MEIOB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* synapsis (GO:0007129)9.47243509
2* chromosome organization involved in meiosis (GO:0070192)7.76353105
3DNA synthesis involved in DNA repair (GO:0000731)7.50853327
4L-phenylalanine catabolic process (GO:0006559)7.30817233
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30817233
6L-phenylalanine metabolic process (GO:0006558)6.98721260
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.98721260
8nuclear pore complex assembly (GO:0051292)6.94989879
9synaptonemal complex assembly (GO:0007130)6.83553249
10piRNA metabolic process (GO:0034587)6.75886615
11aromatic amino acid family catabolic process (GO:0009074)6.70616691
12DNA methylation involved in gamete generation (GO:0043046)6.52773434
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.39131567
14tryptophan catabolic process (GO:0006569)6.20457386
15indole-containing compound catabolic process (GO:0042436)6.20457386
16indolalkylamine catabolic process (GO:0046218)6.20457386
17synaptonemal complex organization (GO:0070193)6.10347664
18kynurenine metabolic process (GO:0070189)6.07531915
19nuclear pore organization (GO:0006999)6.06328371
20bile acid biosynthetic process (GO:0006699)5.97056214
21tryptophan metabolic process (GO:0006568)5.80623154
22meiotic chromosome segregation (GO:0045132)5.75869731
23* male meiosis I (GO:0007141)5.73974658
24glyoxylate metabolic process (GO:0046487)5.69741974
25urea metabolic process (GO:0019627)5.64157381
26urea cycle (GO:0000050)5.64157381
27negative regulation of fibrinolysis (GO:0051918)5.62916052
28high-density lipoprotein particle remodeling (GO:0034375)5.61861119
29complement activation, alternative pathway (GO:0006957)5.61825794
30regulation of protein activation cascade (GO:2000257)5.57050298
31alpha-linolenic acid metabolic process (GO:0036109)5.55524829
32protein carboxylation (GO:0018214)5.53833530
33peptidyl-glutamic acid carboxylation (GO:0017187)5.53833530
34* male meiosis (GO:0007140)5.52553139
35regulation of fibrinolysis (GO:0051917)5.45962502
36cysteine metabolic process (GO:0006534)5.28839849
37pore complex assembly (GO:0046931)5.23895754
38regulation of complement activation (GO:0030449)5.21220146
39nitrogen cycle metabolic process (GO:0071941)5.17530309
40sulfur amino acid catabolic process (GO:0000098)5.11811642
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.09951692
42* meiotic nuclear division (GO:0007126)5.09287390
43bile acid metabolic process (GO:0008206)5.09118796
44regulation of meiosis I (GO:0060631)5.07958218
45serine family amino acid catabolic process (GO:0009071)5.06771646
46regulation of cholesterol esterification (GO:0010872)4.95138265
47* meiotic cell cycle process (GO:1903046)4.87648295
48aromatic amino acid family metabolic process (GO:0009072)4.86515569
49reverse cholesterol transport (GO:0043691)4.84802901
50protein-lipid complex remodeling (GO:0034368)4.81283928
51macromolecular complex remodeling (GO:0034367)4.81283928
52plasma lipoprotein particle remodeling (GO:0034369)4.81283928
53regulation of triglyceride catabolic process (GO:0010896)4.80342820
54homocysteine metabolic process (GO:0050667)4.77819379
55* meiosis I (GO:0007127)4.76767193
56phospholipid efflux (GO:0033700)4.75870048
57sister chromatid cohesion (GO:0007062)4.75489249
58negative regulation of cholesterol transport (GO:0032375)4.69871845
59negative regulation of sterol transport (GO:0032372)4.69871845
60lysine metabolic process (GO:0006553)4.69786663
61lysine catabolic process (GO:0006554)4.69786663
62DNA replication checkpoint (GO:0000076)4.69344302
63amino-acid betaine metabolic process (GO:0006577)4.68975558
64triglyceride homeostasis (GO:0070328)4.66774470
65acylglycerol homeostasis (GO:0055090)4.66774470
66mitotic chromosome condensation (GO:0007076)4.59433944
67alpha-amino acid catabolic process (GO:1901606)4.57593149
68tyrosine metabolic process (GO:0006570)4.56946510
69plasma lipoprotein particle clearance (GO:0034381)4.45058742
70bile acid and bile salt transport (GO:0015721)4.44641546
71mitotic sister chromatid cohesion (GO:0007064)4.43345251
72reciprocal meiotic recombination (GO:0007131)4.39527611
73reciprocal DNA recombination (GO:0035825)4.39527611
74regulation of translational fidelity (GO:0006450)4.39311226
75imidazole-containing compound metabolic process (GO:0052803)4.38063920
76indolalkylamine metabolic process (GO:0006586)4.33676635
77coenzyme catabolic process (GO:0009109)4.32242836
78glycine metabolic process (GO:0006544)4.30583182
79cellular ketone body metabolic process (GO:0046950)4.29228699
80cellular biogenic amine catabolic process (GO:0042402)4.27347054
81amine catabolic process (GO:0009310)4.27347054
82mitotic sister chromatid segregation (GO:0000070)4.26747353
83cholesterol efflux (GO:0033344)4.24623992
84DNA unwinding involved in DNA replication (GO:0006268)4.23780669
85sister chromatid segregation (GO:0000819)4.22551098
86mitotic nuclear envelope disassembly (GO:0007077)4.19193096
87cellular amino acid catabolic process (GO:0009063)4.19116865
88benzene-containing compound metabolic process (GO:0042537)4.17797260
89DNA replication initiation (GO:0006270)4.17328528
90cellular glucuronidation (GO:0052695)4.16353891
91fibrinolysis (GO:0042730)4.15715319
92serine family amino acid metabolic process (GO:0009069)4.10989555
93ethanol oxidation (GO:0006069)4.07689062
94glutamate metabolic process (GO:0006536)4.07550179
95plasma lipoprotein particle assembly (GO:0034377)4.06100904
96low-density lipoprotein particle remodeling (GO:0034374)4.01453307
97blood coagulation, intrinsic pathway (GO:0007597)3.95515164
98very-low-density lipoprotein particle assembly (GO:0034379)3.94728449
99nuclear envelope disassembly (GO:0051081)3.93742833
100membrane disassembly (GO:0030397)3.93742833
101complement activation, classical pathway (GO:0006958)3.91595702
102negative regulation of lipase activity (GO:0060192)3.90621910
103arginine metabolic process (GO:0006525)3.90438102
104gene silencing by RNA (GO:0031047)3.90208946
105complement activation (GO:0006956)3.88870677
106diterpenoid biosynthetic process (GO:0016102)3.87514726
107drug catabolic process (GO:0042737)3.85930503
108serine family amino acid biosynthetic process (GO:0009070)3.85921526
109DNA topological change (GO:0006265)3.85504078
110dicarboxylic acid biosynthetic process (GO:0043650)3.84924304
111protein activation cascade (GO:0072376)3.83832554
112regulation of DNA endoreduplication (GO:0032875)3.83645681
113acute-phase response (GO:0006953)3.80810387
114positive regulation of lipid catabolic process (GO:0050996)3.79325629
115opsonization (GO:0008228)3.78923662
116cellular modified amino acid catabolic process (GO:0042219)3.78113437
