MEGF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.26204341
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.26204341
3modulation by symbiont of host immune response (GO:0052553)6.26204341
4positive regulation by symbiont of host defense response (GO:0052509)6.26204341
5modulation by symbiont of host defense response (GO:0052031)6.26204341
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.26204341
7detection of molecule of bacterial origin (GO:0032490)5.94575771
8positive regulation of gamma-delta T cell activation (GO:0046645)5.63607857
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.59267599
10negative regulation of cell killing (GO:0031342)5.59267599
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36536022
12macrophage activation involved in immune response (GO:0002281)5.33757862
13microglial cell activation (GO:0001774)5.05656432
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.99646582
15detection of other organism (GO:0098543)4.99357765
16cellular extravasation (GO:0045123)4.92241946
17detection of external biotic stimulus (GO:0098581)4.88526539
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.75207477
19neutrophil activation involved in immune response (GO:0002283)4.72527260
20regulation of interferon-beta biosynthetic process (GO:0045357)4.63662409
21regulation of B cell receptor signaling pathway (GO:0050855)4.57773870
22response to peptidoglycan (GO:0032494)4.53847407
23synaptic vesicle maturation (GO:0016188)4.53030359
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52884448
25locomotory exploration behavior (GO:0035641)4.51416919
26neuronal action potential propagation (GO:0019227)4.46392847
27vocalization behavior (GO:0071625)4.42887019
28macrophage activation (GO:0042116)4.41110312
29response to host immune response (GO:0052572)4.35130635
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.35130635
31detection of bacterium (GO:0016045)4.32289212
32detection of biotic stimulus (GO:0009595)4.27180436
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26990284
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25996367
35leukocyte migration involved in inflammatory response (GO:0002523)4.23747214
36neutrophil mediated immunity (GO:0002446)4.20736682
37synaptic vesicle exocytosis (GO:0016079)4.19541871
38positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.18676676
39glutamate secretion (GO:0014047)4.18275672
40neuron cell-cell adhesion (GO:0007158)4.16189160
41antigen processing and presentation of endogenous antigen (GO:0019883)4.14492144
42negative regulation of lymphocyte mediated immunity (GO:0002707)4.10946216
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10045185
44regulation of synaptic vesicle exocytosis (GO:2000300)4.07363473
45regulation of gamma-delta T cell activation (GO:0046643)4.07193162
46neutrophil activation (GO:0042119)4.03448662
47dendritic spine morphogenesis (GO:0060997)4.02287297
48leukocyte aggregation (GO:0070486)3.95839881
49response to host (GO:0075136)3.95612936
50response to host defenses (GO:0052200)3.95612936
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95612936
52negative regulation of interleukin-12 production (GO:0032695)3.94639028
53regulation of glutamate receptor signaling pathway (GO:1900449)3.87963573
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.87611476
55protein localization to synapse (GO:0035418)3.87358478
56response to interleukin-15 (GO:0070672)3.84066290
57neuron recognition (GO:0008038)3.72207186
58exploration behavior (GO:0035640)3.68442938
59production of molecular mediator involved in inflammatory response (GO:0002532)3.68168448
60layer formation in cerebral cortex (GO:0021819)3.63894697
61regulation of neuronal synaptic plasticity (GO:0048168)3.62402361
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62283487
63myeloid leukocyte mediated immunity (GO:0002444)3.60944881
64respiratory burst (GO:0045730)3.59819731
65myeloid cell activation involved in immune response (GO:0002275)3.57964730
66regulation of gamma-delta T cell differentiation (GO:0045586)3.57681127
67granulocyte activation (GO:0036230)3.56095296
68regulation of synaptic vesicle transport (GO:1902803)3.55030118
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.52910530
70axonal fasciculation (GO:0007413)3.52795557
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52191825
72cellular response to interleukin-15 (GO:0071350)3.51873444
73activated T cell proliferation (GO:0050798)3.50906185
74negative regulation of T cell mediated immunity (GO:0002710)3.49861613
75positive regulation of cellular amide metabolic process (GO:0034250)3.49495639
76neurotransmitter secretion (GO:0007269)3.48942107
77negative regulation of leukocyte mediated immunity (GO:0002704)3.48275568
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48096347
79glutamate receptor signaling pathway (GO:0007215)3.46973209
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.45950368
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.42446904
82positive regulation of mast cell activation (GO:0033005)3.40778550
83dendrite morphogenesis (GO:0048813)3.37118275
84synaptic transmission, glutamatergic (GO:0035249)3.36883625
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36731746
86regulation of mast cell degranulation (GO:0043304)3.35637568
87gamma-aminobutyric acid transport (GO:0015812)3.32225660
88neurotransmitter-gated ion channel clustering (GO:0072578)3.31993660
89antigen processing and presentation via MHC class Ib (GO:0002475)3.29650271
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27202448
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25104044
92negative regulation of B cell mediated immunity (GO:0002713)3.22686091
93negative regulation of immunoglobulin mediated immune response (GO:0002890)3.22686091
94neuron-neuron synaptic transmission (GO:0007270)3.22169079
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22145850
96cellular potassium ion homeostasis (GO:0030007)3.21701411
97regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21459451
98proline transport (GO:0015824)3.20000764
99regulation of synapse structural plasticity (GO:0051823)3.17527330
100auditory behavior (GO:0031223)3.16599975
101regulation of mast cell activation (GO:0033003)3.16426874
102regulation of mast cell activation involved in immune response (GO:0033006)3.15208268
103transmission of nerve impulse (GO:0019226)3.12246774
104B cell receptor signaling pathway (GO:0050853)3.10488537
105presynaptic membrane assembly (GO:0097105)3.09052510
106regulation of leukocyte degranulation (GO:0043300)3.08517014
107regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04982278
