MEIS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.72303627
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55989434
3regulation of synapse structural plasticity (GO:0051823)4.40366672
4presynaptic membrane organization (GO:0097090)4.16462574
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13600518
6layer formation in cerebral cortex (GO:0021819)4.07545370
7pyrimidine nucleobase catabolic process (GO:0006208)4.06358629
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.01398977
9vocalization behavior (GO:0071625)3.92238355
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.91202207
11negative regulation of cytosolic calcium ion concentration (GO:0051481)3.88936109
12synaptic vesicle maturation (GO:0016188)3.86706568
13locomotory exploration behavior (GO:0035641)3.85386846
14prepulse inhibition (GO:0060134)3.80094132
15protein localization to synapse (GO:0035418)3.73460170
16synaptic vesicle docking involved in exocytosis (GO:0016081)3.63597344
17synaptic vesicle exocytosis (GO:0016079)3.62361152
18dendritic spine morphogenesis (GO:0060997)3.61175091
19nucleobase catabolic process (GO:0046113)3.60938173
20regulation of glutamate receptor signaling pathway (GO:1900449)3.59194963
21striatum development (GO:0021756)3.47815171
22neuron cell-cell adhesion (GO:0007158)3.45781818
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39979328
24regulation of synaptic vesicle exocytosis (GO:2000300)3.39353341
25adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.39266383
26auditory behavior (GO:0031223)3.36299012
27regulation of dendritic spine morphogenesis (GO:0061001)3.36006417
28neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.35919958
29neuron recognition (GO:0008038)3.33829434
30cell migration in hindbrain (GO:0021535)3.33185280
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29754749
32exploration behavior (GO:0035640)3.29188149
33axonal fasciculation (GO:0007413)3.27499782
34dopamine receptor signaling pathway (GO:0007212)3.26394868
35substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.25736082
36substrate-independent telencephalic tangential migration (GO:0021826)3.25736082
37regulation of neuronal synaptic plasticity (GO:0048168)3.22838906
38innervation (GO:0060384)3.22811290
39central nervous system neuron axonogenesis (GO:0021955)3.22742047
40retinal ganglion cell axon guidance (GO:0031290)3.17568917
41dendrite morphogenesis (GO:0048813)3.16871027
42limb bud formation (GO:0060174)3.16257317
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15090683
44synaptic transmission, dopaminergic (GO:0001963)3.11431512
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10998570
46regulation of synaptic vesicle transport (GO:1902803)3.06436721
47regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.02639922
48regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.02639922
49response to pheromone (GO:0019236)3.01938407
50positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00742570
51neuron fate determination (GO:0048664)2.97838506
52neurotransmitter-gated ion channel clustering (GO:0072578)2.97147249
53central nervous system projection neuron axonogenesis (GO:0021952)2.96005411
54dendritic spine organization (GO:0097061)2.92014112
55synaptic transmission, glutamatergic (GO:0035249)2.90247607
56neurotransmitter secretion (GO:0007269)2.89850797
57ionotropic glutamate receptor signaling pathway (GO:0035235)2.88682561
58neuron-neuron synaptic transmission (GO:0007270)2.87125692
59response to auditory stimulus (GO:0010996)2.86257562
60behavioral defense response (GO:0002209)2.84923375
61behavioral fear response (GO:0001662)2.84923375
62positive regulation of synapse maturation (GO:0090129)2.82977914
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82620920
64startle response (GO:0001964)2.81082688
65synaptic vesicle endocytosis (GO:0048488)2.79379248
66neuronal ion channel clustering (GO:0045161)2.78452612
67glutamate receptor signaling pathway (GO:0007215)2.78349709
68glutamate secretion (GO:0014047)2.78343989
69postsynaptic membrane organization (GO:0001941)2.77641809
70behavioral response to nicotine (GO:0035095)2.76229121
71nonmotile primary cilium assembly (GO:0035058)2.73969828
72limb development (GO:0060173)2.73283254
73appendage development (GO:0048736)2.73283254
74positive regulation of dendritic spine morphogenesis (GO:0061003)2.72401632
75olfactory bulb development (GO:0021772)2.71951603
76behavioral response to cocaine (GO:0048148)2.70177878
77regulation of synaptic transmission, glutamatergic (GO:0051966)2.70088021
78negative regulation of hormone biosynthetic process (GO:0032353)2.70086227
79neuromuscular process controlling balance (GO:0050885)2.69870285
80positive regulation of membrane potential (GO:0045838)2.66319877
81regulation of neurotransmitter uptake (GO:0051580)2.65889215
82mechanosensory behavior (GO:0007638)2.65242368
83cerebral cortex radially oriented cell migration (GO:0021799)2.64070484
84positive regulation of neurotransmitter transport (GO:0051590)2.63325402
85cAMP catabolic process (GO:0006198)2.63266885
