MEI4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.08821239
2regulation of meiosis I (GO:0060631)7.52300054
3positive regulation of antigen processing and presentation (GO:0002579)7.25320942
4male meiosis (GO:0007140)7.02324213
5regulation of T-helper 1 cell differentiation (GO:0045625)7.01098693
6DNA methylation involved in gamete generation (GO:0043046)6.45015213
7regulation of antigen processing and presentation (GO:0002577)6.12564214
8DNA strand renaturation (GO:0000733)6.04159484
9cellular protein complex localization (GO:0034629)5.97843611
10relaxation of smooth muscle (GO:0044557)5.92688831
11meiotic cell cycle (GO:0051321)5.82540472
12positive regulation of Cdc42 GTPase activity (GO:0043089)5.72491354
13dendritic cell chemotaxis (GO:0002407)5.65250205
14positive regulation of T-helper 1 type immune response (GO:0002827)5.60871087
15retinal cone cell development (GO:0046549)5.58863458
16regulation of DNA methylation (GO:0044030)5.41860559
17* synapsis (GO:0007129)5.32620461
18response to nitric oxide (GO:0071731)5.30191431
19positive regulation of interleukin-1 beta secretion (GO:0050718)5.29665628
20regulation of helicase activity (GO:0051095)5.28038769
21multicellular organism reproduction (GO:0032504)5.23301421
22regulation of female gonad development (GO:2000194)5.21410523
23positive regulation of histone H3-K4 methylation (GO:0051571)5.11180247
24aggressive behavior (GO:0002118)4.92964983
25positive regulation of T-helper cell differentiation (GO:0045624)4.91014850
26positive regulation of interleukin-1 secretion (GO:0050716)4.87796247
27positive regulation of granulocyte chemotaxis (GO:0071624)4.81808676
28positive regulation of glycoprotein biosynthetic process (GO:0010560)4.78130424
29single strand break repair (GO:0000012)4.74949086
30leukocyte tethering or rolling (GO:0050901)4.67694757
31acrosome reaction (GO:0007340)4.67505141
32positive regulation of neutrophil migration (GO:1902624)4.60381159
33positive regulation of neutrophil chemotaxis (GO:0090023)4.60381159
34cellular anion homeostasis (GO:0030002)4.59378164
35* female gamete generation (GO:0007292)4.57444596
36meiotic nuclear division (GO:0007126)4.56038838
37gene silencing by RNA (GO:0031047)4.54895291
38regulation of acrosome reaction (GO:0060046)4.54891286
39spermatid development (GO:0007286)4.54862949
40regulation of interleukin-1 beta secretion (GO:0050706)4.53243882
41DNA synthesis involved in DNA repair (GO:0000731)4.51539330
42* chromosome organization involved in meiosis (GO:0070192)4.50048870
43muscle atrophy (GO:0014889)4.45368317
44organic cation transport (GO:0015695)4.39992390
45male meiosis I (GO:0007141)4.36969467
46response to prostaglandin E (GO:0034695)4.36132040
47oocyte development (GO:0048599)4.33938516
48protein complex localization (GO:0031503)4.31718692
49dendritic cell migration (GO:0036336)4.30959492
50negative regulation of muscle hypertrophy (GO:0014741)4.26945662
51detection of bacterium (GO:0016045)4.25244039
52phosphate ion homeostasis (GO:0055062)4.19912112
53trivalent inorganic anion homeostasis (GO:0072506)4.19912112
54striated muscle atrophy (GO:0014891)4.18289874
55positive regulation of interleukin-1 beta production (GO:0032731)4.11861853
56regulation of T-helper 1 type immune response (GO:0002825)4.09929224
57detection of other organism (GO:0098543)4.08754727
58genitalia morphogenesis (GO:0035112)4.01488699
59regulation of neutrophil chemotaxis (GO:0090022)4.00747421
60regulation of neutrophil migration (GO:1902622)4.00747421
61imidazole-containing compound metabolic process (GO:0052803)3.97118069
62protein K6-linked ubiquitination (GO:0085020)3.95948683
63synaptonemal complex assembly (GO:0007130)3.91039405
64regulation of phosphoprotein phosphatase activity (GO:0043666)3.89776606
65positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.88125803
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86766041
67pyrimidine dimer repair (GO:0006290)3.83973749
68regulation of interleukin-1 secretion (GO:0050704)3.80205388
69response to gravity (GO:0009629)3.78457454
70positive regulation of meiosis (GO:0045836)3.77286636
71sympathetic nervous system development (GO:0048485)3.75372061
72skeletal muscle tissue regeneration (GO:0043403)3.75102053
73positive regulation of NF-kappaB import into nucleus (GO:0042346)3.73051437
74positive regulation of meiotic cell cycle (GO:0051446)3.71241056
75synaptonemal complex organization (GO:0070193)3.70965839
76positive regulation of interleukin-1 production (GO:0032732)3.67772575
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.66666532
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.66666532
79positive regulation of mitotic sister chromatid separation (GO:1901970)3.66666532
80binding of sperm to zona pellucida (GO:0007339)3.66117792
81meiotic chromosome segregation (GO:0045132)3.64494637
82histone exchange (GO:0043486)3.60118439
83fertilization (GO:0009566)3.59865684
84regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.57694969
85* germ cell development (GO:0007281)3.56275215
86positive regulation of catecholamine secretion (GO:0033605)3.55380317
87regulation of T-helper cell differentiation (GO:0045622)3.52844143
88skeletal muscle adaptation (GO:0043501)3.52407062
89reproduction (GO:0000003)3.52117267
90negative regulation of skeletal muscle tissue development (GO:0048642)3.50661553
91sperm motility (GO:0030317)3.49074013
92heterotypic cell-cell adhesion (GO:0034113)3.48966418
93lateral ventricle development (GO:0021670)3.47715269
94positive regulation of glycoprotein metabolic process (GO:1903020)3.46134661
95superoxide anion generation (GO:0042554)3.41849892
96protein K11-linked deubiquitination (GO:0035871)3.40370061
97regulation of activation of Janus kinase activity (GO:0010533)3.35484963
98single fertilization (GO:0007338)3.34361080
99negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.33770363
100negative regulation of hormone biosynthetic process (GO:0032353)3.32527439
101lipoxygenase pathway (GO:0019372)3.32454437
102regulation of granulocyte chemotaxis (GO:0071622)3.31057948
103positive regulation of actin filament depolymerization (GO:0030836)3.29796567
104negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.25977531
105centriole assembly (GO:0098534)3.25657071
106positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.23601990
107negative regulation of hormone metabolic process (GO:0032351)3.22412343
108regulation of meiosis (GO:0040020)3.21417705
109sperm-egg recognition (GO:0035036)3.21389176
110regulation of meiotic cell cycle (GO:0051445)3.18094198
111meiosis I (GO:0007127)3.14783710
112negative regulation of circadian rhythm (GO:0042754)3.12732286
113mast cell degranulation (GO:0043303)3.10903325
114mast cell activation involved in immune response (GO:0002279)3.10903325
115regulation of MHC class II biosynthetic process (GO:0045346)3.09780073
116dendritic cell differentiation (GO:0097028)3.09697343
117response to prostaglandin (GO:0034694)3.07774263
118positive regulation of interleukin-12 production (GO:0032735)3.07529667
119regulation of steroid hormone secretion (GO:2000831)3.05564856
120regulation of cellular senescence (GO:2000772)3.05410831
121positive regulation of histone methylation (GO:0031062)3.04980418
122* meiotic cell cycle process (GO:1903046)3.03174615
123regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.03126721
124calcium ion-dependent exocytosis (GO:0017156)3.01760970
125acrosome assembly (GO:0001675)3.01727297
126regulation of RIG-I signaling pathway (GO:0039535)3.01403494
127regulation of histone H3-K9 methylation (GO:0051570)2.97427747
128dopamine biosynthetic process (GO:0042416)2.96629660
129negative regulation of reproductive process (GO:2000242)2.92577634
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91982170
131paraxial mesoderm development (GO:0048339)2.91153672
132ovulation from ovarian follicle (GO:0001542)2.90696072
133lactate metabolic process (GO:0006089)2.88380080
134relaxation of muscle (GO:0090075)2.87895605
135regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.87180989
136xenobiotic catabolic process (GO:0042178)2.84271842
137glycine transport (GO:0015816)2.83901025
138TOR signaling (GO:0031929)2.83188650
139regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.81694698
140phosphatidylinositol dephosphorylation (GO:0046856)2.80663286
141positive regulation of urine volume (GO:0035810)2.79317052
142negative regulation of execution phase of apoptosis (GO:1900118)2.79004486
143cytokine secretion (GO:0050663)2.78818880
144phospholipid dephosphorylation (GO:0046839)2.78818562
145positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77437426
146sister chromatid cohesion (GO:0007062)2.77276326
147regulation of chromatin silencing (GO:0031935)2.76992028
148tryptophan catabolic process (GO:0006569)2.76983896
149indole-containing compound catabolic process (GO:0042436)2.76983896
150indolalkylamine catabolic process (GO:0046218)2.76983896
151centriole replication (GO:0007099)2.76870303
152kinetochore assembly (GO:0051382)2.76499492
153epithelial cilium movement (GO:0003351)2.74880487
154regulation of Cdc42 GTPase activity (GO:0043088)2.74728397
155regulation of steroid hormone biosynthetic process (GO:0090030)2.72297908
156* cellular process involved in reproduction in multicellular organism (GO:0022412)2.72163737
157primitive streak formation (GO:0090009)2.72051014
158kinetochore organization (GO:0051383)2.70087596
159negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.70016611
160synaptic vesicle maturation (GO:0016188)2.69697638
161positive regulation of gastrulation (GO:2000543)2.65869215
162nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.64862311
163cellular ketone body metabolic process (GO:0046950)2.61659591
164negative regulation of cell aging (GO:0090344)2.61090594
165* oogenesis (GO:0048477)2.60959171
166metanephric tubule development (GO:0072170)2.59554543
167metanephric nephron tubule development (GO:0072234)2.59554543
168collecting duct development (GO:0072044)2.59498963
169DNA methylation (GO:0006306)2.58896086
170DNA alkylation (GO:0006305)2.58896086
171amine biosynthetic process (GO:0009309)2.58830937
172cellular biogenic amine biosynthetic process (GO:0042401)2.58830937
173cell-cell recognition (GO:0009988)2.57457041
174mast cell activation (GO:0045576)2.57202795
175regulation of calcium ion-dependent exocytosis (GO:0017158)2.57126000
176dentate gyrus development (GO:0021542)2.56953196
177regulation of female receptivity (GO:0045924)2.56492909
178negative regulation of androgen receptor signaling pathway (GO:0060766)2.56173911
179gamma-aminobutyric acid signaling pathway (GO:0007214)2.55736143
180CENP-A containing nucleosome assembly (GO:0034080)2.54198027
181negative regulation of DNA-dependent DNA replication (GO:2000104)2.54151410
182regulation of histone H3-K4 methylation (GO:0051569)2.53190977
183attachment of spindle microtubules to kinetochore (GO:0008608)2.52877326
184somite rostral/caudal axis specification (GO:0032525)2.52814037
185cilium or flagellum-dependent cell motility (GO:0001539)2.52727996
186androgen biosynthetic process (GO:0006702)2.51445909
187negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.49003367
188regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.47807214
189regulation of nuclear cell cycle DNA replication (GO:0033262)2.43573836
190renal tubule development (GO:0061326)2.42868731
191cellular response to gamma radiation (GO:0071480)2.41503918
192chromatin remodeling at centromere (GO:0031055)2.41062304
193regulation of interleukin-1 beta production (GO:0032651)2.39960168
194left/right axis specification (GO:0070986)2.39514687
195regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.32987736
196regulation of dendritic cell antigen processing and presentation (GO:0002604)10.0353527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.11126519
2E2F7_22180533_ChIP-Seq_HELA_Human5.35647435
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.35087104
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.49161376
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.31074835
6PCGF2_27294783_Chip-Seq_ESCs_Mouse3.24537268
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01811485
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.80458417
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.78335437
10IGF1R_20145208_ChIP-Seq_DFB_Human2.70195763
11GBX2_23144817_ChIP-Seq_PC3_Human2.57330619
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56069087
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.39629930
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36113292