117aldehyde catabolic process (GO:0046185)3.77249160
118cofactor catabolic process (GO:0051187)3.76916450
119* resolution of meiotic recombination intermediates (GO:0000712)3.74312470
120positive regulation of triglyceride lipase activity (GO:0061365)3.73707607
121positive regulation of lipoprotein lipase activity (GO:0051006)3.73707607
122short-chain fatty acid metabolic process (GO:0046459)3.72227041
123cytolysis (GO:0019835)3.71433310
124microtubule depolymerization (GO:0007019)3.70762479
125carboxylic acid catabolic process (GO:0046395)3.70364866
126organic acid catabolic process (GO:0016054)3.70364866
127ketone body metabolic process (GO:1902224)3.69637137
128cholesterol homeostasis (GO:0042632)3.68787465
129glucuronate metabolic process (GO:0019585)3.66805644
130uronic acid metabolic process (GO:0006063)3.66805644
131plasma lipoprotein particle organization (GO:0071827)3.63919958
132sterol homeostasis (GO:0055092)3.62406815
133DNA packaging (GO:0006323)3.62130186
134NAD biosynthetic process (GO:0009435)3.62067099
135heme transport (GO:0015886)3.61951956
136nicotinamide nucleotide biosynthetic process (GO:0019359)3.61320530
137pyridine nucleotide biosynthetic process (GO:0019363)3.61320530
138protein-lipid complex assembly (GO:0065005)3.60257373
139formation of translation preinitiation complex (GO:0001731)3.59328054
140kinetochore organization (GO:0051383)3.54683888
141DNA strand elongation involved in DNA replication (GO:0006271)3.53302291
142mitotic metaphase plate congression (GO:0007080)3.52558216
143chromosome segregation (GO:0007059)3.51935229
144regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48947738
145histone exchange (GO:0043486)3.48760669
146mitotic spindle assembly checkpoint (GO:0007094)3.46163490
147DNA strand elongation (GO:0022616)3.44162477
148mitotic spindle checkpoint (GO:0071174)3.43924325
149regulation of histone H3-K4 methylation (GO:0051569)3.38609263
150spindle assembly checkpoint (GO:0071173)3.38404343
151histone H2A acetylation (GO:0043968)3.34303410
152negative regulation of chromosome segregation (GO:0051985)3.33677152
153negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33609949
154negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33609949
155negative regulation of mitotic sister chromatid separation (GO:2000816)3.33609949
156negative regulation of sister chromatid segregation (GO:0033046)3.33609949
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33609949
158regulation of histone H3-K9 methylation (GO:0051570)3.32511145
159metaphase plate congression (GO:0051310)3.32419847
160protein localization to chromosome (GO:0034502)3.32157959
161* chromosome organization (GO:0051276)3.31799331
162telomere maintenance via semi-conservative replication (GO:0032201)3.30938215
163regulation of RNA export from nucleus (GO:0046831)3.30137942
164CENP-A containing nucleosome assembly (GO:0034080)3.28616381
165regulation of chromosome segregation (GO:0051983)3.27363915
166regulation of centriole replication (GO:0046599)3.19475988
167chromosome condensation (GO:0030261)3.18954812
168IMP biosynthetic process (GO:0006188)3.17906988
169spindle checkpoint (GO:0031577)3.14948025
170chromatin remodeling at centromere (GO:0031055)3.13777731
171proteasome assembly (GO:0043248)3.11715396
172purine nucleobase biosynthetic process (GO:0009113)3.11524790
173mismatch repair (GO:0006298)3.11055428
174protein localization to kinetochore (GO:0034501)3.09476503
175regulation of centrosome cycle (GO:0046605)3.09230123
176folic acid-containing compound biosynthetic process (GO:0009396)3.04971863
177histone H3-K9 demethylation (GO:0033169)3.03767543
178regulation of mitotic spindle organization (GO:0060236)3.02460607
179DNA replication-independent nucleosome organization (GO:0034724)3.02312104
180DNA replication-independent nucleosome assembly (GO:0006336)3.02312104
181regulation of histone H3-K27 methylation (GO:0061085)3.02206982
182DNA methylation (GO:0006306)3.01519880
183DNA alkylation (GO:0006305)3.01519880
184protoporphyrinogen IX metabolic process (GO:0046501)3.00363587
185terpenoid biosynthetic process (GO:0016114)3.00311508
186regulation of sister chromatid segregation (GO:0033045)2.99255763
187regulation of mitotic sister chromatid separation (GO:0010965)2.99255763
188regulation of mitotic sister chromatid segregation (GO:0033047)2.99255763
189DNA conformation change (GO:0071103)2.97365985
190regulation of histone methylation (GO:0031060)2.97120349
191attachment of spindle microtubules to kinetochore (GO:0008608)2.96033435
192mitotic recombination (GO:0006312)2.95218824
193somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92504434
194somatic hypermutation of immunoglobulin genes (GO:0016446)2.92504434
195protein localization to chromosome, centromeric region (GO:0071459)2.91630450
196regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90525355
197regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90525355
198regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90264876
199vitamin A metabolic process (GO:0006776)2.89414163
200DNA biosynthetic process (GO:0071897)2.87831255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.26032672
2E2F7_22180533_ChIP-Seq_HELA_Human8.22753381
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.29064508
4PPARA_22158963_ChIP-Seq_LIVER_Mouse7.10772900
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.41203309
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14162413
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03165620
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89643459
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.62846354
10FOXM1_23109430_ChIP-Seq_U2OS_Human4.35433849
11E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21673589
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94698035
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92480307
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58107385
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33170532
16MYC_18555785_ChIP-Seq_MESCs_Mouse3.33017391
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72661574
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65260494
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.60298233
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52558388
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50759445
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.45592508
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.44658414
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44592227
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40667805
