MEIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.71511388
2motile cilium assembly (GO:0044458)9.54263300
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.43956402
4spermatid development (GO:0007286)9.01695119
5piRNA metabolic process (GO:0034587)8.45908872
6male meiosis (GO:0007140)8.36427444
7synaptonemal complex organization (GO:0070193)7.72905670
8single fertilization (GO:0007338)7.57908246
9regulation of cilium movement (GO:0003352)7.49903331
10synaptonemal complex assembly (GO:0007130)7.47909013
11sperm capacitation (GO:0048240)6.74897834
12fertilization (GO:0009566)6.34448739
13negative regulation of inclusion body assembly (GO:0090084)6.10251984
14ventricular system development (GO:0021591)6.05833520
15* spermatogenesis (GO:0007283)5.76542558
16* male gamete generation (GO:0048232)5.74337445
17spermatid nucleus differentiation (GO:0007289)5.68794044
18DNA methylation involved in gamete generation (GO:0043046)5.49663852
19* gamete generation (GO:0007276)5.28702302
20chromosome organization involved in meiosis (GO:0070192)5.21487430
21microtubule depolymerization (GO:0007019)5.20095642
22male meiosis I (GO:0007141)5.13866346
23cellular process involved in reproduction in multicellular organism (GO:0022412)5.08682595
24germ cell development (GO:0007281)5.07353566
25regulation of inclusion body assembly (GO:0090083)5.05055847
26organic cation transport (GO:0015695)4.96551442
27cell recognition (GO:0008037)4.96367989
28calcium ion-dependent exocytosis (GO:0017156)4.96214744
29meiotic nuclear division (GO:0007126)4.67707354
30microtubule severing (GO:0051013)4.62571543
31behavioral response to ethanol (GO:0048149)4.60273758
32regulation of microtubule-based movement (GO:0060632)4.44495676
33axoneme assembly (GO:0035082)4.36182403
34seminiferous tubule development (GO:0072520)4.23442274
35intraciliary transport (GO:0042073)4.20817711
36* multicellular organismal reproductive process (GO:0048609)4.15006653
37glycerol ether metabolic process (GO:0006662)4.10317483
38monoubiquitinated protein deubiquitination (GO:0035520)4.10115735
39meiosis I (GO:0007127)4.07342961
40protein localization to cilium (GO:0061512)4.03452895
41short-term memory (GO:0007614)4.02742709
42GTP biosynthetic process (GO:0006183)4.01825597
43nucleoside diphosphate phosphorylation (GO:0006165)4.00441751
44protein neddylation (GO:0045116)3.94529056
45meiotic cell cycle (GO:0051321)3.90174076
46left/right pattern formation (GO:0060972)3.87837714
47chaperone-mediated protein complex assembly (GO:0051131)3.84080515
48genitalia morphogenesis (GO:0035112)3.83072047
49ether metabolic process (GO:0018904)3.79520746
50protein K11-linked deubiquitination (GO:0035871)3.71232824
51behavioral response to nicotine (GO:0035095)3.70285078
52photoreceptor cell maintenance (GO:0045494)3.65170187
53cilium organization (GO:0044782)3.64484584
54single strand break repair (GO:0000012)3.64204523
55sexual reproduction (GO:0019953)3.63312008
56resolution of meiotic recombination intermediates (GO:0000712)3.60507771
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58790994
58UTP biosynthetic process (GO:0006228)3.58745417
59neural tube formation (GO:0001841)3.57555026
60regulation of penile erection (GO:0060405)3.54590243
61nonmotile primary cilium assembly (GO:0035058)3.53429125
62protein polyglutamylation (GO:0018095)3.52680915
63microtubule-based movement (GO:0007018)3.48754387
64positive regulation of protein homooligomerization (GO:0032464)3.48643090
65cilium assembly (GO:0042384)3.46957905
66cellular component assembly involved in morphogenesis (GO:0010927)3.36795795
67multicellular organismal development (GO:0007275)3.36337672
68centriole replication (GO:0007099)3.33313243
69centriole assembly (GO:0098534)3.32713061
70cilium morphogenesis (GO:0060271)3.32130595
71UTP metabolic process (GO:0046051)3.25417142
72activated T cell proliferation (GO:0050798)3.24567297
73regulation of response to tumor cell (GO:0002834)3.19657397
74positive regulation of response to tumor cell (GO:0002836)3.19657397
75positive regulation of immune response to tumor cell (GO:0002839)3.19657397
76regulation of immune response to tumor cell (GO:0002837)3.19657397
77lactate metabolic process (GO:0006089)3.19051999
78kynurenine metabolic process (GO:0070189)3.10428398
79organelle disassembly (GO:1903008)3.09820895
80synapsis (GO:0007129)3.09801217
81chromosome condensation (GO:0030261)3.08407077
82base-excision repair, AP site formation (GO:0006285)3.04466901
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99667254
84alditol metabolic process (GO:0019400)2.99380166
85polyol catabolic process (GO:0046174)2.97337585
86pseudouridine synthesis (GO:0001522)2.96133896
87reciprocal meiotic recombination (GO:0007131)2.94912375
88reciprocal DNA recombination (GO:0035825)2.94912375
89protein refolding (GO:0042026)2.94470080
90gene silencing by RNA (GO:0031047)2.94299510
91replication fork processing (GO:0031297)2.93256797
92DNA packaging (GO:0006323)2.89528440
93meiotic cell cycle process (GO:1903046)2.89458033
94regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.87921818
95left/right axis specification (GO:0070986)2.86955085
96retinal cone cell development (GO:0046549)2.86368420
97positive regulation of mitochondrial fission (GO:0090141)2.83865653
98pyrimidine nucleobase catabolic process (GO:0006208)2.83506070
99sequestering of actin monomers (GO:0042989)2.82356530
100glycolytic process (GO:0006096)2.81901349
101tRNA modification (GO:0006400)2.81465797
102negative regulation of organelle assembly (GO:1902116)2.81175124
103fucose catabolic process (GO:0019317)2.80450258
104L-fucose metabolic process (GO:0042354)2.80450258
105L-fucose catabolic process (GO:0042355)2.80450258
106peptidyl-histidine modification (GO:0018202)2.80317406