108innervation (GO:0060384)3.02196604
109regulation of macrophage cytokine production (GO:0010935)3.01310018
110regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00853687
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00089664
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99858263
113response to auditory stimulus (GO:0010996)2.99840086
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.99164265
115regulation of regulated secretory pathway (GO:1903305)2.97903004
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.94631748
117positive regulation of mast cell degranulation (GO:0043306)2.94631748
118regulation of beta-amyloid formation (GO:1902003)2.93527395
119cerebellar granule cell differentiation (GO:0021707)2.92580943
120regulation of postsynaptic membrane potential (GO:0060078)2.92463303
121long-term memory (GO:0007616)2.92147236
122neutrophil chemotaxis (GO:0030593)2.92077850
123dendritic cell migration (GO:0036336)2.91167572
124neurotransmitter transport (GO:0006836)2.91003956
125postsynaptic membrane organization (GO:0001941)2.90712225
126regulation of interleukin-8 biosynthetic process (GO:0045414)2.90566162
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90525560
128regulation of synaptic plasticity (GO:0048167)2.89457021
129dendritic spine organization (GO:0097061)2.88681499
130activation of protein kinase A activity (GO:0034199)2.88357248
131positive regulation of macrophage cytokine production (GO:0060907)2.88328854
132presynaptic membrane organization (GO:0097090)2.88125301
133regulation of vesicle fusion (GO:0031338)2.87698334
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86353299
135immunoglobulin mediated immune response (GO:0016064)2.86111803
136regulation of amyloid precursor protein catabolic process (GO:1902991)2.85769920
137regulation of dendritic spine morphogenesis (GO:0061001)2.85180099
138sodium ion export (GO:0071436)2.84860239
139neutrophil migration (GO:1990266)2.84858733
140mechanosensory behavior (GO:0007638)2.83777623
141negative regulation of type 2 immune response (GO:0002829)2.83732482
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83209309
143positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83017679
144regulation of cellular amide metabolic process (GO:0034248)2.82268928
145positive regulation of membrane potential (GO:0045838)2.81340413
146pyrimidine nucleobase catabolic process (GO:0006208)2.81197159
147long-term synaptic potentiation (GO:0060291)2.81020455
148cerebellar Purkinje cell differentiation (GO:0021702)2.80478926
149regulation of T-helper 2 cell differentiation (GO:0045628)2.79861072
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79613644
151negative regulation of T-helper cell differentiation (GO:0045623)2.79613644
152leukocyte degranulation (GO:0043299)2.79033570
153positive regulation of interferon-alpha production (GO:0032727)2.78858874
154nerve growth factor signaling pathway (GO:0038180)2.78180428
155negative regulation of erythrocyte differentiation (GO:0045647)2.77257376
156negative regulation of interleukin-17 production (GO:0032700)2.75765923
157response to muramyl dipeptide (GO:0032495)2.75741327
158regulation of synaptic transmission, glutamatergic (GO:0051966)2.75592821
159L-amino acid import (GO:0043092)2.75420086
160regulation of interleukin-6 biosynthetic process (GO:0045408)2.75254024
161synapse assembly (GO:0007416)2.74910353
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74570116
163myeloid leukocyte activation (GO:0002274)2.74029709
164cell migration in hindbrain (GO:0021535)2.73817251
165positive regulation of synapse maturation (GO:0090129)2.72528606
166central nervous system projection neuron axonogenesis (GO:0021952)2.69897308
167negative regulation of adaptive immune response (GO:0002820)2.69562770
168regulation of neurotransmitter levels (GO:0001505)2.69337061
169synaptic vesicle endocytosis (GO:0048488)2.68707812
170positive regulation of regulated secretory pathway (GO:1903307)2.68266338
171neuromuscular process controlling balance (GO:0050885)2.68133431
172regulation of neurotransmitter secretion (GO:0046928)2.67595359
173neuronal ion channel clustering (GO:0045161)2.67354042
174membrane depolarization during action potential (GO:0086010)2.66848533
175chemosensory behavior (GO:0007635)2.66002862
176vesicle transport along microtubule (GO:0047496)2.65699337
177detection of calcium ion (GO:0005513)2.65482959
178defense response to protozoan (GO:0042832)2.65353243
179positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.64758201
180positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64254367
181cell communication by electrical coupling (GO:0010644)2.63951046
182membrane depolarization (GO:0051899)2.62719127
183synapse organization (GO:0050808)2.62378363
184mating behavior (GO:0007617)2.59729653
185positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58258976
186cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.55299750
187positive regulation of synapse assembly (GO:0051965)2.54746821
188adult walking behavior (GO:0007628)2.54218785
189negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53666248
190learning (GO:0007612)2.52399673
191positive regulation of dendritic spine development (GO:0060999)2.52168284
192glycine transport (GO:0015816)2.51815089
193membrane hyperpolarization (GO:0060081)2.51459245
194organelle transport along microtubule (GO:0072384)2.51008835
195social behavior (GO:0035176)2.50567234
196intraspecies interaction between organisms (GO:0051703)2.50567234
197nucleobase catabolic process (GO:0046113)2.49288813
198regulation of dendritic spine development (GO:0060998)2.49210879
199axon ensheathment in central nervous system (GO:0032291)2.48234403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37752002
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.13580783
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88040008
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.66920280
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57637209
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.56887749
7GBX2_23144817_ChIP-Seq_PC3_Human3.45747915
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04049438
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99778039
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.97525603
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87004475
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84869556
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78293894
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69274440
15RUNX_20019798_ChIP-Seq_JUKART_Human2.60887327