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.37370624
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.35956148
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30664895
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.29361091
30DCP1A_22483619_ChIP-Seq_HELA_Human2.29235981
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28419717
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28232237
33MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24724305
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.22425202
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.10639984
36MYCN_18555785_ChIP-Seq_MESCs_Mouse2.10085778
37RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03713028
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7989474
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99192176
40XRN2_22483619_ChIP-Seq_HELA_Human1.98901351
41TTF2_22483619_ChIP-Seq_HELA_Human1.98005173
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95229270
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94836347
44ELK1_19687146_ChIP-ChIP_HELA_Human1.93235673
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87027887
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86262600
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86062824
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84556042
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84321901
50VDR_23849224_ChIP-Seq_CD4+_Human1.83837924
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80797660
52NCOR1_26117541_ChIP-Seq_K562_Human1.80400172
53FOXP3_21729870_ChIP-Seq_TREG_Human1.75555807
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.74462721
55KDM5A_27292631_Chip-Seq_BREAST_Human1.70287807
56GABP_19822575_ChIP-Seq_HepG2_Human1.67686339
57AR_21909140_ChIP-Seq_LNCAP_Human1.63893039
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62459636
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59979911
60HTT_18923047_ChIP-ChIP_STHdh_Human1.58789648
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57174653
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.53219488
63VDR_22108803_ChIP-Seq_LS180_Human1.52114779
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51109762
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47279454
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.46110638
67HNF4A_19822575_ChIP-Seq_HepG2_Human1.37545276
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32876467
69GATA1_22025678_ChIP-Seq_K562_Human1.31173574
70CIITA_25753668_ChIP-Seq_RAJI_Human1.29574467
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29201648
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28808869
73CLOCK_20551151_ChIP-Seq_293T_Human1.27835689
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19072686
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17841793
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17804942
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.14050600
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13387794
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12398885
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11634827
81MYC_18940864_ChIP-ChIP_HL60_Human1.10188750
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09123619
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08789309
84TFEB_21752829_ChIP-Seq_HELA_Human1.08470219
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08002528
86GATA1_19941826_ChIP-Seq_K562_Human1.07597759
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.06871088
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05952800
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03839368
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03547338
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02961559
92KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00869888
93PHF8_20622853_ChIP-Seq_HELA_Human0.98825312
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98172797
95KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97290597
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96050987
97IGF1R_20145208_ChIP-Seq_DFB_Human0.95696551
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93650435
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93129868
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92799350
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92653784
102ZNF274_21170338_ChIP-Seq_K562_Hela0.92130266
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91571153
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89900649
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88883621
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88883621
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88883621
108RBPJ_21746931_ChIP-Seq_IB4_Human0.88007414
109CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87474578
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86562879
111ETV1_20927104_ChIP-Seq_GIST48_Human0.86543712
112GATA6_21074721_ChIP-Seq_CACO-2_Human0.85161483
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84714153
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84222400
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83490600
116GATA4_25053715_ChIP-Seq_YYC3_Human0.83400177
117NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82786385
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82420792
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82180340
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82132706
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82114140
122CBX2_22325352_ChIP-Seq_293T-Rex_Human0.81630109
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81435177
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81218951
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81101421
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80444164
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79419028
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.78978239
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78061132
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75676204
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75219760
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73036217
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72513987
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71892778
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.68633907
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67968603
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67877834
138STAT1_17558387_ChIP-Seq_HELA_Human0.67621534
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65346302
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64896918
