MEIS3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.36263031
2hemidesmosome assembly (GO:0031581)4.05693721
3skin morphogenesis (GO:0043589)4.01505482
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.94648586
5protein heterotrimerization (GO:0070208)3.87591589
6dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.83183037
7collagen fibril organization (GO:0030199)3.61021871
8COPI coating of Golgi vesicle (GO:0048205)3.57978877
9Golgi transport vesicle coating (GO:0048200)3.57978877
10protein retention in ER lumen (GO:0006621)3.52290434
11paraxial mesoderm development (GO:0048339)3.50945001
12negative regulation of chondrocyte differentiation (GO:0032331)3.48385334
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.47020623
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.47018850
15cell-substrate junction assembly (GO:0007044)3.46241947
16epithelial cell-cell adhesion (GO:0090136)3.38014439
17endodermal cell differentiation (GO:0035987)3.37048348
18type B pancreatic cell proliferation (GO:0044342)3.27702521
19basement membrane organization (GO:0071711)3.26636349
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.25536391
21axon extension involved in axon guidance (GO:0048846)3.25536391
22mesenchymal-epithelial cell signaling (GO:0060638)3.22035825
23cell adhesion mediated by integrin (GO:0033627)3.21490261
24Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.20940257
25regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.15457909
26vascular endothelial growth factor signaling pathway (GO:0038084)3.14942889
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.14534822
28kidney mesenchyme development (GO:0072074)3.13440118
29adherens junction assembly (GO:0034333)3.12842202
30cell migration involved in heart development (GO:0060973)3.07149445
31glomerular basement membrane development (GO:0032836)3.03757368
32chondrocyte proliferation (GO:0035988)3.02278066
33metanephric mesenchyme development (GO:0072075)3.02053485
34extracellular fibril organization (GO:0043206)3.01708793
35regulation of establishment of planar polarity (GO:0090175)3.00623759
36collagen metabolic process (GO:0032963)2.97926040
37focal adhesion assembly (GO:0048041)2.96802398
38cell-substrate adherens junction assembly (GO:0007045)2.96802398
39endothelial cell morphogenesis (GO:0001886)2.96196695
40cell migration involved in sprouting angiogenesis (GO:0002042)2.94712973
41bone trabecula formation (GO:0060346)2.94507752
42muscle cell migration (GO:0014812)2.93998947
43facial nerve structural organization (GO:0021612)2.90045631
44extracellular matrix assembly (GO:0085029)2.88683273
45regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85074668
46retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85058960
47myoblast fusion (GO:0007520)2.82125547
48barbed-end actin filament capping (GO:0051016)2.81532624
49endothelial cell chemotaxis (GO:0035767)2.80596010
50desmosome organization (GO:0002934)2.79234837
51apoptotic cell clearance (GO:0043277)2.78660168
52lateral sprouting from an epithelium (GO:0060601)2.78334177
53multicellular organismal macromolecule metabolic process (GO:0044259)2.78076997
54branching involved in salivary gland morphogenesis (GO:0060445)2.77928032
55collagen catabolic process (GO:0030574)2.77838502
56negative regulation of cartilage development (GO:0061037)2.76581656
57non-canonical Wnt signaling pathway (GO:0035567)2.76384957
58establishment of tissue polarity (GO:0007164)2.75646564
59establishment of planar polarity (GO:0001736)2.75646564
60hippo signaling (GO:0035329)2.68738243
61cochlea morphogenesis (GO:0090103)2.68695289
62notochord development (GO:0030903)2.66568735
63protein localization to cell surface (GO:0034394)2.66382351
64substrate-dependent cell migration (GO:0006929)2.64936101
65extracellular matrix disassembly (GO:0022617)2.63416847
66syncytium formation by plasma membrane fusion (GO:0000768)2.63297205
67positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62961158
68multicellular organismal metabolic process (GO:0044236)2.61644496
69regulation of cardioblast differentiation (GO:0051890)2.60752540
70semaphorin-plexin signaling pathway (GO:0071526)2.58943490