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.29376663
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26451729
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17401512
18ZNF274_21170338_ChIP-Seq_K562_Hela2.06548602
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03386135
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.02870562
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01149351
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90017600
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.88291189
24CBP_20019798_ChIP-Seq_JUKART_Human1.88291189
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.88026741
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.86524691
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.86214434
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85681835
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85681835
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85681835
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.85606463
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85447631
33VDR_22108803_ChIP-Seq_LS180_Human1.84533002
34NMYC_18555785_Chip-Seq_ESCs_Mouse1.82343226
35HTT_18923047_ChIP-ChIP_STHdh_Human1.75830749
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.75808411
37STAT3_18555785_Chip-Seq_ESCs_Mouse1.72861028
38RUNX1_27457419_Chip-Seq_LIVER_Mouse1.72213947
39E2F1_18555785_Chip-Seq_ESCs_Mouse1.72124809
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71933836
41P53_22387025_ChIP-Seq_ESCs_Mouse1.69129551
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68982540
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67956178
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67326752
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.66593708
46IRF1_19129219_ChIP-ChIP_H3396_Human1.66298104
47EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65975636
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60555780
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59174110
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.59145668
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58905293
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58741390
53OCT4_18555785_Chip-Seq_ESCs_Mouse1.58738517
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58667813
55BCAT_22108803_ChIP-Seq_LS180_Human1.58358518
56P300_19829295_ChIP-Seq_ESCs_Human1.57415711
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56697106
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.56639678
59ZFX_18555785_Chip-Seq_ESCs_Mouse1.56322217
60EZH2_22144423_ChIP-Seq_EOC_Human1.56053645
61P300_18555785_Chip-Seq_ESCs_Mouse1.54693317
62EWS_26573619_Chip-Seq_HEK293_Human1.54300220
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54257741
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.52512192
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52227118
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50528907
67RUNX2_22187159_ChIP-Seq_PCA_Human1.48951636
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.46437936
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45641435
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.43883276
71CTCF_18555785_Chip-Seq_ESCs_Mouse1.41929596
72PU1_27457419_Chip-Seq_LIVER_Mouse1.41753698
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.41425688
74ESRRB_18555785_Chip-Seq_ESCs_Mouse1.40973563
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40231064
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37063701
77RNF2_27304074_Chip-Seq_NSC_Mouse1.34399053
78SMAD1_18555785_Chip-Seq_ESCs_Mouse1.33501260
79CDX2_22108803_ChIP-Seq_LS180_Human1.33117812
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.32006448
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.29540163
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.29144621
83FUS_26573619_Chip-Seq_HEK293_Human1.28493160
84OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27986853
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27609700
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25518133
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.24587609
88TAF15_26573619_Chip-Seq_HEK293_Human1.24476410
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.23830588
90ERG_20517297_ChIP-Seq_VCAP_Human1.23562903
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22798814
92TP53_22573176_ChIP-Seq_HFKS_Human1.22355252
93NANOG_19829295_ChIP-Seq_ESCs_Human1.21808422
94SOX2_19829295_ChIP-Seq_ESCs_Human1.21808422
95TCF4_22108803_ChIP-Seq_LS180_Human1.20964162
96* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18876950
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18488692
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18488692
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16698392
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16663523
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16253734
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16175838
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15840431
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14399396
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12628108
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09741865
107CBP_21632823_ChIP-Seq_H3396_Human1.08899061
108ER_23166858_ChIP-Seq_MCF-7_Human1.07427397
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04114917
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03832372
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03640747
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03432339
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.02782952
114NANOG_20526341_ChIP-Seq_ESCs_Human1.02759256
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02492370
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02456863
117AHR_22903824_ChIP-Seq_MCF-7_Human1.01681767
118KDM2B_26808549_Chip-Seq_REH_Human1.00926977
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00347139
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.00199242
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.99988008
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99988008
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99599986
124ELK1_19687146_ChIP-ChIP_HELA_Human0.98827763
