MEIKIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)7.97463241
2DNA synthesis involved in DNA repair (GO:0000731)7.92061466
3cilium or flagellum-dependent cell motility (GO:0001539)7.37469287
4synaptonemal complex assembly (GO:0007130)7.31327073
5multicellular organism reproduction (GO:0032504)7.28803278
6synaptonemal complex organization (GO:0070193)7.20063980
7DNA methylation involved in gamete generation (GO:0043046)7.08283479
8fusion of sperm to egg plasma membrane (GO:0007342)6.63509646
9sperm motility (GO:0030317)6.49477660
10sperm-egg recognition (GO:0035036)6.40913951
11male meiosis I (GO:0007141)6.37333144
12binding of sperm to zona pellucida (GO:0007339)6.26532723
13histone H3-K9 demethylation (GO:0033169)6.20658426
14axonemal dynein complex assembly (GO:0070286)6.16468143
15acrosome assembly (GO:0001675)5.93987386
16reproduction (GO:0000003)5.75223114
17spermatid development (GO:0007286)5.72490780
18meiosis I (GO:0007127)5.71610747
19regulation of retinoic acid receptor signaling pathway (GO:0048385)5.71179778
20meiotic cell cycle (GO:0051321)5.69009973
21cell-cell recognition (GO:0009988)5.68901842
22positive regulation of meiosis (GO:0045836)5.68568254
23mitotic metaphase plate congression (GO:0007080)5.53898983
24protein localization to chromosome, centromeric region (GO:0071459)5.43468400
25positive regulation of meiotic cell cycle (GO:0051446)5.37255243
26meiotic nuclear division (GO:0007126)5.32330689
27microtubule depolymerization (GO:0007019)5.12056112
28epithelial cilium movement (GO:0003351)5.08391682
29chromosome organization involved in meiosis (GO:0070192)5.06006167
30protein localization to kinetochore (GO:0034501)5.00110226
31monoubiquitinated protein deubiquitination (GO:0035520)4.94824756
32plasma membrane fusion (GO:0045026)4.89242153
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.85817065
34regulation of meiotic cell cycle (GO:0051445)4.81089218
35single fertilization (GO:0007338)4.78513525
36motile cilium assembly (GO:0044458)4.76750385
37acrosome reaction (GO:0007340)4.68735250
38fertilization (GO:0009566)4.65294480
39regulation of cilium movement (GO:0003352)4.60359975
40regulation of meiosis I (GO:0060631)4.57416173
41metaphase plate congression (GO:0051310)4.55189594
42attachment of spindle microtubules to kinetochore (GO:0008608)4.48653205
43regulation of histone H3-K9 methylation (GO:0051570)4.44591191
44reciprocal meiotic recombination (GO:0007131)4.44391706
45reciprocal DNA recombination (GO:0035825)4.44391706
46meiotic cell cycle process (GO:1903046)4.37338452
47cilium movement (GO:0003341)4.33282225
48spermatogenesis (GO:0007283)4.21234449
49male gamete generation (GO:0048232)4.21045191
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.18476624
51regulation of spindle organization (GO:0090224)4.17691188
52gene silencing by RNA (GO:0031047)4.15904367
53regulation of acrosome reaction (GO:0060046)4.13726426
54gamete generation (GO:0007276)4.13248824
55histone exchange (GO:0043486)4.06449483
56establishment of chromosome localization (GO:0051303)4.04249792
57microtubule severing (GO:0051013)4.01907944
58negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)4.01506332
59negative regulation of inclusion body assembly (GO:0090084)3.97251857
60cell wall macromolecule catabolic process (GO:0016998)3.88668180
61cell wall macromolecule metabolic process (GO:0044036)3.88668180
62seminiferous tubule development (GO:0072520)3.86188269
63oocyte maturation (GO:0001556)3.84358686
64female gamete generation (GO:0007292)3.83833311
65protein localization to chromosome (GO:0034502)3.82531156
66positive regulation of chromosome segregation (GO:0051984)3.81973375
67germ cell development (GO:0007281)3.80087286
68protein K6-linked ubiquitination (GO:0085020)3.74109000
69cellular process involved in reproduction in multicellular organism (GO:0022412)3.70613501
70regulation of chromosome segregation (GO:0051983)3.66815684
71DNA alkylation (GO:0006305)3.60248509
72DNA methylation (GO:0006306)3.60248509
73DNA replication checkpoint (GO:0000076)3.59538510
74mitotic sister chromatid segregation (GO:0000070)3.59255605
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50009220
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50009220
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.50009220
78negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.46053110
79regulation of spindle checkpoint (GO:0090231)3.45050657
80negative regulation of meiosis (GO:0045835)3.44794266
81oogenesis (GO:0048477)3.44326641
82mitotic chromosome condensation (GO:0007076)3.43429776
83regulation of female gonad development (GO:2000194)3.38163069
84nuclear pore complex assembly (GO:0051292)3.37701960
85oocyte development (GO:0048599)3.37657456
86chromosome condensation (GO:0030261)3.35531182
87regulation of exit from mitosis (GO:0007096)3.32087552
88regulation of DNA methylation (GO:0044030)3.31312190
89sister chromatid cohesion (GO:0007062)3.31295531
90meiotic chromosome segregation (GO:0045132)3.31141757
91spindle checkpoint (GO:0031577)3.30754939
92negative regulation of reproductive process (GO:2000242)3.30623324
93gene silencing (GO:0016458)3.28581886
94regulation of centriole replication (GO:0046599)3.28320734
95regulation of meiosis (GO:0040020)3.26840938
96maturation of 5.8S rRNA (GO:0000460)3.24192485
97histone H3-K36 demethylation (GO:0070544)3.23639556
98chromatin remodeling at centromere (GO:0031055)3.22795474
99sperm capacitation (GO:0048240)3.22769342
100centriole replication (GO:0007099)3.22487796
101vitamin transmembrane transport (GO:0035461)3.21536631
102multicellular organismal reproductive process (GO:0048609)3.19662243
103regulation of mitotic spindle organization (GO:0060236)3.18249813
104regulation of inclusion body assembly (GO:0090083)3.17189520
105DNA packaging (GO:0006323)3.17164297
106CENP-A containing nucleosome assembly (GO:0034080)3.13554486
107negative regulation of DNA-templated transcription, elongation (GO:0032785)3.09462703
108negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09462703
