MEI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.26089746
2synaptonemal complex assembly (GO:0007130)7.36938687
3synaptonemal complex organization (GO:0070193)7.01285897
4regulation of meiosis I (GO:0060631)6.96236158
5DNA methylation involved in gamete generation (GO:0043046)6.82822255
6male meiosis (GO:0007140)6.48201189
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.68983423
8positive regulation of gamma-delta T cell activation (GO:0046645)5.43321470
9regulation of B cell receptor signaling pathway (GO:0050855)5.29596320
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07133140
11negative regulation of cell killing (GO:0031342)4.99700467
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99700467
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.96843131
14* meiotic nuclear division (GO:0007126)4.90499620
15chromosome organization involved in meiosis (GO:0070192)4.83355268
16* male meiosis I (GO:0007141)4.76481062
17cellular response to interleukin-15 (GO:0071350)4.70847571
18T cell migration (GO:0072678)4.67831301
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53009273
20* meiosis I (GO:0007127)4.45809751
21response to interleukin-15 (GO:0070672)4.41280199
22negative regulation of meiosis (GO:0045835)4.33715529
23cytidine deamination (GO:0009972)4.29673381
24cytidine metabolic process (GO:0046087)4.29673381
25cytidine catabolic process (GO:0006216)4.29673381
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24588258
27negative T cell selection (GO:0043383)4.18656868
28negative thymic T cell selection (GO:0045060)4.14009896
29regulation of gamma-delta T cell activation (GO:0046643)4.13927034
30leukocyte aggregation (GO:0070486)4.05956834
31antigen processing and presentation of endogenous antigen (GO:0019883)4.05321143
32pyrimidine ribonucleoside catabolic process (GO:0046133)4.02133216
33tolerance induction (GO:0002507)3.98396941
34glutamate secretion (GO:0014047)3.97394308
35oocyte maturation (GO:0001556)3.94777698
36regulation of gamma-delta T cell differentiation (GO:0045586)3.94345943
37positive regulation of neurotransmitter secretion (GO:0001956)3.90646979
38regulation of regulatory T cell differentiation (GO:0045589)3.88952832
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85337102
40positive regulation of meiosis (GO:0045836)3.85231023
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.85010088
42regulation of alpha-beta T cell proliferation (GO:0046640)3.83676273
43DNA deamination (GO:0045006)3.78232724
44positive regulation of meiotic cell cycle (GO:0051446)3.74257680
45regulation of T cell mediated cytotoxicity (GO:0001914)3.71452770
46oogenesis (GO:0048477)3.70460426
47positive regulation of defense response to virus by host (GO:0002230)3.70300169
48positive regulation of B cell differentiation (GO:0045579)3.69720083
49cilium or flagellum-dependent cell motility (GO:0001539)3.68872597
50regulation of synaptic vesicle exocytosis (GO:2000300)3.68859859
51microtubule depolymerization (GO:0007019)3.65541124
52* meiotic cell cycle process (GO:1903046)3.64159939
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.62058041
54regulation of meiosis (GO:0040020)3.61190628
55immunoglobulin mediated immune response (GO:0016064)3.57985081
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.56949913
57interferon-gamma production (GO:0032609)3.55334281
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.55297662
59regulation of B cell differentiation (GO:0045577)3.54172889
60positive thymic T cell selection (GO:0045059)3.53565658
61regulation of T cell tolerance induction (GO:0002664)3.53260966
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.52545856
63positive T cell selection (GO:0043368)3.50495654
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.50198079
65mitotic metaphase plate congression (GO:0007080)3.47499987
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.47495950
67reciprocal DNA recombination (GO:0035825)3.45711557
68reciprocal meiotic recombination (GO:0007131)3.45711557
69vitamin transmembrane transport (GO:0035461)3.44720772
70negative regulation of interleukin-12 production (GO:0032695)3.42111423
71monoubiquitinated protein deubiquitination (GO:0035520)3.37877666
72negative regulation of T cell mediated immunity (GO:0002710)3.37448794
73type I interferon signaling pathway (GO:0060337)3.33702309
74cellular response to type I interferon (GO:0071357)3.33702309
75NIK/NF-kappaB signaling (GO:0038061)3.31977067
76mast cell activation (GO:0045576)3.31549776
77positive regulation of synapse maturation (GO:0090129)3.30914334
78response to type I interferon (GO:0034340)3.30095997
79meiotic cell cycle (GO:0051321)3.29907624
80positive regulation of neurotransmitter transport (GO:0051590)3.28147541
81cerebellar granule cell differentiation (GO:0021707)3.26443707
82axonemal dynein complex assembly (GO:0070286)3.25735766
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25488786
84attachment of spindle microtubules to kinetochore (GO:0008608)3.25460654
85T cell selection (GO:0045058)3.25456923
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22375402
87regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21622437
88regulation of synaptic vesicle transport (GO:1902803)3.20731092
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20283054
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.19514808
91regulation of natural killer cell mediated immunity (GO:0002715)3.19514808
92antigen receptor-mediated signaling pathway (GO:0050851)3.19436739
93* spermatid development (GO:0007286)3.18615200
94purine nucleobase biosynthetic process (GO:0009113)3.18349887
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.18068622
96negative regulation of leukocyte mediated immunity (GO:0002704)3.17676272
97calcium ion-dependent exocytosis (GO:0017156)3.17387923
98T cell receptor signaling pathway (GO:0050852)3.17284185
99thymic T cell selection (GO:0045061)3.16958739
100synaptic vesicle exocytosis (GO:0016079)3.16026212
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.16000052
102lymphocyte chemotaxis (GO:0048247)3.14664520
103fusion of sperm to egg plasma membrane (GO:0007342)3.14418096
104gene silencing by RNA (GO:0031047)3.14177103
105positive regulation of tolerance induction (GO:0002645)3.13447595
106DNA synthesis involved in DNA repair (GO:0000731)3.12973289
107sex differentiation (GO:0007548)3.12367534
108acrosome reaction (GO:0007340)3.12357208
109defense response to protozoan (GO:0042832)3.11711256
110regulation of T cell receptor signaling pathway (GO:0050856)3.09456289
111regulation of tolerance induction (GO:0002643)3.09052711
112positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.08983904
113peptidyl-threonine dephosphorylation (GO:0035970)3.08684063
114regulation of antigen processing and presentation (GO:0002577)3.08400792
115regulation of interleukin-2 biosynthetic process (GO:0045076)3.07328143
116regulation of cell killing (GO:0031341)3.05145993