107aldehyde catabolic process (GO:0046185)2.79461841
108guanosine-containing compound biosynthetic process (GO:1901070)2.78985332
109DNA double-strand break processing (GO:0000729)2.78296396
110carnitine transport (GO:0015879)2.77002419
111amino-acid betaine transport (GO:0015838)2.77002419
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.75735651
113NADH dehydrogenase complex assembly (GO:0010257)2.75735651
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75735651
115protein complex biogenesis (GO:0070271)2.74381955
116histone H2A acetylation (GO:0043968)2.74133949
117indole-containing compound catabolic process (GO:0042436)2.72918055
118indolalkylamine catabolic process (GO:0046218)2.72918055
119tryptophan catabolic process (GO:0006569)2.72918055
120microtubule polymerization or depolymerization (GO:0031109)2.71575694
121carnitine transmembrane transport (GO:1902603)2.71349677
122glycerol metabolic process (GO:0006071)2.70857877
123microtubule bundle formation (GO:0001578)2.70525419
124chromatin remodeling at centromere (GO:0031055)2.70379221
125regulation of centriole replication (GO:0046599)2.69877971
126limb bud formation (GO:0060174)2.68744234
127regulation of collateral sprouting (GO:0048670)2.68742938
128ribonucleoprotein complex disassembly (GO:0032988)2.67525445
129mitochondrial respiratory chain complex assembly (GO:0033108)2.63242924
130CTP metabolic process (GO:0046036)2.60403234
131CTP biosynthetic process (GO:0006241)2.60403234
132tRNA processing (GO:0008033)2.59462319
133dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.59076982
134nucleus organization (GO:0006997)2.57434319
135response to xenobiotic stimulus (GO:0009410)2.57429249
136meiotic chromosome segregation (GO:0045132)2.54238412
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54061548
138anterograde synaptic vesicle transport (GO:0048490)2.53838010
139regulation of meiosis I (GO:0060631)2.53826326
140regulation of spindle checkpoint (GO:0090231)2.52789085
141somite development (GO:0061053)2.51778196
142histone H3-K9 methylation (GO:0051567)2.49885367
143negative regulation of T cell differentiation in thymus (GO:0033085)2.49017071
144indolalkylamine metabolic process (GO:0006586)2.48548240
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46949736
146smoothened signaling pathway (GO:0007224)2.46460545
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44967603
148negative regulation of reactive oxygen species metabolic process (GO:2000378)2.44089693
149adaptation of signaling pathway (GO:0023058)2.42849156
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.42818195
151cornea development in camera-type eye (GO:0061303)2.42627658
152respiratory chain complex IV assembly (GO:0008535)2.41365573
153fusion of sperm to egg plasma membrane (GO:0007342)14.0011581
154cilium or flagellum-dependent cell motility (GO:0001539)13.3501711
155cell wall macromolecule metabolic process (GO:0044036)12.9282280
156cell wall macromolecule catabolic process (GO:0016998)12.9282280
157sperm motility (GO:0030317)12.4530142
158acrosome assembly (GO:0001675)12.3543029
159axonemal dynein complex assembly (GO:0070286)11.6624201
160multicellular organism reproduction (GO:0032504)11.4528264
161sperm-egg recognition (GO:0035036)11.2759360
162epithelial cilium movement (GO:0003351)11.1836634
163plasma membrane fusion (GO:0045026)10.6784549
164binding of sperm to zona pellucida (GO:0007339)10.3025548
165acrosome reaction (GO:0007340)10.1761417
166cilium movement (GO:0003341)10.0954872
167cell-cell recognition (GO:0009988)10.0915607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.50708055
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.70653910
3EZH2_22144423_ChIP-Seq_EOC_Human4.32314827
4IGF1R_20145208_ChIP-Seq_DFB_Human3.95383306
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.69839660
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56789401
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88227152
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80975552
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.71155280
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70697932
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.68848055
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56842175
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56751358
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48097647
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36882869
16GBX2_23144817_ChIP-Seq_PC3_Human2.29883767
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29538040
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18865143
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.18630826
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.14285211
21ZNF274_21170338_ChIP-Seq_K562_Hela2.11914774
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09383379
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07341220
24EWS_26573619_Chip-Seq_HEK293_Human2.03392763
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse2.00117529
26FUS_26573619_Chip-Seq_HEK293_Human1.97148741
27MYC_18940864_ChIP-ChIP_HL60_Human1.94769771
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94644214
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.94506952
30VDR_22108803_ChIP-Seq_LS180_Human1.92168076
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87166373
32P300_19829295_ChIP-Seq_ESCs_Human1.86653648
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.83430602
34* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.79548954
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77449217
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77100914
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.75327420
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70355964