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56415584
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52581718
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52581718
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45679115
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43544466
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42482006
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41938911
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40874265
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.38989252
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37796019
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34305120
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32563355
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.25855258
29SPI1_23127762_ChIP-Seq_K562_Human2.24947739
30REST_21632747_ChIP-Seq_MESCs_Mouse2.21387332
31DROSHA_22980978_ChIP-Seq_HELA_Human2.20190312
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14900335
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.14095707
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13767520
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08748463
36VDR_24787735_ChIP-Seq_THP-1_Human2.08399490
37RNF2_27304074_Chip-Seq_ESCs_Mouse2.08210158
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02198435
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95894127
40SPI1_23547873_ChIP-Seq_NB4_Human1.90474933
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.88865916
42SCL_19346495_ChIP-Seq_HPC-7_Human1.87296442
43AR_21572438_ChIP-Seq_LNCaP_Human1.85768444
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85237434
45TAF15_26573619_Chip-Seq_HEK293_Human1.81864545
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.78209522
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77561712
48VDR_24763502_ChIP-Seq_THP-1_Human1.75256820
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73540239
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67371089
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62523153
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61740263
53MYB_26560356_Chip-Seq_TH2_Human1.60489918
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59240950
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58628334
56SMAD4_21799915_ChIP-Seq_A2780_Human1.58439359
57IGF1R_20145208_ChIP-Seq_DFB_Human1.50912353
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50649581
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50370729
60* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49910827
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.47660774
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45970940
63P300_19829295_ChIP-Seq_ESCs_Human1.45835260
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.45129831
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45051423
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.43850610
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.43313818
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43311741
69ZNF274_21170338_ChIP-Seq_K562_Hela1.42675351
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42223411
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.40486278
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38609165
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38506632
74GATA3_27048872_Chip-Seq_THYMUS_Human1.37300843
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36732716
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35770859
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35727576
78* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34019369
79GATA1_22025678_ChIP-Seq_K562_Human1.33926310
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33369670
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33044829
82PU_27001747_Chip-Seq_BMDM_Mouse1.32657829
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.32423884
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.32339943
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32309404
86MYB_26560356_Chip-Seq_TH1_Human1.32284296
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.31551089
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.30907153
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30337965
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29924903
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29825515
92MAF_26560356_Chip-Seq_TH1_Human1.29416656
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28235062
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27876642
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27860674
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.27856459
97* STAT3_23295773_ChIP-Seq_U87_Human1.27672522
98AHR_22903824_ChIP-Seq_MCF-7_Human1.26786666
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.26343560
100AR_25329375_ChIP-Seq_VCAP_Human1.25893571
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23395273
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22313558
103TCF7_22412390_ChIP-Seq_EML_Mouse1.21833456
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21066723
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19741592
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19419548
107VDR_21846776_ChIP-Seq_THP-1_Human1.18713908
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17948426
109AR_19668381_ChIP-Seq_PC3_Human1.16424867
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16018783
111* GATA2_21666600_ChIP-Seq_HMVEC_Human1.14216377
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14096364
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.13804100
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13267903
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12931009
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12006403
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11820776
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11722129
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11287188
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10750557
121GATA3_26560356_Chip-Seq_TH2_Human1.09478797
122TP53_16413492_ChIP-PET_HCT116_Human1.08505132
123KDM2B_26808549_Chip-Seq_DND41_Human1.07805060
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07650713
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06753582
126UTX_26944678_Chip-Seq_JUKART_Human1.05743652
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05711203
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05444015
129* TCF4_23295773_ChIP-Seq_U87_Human1.03216329
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03013301