117DNA alkylation (GO:0006305)3.04949160
118DNA methylation (GO:0006306)3.04949160
119regulation of meiotic cell cycle (GO:0051445)3.03340964
120lymphocyte migration (GO:0072676)3.03322504
121activated T cell proliferation (GO:0050798)3.03317347
122B cell receptor signaling pathway (GO:0050853)3.02178849
123negative regulation of T cell apoptotic process (GO:0070233)3.01111569
124T cell costimulation (GO:0031295)3.00988187
125Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00421470
126sperm motility (GO:0030317)2.99950615
127DNA replication checkpoint (GO:0000076)2.99810852
128interferon-gamma-mediated signaling pathway (GO:0060333)2.98291712
129regulation of chronic inflammatory response (GO:0002676)2.97951825
130lymphocyte costimulation (GO:0031294)2.97101623
131positive regulation of antigen processing and presentation (GO:0002579)2.96556201
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95607916
133dendritic cell chemotaxis (GO:0002407)2.95033603
134regulation of activation of Janus kinase activity (GO:0010533)2.93679516
135neutrophil activation (GO:0042119)2.92972254
136B cell mediated immunity (GO:0019724)2.92297049
137positive regulation of interleukin-2 production (GO:0032743)2.91079399
138positive regulation of cell killing (GO:0031343)2.90871266
139positive regulation of granulocyte differentiation (GO:0030854)2.90382222
140positive regulation of chromosome segregation (GO:0051984)2.90259340
141negative regulation of meiotic cell cycle (GO:0051447)2.88502201
142chemokine-mediated signaling pathway (GO:0070098)2.88359670
143myeloid dendritic cell activation (GO:0001773)2.88028784
144regulation of lymphocyte chemotaxis (GO:1901623)2.87627006
145cellular extravasation (GO:0045123)2.84924587
146granulocyte activation (GO:0036230)2.84150075
147regulation of T cell mediated immunity (GO:0002709)2.83505594
148response to protozoan (GO:0001562)2.83496923
149detection of bacterium (GO:0016045)2.83304649
150ventricular cardiac muscle cell development (GO:0055015)2.82643045
151regulation of isotype switching to IgG isotypes (GO:0048302)2.82593914
152positive regulation of lymphocyte migration (GO:2000403)2.82239565
153negative regulation of viral genome replication (GO:0045071)2.82074761
154response to interferon-beta (GO:0035456)2.81258726
155female gamete generation (GO:0007292)2.80189971
156positive regulation of T cell mediated immunity (GO:0002711)2.79948165
157regulation of interleukin-12 biosynthetic process (GO:0045075)2.79736819
158positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79547182
159detection of other organism (GO:0098543)2.78856780
160response to histamine (GO:0034776)2.77198012
161positive regulation of cardiac muscle tissue growth (GO:0055023)2.76986108
162regulation of spindle organization (GO:0090224)2.76457463
1637-methylguanosine mRNA capping (GO:0006370)2.74983261
164regulation of synapse maturation (GO:0090128)2.74670673
165protein localization to chromosome, centromeric region (GO:0071459)2.74309960
166sister chromatid cohesion (GO:0007062)2.74155928
167transcription elongation from RNA polymerase III promoter (GO:0006385)2.73053474
168termination of RNA polymerase III transcription (GO:0006386)2.73053474
169neurotransmitter-gated ion channel clustering (GO:0072578)2.72374048
170regulation of glutamate receptor signaling pathway (GO:1900449)2.71184007
171inner cell mass cell proliferation (GO:0001833)2.69895768
172metaphase plate congression (GO:0051310)2.69205834
173regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68815829
174kinetochore assembly (GO:0051382)2.67718644
175regulation of chromosome segregation (GO:0051983)2.64798215
176protein localization to synapse (GO:0035418)2.62878810
177RNA capping (GO:0036260)2.62221914
1787-methylguanosine RNA capping (GO:0009452)2.62221914
179microtubule polymerization or depolymerization (GO:0031109)2.62159239
180nucleobase biosynthetic process (GO:0046112)2.60555074
181plasma membrane fusion (GO:0045026)2.59375415
182autophagic vacuole assembly (GO:0000045)2.59350480
183* germ cell development (GO:0007281)2.58142683
184regulation of neurotransmitter secretion (GO:0046928)2.56299214
185cardiac left ventricle morphogenesis (GO:0003214)2.55235468
186spermatogenesis (GO:0007283)2.54862642
187male gamete generation (GO:0048232)2.54832963
188epithelial cilium movement (GO:0003351)2.54790106
189synaptic transmission, glutamatergic (GO:0035249)2.54747738
190negative regulation of inclusion body assembly (GO:0090084)2.53923940
191regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52179791
192positive regulation of heart growth (GO:0060421)2.49914188
193presynaptic membrane assembly (GO:0097105)2.48019576
194meiotic chromosome segregation (GO:0045132)2.47715444
195vocalization behavior (GO:0071625)2.47272705
196negative regulation of macroautophagy (GO:0016242)2.45958734
197ribosome biogenesis (GO:0042254)2.43900566
198nuclear pore organization (GO:0006999)2.43896920
199intra-S DNA damage checkpoint (GO:0031573)2.43720777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.16808885
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.03140153
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.98845890
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.93134600
5EZH2_22144423_ChIP-Seq_EOC_Human4.76852747
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28761455
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24661877
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.11109735
9RUNX_20019798_ChIP-Seq_JUKART_Human3.43535319
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41045956
11MYB_26560356_Chip-Seq_TH2_Human3.08072428
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79490653
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73021352
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61979301
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57839791
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55633069
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54276442
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52573698
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.50779237
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48130609
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.37268457
22GATA3_27048872_Chip-Seq_THYMUS_Human2.26520935
23E2F7_22180533_ChIP-Seq_HELA_Human2.25352634
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23071989
25MYB_26560356_Chip-Seq_TH1_Human2.21955457
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.21700905
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21636553
28GATA1_26923725_Chip-Seq_HPCs_Mouse2.18585428
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17615352
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16317063
31GATA3_26560356_Chip-Seq_TH2_Human2.16181602
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15044586
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14321164
