ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.09134524
2	microtubule depolymerization (GO:0007019)	4.40747607
3	melanin biosynthetic process (GO:0042438)	4.39477897
4	axonemal dynein complex assembly (GO:0070286)	4.17755302
5	protein neddylation (GO:0045116)	4.01831397
6	fatty acid elongation (GO:0030497)	3.85683218
7	platelet aggregation (GO:0070527)	3.81037975
8	paraxial mesoderm development (GO:0048339)	3.69290994
9	regulation of integrin-mediated signaling pathway (GO:2001044)	3.62649918
10	melanin metabolic process (GO:0006582)	3.58699315
11	regulation of mitotic spindle organization (GO:0060236)	3.58664645
12	ventricular cardiac muscle cell development (GO:0055015)	3.46116841
13	secondary metabolite biosynthetic process (GO:0044550)	3.44489631
14	kinetochore organization (GO:0051383)	3.34473110
15	response to insecticide (GO:0017085)	3.28518398
16	positive regulation of catenin import into nucleus (GO:0035413)	3.22375674
17	regulation of integrin activation (GO:0033623)	3.21963886
18	meiotic chromosome segregation (GO:0045132)	3.20645932
19	regulation of cilium movement (GO:0003352)	3.20426727
20	epithelial cell-cell adhesion (GO:0090136)	3.16838342
21	convergent extension (GO:0060026)	3.14467655
22	asymmetric protein localization (GO:0008105)	3.08372799
23	positive regulation of neuroblast proliferation (GO:0002052)	3.04805381
24	extracellular fibril organization (GO:0043206)	3.04781829
25	thrombin receptor signaling pathway (GO:0070493)	3.00849883
26	blood coagulation, intrinsic pathway (GO:0007597)	3.00225373
27	positive regulation of endothelial cell differentiation (GO:0045603)	3.00009791
28	resolution of meiotic recombination intermediates (GO:0000712)	2.99003996
29	epithelial cilium movement (GO:0003351)	2.96213892
30	positive regulation of Rho protein signal transduction (GO:0035025)	2.95585632
31	platelet degranulation (GO:0002576)	2.95498359
32	heparin biosynthetic process (GO:0030210)	2.92883300
33	heparin metabolic process (GO:0030202)	2.92883300
34	cilium movement (GO:0003341)	2.90899924
35	microtubule polymerization or depolymerization (GO:0031109)	2.90685932
36	negative regulation of meiosis (GO:0045835)	2.89987444
37	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.89890413
38	regulation of transforming growth factor beta2 production (GO:0032909)	2.87375466
39	apical protein localization (GO:0045176)	2.86528165
40	regulation of meiosis I (GO:0060631)	2.83838215
41	myelin assembly (GO:0032288)	2.82770171
42	regulation of early endosome to late endosome transport (GO:2000641)	2.81395472
43	regulation of gene silencing by miRNA (GO:0060964)	2.78947869
44	regulation of gene silencing by RNA (GO:0060966)	2.78947869
45	regulation of posttranscriptional gene silencing (GO:0060147)	2.78947869
46	negative chemotaxis (GO:0050919)	2.76883389
47	protein localization to cell surface (GO:0034394)	2.76097497
48	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75912075
49	positive regulation of myoblast differentiation (GO:0045663)	2.75862553
50	dopamine biosynthetic process (GO:0042416)	2.69908849
51	protein complex localization (GO:0031503)	2.69863935
52	mitotic chromosome condensation (GO:0007076)	2.68554071
53	negative regulation of norepinephrine secretion (GO:0010700)	2.68430790
54	protein localization to microtubule (GO:0035372)	2.67931367
55	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.67571137
56	positive regulation of receptor recycling (GO:0001921)	2.67049426
57	cell-cell junction maintenance (GO:0045217)	2.66605066
58	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.65297548
59	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.64228886
60	myelination in peripheral nervous system (GO:0022011)	2.60442774
61	peripheral nervous system axon ensheathment (GO:0032292)	2.60442774
62	atrial septum morphogenesis (GO:0060413)	2.59447598
63	regulation of sister chromatid cohesion (GO:0007063)	2.59009129
64	inner ear receptor cell development (GO:0060119)	2.57820784
65	fusion of sperm to egg plasma membrane (GO:0007342)	2.53018405
66	phenol-containing compound biosynthetic process (GO:0046189)	2.52586628
67	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.52576559
68	heart contraction (GO:0060047)	2.50812350
69	heart process (GO:0003015)	2.50812350
70	serotonin metabolic process (GO:0042428)	2.49980719
71	fibroblast migration (GO:0010761)	2.49725510
72	establishment of apical/basal cell polarity (GO:0035089)	2.49431206
73	mitotic metaphase plate congression (GO:0007080)	2.49073703
74	outer ear morphogenesis (GO:0042473)	2.48268686
75	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.46271120
76	toxin metabolic process (GO:0009404)	2.45630284
77	homotypic cell-cell adhesion (GO:0034109)	2.44863836
78	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.43060754
79	negative regulation of neural precursor cell proliferation (GO:2000178)	2.42577925
80	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.41787788
81	regulation of spindle organization (GO:0090224)	2.41316861
82	cellular biogenic amine biosynthetic process (GO:0042401)	2.40449239
83	positive regulation of actin filament depolymerization (GO:0030836)	2.38141238
84	hippo signaling (GO:0035329)	2.38076052
85	adenosine receptor signaling pathway (GO:0001973)	2.37057239
86	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.32928080
87	establishment or maintenance of bipolar cell polarity (GO:0061245)	2.32928080
88	positive regulation of neural precursor cell proliferation (GO:2000179)	2.31887865
89	positive regulation of focal adhesion assembly (GO:0051894)	2.31792863
90	positive regulation of cell junction assembly (GO:1901890)	2.31792863
91	establishment of nucleus localization (GO:0040023)	2.31405367
92	cell junction maintenance (GO:0034331)	2.30643540
93	establishment of planar polarity (GO:0001736)	2.30165704
94	establishment of tissue polarity (GO:0007164)	2.30165704
95	tyrosine metabolic process (GO:0006570)	2.29324623
96	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.29111558
97	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.28917286
98	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.28785222
99	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.28435205
100	notochord development (GO:0030903)	2.27980569

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.89426969
2	AR_21909140_ChIP-Seq_LNCAP_Human	3.66734407
3	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	3.42714284
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.80075422
