2.79113603 |
| 58 | peripheral nervous system axon ensheathment (GO:0032292) | 2.79113603 |
| 59 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.78744737 |
| 60 | vesicle transport along microtubule (GO:0047496) | 2.77984794 |
| 61 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.77835617 |
| 62 | auditory behavior (GO:0031223) | 2.77818773 |
| 63 | neuronal ion channel clustering (GO:0045161) | 2.77247040 |
| 64 | prepulse inhibition (GO:0060134) | 2.74169062 |
| 65 | neuron cell-cell adhesion (GO:0007158) | 2.73696466 |
| 66 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.73607418 |
| 67 | potassium ion import (GO:0010107) | 2.72613886 |
| 68 | membrane depolarization during action potential (GO:0086010) | 2.71943685 |
| 69 | glutamate receptor signaling pathway (GO:0007215) | 2.71087476 |
| 70 | regulation of synapse maturation (GO:0090128) | 2.69216302 |
| 71 | cell-cell junction maintenance (GO:0045217) | 2.68893148 |
| 72 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.68675845 |
| 73 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.68454073 |
| 74 | innervation (GO:0060384) | 2.68062777 |
| 75 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.67590592 |
| 76 | adherens junction assembly (GO:0034333) | 2.67553258 |
| 77 | dendritic spine organization (GO:0097061) | 2.66676523 |
| 78 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.66314793 |
| 79 | axon extension involved in axon guidance (GO:0048846) | 2.64921939 |
| 80 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.64921939 |
| 81 | neuromuscular process controlling posture (GO:0050884) | 2.64481322 |
| 82 | response to auditory stimulus (GO:0010996) | 2.62977591 |
| 83 | L-amino acid import (GO:0043092) | 2.62847347 |
| 84 | alanine transport (GO:0032328) | 2.62829369 |
| 85 | cellular sodium ion homeostasis (GO:0006883) | 2.62442865 |
| 86 | neurotransmitter transport (GO:0006836) | 2.61715471 |
| 87 | mating behavior (GO:0007617) | 2.60650054 |
| 88 | positive regulation of dendritic spine development (GO:0060999) | 2.60632509 |
| 89 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.60033696 |
| 90 | synaptic vesicle endocytosis (GO:0048488) | 2.59989124 |
| 91 | regulation of synaptic plasticity (GO:0048167) | 2.58769388 |
| 92 | neuron-neuron synaptic transmission (GO:0007270) | 2.57140986 |
| 93 | regulation of postsynaptic membrane potential (GO:0060078) | 2.56102733 |
| 94 | neuromuscular process (GO:0050905) | 2.55755689 |
| 95 | potassium ion homeostasis (GO:0055075) | 2.55576333 |
| 96 | positive regulation of membrane potential (GO:0045838) | 2.55181287 |
| 97 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.54344280 |
| 98 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.53747517 |
| 99 | positive regulation of fibroblast migration (GO:0010763) | 2.53135510 |
| 100 | neuron projection extension (GO:1990138) | 2.52215434 |
| 101 | apical protein localization (GO:0045176) | 2.52120822 |
| 102 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.52015302 |
| 103 | protein retention in ER lumen (GO:0006621) | 2.51213168 |
| 104 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.49991057 |
| 105 | * neuron recognition (GO:0008038) | 2.49821178 |
| 106 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.49307469 |
| 107 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.48893478 |
| 108 | protein heterotrimerization (GO:0070208) | 2.48080048 |
| 109 | organelle transport along microtubule (GO:0072384) | 2.47644706 |
| 110 | synapse organization (GO:0050808) | 2.46373520 |
| 111 | positive regulation of dendrite development (GO:1900006) | 2.45902896 |
| 112 | stress fiber assembly (GO:0043149) | 2.44646989 |
| 113 | membrane repolarization (GO:0086009) | 2.43567733 |
| 114 | convergent extension (GO:0060026) | 2.43007884 |
| 115 | regulation of neurotransmitter levels (GO:0001505) | 2.42479809 |
| 116 | neuromuscular junction development (GO:0007528) | 2.41366561 |
| 117 | suckling behavior (GO:0001967) | 2.40082452 |
| 118 | * axonal fasciculation (GO:0007413) | 2.39945433 |
| 119 | establishment of mitochondrion localization (GO:0051654) | 2.39650872 |
| 120 | protein targeting to plasma membrane (GO:0072661) | 2.38673343 |
| 121 | regulation of establishment of planar polarity (GO:0090175) | 2.38159146 |
| 122 | dopamine receptor signaling pathway (GO:0007212) | 2.38059029 |
| 123 | developmental cell growth (GO:0048588) | 2.37886775 |
| 124 | regulation of neurotransmitter secretion (GO:0046928) | 2.37101326 |
| 125 | regulation of vesicle fusion (GO:0031338) | 2.37018649 |
| 126 | negative regulation of catenin import into nucleus (GO:0035414) | 2.35784506 |
| 127 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.35771735 |
| 128 | axon cargo transport (GO:0008088) | 2.35449489 |
| 129 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.35430038 |
| 130 | cellular response to catecholamine stimulus (GO:0071870) | 2.35268375 |
| 131 | cellular response to monoamine stimulus (GO:0071868) | 2.35268375 |
| 132 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.34310098 |
| 133 | endothelial cell chemotaxis (GO:0035767) | 2.32420728 |