109mitotic sister chromatid cohesion (GO:0007064)3.09243117
110microtubule polymerization or depolymerization (GO:0031109)3.08455002
111ribosome assembly (GO:0042255)3.08452041
112DNA methylation or demethylation (GO:0044728)3.07015182
113chromosome segregation (GO:0007059)3.05831704
114resolution of meiotic recombination intermediates (GO:0000712)2.99743997
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98317239
116DNA replication-independent nucleosome organization (GO:0034724)2.97492820
117DNA replication-independent nucleosome assembly (GO:0006336)2.97492820
118protein targeting to Golgi (GO:0000042)2.75740643
119negative regulation of meiotic cell cycle (GO:0051447)2.74014322
120histone lysine demethylation (GO:0070076)2.72770261
121mitotic spindle assembly checkpoint (GO:0007094)2.72330755
122cytoplasmic microtubule organization (GO:0031122)2.69927013
123genitalia morphogenesis (GO:0035112)2.69713606
124positive regulation of microtubule polymerization (GO:0031116)2.68984408
125chromosome organization (GO:0051276)2.68466041
126establishment of protein localization to Golgi (GO:0072600)2.67035555
127histone demethylation (GO:0016577)2.64979888
128spindle assembly checkpoint (GO:0071173)2.63285539
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62983027
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62983027
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62983027
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.62983027
133negative regulation of sister chromatid segregation (GO:0033046)2.62983027
134regulation of microtubule-based movement (GO:0060632)2.57717898
135proteasome assembly (GO:0043248)2.57705265
136reproductive system development (GO:0061458)2.56204196
137mitotic spindle checkpoint (GO:0071174)2.55710413
138negative regulation of chromosome segregation (GO:0051985)2.54707364
139interkinetic nuclear migration (GO:0022027)2.54446484
140regulation of female receptivity (GO:0045924)2.51874441
141regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.47978465
142retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47948158
143regulation of sister chromatid segregation (GO:0033045)2.46459185
144regulation of mitotic sister chromatid separation (GO:0010965)2.46459185
145regulation of mitotic sister chromatid segregation (GO:0033047)2.46459185
146centriole assembly (GO:0098534)2.46299603
147female mating behavior (GO:0060180)2.45992448
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.44295025
149potassium ion export (GO:0071435)2.44010177
150positive regulation of mast cell activation (GO:0033005)2.41572269
151protein demethylation (GO:0006482)2.41464685
152protein dealkylation (GO:0008214)2.41464685
153regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.40721442
154synapsis (GO:0007129)13.2716241
155piRNA metabolic process (GO:0034587)10.3660779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.00573561
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.79003624
3E2F7_22180533_ChIP-Seq_HELA_Human3.46783437
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26228966
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19050438
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16837067
7KAP1_22055183_ChIP-Seq_ESCs_Mouse3.08339584
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01087021
9AR_21909140_ChIP-Seq_LNCAP_Human2.99477392
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.98733772
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.98733772
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.98733772
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.95287086
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.72036532
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63777949
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52996815
17IGF1R_20145208_ChIP-Seq_DFB_Human2.45448258
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41063418
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29191476
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28099973
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.28035047
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.25673921
23ZNF274_21170338_ChIP-Seq_K562_Hela2.24486436
24EZH2_22144423_ChIP-Seq_EOC_Human2.23775524
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.02029679
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.94573108
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86893102
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.80885998
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74263620
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70720504
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.69096644
32RNF2_27304074_Chip-Seq_NSC_Mouse1.66874755
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66131309
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65272897
35PRDM14_20953172_ChIP-Seq_ESCs_Human1.60919229
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59599622
37BCAT_22108803_ChIP-Seq_LS180_Human1.59524987
38ER_23166858_ChIP-Seq_MCF-7_Human1.58889190
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57618351
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56141890
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56141890
42AR_25329375_ChIP-Seq_VCAP_Human1.54348256
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53713227
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53606973
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53479644
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53240110
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53055965
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52543436
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48764789
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.48611313
51VDR_24787735_ChIP-Seq_THP-1_Human1.45640353
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43937310
53RUNX1_26923725_Chip-Seq_HPCs_Mouse1.42546834
54RUNX2_22187159_ChIP-Seq_PCA_Human1.39019545