131RUNX2_22187159_ChIP-Seq_PCA_Human1.02676409
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02515610
133BCAT_22108803_ChIP-Seq_LS180_Human1.02504017
134* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02217223
135VDR_22108803_ChIP-Seq_LS180_Human1.02067419
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01898072
137RNF2_27304074_Chip-Seq_NSC_Mouse1.01516626
138* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01074484
139GATA2_19941826_ChIP-Seq_K562_Human0.99973943
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99941772
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99922642
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99095114
143* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99000214
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98123202
145* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98055422
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97973655
147* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97565006
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97464709
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96349091
150GATA1_19941826_ChIP-Seq_K562_Human0.95710264
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95575885
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95575885
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94297180
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93857880
155TP53_18474530_ChIP-ChIP_U2OS_Human0.92742085
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.92582431
157SMAD_19615063_ChIP-ChIP_OVARY_Human0.92129865
158* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91734241
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91683474
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91395394
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90922947
162DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90374874
163* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90310000
164KDM2B_26808549_Chip-Seq_K562_Human0.90165504
165GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90110378
166* PRDM14_20953172_ChIP-Seq_ESCs_Human0.89043687
167ER_23166858_ChIP-Seq_MCF-7_Human0.88448010
168CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88086484
169SMRT_27268052_Chip-Seq_Bcells_Human0.88011197
170KDM2B_26808549_Chip-Seq_JURKAT_Human0.87300774
171FOXO3_23340844_ChIP-Seq_DLD1_Human0.85596809
172CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83843829
173GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82282715
174LXR_22158963_ChIP-Seq_LIVER_Mouse0.81699378
175PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81060413
176FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80274698
177VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76731949
178GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75486068
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75090787
180CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69984484
181MAF_26560356_Chip-Seq_TH2_Human0.69170594
182NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.68542813
183STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.66907914
184STAT6_21828071_ChIP-Seq_BEAS2B_Human0.65838944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.48126507
2MP0003724_increased_susceptibility_to5.47894147
3MP0003880_abnormal_central_pattern4.32934362
4MP0004270_analgesia3.86406693
5MP0003635_abnormal_synaptic_transmissio3.66041279
6MP0003436_decreased_susceptibility_to3.57434508
7MP0003303_peritoneal_inflammation3.54020407
8MP0001835_abnormal_antigen_presentation3.39223680
9MP0002063_abnormal_learning/memory/cond3.00005660
10MP0002419_abnormal_innate_immunity2.88792951
11MP0009745_abnormal_behavioral_response2.79794359
12MP0002064_seizures2.74987683
13MP0001968_abnormal_touch/_nociception2.72977575
14MP0003191_abnormal_cellular_cholesterol2.58930025
15MP0002734_abnormal_mechanical_nocicepti2.57834384
16MP0009046_muscle_twitch2.57504437
17MP0005423_abnormal_somatic_nervous2.54635497
18MP0008260_abnormal_autophagy2.53240148
19MP0005025_abnormal_response_to2.46228093
20MP0002272_abnormal_nervous_system2.45164085
21MP0001800_abnormal_humoral_immune2.45017067
22MP0002572_abnormal_emotion/affect_behav2.44082624
23MP0009780_abnormal_chondrocyte_physiolo2.42815083
24MP0009785_altered_susceptibility_to2.42231139
25MP0000685_abnormal_immune_system2.41109997
26MP0001486_abnormal_startle_reflex2.40478918
27MP0003172_abnormal_lysosome_physiology2.36627794
28MP0006082_CNS_inflammation2.33509630
29MP0005000_abnormal_immune_tolerance2.32664034
30MP0003300_gastrointestinal_ulcer2.27208119
31MP0005671_abnormal_response_to2.24450596
32MP0002735_abnormal_chemical_nociception2.21551956
33MP0005387_immune_system_phenotype2.20613834
34MP0001790_abnormal_immune_system2.20613834
35MP0003329_amyloid_beta_deposits2.15080951
36MP0002723_abnormal_immune_serum2.14840305
37MP0000778_abnormal_nervous_system2.10145713
38MP0002733_abnormal_thermal_nociception2.08558542
39MP0004883_abnormal_blood_vessel2.08238341
40MP0002420_abnormal_adaptive_immunity2.06907392
41MP0004381_abnormal_hair_follicle2.05544642
42MP0001819_abnormal_immune_cell2.03614836
43MP0003828_pulmonary_edema2.03601902
44MP0002452_abnormal_antigen_presenting2.03522452
45MP0006276_abnormal_autonomic_nervous2.02489127
46MP0002067_abnormal_sensory_capabilities1.94032296
47MP0001440_abnormal_grooming_behavior1.91694163
48MP0002909_abnormal_adrenal_gland1.90922977
49MP0001501_abnormal_sleep_pattern1.90089177
50MP0002184_abnormal_innervation1.88155568
51MP0001533_abnormal_skeleton_physiology1.88011925
52MP0001970_abnormal_pain_threshold1.86247228
53MP0002736_abnormal_nociception_after1.85582865
54MP0004885_abnormal_endolymph1.81659346
55MP0008569_lethality_at_weaning1.78899096
56MP0004858_abnormal_nervous_system1.72815318
57MP0000465_gastrointestinal_hemorrhage1.71175182
58MP0002557_abnormal_social/conspecific_i1.65949778
59MP0005464_abnormal_platelet_physiology1.64362459
60MP0000015_abnormal_ear_pigmentation1.62592736
61MP0000955_abnormal_spinal_cord1.61171049
62MP0005645_abnormal_hypothalamus_physiol1.60215947
63MP0002148_abnormal_hypersensitivity_rea1.59053837
64MP0002277_abnormal_respiratory_mucosa1.57856291
65MP0002405_respiratory_system_inflammati1.55925208
66MP0004811_abnormal_neuron_physiology1.53827927
67MP0000920_abnormal_myelination1.53216738
68MP0005164_abnormal_response_to1.48024880
69MP0005646_abnormal_pituitary_gland1.47892471
70MP0000716_abnormal_immune_system1.47818915
71MP0002882_abnormal_neuron_morphology1.47006340
72MP0003075_altered_response_to1.46974290
73MP0001984_abnormal_olfaction1.46721282