34* REST_21632747_ChIP-Seq_MESCs_Mouse2.10186665
35SPI1_23547873_ChIP-Seq_NB4_Human2.03963007
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01514701
37PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01272371
38GBX2_23144817_ChIP-Seq_PC3_Human1.98696841
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96269305
40RNF2_27304074_Chip-Seq_NSC_Mouse1.96154431
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95569388
42MAF_26560356_Chip-Seq_TH1_Human1.94855638
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93842068
44UTX_26944678_Chip-Seq_JUKART_Human1.92528974
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.89255414
46TAF15_26573619_Chip-Seq_HEK293_Human1.86002485
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81854345
48SCL_19346495_ChIP-Seq_HPC-7_Human1.78131941
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77071771
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76522821
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75914667
52FUS_26573619_Chip-Seq_HEK293_Human1.73524898
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72229119
54* MAF_26560356_Chip-Seq_TH2_Human1.68645177
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.67825866
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66919435
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64489455
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63613571
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62531034
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59350062
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57204463
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.56257042
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52953007
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.52294698
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49757170
66RUNX1_26923725_Chip-Seq_HPCs_Mouse1.46549013
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44950055
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43663331
69SPI1_23127762_ChIP-Seq_K562_Human1.43060591
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.42052231
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42029281
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.41403651
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37626538
74* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34273660
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33924844
76BCL6_27268052_Chip-Seq_Bcells_Human1.31900228
77VDR_24787735_ChIP-Seq_THP-1_Human1.31823177
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31248363
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.30706532
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30447574
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29626838
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27939014
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.26906242
84VDR_24763502_ChIP-Seq_THP-1_Human1.26118597
85KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23615844
86AR_21909140_ChIP-Seq_LNCAP_Human1.23511500
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.22624192
88VDR_23849224_ChIP-Seq_CD4+_Human1.22329689
89ZNF274_21170338_ChIP-Seq_K562_Hela1.21752080
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21213965
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20936675
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20936675
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20213187
94CIITA_25753668_ChIP-Seq_RAJI_Human1.20205947
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.18881726
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17644351
97SOX9_26525672_Chip-Seq_HEART_Mouse1.16868724
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16657025
99GATA3_26560356_Chip-Seq_TH1_Human1.15220270
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14964472
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14358789
102SMRT_27268052_Chip-Seq_Bcells_Human1.13488799
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12302821
104SMAD4_21799915_ChIP-Seq_A2780_Human1.11313519
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.11087714
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10398120
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10073268
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.10004613
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09982943
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09788483
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09175646
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09014319
113BCOR_27268052_Chip-Seq_Bcells_Human1.08903473
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08161458
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08156803
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07969514
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.07877091
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07482755
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07464872
120STAT3_23295773_ChIP-Seq_U87_Human1.06776450
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05818009
122BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05098693
123GF1_26923725_Chip-Seq_HPCs_Mouse1.02951251
124P300_27268052_Chip-Seq_Bcells_Human1.02561648
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02129627
126DROSHA_22980978_ChIP-Seq_HELA_Human1.01998548
127TCF4_23295773_ChIP-Seq_U87_Human1.01835061
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01787775
129* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01606735
130RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01371592
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01064055
132* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99518141
133ETS1_20019798_ChIP-Seq_JURKAT_Human0.99151064
134SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99138452
135EZH2_27304074_Chip-Seq_ESCs_Mouse0.98866488
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98819962
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98408502
138ETV1_20927104_ChIP-Seq_GIST48_Human0.98116057
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97334930
140MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96693416
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.96609290
142VDR_21846776_ChIP-Seq_THP-1_Human0.96381177
143WDR5_24793694_ChIP-Seq_LNCAP_Human0.95761617
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95604992
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95567251
146NMYC_18555785_Chip-Seq_ESCs_Mouse0.95537984
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95329159
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94995782
149TET1_21490601_ChIP-Seq_MESCs_Mouse0.94766357
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94281599
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94165246
152SOX2_18555785_Chip-Seq_ESCs_Mouse0.93749779
153JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93379269
154SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93341125
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92970659
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.92761484
157EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92430977
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89531896
159SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89056594
160FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.89008501
161* OCT4_19829295_ChIP-Seq_ESCs_Human0.88988432
162NANOG_20526341_ChIP-Seq_ESCs_Human0.88855681
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88843713
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.87762516
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.87119978
166* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86860703
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.86856602
168P300_19829295_ChIP-Seq_ESCs_Human0.86562181
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.86434929
170ER_23166858_ChIP-Seq_MCF-7_Human0.86165242
171TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86044662
172EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85507510
173VDR_22108803_ChIP-Seq_LS180_Human0.85443743
174GATA3_21867929_ChIP-Seq_TH1_Mouse0.85394580
175ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84931555
176EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84831597
177MYC_22102868_ChIP-Seq_BL_Human0.83472532
178YY1_22570637_ChIP-Seq_MALME-3M_Human0.82909375
179PRDM14_20953172_ChIP-Seq_ESCs_Human0.82045143
180EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81780942
181GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81412532
182TP53_22573176_ChIP-Seq_HFKS_Human0.81164585
183TAF2_19829295_ChIP-Seq_ESCs_Human0.80609371
184SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80061331
185GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79997506
186ERA_21632823_ChIP-Seq_H3396_Human0.79986864
187PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79878952
188STAT1_20625510_ChIP-Seq_HELA_Human0.79847347
189GATA3_21878914_ChIP-Seq_MCF-7_Human0.79364919
190* FOXP3_21729870_ChIP-Seq_TREG_Human0.79259077
191STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79019222
192PU_27001747_Chip-Seq_BMDM_Mouse0.78595092
193SPI1_20517297_ChIP-Seq_HL60_Human0.78540551
194NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78504911
195TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78348822
196RAC3_21632823_ChIP-Seq_H3396_Human0.78201371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.10016991
2MP0005671_abnormal_response_to4.60330414
3MP0004859_abnormal_synaptic_plasticity3.90740412
4MP0001835_abnormal_antigen_presentation3.80827173
5MP0003763_abnormal_thymus_physiology3.45409834
6MP0009785_altered_susceptibility_to3.36112143
7MP0003436_decreased_susceptibility_to3.31851052
8MP0001800_abnormal_humoral_immune3.28397930
9MP0005000_abnormal_immune_tolerance3.16787931
10MP0008995_early_reproductive_senescence3.08961799
11MP0003880_abnormal_central_pattern3.07713338
12MP0003724_increased_susceptibility_to3.05897408
13MP0001790_abnormal_immune_system2.99488780
14MP0005387_immune_system_phenotype2.99488780
15MP0002148_abnormal_hypersensitivity_rea2.96245941
16MP0000685_abnormal_immune_system2.89652099
17MP0002723_abnormal_immune_serum2.88784812
18MP0005410_abnormal_fertilization2.83107468
19MP0003693_abnormal_embryo_hatching2.78103450
20MP0005025_abnormal_response_to2.77062960
21MP0002420_abnormal_adaptive_immunity2.69057126
22* MP0002210_abnormal_sex_determination2.68544504
23MP0003879_abnormal_hair_cell2.66153596
24MP0001819_abnormal_immune_cell2.65174944
25MP0008260_abnormal_autophagy2.64182011
26* MP0001929_abnormal_gametogenesis2.63473745
27MP0002452_abnormal_antigen_presenting2.63233258
28MP0003111_abnormal_nucleus_morphology2.62795480
29MP0001968_abnormal_touch/_nociception2.56350844
30MP0006082_CNS_inflammation2.54730068
31MP0009333_abnormal_splenocyte_physiolog2.51151245
32MP0002419_abnormal_innate_immunity2.45972384
33* MP0003698_abnormal_male_reproductive2.45207229
34MP0003635_abnormal_synaptic_transmissio2.41649981
35MP0010094_abnormal_chromosome_stability2.38141038
36MP0004270_analgesia2.34295868
37MP0005377_hearing/vestibular/ear_phenot2.30308301
38MP0003878_abnormal_ear_physiology2.30308301
39MP0009046_muscle_twitch2.28541757
40MP0002736_abnormal_nociception_after2.19941612
41MP0003786_premature_aging2.17689573
42* MP0001145_abnormal_male_reproductive2.14231970
43MP0000716_abnormal_immune_system2.05399584
44MP0002398_abnormal_bone_marrow2.04963351
45MP0010155_abnormal_intestine_physiology2.04197252
46MP0002405_respiratory_system_inflammati2.04195223
47MP0009745_abnormal_behavioral_response2.00028540
48MP0003123_paternal_imprinting1.97676425
49* MP0000653_abnormal_sex_gland1.95322663
50MP0002063_abnormal_learning/memory/cond1.93959071
51MP0001440_abnormal_grooming_behavior1.89662143
52MP0002064_seizures1.88430700
53MP0005464_abnormal_platelet_physiology1.87028338
54MP0003787_abnormal_imprinting1.85868798
55MP0001845_abnormal_inflammatory_respons1.84243126
56MP0005310_abnormal_salivary_gland1.83890691
57MP0003866_abnormal_defecation1.83530514
58MP0003303_peritoneal_inflammation1.79630130
59MP0000689_abnormal_spleen_morphology1.78639760
60MP0002572_abnormal_emotion/affect_behav1.76853956
61MP0009764_decreased_sensitivity_to1.72674220
62MP0003718_maternal_effect1.71191882
63MP0008058_abnormal_DNA_repair1.70695932
64MP0002166_altered_tumor_susceptibility1.70649874
65MP0002722_abnormal_immune_system1.69804471
66MP0002822_catalepsy1.68711344
67MP0000703_abnormal_thymus_morphology1.64703075
68MP0000465_gastrointestinal_hemorrhage1.64220336
69MP0004957_abnormal_blastocyst_morpholog1.60833747
70MP0001873_stomach_inflammation1.60307867
71MP0002734_abnormal_mechanical_nocicepti1.59952168
72MP0002138_abnormal_hepatobiliary_system1.58605599
73MP0004947_skin_inflammation1.58415886
74MP0002429_abnormal_blood_cell1.57991583
75MP0003077_abnormal_cell_cycle1.57853835
76MP0002653_abnormal_ependyma_morphology1.57112021
77* MP0002161_abnormal_fertility/fecundity1.55887120
78MP0002272_abnormal_nervous_system1.51896863
79MP0001533_abnormal_skeleton_physiology1.49792639
80MP0003300_gastrointestinal_ulcer1.44075159
81MP0008469_abnormal_protein_level1.43163249
82MP0002160_abnormal_reproductive_system1.38804635
83MP0001486_abnormal_startle_reflex1.36148449
84MP0004885_abnormal_endolymph1.35561429
85MP0003183_abnormal_peptide_metabolism1.34988377
86MP0002277_abnormal_respiratory_mucosa1.31626164
87MP0003172_abnormal_lysosome_physiology1.30032397
88MP0001502_abnormal_circadian_rhythm1.28725092
89MP0002006_tumorigenesis1.27519528
90MP0005075_abnormal_melanosome_morpholog1.23719133
91MP0001986_abnormal_taste_sensitivity1.22375797
92MP0002735_abnormal_chemical_nociception1.21104488
93MP0001661_extended_life_span1.20294701
94MP0004742_abnormal_vestibular_system1.19355751
95MP0008569_lethality_at_weaning1.18234298