39IRF1_19129219_ChIP-ChIP_H3396_Human1.68257026
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66500573
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65599047
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64706509
43KDM2B_26808549_Chip-Seq_REH_Human1.64152155
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64071072
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.63492592
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.62773987
47BCAT_22108803_ChIP-Seq_LS180_Human1.61950473
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60484898
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59311041
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59025351
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.58294042
52ELK1_19687146_ChIP-ChIP_HELA_Human1.57673767
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57592774
54VDR_23849224_ChIP-Seq_CD4+_Human1.56391338
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55095472
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.54538566
57* STAT1_17558387_ChIP-Seq_HELA_Human1.53520932
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50670259
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49842518
60TP53_22573176_ChIP-Seq_HFKS_Human1.48303122
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48140129
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47359178
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.46659279
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45639437
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44151605
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43973005
67CBP_20019798_ChIP-Seq_JUKART_Human1.43973005
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.43952421
69FOXP3_21729870_ChIP-Seq_TREG_Human1.43273333
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.41028101
71RNF2_27304074_Chip-Seq_NSC_Mouse1.39230603
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.35181628
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34461625
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.34076868
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32406633
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32294147
77P53_22387025_ChIP-Seq_ESCs_Mouse1.31891919
78REST_21632747_ChIP-Seq_MESCs_Mouse1.31619683
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30748429
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30196347
81* GATA3_21867929_ChIP-Seq_CD8_Mouse1.30096084
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29924437
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.29903344
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29900528
85AR_25329375_ChIP-Seq_VCAP_Human1.27411956
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27355855
87* OCT4_18555785_Chip-Seq_ESCs_Mouse1.26275453
88TCF4_22108803_ChIP-Seq_LS180_Human1.25941907
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25793373
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25793373
91* SMAD4_21799915_ChIP-Seq_A2780_Human1.25143885
92GATA3_21867929_ChIP-Seq_TH1_Mouse1.24984369
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24632410
94NCOR_22424771_ChIP-Seq_293T_Human1.24581031
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24217637
96FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24138902
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23793609
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22943317
99* P300_18555785_Chip-Seq_ESCs_Mouse1.22634818
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22586693
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.22290726
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21505618
103E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20866607
104TAF15_26573619_Chip-Seq_HEK293_Human1.20815050
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.19714012
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.19564302
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18422875
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.18011338
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16701184
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16434758
111* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16002101
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15575051
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15490232
114GABP_19822575_ChIP-Seq_HepG2_Human1.15165463
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15010664
116RUNX2_22187159_ChIP-Seq_PCA_Human1.14964837
117* KLF4_18555785_Chip-Seq_ESCs_Mouse1.14441294
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12503214
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11300574
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.11201651
121STAT3_23295773_ChIP-Seq_U87_Human1.11017108
122* AR_20517297_ChIP-Seq_VCAP_Human1.09549623
123P53_21459846_ChIP-Seq_SAOS-2_Human1.09403701
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09210377
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08884317
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08696422
127GF1_26923725_Chip-Seq_HPCs_Mouse1.07394561
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.06037766
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05329040
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05299706
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.04168251
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04156720
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03638694
134PU1_27457419_Chip-Seq_LIVER_Mouse1.03339226
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.02637096
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02245411
137FOXH1_21741376_ChIP-Seq_EPCs_Human1.01840664
138ER_23166858_ChIP-Seq_MCF-7_Human1.01650335
139* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01028524
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00148331
141SOX9_26525672_Chip-Seq_HEART_Mouse0.99272289
142ZFX_18555785_Chip-Seq_ESCs_Mouse0.98993820
143NANOG_19829295_ChIP-Seq_ESCs_Human0.98978922
144SOX2_19829295_ChIP-Seq_ESCs_Human0.98978922
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98976424
146CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97844578
147NMYC_18555785_Chip-Seq_ESCs_Mouse0.97719025
148GF1B_26923725_Chip-Seq_HPCs_Mouse0.97012239
149SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96907026
150FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96516440
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96359479
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95722630
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94666964
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.94304777
155TBL1_22424771_ChIP-Seq_293T_Human0.92224851
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92145446
157* CBP_21632823_ChIP-Seq_H3396_Human0.92065660
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92033946
159ERG_20517297_ChIP-Seq_VCAP_Human0.91937689
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90758146
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.88430930
162SPI1_26923725_Chip-Seq_HPCs_Mouse0.87931818
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87784766
164FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87495432
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86079626
166TCF4_23295773_ChIP-Seq_U87_Human0.85518629
167FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85068176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.01167602
2* MP0001929_abnormal_gametogenesis5.50268112
3MP0008877_abnormal_DNA_methylation4.98518009
4MP0002210_abnormal_sex_determination3.74486841
5MP0002653_abnormal_ependyma_morphology3.58768352
6* MP0002161_abnormal_fertility/fecundity3.21626584
7MP0001145_abnormal_male_reproductive3.13503946
8MP0006292_abnormal_olfactory_placode3.13477812
9MP0003880_abnormal_central_pattern2.78436187
10MP0000653_abnormal_sex_gland2.73946391
11MP0003787_abnormal_imprinting2.66749960
12MP0008789_abnormal_olfactory_epithelium2.64178428
13MP0005623_abnormal_meninges_morphology2.59738191
14MP0005499_abnormal_olfactory_system2.22970853
15MP0005394_taste/olfaction_phenotype2.22970853
16MP0001346_abnormal_lacrimal_gland2.17055406
17MP0003195_calcinosis2.15027328
18MP0003121_genomic_imprinting2.00903869
19MP0005410_abnormal_fertilization15.3420199
20MP0001529_abnormal_vocalization1.92205317
21MP0002160_abnormal_reproductive_system1.87738752
22MP0005670_abnormal_white_adipose1.86814031
23MP0003890_abnormal_embryonic-extraembry1.86575467
24MP0006276_abnormal_autonomic_nervous1.86044229
25MP0002938_white_spotting1.78364182
26MP0001485_abnormal_pinna_reflex1.70838525
27MP0002163_abnormal_gland_morphology1.65156385
28MP0009046_muscle_twitch1.61010529
29MP0010030_abnormal_orbit_morphology1.60705462
30MP0002282_abnormal_trachea_morphology1.58202225
31MP0003122_maternal_imprinting1.57538380
32MP0000383_abnormal_hair_follicle1.55446198
33MP0008057_abnormal_DNA_replication1.55114753
34MP0001986_abnormal_taste_sensitivity1.52747732
35MP0001984_abnormal_olfaction1.50483374
36MP0008872_abnormal_physiological_respon1.38473673
37MP0000049_abnormal_middle_ear1.33187136
38MP0002233_abnormal_nose_morphology1.32740406
39MP0000631_abnormal_neuroendocrine_gland1.29980028
40MP0003718_maternal_effect1.29963797
41MP0003938_abnormal_ear_development1.27232447
42MP0008058_abnormal_DNA_repair1.23894806
43MP0001765_abnormal_ion_homeostasis1.21975580
44MP0005647_abnormal_sex_gland1.18267477
45MP0002751_abnormal_autonomic_nervous1.16864791
46MP0002638_abnormal_pupillary_reflex1.14380045
47MP0002876_abnormal_thyroid_physiology1.14296701
48MP0000026_abnormal_inner_ear1.11984344
49MP0004233_abnormal_muscle_weight1.09093785
50MP0003646_muscle_fatigue1.07744783
51MP0004142_abnormal_muscle_tone1.04800425
52MP0005083_abnormal_biliary_tract1.04477721
53MP0001963_abnormal_hearing_physiology1.00677934
54MP0000372_irregular_coat_pigmentation1.00422563
55MP0002735_abnormal_chemical_nociception0.99925071
56MP0001286_abnormal_eye_development0.99520051
57MP0005248_abnormal_Harderian_gland0.99500316
58MP0005389_reproductive_system_phenotype0.99003289
59MP0010678_abnormal_skin_adnexa0.97926019
60MP0005408_hypopigmentation0.96216399
61MP0003937_abnormal_limbs/digits/tail_de0.93349768
62MP0003806_abnormal_nucleotide_metabolis0.89853187
63MP0003011_delayed_dark_adaptation0.88167976
64MP0002184_abnormal_innervation0.87883152
65MP0002234_abnormal_pharynx_morphology0.87236283
66MP0003119_abnormal_digestive_system0.87055320
67MP0008995_early_reproductive_senescence0.86361816
68MP0001486_abnormal_startle_reflex0.85848859
69MP0000955_abnormal_spinal_cord0.85474926
70MP0000647_abnormal_sebaceous_gland0.81707835
71MP0005084_abnormal_gallbladder_morpholo0.81698730
72MP0002067_abnormal_sensory_capabilities0.80952176
73MP0003943_abnormal_hepatobiliary_system0.78171751
74MP0003186_abnormal_redox_activity0.77997684
75MP0001348_abnormal_lacrimal_gland0.77520150
76MP0002734_abnormal_mechanical_nocicepti0.77336201
77MP0001970_abnormal_pain_threshold0.76259180
78MP0003635_abnormal_synaptic_transmissio0.75768127
79MP0001905_abnormal_dopamine_level0.75395711
80MP0002095_abnormal_skin_pigmentation0.74965554
81MP0005551_abnormal_eye_electrophysiolog0.71414099
82MP0002928_abnormal_bile_duct0.70565184
83MP0002102_abnormal_ear_morphology0.64815864
84MP0005636_abnormal_mineral_homeostasis0.64304835
85MP0010094_abnormal_chromosome_stability0.62944832
86MP0003950_abnormal_plasma_membrane0.62898536
87MP0005253_abnormal_eye_physiology0.60604570
88MP0004134_abnormal_chest_morphology0.57660617
89MP0003786_premature_aging0.56646024