74MP0001845_abnormal_inflammatory_respons1.46379842
75MP0003866_abnormal_defecation1.45643674
76MP0002132_abnormal_respiratory_system1.45027988
77MP0004924_abnormal_behavior1.45011650
78MP0005386_behavior/neurological_phenoty1.45011650
79MP0002837_dystrophic_cardiac_calcinosis1.43299414
80MP0002398_abnormal_bone_marrow1.42708017
81MP0003763_abnormal_thymus_physiology1.42034003
82MP0009764_decreased_sensitivity_to1.39067035
83MP0000013_abnormal_adipose_tissue1.38666459
84MP0005451_abnormal_body_composition1.38201437
85MP0003656_abnormal_erythrocyte_physiolo1.35959382
86MP0003633_abnormal_nervous_system1.35120735
87MP0002066_abnormal_motor_capabilities/c1.32789559
88MP0002166_altered_tumor_susceptibility1.32370457
89MP0004947_skin_inflammation1.30575991
90MP0001529_abnormal_vocalization1.29574684
91MP0003634_abnormal_glial_cell1.28297525
92MP0005174_abnormal_tail_pigmentation1.28081892
93MP0001851_eye_inflammation1.26858278
94MP0003122_maternal_imprinting1.26689670
95MP0004145_abnormal_muscle_electrophysio1.23419616
96MP0005075_abnormal_melanosome_morpholog1.20503348
97MP0003631_nervous_system_phenotype1.20381342
98MP0000689_abnormal_spleen_morphology1.19104511
99MP0002722_abnormal_immune_system1.18147627
100MP0005551_abnormal_eye_electrophysiolog1.18066925
101MP0008469_abnormal_protein_level1.17527303
102MP0001502_abnormal_circadian_rhythm1.17101342
103MP0001299_abnormal_eye_distance/1.16916004
104MP0009278_abnormal_bone_marrow1.15950659
105MP0010386_abnormal_urinary_bladder1.14432797
106MP0004742_abnormal_vestibular_system1.14385101
107MP0010155_abnormal_intestine_physiology1.13858052
108MP0002396_abnormal_hematopoietic_system1.12375211
109MP0001986_abnormal_taste_sensitivity1.10344067
110MP0002229_neurodegeneration1.09914127
111MP0002822_catalepsy1.09788202
112MP0003690_abnormal_glial_cell1.09246752
113MP0005397_hematopoietic_system_phenotyp1.07325050
114MP0001545_abnormal_hematopoietic_system1.07325050
115MP0003632_abnormal_nervous_system1.06712107
116MP0003283_abnormal_digestive_organ1.06652590
117MP0003879_abnormal_hair_cell1.05593665
118MP0002152_abnormal_brain_morphology1.05363232
119MP0002429_abnormal_blood_cell1.04150894
120MP0004142_abnormal_muscle_tone1.03247271
121MP0004484_altered_response_of1.02402306
122MP0000703_abnormal_thymus_morphology1.02031231
123MP0005310_abnormal_salivary_gland1.01625378
124MP0000858_altered_metastatic_potential1.01235888
125MP0005166_decreased_susceptibility_to0.99309215
126MP0002998_abnormal_bone_remodeling0.98779401
127MP0000604_amyloidosis0.96688251
128MP0008961_abnormal_basal_metabolism0.94481086
129MP0005535_abnormal_body_temperature0.92889848
130MP0003183_abnormal_peptide_metabolism0.92675932
131MP0000569_abnormal_digit_pigmentation0.92467139
132MP0005248_abnormal_Harderian_gland0.91996385
133MP0002069_abnormal_eating/drinking_beha0.90313117
134MP0000631_abnormal_neuroendocrine_gland0.87221277
135MP0002752_abnormal_somatic_nervous0.87085370
136MP0001963_abnormal_hearing_physiology0.87083565
137MP0001905_abnormal_dopamine_level0.85404616
138MP0005388_respiratory_system_phenotype0.84150524
139MP0002133_abnormal_respiratory_system0.84150524
140MP0003252_abnormal_bile_duct0.83756141
141MP0001188_hyperpigmentation0.83351259
142MP0000751_myopathy0.82428278
143MP0002638_abnormal_pupillary_reflex0.81906216
144MP0001177_atelectasis0.81233714
145MP0005253_abnormal_eye_physiology0.80896855
146MP0002928_abnormal_bile_duct0.80881010
147MP0004043_abnormal_pH_regulation0.80770475
148MP0002090_abnormal_vision0.80553230
149MP0001958_emphysema0.79225092
150MP0006072_abnormal_retinal_apoptosis0.78316215
151MP0002009_preneoplasia0.77182534
152MP0005187_abnormal_penis_morphology0.75944288
153MP0004510_myositis0.75909146
154MP0003787_abnormal_imprinting0.75076675
155MP0003221_abnormal_cardiomyocyte_apopto0.73668835
156MP0005058_abnormal_lysosome_morphology0.73454859
157MP0004085_abnormal_heartbeat0.73453029
158MP0001485_abnormal_pinna_reflex0.73289167
159MP0000579_abnormal_nail_morphology0.72617222
160MP0000371_diluted_coat_color0.72300394
161MP0002876_abnormal_thyroid_physiology0.68991965
162MP0002234_abnormal_pharynx_morphology0.68791530
163MP0005085_abnormal_gallbladder_physiolo0.67072200
164MP0003448_altered_tumor_morphology0.66374610
165MP0002006_tumorigenesis0.65985018
166MP0005409_darkened_coat_color0.64958502
167MP0002332_abnormal_exercise_endurance0.63947418
168MP0000249_abnormal_blood_vessel0.62992354
169MP0004130_abnormal_muscle_cell0.61459759
170MP0005171_absent_coat_pigmentation0.61326055
171MP0000026_abnormal_inner_ear0.60992337
172MP0009763_increased_sensitivity_to0.60775374
173MP0001943_abnormal_respiration0.60707795
174MP0000003_abnormal_adipose_tissue0.59294584
175MP0005394_taste/olfaction_phenotype0.59029255
176MP0005499_abnormal_olfactory_system0.59029255
177MP0001663_abnormal_digestive_system0.57799123
178MP0003195_calcinosis0.57570136
179MP0003861_abnormal_nervous_system0.56853671
180MP0000343_altered_response_to0.55706863
181MP0008874_decreased_physiological_sensi0.55254627
182MP0001944_abnormal_pancreas_morphology0.53759264
183MP0003045_fibrosis0.53474547

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.21700282
2Focal motor seizures (HP:0011153)5.84140989
3Recurrent bacterial skin infections (HP:0005406)5.81660327
4Recurrent abscess formation (HP:0002722)5.69918268
5Orchitis (HP:0100796)5.60415917
6Myositis (HP:0100614)5.51163467
7Optic neuritis (HP:0100653)5.48884121
8Retrobulbar optic neuritis (HP:0100654)5.48884121
9Recurrent gram-negative bacterial infections (HP:0005420)5.02504576
10Myokymia (HP:0002411)4.97885617
11Action tremor (HP:0002345)4.85507446
12Abnormality of macrophages (HP:0004311)4.64911610
13Focal seizures (HP:0007359)4.41919410
14Termporal pattern (HP:0011008)4.41082125
15Insidious onset (HP:0003587)4.41082125
16Stomatitis (HP:0010280)4.17346202
17Gastrointestinal infarctions (HP:0005244)4.05963604
18Keratoconjunctivitis sicca (HP:0001097)4.04153660
19Recurrent skin infections (HP:0001581)4.00737319
20Recurrent fungal infections (HP:0002841)3.95882629
21Epileptic encephalopathy (HP:0200134)3.93485191
22Supranuclear gaze palsy (HP:0000605)3.78483422
23Elevated erythrocyte sedimentation rate (HP:0003565)3.73637330
24Visual hallucinations (HP:0002367)3.73142778
25Keratoconjunctivitis (HP:0001096)3.72962652
26Chronic mucocutaneous candidiasis (HP:0002728)3.67739185
27Recurrent cutaneous fungal infections (HP:0011370)3.67739185
28Hypochromic microcytic anemia (HP:0004840)3.63260359
29Atonic seizures (HP:0010819)3.58315358
30Progressive cerebellar ataxia (HP:0002073)3.58225354
31Ulnar claw (HP:0001178)3.57875069
32Neurofibrillary tangles (HP:0002185)3.56486160