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.38016843
56STAT1_17558387_ChIP-Seq_HELA_Human1.37325556
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.35995894
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35954225
59STAT3_23295773_ChIP-Seq_U87_Human1.35560974
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.33088705
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32956277
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.32555641
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.30327524
64TP53_22573176_ChIP-Seq_HFKS_Human1.28123464
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.27427920
66VDR_23849224_ChIP-Seq_CD4+_Human1.26881055
67MYC_19829295_ChIP-Seq_ESCs_Human1.26662799
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.26220072
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26219247
70TCF4_23295773_ChIP-Seq_U87_Human1.26065839
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24752447
72SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21008755
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.19581092
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19382807
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18786457
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18590083
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18550296
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16530417
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15398948
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14166683
81CBP_20019798_ChIP-Seq_JUKART_Human1.13663040
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13663040
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12180404
84SOX2_19829295_ChIP-Seq_ESCs_Human1.11290567
85NANOG_19829295_ChIP-Seq_ESCs_Human1.11290567
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.10862082
87FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10448697
88P300_19829295_ChIP-Seq_ESCs_Human1.09686376
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09447132
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09424747
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08713448
92KDM5A_27292631_Chip-Seq_BREAST_Human1.08646736
93ZNF263_19887448_ChIP-Seq_K562_Human1.07346698
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06072359
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04651728
96KLF4_19829295_ChIP-Seq_ESCs_Human1.03613020
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03485377
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03357291
99GABP_19822575_ChIP-Seq_HepG2_Human1.03280677
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03077442
101ERG_20517297_ChIP-Seq_VCAP_Human1.02376419
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02320351
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01765606
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01067179
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00071704
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99988661
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98831600
108TP53_16413492_ChIP-PET_HCT116_Human0.98649754
109SOX2_21211035_ChIP-Seq_LN229_Human0.98506852
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97386765
111GATA3_26560356_Chip-Seq_TH2_Human0.96937346
112TCF4_22108803_ChIP-Seq_LS180_Human0.96278617
113FLI1_21867929_ChIP-Seq_CD8_Mouse0.95728234
114CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94942183
115HOXB7_26014856_ChIP-Seq_BT474_Human0.94932917
116CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94560242
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93071864
118RAC3_21632823_ChIP-Seq_H3396_Human0.92344891
119ERA_21632823_ChIP-Seq_H3396_Human0.92341838
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91934398
121CBP_21632823_ChIP-Seq_H3396_Human0.91260212
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.89787675
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89749764
124GF1_26923725_Chip-Seq_HPCs_Mouse0.89609647
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89526623
126DCP1A_22483619_ChIP-Seq_HELA_Human0.89510149
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88913258
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88612190
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88544350
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87646961
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.87513787
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.87135009
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.86376037
134GATA1_22025678_ChIP-Seq_K562_Human0.86362687
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84986649
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84405436
137STAT1_20625510_ChIP-Seq_HELA_Human0.84119830
138SMAD4_21799915_ChIP-Seq_A2780_Human0.84104523
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84096461
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84015234
141P53_21459846_ChIP-Seq_SAOS-2_Human0.83707711
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83211095
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.83188391
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82967491
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82613520
146BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.82596735
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82538429
148IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82292601
149SOX2_22085726_ChIP-Seq_NPCs_Mouse0.81952862
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81745713
151SMRT_27268052_Chip-Seq_Bcells_Human0.81273061
152ETV1_20927104_ChIP-Seq_GIST48_Human0.80086907
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79958971
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79853238
155TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.79302470
156FOXP3_21729870_ChIP-Seq_TREG_Human0.79141942
157SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79102490
158AR_20517297_ChIP-Seq_VCAP_Human0.78776101
159TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78289282