90MP0003136_yellow_coat_color0.56161079
91MP0004133_heterotaxia0.55589169
92MP0004036_abnormal_muscle_relaxation0.49571688
93MP0001324_abnormal_eye_pigmentation0.48562862
94MP0006072_abnormal_retinal_apoptosis0.48084133
95MP0004019_abnormal_vitamin_homeostasis0.47992137
96MP0005646_abnormal_pituitary_gland0.47517438
97MP0000358_abnormal_cell_content/0.47123560
98MP0002736_abnormal_nociception_after0.46563610
99MP0001293_anophthalmia0.44431915
100MP0005377_hearing/vestibular/ear_phenot0.43851875
101MP0003878_abnormal_ear_physiology0.43851875
102MP0005391_vision/eye_phenotype0.43187347
103MP0003699_abnormal_female_reproductive0.42941537
104MP0003329_amyloid_beta_deposits0.41560178
105MP0003633_abnormal_nervous_system0.41048420
106MP0002971_abnormal_brown_adipose0.40504188
107MP0008007_abnormal_cellular_replicative0.40195330
108MP0001119_abnormal_female_reproductive0.38381655
109MP0000569_abnormal_digit_pigmentation0.35660328
110MP0002152_abnormal_brain_morphology0.35301687
111MP0001968_abnormal_touch/_nociception0.34917174
112MP0001764_abnormal_homeostasis0.33887490
113MP0003115_abnormal_respiratory_system0.33537464
114MP0006036_abnormal_mitochondrial_physio0.32485934
115MP0003634_abnormal_glial_cell0.32261353
116MP0003861_abnormal_nervous_system0.32064752
117MP0001440_abnormal_grooming_behavior0.31283027
118MP0001727_abnormal_embryo_implantation0.30037168
119MP0002132_abnormal_respiratory_system0.28887727
120MP0004145_abnormal_muscle_electrophysio0.27694760
121MP0009115_abnormal_fat_cell0.27515163
122MP0005666_abnormal_adipose_tissue0.27426732
123MP0002229_neurodegeneration0.27349454
124MP0002572_abnormal_emotion/affect_behav0.27190220
125MP0003631_nervous_system_phenotype0.27011739
126MP0005195_abnormal_posterior_eye0.26812752
127MP0004811_abnormal_neuron_physiology0.26228191
128MP0005388_respiratory_system_phenotype0.25489604
129MP0002133_abnormal_respiratory_system0.25489604
130MP0000778_abnormal_nervous_system0.25315681
131MP0004270_analgesia0.24880064
132MP0009250_abnormal_appendicular_skeleto0.24289523
133MP0008875_abnormal_xenobiotic_pharmacok0.24006950
134MP0004742_abnormal_vestibular_system0.23595372
135MP0002269_muscular_atrophy0.23207833
136MP0005397_hematopoietic_system_phenotyp0.22509670
137MP0001545_abnormal_hematopoietic_system0.22509670
138MP0006035_abnormal_mitochondrial_morpho0.21558479
139MP0000427_abnormal_hair_cycle0.20427492
140MP0010307_abnormal_tumor_latency0.19908403
141MP0002092_abnormal_eye_morphology0.19710171
142MP0002752_abnormal_somatic_nervous0.19648359
143MP0002557_abnormal_social/conspecific_i0.19094082
144MP0002272_abnormal_nervous_system0.19037184
145MP0002837_dystrophic_cardiac_calcinosis0.18969331
146MP0004043_abnormal_pH_regulation0.18712897
147MP0000432_abnormal_head_morphology0.18397693
148MP0004808_abnormal_hematopoietic_stem0.17710941
149MP0003879_abnormal_hair_cell0.17690917
150MP0002882_abnormal_neuron_morphology0.17344795
151MP0009745_abnormal_behavioral_response0.16870668
152MP0005423_abnormal_somatic_nervous0.16255520
153MP0000604_amyloidosis0.15858585
154MP0008569_lethality_at_weaning0.15665923
155MP0001851_eye_inflammation0.15617093

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.61476153
2Abnormal respiratory epithelium morphology (HP:0012253)9.61476153
3Abnormal ciliary motility (HP:0012262)9.28450044
4Rhinitis (HP:0012384)8.65106125
5Chronic bronchitis (HP:0004469)7.58302878
6Nasal polyposis (HP:0100582)6.19785254
7Infertility (HP:0000789)5.75748825
8Abnormality of the nasal mucosa (HP:0000433)5.07667547
9Bronchiectasis (HP:0002110)4.94169068
10Bronchitis (HP:0012387)4.41145970
11Nephronophthisis (HP:0000090)4.22531201
12Recurrent sinusitis (HP:0011108)3.93035261
13Abnormality of the renal medulla (HP:0100957)3.24995458
14Recurrent otitis media (HP:0000403)3.22920477
15Male infertility (HP:0003251)3.19004833
16Medial flaring of the eyebrow (HP:0010747)3.07093439
17Sclerocornea (HP:0000647)2.99808442
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96549276
19Tubulointerstitial nephritis (HP:0001970)2.96131866
20Molar tooth sign on MRI (HP:0002419)2.87775880
21Abnormality of midbrain morphology (HP:0002418)2.87775880
22Aplasia/Hypoplasia of the spleen (HP:0010451)2.55380313
23Abnormal spermatogenesis (HP:0008669)2.54746209
24Abnormal rod and cone electroretinograms (HP:0008323)2.47236120
25Acute necrotizing encephalopathy (HP:0006965)2.44878771
26Hyperventilation (HP:0002883)2.42273990
27Tubular atrophy (HP:0000092)2.41903799
28Asplenia (HP:0001746)2.34809069
293-Methylglutaconic aciduria (HP:0003535)2.34622890
30Fibular hypoplasia (HP:0003038)2.33109451
31Chronic sinusitis (HP:0011109)2.32651378
32Increased CSF lactate (HP:0002490)2.31966696
33Tubulointerstitial abnormality (HP:0001969)2.31595723
34Recurrent bronchitis (HP:0002837)2.29708031
35Preaxial hand polydactyly (HP:0001177)2.29466746
36Abnormality of the lower motor neuron (HP:0002366)2.23052350
37Hypoplastic pelvis (HP:0008839)2.19330578
38Hip dysplasia (HP:0001385)2.17662471
39Gonadotropin excess (HP:0000837)2.15688847
40Colon cancer (HP:0003003)2.13537919
41Postaxial foot polydactyly (HP:0001830)2.12212703
42Gait imbalance (HP:0002141)2.11023422
43Congenital primary aphakia (HP:0007707)2.10850562
44Pancreatic fibrosis (HP:0100732)2.10299948
45Mitochondrial inheritance (HP:0001427)2.10206210
46Narrow forehead (HP:0000341)2.10178253
47Abnormal mitochondria in muscle tissue (HP:0008316)2.09033030
48Male pseudohermaphroditism (HP:0000037)2.05301054
49Acute encephalopathy (HP:0006846)2.03666527
50Congenital hepatic fibrosis (HP:0002612)2.01119636
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8754786
52Dynein arm defect of respiratory motile cilia (HP:0012255)12.6983648
53Absent/shortened dynein arms (HP:0200106)12.6983648