86spinal cord development (GO:0021510)2.62482722
87regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62378859
88ganglion development (GO:0061548)2.61825852
89cranial nerve morphogenesis (GO:0021602)2.60889981
90sympathetic nervous system development (GO:0048485)2.59925483
91membrane hyperpolarization (GO:0060081)2.59771288
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59569496
93fear response (GO:0042596)2.58651092
94synapse assembly (GO:0007416)2.58293982
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.57922111
96response to amphetamine (GO:0001975)2.57865593
97long-term memory (GO:0007616)2.57036366
98transmission of nerve impulse (GO:0019226)2.56609813
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56133223
100behavioral response to ethanol (GO:0048149)2.55743683
101intraciliary transport (GO:0042073)2.55397690
102cell communication by electrical coupling (GO:0010644)2.55368112
103negative chemotaxis (GO:0050919)2.55284574
104apical protein localization (GO:0045176)2.55154551
105regulation of respiratory system process (GO:0044065)2.54950459
106artery development (GO:0060840)2.54624158
107glycine transport (GO:0015816)2.53982179
108calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51819067
109positive regulation of neurotransmitter secretion (GO:0001956)2.51673647
110negative regulation of astrocyte differentiation (GO:0048712)2.51597644
111regulation of synaptic plasticity (GO:0048167)2.51172493
112long-term synaptic potentiation (GO:0060291)2.50837229
113positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49955051
114regulation of action potential (GO:0098900)2.49316882
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49116347
116regulation of axon guidance (GO:1902667)2.48267961
117regulation of postsynaptic membrane potential (GO:0060078)2.47896312
118ephrin receptor signaling pathway (GO:0048013)2.47114944
119regulation of axon extension involved in axon guidance (GO:0048841)2.47068749
120regulation of synaptic transmission, GABAergic (GO:0032228)2.46071197
121righting reflex (GO:0060013)2.45879803
122regulation of vesicle fusion (GO:0031338)2.45767737
123type B pancreatic cell development (GO:0003323)2.44685640
124establishment of nucleus localization (GO:0040023)2.44429854
125regulation of dendritic spine development (GO:0060998)2.44405276
126negative regulation of dendrite development (GO:2000171)2.44321449
127cochlea development (GO:0090102)2.43781280
128kidney morphogenesis (GO:0060993)2.41704320
129regulation of membrane repolarization (GO:0060306)2.40518742
130activation of protein kinase A activity (GO:0034199)2.40093961
131glial cell proliferation (GO:0014009)2.39614724
132cyclic nucleotide catabolic process (GO:0009214)2.39548210
133spinal cord motor neuron differentiation (GO:0021522)2.37839313
134regulation of timing of cell differentiation (GO:0048505)2.37789693
135cardiac chamber formation (GO:0003207)2.37052243
136urinary tract smooth muscle contraction (GO:0014848)2.33840343
137dorsal/ventral axis specification (GO:0009950)2.33564514
138epithelial cilium movement (GO:0003351)2.32948709
139insulin secretion (GO:0030073)2.31241638
140hindbrain development (GO:0030902)2.30523234
141dentate gyrus development (GO:0021542)2.29954020
142regulation of feeding behavior (GO:0060259)2.29524329
143cerebral cortex cell migration (GO:0021795)2.28971532
144calcium ion import (GO:0070509)2.28240589
145epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27772261
146endocrine pancreas development (GO:0031018)2.26557070
147protein localization to cilium (GO:0061512)2.26289529
148cilium assembly (GO:0042384)2.24314126
149cornea development in camera-type eye (GO:0061303)2.24032480
150brain morphogenesis (GO:0048854)2.23594390
151positive regulation of synapse assembly (GO:0051965)2.21604850
152cardiac ventricle formation (GO:0003211)2.20977074
153cilium organization (GO:0044782)2.20755567
154negative regulation of axon guidance (GO:1902668)2.18892497
155protein polyglutamylation (GO:0018095)2.18048151
156cerebral cortex development (GO:0021987)2.15657398
157negative regulation of hormone metabolic process (GO:0032351)2.15080297
158regulation of development, heterochronic (GO:0040034)2.13223509
159homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.12214834
160regulation of type B pancreatic cell apoptotic process (GO:2000674)2.12149745
161detection of calcium ion (GO:0005513)2.11573799
162embryonic retina morphogenesis in camera-type eye (GO:0060059)2.10598124
163dermatan sulfate biosynthetic process (GO:0030208)2.10419985
164negative regulation of axon extension involved in axon guidance (GO:0048843)2.10365930
165regulation of synapse assembly (GO:0051963)2.09002298
166cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.08708451
167chemosensory behavior (GO:0007635)2.08266137
168cellular component assembly involved in morphogenesis (GO:0010927)2.08174643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44026317
2GBX2_23144817_ChIP-Seq_PC3_Human3.15907900
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75878524
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71392726