125STAT3_23295773_ChIP-Seq_U87_Human0.98733782
126OCT1_27270436_Chip-Seq_PROSTATE_Human0.98580409
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.98421103
128AR_25329375_ChIP-Seq_VCAP_Human0.98395654
129REST_21632747_ChIP-Seq_MESCs_Mouse0.97558335
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.97425974
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96656216
132SCL_19346495_ChIP-Seq_HPC-7_Human0.96321289
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95057236
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94750861
135TP53_16413492_ChIP-PET_HCT116_Human0.94649325
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94613711
137FOXM1_23109430_ChIP-Seq_U2OS_Human0.94129483
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93746899
139TBL1_22424771_ChIP-Seq_293T_Human0.93569294
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93291477
141AR_20517297_ChIP-Seq_VCAP_Human0.92772200
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91050475
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90933172
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89983601
145GF1B_26923725_Chip-Seq_HPCs_Mouse0.89905249
146HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88885627
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88577292
148DROSHA_22980978_ChIP-Seq_HELA_Human0.87929784
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.87294994
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.87077496
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.86778292
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86644693
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86258480
154NCOR_22424771_ChIP-Seq_293T_Human0.86134701
155TCF4_23295773_ChIP-Seq_U87_Human0.85601028
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.85431006
157SMAD4_21799915_ChIP-Seq_A2780_Human0.85356506
158TP53_18474530_ChIP-ChIP_U2OS_Human0.85167733
159NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84648735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.66990053
2MP0002876_abnormal_thyroid_physiology4.43002738
3MP0005410_abnormal_fertilization4.18334025
4MP0000685_abnormal_immune_system3.88631519
5MP0002139_abnormal_hepatobiliary_system3.36135190
6MP0010368_abnormal_lymphatic_system3.30292724
7MP0010234_abnormal_vibrissa_follicle3.06603326
8MP0001984_abnormal_olfaction2.89861005
9MP0006292_abnormal_olfactory_placode2.88083770
10MP0001835_abnormal_antigen_presentation2.85097455
11MP0008058_abnormal_DNA_repair2.54766983
12* MP0001929_abnormal_gametogenesis2.51732823
13MP0002735_abnormal_chemical_nociception2.44230394
14MP0000566_synostosis2.36925421
15MP0003693_abnormal_embryo_hatching2.21269446
16MP0005395_other_phenotype2.15919422
17MP0003111_abnormal_nucleus_morphology2.11131542
18MP0005360_urolithiasis2.09549701
19* MP0003698_abnormal_male_reproductive2.04789142
20MP0005645_abnormal_hypothalamus_physiol2.01553731
21MP0001873_stomach_inflammation2.01262902
22MP0005503_abnormal_tendon_morphology1.99295852
23MP0005646_abnormal_pituitary_gland1.93983645
24MP0000015_abnormal_ear_pigmentation1.93634111
25MP0001188_hyperpigmentation1.91566534
26MP0005671_abnormal_response_to1.90117647
27MP0008877_abnormal_DNA_methylation1.87421946
28MP0006072_abnormal_retinal_apoptosis1.82203945
29MP0010094_abnormal_chromosome_stability1.79085188
30MP0002272_abnormal_nervous_system1.79075610
31MP0009046_muscle_twitch1.76881833
32MP0001346_abnormal_lacrimal_gland1.75004679
33* MP0000653_abnormal_sex_gland1.73321807
34MP0009697_abnormal_copulation1.73204703
35MP0009333_abnormal_splenocyte_physiolog1.71860874
36MP0003763_abnormal_thymus_physiology1.70470712
37* MP0001145_abnormal_male_reproductive1.66653615
38MP0008004_abnormal_stomach_pH1.66648435
39MP0005423_abnormal_somatic_nervous1.62314375
40MP0002089_abnormal_postnatal_growth/wei1.60598152
41MP0002277_abnormal_respiratory_mucosa1.59339685
42MP0002161_abnormal_fertility/fecundity1.57905834
43MP0003252_abnormal_bile_duct1.57136144
44MP0005551_abnormal_eye_electrophysiolog1.52661283
45MP0008875_abnormal_xenobiotic_pharmacok1.52353640
46MP0002396_abnormal_hematopoietic_system1.52226116
47* MP0005647_abnormal_sex_gland1.51840940
48MP0009785_altered_susceptibility_to1.46580368
49MP0002148_abnormal_hypersensitivity_rea1.46120136
50MP0000569_abnormal_digit_pigmentation1.44847525
51MP0003941_abnormal_skin_development1.44580652
52MP0005187_abnormal_penis_morphology1.42746570
53MP0010386_abnormal_urinary_bladder1.42500261
54MP0003195_calcinosis1.41457086
55MP0002138_abnormal_hepatobiliary_system1.41280213
56MP0003699_abnormal_female_reproductive1.38288543
57MP0006054_spinal_hemorrhage1.38241331
58MP0003787_abnormal_imprinting1.36879910
59MP0002090_abnormal_vision1.36447352
60MP0003183_abnormal_peptide_metabolism1.34639673
61MP0008789_abnormal_olfactory_epithelium1.33008645
62MP0002095_abnormal_skin_pigmentation1.32668122
63MP0002234_abnormal_pharynx_morphology1.32234532
64MP0000372_irregular_coat_pigmentation1.31640908
65MP0005075_abnormal_melanosome_morpholog1.30262789
66MP0003136_yellow_coat_color1.29677218
67MP0001501_abnormal_sleep_pattern1.29037573
68MP0005085_abnormal_gallbladder_physiolo1.28422803
69MP0002102_abnormal_ear_morphology1.28390529
70MP0000631_abnormal_neuroendocrine_gland1.28370030
71* MP0002160_abnormal_reproductive_system1.27098977
72MP0001800_abnormal_humoral_immune1.26420571
73MP0005310_abnormal_salivary_gland1.25566558
74* MP0001119_abnormal_female_reproductive1.23227518
75MP0002254_reproductive_system_inflammat1.23007300
76MP0005174_abnormal_tail_pigmentation1.20283411
77MP0003077_abnormal_cell_cycle1.19831632
78MP0003315_abnormal_perineum_morphology1.18617755
79MP0003868_abnormal_feces_composition1.18357038
80MP0002638_abnormal_pupillary_reflex1.17487174
81MP0001485_abnormal_pinna_reflex1.16802972
82MP0009764_decreased_sensitivity_to1.16609341
83MP0005464_abnormal_platelet_physiology1.16011951
84MP0006276_abnormal_autonomic_nervous1.15994629
85MP0002452_abnormal_antigen_presenting1.14294225
86MP0009745_abnormal_behavioral_response1.14195700
87MP0004782_abnormal_surfactant_physiolog1.12748094
88MP0001664_abnormal_digestion1.11729445
89MP0010678_abnormal_skin_adnexa1.10719191
90MP0001819_abnormal_immune_cell1.09512905
91MP0002420_abnormal_adaptive_immunity1.09360783
92MP0009780_abnormal_chondrocyte_physiolo1.08968587