71positive regulation of osteoblast proliferation (GO:0033690)2.58837346
72regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57521068
73insulin-like growth factor receptor signaling pathway (GO:0048009)2.57233230
74establishment of apical/basal cell polarity (GO:0035089)2.57087100
75negative regulation of fatty acid transport (GO:2000192)2.56078644
76regulation of glucose import in response to insulin stimulus (GO:2001273)2.55609216
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.55400138
78convergent extension (GO:0060026)2.54949872
79atrial septum morphogenesis (GO:0060413)2.53240442
80multicellular organismal catabolic process (GO:0044243)2.52236198
81wound healing, spreading of cells (GO:0044319)2.51677300
82positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.49753463
83protein maturation by protein folding (GO:0022417)2.49692253
84wound healing, spreading of epidermal cells (GO:0035313)2.47800492
85fibril organization (GO:0097435)2.44253487
86negative regulation of smooth muscle cell migration (GO:0014912)2.43949550
87positive regulation of endothelial cell apoptotic process (GO:2000353)2.41855751
88cellular response to vitamin (GO:0071295)2.40573377
89mesodermal cell differentiation (GO:0048333)2.40350982
90sequestering of extracellular ligand from receptor (GO:0035581)2.39775865
91blood vessel endothelial cell migration (GO:0043534)2.39744392
92regulation of transforming growth factor beta2 production (GO:0032909)2.39114612
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.38210882
94gap junction assembly (GO:0016264)2.37467052
95glial cell migration (GO:0008347)2.36291300
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36153742
97axon extension (GO:0048675)2.36062539
98extracellular matrix organization (GO:0030198)2.34856928
99camera-type eye morphogenesis (GO:0048593)2.34812915
100cell proliferation involved in metanephros development (GO:0072203)2.34673876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.07001388
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.41347806
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.01685038
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.42436449
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23371965
6CLOCK_20551151_ChIP-Seq_293T_Human2.93968746
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.88562584
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67352425
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.59954150
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.40509797
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.36468113
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.22902441
13ZNF263_19887448_ChIP-Seq_K562_Human2.21316131
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.21304010
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.19787563
16AR_21909140_ChIP-Seq_LNCAP_Human2.16322826
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.01184917
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00163833
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00101816
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97627053
21RACK7_27058665_Chip-Seq_MCF-7_Human1.86672689
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84815348
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83283965
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.80793712
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80745260
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71980597
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68540785
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.67298842
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65849797
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63777320
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61259112
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59877179
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.59396512
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58607078
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58574825
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48668760
37LXR_22292898_ChIP-Seq_THP-1_Human1.47395480