| 134 | cell-substrate adherens junction assembly (GO:0007045) | 2.32378510 |
| 135 | focal adhesion assembly (GO:0048041) | 2.32378510 |
| 136 | presynaptic membrane assembly (GO:0097105) | 2.30573263 |
| 137 | positive regulation of synapse assembly (GO:0051965) | 2.28244969 |
| 138 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.28224180 |
| 139 | basement membrane organization (GO:0071711) | 2.28094758 |
| 140 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.27436677 |
| 141 | mitochondrion transport along microtubule (GO:0047497) | 2.27436677 |
| 142 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.26599707 |
| 143 | neural tube development (GO:0021915) | 2.24764641 |
| 144 | regulation of early endosome to late endosome transport (GO:2000641) | 2.24211848 |
| 145 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.23298227 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.38622778 |
| 2 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.65203200 |
| 3 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.64504652 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.62417520 |
| 5 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.54670377 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.54670377 |
| 7 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.50434945 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.43566845 |
| 9 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.38638139 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.33635450 |
| 11 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.28700674 |
| 12 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.20561066 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.16301568 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.13256168 |
| 15 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.10565666 |
| 16 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.09576900 |
| 17 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.08629618 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.06851557 |
| 19 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.00778045 |
| 20 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.99960383 |
| 21 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.96974523 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.96060609 |
| 23 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.92358914 |
| 24 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.91190691 |
| 25 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.90091040 |
| 26 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.89995784 |
| 27 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.89947440 |
| 28 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.88540457 |
| 29 | KDM2B_26808549_Chip-Seq_K562_Human | 1.87909611 |
| 30 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.85082939 |
| 31 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.80422866 |
| 32 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.73235272 |
| 33 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.73095345 |
| 34 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.64787409 |
| 35 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.64203489 |
| 36 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.56693170 |
| 37 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.56361807 |
| 38 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.52144597 |
| 39 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.51052503 |
| 40 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.49618450 |
| 41 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.48815999 |
| 42 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.46810323 |
| 43 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.46755417 |
| 44 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.45533236 |
| 45 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.42486244 |
| 46 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.38573419 |
| 47 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.36624055 |
| 48 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.34109182 |
| 49 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.33879487 |
| 50 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.33156446 |
| 51 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.32683336 |
| 52 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.31985136 |
| 53 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.29983251 |
| 54 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.27355988 |
| 55 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.25408808 |
| 56 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.25068590 |
| 57 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.24761211 |
| 58 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.23918304 |
| 59 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.23833356 |
| 60 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.23492604 |
| 61 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.22537744 |
| 62 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.21618183 |
| 63 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.20659463 |
| 64 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.20389283 |