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.70849902
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68483130
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63177354
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59204491
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59204491
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51989784
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.30294345
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27571472
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.26830784
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26478202
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24884789
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.20149134
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18804813
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18351522
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.16509736
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14236618
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09079979
22REST_21632747_ChIP-Seq_MESCs_Mouse2.07362934
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03468275
24DROSHA_22980978_ChIP-Seq_HELA_Human1.97761934
25AR_21572438_ChIP-Seq_LNCaP_Human1.85887700
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84622988
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82256940
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74336754
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73017662
30* CBX2_27304074_Chip-Seq_ESCs_Mouse1.72678828
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70980615
32VDR_22108803_ChIP-Seq_LS180_Human1.69628038
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69452390
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65976329
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60806090
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59995627
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57696645
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.56680727
39RNF2_27304074_Chip-Seq_NSC_Mouse1.55468671
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.53441051
41EWS_26573619_Chip-Seq_HEK293_Human1.51325091
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43838274
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.41439217
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40462089
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40379045
46* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39863800
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.39464560
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38607528
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.38437676
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37610770
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37039066
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35219622
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.34882066
54BCAT_22108803_ChIP-Seq_LS180_Human1.33034796
55YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32876710
56* STAT3_23295773_ChIP-Seq_U87_Human1.32645054
57* P300_19829295_ChIP-Seq_ESCs_Human1.32316683
58FUS_26573619_Chip-Seq_HEK293_Human1.32258433
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30497633
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.30132804
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29869240
62* AR_19668381_ChIP-Seq_PC3_Human1.29161842
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28285950
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28205297
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27800496
66* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27341755
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26777155
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25414504
69IGF1R_20145208_ChIP-Seq_DFB_Human1.25214183
70CBP_20019798_ChIP-Seq_JUKART_Human1.25134615
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25134615
72* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24310382
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23249223
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22326713
75* NANOG_18555785_Chip-Seq_ESCs_Mouse1.21162664
76* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20447039
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20417800
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19961396
79ER_23166858_ChIP-Seq_MCF-7_Human1.19587854
80* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19554093
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19281634
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.18963278
83SOX9_26525672_Chip-Seq_HEART_Mouse1.18803653
84AR_25329375_ChIP-Seq_VCAP_Human1.17599630
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17314808
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16673610
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16170625
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15775833
89TP53_18474530_ChIP-ChIP_U2OS_Human1.13907677
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13886584
91* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12853654
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.12678748
93* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12615111
94AHR_22903824_ChIP-Seq_MCF-7_Human1.12216629
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11454118
96ZNF274_21170338_ChIP-Seq_K562_Hela1.10865329
97* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10735301
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10190731
99TAF15_26573619_Chip-Seq_HEK293_Human1.09818120
100* TCF4_23295773_ChIP-Seq_U87_Human1.09372094
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09320246
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09315963
103* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08521958
104* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08203030
105* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08203030
106* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06838388
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.06378381
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05963320
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05890663
110* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05701000
111* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05388994
112KDM2B_26808549_Chip-Seq_REH_Human1.05129666
113* TCF4_22108803_ChIP-Seq_LS180_Human1.05120101
114* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04015319
115* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03820272
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.03773875
117* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03165151
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.02541131
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02116451
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.99324922
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96646991
122* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96329333
123* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95391980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.22435238
2MP0002822_catalepsy3.71425076
3MP0003635_abnormal_synaptic_transmissio2.81325601
4MP0003880_abnormal_central_pattern2.72851857
5MP0004270_analgesia2.72843279
6MP0002063_abnormal_learning/memory/cond2.48547301
7MP0003787_abnormal_imprinting2.21123563
8MP0003122_maternal_imprinting2.16866550
9MP0006292_abnormal_olfactory_placode2.16419310
10MP0009745_abnormal_behavioral_response2.09269133
11MP0002837_dystrophic_cardiac_calcinosis2.06979243
12MP0000778_abnormal_nervous_system2.04758698
13MP0005423_abnormal_somatic_nervous2.01697994
14MP0001486_abnormal_startle_reflex1.97673497
15MP0005646_abnormal_pituitary_gland1.96815035
16MP0002572_abnormal_emotion/affect_behav1.92623477
17MP0005248_abnormal_Harderian_gland1.90238407
18MP0010030_abnormal_orbit_morphology1.90062384
19MP0002734_abnormal_mechanical_nocicepti1.80713924
20MP0001529_abnormal_vocalization1.79573637
21MP0003121_genomic_imprinting1.77265326
22MP0002909_abnormal_adrenal_gland1.76573277
23MP0002184_abnormal_innervation1.76462717
24MP0002735_abnormal_chemical_nociception1.65821224
25MP0000631_abnormal_neuroendocrine_gland1.64305612
26MP0002064_seizures1.61039441
27MP0009780_abnormal_chondrocyte_physiolo1.60583042
28MP0003385_abnormal_body_wall1.59552847
29MP0001984_abnormal_olfaction1.59420551
30MP0002557_abnormal_social/conspecific_i1.58276580
31MP0005499_abnormal_olfactory_system1.57708465
32MP0005394_taste/olfaction_phenotype1.57708465
33MP0002653_abnormal_ependyma_morphology1.56513119
34MP0000534_abnormal_ureter_morphology1.54838368
35MP0000678_abnormal_parathyroid_gland1.51184505
36MP0000955_abnormal_spinal_cord1.48911898
37MP0009046_muscle_twitch1.45865968
38MP0001968_abnormal_touch/_nociception1.42205925
39MP0008789_abnormal_olfactory_epithelium1.42132122
40MP0003942_abnormal_urinary_system1.40245492
41MP0006072_abnormal_retinal_apoptosis1.40151605
42MP0004811_abnormal_neuron_physiology1.38447835
43MP0002272_abnormal_nervous_system1.38070910
44MP0003195_calcinosis1.37246974
45MP0005386_behavior/neurological_phenoty1.35268029
46MP0004924_abnormal_behavior1.35268029
47MP0001188_hyperpigmentation1.33481961
48MP0003123_paternal_imprinting1.32644481
49MP0002249_abnormal_larynx_morphology1.30252688
50MP0000049_abnormal_middle_ear1.29211024
51MP0001502_abnormal_circadian_rhythm1.28925463
52MP0000569_abnormal_digit_pigmentation1.28232917
53MP0003283_abnormal_digestive_organ1.27696844
54MP0002882_abnormal_neuron_morphology1.25208863
55MP0000462_abnormal_digestive_system1.23699443
56MP0002733_abnormal_thermal_nociception1.21568449
57MP0003755_abnormal_palate_morphology1.20303001
58MP0004885_abnormal_endolymph1.19961463
59MP0005551_abnormal_eye_electrophysiolog1.19066185
60MP0004133_heterotaxia1.15628747
61MP0004233_abnormal_muscle_weight1.15272918
62MP0001970_abnormal_pain_threshold1.15073081
63MP0002152_abnormal_brain_morphology1.14757976
64MP0002234_abnormal_pharynx_morphology1.14072719
65MP0001346_abnormal_lacrimal_gland1.12977347
66MP0005187_abnormal_penis_morphology1.12075351
67MP0000013_abnormal_adipose_tissue1.12030970