93MP0008007_abnormal_cellular_replicative1.08924925
94MP0005387_immune_system_phenotype1.08490442
95MP0001790_abnormal_immune_system1.08490442
96MP0006082_CNS_inflammation1.07757989
97MP0001348_abnormal_lacrimal_gland1.06607776
98MP0002723_abnormal_immune_serum1.06578077
99MP0003718_maternal_effect1.06208949
100* MP0005389_reproductive_system_phenotype1.04449642
101MP0005394_taste/olfaction_phenotype1.04442666
102MP0005499_abnormal_olfactory_system1.04442666
103MP0000013_abnormal_adipose_tissue1.03344168
104MP0002419_abnormal_innate_immunity1.02625796
105MP0005025_abnormal_response_to1.02559493
106MP0002249_abnormal_larynx_morphology1.02126947
107MP0003879_abnormal_hair_cell1.02015383
108MP0006035_abnormal_mitochondrial_morpho1.01793413
109MP0003121_genomic_imprinting1.00817496
110MP0003786_premature_aging1.00801078
111MP0000470_abnormal_stomach_morphology1.00262108
112MP0002837_dystrophic_cardiac_calcinosis1.00172409
113MP0000049_abnormal_middle_ear0.99709742
114MP0002398_abnormal_bone_marrow0.99658711
115MP0001944_abnormal_pancreas_morphology0.99057704
116MP0008995_early_reproductive_senescence0.97251262
117MP0002405_respiratory_system_inflammati0.96916577
118MP0005000_abnormal_immune_tolerance0.96374205
119MP0001186_pigmentation_phenotype0.96235166
120MP0001756_abnormal_urination0.96177029
121MP0002075_abnormal_coat/hair_pigmentati0.96050058
122MP0003880_abnormal_central_pattern0.95314313
123MP0001986_abnormal_taste_sensitivity0.94094641
124MP0004381_abnormal_hair_follicle0.93562604
125MP0002108_abnormal_muscle_morphology0.91707379
126MP0004084_abnormal_cardiac_muscle0.90705689
127MP0002557_abnormal_social/conspecific_i0.90704843
128MP0000716_abnormal_immune_system0.90503587
129MP0003890_abnormal_embryonic-extraembry0.89158999
130MP0004085_abnormal_heartbeat0.88850501
131MP0002064_seizures0.87033041
132MP0000371_diluted_coat_color0.86924391
133MP0002751_abnormal_autonomic_nervous0.86228180
134MP0000427_abnormal_hair_cycle0.86017510
135MP0001666_abnormal_nutrient_absorption0.84650964
136MP0003283_abnormal_digestive_organ0.84625280
137MP0002177_abnormal_outer_ear0.82762430
138MP0004043_abnormal_pH_regulation0.82151765
139MP0001919_abnormal_reproductive_system0.81895228
140MP0003635_abnormal_synaptic_transmissio0.80680988
141MP0004215_abnormal_myocardial_fiber0.80490370
142MP0002928_abnormal_bile_duct0.80445415
143MP0001879_abnormal_lymphatic_vessel0.80176946
144MP0002429_abnormal_blood_cell0.76509062
145* MP0002210_abnormal_sex_determination0.76112660
146MP0002877_abnormal_melanocyte_morpholog0.75894518
147MP0001486_abnormal_startle_reflex0.75419301
148MP0005409_darkened_coat_color0.73368386
149MP0002572_abnormal_emotion/affect_behav0.73303915
150MP0001502_abnormal_circadian_rhythm0.72495964
151MP0003045_fibrosis0.71667113
152MP0002132_abnormal_respiratory_system0.70811086
153MP0003633_abnormal_nervous_system0.69421933
154MP0003119_abnormal_digestive_system0.69178062
155MP0005253_abnormal_eye_physiology0.68349836
156MP0005220_abnormal_exocrine_pancreas0.67719972
157MP0003123_paternal_imprinting0.66818358
158MP0001968_abnormal_touch/_nociception0.65518305
159MP0001905_abnormal_dopamine_level0.64408049
160MP0010329_abnormal_lipoprotein_level0.63615190
161MP0002229_neurodegeneration0.63195166
162MP0002067_abnormal_sensory_capabilities0.61622385
163MP0002233_abnormal_nose_morphology0.59797589
164MP0000230_abnormal_systemic_arterial0.57256269
165MP0002063_abnormal_learning/memory/cond0.57168790

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.43561738
2Chromsome breakage (HP:0040012)5.07462417
3Osteomalacia (HP:0002749)4.55894892
4Gonadal dysgenesis (HP:0000133)4.23439556
5Supernumerary spleens (HP:0009799)4.12228076
6Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.92314369
7Sex reversal (HP:0012245)3.91726477
8Abnormal sex determination (HP:0012244)3.91726477
9Retrobulbar optic neuritis (HP:0100654)3.81509533
10Optic neuritis (HP:0100653)3.81509533
11Horizontal nystagmus (HP:0000666)3.74417672
12Keratoconjunctivitis (HP:0001096)3.69717961
13Abnormality of the phalanges of the 5th finger (HP:0004213)3.66056323
14Increased IgE level (HP:0003212)3.55939763
15Orchitis (HP:0100796)3.52945952
16Facial hemangioma (HP:0000329)3.51049792
17Type 2 muscle fiber atrophy (HP:0003554)3.49609895
18Proximal tubulopathy (HP:0000114)3.44990336
19Gonadotropin excess (HP:0000837)3.40830396
20Infertility (HP:0000789)3.30005468
21Sensory axonal neuropathy (HP:0003390)3.25276558
22Abnormality of the preputium (HP:0100587)3.22797666
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.22636306
24Atonic seizures (HP:0010819)3.19321566
25Chronic mucocutaneous candidiasis (HP:0002728)3.18756079
26Recurrent cutaneous fungal infections (HP:0011370)3.18756079
27Hypoplasia of the uterus (HP:0000013)3.17799176
28Muscle fiber atrophy (HP:0100295)3.15212535
29Dysdiadochokinesis (HP:0002075)3.14181107
30Myositis (HP:0100614)3.13671685
31Aplasia/Hypoplasia of the uvula (HP:0010293)3.10682876
32Enlarged penis (HP:0000040)3.07984193
33Male pseudohermaphroditism (HP:0000037)3.05190413
34Congenital sensorineural hearing impairment (HP:0008527)3.03426177
35Abdominal situs inversus (HP:0003363)3.02641307
36Abnormality of abdominal situs (HP:0011620)3.02641307
37Type I diabetes mellitus (HP:0100651)2.94531232
38Oligodactyly (hands) (HP:0001180)2.93903836
39Syringomyelia (HP:0003396)2.90167032
40Spinal cord lesions (HP:0100561)2.90167032
41Gaze-evoked nystagmus (HP:0000640)2.88319110
42Eczematoid dermatitis (HP:0000976)2.86763406
43Median cleft lip (HP:0000161)2.85258343
44Abnormal biliary tract physiology (HP:0012439)2.82768008
45Bile duct proliferation (HP:0001408)2.82768008
46Hypoplasia of the fovea (HP:0007750)2.79924100
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.79924100
48Keratoconjunctivitis sicca (HP:0001097)2.78576387
49Prostate neoplasm (HP:0100787)2.69329317
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.67996677
51Short tibia (HP:0005736)2.67304295
52Abnormal spermatogenesis (HP:0008669)2.66534690
53Abnormality of the renal collecting system (HP:0004742)2.66035206
54Mediastinal lymphadenopathy (HP:0100721)2.65389825
55Intrahepatic cholestasis (HP:0001406)2.64051204
56Aplasia/hypoplasia of the uterus (HP:0008684)2.63707528
57Meckel diverticulum (HP:0002245)2.60580500
58Neoplasm of the oral cavity (HP:0100649)2.59405516