54Abnormal respiratory motile cilium physiology (HP:0012261)10.5552092
55Progressive macrocephaly (HP:0004481)1.99425202
56Small hand (HP:0200055)1.97072778
57Specific learning disability (HP:0001328)1.96657741
58Stage 5 chronic kidney disease (HP:0003774)1.96551720
59Polyphagia (HP:0002591)1.96092088
60Abnormality of the dental root (HP:0006486)1.93079700
61Taurodontia (HP:0000679)1.93079700
62Abnormality of permanent molar morphology (HP:0011071)1.93079700
63Atrophy/Degeneration involving motor neurons (HP:0007373)1.89457798
64Hepatocellular necrosis (HP:0001404)1.89432717
65Azoospermia (HP:0000027)1.89020714
66Astigmatism (HP:0000483)1.88909247
67Widely spaced teeth (HP:0000687)1.85434997
68Abnormality of dentin (HP:0010299)1.85019751
69Bony spicule pigmentary retinopathy (HP:0007737)1.84601742
70Multicystic kidney dysplasia (HP:0000003)1.84555551
71True hermaphroditism (HP:0010459)1.83099250
72Aganglionic megacolon (HP:0002251)1.82796577
73Nephrogenic diabetes insipidus (HP:0009806)1.81443167
74Abnormality of molar (HP:0011077)1.80180134
75Abnormality of molar morphology (HP:0011070)1.80180134
76Broad foot (HP:0001769)1.79953523
77Amyotrophic lateral sclerosis (HP:0007354)1.79907380
78Retinitis pigmentosa (HP:0000510)1.79442736
79Bifid tongue (HP:0010297)1.79276452
80Septo-optic dysplasia (HP:0100842)1.79164720
81Absent speech (HP:0001344)1.79139848
82Retinal dysplasia (HP:0007973)1.79079768
83Disproportionate short-trunk short stature (HP:0003521)1.78885803
84Abnormality of the dental pulp (HP:0006479)1.76967339
85Type I transferrin isoform profile (HP:0003642)1.76946412
86Cystic liver disease (HP:0006706)1.75697808
87Oculomotor apraxia (HP:0000657)1.74544773
88Abnormality of the renal cortex (HP:0011035)1.74116471
89Postaxial hand polydactyly (HP:0001162)1.71606320
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.70970158
91Tubulointerstitial fibrosis (HP:0005576)1.70598154
92Median cleft lip (HP:0000161)1.70208729
93Cerebral edema (HP:0002181)1.69615078
94Polyuria (HP:0000103)1.69403434
95Supernumerary spleens (HP:0009799)1.67770966
96Abnormal drinking behavior (HP:0030082)1.66203605
97Polydipsia (HP:0001959)1.66203605
98Increased serum lactate (HP:0002151)1.65292267
99Decreased testicular size (HP:0008734)1.64684002
100Facial cleft (HP:0002006)1.63670090
101Lipid accumulation in hepatocytes (HP:0006561)1.63344825
102Attenuation of retinal blood vessels (HP:0007843)1.62584448
103Prominent nasal bridge (HP:0000426)1.61840717
104Furrowed tongue (HP:0000221)1.61279368
105Genital tract atresia (HP:0001827)1.59453047
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59428779
107Abnormal protein N-linked glycosylation (HP:0012347)1.59428779
108Abnormal protein glycosylation (HP:0012346)1.59428779
109Abnormal glycosylation (HP:0012345)1.59428779
110Hepatic necrosis (HP:0002605)1.59272082
111Genetic anticipation (HP:0003743)1.58564466
112Broad-based gait (HP:0002136)1.57459302
113Poor coordination (HP:0002370)1.56377569
114Vaginal atresia (HP:0000148)1.55451968
115Aplasia/Hypoplasia of the lens (HP:0008063)1.54918935
116Microglossia (HP:0000171)1.54563031
117Abnormality of renal excretion (HP:0011036)1.52337101
118Abnormal biliary tract physiology (HP:0012439)1.50870815
119Bile duct proliferation (HP:0001408)1.50870815
120Short ribs (HP:0000773)1.50454686
121Pancreatic cysts (HP:0001737)1.48904941
122Renal dysplasia (HP:0000110)1.48395815
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.47122328
124Impulsivity (HP:0100710)1.44442029
12511 pairs of ribs (HP:0000878)1.37878121
126Impaired proprioception (HP:0010831)1.37005396
127Decreased central vision (HP:0007663)1.35918366
128Chronic hepatic failure (HP:0100626)1.35743875
129Absent frontal sinuses (HP:0002688)1.34325004
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.32211591
131J-shaped sella turcica (HP:0002680)1.32062202
132Bell-shaped thorax (HP:0001591)1.32053899
133Dyschromatopsia (HP:0007641)1.30271389
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.29053686
135Occipital encephalocele (HP:0002085)1.27522681
136Nephropathy (HP:0000112)1.23265764
137Abnormality of ocular smooth pursuit (HP:0000617)1.23043784
138Cholecystitis (HP:0001082)1.21025284
139Abnormal gallbladder physiology (HP:0012438)1.21025284
140Abnormality of saccadic eye movements (HP:0000570)1.20799155
141Short thorax (HP:0010306)1.19079015
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16747593
143Upper motor neuron abnormality (HP:0002127)1.16554835
144Abnormal urine output (HP:0012590)1.14489124
145Breast carcinoma (HP:0003002)1.13794201
146Short nail (HP:0001799)1.12265719
147Asymmetric septal hypertrophy (HP:0001670)1.11833766
148Abnormality of renal resorption (HP:0011038)1.09861264
149Optic nerve hypoplasia (HP:0000609)1.08987729
150Vascular calcification (HP:0004934)1.07411156
151Broad distal phalanx of finger (HP:0009836)1.06643090
152Anencephaly (HP:0002323)1.06331165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.81690128
2PDK49.81690128
3PDK26.39119136
4BCR4.48936051
5MAP4K23.78518545
6FRK3.59243362
7TESK13.28705875
8STK163.19430241
9CDK192.81805396
10PRKD32.59419776
11CASK2.52515418
12MST42.41545851
13PNCK2.39544578
14ICK2.39260013
15NUAK12.16560583
16STK392.12499182
17WNK42.10682668
18PTK2B2.10425710
19SRPK11.91207922
20BCKDK1.83812028
21TRIM281.83347452
22TNIK1.69031593
23MAPK151.63279883
24INSRR1.54070008
25MKNK21.42539609
26MAPK131.41805831
27EPHA41.40750324
28ZAK1.32778548
29ADRBK21.29674068
30NEK21.24413437
31DYRK21.24292881
32TNK21.17720392
33PLK21.10719811
34FER1.10654440
35TSSK61.09597380
36EIF2AK31.07115540
37TXK1.04398567
38STK381.03044027
39NME11.00610775
40CSNK1G10.99133466
41ACVR1B0.97953043
42ADRBK10.97835464
43PDK10.96325598
44CSNK1G30.95962680
45IRAK10.95623823
46TGFBR20.94910453
47PAK30.86574050