| 65 | * AR_19668381_ChIP-Seq_PC3_Human | 1.20336907 |
| 66 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.19544555 |
| 67 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.18104114 |
| 68 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.18038092 |
| 69 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.16473048 |
| 70 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.13301257 |
| 71 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.12351539 |
| 72 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.09909662 |
| 73 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.08576095 |
| 74 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.07307483 |
| 75 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.07267862 |
| 76 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.04902723 |
| 77 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.04375074 |
| 78 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.04349343 |
| 79 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.04060579 |
| 80 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.03912439 |
| 81 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.03012150 |
| 82 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.02588349 |
| 83 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.02213712 |
| 84 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.01403346 |
| 85 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.01047950 |
| 86 | TP53_16413492_ChIP-PET_HCT116_Human | 1.00899220 |
| 87 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.00031111 |
| 88 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.99947712 |
| 89 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.99919077 |
| 90 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99880450 |
| 91 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.98903306 |
| 92 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.98761956 |
| 93 | * ZNF274_21170338_ChIP-Seq_K562_Hela | 0.98536224 |
| 94 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.98442678 |
| 95 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.98432209 |
| 96 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.98148418 |
| 97 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.97907519 |
| 98 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97516370 |
| 99 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.97473935 |
| 100 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.97344804 |
| 101 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.97342900 |
| 102 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.97111320 |
| 103 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.96706988 |
| 104 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.95851374 |
| 105 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.94879887 |
| 106 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.94723344 |
| 107 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.93766994 |
| 108 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.93257161 |
| 109 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.93257161 |
| 110 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.91994020 |
| 111 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.91548904 |
| 112 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.91205410 |
| 113 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.90879939 |
| 114 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.90386190 |
| 115 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.89976583 |
| 116 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.88995414 |
| 117 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.88473940 |
| 118 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.88092700 |
| 119 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.87286344 |
| 120 | * P68_20966046_ChIP-Seq_HELA_Human | 0.87027574 |
| 121 | RXR_22108803_ChIP-Seq_LS180_Human | 0.86915649 |
| 122 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.86682035 |
| 123 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.86460350 |
| 124 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.85556373 |
| 125 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.85355666 |
| 126 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.84751119 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.77646918 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 3.34565081 |
| 3 | MP0004270_analgesia | 2.99195923 |
| 4 | MP0003880_abnormal_central_pattern | 2.63022928 |
| 5 | MP0009780_abnormal_chondrocyte_physiolo | 2.61531701 |
| 6 | MP0004858_abnormal_nervous_system | 2.58010698 |
| 7 | MP0002063_abnormal_learning/memory/cond | 2.52963276 |
| 8 | MP0009745_abnormal_behavioral_response | 2.40930641 |
| 9 | MP0009046_muscle_twitch | 2.32854525 |
| 10 | MP0000751_myopathy | 2.30179567 |
| 11 | MP0005623_abnormal_meninges_morphology | 2.28625781 |
| 12 | MP0002064_seizures | 2.26455936 |
| 13 | MP0002909_abnormal_adrenal_gland | 2.13692831 |
| 14 | MP0003705_abnormal_hypodermis_morpholog | 2.05553077 |
| 15 | MP0005257_abnormal_intraocular_pressure | 2.01021782 |
| 16 | MP0000566_synostosis | 1.97396774 |