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46767566
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46767566
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45333288
41TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44656299
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.41615672
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40220759
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39861397
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39285900
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38103737
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37764587
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.36646925
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.34984585
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33362159
51KDM2B_26808549_Chip-Seq_K562_Human1.32789024
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.32135687
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.32135687
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.30396077
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29633514
56CJUN_26792858_Chip-Seq_BT549_Human1.27895544
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.26521330
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.25927652
59TP53_22127205_ChIP-Seq_IMR90_Human1.25485064
60SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24510851
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23478486
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22998046
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22794252
64ATF3_27146783_Chip-Seq_COLON_Human1.22439259
65TP53_23651856_ChIP-Seq_MEFs_Mouse1.17750195
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16521263
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16521263
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16315040
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16228435
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15314733
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15063155
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14752306
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.13091374
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10517994
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09173659
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07167409
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06138748
78AHR_22903824_ChIP-Seq_MCF-7_Human1.05232029
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04380608
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.04300339
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03731882
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02707647
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02628189
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02087921
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.01905020
86SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00926888
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00281012
88FOXM1_23109430_ChIP-Seq_U2OS_Human0.99430436
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99045334
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98192567
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96695386
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96590978
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96190041
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95628464
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93277394
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92620294
97SA1_22415368_ChIP-Seq_MEFs_Mouse0.92047957
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91758793
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90768136
100KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90051563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.76818126
2MP0003705_abnormal_hypodermis_morpholog4.25747184
3MP0004272_abnormal_basement_membrane3.80439872
4MP0005503_abnormal_tendon_morphology3.57945282
5MP0010030_abnormal_orbit_morphology3.48620529
6MP0005257_abnormal_intraocular_pressure3.30810493
7MP0005275_abnormal_skin_tensile3.19567822
8MP0001958_emphysema2.88891952