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78256051
161GATA3_26560356_Chip-Seq_TH1_Human0.78046348
162NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77857121
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77581984
164TAL1_26923725_Chip-Seq_HPCs_Mouse0.77371961
165HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77164311
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.76414154
167MYC_18555785_ChIP-Seq_MESCs_Mouse0.75817610
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75656977
169XRN2_22483619_ChIP-Seq_HELA_Human0.75629896
170PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75544446
171CRX_20693478_ChIP-Seq_RETINA_Mouse0.75382223
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75314661
173NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74932445
174MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74733507
175GF1B_26923725_Chip-Seq_HPCs_Mouse0.74658164
176ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73686372
177MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72201547
178GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.71750626
179KAP1_27257070_Chip-Seq_ESCs_Mouse0.71694610
180RBPJ_21746931_ChIP-Seq_IB4_Human0.71591499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.34568362
2MP0008877_abnormal_DNA_methylation5.96815687
3MP0003303_peritoneal_inflammation4.85593830
4MP0003693_abnormal_embryo_hatching4.71785804
5MP0003718_maternal_effect4.59596850
6MP0001929_abnormal_gametogenesis4.59249350
7MP0003698_abnormal_male_reproductive3.76215721
8MP0002210_abnormal_sex_determination3.65523240
9MP0010094_abnormal_chromosome_stability3.61966150
10MP0003111_abnormal_nucleus_morphology3.57412364
11MP0005058_abnormal_lysosome_morphology3.45209621
12MP0008057_abnormal_DNA_replication3.35883342
13MP0003077_abnormal_cell_cycle3.13836194
14MP0003646_muscle_fatigue3.07369787
15MP0000653_abnormal_sex_gland2.96725179
16MP0005451_abnormal_body_composition2.94791854
17MP0001145_abnormal_male_reproductive2.86819739
18MP0002161_abnormal_fertility/fecundity2.65590001
19MP0002139_abnormal_hepatobiliary_system2.54811635
20MP0004957_abnormal_blastocyst_morpholog2.52146917
21MP0002653_abnormal_ependyma_morphology2.36312195
22MP0008007_abnormal_cellular_replicative2.34224914
23MP0008058_abnormal_DNA_repair2.23093620
24MP0000678_abnormal_parathyroid_gland2.15175548
25MP0003123_paternal_imprinting2.14340007
26MP0008004_abnormal_stomach_pH1.96201866
27MP0003699_abnormal_female_reproductive1.92721814
28MP0003183_abnormal_peptide_metabolism1.89870273
29MP0001119_abnormal_female_reproductive1.89524625
30MP0005395_other_phenotype1.89210874
31MP0008789_abnormal_olfactory_epithelium1.88795890
32MP0000569_abnormal_digit_pigmentation1.81822915
33MP0006082_CNS_inflammation1.75864715
34MP0005167_abnormal_blood-brain_barrier1.75035256
35MP0010352_gastrointestinal_tract_polyps1.72242701
36MP0003786_premature_aging1.72136759
37MP0002102_abnormal_ear_morphology1.71155004
38MP0008932_abnormal_embryonic_tissue1.66815111
39MP0002160_abnormal_reproductive_system1.56327920
40MP0010307_abnormal_tumor_latency1.52904231
41MP0001730_embryonic_growth_arrest1.49214639
42MP0009840_abnormal_foam_cell1.47383134
43MP0005248_abnormal_Harderian_gland1.46854257
44MP0000465_gastrointestinal_hemorrhage1.46706076
45MP0005394_taste/olfaction_phenotype1.39800129
46MP0005499_abnormal_olfactory_system1.39800129
47MP0005389_reproductive_system_phenotype1.39095363
48MP0001986_abnormal_taste_sensitivity1.38554621
49MP0002148_abnormal_hypersensitivity_rea1.36237574
50MP0003868_abnormal_feces_composition1.34964665
51MP0008995_early_reproductive_senescence1.34017131
52MP0008260_abnormal_autophagy1.31621983
53MP0000350_abnormal_cell_proliferation1.26591738
54MP0001672_abnormal_embryogenesis/_devel1.24119521
55MP0005380_embryogenesis_phenotype1.24119521
56MP0003315_abnormal_perineum_morphology1.24072154
57MP0009785_altered_susceptibility_to1.23747833
58MP0000604_amyloidosis1.21185882
59MP0003121_genomic_imprinting1.15742941
60MP0004264_abnormal_extraembryonic_tissu1.14704764
61MP0002095_abnormal_skin_pigmentation1.12804990
62MP0005671_abnormal_response_to1.10161370
63MP0002419_abnormal_innate_immunity1.08791851
64MP0005647_abnormal_sex_gland1.06607468
65MP0003879_abnormal_hair_cell1.05090353
66MP0001697_abnormal_embryo_size1.03681634
67MP0003787_abnormal_imprinting1.01838678
68MP0005423_abnormal_somatic_nervous1.01527262
69MP0004782_abnormal_surfactant_physiolog0.95730896
70MP0003690_abnormal_glial_cell0.94999167
71MP0009764_decreased_sensitivity_to0.94762108
72MP0001486_abnormal_startle_reflex0.94431408
73MP0001919_abnormal_reproductive_system0.91029665
74MP0002085_abnormal_embryonic_tissue0.90822997
75MP0003890_abnormal_embryonic-extraembry0.88275256
76MP0003984_embryonic_growth_retardation0.87349411
77MP0003937_abnormal_limbs/digits/tail_de0.86023554
78MP0001835_abnormal_antigen_presentation0.84990744
79MP0002138_abnormal_hepatobiliary_system0.83717368
80MP0005310_abnormal_salivary_gland0.83566531
81MP0004233_abnormal_muscle_weight0.82901367
82MP0001661_extended_life_span0.82296576
83MP0002088_abnormal_embryonic_growth/wei0.82222172
84MP0002084_abnormal_developmental_patter0.81850259
85MP0002080_prenatal_lethality0.80577379
86MP0002723_abnormal_immune_serum0.79353648
87MP0005076_abnormal_cell_differentiation0.78850606
88MP0002452_abnormal_antigen_presenting0.78293683
89MP0000343_altered_response_to0.78229280
90MP0005000_abnormal_immune_tolerance0.77278298
91MP0000920_abnormal_myelination0.76904456
92MP0000313_abnormal_cell_death0.76889128
93MP0005025_abnormal_response_to0.76728829
94MP0004145_abnormal_muscle_electrophysio0.75992553
95MP0003724_increased_susceptibility_to0.75896810
96MP0003633_abnormal_nervous_system0.75531545
97MP0000579_abnormal_nail_morphology0.74097621
98MP0009278_abnormal_bone_marrow0.71411229
99MP0004885_abnormal_endolymph0.70924129
100MP0005360_urolithiasis0.70658346
101MP0002229_neurodegeneration0.68233941
102MP0005621_abnormal_cell_physiology0.67515616
103MP0005187_abnormal_penis_morphology0.67000331