68MP0003119_abnormal_digestive_system1.11496652
69MP0001177_atelectasis1.10338898
70MP0005253_abnormal_eye_physiology1.09162438
71MP0005645_abnormal_hypothalamus_physiol1.08786856
72MP0003861_abnormal_nervous_system1.08351229
73MP0003935_abnormal_craniofacial_develop1.07737709
74MP0002067_abnormal_sensory_capabilities1.07603142
75MP0005409_darkened_coat_color1.05897605
76MP0009250_abnormal_appendicular_skeleto1.04790216
77MP0002928_abnormal_bile_duct1.03618776
78MP0001944_abnormal_pancreas_morphology1.02595112
79MP0004215_abnormal_myocardial_fiber1.01640884
80MP0002638_abnormal_pupillary_reflex1.01608947
81MP0010386_abnormal_urinary_bladder1.00987885
82MP0004085_abnormal_heartbeat1.00531420
83MP0010368_abnormal_lymphatic_system0.96493568
84MP0000427_abnormal_hair_cycle0.95051677
85MP0004142_abnormal_muscle_tone0.94406724
86MP0002116_abnormal_craniofacial_bone0.94273456
87MP0004043_abnormal_pH_regulation0.93996241
88MP0008775_abnormal_heart_ventricle0.93399454
89MP0009053_abnormal_anal_canal0.92495528
90MP0004858_abnormal_nervous_system0.92235740
91MP0005367_renal/urinary_system_phenotyp0.92072907
92MP0000516_abnormal_urinary_system0.92072907
93MP0001501_abnormal_sleep_pattern0.91974249
94MP0002066_abnormal_motor_capabilities/c0.91627352
95MP0008877_abnormal_DNA_methylation0.91188665
96MP0003890_abnormal_embryonic-extraembry0.90212971
97MP0002177_abnormal_outer_ear0.90054156
98MP0002233_abnormal_nose_morphology0.89936105
99MP0002938_white_spotting0.89791243
100MP0002752_abnormal_somatic_nervous0.88891365
101MP0004145_abnormal_muscle_electrophysio0.88338001
102MP0000428_abnormal_craniofacial_morphol0.88232400
103MP0000537_abnormal_urethra_morphology0.87872891
104MP0003938_abnormal_ear_development0.87736292
105MP0000639_abnormal_adrenal_gland0.87638994
106MP0002736_abnormal_nociception_after0.86677760
107MP0001299_abnormal_eye_distance/0.86240400
108MP0003137_abnormal_impulse_conducting0.85609662
109MP0002932_abnormal_joint_morphology0.85527352
110MP0002751_abnormal_autonomic_nervous0.85179403
111MP0006276_abnormal_autonomic_nervous0.85045656
112MP0003115_abnormal_respiratory_system0.84799817
113MP0008569_lethality_at_weaning0.84453960
114MP0003937_abnormal_limbs/digits/tail_de0.84337243
115MP0000026_abnormal_inner_ear0.84250327
116MP0001440_abnormal_grooming_behavior0.82691298
117MP0002069_abnormal_eating/drinking_beha0.82106424
118MP0000566_synostosis0.81993207
119MP0002102_abnormal_ear_morphology0.80518916
120MP0002081_perinatal_lethality0.79781945

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.29201840
2Focal motor seizures (HP:0011153)3.46584752
3Hyperventilation (HP:0002883)3.35783679
4Hepatoblastoma (HP:0002884)3.32463434
5Focal seizures (HP:0007359)2.90703765
6Epileptic encephalopathy (HP:0200134)2.87081457
7Nephronophthisis (HP:0000090)2.75595025
8Pancreatic fibrosis (HP:0100732)2.72596561
9Papillary thyroid carcinoma (HP:0002895)2.71396779
10Medial flaring of the eyebrow (HP:0010747)2.69875970
11Febrile seizures (HP:0002373)2.65347018
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62476459
13Short 4th metacarpal (HP:0010044)2.62476459
14Hyperinsulinemic hypoglycemia (HP:0000825)2.55803962
15Midline defect of the nose (HP:0004122)2.53212505
16True hermaphroditism (HP:0010459)2.52359774
17Abnormality of the renal medulla (HP:0100957)2.43006959
18Pancreatic cysts (HP:0001737)2.42891849
19Genetic anticipation (HP:0003743)2.40783812
20Cutaneous finger syndactyly (HP:0010554)2.39200136
21Molar tooth sign on MRI (HP:0002419)2.39181694
22Abnormality of midbrain morphology (HP:0002418)2.39181694
23Megalencephaly (HP:0001355)2.33054495
24Hypothermia (HP:0002045)2.32996478
25Torticollis (HP:0000473)2.32080340
26Congenital primary aphakia (HP:0007707)2.30885008
27Prominent metopic ridge (HP:0005487)2.28959620
28Vitreoretinal degeneration (HP:0000655)2.28222105
29Intestinal atresia (HP:0011100)2.27908588
30Enlarged penis (HP:0000040)2.24839723
31Progressive cerebellar ataxia (HP:0002073)2.22896020
32Ankle clonus (HP:0011448)2.15198032
33EEG with generalized epileptiform discharges (HP:0011198)2.14644728
34Aqueductal stenosis (HP:0002410)2.14236370
35Nephrogenic diabetes insipidus (HP:0009806)2.13578266
36Ankyloglossia (HP:0010296)2.13306980
37Pachygyria (HP:0001302)2.13116441
38Protruding tongue (HP:0010808)2.12923104
39Action tremor (HP:0002345)2.11442807
40Epileptiform EEG discharges (HP:0011182)2.10177496
41Renal duplication (HP:0000075)2.09205833
42Neoplasm of the heart (HP:0100544)2.08920486
43Abnormality of the renal cortex (HP:0011035)2.08827658
44Hypsarrhythmia (HP:0002521)2.08491832
45Annular pancreas (HP:0001734)2.08177310
46Hypoglycemic coma (HP:0001325)2.07961785
47Excessive salivation (HP:0003781)2.07451814
48Drooling (HP:0002307)2.07451814
49Hyperglycemia (HP:0003074)2.06426780
50Visual hallucinations (HP:0002367)2.06130528
51Central scotoma (HP:0000603)2.04955362
52Broad-based gait (HP:0002136)2.04693336
53Abnormality of the ischium (HP:0003174)2.03736955
54Cutaneous syndactyly (HP:0012725)2.02681181
55Hypoglycemic seizures (HP:0002173)2.02482563
56Prolonged QT interval (HP:0001657)2.01960051