| 17 | MP0005423_abnormal_somatic_nervous | 1.93101466 |
| 18 | MP0001968_abnormal_touch/_nociception | 1.92853421 |
| 19 | MP0002734_abnormal_mechanical_nocicepti | 1.91913145 |
| 20 | MP0002822_catalepsy | 1.91725586 |
| 21 | MP0002572_abnormal_emotion/affect_behav | 1.90969810 |
| 22 | MP0005409_darkened_coat_color | 1.89440468 |
| 23 | MP0003329_amyloid_beta_deposits | 1.74041728 |
| 24 | MP0001486_abnormal_startle_reflex | 1.72729407 |
| 25 | MP0002272_abnormal_nervous_system | 1.72129875 |
| 26 | MP0010030_abnormal_orbit_morphology | 1.69651204 |
| 27 | MP0000013_abnormal_adipose_tissue | 1.68085441 |
| 28 | MP0002249_abnormal_larynx_morphology | 1.66833449 |
| 29 | MP0010368_abnormal_lymphatic_system | 1.65212322 |
| 30 | MP0000569_abnormal_digit_pigmentation | 1.63268586 |
| 31 | MP0008569_lethality_at_weaning | 1.62348720 |
| 32 | MP0004811_abnormal_neuron_physiology | 1.61750368 |
| 33 | MP0010234_abnormal_vibrissa_follicle | 1.57261899 |
| 34 | MP0004885_abnormal_endolymph | 1.55923829 |
| 35 | MP0008438_abnormal_cutaneous_collagen | 1.53147846 |
| 36 | MP0008961_abnormal_basal_metabolism | 1.52927449 |
| 37 | MP0004233_abnormal_muscle_weight | 1.52109466 |
| 38 | MP0002733_abnormal_thermal_nociception | 1.50878381 |
| 39 | MP0001501_abnormal_sleep_pattern | 1.49361790 |
| 40 | MP0002184_abnormal_innervation | 1.48712570 |
| 41 | MP0004145_abnormal_muscle_electrophysio | 1.45709583 |
| 42 | MP0000955_abnormal_spinal_cord | 1.45178802 |
| 43 | MP0000778_abnormal_nervous_system | 1.42741488 |
| 44 | MP0001440_abnormal_grooming_behavior | 1.41666111 |
| 45 | MP0001299_abnormal_eye_distance/ | 1.37459677 |
| 46 | MP0003122_maternal_imprinting | 1.33682156 |
| 47 | MP0001970_abnormal_pain_threshold | 1.33242154 |
| 48 | MP0003942_abnormal_urinary_system | 1.29885868 |
| 49 | MP0000579_abnormal_nail_morphology | 1.29110341 |
| 50 | MP0002837_dystrophic_cardiac_calcinosis | 1.28801553 |
| 51 | MP0003879_abnormal_hair_cell | 1.28705583 |
| 52 | MP0003566_abnormal_cell_adhesion | 1.27631770 |
| 53 | MP0002067_abnormal_sensory_capabilities | 1.27529788 |
| 54 | MP0002736_abnormal_nociception_after | 1.24574307 |
| 55 | MP0002557_abnormal_social/conspecific_i | 1.23598300 |
| 56 | MP0002735_abnormal_chemical_nociception | 1.21582060 |
| 57 | MP0004130_abnormal_muscle_cell | 1.20374739 |
| 58 | MP0002882_abnormal_neuron_morphology | 1.17861041 |
| 59 | MP0003045_fibrosis | 1.17222830 |
| 60 | MP0004272_abnormal_basement_membrane | 1.15522593 |
| 61 | MP0002234_abnormal_pharynx_morphology | 1.14744456 |
| 62 | MP0003633_abnormal_nervous_system | 1.12215978 |
| 63 | MP0002066_abnormal_motor_capabilities/c | 1.11026256 |
| 64 | MP0000747_muscle_weakness | 1.09249068 |
| 65 | MP0004924_abnormal_behavior | 1.07960128 |
| 66 | MP0005386_behavior/neurological_phenoty | 1.07960128 |
| 67 | MP0005167_abnormal_blood-brain_barrier | 1.06875355 |
| 68 | MP0000003_abnormal_adipose_tissue | 1.05572990 |
| 69 | MP0005508_abnormal_skeleton_morphology | 1.05140684 |
| 70 | MP0009384_cardiac_valve_regurgitation | 1.04533528 |
| 71 | MP0004084_abnormal_cardiac_muscle | 1.04086689 |
| 72 | MP0005275_abnormal_skin_tensile | 1.03923602 |
| 73 | MP0002152_abnormal_brain_morphology | 1.01990041 |
| 74 | MP0000428_abnormal_craniofacial_morphol | 0.99252472 |
| 75 | MP0003787_abnormal_imprinting | 0.98916269 |
| 76 | MP0001177_atelectasis | 0.98806050 |
| 77 | MP0004087_abnormal_muscle_fiber | 0.97853993 |
| 78 | MP0001958_emphysema | 0.96026806 |
| 79 | MP0003123_paternal_imprinting | 0.95137096 |
| 80 | MP0000920_abnormal_myelination | 0.94953160 |
| 81 | MP0005187_abnormal_penis_morphology | 0.94477635 |
| 82 | MP0002116_abnormal_craniofacial_bone | 0.94125405 |
| 83 | MP0004085_abnormal_heartbeat | 0.94123214 |
| 84 | MP0001348_abnormal_lacrimal_gland | 0.93814891 |
| 85 | MP0000767_abnormal_smooth_muscle | 0.92604986 |
| 86 | MP0000762_abnormal_tongue_morphology | 0.92159282 |
| 87 | MP0000537_abnormal_urethra_morphology | 0.91948545 |
| 88 | MP0003634_abnormal_glial_cell | 0.91275530 |
| 89 | MP0005171_absent_coat_pigmentation | 0.90661790 |
| 90 | MP0003631_nervous_system_phenotype | 0.89927333 |
| 91 | MP0003137_abnormal_impulse_conducting | 0.89318812 |
| 92 | MP0002089_abnormal_postnatal_growth/wei | 0.89196141 |
| 93 | MP0000462_abnormal_digestive_system | 0.88559905 |
| 94 | MP0002108_abnormal_muscle_morphology | 0.87996480 |
| 95 | MP0004215_abnormal_myocardial_fiber | 0.87451122 |
| 96 | MP0003075_altered_response_to | 0.86419571 |
| 97 | MP0002653_abnormal_ependyma_morphology | 0.85632871 |
| 98 | MP0004036_abnormal_muscle_relaxation | 0.85123373 |
| 99 | MP0002896_abnormal_bone_mineralization | 0.84636778 |
| 100 | MP0006138_congestive_heart_failure | 0.84581316 |
| 101 | MP0003385_abnormal_body_wall | 0.84457313 |
| 102 | MP0000678_abnormal_parathyroid_gland | 0.84210073 |
| 103 | MP0005503_abnormal_tendon_morphology | 0.83978235 |
| 104 | MP0003115_abnormal_respiratory_system | 0.83369081 |
| 105 | MP0000049_abnormal_middle_ear | 0.83292842 |
| 106 | MP0009053_abnormal_anal_canal | 0.83285911 |
| 107 | MP0002269_muscular_atrophy | 0.83166463 |
| 108 | * MP0000534_abnormal_ureter_morphology | 0.80787090 |