104MP0004043_abnormal_pH_regulation0.66194823
105MP0002998_abnormal_bone_remodeling0.65726051
106MP0005377_hearing/vestibular/ear_phenot0.65201451
107MP0003878_abnormal_ear_physiology0.65201451
108MP0006292_abnormal_olfactory_placode0.64924358
109MP0005408_hypopigmentation0.64917996
110MP0009046_muscle_twitch0.64877538
111MP0001800_abnormal_humoral_immune0.63896069
112MP0000647_abnormal_sebaceous_gland0.63832780
113MP0003950_abnormal_plasma_membrane0.63567213
114MP0008469_abnormal_protein_level0.63539076
115MP0003448_altered_tumor_morphology0.63461685
116MP0001664_abnormal_digestion0.63364339
117MP0002019_abnormal_tumor_incidence0.61747158
118MP0005397_hematopoietic_system_phenotyp0.61205987
119MP0001545_abnormal_hematopoietic_system0.61205987
120MP0003195_calcinosis0.61061562
121MP0003329_amyloid_beta_deposits0.61020455
122MP0004134_abnormal_chest_morphology0.60161359
123MP0001790_abnormal_immune_system0.59475481
124MP0005387_immune_system_phenotype0.59475481
125MP0005384_cellular_phenotype0.58107382
126MP0003436_decreased_susceptibility_to0.57582917
127MP0003936_abnormal_reproductive_system0.57267169
128MP0004019_abnormal_vitamin_homeostasis0.57266643
129MP0002277_abnormal_respiratory_mucosa0.56221004
130MP0000427_abnormal_hair_cycle0.55822161
131MP0002086_abnormal_extraembryonic_tissu0.55295068
132MP0003075_altered_response_to0.54975747
133MP0002067_abnormal_sensory_capabilities0.54660089
134MP0002420_abnormal_adaptive_immunity0.53886815
135MP0001819_abnormal_immune_cell0.52941944
136MP0004510_myositis0.52621811
137MP0010386_abnormal_urinary_bladder0.52605418
138MP0000015_abnormal_ear_pigmentation0.52179858
139MP0001963_abnormal_hearing_physiology0.49345858
140MP0004808_abnormal_hematopoietic_stem0.48777665
141MP0001324_abnormal_eye_pigmentation0.48361364
142MP0009745_abnormal_behavioral_response0.48169808
143MP0000358_abnormal_cell_content/0.47962431
144MP0001905_abnormal_dopamine_level0.47839613
145MP0001501_abnormal_sleep_pattern0.47283876
146MP0000383_abnormal_hair_follicle0.47000053
147MP0001765_abnormal_ion_homeostasis0.44835343
148MP0000627_abnormal_mammary_gland0.44805627
149MP0009672_abnormal_birth_weight0.43198977
150MP0003763_abnormal_thymus_physiology0.42539773
151MP0009333_abnormal_splenocyte_physiolog0.42432897
152MP0003938_abnormal_ear_development0.39345828
153MP0003656_abnormal_erythrocyte_physiolo0.38907041
154MP0002877_abnormal_melanocyte_morpholog0.37823192
155MP0006072_abnormal_retinal_apoptosis0.36615459
156MP0003941_abnormal_skin_development0.35725208
157MP0005670_abnormal_white_adipose0.35706671
158MP0004036_abnormal_muscle_relaxation0.33891583
159MP0003191_abnormal_cellular_cholesterol0.31515598
160MP0000432_abnormal_head_morphology0.30165472
161MP0000462_abnormal_digestive_system0.30071780
162MP0005636_abnormal_mineral_homeostasis0.29603561
163MP0003453_abnormal_keratinocyte_physiol0.29185929
164MP0003861_abnormal_nervous_system0.28625427
165MP0002169_no_abnormal_phenotype0.28230915
166MP0002873_normal_phenotype0.27956038
167MP0001727_abnormal_embryo_implantation0.27468098
168MP0000001_mammalian_phenotype0.27266182

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)7.81783481
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.81783481
3Abnormal respiratory motile cilium physiology (HP:0012261)6.71477855
4Infertility (HP:0000789)6.02177314
5Rhinitis (HP:0012384)5.93327382
6Chronic bronchitis (HP:0004469)5.87370715
7Abnormal respiratory epithelium morphology (HP:0012253)5.66978822
8Abnormal respiratory motile cilium morphology (HP:0005938)5.66978822
9Male infertility (HP:0003251)5.55082351
10Loss of speech (HP:0002371)4.94468752
11Abnormal ciliary motility (HP:0012262)4.87521694
12Impulsivity (HP:0100710)4.51521534
13Disinhibition (HP:0000734)4.29363683
14Abnormality of glycolipid metabolism (HP:0010969)4.21474252
15Abnormality of liposaccharide metabolism (HP:0010968)4.21474252
16Abnormality of glycosphingolipid metabolism (HP:0004343)4.21474252
17Abnormal spermatogenesis (HP:0008669)4.17058207
18Medulloblastoma (HP:0002885)4.06568225
19Nasal polyposis (HP:0100582)4.05847291
20Prolonged neonatal jaundice (HP:0006579)3.91869920
21Papillary thyroid carcinoma (HP:0002895)3.87703265
22Birth length less than 3rd percentile (HP:0003561)3.73370225
23Breast hypoplasia (HP:0003187)3.65173368
24Retinal atrophy (HP:0001105)3.61727036
25Bronchiectasis (HP:0002110)3.59640425
26Azoospermia (HP:0000027)3.58690386
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52008074
28Stomach cancer (HP:0012126)3.47301107
29Neurofibrillary tangles (HP:0002185)3.46309717
30Chromsome breakage (HP:0040012)3.40316669
31Colon cancer (HP:0003003)3.37217377
32Glioma (HP:0009733)3.31867743
33Hypoplasia of the capital femoral epiphysis (HP:0003090)3.28229543
34Mutism (HP:0002300)3.26195911
35Vacuolated lymphocytes (HP:0001922)3.21412530
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.18111268
37Tubulointerstitial nephritis (HP:0001970)3.17848404
38Abnormality of macrophages (HP:0004311)3.16061120
39Nephronophthisis (HP:0000090)3.11396079
40Abnormality of the nasal mucosa (HP:0000433)3.11221957
41Hepatoblastoma (HP:0002884)3.09340905
42Degeneration of the lateral corticospinal tracts (HP:0002314)3.08754698
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08754698
44Inappropriate behavior (HP:0000719)3.08449150
45Bronchitis (HP:0012387)3.08000687
46Premature ovarian failure (HP:0008209)2.96271465
47Apathy (HP:0000741)2.94148241
48Neoplasm of the adrenal cortex (HP:0100641)2.92289285
49Patellar aplasia (HP:0006443)2.86159773
50Global brain atrophy (HP:0002283)2.84641416
51Secondary amenorrhea (HP:0000869)2.82403957
52Epidermoid cyst (HP:0200040)2.82213967
53Carpal bone hypoplasia (HP:0001498)2.79871749
54Neurodegeneration (HP:0002180)2.79152348
55Degeneration of anterior horn cells (HP:0002398)2.77351784
56Abnormality of the anterior horn cell (HP:0006802)2.77351784
57Diminished motivation (HP:0000745)2.76511027
58Aplasia/Hypoplasia of the patella (HP:0006498)2.73759161
59Volvulus (HP:0002580)2.66610287