33Gingivitis (HP:0000230)3.53148901
34Gingival bleeding (HP:0000225)3.43067280
35Meningitis (HP:0001287)3.35510066
36Febrile seizures (HP:0002373)3.35036531
37Mediastinal lymphadenopathy (HP:0100721)3.34122055
38Spontaneous hematomas (HP:0007420)3.30692176
39Encephalitis (HP:0002383)3.29686780
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.28748287
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.26640770
42Peritonitis (HP:0002586)3.24186095
43Hyperventilation (HP:0002883)3.23083426
44Absence seizures (HP:0002121)3.21910176
45Cerebral inclusion bodies (HP:0100314)3.21651678
46Chronic obstructive pulmonary disease (HP:0006510)3.17393285
47Obstructive lung disease (HP:0006536)3.17393285
48Generalized tonic-clonic seizures (HP:0002069)3.16914360
49Urticaria (HP:0001025)3.11497591
50Hemoptysis (HP:0002105)3.08289905
51Poor eye contact (HP:0000817)3.05793350
52T lymphocytopenia (HP:0005403)3.05602354
53Amyloidosis (HP:0011034)3.03654866
54Arterial thrombosis (HP:0004420)3.01355631
55Broad-based gait (HP:0002136)2.98770248
56Excessive salivation (HP:0003781)2.98380072
57Drooling (HP:0002307)2.98380072
58Abnormality of T cell number (HP:0011839)2.97532869
59Vasculitis (HP:0002633)2.94688097
60Papilledema (HP:0001085)2.94553525
61Dialeptic seizures (HP:0011146)2.94228263
62Pulmonary embolism (HP:0002204)2.90158225
63Episodic fever (HP:0001954)2.89924104
64Chest pain (HP:0100749)2.87900514
65Hypochromic anemia (HP:0001931)2.85971113
66Amblyopia (HP:0000646)2.85926054
67Impaired social interactions (HP:0000735)2.84050383
68Abnormal social behavior (HP:0012433)2.84050383
69Truncal ataxia (HP:0002078)2.82237647
70Prolonged bleeding time (HP:0003010)2.80449514
71Dysdiadochokinesis (HP:0002075)2.79223516
72Pulmonary infiltrates (HP:0002113)2.78939544
73Dysmetria (HP:0001310)2.77870859
74Intention tremor (HP:0002080)2.76140833
75Epileptiform EEG discharges (HP:0011182)2.74690968
76Ankle clonus (HP:0011448)2.72534959
77Depression (HP:0000716)2.70007029
78Megalencephaly (HP:0001355)2.69186643
79EEG with generalized epileptiform discharges (HP:0011198)2.67226521
80Subacute progressive viral hepatitis (HP:0006572)2.65646216
81Increased IgE level (HP:0003212)2.65491212
82Pheochromocytoma (HP:0002666)2.64886539
83Leukocytosis (HP:0001974)2.60953786
84Abnormal eating behavior (HP:0100738)2.60322832
85Hemiparesis (HP:0001269)2.59386193
86Cellulitis (HP:0100658)2.59362225
87Hypsarrhythmia (HP:0002521)2.57082015
88Abnormality of the corticospinal tract (HP:0002492)2.51278945
89Anorexia (HP:0002039)2.51029505
90Gangrene (HP:0100758)2.49989724
91Peripheral hypomyelination (HP:0007182)2.48985375
92Spastic gait (HP:0002064)2.48654013
93Agitation (HP:0000713)2.48322633
94Gaze-evoked nystagmus (HP:0000640)2.46448826
95Epistaxis (HP:0000421)2.45848788
96Anxiety (HP:0000739)2.45493003
97Absent speech (HP:0001344)2.45374708
98Scanning speech (HP:0002168)2.42205295
99Impaired vibration sensation in the lower limbs (HP:0002166)2.41227854
100Abnormality of the endocardium (HP:0004306)2.40315092
101Segmental peripheral demyelination/remyelination (HP:0003481)2.35525807
102Slow saccadic eye movements (HP:0000514)2.32659838
103Postural tremor (HP:0002174)2.31844914
104Onion bulb formation (HP:0003383)2.31433820
105Cheilitis (HP:0100825)2.30168257
106Urinary urgency (HP:0000012)2.27083253
107Urinary bladder sphincter dysfunction (HP:0002839)2.23793879
108Osteomyelitis (HP:0002754)2.23596356
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22924241
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18648715
111Macroorchidism (HP:0000053)2.18608996
112Vertigo (HP:0002321)2.17810926
113Microcytic anemia (HP:0001935)2.17808481
114Blue irides (HP:0000635)2.17361729
115Difficulty running (HP:0009046)2.15623247
116Neuroendocrine neoplasm (HP:0100634)2.14763274
117Polyphagia (HP:0002591)2.14586257
118Hammertoe (HP:0001765)2.13440619
119Exotropia (HP:0000577)2.12494258
120Abnormality of the pleura (HP:0002103)2.11387458
121Lower limb muscle weakness (HP:0007340)2.09114450
122Sepsis (HP:0100806)2.08567025
123Progressive inability to walk (HP:0002505)2.07573189
124Acne (HP:0001061)2.04258600
125Mutism (HP:0002300)2.02301480
126Abnormality of T cells (HP:0002843)2.01839265
127Degeneration of the lateral corticospinal tracts (HP:0002314)2.01394033
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01394033
129Abnormality of salivation (HP:0100755)2.01307150
130Impaired smooth pursuit (HP:0007772)2.00531274
131Recurrent viral infections (HP:0004429)2.00413063
132Abnormality of the peritoneum (HP:0002585)1.99838964
133Limb dystonia (HP:0002451)1.98905667
134Genetic anticipation (HP:0003743)1.98392791
135Hemiplegia (HP:0002301)1.98295637
136Gait ataxia (HP:0002066)1.97919880
137Viral hepatitis (HP:0006562)1.97055917
138Insomnia (HP:0100785)1.96649548
139Abnormality of binocular vision (HP:0011514)1.95225762
140Diplopia (HP:0000651)1.95225762
141Abnormality of the lower motor neuron (HP:0002366)1.93737302
142Torticollis (HP:0000473)1.93655618
143Ocular albinism (HP:0001107)1.93575523
144Keratitis (HP:0000491)1.92992208
145Stereotypic behavior (HP:0000733)1.92278234
146Postural instability (HP:0002172)1.91536844
147Abnormal platelet volume (HP:0011876)1.90525027
148Granulocytopenia (HP:0001913)1.89041676
149Retinal dysplasia (HP:0007973)1.88155682
150Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87938020
151Akinesia (HP:0002304)1.86893758
152Focal dystonia (HP:0004373)1.86736421
153Periodontitis (HP:0000704)1.85117967
154Steppage gait (HP:0003376)1.84913371
155Eosinophilia (HP:0001880)1.83902828
156Failure to thrive in infancy (HP:0001531)1.83472487
157Inflammation of the large intestine (HP:0002037)1.83441295
158Glomerulopathy (HP:0100820)1.81546860
159Increased CSF protein (HP:0002922)1.81364949
160Resting tremor (HP:0002322)1.80316102
161Abnormality of calcium-phosphate metabolism (HP:0100530)1.78588747
162Papillary thyroid carcinoma (HP:0002895)1.78199722
163Status epilepticus (HP:0002133)1.78164151
164Aqueductal stenosis (HP:0002410)1.77836234
165Clonus (HP:0002169)1.77058658
166Decreased motor nerve conduction velocity (HP:0003431)1.76746359
167Acute hepatic failure (HP:0006554)1.76591857
168Thickened helices (HP:0000391)1.75622713
169Aplasia involving bones of the extremities (HP:0009825)1.74351756
170Aplasia involving bones of the upper limbs (HP:0009823)1.74351756
171Aplasia of the phalanges of the hand (HP:0009802)1.74351756
172Inability to walk (HP:0002540)1.74187896
173Bradykinesia (HP:0002067)1.73876437
174Thrombophlebitis (HP:0004418)1.73813702
175Spastic tetraplegia (HP:0002510)1.73456346
176Polycythemia (HP:0001901)1.72717822