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64544489
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63779809
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.63127457
144CEBPB_22108803_ChIP-Seq_LS180_Human0.62160255
145AR_20517297_ChIP-Seq_VCAP_Human0.61421141
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61398628
147EGR1_19032775_ChIP-ChIP_M12_Human0.60917191
148BCAT_22108803_ChIP-Seq_LS180_Human0.59950056
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.58506355
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58268432
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57975145
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.55546620
153TAF15_26573619_Chip-Seq_HEK293_Human0.54482208
154RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.54195102
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54064300
156NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53881781
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53881781
158P53_21459846_ChIP-Seq_SAOS-2_Human0.52397115
159MYC_19915707_ChIP-ChIP_AK7_Human0.52348365
160PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52134259
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.51532427
162ERG_20517297_ChIP-Seq_VCAP_Human0.51388025
163CBP_21632823_ChIP-Seq_H3396_Human0.50850545
164ZNF263_19887448_ChIP-Seq_K562_Human0.50348339
165BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.50159896
166FOXA1_25552417_ChIP-Seq_VCAP_Human0.49507660
167ESR2_21235772_ChIP-Seq_MCF-7_Human0.48721154
168CDX2_22108803_ChIP-Seq_LS180_Human0.48317755
169NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.47632485
170CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47566772
171SPI1_26923725_Chip-Seq_HPCs_Mouse0.46875808
172OCT4_21477851_ChIP-Seq_ESCs_Mouse0.46599368
173FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45846686
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45123467
175NFE2_27457419_Chip-Seq_LIVER_Mouse0.45103010
176RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.44720973
177NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.44472348
178ESR1_21235772_ChIP-Seq_MCF-7_Human0.44309031
179CRX_20693478_ChIP-Seq_RETINA_Mouse0.44050540
180MYC_27129775_Chip-Seq_CORNEA_Mouse0.43708821
181PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42302334
182EZH2_27294783_Chip-Seq_NPCs_Mouse0.41977487
183LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.41171705
184GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41119790
185TAF2_19829295_ChIP-Seq_ESCs_Human0.40787262
186SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.40707650
187SUZ12_27294783_Chip-Seq_NPCs_Mouse0.40643520
188FOXH1_21741376_ChIP-Seq_EPCs_Human0.39986912
189SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39942164
190NCOR_22424771_ChIP-Seq_293T_Human0.39039372
191GATA2_19941826_ChIP-Seq_K562_Human0.38360294
192EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.38182382
193GATA1_19941827_ChIP-Seq_MEL_Mouse0.37555355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.51497856
2MP0005360_urolithiasis7.50255914
3MP0005085_abnormal_gallbladder_physiolo6.39976866
4MP0005365_abnormal_bile_salt6.25452118
5MP0008058_abnormal_DNA_repair4.88663184
6MP0008875_abnormal_xenobiotic_pharmacok4.87662152
7MP0008877_abnormal_DNA_methylation4.52215032
8MP0003806_abnormal_nucleotide_metabolis4.24558171
9MP0004147_increased_porphyrin_level4.18425338
10MP0003252_abnormal_bile_duct3.96988634
11MP0010094_abnormal_chromosome_stability3.80313445
12MP0003111_abnormal_nucleus_morphology3.66803918
13MP0010329_abnormal_lipoprotein_level3.57563678
14MP0004957_abnormal_blastocyst_morpholog3.57021647
15MP0008995_early_reproductive_senescence3.35433465
16MP0002210_abnormal_sex_determination3.32603813
17MP0008057_abnormal_DNA_replication3.29316900
18MP0003693_abnormal_embryo_hatching3.21046303
19MP0001929_abnormal_gametogenesis3.03877421
20MP0003195_calcinosis3.02884657
21MP0009840_abnormal_foam_cell3.00073984
22MP0005083_abnormal_biliary_tract2.87302524
23MP0000678_abnormal_parathyroid_gland2.70893819
24MP0005332_abnormal_amino_acid2.69216422
25MP0008007_abnormal_cellular_replicative2.51257139
26MP0003077_abnormal_cell_cycle2.49982484
27MP0001666_abnormal_nutrient_absorption2.49357187
28MP0001145_abnormal_male_reproductive2.49289283
29MP0008932_abnormal_embryonic_tissue2.45938102
30MP0003698_abnormal_male_reproductive2.35153933
31MP0003786_premature_aging2.34742040
32MP0000653_abnormal_sex_gland2.32973956
33MP0003191_abnormal_cellular_cholesterol2.24135308
34MP0000609_abnormal_liver_physiology2.14464886
35MP0002118_abnormal_lipid_homeostasis2.09756472
36MP0004019_abnormal_vitamin_homeostasis2.03723871
37MP0002138_abnormal_hepatobiliary_system1.91644802
38MP0001730_embryonic_growth_arrest1.78605790
39MP0002160_abnormal_reproductive_system1.78576437
40MP0005319_abnormal_enzyme/_coenzyme1.76320288
41MP0003868_abnormal_feces_composition1.76125733
42MP0010307_abnormal_tumor_latency1.75833298
43MP0009697_abnormal_copulation1.66518621
44MP0001764_abnormal_homeostasis1.60441904
45MP0001697_abnormal_embryo_size1.54387347
46MP0005584_abnormal_enzyme/coenzyme_acti1.50974903
47MP0001119_abnormal_female_reproductive1.48037087
48MP0002161_abnormal_fertility/fecundity1.47720515
49MP0003646_muscle_fatigue1.44533512
50MP0001672_abnormal_embryogenesis/_devel1.40209448
51MP0005380_embryogenesis_phenotype1.40209448
52MP0000350_abnormal_cell_proliferation1.39142433
53MP0003011_delayed_dark_adaptation1.38805032
54MP0002254_reproductive_system_inflammat1.38743635
55MP0005647_abnormal_sex_gland1.34192900
56MP0005451_abnormal_body_composition1.32819432
57MP0002080_prenatal_lethality1.31620289
58MP0002132_abnormal_respiratory_system1.24459355
59MP0000313_abnormal_cell_death1.23205226
60MP0003656_abnormal_erythrocyte_physiolo1.22087641
61MP0003890_abnormal_embryonic-extraembry1.20455335
62MP0009764_decreased_sensitivity_to1.19412480
63MP0000358_abnormal_cell_content/1.19183352
64MP0003984_embryonic_growth_retardation1.19016382
65MP0002084_abnormal_developmental_patter1.18404800
66MP0009643_abnormal_urine_homeostasis1.18339522
67MP0003186_abnormal_redox_activity1.17509964
68MP0002088_abnormal_embryonic_growth/wei1.15575930
69MP0000372_irregular_coat_pigmentation1.14010300
70MP0000598_abnormal_liver_morphology1.12982769
71MP0005389_reproductive_system_phenotype1.11981847
72MP0005397_hematopoietic_system_phenotyp1.09674769
73MP0001545_abnormal_hematopoietic_system1.09674769
74MP0002085_abnormal_embryonic_tissue1.09376697
75MP0003567_abnormal_fetal_cardiomyocyte1.09309119
76MP0006292_abnormal_olfactory_placode1.07452774
77MP0009763_increased_sensitivity_to1.06362473