60Osteomalacia (HP:0002749)2.64643590
61Rhabdomyosarcoma (HP:0002859)2.60036516
62Leiomyosarcoma (HP:0100243)2.60019995
63Uterine leiomyosarcoma (HP:0002891)2.60019995
64Subacute progressive viral hepatitis (HP:0006572)2.59298601
65Abnormality of the preputium (HP:0100587)2.56696420
66Molar tooth sign on MRI (HP:0002419)2.56209979
67Abnormality of midbrain morphology (HP:0002418)2.56209979
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54946458
69Absent epiphyses (HP:0010577)2.54946458
70Abnormality of the lower motor neuron (HP:0002366)2.54078418
71Axonal loss (HP:0003447)2.52152459
72Gonadotropin excess (HP:0000837)2.50539722
73Neuronal loss in central nervous system (HP:0002529)2.49063455
74B lymphocytopenia (HP:0010976)2.42290348
75Metaphyseal irregularity (HP:0003025)2.42123724
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39490812
77Meckel diverticulum (HP:0002245)2.38488592
78Supernumerary spleens (HP:0009799)2.38288240
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.37700930
80Hypokinesia (HP:0002375)2.34724278
81Insulin-resistant diabetes mellitus (HP:0000831)2.34517730
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.33053402
83Abnormality of chromosome stability (HP:0003220)2.30549343
84Poor eye contact (HP:0000817)2.28659835
85Recurrent pneumonia (HP:0006532)2.28559214
86Thyroid carcinoma (HP:0002890)2.28545026
87Abnormality of the renal medulla (HP:0100957)2.28414170
88Abnormality of the ileum (HP:0001549)2.26860127
89Shoulder girdle muscle weakness (HP:0003547)2.24775359
90Pancreatic fibrosis (HP:0100732)2.24639526
91Fair hair (HP:0002286)2.21612070
92Systemic lupus erythematosus (HP:0002725)2.20118377
93Recurrent otitis media (HP:0000403)2.17515306
94Amyotrophic lateral sclerosis (HP:0007354)2.17055761
95Agnosia (HP:0010524)2.15774943
96Abnormality of the basal ganglia (HP:0002134)2.15712496
97Abnormality of the astrocytes (HP:0100707)2.14594796
98Astrocytoma (HP:0009592)2.14594796
99Neoplasm of the oral cavity (HP:0100649)2.13584447
100Abnormality of B cell number (HP:0010975)2.13373127
101Facial hemangioma (HP:0000329)2.09878161
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09496341
103Dementia (HP:0000726)2.08044089
104Upper limb muscle weakness (HP:0003484)2.07199007
105Protruding tongue (HP:0010808)2.05535975
106Short nail (HP:0001799)2.05477013
107Malnutrition (HP:0004395)2.05302560
108Abnormality of chromosome segregation (HP:0002916)2.04303142
109Oligodactyly (hands) (HP:0001180)2.04246206
110Abnormality of the corticospinal tract (HP:0002492)2.02915773
111Cerebral hypomyelination (HP:0006808)2.00528458
112Supranuclear gaze palsy (HP:0000605)2.00307595
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.0611478
114Sloping forehead (HP:0000340)1.98768090
115Impaired vibration sensation in the lower limbs (HP:0002166)1.98567935
116Small intestinal stenosis (HP:0012848)1.98408439
117Duodenal stenosis (HP:0100867)1.98408439
118Ureteral duplication (HP:0000073)1.98063423
119Horizontal nystagmus (HP:0000666)1.96367685
120Transitional cell carcinoma of the bladder (HP:0006740)1.96361737
121Abnormality of the labia minora (HP:0012880)1.95105842
122Anterior segment dysgenesis (HP:0007700)1.94954457
123Breast carcinoma (HP:0003002)1.94310609
124Micronodular cirrhosis (HP:0001413)1.93435347
125Nephroblastoma (Wilms tumor) (HP:0002667)1.92879052
126Flat capital femoral epiphysis (HP:0003370)1.92609886
127Poor head control (HP:0002421)1.92192121
128Hypergonadotropic hypogonadism (HP:0000815)1.90923410
129Acute myeloid leukemia (HP:0004808)1.88977257
130Multiple lipomas (HP:0001012)1.88867261
131Increased cerebral lipofuscin (HP:0011813)1.87575124
132Conjunctival telangiectasia (HP:0000524)1.86688358
133Upper motor neuron abnormality (HP:0002127)1.85780023
134Entropion (HP:0000621)1.85716108
135Spastic tetraparesis (HP:0001285)1.85521311
136Capillary hemangiomas (HP:0005306)1.84535398
137Tubulointerstitial abnormality (HP:0001969)1.84137146
138Gout (HP:0001997)1.83109282
139Glucose intolerance (HP:0000833)1.82489168
140Cerebral inclusion bodies (HP:0100314)1.82423718
141Prostate neoplasm (HP:0100787)1.82154936
142Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81889494
143Personality changes (HP:0000751)1.81870950
144Bladder neoplasm (HP:0009725)1.81660989
145Bladder carcinoma (HP:0002862)1.81660989
146Recurrent bacterial skin infections (HP:0005406)1.81112629
147Cleft eyelid (HP:0000625)1.80305554
148Abnormality of the epiphysis of the femoral head (HP:0010574)1.80021950
149Flat occiput (HP:0005469)1.79358773
150Non-midline cleft lip (HP:0100335)1.79078433
151Memory impairment (HP:0002354)1.78162570
152Sandal gap (HP:0001852)1.76708002
153Clubbing of toes (HP:0100760)1.76564376
154Hyperglycinemia (HP:0002154)1.76082727
155Embryonal renal neoplasm (HP:0011794)1.74588458
156Breast aplasia (HP:0100783)1.74284773
157Dysostosis multiplex (HP:0000943)1.73938991
158Tetraplegia (HP:0002445)1.73200467
159Aplasia/Hypoplasia of the breasts (HP:0010311)1.72674769
160Ectopic kidney (HP:0000086)1.71440451
161Viral hepatitis (HP:0006562)1.71382844
162Abnormality of the femoral head (HP:0003368)1.71336244
163Pancreatic cysts (HP:0001737)1.71042338
164Widely spaced teeth (HP:0000687)1.70699836
165Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70607509
166Acute hepatic failure (HP:0006554)1.70344865
167Bundle branch block (HP:0011710)1.69911808
168Medial flaring of the eyebrow (HP:0010747)1.69047888
169Shawl scrotum (HP:0000049)1.68254545
170Recurrent sinusitis (HP:0011108)1.67433009
171Cortical dysplasia (HP:0002539)1.67317894
172Short thumb (HP:0009778)1.66357500
173Oligodactyly (HP:0012165)1.66088299
174Type 2 muscle fiber atrophy (HP:0003554)1.65242415
175Abnormality of lateral ventricle (HP:0030047)1.64816299
176Microglossia (HP:0000171)1.63869503
177Delayed epiphyseal ossification (HP:0002663)1.61827802
178Abnormality of femoral epiphyses (HP:0006499)1.60131825
179Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.60131825