9MP0003566_abnormal_cell_adhesion2.75805793
10MP0003279_aneurysm2.28643992
11MP0000751_myopathy2.26871487
12MP0003941_abnormal_skin_development2.07490177
13MP0002877_abnormal_melanocyte_morpholog1.99093731
14MP0005623_abnormal_meninges_morphology1.98834227
15MP0009384_cardiac_valve_regurgitation1.98081958
16MP0010368_abnormal_lymphatic_system1.96503644
17MP0000537_abnormal_urethra_morphology1.93831266
18MP0001849_ear_inflammation1.88988598
19MP0001299_abnormal_eye_distance/1.85620935
20MP0000566_synostosis1.83835258
21MP0005508_abnormal_skeleton_morphology1.82648164
22MP0002060_abnormal_skin_morphology1.75722821
23MP0004858_abnormal_nervous_system1.73833179
24MP0002295_abnormal_pulmonary_circulatio1.64718791
25MP0002108_abnormal_muscle_morphology1.60649122
26MP0009780_abnormal_chondrocyte_physiolo1.55409575
27MP0000534_abnormal_ureter_morphology1.53432306
28MP0000579_abnormal_nail_morphology1.50247972
29MP0003091_abnormal_cell_migration1.50018813
30MP0000762_abnormal_tongue_morphology1.46093008
31MP0005171_absent_coat_pigmentation1.44059967
32MP0005023_abnormal_wound_healing1.41502085
33MP0001542_abnormal_bone_strength1.38211637
34MP0002249_abnormal_larynx_morphology1.36104375
35MP0006054_spinal_hemorrhage1.34644790
36MP0000462_abnormal_digestive_system1.31498014
37MP0002896_abnormal_bone_mineralization1.30392671
38MP0002697_abnormal_eye_size1.25718226
39MP0004233_abnormal_muscle_weight1.25512448
40MP0000767_abnormal_smooth_muscle1.24830151
41MP0003942_abnormal_urinary_system1.23928334
42MP0000013_abnormal_adipose_tissue1.23579045
43MP0009053_abnormal_anal_canal1.21595518
44MP0000733_abnormal_muscle_development1.20883435
45MP0010352_gastrointestinal_tract_polyps1.17370431
46MP0009250_abnormal_appendicular_skeleto1.16902121
47MP0000428_abnormal_craniofacial_morphol1.16105502
48MP0003115_abnormal_respiratory_system1.13930350
49MP0000049_abnormal_middle_ear1.13106596
50MP0005409_darkened_coat_color1.10842442
51MP0003385_abnormal_body_wall1.10659388
52MP0001243_abnormal_dermal_layer1.10639907
53MP0005248_abnormal_Harderian_gland1.08904855
54MP0000750_abnormal_muscle_regeneration1.07010585
55MP0000749_muscle_degeneration1.02797784
56MP0005197_abnormal_uvea_morphology1.00605837
57MP0003937_abnormal_limbs/digits/tail_de0.99151691
58MP0000467_abnormal_esophagus_morphology0.99123764
59MP0005076_abnormal_cell_differentiation0.98336544
60MP0001879_abnormal_lymphatic_vessel0.98315179
61MP0006138_congestive_heart_failure0.96467351
62MP0000163_abnormal_cartilage_morphology0.95419507
63MP0000003_abnormal_adipose_tissue0.92282407
64MP0000759_abnormal_skeletal_muscle0.89772659
65MP0003755_abnormal_palate_morphology0.89610839
66MP0002116_abnormal_craniofacial_bone0.86909462
67MP0005595_abnormal_vascular_smooth0.86815971
68MP0003283_abnormal_digestive_organ0.84476808
69MP0002282_abnormal_trachea_morphology0.81859258
70MP0005193_abnormal_anterior_eye0.81633789
71MP0000747_muscle_weakness0.80096503
72MP0000432_abnormal_head_morphology0.79535744
73MP0000627_abnormal_mammary_gland0.79255033
74MP0004087_abnormal_muscle_fiber0.79084107
75MP0003950_abnormal_plasma_membrane0.78307333
76MP0002796_impaired_skin_barrier0.76926786
77MP0004084_abnormal_cardiac_muscle0.75361352
78MP0002092_abnormal_eye_morphology0.74527498
79MP0005501_abnormal_skin_physiology0.73473138
80MP0002932_abnormal_joint_morphology0.73218598
81MP0003935_abnormal_craniofacial_develop0.73186635
82MP0001348_abnormal_lacrimal_gland0.72107488
83MP0005390_skeleton_phenotype0.71191272
84MP0002128_abnormal_blood_circulation0.70982513
85MP0001614_abnormal_blood_vessel0.70856333
86MP0002085_abnormal_embryonic_tissue0.70587033
87MP0002925_abnormal_cardiovascular_devel0.67641883
88MP0010630_abnormal_cardiac_muscle0.67209221
89MP0001661_extended_life_span0.65746417
90MP0002254_reproductive_system_inflammat0.65491237
91MP0002113_abnormal_skeleton_development0.65219035
92MP0005058_abnormal_lysosome_morphology0.65183415
93MP0002115_abnormal_skeleton_extremities0.65078648
94MP0004782_abnormal_surfactant_physiolog0.64621977
95MP0009672_abnormal_birth_weight0.63494065
96MP0005330_cardiomyopathy0.63181613
97MP0002938_white_spotting0.62498976
98MP0003453_abnormal_keratinocyte_physiol0.61462382