78MP0003705_abnormal_hypodermis_morpholog1.00876638
79MP0004233_abnormal_muscle_weight0.99579589
80MP0005670_abnormal_white_adipose0.98819829
81MP0010368_abnormal_lymphatic_system0.98255012
82MP0002086_abnormal_extraembryonic_tissu0.97735946
83MP0000604_amyloidosis0.97393124
84MP0008469_abnormal_protein_level0.95798504
85MP0005636_abnormal_mineral_homeostasis0.92981461
86MP0003937_abnormal_limbs/digits/tail_de0.92592033
87MP0000647_abnormal_sebaceous_gland0.90567900
88MP0004808_abnormal_hematopoietic_stem0.88561023
89MP0009642_abnormal_blood_homeostasis0.88095892
90MP0006036_abnormal_mitochondrial_physio0.86322475
91MP0004197_abnormal_fetal_growth/weight/0.84287467
92MP0002269_muscular_atrophy0.83461146
93MP0002971_abnormal_brown_adipose0.83115596
94MP0004145_abnormal_muscle_electrophysio0.82607779
95MP0003959_abnormal_lean_body0.81865131
96MP0002249_abnormal_larynx_morphology0.81645041
97MP0006082_CNS_inflammation0.81612284
98MP0002396_abnormal_hematopoietic_system0.81582614
99MP0009765_abnormal_xenobiotic_induced0.81509962
100MP0009703_decreased_birth_body0.81373291
101MP0005376_homeostasis/metabolism_phenot0.81193706
102MP0002095_abnormal_skin_pigmentation0.78336902
103MP0003123_paternal_imprinting0.78218950
104MP0002078_abnormal_glucose_homeostasis0.76608276
105MP0003385_abnormal_body_wall0.76567464
106MP0003690_abnormal_glial_cell0.76516099
107MP0005535_abnormal_body_temperature0.74949851
108MP0004130_abnormal_muscle_cell0.72933323
109MP0005334_abnormal_fat_pad0.71914204
110MP0005410_abnormal_fertilization0.71687598
111MP0005220_abnormal_exocrine_pancreas0.70447364
112MP0005266_abnormal_metabolism0.70340332
113MP0001661_extended_life_span0.68593856
114MP0002019_abnormal_tumor_incidence0.66576115
115MP0005084_abnormal_gallbladder_morpholo0.66431488
116MP0006035_abnormal_mitochondrial_morpho0.65310957
117MP0002876_abnormal_thyroid_physiology0.65249053
118MP0005408_hypopigmentation0.64707858
119MP0001529_abnormal_vocalization0.64362541
120MP0008775_abnormal_heart_ventricle0.63655126
121MP0003724_increased_susceptibility_to0.63648637
122MP0000631_abnormal_neuroendocrine_gland0.62641490
123MP0003936_abnormal_reproductive_system0.62537436
124MP0002938_white_spotting0.61830415
125MP0005076_abnormal_cell_differentiation0.60689291
126MP0000639_abnormal_adrenal_gland0.60493792
127MP0006072_abnormal_retinal_apoptosis0.59882506
128MP0005464_abnormal_platelet_physiology0.58412523
129MP0003943_abnormal_hepatobiliary_system0.57571073
130MP0000266_abnormal_heart_morphology0.56924875
131MP0005174_abnormal_tail_pigmentation0.56814310
132MP0005395_other_phenotype0.55280315
133MP0003221_abnormal_cardiomyocyte_apopto0.54684901
134MP0003935_abnormal_craniofacial_develop0.54325445
135MP0005448_abnormal_energy_balance0.52929597
136MP0005384_cellular_phenotype0.52634693
137MP0000703_abnormal_thymus_morphology0.52155036
138MP0001756_abnormal_urination0.51515470
139MP0003718_maternal_effect0.51475933
140MP0009053_abnormal_anal_canal0.51144389
141MP0008770_decreased_survivor_rate0.49784134
142MP0005645_abnormal_hypothalamus_physiol0.49751198
143MP0004043_abnormal_pH_regulation0.48759579
144MP0005666_abnormal_adipose_tissue0.48673263
145MP0002136_abnormal_kidney_physiology0.47361870
146MP0003638_abnormal_response/metabolism_0.47128927
147MP0009672_abnormal_birth_weight0.46953800
148MP0002877_abnormal_melanocyte_morpholog0.46840482
149MP0000681_abnormal_thyroid_gland0.46579382
150MP0003329_amyloid_beta_deposits0.45923618
151MP0003436_decreased_susceptibility_to0.45218425
152MP0008874_decreased_physiological_sensi0.44240770
153MP0002060_abnormal_skin_morphology0.42229553
154MP0005166_decreased_susceptibility_to0.40645618
155MP0002928_abnormal_bile_duct0.40470026
156MP0003953_abnormal_hormone_level0.40454830
157MP0000579_abnormal_nail_morphology0.39829740
158MP0002822_catalepsy0.38740139
159MP0002168_other_aberrant_phenotype0.37945848
160MP0008873_increased_physiological_sensi0.37560104
161MP0009115_abnormal_fat_cell0.37430433
162MP0003075_altered_response_to0.36686200
163MP0002970_abnormal_white_adipose0.35341435
164MP0001853_heart_inflammation0.35224266
165MP0004782_abnormal_surfactant_physiolog0.35015699
166MP0004381_abnormal_hair_follicle0.34382876
167MP0005248_abnormal_Harderian_gland0.34328030
168MP0001243_abnormal_dermal_layer0.34234662
169MP0008872_abnormal_physiological_respon0.33061390
170MP0002796_impaired_skin_barrier0.32738577
171MP0000249_abnormal_blood_vessel0.31672083
172MP0001845_abnormal_inflammatory_respons0.31081481
173MP0000427_abnormal_hair_cycle0.29050969
174MP0009785_altered_susceptibility_to0.28344724
175MP0000230_abnormal_systemic_arterial0.28129260
176MP0004883_abnormal_blood_vessel0.27106464
177MP0005164_abnormal_response_to0.27053757
178MP0002837_dystrophic_cardiac_calcinosis0.26927825
179MP0005595_abnormal_vascular_smooth0.26761018
180MP0003699_abnormal_female_reproductive0.25714873

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.43157142
2Intrahepatic cholestasis (HP:0001406)7.33498722
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.12459724
4Prolonged partial thromboplastin time (HP:0003645)6.79215429
5Hypobetalipoproteinemia (HP:0003563)6.59636902
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51301928
7Xanthomatosis (HP:0000991)6.18000619
8Complement deficiency (HP:0004431)5.63752727
9Hyperlipoproteinemia (HP:0010980)5.44991490
10Joint hemorrhage (HP:0005261)5.01107052
11Truncus arteriosus (HP:0001660)4.90051506
12Hypolipoproteinemia (HP:0010981)4.87363234
13Chromsome breakage (HP:0040012)4.83917903
14Chromosomal breakage induced by crosslinking agents (HP:0003221)4.75493672
15Hyperammonemia (HP:0001987)4.51934522
16Abnormality of the common coagulation pathway (HP:0010990)4.47354263
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.47214567
18Epidermoid cyst (HP:0200040)4.41285025
19Hyperglycinemia (HP:0002154)4.31674045
20Fat malabsorption (HP:0002630)4.21023183
21Reticulocytosis (HP:0001923)4.20545450
22Ketosis (HP:0001946)4.17179773
23Abnormality of complement system (HP:0005339)4.17104805
24Hypoalphalipoproteinemia (HP:0003233)4.15367735
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06225000
26Abnormality of methionine metabolism (HP:0010901)4.04427757
27Abnormality of sulfur amino acid metabolism (HP:0004339)4.03982213
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94292656
29Hypercholesterolemia (HP:0003124)3.92008672
30Hypoglycemic coma (HP:0001325)3.90126321
31Hyperthyroidism (HP:0000836)3.86422283
32Abnormality of the intrinsic pathway (HP:0010989)3.83447896
33Abnormality of pyrimidine metabolism (HP:0004353)3.79499411
34Increased nuchal translucency (HP:0010880)3.76772687