| 109 | MP0000759_abnormal_skeletal_muscle | 0.80636664 |
| 110 | MP0006276_abnormal_autonomic_nervous | 0.80594390 |
| 111 | MP0003091_abnormal_cell_migration | 0.80503374 |
| 112 | MP0003279_aneurysm | 0.79647169 |
| 113 | MP0001849_ear_inflammation | 0.79236838 |
| 114 | MP0001502_abnormal_circadian_rhythm | 0.77272633 |
| 115 | MP0009250_abnormal_appendicular_skeleto | 0.77033702 |
| 116 | MP0005620_abnormal_muscle_contractility | 0.76001169 |
| 117 | MP0002697_abnormal_eye_size | 0.75941800 |
| 118 | MP0003690_abnormal_glial_cell | 0.75621971 |
| 119 | MP0002932_abnormal_joint_morphology | 0.74728756 |
| 120 | MP0001879_abnormal_lymphatic_vessel | 0.74043283 |
| 121 | MP0002090_abnormal_vision | 0.74032092 |
| 122 | MP0005076_abnormal_cell_differentiation | 0.73837846 |
| 123 | MP0003632_abnormal_nervous_system | 0.72558497 |
| 124 | MP0005375_adipose_tissue_phenotype | 0.72378232 |
| 125 | MP0002069_abnormal_eating/drinking_beha | 0.71093602 |
| 126 | MP0001984_abnormal_olfaction | 0.68709158 |
| 127 | MP0000733_abnormal_muscle_development | 0.67934748 |
| 128 | MP0003861_abnormal_nervous_system | 0.67586447 |
| 129 | MP0002877_abnormal_melanocyte_morpholog | 0.66885858 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 4.36612456 |
| 2 | Focal motor seizures (HP:0011153) | 3.66364540 |
| 3 | Focal seizures (HP:0007359) | 3.58489478 |
| 4 | Visual hallucinations (HP:0002367) | 3.29369876 |
| 5 | Action tremor (HP:0002345) | 3.22402105 |
| 6 | Cerebral aneurysm (HP:0004944) | 3.02973260 |
| 7 | Abnormality of the lower motor neuron (HP:0002366) | 2.97571663 |
| 8 | Shallow orbits (HP:0000586) | 2.94168134 |
| 9 | Supranuclear gaze palsy (HP:0000605) | 2.83132645 |
| 10 | Ankle clonus (HP:0011448) | 2.78473797 |
| 11 | Insomnia (HP:0100785) | 2.77339940 |
| 12 | Neonatal short-limb short stature (HP:0008921) | 2.76417450 |
| 13 | Ulnar bowing (HP:0003031) | 2.73617344 |
| 14 | Hyperacusis (HP:0010780) | 2.65841990 |
| 15 | Upper limb amyotrophy (HP:0009129) | 2.60243565 |
| 16 | Distal upper limb amyotrophy (HP:0007149) | 2.60243565 |
| 17 | Vascular tortuosity (HP:0004948) | 2.58973517 |
| 18 | Protrusio acetabuli (HP:0003179) | 2.56076856 |
| 19 | Arterial tortuosity (HP:0005116) | 2.54481206 |
| 20 | Broad metatarsal (HP:0001783) | 2.48996907 |
| 21 | Pointed chin (HP:0000307) | 2.47724970 |
| 22 | Depression (HP:0000716) | 2.46926018 |
| 23 | Ventricular fibrillation (HP:0001663) | 2.42166557 |
| 24 | Hemiplegia (HP:0002301) | 2.42108773 |
| 25 | Bladder diverticulum (HP:0000015) | 2.37196405 |
| 26 | Progressive cerebellar ataxia (HP:0002073) | 2.35973688 |
| 27 | Lower limb amyotrophy (HP:0007210) | 2.35868835 |
| 28 | Mitral regurgitation (HP:0001653) | 2.32684139 |
| 29 | Bundle branch block (HP:0011710) | 2.31003989 |
| 30 | Bowel diverticulosis (HP:0005222) | 2.30006129 |
| 31 | Increased variability in muscle fiber diameter (HP:0003557) | 2.29829398 |
| 32 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.29295080 |
| 33 | Difficulty running (HP:0009046) | 2.29037327 |
| 34 | Abnormality of dentin (HP:0010299) | 2.28755711 |
| 35 | Fragile skin (HP:0001030) | 2.28713950 |
| 36 | Elfin facies (HP:0004428) | 2.27198072 |
| 37 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.26646666 |
| 38 | Postural instability (HP:0002172) | 2.24723697 |
| 39 | Dysmetric saccades (HP:0000641) | 2.24682492 |
| 40 | Torticollis (HP:0000473) | 2.22620254 |
| 41 | Atonic seizures (HP:0010819) | 2.20374903 |
| 42 | Neoplasm of the heart (HP:0100544) | 2.20024332 |
| 43 | Epileptic encephalopathy (HP:0200134) | 2.18221645 |
| 44 | Spinal rigidity (HP:0003306) | 2.17480566 |
| 45 | Papilledema (HP:0001085) | 2.17416872 |
| 46 | Dysdiadochokinesis (HP:0002075) | 2.16796868 |
| 47 | Abnormal social behavior (HP:0012433) | 2.16514800 |
| 48 | Impaired social interactions (HP:0000735) | 2.16514800 |
| 49 | Broad face (HP:0000283) | 2.16032070 |
| 50 | Generalized tonic-clonic seizures (HP:0002069) | 2.14871639 |
| 51 | Genetic anticipation (HP:0003743) | 2.14622290 |
| 52 | Poor eye contact (HP:0000817) | 2.12318664 |
| 53 | Hand muscle atrophy (HP:0009130) | 2.12238793 |
| 54 | Wormian bones (HP:0002645) | 2.12192976 |
| 55 | Premature rupture of membranes (HP:0001788) | 2.12164672 |
| 56 | Macroorchidism (HP:0000053) | 2.12100900 |
| 57 | Cerebral inclusion bodies (HP:0100314) | 2.11931535 |
| 58 | Bronchomalacia (HP:0002780) | 2.11121677 |
| 59 | Absence seizures (HP:0002121) | 2.10968817 |
| 60 | Wide anterior fontanel (HP:0000260) | 2.10831668 |
| 61 | Termporal pattern (HP:0011008) | 2.09785153 |
| 62 | Insidious onset (HP:0003587) | 2.09785153 |
| 63 | Megalencephaly (HP:0001355) | 2.09507514 |
| 64 | Hypoventilation (HP:0002791) | 2.09341626 |
| 65 | * Turricephaly (HP:0000262) | 2.09144659 |
| 66 | Coronal craniosynostosis (HP:0004440) | 2.08351089 |
| 67 | Renal duplication (HP:0000075) | 2.07725632 |
| 68 | Renovascular hypertension (HP:0100817) | 2.07026657 |
| 69 | Vertebral arch anomaly (HP:0008438) | 2.06076220 |
| 70 | Arnold-Chiari malformation (HP:0002308) | 2.02114517 |
| 71 | Urinary urgency (HP:0000012) | 2.02087253 |
| 72 | Ankle contracture (HP:0006466) | 2.01711608 |