59Postural tremor (HP:0002174)2.58360347
60Duplicated collecting system (HP:0000081)2.53676987
61Asplenia (HP:0001746)2.53112539
62Pancreatic cysts (HP:0001737)2.52420693
63Abnormality of the ileum (HP:0001549)2.51145339
64Recurrent abscess formation (HP:0002722)2.50390295
65Clubbing of toes (HP:0100760)2.47953672
66Meningitis (HP:0001287)2.44669047
67Chronic obstructive pulmonary disease (HP:0006510)2.44343591
68Obstructive lung disease (HP:0006536)2.44343591
69Gangrene (HP:0100758)2.43554334
70Birth length less than 3rd percentile (HP:0003561)2.42739048
71Abnormality of the labia minora (HP:0012880)2.42714640
72Hypokinesia (HP:0002375)2.41149491
73Symphalangism affecting the phalanges of the hand (HP:0009773)2.37239647
74Small hand (HP:0200055)2.37063798
75Abnormality of chromosome stability (HP:0003220)2.34108056
76Myokymia (HP:0002411)2.33619113
77Increased IgM level (HP:0003496)2.31095129
78Recurrent fungal infections (HP:0002841)2.29100929
79Resting tremor (HP:0002322)2.28585283
80Xerostomia (HP:0000217)2.26682861
81Abnormal ciliary motility (HP:0012262)2.26479239
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.24634427
83Capillary hemangiomas (HP:0005306)2.22308253
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.21794843
85Tongue fasciculations (HP:0001308)2.19600928
86Absent speech (HP:0001344)2.18979405
87Supernumerary nipples (HP:0002558)2.18377214
88Chronic hepatic failure (HP:0100626)2.16789745
89Gingivitis (HP:0000230)2.16041710
90Hypophosphatemic rickets (HP:0004912)2.15155470
91Enlarged kidneys (HP:0000105)2.13990704
92Amniotic constriction ring (HP:0009775)2.13551674
93Abnormality of placental membranes (HP:0011409)2.13551674
94Decreased central vision (HP:0007663)2.13183734
95Spontaneous abortion (HP:0005268)2.10326012
96Optic nerve hypoplasia (HP:0000609)2.10125437
97True hermaphroditism (HP:0010459)2.09747750
98Intestinal atresia (HP:0011100)2.09605160
99Intellectual disability, mild (HP:0001256)2.08441998
100Fair hair (HP:0002286)2.07546991
101Abnormal rod and cone electroretinograms (HP:0008323)2.06821875
102Action tremor (HP:0002345)2.05875354
103Recurrent bacterial skin infections (HP:0005406)2.05451579
104Abnormality of the prostate (HP:0008775)2.05327434
105Encephalitis (HP:0002383)2.04879102
106Pancreatic fibrosis (HP:0100732)2.04184719
107Renal cortical cysts (HP:0000803)2.03675246
108Ketosis (HP:0001946)2.03530629
109Septo-optic dysplasia (HP:0100842)2.03508116
110Aplasia/Hypoplasia of the tongue (HP:0010295)2.03053024
111Abnormality of vitamin metabolism (HP:0100508)2.02200875
112Testicular neoplasm (HP:0010788)2.02162058
113Glycosuria (HP:0003076)2.02144814
114Abnormality of urine glucose concentration (HP:0011016)2.02144814
115Abnormality of the renal cortex (HP:0011035)2.01877780
116Recurrent pneumonia (HP:0006532)2.01680330
117Renal Fanconi syndrome (HP:0001994)1.99883492
118Abnormality of the fovea (HP:0000493)1.99737960
119Short 5th finger (HP:0009237)1.98348681
120Ectopic kidney (HP:0000086)1.98185666
121Myelodysplasia (HP:0002863)1.97818003
122Lower limb hyperreflexia (HP:0002395)1.96122068
123Febrile seizures (HP:0002373)1.96018793
124Small intestinal stenosis (HP:0012848)1.95412182
125Duodenal stenosis (HP:0100867)1.95412182
126Abnormal respiratory motile cilium physiology (HP:0012261)1.94387224
127Limb hypertonia (HP:0002509)1.93487998
128Agammaglobulinemia (HP:0004432)1.92802751
129Intention tremor (HP:0002080)1.92535851
130Hypoglycemic coma (HP:0001325)1.90813071
131Prolonged neonatal jaundice (HP:0006579)1.89709062
132Recurrent skin infections (HP:0001581)1.89704126
133Aplasia/Hypoplasia of the macula (HP:0008059)1.89278451
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.88388622
135Papillary thyroid carcinoma (HP:0002895)1.87061710
136Abnormality of macular pigmentation (HP:0008002)1.86982708
137Methylmalonic acidemia (HP:0002912)1.86544488
138Ketoacidosis (HP:0001993)1.86215518
139Volvulus (HP:0002580)1.86009693
140Absence seizures (HP:0002121)1.85297064
141Generalized hypopigmentation of hair (HP:0011358)1.85198037
142Oligohydramnios (HP:0001562)1.84870655
143Long clavicles (HP:0000890)1.84825800
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84438093
145Abnormal protein N-linked glycosylation (HP:0012347)1.84438093
146Abnormal protein glycosylation (HP:0012346)1.84438093
147Abnormal glycosylation (HP:0012345)1.84438093
148Synostosis involving bones of the hand (HP:0004278)1.84282937
149Hyperglycinemia (HP:0002154)1.84154780
150Abnormality of midbrain morphology (HP:0002418)1.83572615
151Molar tooth sign on MRI (HP:0002419)1.83572615
152Keratitis (HP:0000491)1.82953349
153Stomach cancer (HP:0012126)1.82347546
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82285346
155Abnormality of vitamin B metabolism (HP:0004340)1.82183497
156Abnormality of male internal genitalia (HP:0000022)1.81955606
157Upper limb muscle weakness (HP:0003484)1.81851343
158Abnormal urine phosphate concentration (HP:0012599)1.81611779
159Broad nasal tip (HP:0000455)1.81563288
160Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81380530
161Hypothermia (HP:0002045)1.79392841
162Anterior segment dysgenesis (HP:0007700)1.78908398
163Abnormality of incisor morphology (HP:0011063)1.78488335
164Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78195329
165Large for gestational age (HP:0001520)1.77859648
166Hypergammaglobulinemia (HP:0010702)1.77369805
167Rickets (HP:0002748)1.77032834
168Attenuation of retinal blood vessels (HP:0007843)1.76440215
169Double outlet right ventricle (HP:0001719)1.76374581
170Congenital malformation of the right heart (HP:0011723)1.76374581
171Male infertility (HP:0003251)1.75420493
172Sepsis (HP:0100806)1.74879381
173Medulloblastoma (HP:0002885)1.73691187
174Dysmetric saccades (HP:0000641)1.71299661
175Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70524634
176Premature loss of primary teeth (HP:0006323)1.70117364
177Increased corneal curvature (HP:0100692)1.69880774
178Keratoconus (HP:0000563)1.69880774
179Increased circulating renin level (HP:0000848)1.69597604
180Steatorrhea (HP:0002570)1.69238424
181Bone marrow hypocellularity (HP:0005528)1.68997164
182Hyperaldosteronism (HP:0000859)1.68941354
183Absent/shortened dynein arms (HP:0200106)1.68236573