180Spontaneous abortion (HP:0005268)1.60105868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.65623361
2PDK45.65623361
3CDK194.26803459
4PDK23.76668351
5PLK43.37925216
6TTK3.33972583
7BUB13.17126296
8NEK23.16715641
9PRKD33.02490062
10CAMK1G2.58746950
11BRSK22.53696031
12CDC72.40093773
13NEK92.36403288
14STK38L2.33659970
15LATS22.17988501
16CSNK1G32.11087382
17STK32.08947938
18MET2.01464765
19WEE11.98071125
20BRAF1.95772731
21CHEK21.94114472
22CSNK1A1L1.94093614
23PLK11.88337294
24FGR1.83889021
25CASK1.81718054
26GRK71.81594322
27MAP3K61.72373892
28CSNK1G21.67139558
29LATS11.63452290
30ACVR1B1.60804083
31EIF2AK11.53751828
32BMPR21.53043122
33TESK11.52690289
34TNIK1.52627546
35CDK121.51491352
36SRPK11.51383349
37MOS1.46524550
38CSF1R1.41253691
39TAOK31.37695520
40BMPR1B1.34769303
41OXSR11.32029084
42BRSK11.31869555
43STK161.31373658
44MUSK1.21985108
45DYRK31.20246984
46ICK1.15452241
47AURKB1.13684458
48STK101.10291023
49CHEK11.09393167
50ARAF1.09368279
51PLK31.07519828
52CAMK1D1.06594123
53STK381.06251092
54AURKA1.03163293
55CCNB11.03088902
56WNK41.00511893
57BLK0.97241181
58PLK20.95201547
59ERBB40.94553280
60TAOK20.93125255
61ZAK0.90199474
62PNCK0.89660693
63PRKAA10.89551928
64MATK0.88713071
65AKT30.86907174
66IRAK30.84490691
67PINK10.81204466
68TGFBR20.80667055
69DDR20.80181645
70IKBKE0.78939416
71MAP3K90.78650267
72STK390.78266208
73RPS6KA40.78263264
74PKN10.77921500
75IRAK40.76553624
76TESK20.74686862
77JAK30.74570266
78CAMKK20.74448090
79ATR0.74257096
80IKBKB0.74230619
81KSR20.73847675
82PDPK10.73729917
83NTRK30.73396456
84TYK20.72719353
85ATM0.71233566
86PTK2B0.70574026
87DYRK20.69196271
88MAP3K140.69039720
89MELK0.68917956
90CDK30.68317595
91MAP3K30.65892269
92STK240.64623139
93RAF10.63132531
94TBK10.61876464
95TYRO30.61725754
96CDK70.61651325
97TAOK10.61137428
98EGFR0.60034318
99BMX0.59355940
100CAMK10.58946312
101EEF2K0.58567860
102PRKG10.56617507
103CSK0.56478974
104MAP3K110.56303768
105MAP3K80.54364684
106KSR10.54282329
107ADRBK20.53944165
108PAK10.53901908
109CDK40.53040589
110CDK20.51008148
111TGFBR10.50988229
112NUAK10.49312663
113IGF1R0.49303739
114NME20.48582694
115NEK60.44966761
116MAP3K50.43980597
117ABL20.43017539
118MAP2K10.42990545
119BCR0.42792172
120CDK10.42470394
121DAPK20.41753052
122PAK60.39109605
123MKNK20.38742171
124MAP3K10.38301098
125PIM10.38162435
126PDK10.37159768
127CDK11A0.37144482
128MAP2K70.36702558
129CSNK1G10.36528366
130CAMKK10.34973560
131INSRR0.32510728
132CHUK0.32113420
133MAP3K40.31970742
134CDK90.31802975
135EPHA20.31575400
136VRK10.31526870
137WNK10.31400802
138DMPK0.31152441
139MAPK110.29941025
140CSNK1E0.29899397
141MTOR0.29570483
142MAPK150.26769582
143CSNK1D0.25683720
144SGK10.25364840
145CSNK1A10.24583560
146EIF2AK20.22243005
147CDK80.21995760
148PRKCI0.21721092
149STK40.21455051
150RPS6KB10.21095536
151EIF2AK30.20893687
152RPS6KA10.20829437
153IRAK10.19698139
154CSNK2A10.18667295
155MARK30.17954415
156NLK0.17221405
157PRKAA20.17157025
158MAP3K130.17141370
159MAPK100.17102490
160MAPKAPK50.15837124

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.10303922
2Basal transcription factors_Homo sapiens_hsa030224.00210857
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.81177801
4RNA polymerase_Homo sapiens_hsa030203.50544560
5Fanconi anemia pathway_Homo sapiens_hsa034603.41669013
6Cell cycle_Homo sapiens_hsa041103.22661984
7RNA transport_Homo sapiens_hsa030132.99812514
8Lysosome_Homo sapiens_hsa041422.91802019
9Rheumatoid arthritis_Homo sapiens_hsa053232.61645164
10Homologous recombination_Homo sapiens_hsa034402.61037614
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.52568150
12Oocyte meiosis_Homo sapiens_hsa041142.52372198
13Asthma_Homo sapiens_hsa053102.27490995
14Sulfur relay system_Homo sapiens_hsa041222.22437349
15RNA degradation_Homo sapiens_hsa030182.21886931
16p53 signaling pathway_Homo sapiens_hsa041152.10169407
17Staphylococcus aureus infection_Homo sapiens_hsa051502.05882536
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03719503
19Linoleic acid metabolism_Homo sapiens_hsa005912.03372845
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01859906
21Collecting duct acid secretion_Homo sapiens_hsa049662.00009883
22Dorso-ventral axis formation_Homo sapiens_hsa043201.99437814
23Pyrimidine metabolism_Homo sapiens_hsa002401.85153956
24Osteoclast differentiation_Homo sapiens_hsa043801.84734345
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.83863676
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73942860
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72127983
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71396768
29Allograft rejection_Homo sapiens_hsa053301.71157216
30Circadian rhythm_Homo sapiens_hsa047101.70061874
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.69260661
32DNA replication_Homo sapiens_hsa030301.67919806
33Purine metabolism_Homo sapiens_hsa002301.67694363
34Leishmaniasis_Homo sapiens_hsa051401.65945891
35Pentose phosphate pathway_Homo sapiens_hsa000301.65292591
36Legionellosis_Homo sapiens_hsa051341.59937818
37mRNA surveillance pathway_Homo sapiens_hsa030151.59712203
38Tuberculosis_Homo sapiens_hsa051521.58393036
39Phagosome_Homo sapiens_hsa041451.56458009
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51727629
41Mismatch repair_Homo sapiens_hsa034301.45236328
42Ether lipid metabolism_Homo sapiens_hsa005651.36313654
43Autoimmune thyroid disease_Homo sapiens_hsa053201.35803941
44Nucleotide excision repair_Homo sapiens_hsa034201.35371603
45Graft-versus-host disease_Homo sapiens_hsa053321.33579979
46ABC transporters_Homo sapiens_hsa020101.30223514
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29261457
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28616289
49Base excision repair_Homo sapiens_hsa034101.26188970
50Spliceosome_Homo sapiens_hsa030401.24050404
51Pertussis_Homo sapiens_hsa051331.18696529
52Regulation of autophagy_Homo sapiens_hsa041401.12762622
53Selenocompound metabolism_Homo sapiens_hsa004501.12037508
54Proteasome_Homo sapiens_hsa030501.11360268
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11159680