177Abnormality of glycosphingolipid metabolism (HP:0004343)1.72201124
178Abnormality of glycolipid metabolism (HP:0010969)1.72201124
179Abnormality of liposaccharide metabolism (HP:0010968)1.72201124
180Hypoplasia of the brainstem (HP:0002365)1.71609654
181Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71609654
182Gastrointestinal inflammation (HP:0004386)1.71254679
183Increased cerebral lipofuscin (HP:0011813)1.70062761
184Loss of speech (HP:0002371)1.69738139
185Ventricular fibrillation (HP:0001663)1.68638163
186Abnormality of the pericardium (HP:0001697)1.68538617
187Joint swelling (HP:0001386)1.68137769
188Skin ulcer (HP:0200042)1.65379131
189Hypergammaglobulinemia (HP:0010702)1.64765708
190Interstitial pulmonary disease (HP:0006530)1.63182999
191Paresthesia (HP:0003401)1.62214792
192Skin rash (HP:0000988)1.60328627
193Memory impairment (HP:0002354)1.60221538
194Increased IgM level (HP:0003496)1.60037672
195Abnormality of eosinophils (HP:0001879)1.58621002
196Pustule (HP:0200039)1.58308537
197Chronic otitis media (HP:0000389)1.57988623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.94149602
2MAP3K93.65903051
3MARK13.33532178
4BLK3.22850315
5EPHA43.07239761
6MAP2K32.81809852
7IRAK42.68995482
8TYK22.64203442
9MAP3K42.53960735
10MINK12.51953489
11CSK2.51622804
12UHMK12.22991829
13NTRK12.20242904
14PRPF4B2.16313475
15CASK2.08450608
16MAP4K12.06998109
17EPHB12.02295847
18PAK62.02057730
19NTRK21.99570858
20KSR11.94731346
21GRK61.92146495
22DAPK21.91225824
23MAP2K71.89038571
24YES11.89001244
25PRKD31.86915953
26SIK31.85431379
27ERN11.76625432
28ZAP701.67614544
29BCR1.66943528
30KSR21.66901180
31TAOK11.62437272
32TNK21.60108235
33MAP2K41.58805451
34JAK21.58089819
35TXK1.57179216
36CDK51.56971781
37MAP3K31.56912534
38TAOK31.52871034
39HCK1.51856700
40SYK1.46687781
41JAK11.42706162
42CAMKK11.37879341
43JAK31.36907202
44INSRR1.36724961
45RIPK41.34429253
46MAPK131.33077284
47MAP3K121.32235648
48STK391.28962639
49MAP3K21.28608375
50BTK1.28583106
51MAP3K61.27658550
52IKBKE1.27180136
53SIK21.26505765
54MAP3K141.23669234
55OXSR11.23630319
56FGFR21.22608226
57PNCK1.17409799
58LYN1.15098918
59TNIK1.14435627
60TYRO31.13923490
61PLK21.13753116
62FGFR31.13254341
63PAK31.08776425
64DAPK11.05714086
65MAP3K131.02245084
66PHKG21.01496953
67PHKG11.01496953
68SGK2231.01370355
69SGK4941.01370355
70GRK51.01097365
71PRKCG1.00793497
72RET0.99724828
73WNK30.98358218
74FER0.97506177
75CAMK2A0.97077736
76CDK190.96069615
77RAF10.95952543
78CAMK1G0.93111152
79CAMK2B0.92483623
80MAP3K110.91624407
81CSF1R0.90849524
82EPHA30.88939393
83CAMKK20.88364054
84LRRK20.87791239
85CDK180.86321662
86LCK0.85820516
87IRAK20.85794367
88PIK3CG0.83467539
89WNK40.83351507
90MARK30.81887073
91CDK140.81788826
92PRKCH0.80665368
93MARK20.79465303
94ITK0.78321865
95WNK10.78239299
96PTK60.76776613
97CDK150.76429968
98TGFBR20.75893399
99STK110.73211384
100FES0.72719296
101TEC0.72496229
102CSNK1G20.71973407
103MAPK120.71691308
104MATK0.70435440
105DYRK1A0.69708691
106KIT0.69360207
107FGR0.69296401
108ERBB30.68803690
109TBK10.67701455
110STK380.66355591
111PRKCE0.66155292
112SGK10.63958628
113CDK11A0.63194298
114MAP3K70.63127307
115CAMK2D0.62244671
116PRKD20.60267899
117IRAK10.60083168
118MAP3K50.59450420
119PKN10.59380306
120BMPR20.58689940
121SGK20.58632918
122MAP3K10.57241410
123PDGFRA0.57214498
124CAMK40.55907120
125PTK2B0.55895645
126FYN0.55416684
127PRKCZ0.53543468
128STK100.51810046
129ROCK20.51210405
130MAP2K60.50610849
131DYRK20.50218739
132PDPK10.50154463
133EPHB20.49546025
134MAPK70.49126421
135DYRK1B0.48785129
136NEK60.48662420
137DMPK0.48588392
138ICK0.47997807
139CAMK10.46386775
140SGK30.45822361
141PDK10.45431264
142RPS6KA30.45355691
143LMTK20.45201445
144PDGFRB0.44729239
145PRKD10.43051633
146CDC42BPA0.42464343
147FGFR40.42272993
148LATS20.41700532
149CAMK2G0.41643010
150MAPK100.41442594
151HIPK20.40471336
152PTK20.39747032
153PRKCQ0.39520970
154MAP2K10.39465090
155NLK0.39258811
156FRK0.38789640
157PRKG10.35243729
158PRKCB0.34863666
159ERBB20.32824652
160RIPK10.31316547

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01359544
2Osteoclast differentiation_Homo sapiens_hsa043802.70738286
3Leishmaniasis_Homo sapiens_hsa051402.59542670
4Staphylococcus aureus infection_Homo sapiens_hsa051502.42856834
5GABAergic synapse_Homo sapiens_hsa047272.42439789
6Synaptic vesicle cycle_Homo sapiens_hsa047212.40094188
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36795881
8Glutamatergic synapse_Homo sapiens_hsa047242.34512685
9Circadian entrainment_Homo sapiens_hsa047132.33653005
10Long-term potentiation_Homo sapiens_hsa047202.29795275
11Morphine addiction_Homo sapiens_hsa050322.11797271
12B cell receptor signaling pathway_Homo sapiens_hsa046622.06205795
13Insulin secretion_Homo sapiens_hsa049112.06007485
14Olfactory transduction_Homo sapiens_hsa047402.05236438
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04998035
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01730085
17Amphetamine addiction_Homo sapiens_hsa050312.01711307
18Tuberculosis_Homo sapiens_hsa051522.00666949
19Dopaminergic synapse_Homo sapiens_hsa047281.98571380
20Salivary secretion_Homo sapiens_hsa049701.86988814
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86533378
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83330797
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83148873
24Cholinergic synapse_Homo sapiens_hsa047251.73554795
25Taste transduction_Homo sapiens_hsa047421.68707249
26Gastric acid secretion_Homo sapiens_hsa049711.65179337
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63976329
28Renin secretion_Homo sapiens_hsa049241.63937902
29Serotonergic synapse_Homo sapiens_hsa047261.62874115
30Chemokine signaling pathway_Homo sapiens_hsa040621.60888493
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57364839
32Malaria_Homo sapiens_hsa051441.56894709
33Long-term depression_Homo sapiens_hsa047301.56843815
34Acute myeloid leukemia_Homo sapiens_hsa052211.48029652
35T cell receptor signaling pathway_Homo sapiens_hsa046601.47274824
36Cocaine addiction_Homo sapiens_hsa050301.46396892
37Measles_Homo sapiens_hsa051621.44292008
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44229877
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44193256
40Nitrogen metabolism_Homo sapiens_hsa009101.41071625
41Axon guidance_Homo sapiens_hsa043601.40675222
42Oxytocin signaling pathway_Homo sapiens_hsa049211.35739324
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33689525
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32262899
45Legionellosis_Homo sapiens_hsa051341.31925607
46Type II diabetes mellitus_Homo sapiens_hsa049301.31029593