96MP0000569_abnormal_digit_pigmentation1.17145001
97MP0002067_abnormal_sensory_capabilities1.16774270
98MP0008057_abnormal_DNA_replication1.15794570
99MP0009278_abnormal_bone_marrow1.14428958
100MP0004381_abnormal_hair_follicle1.11349921
101MP0002733_abnormal_thermal_nociception1.06480650
102MP0003045_fibrosis1.06158236
103MP0001730_embryonic_growth_arrest1.05824142
104MP0002933_joint_inflammation1.05360893
105MP0005167_abnormal_blood-brain_barrier1.05227808
106MP0001485_abnormal_pinna_reflex1.01062175
107MP0001188_hyperpigmentation0.99526120
108MP0002102_abnormal_ear_morphology0.99420607
109MP0004811_abnormal_neuron_physiology0.98918017
110MP0001853_heart_inflammation0.98138878
111MP0001529_abnormal_vocalization0.97183783
112MP0002127_abnormal_cardiovascular_syste0.96440371
113MP0001501_abnormal_sleep_pattern0.96073722
114MP0000015_abnormal_ear_pigmentation0.95087549
115MP0009384_cardiac_valve_regurgitation0.94660660
116MP0008007_abnormal_cellular_replicative0.92131619
117MP0005423_abnormal_somatic_nervous0.91533612
118MP0003448_altered_tumor_morphology0.91077858
119MP0003121_genomic_imprinting0.90442077
120MP0002184_abnormal_innervation0.89961185
121MP0001970_abnormal_pain_threshold0.88982535
122MP0002998_abnormal_bone_remodeling0.87833281
123MP0010307_abnormal_tumor_latency0.87273569
124MP0008872_abnormal_physiological_respon0.86621554
125MP0004145_abnormal_muscle_electrophysio0.85349515
126* MP0003699_abnormal_female_reproductive0.85307986
127MP0000778_abnormal_nervous_system0.85109959
128MP0008004_abnormal_stomach_pH0.84266684
129MP0009765_abnormal_xenobiotic_induced0.84018603
130MP0001851_eye_inflammation0.83376314
131MP0001905_abnormal_dopamine_level0.82698972
132MP0002557_abnormal_social/conspecific_i0.82131224
133MP0005623_abnormal_meninges_morphology0.82044662
134MP0001119_abnormal_female_reproductive0.80495121
135MP0002163_abnormal_gland_morphology0.80296776
136MP0009763_increased_sensitivity_to0.80061054
137MP0000604_amyloidosis0.78301951
138MP0005166_decreased_susceptibility_to0.78208824
139MP0003315_abnormal_perineum_morphology0.78019211
140MP0002132_abnormal_respiratory_system0.77562689
141MP0000858_altered_metastatic_potential0.77214096
142MP0004924_abnormal_behavior0.76684206
143MP0005386_behavior/neurological_phenoty0.76684206
144MP0001545_abnormal_hematopoietic_system0.75945219
145MP0005397_hematopoietic_system_phenotyp0.75945219
146MP0009780_abnormal_chondrocyte_physiolo0.75860970
147MP0002066_abnormal_motor_capabilities/c0.74922546
148MP0005389_reproductive_system_phenotype0.74257131
149MP0001919_abnormal_reproductive_system0.74128328
150MP0002693_abnormal_pancreas_physiology0.73957200
151MP0002882_abnormal_neuron_morphology0.73471056
152MP0001672_abnormal_embryogenesis/_devel0.72611371
153MP0005380_embryogenesis_phenotype0.72611371
154MP0001963_abnormal_hearing_physiology0.72374184
155MP0005174_abnormal_tail_pigmentation0.72261196
156MP0003075_altered_response_to0.72029485
157MP0003941_abnormal_skin_development0.72009806
158MP0006138_congestive_heart_failure0.70774278
159MP0005646_abnormal_pituitary_gland0.70193609
160MP0000343_altered_response_to0.69976549
161MP0002019_abnormal_tumor_incidence0.69815156
162MP0002152_abnormal_brain_morphology0.68845838
163MP0005058_abnormal_lysosome_morphology0.68369957
164MP0002254_reproductive_system_inflammat0.68272333
165MP0008932_abnormal_embryonic_tissue0.68242256
166MP0005647_abnormal_sex_gland0.67695176
167MP0000427_abnormal_hair_cycle0.67203826
168MP0005171_absent_coat_pigmentation0.67130935
169MP0001663_abnormal_digestive_system0.66899987
170MP0003221_abnormal_cardiomyocyte_apopto0.65846082
171MP0004510_myositis0.65317445
172MP0000751_myopathy0.65308167
173MP0003646_muscle_fatigue0.63484356
174MP0003984_embryonic_growth_retardation0.62633248
175MP0005379_endocrine/exocrine_gland_phen0.60897247
176MP0003861_abnormal_nervous_system0.59678002
177MP0005451_abnormal_body_composition0.59382119
178MP0002876_abnormal_thyroid_physiology0.58595960
179MP0003191_abnormal_cellular_cholesterol0.55914792
180MP0008874_decreased_physiological_sensi0.54204724
181MP0001764_abnormal_homeostasis0.53472977
182MP0002095_abnormal_skin_pigmentation0.52556153
183MP0003795_abnormal_bone_structure0.52430152
184MP0000249_abnormal_blood_vessel0.51338453
185MP0001765_abnormal_ion_homeostasis0.50004381
186MP0002009_preneoplasia0.49924810
187MP0002136_abnormal_kidney_physiology0.49833896
188MP0008873_increased_physiological_sensi0.48573413

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.92703046
2Stomatitis (HP:0010280)5.26139539
3Elevated erythrocyte sedimentation rate (HP:0003565)5.12165026
4T lymphocytopenia (HP:0005403)4.84287235
5Azoospermia (HP:0000027)4.74207199
6Abnormality of T cell number (HP:0011839)4.72435795
7Abnormal spermatogenesis (HP:0008669)4.53495187
8Impulsivity (HP:0100710)4.42206174
9Abnormality of the lower motor neuron (HP:0002366)4.19460747
10Myositis (HP:0100614)4.14404051
11Abnormality of the labia minora (HP:0012880)4.09830005
12IgG deficiency (HP:0004315)4.02978650
13Recurrent bacterial skin infections (HP:0005406)4.01752691
14Abnormality of macrophages (HP:0004311)3.96906198
15Abnormality of T cells (HP:0002843)3.92771148
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.89192933
17Absent/shortened dynein arms (HP:0200106)3.89192933
18Optic neuritis (HP:0100653)3.88235001
19Retrobulbar optic neuritis (HP:0100654)3.88235001
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.85437847
21Eczematoid dermatitis (HP:0000976)3.84547217
22Recurrent fungal infections (HP:0002841)3.79865840
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.77231324
24Recurrent abscess formation (HP:0002722)3.74140743
25Male infertility (HP:0003251)3.71727679
26Orchitis (HP:0100796)3.67952357
27Autoimmune hemolytic anemia (HP:0001890)3.60518014
28Severe combined immunodeficiency (HP:0004430)3.60026966
29Focal seizures (HP:0007359)3.59923541
30Gastrointestinal infarctions (HP:0005244)3.55470752
31Recurrent cutaneous fungal infections (HP:0011370)3.53803097
32Chronic mucocutaneous candidiasis (HP:0002728)3.53803097
33Vasculitis (HP:0002633)3.48472315
34Meningitis (HP:0001287)3.48108239
35Mediastinal lymphadenopathy (HP:0100721)3.46437542
36Pustule (HP:0200039)3.45764962
37Epileptic encephalopathy (HP:0200134)3.44585663
38Infertility (HP:0000789)3.37373102
39Leukocytosis (HP:0001974)3.33693835
40Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30180502
41Recurrent bronchitis (HP:0002837)3.28278144
42Abnormality of eosinophils (HP:0001879)3.23973344
43Increased IgM level (HP:0003496)3.23572420
44Chronic diarrhea (HP:0002028)3.23188441
45Panhypogammaglobulinemia (HP:0003139)3.21194495
46Gonadotropin excess (HP:0000837)3.19755434
47Agammaglobulinemia (HP:0004432)3.18863701
48Recurrent skin infections (HP:0001581)3.17301956
49Chronic obstructive pulmonary disease (HP:0006510)3.16524017
50Obstructive lung disease (HP:0006536)3.16524017
51Encephalitis (HP:0002383)3.15392920