48TLK10.86363274
49CSNK1A1L0.86121301
50WNK10.84053316
51LMTK20.83724993
52VRK10.82732229
53TYRO30.80375958
54VRK20.79831838
55DYRK1B0.78903325
56RPS6KB20.77413074
57PBK0.76960898
58CSNK1G20.74595660
59PASK0.72127025
60MKNK10.66168566
61DYRK30.65748466
62CCNB10.65063703
63WEE10.64251693
64FGFR10.63497415
65STK30.61744603
66MAP3K120.60776594
67TGFBR10.58176935
68PRKCE0.56808655
69CAMKK20.56141304
70TTK0.48220638
71PINK10.47928231
72CHEK20.46484592
73PLK30.46401555
74MATK0.45530636
75NTRK20.44997414
76PLK40.42541920
77CDC70.42439710
78PRKCI0.41486768
79MAPKAPK30.40629662
80CSNK1A10.40593520
81STK38L0.39965132
82FLT30.39827746
83MAP2K60.39489400
84MET0.38649583
85MAP3K50.38257264
86MUSK0.36453229
87CHEK10.36228601
88CAMK1G0.35221224
89IRAK20.35170550
90PDPK10.35018650
91FGR0.34890040
92DYRK1A0.33462543
93MAP2K70.32997969
94AURKB0.32954202
95ERBB30.32821294
96PRKCG0.32778555
97MAP3K90.32325060
98CSNK1E0.31029503
99BRSK20.30569274
100ERBB40.30204673
101TAOK30.29390661
102NLK0.28278060
103ATR0.26791396
104ATM0.24987236
105MAP3K40.24375719
106PAK20.23786158
107RIPK40.23723405
108NEK60.20847678
109PAK10.19780667
110CAMKK10.19618911
111WNK30.16852687
112MAPKAPK50.16268087
113TESK20.15512449
114PLK10.15210069
115EEF2K0.14676229
116BRAF0.14197069
117PRKG10.13652401
118CDK30.13544041
119RPS6KB10.12663182
120PRKAA10.12321576
121BMPR1B0.11863958
122PKN10.11590834
123PRKACG0.10679167
124PRKCQ0.10468295
125MTOR0.10184418
126MARK30.09082622
127PRKCZ0.08910077
128CAMK2A0.07700930
129CSNK2A10.06429850
130PRKG20.06191321
131GRK10.05454061
132CDK150.05356977
133MARK20.04880716
134GSK3A0.04866550
135AURKA0.04680616
136MAPK100.04408180
137CSNK2A20.03997027
138BRSK10.03733988
139CDK180.03622562
140CSNK1D0.03594977
141PRKACA0.03364997
142CDK120.03352640
143YES10.03080913
144GSK3B0.03074845
145PRKACB0.02563665
146MAPK80.02498116
147CDK140.02151993
148PRKDC0.02151559
149MAP3K100.02105661
150CDK11A0.02023525
151MARK10.01885551
152MINK10.01757562
153CDK10.01450503
154STK100.01315817
155PRKCB0.01166988
156EGFR0.00987713
157OXSR10.00608929
158PRKCA0.00539400
159RPS6KA1-0.0140657
160CDK2-0.0123256
161STK11-0.0073029
162RPS6KA3-0.0034404

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.30876479
2Pyruvate metabolism_Homo sapiens_hsa006204.38325245
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.15646336
4Propanoate metabolism_Homo sapiens_hsa006403.39705233
5Non-homologous end-joining_Homo sapiens_hsa034502.97038324
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94241433
7Fatty acid biosynthesis_Homo sapiens_hsa000612.91624140
8Glucagon signaling pathway_Homo sapiens_hsa049222.80950206
9Basal transcription factors_Homo sapiens_hsa030222.63345286
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.41971397
11Pentose phosphate pathway_Homo sapiens_hsa000302.41337841
12Proteasome_Homo sapiens_hsa030502.35459708
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33470110
14Linoleic acid metabolism_Homo sapiens_hsa005912.31023093
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28338842
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.18923860
17Homologous recombination_Homo sapiens_hsa034402.15638800
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14093044
19Huntingtons disease_Homo sapiens_hsa050162.11003452
20Parkinsons disease_Homo sapiens_hsa050122.06973319
21Selenocompound metabolism_Homo sapiens_hsa004502.04188142
22Protein export_Homo sapiens_hsa030601.96957746
23Oocyte meiosis_Homo sapiens_hsa041141.94941550
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88811022
25RNA polymerase_Homo sapiens_hsa030201.88007255
26Dorso-ventral axis formation_Homo sapiens_hsa043201.82568652
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80435810
28Glycerolipid metabolism_Homo sapiens_hsa005611.79027638
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78589422
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75619807
31Fanconi anemia pathway_Homo sapiens_hsa034601.74101703
32RNA degradation_Homo sapiens_hsa030181.71193629
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66585987
34Amphetamine addiction_Homo sapiens_hsa050311.65806767
35Steroid biosynthesis_Homo sapiens_hsa001001.65020413
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63515316
37Butanoate metabolism_Homo sapiens_hsa006501.60882526
38Mismatch repair_Homo sapiens_hsa034301.60057967
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58013425
40Regulation of autophagy_Homo sapiens_hsa041401.57450726
41PPAR signaling pathway_Homo sapiens_hsa033201.56722200
42Cardiac muscle contraction_Homo sapiens_hsa042601.48876952
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.48049161
44Ribosome_Homo sapiens_hsa030101.45166610
45Renin secretion_Homo sapiens_hsa049241.43776090
46Caffeine metabolism_Homo sapiens_hsa002321.42413423
47Peroxisome_Homo sapiens_hsa041461.41914120
48Tryptophan metabolism_Homo sapiens_hsa003801.40520700
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39788575
50Carbon metabolism_Homo sapiens_hsa012001.37106802
51Nucleotide excision repair_Homo sapiens_hsa034201.32950243
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.29766604
53Fatty acid elongation_Homo sapiens_hsa000621.26388154
54Ether lipid metabolism_Homo sapiens_hsa005651.24705125
55Glycerophospholipid metabolism_Homo sapiens_hsa005641.23302798
56Mineral absorption_Homo sapiens_hsa049781.19415180
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13803375
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11895437
59Purine metabolism_Homo sapiens_hsa002301.10114529
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08600509
61Base excision repair_Homo sapiens_hsa034101.08293536
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07549912
63Nitrogen metabolism_Homo sapiens_hsa009101.07338923