| 73 | Aortic dissection (HP:0002647) | 2.00706351 |
| 74 | Mild short stature (HP:0003502) | 1.98785447 |
| 75 | Ankyloglossia (HP:0010296) | 1.98757880 |
| 76 | Enlarged penis (HP:0000040) | 1.97754746 |
| 77 | Rapidly progressive (HP:0003678) | 1.96965406 |
| 78 | Buphthalmos (HP:0000557) | 1.96748185 |
| 79 | Hypercortisolism (HP:0001578) | 1.96643723 |
| 80 | Annular pancreas (HP:0001734) | 1.96606094 |
| 81 | Disproportionate tall stature (HP:0001519) | 1.96087772 |
| 82 | Overriding aorta (HP:0002623) | 1.95556293 |
| 83 | Hyperextensible skin (HP:0000974) | 1.95531081 |
| 84 | Resting tremor (HP:0002322) | 1.95375293 |
| 85 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.94544058 |
| 86 | Achilles tendon contracture (HP:0001771) | 1.94130130 |
| 87 | Diplopia (HP:0000651) | 1.93364488 |
| 88 | Abnormality of binocular vision (HP:0011514) | 1.93364488 |
| 89 | Soft skin (HP:0000977) | 1.90432856 |
| 90 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.90287241 |
| 91 | Truncal ataxia (HP:0002078) | 1.88526374 |
| 92 | Mutism (HP:0002300) | 1.88052346 |
| 93 | Sudden death (HP:0001699) | 1.87745276 |
| 94 | Hyporeflexia of lower limbs (HP:0002600) | 1.85264104 |
| 95 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.84799786 |
| 96 | Flat cornea (HP:0007720) | 1.83882586 |
| 97 | Difficulty climbing stairs (HP:0003551) | 1.83850237 |
| 98 | Aortic aneurysm (HP:0004942) | 1.83160080 |
| 99 | Anxiety (HP:0000739) | 1.82675905 |
| 100 | Prolonged QT interval (HP:0001657) | 1.82031732 |
| 101 | Hemiparesis (HP:0001269) | 1.81862044 |
| 102 | Cervical subluxation (HP:0003308) | 1.81800733 |
| 103 | Febrile seizures (HP:0002373) | 1.81760665 |
| 104 | Focal dystonia (HP:0004373) | 1.81585859 |
| 105 | Dysmetria (HP:0001310) | 1.81415693 |
| 106 | Lower limb muscle weakness (HP:0007340) | 1.81026893 |
| 107 | Sleep apnea (HP:0010535) | 1.80701350 |
| 108 | Type 1 muscle fiber predominance (HP:0003803) | 1.80075969 |
| 109 | Dialeptic seizures (HP:0011146) | 1.80015420 |
| 110 | Thin ribs (HP:0000883) | 1.78305144 |
| 111 | Dilatation of the ascending aorta (HP:0005111) | 1.76617950 |
| 112 | Overgrowth (HP:0001548) | 1.76411646 |
| 113 | Increased connective tissue (HP:0009025) | 1.76232628 |
| 114 | Intention tremor (HP:0002080) | 1.75969718 |
| 115 | Abnormal eating behavior (HP:0100738) | 1.75351710 |
| 116 | Hammertoe (HP:0001765) | 1.75146320 |
| 117 | Lymphangioma (HP:0100764) | 1.75121072 |
| 118 | Impaired smooth pursuit (HP:0007772) | 1.74687562 |
| 119 | Hypoplasia of the iris (HP:0007676) | 1.74018997 |
| 120 | Mitral valve prolapse (HP:0001634) | 1.73921092 |
| 121 | Precocious puberty (HP:0000826) | 1.73825328 |
| 122 | Blue sclerae (HP:0000592) | 1.73707321 |
| 123 | Genu recurvatum (HP:0002816) | 1.73678469 |
| 124 | Obstructive sleep apnea (HP:0002870) | 1.73423169 |
| 125 | Neurofibrillary tangles (HP:0002185) | 1.72228798 |
| 126 | Biconcave vertebral bodies (HP:0004586) | 1.71055837 |
| 127 | Long toe (HP:0010511) | 1.70897273 |
| 128 | Aneurysm (HP:0002617) | 1.70593363 |
| 129 | Exercise-induced myalgia (HP:0003738) | 1.69375668 |
| 130 | Abnormality of the Achilles tendon (HP:0005109) | 1.69241727 |
| 131 | Atrophic scars (HP:0001075) | 1.69095314 |
| 132 | Joint laxity (HP:0001388) | 1.67814631 |
| 133 | Abnormality of the aortic arch (HP:0012303) | 1.65238869 |
| 134 | Vitreoretinal degeneration (HP:0000655) | 1.65196650 |
| 135 | Bowing of the arm (HP:0006488) | 1.64800955 |
| 136 | Bowed forearm bones (HP:0003956) | 1.64800955 |
| 137 | Megalocornea (HP:0000485) | 1.64172992 |
| 138 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.61661639 |
| 139 | Partial duplication of thumb phalanx (HP:0009944) | 1.60155658 |
| 140 | Patellar dislocation (HP:0002999) | 1.58689093 |
| 141 | Partial duplication of the phalanx of hand (HP:0009999) | 1.57783852 |
| 142 | Deviation of the hallux (HP:0010051) | 1.54278883 |
| 143 | Ectopia lentis (HP:0001083) | 1.52929897 |
| 144 | Akinesia (HP:0002304) | 1.52836853 |
| 145 | Tracheomalacia (HP:0002779) | 1.52796629 |
| 146 | Hypercalcemia (HP:0003072) | 1.52172377 |
| 147 | Long palpebral fissure (HP:0000637) | 1.51240659 |
| 148 | Morphological abnormality of the middle ear (HP:0008609) | 1.50416544 |
| 149 | Spastic gait (HP:0002064) | 1.49847461 |
| 150 | Choanal stenosis (HP:0000452) | 1.47826116 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.57312501 |
| 2 | MAP3K9 | 3.46339992 |
| 3 | EPHA4 | 2.94213431 |
| 4 | PRKD3 | 2.74414621 |
| 5 | TRIB3 | 2.73754693 |
| 6 | PAK6 | 2.41454323 |
| 7 | MARK1 | 2.34748389 |
| 8 | NTRK1 | 2.20909897 |
| 9 | RIPK1 | 2.18418601 |
| 10 | KSR2 | 2.16092211 |
| 11 | DAPK2 | 2.12745120 |
| 12 | MAP3K4 | 2.07049979 |
| 13 | MINK1 | 2.05940010 |
| 14 | CAMKK1 | 2.01158900 |
| 15 | LATS2 | 1.99322384 |
| 16 | NTRK2 | 1.79000666 |
| 17 | STK38 | 1.76918558 |
| 18 | DDR2 | 1.75587519 |
| 19 | PDGFRA | 1.71597337 |
| 20 | PKN2 | 1.70795418 |
| 21 | SMG1 | 1.66317875 |
| 22 | LMTK2 | 1.60433014 |
| 23 | TYRO3 | 1.58560728 |
| 24 | CDK12 | 1.58118191 |
| 25 | TTN | 1.46753142 |
| 26 | PHKG1 | 1.43795596 |
| 27 | PHKG2 | 1.43795596 |
| 28 | TAOK1 | 1.41335924 |
| 29 | CASK | 1.39828677 |
| 30 | ICK | 1.34641919 |