52Birth length less than 3rd percentile (HP:0003561)3.11555383
53Chromsome breakage (HP:0040012)3.08371410
54Abnormality of T cell physiology (HP:0011840)3.07911021
55Eosinophilia (HP:0001880)3.06447794
56Shoulder girdle muscle weakness (HP:0003547)3.06019842
57Abnormality of B cell number (HP:0010975)3.05662531
58Combined immunodeficiency (HP:0005387)3.01715631
59Pulmonary infiltrates (HP:0002113)3.00325329
60Granulocytopenia (HP:0001913)2.98397218
61Abnormal respiratory motile cilium physiology (HP:0012261)2.96828410
62Gaze-evoked nystagmus (HP:0000640)2.96202521
63Recurrent viral infections (HP:0004429)2.94433518
64Myokymia (HP:0002411)2.92544084
65Hemoptysis (HP:0002105)2.90535442
66IgM deficiency (HP:0002850)2.89636854
67Abnormal respiratory epithelium morphology (HP:0012253)2.88712080
68Abnormal respiratory motile cilium morphology (HP:0005938)2.88712080
69Abnormality of the prostate (HP:0008775)2.85266538
70Keratoconjunctivitis (HP:0001096)2.82477696
71Cerebral hypomyelination (HP:0006808)2.81498194
72Autoimmune thrombocytopenia (HP:0001973)2.81268277
73Breast hypoplasia (HP:0003187)2.80714899
74Keratoconjunctivitis sicca (HP:0001097)2.79829612
75Visual hallucinations (HP:0002367)2.74893546
76Bundle branch block (HP:0011710)2.68867341
77Facial cleft (HP:0002006)2.67644314
78Atonic seizures (HP:0010819)2.67438781
79Generalized tonic-clonic seizures (HP:0002069)2.66433175
80Lymphopenia (HP:0001888)2.66343139
81Thyroiditis (HP:0100646)2.65292051
82Febrile seizures (HP:0002373)2.64551965
83B lymphocytopenia (HP:0010976)2.63862224
84Ventricular fibrillation (HP:0001663)2.62381995
85Abnormal hair whorl (HP:0010721)2.59271183
86Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58452304
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.55772089
88Breast aplasia (HP:0100783)2.54686253
89Abnormal ciliary motility (HP:0012262)2.53616486
90Rhinitis (HP:0012384)2.52973176
91Recurrent sinusitis (HP:0011108)2.51561780
92Joint swelling (HP:0001386)2.49099723
93Chest pain (HP:0100749)2.46778833
94Oligodactyly (hands) (HP:0001180)2.39024222
95Gangrene (HP:0100758)2.36830159
96Dialeptic seizures (HP:0011146)2.36030839
97Recurrent gram-negative bacterial infections (HP:0005420)2.35561597
98Aplasia/Hypoplasia of the breasts (HP:0010311)2.35263934
99Pelvic girdle muscle weakness (HP:0003749)2.34523204
100Hyperglycinemia (HP:0002154)2.32175628
101Hyperventilation (HP:0002883)2.29115680
102Hematochezia (HP:0002573)2.27607550
103Abnormality of the hip-girdle musculature (HP:0001445)2.24714525
104Abnormality of the musculature of the pelvis (HP:0001469)2.24714525
105Patellar aplasia (HP:0006443)2.21791924
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.20911186
107Premature ovarian failure (HP:0008209)2.20757946
108IgA deficiency (HP:0002720)2.20624444
109Hypoplasia of the thymus (HP:0000778)2.20274271
110Facial hemangioma (HP:0000329)2.19540464
111Broad-based gait (HP:0002136)2.19513527
112Pulmonary embolism (HP:0002204)2.18512376
113Nephronophthisis (HP:0000090)2.17463363
114Anorexia (HP:0002039)2.17438784
115Inflammation of the large intestine (HP:0002037)2.16654998
116Urticaria (HP:0001025)2.16018851
117Dysmetric saccades (HP:0000641)2.15836823
118Arterial thrombosis (HP:0004420)2.13924287
119Oligodactyly (HP:0012165)2.12718988
120Abnormality of the preputium (HP:0100587)2.12212139
121Hypergammaglobulinemia (HP:0010702)2.12174321
122Progressive cerebellar ataxia (HP:0002073)2.11909378
123Fatigue (HP:0012378)2.11877371
124Ureteral duplication (HP:0000073)2.11553705
125Gastrointestinal stroma tumor (HP:0100723)2.11401077
126Polyneuropathy (HP:0001271)2.11079676
127Spinal muscular atrophy (HP:0007269)2.11020028
128Papillary thyroid carcinoma (HP:0002895)2.09496924
129Aplasia/Hypoplasia of the patella (HP:0006498)2.09247191
130Abnormality of the pleura (HP:0002103)2.09046411
131Inability to walk (HP:0002540)2.08815618
132Amyotrophic lateral sclerosis (HP:0007354)2.08783248
133Increased IgE level (HP:0003212)2.08407189
134Increased cerebral lipofuscin (HP:0011813)2.08288302
135Urinary bladder sphincter dysfunction (HP:0002839)2.08042563
136Spontaneous hematomas (HP:0007420)2.06331318
137Episodic fever (HP:0001954)2.06189040
138Carpal bone hypoplasia (HP:0001498)2.04593344
139Tetraplegia (HP:0002445)2.04305837
140Atrioventricular block (HP:0001678)2.02786434
141Keratitis (HP:0000491)2.02717780
142Tongue fasciculations (HP:0001308)2.02463541
143Ankle clonus (HP:0011448)2.01832407
144Lymphoma (HP:0002665)2.01441436
145Bronchitis (HP:0012387)2.00877748
146Delusions (HP:0000746)2.00052893
147Skin rash (HP:0000988)1.99723193
148Gastrointestinal inflammation (HP:0004386)1.98267748
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97284915
150Absence seizures (HP:0002121)1.96872307
151Stomach cancer (HP:0012126)1.95548664
152Prostate neoplasm (HP:0100787)1.95292911
153Epistaxis (HP:0000421)1.95064344
154Hypochromic anemia (HP:0001931)1.93124990
155Prolonged bleeding time (HP:0003010)1.92515296
156Hypoproteinemia (HP:0003075)1.92445669
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92114804
158Absent epiphyses (HP:0010577)1.92114804
159Recurrent pneumonia (HP:0006532)1.92100626
160Acute hepatic failure (HP:0006554)1.91960464
161Pancreatic fibrosis (HP:0100732)1.91021646
162Meckel diverticulum (HP:0002245)1.90339604
163Papilloma (HP:0012740)1.89934841
164Verrucae (HP:0200043)1.89934841
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89728019
166Vacuolated lymphocytes (HP:0001922)1.88273431
167Petechiae (HP:0000967)1.87471368
168CNS hypomyelination (HP:0003429)1.86395887
169Degeneration of anterior horn cells (HP:0002398)1.86077037
170Abnormality of the anterior horn cell (HP:0006802)1.86077037
171Abnormality of ocular smooth pursuit (HP:0000617)1.85316925
172Chronic otitis media (HP:0000389)1.83209234
173Abnormality of liposaccharide metabolism (HP:0010968)1.82340623
174Abnormality of glycosphingolipid metabolism (HP:0004343)1.82340623
175Abnormality of glycolipid metabolism (HP:0010969)1.82340623
176Muscle fibrillation (HP:0010546)1.81106329
177Spontaneous abortion (HP:0005268)1.80984566
178Pulmonary fibrosis (HP:0002206)1.80765557
179Fetal akinesia sequence (HP:0001989)1.80168551
180Poor eye contact (HP:0000817)1.79691134
181Pendular nystagmus (HP:0012043)1.79375512
182Primary amenorrhea (HP:0000786)1.77681448
183Mutism (HP:0002300)1.75887078
184Impaired smooth pursuit (HP:0007772)1.74993333
185Unsteady gait (HP:0002317)1.74359759
186Abnormality of the ileum (HP:0001549)1.72450412
187Abnormal eating behavior (HP:0100738)1.72406396
188Drooling (HP:0002307)1.71591952
189Excessive salivation (HP:0003781)1.71591952
190Median cleft lip (HP:0000161)1.70757062
191Tubulointerstitial nephritis (HP:0001970)1.70382397
192Ankle contracture (HP:0006466)1.69329317
193Male pseudohermaphroditism (HP:0000037)1.68404696
194Areflexia of lower limbs (HP:0002522)1.68333749
195Microglossia (HP:0000171)1.68021557
196Small intestinal stenosis (HP:0012848)1.67361939