35Hyperglycinuria (HP:0003108)3.76500154
36Abnormality of glycine metabolism (HP:0010895)3.74407214
37Abnormality of serine family amino acid metabolism (HP:0010894)3.74407214
38Abnormality of reticulocytes (HP:0004312)3.66905198
39Volvulus (HP:0002580)3.66239887
40Conjugated hyperbilirubinemia (HP:0002908)3.62776947
41Birth length less than 3rd percentile (HP:0003561)3.60838426
42Spontaneous abortion (HP:0005268)3.54729703
43Abnormality of cochlea (HP:0000375)3.44810728
44Bowel incontinence (HP:0002607)3.32520687
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31626185
46Abnormality of fatty-acid metabolism (HP:0004359)3.29486717
47Hyperbilirubinemia (HP:0002904)3.25252098
48Steatorrhea (HP:0002570)3.22103173
49Abnormal large intestine physiology (HP:0012700)3.18139902
50Small intestinal stenosis (HP:0012848)3.13445902
51Duodenal stenosis (HP:0100867)3.13445902
52Upper limb muscle weakness (HP:0003484)3.12991027
53Abnormality of the heme biosynthetic pathway (HP:0010472)3.11864938
54Systemic lupus erythematosus (HP:0002725)3.08519153
55Ankyloglossia (HP:0010296)3.08238419
56Myocardial infarction (HP:0001658)3.07816912
57Abnormality of serum amino acid levels (HP:0003112)3.02733867
58Delayed CNS myelination (HP:0002188)2.99955821
59Ketoacidosis (HP:0001993)2.95829992
60Abnormality of nucleobase metabolism (HP:0010932)2.95066989
61Abnormal lung lobation (HP:0002101)2.94765163
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.93333339
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93333339
64Polycythemia (HP:0001901)2.93014447
65Hepatocellular carcinoma (HP:0001402)2.86431176
66Hypochromic microcytic anemia (HP:0004840)2.83131644
67Cortical dysplasia (HP:0002539)2.77927556
68Gonadotropin excess (HP:0000837)2.77828157
69Metabolic acidosis (HP:0001942)2.74593808
70Abnormal hemoglobin (HP:0011902)2.69292764
71Aplasia/Hypoplasia of the earlobes (HP:0009906)2.68954262
72Duplicated collecting system (HP:0000081)2.68902585
73Acanthocytosis (HP:0001927)2.68207141
74Vascular calcification (HP:0004934)2.65582141
75Skin nodule (HP:0200036)2.64669782
76Glomerulonephritis (HP:0000099)2.63940250
77Abnormality of glycolysis (HP:0004366)2.63858352
78Acute myeloid leukemia (HP:0004808)2.63054604
79Progressive external ophthalmoplegia (HP:0000590)2.62206225
80Hypoparathyroidism (HP:0000829)2.61600001
81Atelectasis (HP:0100750)2.58352449
82Increased serum pyruvate (HP:0003542)2.57755978
83Dicarboxylic aciduria (HP:0003215)2.56637380
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56637380
85Lethargy (HP:0001254)2.55142352
86Reticulocytopenia (HP:0001896)2.53664666
87Myelodysplasia (HP:0002863)2.53607416
88Abnormality of purine metabolism (HP:0004352)2.52850777
89Recurrent gram-negative bacterial infections (HP:0005420)2.51449621
90Abnormality of the duodenum (HP:0002246)2.51410903
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.51246306
92Abnormality of the preputium (HP:0100587)2.50112307
93Abnormality of the renal collecting system (HP:0004742)2.49432711
94Ileus (HP:0002595)2.48792060
95Abnormality of chromosome stability (HP:0003220)2.47371412
96Morphological abnormality of the inner ear (HP:0011390)2.45177797
97Azoospermia (HP:0000027)2.44960034
98Hypoglycemic seizures (HP:0002173)2.44875769
99Cardiovascular calcification (HP:0011915)2.42829097
100Cerebral edema (HP:0002181)2.41632153
101Abnormality of DNA repair (HP:0003254)2.39153574
102Malnutrition (HP:0004395)2.37169730
103Ectopic kidney (HP:0000086)2.36684178
104Hypertensive crisis (HP:0100735)2.36667205
105Abnormal gallbladder physiology (HP:0012438)2.36236734
106Cholecystitis (HP:0001082)2.36236734
107Abnormal gallbladder morphology (HP:0012437)2.35667241
108Tubulointerstitial nephritis (HP:0001970)2.35417420
109Abnormality of homocysteine metabolism (HP:0010919)2.35389440
110Homocystinuria (HP:0002156)2.35389440
111Obsessive-compulsive behavior (HP:0000722)2.35074799
112Mitral stenosis (HP:0001718)2.32249341
113Cholelithiasis (HP:0001081)2.31753987
114Amyloidosis (HP:0011034)2.30645920
115Spastic diplegia (HP:0001264)2.30584571
116Hemorrhage of the eye (HP:0011885)2.29777572
117Abnormality of the tricuspid valve (HP:0001702)2.29538380
118Shoulder girdle muscle weakness (HP:0003547)2.29180195
119Rimmed vacuoles (HP:0003805)2.25762176
120Gingival bleeding (HP:0000225)2.25206179
121Seborrheic dermatitis (HP:0001051)2.24979291
122Neonatal onset (HP:0003623)2.23813189
123Pallor (HP:0000980)2.23303278
124Abnormality of the labia minora (HP:0012880)2.22420291
125Rhabdomyosarcoma (HP:0002859)2.21470410
126Irritability (HP:0000737)2.19995212
127Nephroblastoma (Wilms tumor) (HP:0002667)2.19171698
128Microvesicular hepatic steatosis (HP:0001414)2.18042701
129Embryonal renal neoplasm (HP:0011794)2.17054329
130Pancreatitis (HP:0001733)2.15221196
131Abnormality of iron homeostasis (HP:0011031)2.15040528
132Abnormality of the corticospinal tract (HP:0002492)2.14165045
133Thrombophlebitis (HP:0004418)2.13585054
134Renal cortical cysts (HP:0000803)2.13273287
135Brushfield spots (HP:0001088)2.12985136
136Late onset (HP:0003584)2.12730501
137Short middle phalanx of the 5th finger (HP:0004220)2.12592693
138Menorrhagia (HP:0000132)2.12159605
139Poikilocytosis (HP:0004447)2.11114236
140Redundant skin (HP:0001582)2.10879321
141Enlarged kidneys (HP:0000105)2.10519031
142Abnormality of transition element cation homeostasis (HP:0011030)2.10156309
143Premature ovarian failure (HP:0008209)2.09989396
144Upper motor neuron abnormality (HP:0002127)2.08390796
145Gout (HP:0001997)2.08207736
146Abnormality of chromosome segregation (HP:0002916)2.06467929
147Hyperinsulinemic hypoglycemia (HP:0000825)2.04648092
148Meckel diverticulum (HP:0002245)2.04615579
149Sandal gap (HP:0001852)2.04372378
150Esophageal varix (HP:0002040)2.03956940
151Vomiting (HP:0002013)2.02073825
152Nephritis (HP:0000123)2.01299599
153Generalized aminoaciduria (HP:0002909)2.00798257
154Cafe-au-lait spot (HP:0000957)2.00242366
155Abnormality of oral frenula (HP:0000190)2.00082654
15611 pairs of ribs (HP:0000878)1.98037330
157Sensorimotor neuropathy (HP:0007141)1.97671836
158Abnormality of the gallbladder (HP:0005264)1.95174285
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.93716513
160Overlapping toe (HP:0001845)1.91667134
161Metaphyseal cupping (HP:0003021)1.91605483
162Abnormality of the ileum (HP:0001549)1.90508621
163Elevated hepatic transaminases (HP:0002910)1.88955553
164Abnormal biliary tract physiology (HP:0012439)1.88123808
165Bile duct proliferation (HP:0001408)1.88123808
166Sloping forehead (HP:0000340)1.87923154
167Abnormal spermatogenesis (HP:0008669)1.87560513
168Abnormal cartilage morphology (HP:0002763)1.83910858
169Rickets (HP:0002748)1.83648241