| 31 | CAMK1G | 1.32307240 |
| 32 | MAP2K4 | 1.29337928 |
| 33 | SIK2 | 1.29013091 |
| 34 | KSR1 | 1.26540708 |
| 35 | MAP3K2 | 1.26128156 |
| 36 | CDK5 | 1.24746735 |
| 37 | RET | 1.22971313 |
| 38 | ARAF | 1.19504984 |
| 39 | PRKCH | 1.17365795 |
| 40 | PAK3 | 1.15741159 |
| 41 | ALK | 1.14800574 |
| 42 | SCYL2 | 1.08939951 |
| 43 | BMX | 1.01050425 |
| 44 | FGFR4 | 1.00407466 |
| 45 | DMPK | 0.99250431 |
| 46 | FER | 0.98816521 |
| 47 | CDC42BPA | 0.94534596 |
| 48 | UHMK1 | 0.90558653 |
| 49 | NEK1 | 0.89700940 |
| 50 | STK11 | 0.89682624 |
| 51 | MARK2 | 0.89179980 |
| 52 | SIK1 | 0.85589056 |
| 53 | PTK2 | 0.85522734 |
| 54 | PTK6 | 0.83754463 |
| 55 | EEF2K | 0.83100859 |
| 56 | CAMK1D | 0.82704395 |
| 57 | WNK1 | 0.82033524 |
| 58 | DAPK1 | 0.79701622 |
| 59 | CAMKK2 | 0.74969913 |
| 60 | CDK15 | 0.74897477 |
| 61 | EPHB2 | 0.74843456 |
| 62 | MAP2K7 | 0.73722055 |
| 63 | CAMK2B | 0.73392846 |
| 64 | MAP3K10 | 0.73007196 |
| 65 | PNCK | 0.72672431 |
| 66 | MAP3K7 | 0.71589103 |
| 67 | PRKCG | 0.71538785 |
| 68 | MET | 0.70658702 |
| 69 | CDK18 | 0.70482090 |
| 70 | CAMK1 | 0.69782504 |
| 71 | GRK5 | 0.69114820 |
| 72 | SGK3 | 0.68774928 |
| 73 | CDK14 | 0.68441549 |
| 74 | PTK2B | 0.67145234 |
| 75 | MOS | 0.66077227 |
| 76 | MAP3K1 | 0.64706610 |
| 77 | CDK11A | 0.63442166 |
| 78 | ROCK1 | 0.62744307 |
| 79 | MAPK12 | 0.60692150 |
| 80 | PDGFRB | 0.60662342 |
| 81 | RPS6KA2 | 0.60523511 |
| 82 | FGFR2 | 0.59233085 |
| 83 | PLK2 | 0.58326603 |
| 84 | SGK223 | 0.57629145 |
| 85 | SGK494 | 0.57629145 |
| 86 | TESK1 | 0.57426944 |
| 87 | MTOR | 0.57333845 |
| 88 | MAP2K1 | 0.57317831 |
| 89 | TIE1 | 0.56947507 |
| 90 | PDPK1 | 0.56496529 |
| 91 | RIPK4 | 0.55749667 |
| 92 | SGK1 | 0.55238847 |
| 93 | PKN1 | 0.55101667 |
| 94 | CAMK2G | 0.54186432 |
| 95 | CAMK2A | 0.53721275 |
| 96 | PAK2 | 0.53391147 |
| 97 | RPS6KA3 | 0.52896087 |
| 98 | FGFR1 | 0.51453686 |
| 99 | PRKD1 | 0.50867888 |
| 100 | ERBB2 | 0.50566651 |
| 101 | LATS1 | 0.50432793 |
| 102 | PRKD2 | 0.50306199 |
| 103 | CAMK4 | 0.49034082 |
| 104 | ERN1 | 0.48688130 |
| 105 | PDK1 | 0.48143313 |
| 106 | MAPK13 | 0.47999480 |
| 107 | BRAF | 0.47543763 |
| 108 | MAPK10 | 0.46901073 |
| 109 | DAPK3 | 0.45207885 |
| 110 | DYRK1A | 0.45046240 |
| 111 | RPS6KL1 | 0.44991966 |
| 112 | RPS6KC1 | 0.44991966 |
| 113 | FYN | 0.44763582 |
| 114 | PINK1 | 0.44543774 |
| 115 | ROCK2 | 0.42375661 |
| 116 | FES | 0.41613461 |
| 117 | SGK2 | 0.41139203 |
| 118 | PRKCZ | 0.40955550 |
| 119 | PRPF4B | 0.40821024 |
| 120 | PRKAA1 | 0.40287250 |
| 121 | MAP3K13 | 0.40236213 |
| 122 | DYRK1B | 0.38328877 |
| 123 | TNIK | 0.37823995 |
| 124 | LIMK1 | 0.37763236 |
| 125 | MAPK8 | 0.34636569 |
| 126 | SRC | 0.34075974 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.39394700 |
| 2 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.27419908 |
| 3 | Nicotine addiction_Homo sapiens_hsa05033 | 2.17190057 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.10240595 |
| 5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.07593951 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 2.00362141 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.00153672 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.87393463 |
| 9 | Salivary secretion_Homo sapiens_hsa04970 | 1.78720474 |
| 10 | Insulin secretion_Homo sapiens_hsa04911 | 1.76910880 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.75347761 |
| 12 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.74785310 |
| 13 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.73654817 |
| 14 | Morphine addiction_Homo sapiens_hsa05032 | 1.73564592 |
| 15 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.73068639 |
| 16 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.72020877 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.65193667 |
| 18 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.61153384 |
| 19 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.59603304 |
| 20 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.56349957 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.47731559 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.44467551 |
| 23 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.43171279 |
| 24 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.43039846 |
| 25 | Cocaine addiction_Homo sapiens_hsa05030 | 1.42268947 |
| 26 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.40379262 |
| 27 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.39709636 |
| 28 | Glioma_Homo sapiens_hsa05214 | 1.38074612 |
| 29 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.37838541 |
| 30 | Gap junction_Homo sapiens_hsa04540 | 1.37559496 |
| 31 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.37556336 |
| 32 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.37071904 |
| 33 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.32349684 |
| 34 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.22278444 |
| 35 | Long-term depression_Homo sapiens_hsa04730 | 1.21695184 |
| 36 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.21108433 |
| 37 | Melanogenesis_Homo sapiens_hsa04916 | 1.20514725 |
| 38 | Taste transduction_Homo sapiens_hsa04742 | 1.19533472 |