99MP0002233_abnormal_nose_morphology0.60477819
100MP0010771_integument_phenotype0.60419325

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.15275888
2Protrusio acetabuli (HP:0003179)5.59735738
3Vascular tortuosity (HP:0004948)3.95938930
4Arterial tortuosity (HP:0005116)3.74490727
5Shallow orbits (HP:0000586)3.63853455
6Ankle contracture (HP:0006466)3.53302603
7Aortic dissection (HP:0002647)3.45947586
8Abnormality of dentin (HP:0010299)3.43780528
9Atrophic scars (HP:0001075)3.42651803
10Cervical subluxation (HP:0003308)3.36391998
11Bladder diverticulum (HP:0000015)3.34908389
12Spinal rigidity (HP:0003306)3.33266845
13Aortic aneurysm (HP:0004942)3.21065223
14Short nail (HP:0001799)3.11400617
15Vertebral compression fractures (HP:0002953)3.09235497
16Broad metatarsal (HP:0001783)3.02814519
17Soft skin (HP:0000977)3.01439461
18Wormian bones (HP:0002645)2.92307691
19Ulnar bowing (HP:0003031)2.84714530
20Increased connective tissue (HP:0009025)2.76775753
21Hyperacusis (HP:0010780)2.76306226
22Fragile skin (HP:0001030)2.74973172
23Type 1 muscle fiber predominance (HP:0003803)2.70047823
24Mildly elevated creatine phosphokinase (HP:0008180)2.68909204
25Blue sclerae (HP:0000592)2.64506206
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.61293670
27Osteolytic defects of the hand bones (HP:0009699)2.61293670
28Neonatal short-limb short stature (HP:0008921)2.58114859
29Broad face (HP:0000283)2.54173686
30Biconcave vertebral bodies (HP:0004586)2.48371978
31Aplasia involving bones of the extremities (HP:0009825)2.43023067
32Aplasia involving bones of the upper limbs (HP:0009823)2.43023067
33Aplasia of the phalanges of the hand (HP:0009802)2.43023067
34Cerebral aneurysm (HP:0004944)2.39834942
35Absent frontal sinuses (HP:0002688)2.36033627
36Follicular hyperkeratosis (HP:0007502)2.35559642
37Distal lower limb muscle weakness (HP:0009053)2.30960957
38Joint laxity (HP:0001388)2.30109595
39Coronal craniosynostosis (HP:0004440)2.22941863
40Distal lower limb amyotrophy (HP:0008944)2.22155196
41Abnormality of the distal phalanges of the toes (HP:0010182)2.21161223
42Increased variability in muscle fiber diameter (HP:0003557)2.19739958
43Natal tooth (HP:0000695)2.18242989
44Mitral regurgitation (HP:0001653)2.14833762
45Dilatation of the ascending aorta (HP:0005111)2.14747579
46Hyperextensible skin (HP:0000974)2.14175753
47Thin ribs (HP:0000883)2.14088779
48Aortic regurgitation (HP:0001659)2.12458398
49Genu recurvatum (HP:0002816)2.10799714
50Congenital glaucoma (HP:0001087)2.08936192
51Bowel diverticulosis (HP:0005222)2.08731829
52Elbow flexion contracture (HP:0002987)2.06502070
53Slender build (HP:0001533)2.05460903
54Difficulty climbing stairs (HP:0003551)2.05062370
55Mitral valve prolapse (HP:0001634)2.02270283
56Buphthalmos (HP:0000557)2.00874335
57Termporal pattern (HP:0011008)1.96883730
58Insidious onset (HP:0003587)1.96883730
59Disproportionate tall stature (HP:0001519)1.96746580
60Spinal cord compression (HP:0002176)1.95921047
61Wide anterior fontanel (HP:0000260)1.94894306
62Long toe (HP:0010511)1.94314630
63Partial duplication of the phalanx of hand (HP:0009999)1.93661888
64Distal upper limb amyotrophy (HP:0007149)1.92093805
65Upper limb amyotrophy (HP:0009129)1.92093805
66Breech presentation (HP:0001623)1.91664929
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90171738
68Wrist flexion contracture (HP:0001239)1.89972857
69Abnormality of the acetabulum (HP:0003170)1.89491734
70Mitral stenosis (HP:0001718)1.88780611
71Overriding aorta (HP:0002623)1.85102332
72Generalized amyotrophy (HP:0003700)1.85005038
73Abnormality of skeletal muscle fiber size (HP:0012084)1.84961943
74Pulmonary artery stenosis (HP:0004415)1.84918280
75Pterygium (HP:0001059)1.84000294
76Delayed cranial suture closure (HP:0000270)1.82663942
77Abnormal delivery (HP:0001787)1.81029885
78Aneurysm (HP:0002617)1.80648576
79Achilles tendon contracture (HP:0001771)1.80520254
80Hallux valgus (HP:0001822)1.80287152
81Lower limb amyotrophy (HP:0007210)1.80121926
82Deviation of the hallux (HP:0010051)1.79700759
83Turricephaly (HP:0000262)1.79530254
84Spondylolisthesis (HP:0003302)1.79344628
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.79135417