170Nonimmune hydrops fetalis (HP:0001790)1.82537911
171Neoplasm of the colon (HP:0100273)1.81967354
172Oligodactyly (hands) (HP:0001180)1.81044119
173Opisthotonus (HP:0002179)1.80337201
174Osteomalacia (HP:0002749)1.79908132
175Attention deficit hyperactivity disorder (HP:0007018)1.79704927
176Neoplasm of the small intestine (HP:0100833)1.78466161
177Hypertriglyceridemia (HP:0002155)1.76100097
178Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75868774
179Nausea (HP:0002018)1.75008258
180Proximal tubulopathy (HP:0000114)1.74992575
181Hypophosphatemic rickets (HP:0004912)1.74802997
182Horseshoe kidney (HP:0000085)1.74305123
183Hydroxyprolinuria (HP:0003080)1.73764036
184Abnormality of the carotid arteries (HP:0005344)1.71753064
185Ependymoma (HP:0002888)1.68232327
186Secondary amenorrhea (HP:0000869)1.67939649
187Large hands (HP:0001176)1.67157116
188Scotoma (HP:0000575)1.66771515
189Neoplasm of the oral cavity (HP:0100649)1.64399856
190Choanal atresia (HP:0000453)1.63483934
191Breech presentation (HP:0001623)1.62060103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.11586515
2TTK4.55551796
3FGFR44.32774086
4SIK14.26096626
5ERN14.04544528
6PNCK3.36088061
7EIF2AK13.35257951
8KSR23.25087998
9PLK43.15510096
10TAOK33.09240757
11PDK43.05434080
12PDK33.05434080
13BUB12.89435866
14WEE12.86031870
15INSRR2.83121363
16MST1R2.80153024
17CLK12.72184274
18ERBB42.64229560
19NTRK32.50910533
20MAP3K22.48539932
21NEK12.25485251
22CDC72.22925328
23BRSK22.22387388
24RAF12.18718847
25RIPK42.10925089
26KSR12.09419915
27LATS12.07127427
28CCNB12.04033556
29PIK3CG1.97626613
30MAP2K41.93526982
31EIF2AK31.84275724
32PBK1.77567941
33MAP3K41.76007514
34PKN21.72465027
35TYK21.71885829
36BMPR21.69162416
37PDK21.64680092
38MAPK111.61880231
39TSSK61.61680873
40EEF2K1.58573600
41ZAK1.56199011
42SRPK11.55537120
43STK38L1.53283984
44FLT31.53007462
45PLK11.49750302
46NEK21.48820288
47TRIB31.47314095
48BRSK11.43629825
49BRAF1.43604684
50PINK11.40309202
51ATR1.40184331
52PTK61.35182901
53DAPK21.34527062
54MAP3K81.29378110
55CHEK21.27460930
56TGFBR21.24633524
57WNK41.24525275
58TBK11.22367460
59MST41.21132829
60CHEK11.20868945
61PLK31.18669352
62WNK11.18617926
63CDK191.17685854
64FRK1.16309435
65NEK91.14362552
66KDR1.13876734
67ABL21.11127622
68JAK21.11031130
69ATM1.08041879
70ICK1.06095522
71PASK1.04943314
72NME11.03898211
73TIE11.02258305
74PRKAA21.01550570
75JAK10.99723917
76MAPK150.98232018
77MET0.95815340
78FGFR20.94922234
79PLK20.92211382
80STK40.90223279
81CDK120.88519128
82TESK20.88499447
83TRPM70.87920605
84RPS6KB20.87887066
85DYRK1B0.87071752
86EPHB10.85717119
87CDK10.84435366
88ACVR1B0.83695015
89STK160.82968019
90CDK60.82477730
91STK30.81483184
92RET0.80040318
93PRKCZ0.79948823
94MKNK10.79165272
95ERBB20.79134463
96MAPK40.78747271
97IRAK30.78391792
98EPHA30.76960372
99SCYL20.74672154
100MAP3K70.73198209
101PRKACG0.72982729
102CDK20.72743285
103CSK0.71478910
104AURKB0.69950681
105MAP3K140.67208843
106MAP3K100.65981646
107MKNK20.65497025
108MAP3K130.65420447
109CSF1R0.64523873
110PRKAA10.62761945
111GRK10.57388921
112IKBKE0.57246972
113AURKA0.54231131
114CAMK2G0.53866186
115IRAK10.53642707
116CSNK1E0.52202830
117GSK3A0.51742907
118CAMK1D0.51533530
119YES10.51071108
120CSNK2A20.50573311
121PRKCG0.50307697
122CDK70.49964153
123ALK0.49175780
124CDK40.48239145
125SGK30.48189871
126TYRO30.47909730
127GRK60.47453752
128MAP2K60.47228772
129MARK30.46952327
130LATS20.46721058
131PAK10.46324292
132FGFR30.46151509
133SGK10.44781864
134PDK10.44233683
135MAPK120.44066812
136IGF1R0.43538314
137MTOR0.42933682
138BLK0.42384090
139MAP2K30.41442523
140MAPKAPK50.41103357
141MAP3K10.39348438
142OXSR10.38247394
143PRKDC0.38196175
144DYRK30.37969441
145PTK2B0.37827629
146CSNK2A10.37463316
147PRKCQ0.37345834
148RPS6KB10.35998370
149MAPK130.35426839
150BRD40.34683512
151PDPK10.34495726
152TNK20.33137238
153NEK60.32703341
154SGK20.32432313
155PRKCI0.32134955
156STK380.31588032
157ABL10.31453510
158CSNK1G10.30440402
159PTK20.29505046
160EGFR0.29488218
161MAP4K20.29286778
162RIPK10.29209123
163GSK3B0.28965478
164STK100.28691882
165MAPK140.27998085
166TGFBR10.26749383
167MAP2K10.26617041
168CDK11A0.25574272
169IRAK20.25370082
170MAP3K30.25221616
171PKN10.25139501
172MAPK70.24063878
173CAMK40.23488483
174MAP3K60.21249286
175PRKCA0.20813518
176NUAK10.20745485
177EIF2AK20.20070294
178BMX0.19602977
179PRKACB0.17200808
180CAMK1G0.16486964
181MAPK30.16464134

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56691905
2Mismatch repair_Homo sapiens_hsa034304.09756794
3Homologous recombination_Homo sapiens_hsa034403.92382604
4DNA replication_Homo sapiens_hsa030303.85579592
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.52865567
6Nitrogen metabolism_Homo sapiens_hsa009103.33930487
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27930708
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11279013
9RNA transport_Homo sapiens_hsa030132.97880457
10Complement and coagulation cascades_Homo sapiens_hsa046102.92319471
11Cell cycle_Homo sapiens_hsa041102.90600401
12Arginine biosynthesis_Homo sapiens_hsa002202.90285602
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73910617
14Tryptophan metabolism_Homo sapiens_hsa003802.64610536
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64463255
16Fanconi anemia pathway_Homo sapiens_hsa034602.63321752
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61267216
18Nucleotide excision repair_Homo sapiens_hsa034202.58859260
19Fatty acid degradation_Homo sapiens_hsa000712.55447840
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49643293
21Non-homologous end-joining_Homo sapiens_hsa034502.44690895
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41875018
23Basal transcription factors_Homo sapiens_hsa030222.28733923
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20944937
25Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17046848
26Base excision repair_Homo sapiens_hsa034102.12057315
27Propanoate metabolism_Homo sapiens_hsa006402.10580979
28Butanoate metabolism_Homo sapiens_hsa006502.08965292
29Peroxisome_Homo sapiens_hsa041462.08452737
30Spliceosome_Homo sapiens_hsa030402.05391248
31Chemical carcinogenesis_Homo sapiens_hsa052042.04102907
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99580541
33PPAR signaling pathway_Homo sapiens_hsa033201.96592775
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.95757528
35Staphylococcus aureus infection_Homo sapiens_hsa051501.91523643
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.90611936
37mRNA surveillance pathway_Homo sapiens_hsa030151.88901860
38Histidine metabolism_Homo sapiens_hsa003401.86808630
39Fatty acid metabolism_Homo sapiens_hsa012121.85391679