197Duodenal stenosis (HP:0100867)1.67361939
198Annular pancreas (HP:0001734)1.66737243
199Aplasia/Hypoplasia of the uvula (HP:0010293)1.66721891
200Broad distal phalanx of finger (HP:0009836)1.65625462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.25427558
2MAP4K14.52148161
3CASK4.21688218
4CCNB14.02253009
5DAPK23.27036001
6FES3.08112505
7TAOK33.05362327
8WEE12.87754073
9BUB12.74856047
10EPHA42.66673842
11AKT32.61389137
12PDK32.60872398
13PDK42.60872398
14NTRK32.36564378
15FRK2.36148200
16ITK2.33507814
17IKBKE2.30270000
18DAPK12.24967674
19BLK2.07981110
20SYK2.07683146
21TYK22.07324927
22MAP3K92.04353209
23MAP3K42.01022409
24MKNK21.99950984
25CAMKK21.99600502
26PRKD31.99484759
27CDC71.97755690
28CSK1.97120532
29IKBKB1.95240289
30GRK61.94882371
31CDK121.93274708
32PNCK1.92482470
33IRAK41.87654432
34JAK31.85673623
35BTK1.85386671
36CDK191.84838203
37MARK31.84334826
38NEK21.83260890
39CSF1R1.78562951
40PLK21.78282819
41TNK21.78162010
42MAP2K71.76052863
43TEC1.74617755
44MAP3K141.73755238
45ZAP701.73551317
46LCK1.71869984
47PLK31.66461649
48TBK11.61752860
49LYN1.56888408
50PDK21.54872856
51ADRBK21.48985592
52KIT1.47667708
53JAK11.47034075
54HCK1.46537617
55TSSK61.44722006
56BRSK11.40366451
57STK38L1.37922067
58FGR1.36135900
59SIK21.35740446
60KDR1.34742750
61BRSK21.34475325
62PRKCQ1.32502636
63TESK21.27374151
64NEK11.27193826
65STK381.22884682
66PLK11.21603957
67OXSR11.19368530
68CHEK21.15764877
69ZAK1.15033296
70MAP3K131.14349240
71CDK31.13457672
72PAK61.10352979
73MAP4K21.05561194
74BRD41.04343633
75STK101.03068806
76NLK1.01907756
77GRK71.01506037
78TTK0.98076034
79PIM10.97525154
80PINK10.97422573
81MAP3K110.97127357
82MKNK10.96846532
83TLK10.94992975
84ARAF0.94263716
85JAK20.93797540
86BCKDK0.93630550
87PRPF4B0.91310199
88MYLK0.87738314
89PLK40.86802705
90BRAF0.86093598
91STK110.86047794
92PTK2B0.85710886
93EIF2AK10.85615156
94TYRO30.85492812
95MINK10.85487459
96MAP2K40.85020979
97WNK30.81754238
98LATS20.81357234
99TAOK10.77677902
100SIK30.77472149
101MAPK110.75745691
102RIPK40.74612432
103CHEK10.74077449
104IRAK10.72448487
105PRKCG0.72216638
106VRK10.71083291
107DAPK30.69880147
108SRPK10.69856002
109KSR10.67667401
110ACVR1B0.65807239
111ERN10.65129791
112DYRK30.64727160
113ICK0.64595801
114ALK0.64108032
115EIF2AK30.62243568
116MATK0.61606682
117IRAK30.59950484
118CHUK0.59590362
119MAP3K60.59561757
120CDK50.58507059
121MAPK130.57850044
122CDK70.57813519
123FYN0.57248862
124GRK50.55727430
125BMPR20.55491705
126CDK180.54915213
127RAF10.54264318
128CDC42BPA0.53775599
129PIK3CG0.53111172
130NUAK10.52613272
131EPHA30.51952594
132CDK80.50478371
133MAP2K60.50405792
134PRKCH0.50100772
135CDK150.48967678
136MAPKAPK30.48793182
137MAP2K20.48414307
138HIPK20.48070024
139BMX0.47985724
140ATR0.47617325
141FGFR30.46672934
142MST40.45903769
143STK30.44999322
144AURKB0.44917751
145SGK20.44884353
146GRK10.44825744
147CSNK1E0.44424257
148INSRR0.43890515
149IGF1R0.43111550
150TNIK0.43047481
151CDK20.42521600
152CDK10.42462026
153AURKA0.42422133
154CDK11A0.42065780
155STK160.41857302
156NTRK20.40839870
157CAMK2A0.40665794
158EPHB10.40364723
159BCR0.40007546
160MARK10.39899188
161PDK10.38956538
162CDK140.38870652
163CAMKK10.38670328
164TGFBR20.38637135
165ABL10.38418492
166SGK4940.37693393
167SGK2230.37693393
168MAP2K30.36363286
169CDK40.36317302
170MAPK70.35407875
171PRKCD0.31153405
172INSR0.31067864
173MAPK120.30917732
174EGFR0.30869243
175MAP3K10.30362591
176MAP3K70.30091586
177PASK0.26575505
178RPS6KA50.26138833
179MAPKAPK20.25763920
180MAPK30.25121878

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.19320958
2Primary immunodeficiency_Homo sapiens_hsa053404.69210967
3Graft-versus-host disease_Homo sapiens_hsa053323.79534214
4Allograft rejection_Homo sapiens_hsa053303.63235861
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53213142
6Synaptic vesicle cycle_Homo sapiens_hsa047213.42681585
7Autoimmune thyroid disease_Homo sapiens_hsa053203.38121988
8RNA polymerase_Homo sapiens_hsa030203.26554429
9Basal transcription factors_Homo sapiens_hsa030222.95584833
10Type I diabetes mellitus_Homo sapiens_hsa049402.90202656
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.83494095
12Nicotine addiction_Homo sapiens_hsa050332.82012753
13Antigen processing and presentation_Homo sapiens_hsa046122.66278843
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.59224031
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43407956
16T cell receptor signaling pathway_Homo sapiens_hsa046602.42733388
17Collecting duct acid secretion_Homo sapiens_hsa049662.40612880
18RNA transport_Homo sapiens_hsa030132.34832616
19Asthma_Homo sapiens_hsa053102.32761879
20NF-kappa B signaling pathway_Homo sapiens_hsa040642.32339235
21Oocyte meiosis_Homo sapiens_hsa041142.31545787
22Leishmaniasis_Homo sapiens_hsa051402.24348665
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22771568
24Hematopoietic cell lineage_Homo sapiens_hsa046402.20973419
25Amphetamine addiction_Homo sapiens_hsa050312.19430263
26Osteoclast differentiation_Homo sapiens_hsa043802.14307735
27Regulation of autophagy_Homo sapiens_hsa041402.07827212
28Staphylococcus aureus infection_Homo sapiens_hsa051502.02115866
29NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01279503
30Measles_Homo sapiens_hsa051621.98536853
31Olfactory transduction_Homo sapiens_hsa047401.95196706
32Cell cycle_Homo sapiens_hsa041101.94846574
33Morphine addiction_Homo sapiens_hsa050321.82019985
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79458794
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79310415
36Long-term potentiation_Homo sapiens_hsa047201.78211404
37Circadian entrainment_Homo sapiens_hsa047131.72745704
38mRNA surveillance pathway_Homo sapiens_hsa030151.70640024
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65279060
40Viral myocarditis_Homo sapiens_hsa054161.64654707
41B cell receptor signaling pathway_Homo sapiens_hsa046621.64519573
42Fanconi anemia pathway_Homo sapiens_hsa034601.60716043
43Herpes simplex infection_Homo sapiens_hsa051681.55438495
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52953544
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51630731
46Dorso-ventral axis formation_Homo sapiens_hsa043201.50772349
47Tuberculosis_Homo sapiens_hsa051521.49228355
48TNF signaling pathway_Homo sapiens_hsa046681.42592131
49Chemokine signaling pathway_Homo sapiens_hsa040621.42051561
50Glutamatergic synapse_Homo sapiens_hsa047241.41941766
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.41131646
52Purine metabolism_Homo sapiens_hsa002301.39831116
53Circadian rhythm_Homo sapiens_hsa047101.37938347
54Renin secretion_Homo sapiens_hsa049241.36946474
55Spliceosome_Homo sapiens_hsa030401.36857682
56Insulin secretion_Homo sapiens_hsa049111.35466134
57Glycerophospholipid metabolism_Homo sapiens_hsa005641.31769163
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28481832
59Influenza A_Homo sapiens_hsa051641.27521033
60Dopaminergic synapse_Homo sapiens_hsa047281.26640323