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27509657
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.26903949
49GnRH signaling pathway_Homo sapiens_hsa049121.26866863
50Phagosome_Homo sapiens_hsa041451.25620656
51Platelet activation_Homo sapiens_hsa046111.23903966
52Gap junction_Homo sapiens_hsa045401.23238256
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22869409
54Calcium signaling pathway_Homo sapiens_hsa040201.21764160
55Phototransduction_Homo sapiens_hsa047441.20286325
56Toxoplasmosis_Homo sapiens_hsa051451.20251971
57Prolactin signaling pathway_Homo sapiens_hsa049171.17047980
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15746608
59Estrogen signaling pathway_Homo sapiens_hsa049151.14184731
60Graft-versus-host disease_Homo sapiens_hsa053321.12457691
61cAMP signaling pathway_Homo sapiens_hsa040241.12155294
62Influenza A_Homo sapiens_hsa051641.11637937
63Glioma_Homo sapiens_hsa052141.11235793
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.11061838
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10058008
66Hematopoietic cell lineage_Homo sapiens_hsa046401.09254112
67Dorso-ventral axis formation_Homo sapiens_hsa043201.09205073
68ErbB signaling pathway_Homo sapiens_hsa040121.06988509
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06807979
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05826905
71Hepatitis B_Homo sapiens_hsa051611.04973201
72African trypanosomiasis_Homo sapiens_hsa051431.03862005
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03035524
74Allograft rejection_Homo sapiens_hsa053301.02730306
75Melanogenesis_Homo sapiens_hsa049161.01743887
76Collecting duct acid secretion_Homo sapiens_hsa049660.99716428
77Pancreatic cancer_Homo sapiens_hsa052120.99123929
78Chronic myeloid leukemia_Homo sapiens_hsa052200.99003739
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98013047
80Autoimmune thyroid disease_Homo sapiens_hsa053200.97002393
81TNF signaling pathway_Homo sapiens_hsa046680.96232220
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95248600
83FoxO signaling pathway_Homo sapiens_hsa040680.94517443
84Pancreatic secretion_Homo sapiens_hsa049720.93278062
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.92461038
86Hepatitis C_Homo sapiens_hsa051600.92362134
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91884091
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87251046
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86366317
90Pertussis_Homo sapiens_hsa051330.85174751
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.85109347
92Vibrio cholerae infection_Homo sapiens_hsa051100.84934065
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81977844
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81974215
95Butanoate metabolism_Homo sapiens_hsa006500.80085051
96Thyroid hormone synthesis_Homo sapiens_hsa049180.78286770
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.78232403
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.77706425
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76915948
100Salmonella infection_Homo sapiens_hsa051320.70963353
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70854795
102Primary immunodeficiency_Homo sapiens_hsa053400.69952083
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69168038
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.67535920
105VEGF signaling pathway_Homo sapiens_hsa043700.66991933
106Choline metabolism in cancer_Homo sapiens_hsa052310.66972528
107Glucagon signaling pathway_Homo sapiens_hsa049220.66556826
108Amoebiasis_Homo sapiens_hsa051460.65680252
109Ras signaling pathway_Homo sapiens_hsa040140.65640358
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64363632
111Apoptosis_Homo sapiens_hsa042100.64330281
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63557941
113Insulin resistance_Homo sapiens_hsa049310.63178574
114Antigen processing and presentation_Homo sapiens_hsa046120.62705787
115Notch signaling pathway_Homo sapiens_hsa043300.62626833
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62609782
117Complement and coagulation cascades_Homo sapiens_hsa046100.62127221
118Dilated cardiomyopathy_Homo sapiens_hsa054140.62112551
119Prion diseases_Homo sapiens_hsa050200.61870853
120Renal cell carcinoma_Homo sapiens_hsa052110.61797370
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.60424384
122Bile secretion_Homo sapiens_hsa049760.59872925
123Viral myocarditis_Homo sapiens_hsa054160.59711211
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.59523688
125MAPK signaling pathway_Homo sapiens_hsa040100.59167026
126Herpes simplex infection_Homo sapiens_hsa051680.57221601
127Lysosome_Homo sapiens_hsa041420.57205688
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56429223
129Regulation of autophagy_Homo sapiens_hsa041400.56016229
130HIF-1 signaling pathway_Homo sapiens_hsa040660.55515836
131Cardiac muscle contraction_Homo sapiens_hsa042600.54416234
132Colorectal cancer_Homo sapiens_hsa052100.53800920
133Endometrial cancer_Homo sapiens_hsa052130.53648017
134Shigellosis_Homo sapiens_hsa051310.53546493
135Oocyte meiosis_Homo sapiens_hsa041140.52077160
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51131714
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50864248
138Inositol phosphate metabolism_Homo sapiens_hsa005620.49619044
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49371189
140Rap1 signaling pathway_Homo sapiens_hsa040150.47974776
141Insulin signaling pathway_Homo sapiens_hsa049100.45915430
142Alcoholism_Homo sapiens_hsa050340.45686814
143Wnt signaling pathway_Homo sapiens_hsa043100.45198286
144Endocytosis_Homo sapiens_hsa041440.43551240
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43540261
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42815719
147Ovarian steroidogenesis_Homo sapiens_hsa049130.41681238
148Circadian rhythm_Homo sapiens_hsa047100.41494434
149Ether lipid metabolism_Homo sapiens_hsa005650.40334202
150Sulfur metabolism_Homo sapiens_hsa009200.40096317
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38312381
152Fatty acid elongation_Homo sapiens_hsa000620.38285596
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37269511
154mTOR signaling pathway_Homo sapiens_hsa041500.36441870
155Type I diabetes mellitus_Homo sapiens_hsa049400.36042536
156Fatty acid biosynthesis_Homo sapiens_hsa000610.35328187
157Hedgehog signaling pathway_Homo sapiens_hsa043400.34994005
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33219156
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.32888508
160Non-small cell lung cancer_Homo sapiens_hsa052230.31621481

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