57Morphological abnormality of the middle ear (HP:0008609)2.01801829
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01196576
59Hypoplastic ischia (HP:0003175)1.99605380
60Congenital stationary night blindness (HP:0007642)1.99582567
61Lissencephaly (HP:0001339)1.98884321
62Focal dystonia (HP:0004373)1.98048404
63Postaxial hand polydactyly (HP:0001162)1.97769602
64Absent eyebrow (HP:0002223)1.97145549
65Abnormality of the aortic arch (HP:0012303)1.96330923
66Downturned corners of mouth (HP:0002714)1.95499808
67Bicornuate uterus (HP:0000813)1.94241057
68Limb dystonia (HP:0002451)1.93684028
69Poor eye contact (HP:0000817)1.93349821
70Abnormal pancreas size (HP:0012094)1.92888198
71Cystic liver disease (HP:0006706)1.92741556
72Abnormality of the 4th metacarpal (HP:0010012)1.92102161
73Renal hypoplasia (HP:0000089)1.90212891
74Depression (HP:0000716)1.89853837
75Exotropia (HP:0000577)1.89674764
76Urinary bladder sphincter dysfunction (HP:0002839)1.88639190
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88257016
78Anxiety (HP:0000739)1.86008847
79Shawl scrotum (HP:0000049)1.85600599
80Ketoacidosis (HP:0001993)1.84673980
81Obsessive-compulsive behavior (HP:0000722)1.83058793
82* Pointed chin (HP:0000307)1.81760474
83Poor coordination (HP:0002370)1.81753161
84Impaired vibration sensation in the lower limbs (HP:0002166)1.81607344
85Stereotypic behavior (HP:0000733)1.81038656
86Macroorchidism (HP:0000053)1.80798443
87Volvulus (HP:0002580)1.80245235
88Absence seizures (HP:0002121)1.79774062
89Abnormality of macular pigmentation (HP:0008002)1.79069129
90Craniofacial dystonia (HP:0012179)1.78927253
91Chorioretinal atrophy (HP:0000533)1.77832644
92Chronic hepatic failure (HP:0100626)1.77427832
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.76866129
94Aplasia/Hypoplasia of the lens (HP:0008063)1.76780133
95Pheochromocytoma (HP:0002666)1.76430672
96Optic nerve hypoplasia (HP:0000609)1.76364869
97Gait imbalance (HP:0002141)1.76239883
98Postaxial foot polydactyly (HP:0001830)1.74792449
99Hypoplasia of the fovea (HP:0007750)1.74689861
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.74689861
101Shallow orbits (HP:0000586)1.73318852
102Atonic seizures (HP:0010819)1.73018462
103Agitation (HP:0000713)1.72036523
104Generalized tonic-clonic seizures (HP:0002069)1.71812621
105* Narrow forehead (HP:0000341)1.71147488
106Short foot (HP:0001773)1.70520898
107Amblyopia (HP:0000646)1.67311030
108Abnormality of the labia minora (HP:0012880)1.66163439
109Aplasia involving bones of the upper limbs (HP:0009823)1.65706150
110Aplasia of the phalanges of the hand (HP:0009802)1.65706150
111Aplasia involving bones of the extremities (HP:0009825)1.65706150
112Abnormality of the fovea (HP:0000493)1.65489247
113Impaired social interactions (HP:0000735)1.64803097
114Abnormal social behavior (HP:0012433)1.64803097
115Preaxial foot polydactyly (HP:0001841)1.63567336
116Limited hip movement (HP:0008800)1.63128722
117Renal cortical cysts (HP:0000803)1.62959856
118Large for gestational age (HP:0001520)1.62008970
119Genital tract atresia (HP:0001827)1.61366375
120Neoplasm of the adrenal cortex (HP:0100641)1.61251906
121Hemiparesis (HP:0001269)1.59741759
122Abnormality of the antihelix (HP:0009738)1.59112368
123Abnormality of endocrine pancreas physiology (HP:0012093)1.59103318
124Abnormality of the pancreatic islet cells (HP:0006476)1.59103318
125Vaginal atresia (HP:0000148)1.57420870
126Dysdiadochokinesis (HP:0002075)1.57368111
127Renal dysplasia (HP:0000110)1.56231183
128Widely spaced teeth (HP:0000687)1.56108943
129Bifid tongue (HP:0010297)1.55747623
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.55532787
131* Prominent nasal bridge (HP:0000426)1.55436486
132Tubulointerstitial nephritis (HP:0001970)1.54088021
133Micropenis (HP:0000054)1.53933566
134Type II lissencephaly (HP:0007260)1.53859554
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.53813044
136Abnormality of the labia majora (HP:0012881)1.53692281
137Papilledema (HP:0001085)1.53306976
138Arterial tortuosity (HP:0005116)1.52802309
139Abnormality of the metopic suture (HP:0005556)1.52485477
140Tented upper lip vermilion (HP:0010804)1.51971858
141Tubular atrophy (HP:0000092)1.51874270
142Hypoplastic labia majora (HP:0000059)1.51492241
143Gaze-evoked nystagmus (HP:0000640)1.51041772
144Blue irides (HP:0000635)1.49649854
145Atelectasis (HP:0100750)1.49562258
146Absent speech (HP:0001344)1.49436146
147Microglossia (HP:0000171)1.49104644
148Trigonocephaly (HP:0000243)1.48610094
149Septo-optic dysplasia (HP:0100842)1.48519625
150Obstructive sleep apnea (HP:0002870)1.47362714
151Dialeptic seizures (HP:0011146)1.47222629
152Abnormal EKG (HP:0003115)1.47144062
153Fetal akinesia sequence (HP:0001989)1.47030089
154Anophthalmia (HP:0000528)1.46980491
155Thyroid carcinoma (HP:0002890)1.46530478
156Overgrowth (HP:0001548)1.46294917
157Truncus arteriosus (HP:0001660)1.45235097
158Intellectual disability, moderate (HP:0002342)1.44594038
159Scotoma (HP:0000575)1.44398902
160Sacral dimple (HP:0000960)1.43739410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.18107821