86Hypoventilation (HP:0002791)1.78890911
87Thin bony cortex (HP:0002753)1.76010959
88Advanced eruption of teeth (HP:0006288)1.75180234
89Renal duplication (HP:0000075)1.73425421
90Partial duplication of thumb phalanx (HP:0009944)1.72730263
91Limb-girdle muscle weakness (HP:0003325)1.70977176
92Abnormality of the umbilical cord (HP:0010881)1.70513465
93Overgrowth (HP:0001548)1.70023802
94Abnormality of molar (HP:0011077)1.69458670
95Abnormality of molar morphology (HP:0011070)1.69458670
96Bowed forearm bones (HP:0003956)1.69374215
97Bowing of the arm (HP:0006488)1.69374215
98Arnold-Chiari malformation (HP:0002308)1.69368680
99Back pain (HP:0003418)1.68984559
100Short clavicles (HP:0000894)1.67533380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.81234411
2EPHA23.50832981
3TTN3.13033997
4MYLK2.92135077
5PDGFRA2.90244383
6PAK42.80818199
7TESK12.73609427
8SIK12.67802685
9PKN22.58917709
10EPHB22.30725458
11PTK22.27663825
12SMG12.22938287
13NTRK12.21017193
14LATS12.18928552
15EPHB12.14576980
16EPHA32.03379874
17MET2.01972816
18LATS21.98880876
19DDR21.92305340
20RIPK11.87795309
21ICK1.81709844
22LMTK21.74056818
23MST1R1.73190336
24LIMK11.72928788
25PAK21.46313848
26FLT31.36288021
27SCYL21.19895521
28PRKD31.19382933
29NEK91.18546164
30PTK61.18429226
31ILK1.16120323
32IRAK31.12438058
33EEF2K1.12071499
34ERN11.10656058
35ERBB41.08450734
36RPS6KA21.02974421
37MAP3K31.01271657
38MAP3K61.00881604
39STK380.96883624
40MTOR0.93062795
41PRKD20.91176846
42TGFBR20.90492832
43PDGFRB0.88869077
44DMPK0.87282966
45ROCK20.85838471
46ARAF0.80745637
47ABL20.75580001
48BRSK10.73574057
49CAMK2G0.72619674
50RET0.72070363
51CAMK2B0.71555620
52CDC42BPA0.67961110
53LRRK20.67366998
54FGFR40.66614670
55NME20.66205764
56PIM20.64530971
57MUSK0.61804089
58MOS0.60901365
59DAPK30.57304433
60FER0.56785610
61BUB10.54470207
62BMX0.54458122
63MAP2K10.54434039
64STK30.53463827
65TESK20.53387477
66CDK80.52939168
67STK38L0.51391702
68ROCK10.50878516
69PRKG20.50612305
70RPS6KB20.49914835
71CDK70.49550612
72GSK3A0.48770140
73TRPM70.48265208
74CDK90.46101481
75PAK10.45390332
76MAP3K120.45260398
77MINK10.41834545
78PAK60.41001896
79MAPKAPK30.40710373
80CAMK2D0.39725049
81BRSK20.38608185
82CDK180.36322757
83CDK150.35409912
84PBK0.34265805
85PRKD10.34048795
86AURKA0.33787393
87AKT20.33524025
88GRK10.32128534
89BCR0.31415248
90MAPKAPK20.30760518
91CDK60.30390372
92KSR20.30239770
93RPS6KL10.29454096
94RPS6KC10.29454096
95CDK11A0.29159254
96MAPK150.29148652
97TAOK20.28923172
98NEK10.28625015
99MAP3K20.28346998
100PTK2B0.28185413

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.71503502
2Focal adhesion_Homo sapiens_hsa045102.58015388
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.42691704
4Basal cell carcinoma_Homo sapiens_hsa052172.20432830
5Dilated cardiomyopathy_Homo sapiens_hsa054142.01691408
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96637936
7Proteoglycans in cancer_Homo sapiens_hsa052051.91453504
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.90687866
9Hippo signaling pathway_Homo sapiens_hsa043901.87602811
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85245468
11Hedgehog signaling pathway_Homo sapiens_hsa043401.81413239
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80934802
13Small cell lung cancer_Homo sapiens_hsa052221.79795354
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.73611247
15Adherens junction_Homo sapiens_hsa045201.68046680
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65398493
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59734492
18Amoebiasis_Homo sapiens_hsa051461.59265895
19Bladder cancer_Homo sapiens_hsa052191.54326441
20Tight junction_Homo sapiens_hsa045301.52152482
21Thyroid cancer_Homo sapiens_hsa052161.45048641
22Axon guidance_Homo sapiens_hsa043601.43292275
23Protein digestion and absorption_Homo sapiens_hsa049741.41760086
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40992008
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36135279
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32982300
27Melanogenesis_Homo sapiens_hsa049161.31946269
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.31315471