184Dynein arm defect of respiratory motile cilia (HP:0012255)1.68236573
185Cheilitis (HP:0100825)1.68175283
186Absent thumb (HP:0009777)1.67539061
187Lip pit (HP:0100267)1.67209683
188Fetal akinesia sequence (HP:0001989)1.66191417
189Type I transferrin isoform profile (HP:0003642)1.65723744
190Fibular aplasia (HP:0002990)1.65338181
191Azoospermia (HP:0000027)1.64748858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.67785740
2MAP3K93.62380249
3DYRK33.47978498
4IRAK43.34322456
5MAP3K133.11599017
6TXK3.07470337
7ZAK3.02100473
8ARAF2.91242407
9SRPK12.89367325
10MAP3K142.68560009
11MARK32.54675673
12MAP2K72.44449616
13BMPR22.40991136
14MET2.31474846
15PINK12.28194458
16IRAK32.10711571
17PLK42.09531988
18TNK22.05756597
19SIK32.03846549
20INSRR1.96949637
21CASK1.96302328
22DYRK1B1.90261122
23PNCK1.87865015
24STK391.81026384
25CDK191.80015088
26VRK11.78079219
27MAP3K61.72440959
28OXSR11.71881938
29STK38L1.68491392
30ERBB31.60604901
31NTRK31.51038322
32MYLK1.49263646
33IRAK21.48508541
34CDK81.47668603
35CDC71.41471429
36STK161.39741831
37MKNK21.37529033
38NEK91.37016087
39TLK11.36941162
40STK31.36005212
41MUSK1.33655645
42EIF2AK21.33016146
43ADRBK21.30516940
44CSNK1G11.28052002
45IKBKE1.27833549
46MKNK11.27014140
47CDK31.26293548
48TIE11.26239074
49CSNK1G31.24986409
50EPHA31.21996912
51TTK1.20736726
52EIF2AK11.19506454
53DYRK1A1.19065649
54PLK21.18910267
55TEC1.17170692
56MST41.17088314
57MAP3K121.16044913
58ACVR1B1.13518835
59MOS1.12194032
60WNK31.10761299
61SYK1.10571921
62CSNK1G21.10495412
63PIK3CG1.08620186
64SGK21.08537348
65NEK61.06280107
66NEK21.04280335
67BMPR1B1.03704371
68CSNK1A1L1.03266809
69NUAK11.00628559
70AKT30.99922252
71STK240.98594717
72PLK30.96728077
73RPS6KA50.95202643
74BRAF0.94813571
75RAF10.94803496
76CHUK0.94693249
77FER0.92159084
78STK380.90735541
79IKBKB0.90571771
80ATR0.90423546
81PRKG10.85956225
82TAOK30.84696829
83NLK0.83338659
84PLK10.82666283
85BTK0.80446286
86PIM20.79859019
87YES10.77061235
88BUB10.76164981
89PRPF4B0.74986734
90STK100.74967873
91TSSK60.74172685
92EIF2AK30.72646197
93LATS10.72059623
94GRK70.71805581
95CLK10.71537742
96WNK10.70634702
97MAPK130.67702231
98BCR0.66480603
99LYN0.66249576
100MAP3K40.64599778
101PRKCQ0.61803499
102TNIK0.61558540
103PRKCI0.61364071
104IRAK10.61118914
105MAPK150.60528009
106MELK0.60476477
107FGFR30.60288820
108MAP2K60.56380514
109KIT0.55999948
110ERBB40.55799951
111PRKG20.55726072
112GRK10.55688469
113PRKCD0.55546482
114KSR20.54793555
115CDK70.53838154
116DYRK20.53186018
117BRSK10.52712405
118CSNK1D0.52594517
119ATM0.52197204
120TRPM70.51419574
121FGFR20.49237822
122ILK0.49065815
123STK40.48252742
124PTK2B0.47558427
125AURKB0.45411506
126CAMK2A0.45129665
127CHEK20.45100272
128CSNK1E0.44714505
129PTK20.44626177
130MAP3K10.42744673
131WNK40.41202937
132PRKCE0.40407698
133KSR10.40164871
134CDK50.39914833
135EGFR0.39671821
136TESK10.39182518
137CDK90.38610951
138DAPK20.37792464
139JAK30.37307849
140DAPK10.37062661
141PASK0.36249789
142RPS6KB10.35625822
143CSNK2A10.35110497
144MATK0.34551458
145PIM10.34230857
146AURKA0.33061591
147SGK30.32498532
148MAP3K50.32411903
149PRKACA0.31612373
150CSNK1A10.31377169
151NTRK20.30931267
152NEK10.30470894
153CDK10.30126871
154PRKACB0.29171981
155PAK30.29165912
156CHEK10.28137088
157GSK3A0.25506393

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.97092162
2DNA replication_Homo sapiens_hsa030302.65112093
3Homologous recombination_Homo sapiens_hsa034402.57949459
4Gap junction_Homo sapiens_hsa045402.43788062
5Fanconi anemia pathway_Homo sapiens_hsa034602.39934950
6Primary immunodeficiency_Homo sapiens_hsa053402.38736047
7Mismatch repair_Homo sapiens_hsa034302.38143431
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.32986136
9Histidine metabolism_Homo sapiens_hsa003402.25699786
10Nitrogen metabolism_Homo sapiens_hsa009102.23135435
11Linoleic acid metabolism_Homo sapiens_hsa005912.22206135
12Circadian rhythm_Homo sapiens_hsa047102.18447433
13Propanoate metabolism_Homo sapiens_hsa006402.17124222
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.14438880
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12531654
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91082772
17Base excision repair_Homo sapiens_hsa034101.87409203
18Oocyte meiosis_Homo sapiens_hsa041141.85738748
19RNA polymerase_Homo sapiens_hsa030201.84840194
20Basal transcription factors_Homo sapiens_hsa030221.84345873
21Caffeine metabolism_Homo sapiens_hsa002321.83449764
22Arachidonic acid metabolism_Homo sapiens_hsa005901.78316311
23Long-term depression_Homo sapiens_hsa047301.77993263
24Cell cycle_Homo sapiens_hsa041101.76794247
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74919236
26Dorso-ventral axis formation_Homo sapiens_hsa043201.74461828
27Butanoate metabolism_Homo sapiens_hsa006501.72489951
28Vitamin B6 metabolism_Homo sapiens_hsa007501.66867569
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61419329
30Proteasome_Homo sapiens_hsa030501.58656102
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58123808
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.57890361
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56158960
34Non-homologous end-joining_Homo sapiens_hsa034501.55479972
35p53 signaling pathway_Homo sapiens_hsa041151.54611759
36Pyrimidine metabolism_Homo sapiens_hsa002401.52937594
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48808247
38Olfactory transduction_Homo sapiens_hsa047401.47221052
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45682519
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44762186
41RNA degradation_Homo sapiens_hsa030181.43731540
42Folate biosynthesis_Homo sapiens_hsa007901.43187430
43Phototransduction_Homo sapiens_hsa047441.42039066
44Ovarian steroidogenesis_Homo sapiens_hsa049131.41831705
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32930428
46Circadian entrainment_Homo sapiens_hsa047131.30812276
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.28067201
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27465629
49Allograft rejection_Homo sapiens_hsa053301.27022031
50Purine metabolism_Homo sapiens_hsa002301.25508892
51GABAergic synapse_Homo sapiens_hsa047271.22305806
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19610153
53Antigen processing and presentation_Homo sapiens_hsa046121.18792722
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18589704