2MARK13.60201446
3NTRK33.29480794
4PRKD33.18868729
5MAP3K92.57928200
6MAP3K42.53678041
7MAP4K22.20925787
8LATS12.15471543
9KSR22.09203909
10KSR12.07872571
11PAK62.01359147
12MAPK131.94591115
13NTRK21.89999008
14LATS21.84699957
15MINK11.78866267
16MAP2K71.75236088
17DAPK21.71221447
18SIK21.63620125
19PNCK1.62192189
20BMPR1B1.59315361
21MAP3K61.44904114
22WNK31.43196247
23TAOK11.34848637
24PKN21.34308646
25ERBB31.34112643
26CAMKK11.30305462
27INSRR1.26760057
28PRPF4B1.26707107
29MKNK21.23919534
30CDK51.20691152
31STK391.20379439
32SGK21.20283631
33DMPK1.16724077
34TYRO31.14710706
35SGK4941.13767042
36SGK2231.13767042
37MAP3K21.12774849
38EPHB21.09112169
39STK381.08111337
40CSNK1G11.07948586
41NTRK11.07893382
42CASK1.07497504
43TRIM281.05820647
44WNK41.03712945
45UHMK11.03403052
46DYRK21.00751461
47MAP2K40.99385532
48OBSCN0.98425737
49MARK20.92240399
50SGK30.88996221
51AKT30.88116567
52DYRK1A0.88097824
53PDGFRA0.87740070
54FLT30.86796944
55CDK80.86448033
56RAF10.84763361
57PLK20.84179411
58ADRBK20.83653408
59SIK30.81915355
60TNIK0.81432967
61CDC42BPA0.81005611
62PAK30.80807808
63RET0.79515912
64BRD40.78496616
65CSNK1G30.78132370
66BMPR20.77392048
67MAPK150.76209476
68PRKCH0.75850348
69EPHA30.74296980
70PRKD20.74095036
71PHKG20.73693697
72PHKG10.73693697
73BRAF0.72759289
74STK38L0.72583919
75CSNK1G20.70965615
76BCR0.70917297
77BRSK20.70087248
78PASK0.69480699
79CDK180.69319314
80DDR20.69048875
81GRK10.68601068
82NLK0.68405749
83CAMK2A0.66276802
84CDK150.65204476
85PRKCG0.64047385
86FGFR30.63847556
87CDK140.63750064
88SGK10.63627637
89CAMK10.62693054
90CSNK1A1L0.61247249
91CAMK1D0.61162654
92FRK0.60455214
93WNK10.58240250
94RIPK10.57983101
95STK30.57360368
96PRKAA10.57208004
97FER0.56617189
98ARAF0.56030326
99PKN10.55545321
100HIPK20.55178943
101RPS6KA20.54221364
102CAMK1G0.54105308
103MAPK100.53695700
104CDK11A0.53598155
105CAMKK20.53511162
106FGFR10.52854240
107OXSR10.52768888
108ADRBK10.52733162
109NUAK10.51897984
110PRKCZ0.51675351
111MAP3K130.51371589
112DAPK10.51057765
113ROCK10.49592296
114RPS6KA30.48398116
115CDK30.48113820
116PRKCE0.48099785
117ACVR1B0.48053112
118CAMK40.45717793
119PRKG10.45275151
120STK110.44990464
121PIK3CA0.44890796
122WEE10.44189311
123NEK60.43560265
124ERBB20.42805892
125MKNK10.42652839
126MAP2K10.42478725
127FGFR20.42314154
128ERBB40.42196028
129PTK2B0.41884843
130LMTK20.41335845
131GSK3B0.40880007
132PTK20.40809908
133CSNK1E0.40392910
134TAOK20.39893503
135PINK10.39675566
136CAMK2D0.39244685
137LIMK10.38817109
138CAMK2B0.38562627
139MAP3K70.37679441
140PRKACA0.35063821

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.62983278
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58449396
3Olfactory transduction_Homo sapiens_hsa047402.52663759
4Circadian entrainment_Homo sapiens_hsa047132.39506718
5GABAergic synapse_Homo sapiens_hsa047272.36288378
6Morphine addiction_Homo sapiens_hsa050322.31976711
7Butanoate metabolism_Homo sapiens_hsa006502.28900602
8Cocaine addiction_Homo sapiens_hsa050302.23200981
9Amphetamine addiction_Homo sapiens_hsa050312.21080899
10Synaptic vesicle cycle_Homo sapiens_hsa047212.15374864
11Dopaminergic synapse_Homo sapiens_hsa047282.14358329
12Insulin secretion_Homo sapiens_hsa049112.14336892
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12723701
14Glutamatergic synapse_Homo sapiens_hsa047242.09155551
15Long-term potentiation_Homo sapiens_hsa047202.04317984
16Cholinergic synapse_Homo sapiens_hsa047251.99557744
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84125935
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80294476
19Renin secretion_Homo sapiens_hsa049241.74547104
20Axon guidance_Homo sapiens_hsa043601.63414976
21Serotonergic synapse_Homo sapiens_hsa047261.61221327
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60050912
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58892038
24Gap junction_Homo sapiens_hsa045401.55586204
25Long-term depression_Homo sapiens_hsa047301.46978957
26GnRH signaling pathway_Homo sapiens_hsa049121.46589610
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45922774
28Salivary secretion_Homo sapiens_hsa049701.45833794
29Protein export_Homo sapiens_hsa030601.43706481
30Type II diabetes mellitus_Homo sapiens_hsa049301.38149425
31Circadian rhythm_Homo sapiens_hsa047101.36138526
32cAMP signaling pathway_Homo sapiens_hsa040241.35941571
33Taste transduction_Homo sapiens_hsa047421.35450889
34Gastric acid secretion_Homo sapiens_hsa049711.30047069
35Glioma_Homo sapiens_hsa052141.26884713
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26135673
37Calcium signaling pathway_Homo sapiens_hsa040201.23051321
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22804540
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21508620
40Melanogenesis_Homo sapiens_hsa049161.20734326
41Phototransduction_Homo sapiens_hsa047441.20296804
42Endometrial cancer_Homo sapiens_hsa052131.19504366
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18278448
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.17853537
45Estrogen signaling pathway_Homo sapiens_hsa049151.16005205