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.28219006
30Melanoma_Homo sapiens_hsa052181.27045784
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26628023
32Notch signaling pathway_Homo sapiens_hsa043301.21876748
33Gap junction_Homo sapiens_hsa045401.17828597
34MicroRNAs in cancer_Homo sapiens_hsa052061.17777421
35Pentose phosphate pathway_Homo sapiens_hsa000301.17521100
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15026652
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14172288
38Pathways in cancer_Homo sapiens_hsa052001.13689931
39Chronic myeloid leukemia_Homo sapiens_hsa052201.12768871
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10450950
41Endometrial cancer_Homo sapiens_hsa052131.09810087
42TGF-beta signaling pathway_Homo sapiens_hsa043501.06845919
43Galactose metabolism_Homo sapiens_hsa000521.03537884
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02347989
45Wnt signaling pathway_Homo sapiens_hsa043100.99666016
46N-Glycan biosynthesis_Homo sapiens_hsa005100.99201019
47Prostate cancer_Homo sapiens_hsa052150.96803714
48AMPK signaling pathway_Homo sapiens_hsa041520.95341777
49Vibrio cholerae infection_Homo sapiens_hsa051100.95303340
50Biosynthesis of amino acids_Homo sapiens_hsa012300.94889345
51Glioma_Homo sapiens_hsa052140.94752302
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94726379
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92874621
54Pyruvate metabolism_Homo sapiens_hsa006200.92707244
55Phenylalanine metabolism_Homo sapiens_hsa003600.92115740
56Pancreatic cancer_Homo sapiens_hsa052120.86189974
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85771281
58Prion diseases_Homo sapiens_hsa050200.84075481
59Steroid biosynthesis_Homo sapiens_hsa001000.80521867
60Renal cell carcinoma_Homo sapiens_hsa052110.79292559
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77736923
62Insulin signaling pathway_Homo sapiens_hsa049100.77723337
63Glutathione metabolism_Homo sapiens_hsa004800.76168296
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.75951056
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75927928
66Rap1 signaling pathway_Homo sapiens_hsa040150.75479259
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73753652
68ErbB signaling pathway_Homo sapiens_hsa040120.71709805
69Vitamin B6 metabolism_Homo sapiens_hsa007500.71423827
70Tyrosine metabolism_Homo sapiens_hsa003500.68898836
71Carbon metabolism_Homo sapiens_hsa012000.66332044
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65646059
73Estrogen signaling pathway_Homo sapiens_hsa049150.65473403
74Thyroid hormone synthesis_Homo sapiens_hsa049180.65374789
75Other glycan degradation_Homo sapiens_hsa005110.58966802
76Endocytosis_Homo sapiens_hsa041440.57137655
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56359555
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55760574
79Lysine degradation_Homo sapiens_hsa003100.54014808
80Colorectal cancer_Homo sapiens_hsa052100.51014736
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50344199
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.50312156
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.47686395
84Fructose and mannose metabolism_Homo sapiens_hsa000510.46810951
85mTOR signaling pathway_Homo sapiens_hsa041500.46237614
86Sulfur relay system_Homo sapiens_hsa041220.45789490
87Lysosome_Homo sapiens_hsa041420.44585788
88Non-small cell lung cancer_Homo sapiens_hsa052230.44325919
89VEGF signaling pathway_Homo sapiens_hsa043700.40921652
90p53 signaling pathway_Homo sapiens_hsa041150.38973218
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38944386
92Sphingolipid metabolism_Homo sapiens_hsa006000.38038375
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35828774
94Glucagon signaling pathway_Homo sapiens_hsa049220.35258594
95HTLV-I infection_Homo sapiens_hsa051660.35041644
96Cocaine addiction_Homo sapiens_hsa050300.34572811
97Ras signaling pathway_Homo sapiens_hsa040140.34053278
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32883209
99GnRH signaling pathway_Homo sapiens_hsa049120.32841762
100Choline metabolism in cancer_Homo sapiens_hsa052310.32787345

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