56African trypanosomiasis_Homo sapiens_hsa051431.10725216
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09428243
58TNF signaling pathway_Homo sapiens_hsa046681.07848504
59Ovarian steroidogenesis_Homo sapiens_hsa049131.07095616
60Malaria_Homo sapiens_hsa051441.06811810
61Folate biosynthesis_Homo sapiens_hsa007901.04764309
62Non-homologous end-joining_Homo sapiens_hsa034501.02098477
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00906898
64Epstein-Barr virus infection_Homo sapiens_hsa051691.00514926
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98263410
66Olfactory transduction_Homo sapiens_hsa047400.98028966
67Toxoplasmosis_Homo sapiens_hsa051450.96288204
68Synaptic vesicle cycle_Homo sapiens_hsa047210.95241456
69Pyruvate metabolism_Homo sapiens_hsa006200.92815654
70Prion diseases_Homo sapiens_hsa050200.91956355
71Arachidonic acid metabolism_Homo sapiens_hsa005900.87566087
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87441772
73Glucagon signaling pathway_Homo sapiens_hsa049220.85599148
74Chemokine signaling pathway_Homo sapiens_hsa040620.85578583
75Vitamin digestion and absorption_Homo sapiens_hsa049770.82991312
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81843581
77Glycerolipid metabolism_Homo sapiens_hsa005610.81000478
78Fatty acid elongation_Homo sapiens_hsa000620.80879285
79Type I diabetes mellitus_Homo sapiens_hsa049400.78081382
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77647271
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75925046
82Salmonella infection_Homo sapiens_hsa051320.73311421
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73112810
84Hematopoietic cell lineage_Homo sapiens_hsa046400.71880381
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69024000
86Herpes simplex infection_Homo sapiens_hsa051680.66589775
87Thyroid cancer_Homo sapiens_hsa052160.65297348
88Antigen processing and presentation_Homo sapiens_hsa046120.62075467
89Fatty acid biosynthesis_Homo sapiens_hsa000610.60789924
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57632845
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.57518612
92mTOR signaling pathway_Homo sapiens_hsa041500.56330617
93Sphingolipid metabolism_Homo sapiens_hsa006000.56119649
94Influenza A_Homo sapiens_hsa051640.53433735
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.50670811
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50226379
97HTLV-I infection_Homo sapiens_hsa051660.49490320
98MicroRNAs in cancer_Homo sapiens_hsa052060.47923030
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47734879
100B cell receptor signaling pathway_Homo sapiens_hsa046620.47094567
101Biosynthesis of amino acids_Homo sapiens_hsa012300.46605894
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43178244
103Viral myocarditis_Homo sapiens_hsa054160.41875435
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41691341
105PPAR signaling pathway_Homo sapiens_hsa033200.40704663
106Glutathione metabolism_Homo sapiens_hsa004800.40284248
107Inositol phosphate metabolism_Homo sapiens_hsa005620.40169872
108Amoebiasis_Homo sapiens_hsa051460.39910309
109Prolactin signaling pathway_Homo sapiens_hsa049170.39604539
110Hedgehog signaling pathway_Homo sapiens_hsa043400.36175717
111FoxO signaling pathway_Homo sapiens_hsa040680.35836860
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35412856
113Hepatitis B_Homo sapiens_hsa051610.34664062
114Huntingtons disease_Homo sapiens_hsa050160.33934204
115Propanoate metabolism_Homo sapiens_hsa006400.33806338
116Other glycan degradation_Homo sapiens_hsa005110.33639255
117Fructose and mannose metabolism_Homo sapiens_hsa000510.32024009
118Viral carcinogenesis_Homo sapiens_hsa052030.31404398
119Acute myeloid leukemia_Homo sapiens_hsa052210.31063884
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31026189
121Choline metabolism in cancer_Homo sapiens_hsa052310.30594800
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.30261770
123MAPK signaling pathway_Homo sapiens_hsa040100.29258047
124VEGF signaling pathway_Homo sapiens_hsa043700.29089812
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29018905
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29006488
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28662916
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28425140
129Oxytocin signaling pathway_Homo sapiens_hsa049210.28032373
130Apoptosis_Homo sapiens_hsa042100.27977876
131Mineral absorption_Homo sapiens_hsa049780.26586452
132TGF-beta signaling pathway_Homo sapiens_hsa043500.26136225
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.25499039
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24359377
135Metabolic pathways_Homo sapiens_hsa011000.23731597
136Measles_Homo sapiens_hsa051620.23604611
137Pancreatic cancer_Homo sapiens_hsa052120.23251469
138beta-Alanine metabolism_Homo sapiens_hsa004100.23231469
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22228013
140Hippo signaling pathway_Homo sapiens_hsa043900.21686821
141Small cell lung cancer_Homo sapiens_hsa052220.21644447
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19727963
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.18580194
144AMPK signaling pathway_Homo sapiens_hsa041520.18008397
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17639754
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16235944
147Renal cell carcinoma_Homo sapiens_hsa052110.15600107
148Estrogen signaling pathway_Homo sapiens_hsa049150.14203313
149Wnt signaling pathway_Homo sapiens_hsa043100.13517992
150Prostate cancer_Homo sapiens_hsa052150.12980344
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.12673640
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11988243
153Amphetamine addiction_Homo sapiens_hsa050310.08539021
154NF-kappa B signaling pathway_Homo sapiens_hsa040640.07358646
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.05266338
156Shigellosis_Homo sapiens_hsa051310.04925629
157Endometrial cancer_Homo sapiens_hsa052130.01492020

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