46Dilated cardiomyopathy_Homo sapiens_hsa054141.15573136
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14355997
48Oocyte meiosis_Homo sapiens_hsa041141.12926682
49ErbB signaling pathway_Homo sapiens_hsa040121.12762593
50Lysine degradation_Homo sapiens_hsa003101.08269332
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06346842
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.03346482
53mTOR signaling pathway_Homo sapiens_hsa041501.03312343
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98985610
55Regulation of autophagy_Homo sapiens_hsa041400.98935108
56Wnt signaling pathway_Homo sapiens_hsa043100.98898693
57Ovarian steroidogenesis_Homo sapiens_hsa049130.96051687
58Hippo signaling pathway_Homo sapiens_hsa043900.95647571
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94954804
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94888766
61Hedgehog signaling pathway_Homo sapiens_hsa043400.94750991
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93323569
63Colorectal cancer_Homo sapiens_hsa052100.92825915
64Dorso-ventral axis formation_Homo sapiens_hsa043200.91126637
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90982657
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90033744
67Renal cell carcinoma_Homo sapiens_hsa052110.89952669
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88631573
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87936902
70Choline metabolism in cancer_Homo sapiens_hsa052310.86202412
71Rap1 signaling pathway_Homo sapiens_hsa040150.86105197
72Non-small cell lung cancer_Homo sapiens_hsa052230.83959013
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83362581
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82851137
75MAPK signaling pathway_Homo sapiens_hsa040100.82566427
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.82034245
77Propanoate metabolism_Homo sapiens_hsa006400.81521261
78Tryptophan metabolism_Homo sapiens_hsa003800.80213397
79Alcoholism_Homo sapiens_hsa050340.80036208
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79766150
81Ras signaling pathway_Homo sapiens_hsa040140.77606235
82Basal cell carcinoma_Homo sapiens_hsa052170.77407633
83Adherens junction_Homo sapiens_hsa045200.76410046
84ABC transporters_Homo sapiens_hsa020100.74119298
85Pancreatic secretion_Homo sapiens_hsa049720.74116161
86Steroid biosynthesis_Homo sapiens_hsa001000.71556238
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.70059051
88Ether lipid metabolism_Homo sapiens_hsa005650.69969758
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69932014
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66477871
91Melanoma_Homo sapiens_hsa052180.64959001
92Collecting duct acid secretion_Homo sapiens_hsa049660.64844950
93Glucagon signaling pathway_Homo sapiens_hsa049220.64310151
94VEGF signaling pathway_Homo sapiens_hsa043700.64087960
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63607530
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63110162
97Basal transcription factors_Homo sapiens_hsa030220.62802846
98Selenocompound metabolism_Homo sapiens_hsa004500.62068299
99Prolactin signaling pathway_Homo sapiens_hsa049170.61543850
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59487420
101Insulin signaling pathway_Homo sapiens_hsa049100.59197925
102Thyroid hormone synthesis_Homo sapiens_hsa049180.58380613
103Tight junction_Homo sapiens_hsa045300.58259332
104Vitamin B6 metabolism_Homo sapiens_hsa007500.57121600
105AMPK signaling pathway_Homo sapiens_hsa041520.56648469
106Fatty acid metabolism_Homo sapiens_hsa012120.56365472
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55949666
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55787645
109Cardiac muscle contraction_Homo sapiens_hsa042600.55503979
110Pancreatic cancer_Homo sapiens_hsa052120.53332814
111MicroRNAs in cancer_Homo sapiens_hsa052060.52365913
112TGF-beta signaling pathway_Homo sapiens_hsa043500.51518472
113Vibrio cholerae infection_Homo sapiens_hsa051100.50556221
114Type I diabetes mellitus_Homo sapiens_hsa049400.49840986
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48959361
116FoxO signaling pathway_Homo sapiens_hsa040680.47884525
117Chronic myeloid leukemia_Homo sapiens_hsa052200.47738782
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47602743
119Protein digestion and absorption_Homo sapiens_hsa049740.47402975
120Thyroid cancer_Homo sapiens_hsa052160.47382422
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47008910
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47008313
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.46597301
124Bile secretion_Homo sapiens_hsa049760.46591142
125beta-Alanine metabolism_Homo sapiens_hsa004100.46233948
126Oxidative phosphorylation_Homo sapiens_hsa001900.43013161
127Fanconi anemia pathway_Homo sapiens_hsa034600.42812498
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41935338
129Prostate cancer_Homo sapiens_hsa052150.41837220
130Proteoglycans in cancer_Homo sapiens_hsa052050.41328241
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.41182511

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