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05598205
65beta-Alanine metabolism_Homo sapiens_hsa004101.05463349
66Collecting duct acid secretion_Homo sapiens_hsa049661.04106459
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02517378
68Fructose and mannose metabolism_Homo sapiens_hsa000511.02229560
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00971209
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00892056
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00183063
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.99969661
73Nicotine addiction_Homo sapiens_hsa050330.99582344
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98119624
75DNA replication_Homo sapiens_hsa030300.97869259
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97282917
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95421537
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94821348
79Fat digestion and absorption_Homo sapiens_hsa049750.93308098
80Antigen processing and presentation_Homo sapiens_hsa046120.92405125
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90794982
82Long-term potentiation_Homo sapiens_hsa047200.88770624
83Histidine metabolism_Homo sapiens_hsa003400.88693665
84Biosynthesis of amino acids_Homo sapiens_hsa012300.88256819
85Spliceosome_Homo sapiens_hsa030400.88011118
86Phenylalanine metabolism_Homo sapiens_hsa003600.86320359
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84894125
88Glutathione metabolism_Homo sapiens_hsa004800.84625554
89mRNA surveillance pathway_Homo sapiens_hsa030150.83288185
90Sulfur metabolism_Homo sapiens_hsa009200.83094902
91Calcium signaling pathway_Homo sapiens_hsa040200.81555853
92Insulin secretion_Homo sapiens_hsa049110.80777221
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75954618
94Fatty acid metabolism_Homo sapiens_hsa012120.75537557
95One carbon pool by folate_Homo sapiens_hsa006700.75385196
96Chemical carcinogenesis_Homo sapiens_hsa052040.74662775
97Estrogen signaling pathway_Homo sapiens_hsa049150.71700941
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71045661
99Fatty acid degradation_Homo sapiens_hsa000710.70878540
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70739479
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66873826
102Morphine addiction_Homo sapiens_hsa050320.66657033
103Lysine degradation_Homo sapiens_hsa003100.66614179
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66031967
105GABAergic synapse_Homo sapiens_hsa047270.65501702
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64662248
107p53 signaling pathway_Homo sapiens_hsa041150.63933019
108Arginine and proline metabolism_Homo sapiens_hsa003300.62714372
109Renin-angiotensin system_Homo sapiens_hsa046140.61998438
110Taste transduction_Homo sapiens_hsa047420.61664817
111ABC transporters_Homo sapiens_hsa020100.61263168
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.61223061
113Arachidonic acid metabolism_Homo sapiens_hsa005900.60954194
114Thyroid hormone synthesis_Homo sapiens_hsa049180.60702366
115RNA transport_Homo sapiens_hsa030130.60502322
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60286248
117Basal cell carcinoma_Homo sapiens_hsa052170.59751312
118Inositol phosphate metabolism_Homo sapiens_hsa005620.58281750
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57915658
120Tyrosine metabolism_Homo sapiens_hsa003500.57728986
121Olfactory transduction_Homo sapiens_hsa047400.56862824
122Synaptic vesicle cycle_Homo sapiens_hsa047210.55200845
123Sulfur relay system_Homo sapiens_hsa041220.53801691
124Bile secretion_Homo sapiens_hsa049760.53551585
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51504943
126Circadian entrainment_Homo sapiens_hsa047130.50188774
127Serotonergic synapse_Homo sapiens_hsa047260.49074647
128Metabolic pathways_Homo sapiens_hsa011000.49063058
129Gastric acid secretion_Homo sapiens_hsa049710.48236951
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.47827500
131Salivary secretion_Homo sapiens_hsa049700.45705844
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.44901420
133Pancreatic secretion_Homo sapiens_hsa049720.44172098
134Systemic lupus erythematosus_Homo sapiens_hsa053220.43001942
135Hedgehog signaling pathway_Homo sapiens_hsa043400.41951056
136Hippo signaling pathway_Homo sapiens_hsa043900.38072513
137Alzheimers disease_Homo sapiens_hsa050100.36819991
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.36242683
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.35386533
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34832337
141cAMP signaling pathway_Homo sapiens_hsa040240.34626926
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33619951
143Oxidative phosphorylation_Homo sapiens_hsa001900.33305507
144N-Glycan biosynthesis_Homo sapiens_hsa005100.33194928
145Glutamatergic synapse_Homo sapiens_hsa047240.32845246
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32543060
147AMPK signaling pathway_Homo sapiens_hsa041520.30845214
148Protein digestion and absorption_Homo sapiens_hsa049740.29402974
149Endocytosis_Homo sapiens_hsa041440.24844167
150VEGF signaling pathway_Homo sapiens_hsa043700.24836704
151Wnt signaling pathway_Homo sapiens_hsa043100.24820838
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23692239
153Phototransduction_Homo sapiens_hsa047440.23239532
154Dopaminergic synapse_Homo sapiens_hsa047280.22470991
155Pyrimidine metabolism_Homo sapiens_hsa002400.21727596
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20942424
157Legionellosis_Homo sapiens_hsa051340.20494043
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20304013
159Cocaine addiction_Homo sapiens_hsa050300.19755897
160Alcoholism_Homo sapiens_hsa050340.18410806
161Retinol metabolism_Homo sapiens_hsa008300.18055127

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