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18115286
56Nucleotide excision repair_Homo sapiens_hsa034201.16578098
57Vitamin digestion and absorption_Homo sapiens_hsa049771.14777033
58Spliceosome_Homo sapiens_hsa030401.14718811
59Ether lipid metabolism_Homo sapiens_hsa005651.13557217
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.13383918
61Tryptophan metabolism_Homo sapiens_hsa003801.11198720
62Arginine biosynthesis_Homo sapiens_hsa002201.09450820
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07433611
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04755716
65Measles_Homo sapiens_hsa051621.04236204
66Fatty acid elongation_Homo sapiens_hsa000621.03851876
67Selenocompound metabolism_Homo sapiens_hsa004501.02907501
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02759434
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02485988
70Glutathione metabolism_Homo sapiens_hsa004801.00806199
71Morphine addiction_Homo sapiens_hsa050320.99942431
72One carbon pool by folate_Homo sapiens_hsa006700.98063164
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97735138
74Chemical carcinogenesis_Homo sapiens_hsa052040.94028177
75Graft-versus-host disease_Homo sapiens_hsa053320.93538307
76Asthma_Homo sapiens_hsa053100.93424097
77Autoimmune thyroid disease_Homo sapiens_hsa053200.93206306
78Other glycan degradation_Homo sapiens_hsa005110.90058137
79Retinol metabolism_Homo sapiens_hsa008300.88874588
80Herpes simplex infection_Homo sapiens_hsa051680.88449598
81Protein export_Homo sapiens_hsa030600.88427615
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.88235971
83Leishmaniasis_Homo sapiens_hsa051400.87258016
84Peroxisome_Homo sapiens_hsa041460.86179692
85RNA transport_Homo sapiens_hsa030130.85968125
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85644956
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84715747
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84069655
89Insulin secretion_Homo sapiens_hsa049110.84035388
90Pyruvate metabolism_Homo sapiens_hsa006200.83988347
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83312954
92Rheumatoid arthritis_Homo sapiens_hsa053230.80611587
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78792620
94Hematopoietic cell lineage_Homo sapiens_hsa046400.76317749
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.74894056
96Nicotine addiction_Homo sapiens_hsa050330.71956370
97Renin secretion_Homo sapiens_hsa049240.71470708
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71279589
99Glutamatergic synapse_Homo sapiens_hsa047240.70690980
100Regulation of autophagy_Homo sapiens_hsa041400.70636513
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69802595
102Fatty acid metabolism_Homo sapiens_hsa012120.69580420
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68467609
104Chemokine signaling pathway_Homo sapiens_hsa040620.68130390
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.67674758
106Fat digestion and absorption_Homo sapiens_hsa049750.67565749
107Fatty acid degradation_Homo sapiens_hsa000710.67468730
108Synaptic vesicle cycle_Homo sapiens_hsa047210.67403950
109Salivary secretion_Homo sapiens_hsa049700.67165844
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.66240343
111Pentose phosphate pathway_Homo sapiens_hsa000300.65123330
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63974011
113Metabolic pathways_Homo sapiens_hsa011000.63356514
114Ribosome_Homo sapiens_hsa030100.62816727
115mRNA surveillance pathway_Homo sapiens_hsa030150.62692411
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61998651
117Pancreatic secretion_Homo sapiens_hsa049720.61555381
118Long-term potentiation_Homo sapiens_hsa047200.60312163
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60247671
120Calcium signaling pathway_Homo sapiens_hsa040200.60219888
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58564376
122Phenylalanine metabolism_Homo sapiens_hsa003600.58458417
123Type I diabetes mellitus_Homo sapiens_hsa049400.57315932
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56451451
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54798635
126N-Glycan biosynthesis_Homo sapiens_hsa005100.53766810
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53087351
128Apoptosis_Homo sapiens_hsa042100.52372386
129ABC transporters_Homo sapiens_hsa020100.52102665
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51595846
131Epstein-Barr virus infection_Homo sapiens_hsa051690.50215191
132Tuberculosis_Homo sapiens_hsa051520.49988536
133Sphingolipid metabolism_Homo sapiens_hsa006000.49425500
134Influenza A_Homo sapiens_hsa051640.49240694
135Legionellosis_Homo sapiens_hsa051340.49095849
136Collecting duct acid secretion_Homo sapiens_hsa049660.48498322
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47921297
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47429527
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47425621
140Oxidative phosphorylation_Homo sapiens_hsa001900.47295643
141Serotonergic synapse_Homo sapiens_hsa047260.47050616
142Phagosome_Homo sapiens_hsa041450.46989527
143Hedgehog signaling pathway_Homo sapiens_hsa043400.45474717
144TGF-beta signaling pathway_Homo sapiens_hsa043500.45218270
145FoxO signaling pathway_Homo sapiens_hsa040680.44329943
146Amphetamine addiction_Homo sapiens_hsa050310.44264865
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44162372
148beta-Alanine metabolism_Homo sapiens_hsa004100.43978909
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.42567833
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41817146
151Inositol phosphate metabolism_Homo sapiens_hsa005620.41548852
152Taste transduction_Homo sapiens_hsa047420.40384007
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37065673
154Osteoclast differentiation_Homo sapiens_hsa043800.35382011
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34148545
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31405843
157Viral carcinogenesis_Homo sapiens_hsa052030.29151908
158Hepatitis B_Homo sapiens_hsa051610.28895094
159HTLV-I infection_Homo sapiens_hsa051660.27192787
160TNF signaling pathway_Homo sapiens_hsa046680.26848010
161Ras signaling pathway_Homo sapiens_hsa040140.24733716
162Colorectal cancer_Homo sapiens_hsa052100.23995888

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