61Homologous recombination_Homo sapiens_hsa034401.26191907
62Calcium signaling pathway_Homo sapiens_hsa040201.25639098
63GABAergic synapse_Homo sapiens_hsa047271.24513390
64Oxytocin signaling pathway_Homo sapiens_hsa049211.23467527
65Salivary secretion_Homo sapiens_hsa049701.21789575
66Vitamin digestion and absorption_Homo sapiens_hsa049771.20221966
67Malaria_Homo sapiens_hsa051441.20214142
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.13815647
69Toxoplasmosis_Homo sapiens_hsa051451.13156979
70Legionellosis_Homo sapiens_hsa051341.12318659
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09815479
72Proteasome_Homo sapiens_hsa030501.07993076
73Pyrimidine metabolism_Homo sapiens_hsa002401.07490748
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06369681
75Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05267366
76cAMP signaling pathway_Homo sapiens_hsa040241.04480507
77Taste transduction_Homo sapiens_hsa047421.03582310
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02369304
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02002709
80Gastric acid secretion_Homo sapiens_hsa049710.94268963
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93762416
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92590470
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89306989
84Inositol phosphate metabolism_Homo sapiens_hsa005620.87920342
85Cocaine addiction_Homo sapiens_hsa050300.87828564
86Lysosome_Homo sapiens_hsa041420.86902541
87Pentose phosphate pathway_Homo sapiens_hsa000300.84755588
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84542887
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82973036
90Phagosome_Homo sapiens_hsa041450.82447754
91Pertussis_Homo sapiens_hsa051330.81097531
92Salmonella infection_Homo sapiens_hsa051320.80922861
93Nucleotide excision repair_Homo sapiens_hsa034200.80531453
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79934673
95Epstein-Barr virus infection_Homo sapiens_hsa051690.78635467
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76591918
97Acute myeloid leukemia_Homo sapiens_hsa052210.76426104
98Serotonergic synapse_Homo sapiens_hsa047260.74819445
99Shigellosis_Homo sapiens_hsa051310.74261503
100Apoptosis_Homo sapiens_hsa042100.74071742
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.73986053
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73928182
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73718570
104Glucagon signaling pathway_Homo sapiens_hsa049220.71010062
105Cholinergic synapse_Homo sapiens_hsa047250.70179704
106African trypanosomiasis_Homo sapiens_hsa051430.68475679
107Phototransduction_Homo sapiens_hsa047440.68166640
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66591815
109RNA degradation_Homo sapiens_hsa030180.65882377
110Hepatitis C_Homo sapiens_hsa051600.65779050
111Hepatitis B_Homo sapiens_hsa051610.65701363
112Vibrio cholerae infection_Homo sapiens_hsa051100.64989026
113Estrogen signaling pathway_Homo sapiens_hsa049150.64191862
114Rheumatoid arthritis_Homo sapiens_hsa053230.63426269
115Linoleic acid metabolism_Homo sapiens_hsa005910.62270023
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61305333
117Mismatch repair_Homo sapiens_hsa034300.60338103
118p53 signaling pathway_Homo sapiens_hsa041150.59549928
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58045108
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57812392
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57535069
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.56925036
123Gap junction_Homo sapiens_hsa045400.55582974
124DNA replication_Homo sapiens_hsa030300.54209461
125Systemic lupus erythematosus_Homo sapiens_hsa053220.52883391
126Fatty acid biosynthesis_Homo sapiens_hsa000610.50562418
127HTLV-I infection_Homo sapiens_hsa051660.49691582
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49586147
129Glycerolipid metabolism_Homo sapiens_hsa005610.49196048
130Viral carcinogenesis_Homo sapiens_hsa052030.49024279
131Platelet activation_Homo sapiens_hsa046110.47375262
132Biosynthesis of amino acids_Homo sapiens_hsa012300.44498768
133GnRH signaling pathway_Homo sapiens_hsa049120.44131989
134Glioma_Homo sapiens_hsa052140.44011040
135Ether lipid metabolism_Homo sapiens_hsa005650.43845870
136Alcoholism_Homo sapiens_hsa050340.43404558
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42851897
138MAPK signaling pathway_Homo sapiens_hsa040100.41781732
139ABC transporters_Homo sapiens_hsa020100.41570391
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40734974
141mTOR signaling pathway_Homo sapiens_hsa041500.40655320
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39034129
143Long-term depression_Homo sapiens_hsa047300.38926940
144Mineral absorption_Homo sapiens_hsa049780.38865591
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38794363
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38652367
147VEGF signaling pathway_Homo sapiens_hsa043700.38575346
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38302173
149Hedgehog signaling pathway_Homo sapiens_hsa043400.36622575
150Axon guidance_Homo sapiens_hsa043600.35525715
151ErbB signaling pathway_Homo sapiens_hsa040120.32414996
152Other glycan degradation_Homo sapiens_hsa005110.32250255
153Type II diabetes mellitus_Homo sapiens_hsa049300.31943050
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.31890797
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.30429244
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.30286480
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29813396
158Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29275933
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27717825
160FoxO signaling pathway_Homo sapiens_hsa040680.26472222
161Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26382214
162Arachidonic acid metabolism_Homo sapiens_hsa005900.24228698
163Non-small cell lung cancer_Homo sapiens_hsa052230.23701866
164Fructose and mannose metabolism_Homo sapiens_hsa000510.22998610
165Phospholipase D signaling pathway_Homo sapiens_hsa040720.22931584
166Tight junction_Homo sapiens_hsa045300.22811722
167Prolactin signaling pathway_Homo sapiens_hsa049170.21865140
168Choline metabolism in cancer_Homo sapiens_hsa052310.21623883
169Huntingtons disease_Homo sapiens_hsa050160.21037573
170Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18686522
171Ras signaling pathway_Homo sapiens_hsa040140.17802619
172Endocytosis_Homo sapiens_hsa041440.16442049
173Protein export_Homo sapiens_hsa030600.15837524
174Peroxisome_Homo sapiens_hsa041460.15335148
175Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13256389
176Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12038628
177Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11958663
178Pancreatic cancer_Homo sapiens_hsa052120.10459390
179Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09190154

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