| 39 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.19476501 |
| 40 | Axon guidance_Homo sapiens_hsa04360 | 1.18548375 |
| 41 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.16245298 |
| 42 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.16134187 |
| 43 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.14125390 |
| 44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.09476381 |
| 45 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.03271521 |
| 46 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.01923834 |
| 47 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.01868262 |
| 48 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.00307918 |
| 49 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.98948405 |
| 50 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.95755722 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.95467967 |
| 52 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.95237417 |
| 53 | Focal adhesion_Homo sapiens_hsa04510 | 0.92064067 |
| 54 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.91986232 |
| 55 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.90484754 |
| 56 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.90292143 |
| 57 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.87692452 |
| 58 | Endometrial cancer_Homo sapiens_hsa05213 | 0.87402905 |
| 59 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.83855721 |
| 60 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.81245324 |
| 61 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.81114724 |
| 62 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.80784360 |
| 63 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.79725112 |
| 64 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.79591994 |
| 65 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.79581915 |
| 66 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.79517808 |
| 67 | Bile secretion_Homo sapiens_hsa04976 | 0.79162678 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.77672507 |
| 69 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.76675557 |
| 70 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76535401 |
| 71 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.74679194 |
| 72 | Lysine degradation_Homo sapiens_hsa00310 | 0.73474479 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.71524685 |
| 74 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.69012595 |
| 75 | Amoebiasis_Homo sapiens_hsa05146 | 0.68906852 |
| 76 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.68828073 |
| 77 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.68778230 |
| 78 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.68727825 |
| 79 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.68330769 |
| 80 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.68075018 |
| 81 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.67855613 |
| 82 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.67630953 |
| 83 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.67512687 |
| 84 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.66673455 |
| 85 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.66179596 |
| 86 | Tight junction_Homo sapiens_hsa04530 | 0.65990566 |
| 87 | Endocytosis_Homo sapiens_hsa04144 | 0.64660094 |
| 88 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.63741062 |
| 89 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.62417787 |
| 90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62137298 |
| 91 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.61720534 |
| 92 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.60877098 |
| 93 | Bladder cancer_Homo sapiens_hsa05219 | 0.59775819 |
| 94 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.57865501 |
| 95 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.57686348 |
| 96 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.57665505 |
| 97 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.57394025 |
| 98 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.57100088 |
| 99 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.56771454 |
| 100 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.55804290 |
| 101 | Colorectal cancer_Homo sapiens_hsa05210 | 0.55496796 |
| 102 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.55178539 |
| 103 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.55178097 |
| 104 | Insulin resistance_Homo sapiens_hsa04931 | 0.54531796 |
| 105 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.54525261 |
| 106 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.53744492 |
| 107 | Adherens junction_Homo sapiens_hsa04520 | 0.51972116 |
| 108 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.51830242 |
| 109 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.51503293 |
| 110 | Prion diseases_Homo sapiens_hsa05020 | 0.51431588 |
| 111 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.50979066 |
| 112 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.50826216 |
| 113 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.50007719 |
| 114 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.49096642 |