40Oocyte meiosis_Homo sapiens_hsa041141.80900066
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.78754361
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78130859
43Caffeine metabolism_Homo sapiens_hsa002321.77346728
44Retinol metabolism_Homo sapiens_hsa008301.76442161
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67522216
46beta-Alanine metabolism_Homo sapiens_hsa004101.67216106
47Selenocompound metabolism_Homo sapiens_hsa004501.65932997
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63805947
49RNA degradation_Homo sapiens_hsa030181.58351673
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51248031
51Bile secretion_Homo sapiens_hsa049761.50381906
52Pyruvate metabolism_Homo sapiens_hsa006201.49649049
53Proteasome_Homo sapiens_hsa030501.47274942
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46108570
55Phenylalanine metabolism_Homo sapiens_hsa003601.45127867
56RNA polymerase_Homo sapiens_hsa030201.43389891
57Ribosome_Homo sapiens_hsa030101.42506595
58Tyrosine metabolism_Homo sapiens_hsa003501.39762993
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39141560
60Fatty acid elongation_Homo sapiens_hsa000621.35173794
61ABC transporters_Homo sapiens_hsa020101.33168406
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.29560046
63Sulfur metabolism_Homo sapiens_hsa009201.26995945
64Folate biosynthesis_Homo sapiens_hsa007901.23718223
65Starch and sucrose metabolism_Homo sapiens_hsa005001.22785258
66Pyrimidine metabolism_Homo sapiens_hsa002401.20911248
67Fat digestion and absorption_Homo sapiens_hsa049751.18248553
68Biosynthesis of amino acids_Homo sapiens_hsa012301.15213173
69Carbon metabolism_Homo sapiens_hsa012001.12552742
70Vitamin B6 metabolism_Homo sapiens_hsa007501.09864820
71Steroid biosynthesis_Homo sapiens_hsa001001.07540286
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03549849
73Purine metabolism_Homo sapiens_hsa002301.03040689
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.99993272
75Olfactory transduction_Homo sapiens_hsa047400.97027582
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95374906
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.94351727
78Protein export_Homo sapiens_hsa030600.93812970
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93173598
80Vitamin digestion and absorption_Homo sapiens_hsa049770.90049297
81Arginine and proline metabolism_Homo sapiens_hsa003300.85815675
82mTOR signaling pathway_Homo sapiens_hsa041500.83966407
83Lysine degradation_Homo sapiens_hsa003100.83845479
84Sulfur relay system_Homo sapiens_hsa041220.83510238
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83454493
86Huntingtons disease_Homo sapiens_hsa050160.82446947
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79159272
88Parkinsons disease_Homo sapiens_hsa050120.79141511
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77617742
90Type II diabetes mellitus_Homo sapiens_hsa049300.77093527
91One carbon pool by folate_Homo sapiens_hsa006700.75686454
92Glutathione metabolism_Homo sapiens_hsa004800.71467117
93Glycerolipid metabolism_Homo sapiens_hsa005610.68391129
94p53 signaling pathway_Homo sapiens_hsa041150.65915408
95Acute myeloid leukemia_Homo sapiens_hsa052210.64009268
96N-Glycan biosynthesis_Homo sapiens_hsa005100.63862648
97Fatty acid biosynthesis_Homo sapiens_hsa000610.62660694
98Pentose phosphate pathway_Homo sapiens_hsa000300.59279371
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55303184
100Chronic myeloid leukemia_Homo sapiens_hsa052200.54051948
101ErbB signaling pathway_Homo sapiens_hsa040120.52520350
102Dorso-ventral axis formation_Homo sapiens_hsa043200.52506126
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52286286
104Oxidative phosphorylation_Homo sapiens_hsa001900.51792212
105Metabolic pathways_Homo sapiens_hsa011000.45270669
106Prion diseases_Homo sapiens_hsa050200.41502385
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38004575
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37944297
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36774638
110Viral carcinogenesis_Homo sapiens_hsa052030.36522488
111VEGF signaling pathway_Homo sapiens_hsa043700.32534091
112Linoleic acid metabolism_Homo sapiens_hsa005910.31729617
113Thyroid cancer_Homo sapiens_hsa052160.30911680
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30636955
115HIF-1 signaling pathway_Homo sapiens_hsa040660.30274309
116Phototransduction_Homo sapiens_hsa047440.29717634
117Inositol phosphate metabolism_Homo sapiens_hsa005620.28008695
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.23085248
119Pancreatic cancer_Homo sapiens_hsa052120.21565440
120Galactose metabolism_Homo sapiens_hsa000520.20915950
121Insulin resistance_Homo sapiens_hsa049310.19795753
122Epstein-Barr virus infection_Homo sapiens_hsa051690.17880027
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.17338551
124Fructose and mannose metabolism_Homo sapiens_hsa000510.17126826
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16820085
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16399897
127Glucagon signaling pathway_Homo sapiens_hsa049220.15843714
128Renal cell carcinoma_Homo sapiens_hsa052110.15459227
129Non-small cell lung cancer_Homo sapiens_hsa052230.15285859
130Prolactin signaling pathway_Homo sapiens_hsa049170.14820654
131Ovarian steroidogenesis_Homo sapiens_hsa049130.01123772
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00985108
133Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2319994
134Malaria_Homo sapiens_hsa05144-0.2306287
135Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2079083
136Regulation of autophagy_Homo sapiens_hsa04140-0.2052252
137Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1972299
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1853456
139Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1847960
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1842274
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1777081
142Hepatitis C_Homo sapiens_hsa05160-0.1768748
143Amoebiasis_Homo sapiens_hsa05146-0.1673730
144Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1638380
145Legionellosis_Homo sapiens_hsa05134-0.1526500
146Pertussis_Homo sapiens_hsa05133-0.1475507
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1461706
148African trypanosomiasis_Homo sapiens_hsa05143-0.1359819
149Insulin signaling pathway_Homo sapiens_hsa04910-0.1086822
150Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1012236
151Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0880388
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0256800
153AMPK signaling pathway_Homo sapiens_hsa04152-0.0017714

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