5	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.74740250
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.60251341
7	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.47907182
8	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.45995633
9	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.39826654
10	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.34764514
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.32588125
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.17078159
13	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.10154630
14	VDR_22108803_ChIP-Seq_LS180_Human	1.93320333
15	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.76434859
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.74605602
17	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.70030125
18	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.63919121
19	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.60796210
20	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.60716858
21	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.60572927
22	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.59767311
23	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.58376266
24	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.57455115
25	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.54618684
26	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.47153814
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.43642915
28	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.42395381
29	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.41407997
30	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.40787091
31	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.39666145
32	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.35530089
33	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.34590283
34	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33191096
35	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.33113217
36	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.32420251
37	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.28722022
38	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.28194859
39	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.26721771
40	E2F7_22180533_ChIP-Seq_HELA_Human	1.26700890
41	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.25805120
42	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	1.25080181
43	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.24702842
44	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.23803002
45	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23745270
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.21830191
47	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.20879492
48	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.18443175
49	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.17964227
50	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.14989264
51	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.14989264
52	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.14392528
53	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.13673864
54	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.08465547
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.07899670
56	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.06891520
57	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06575698
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06397671
59	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.06041364
60	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.05700619
61	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.05085507
62	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04656477
63	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.04534766
64	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03010434
65	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03010434
66	BRD4_25478319_ChIP-Seq_HGPS_Human	1.02717553
67	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.01883006
68	CLOCK_20551151_ChIP-Seq_293T_Human	1.00384203
69	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.00237360
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00027891
71	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.99830550
72	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.98367549
73	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.98032263
74	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.97841961
75	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.96798365
76	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.96268356
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.94198565
78	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.93428083
79	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93126866
80	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.92920900
81	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92486356
82	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.90409039
83	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.89658670
84	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.88257066
85	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.88101509
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.87896651
87	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.87196384
88	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.86685099
89	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.86172741
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85738245
91	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.84563284
92	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.82959944
93	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82440079
94	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.82416557
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81484142
96	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.80467638
97	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.80104330
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.80081752
99	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.79746126
100	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.79387557

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	4.53338311
2	MP0005464_abnormal_platelet_physiology	3.42070100
3	MP0000372_irregular_coat_pigmentation	3.30407457
4	MP0003136_yellow_coat_color	3.18191680
5	MP0008438_abnormal_cutaneous_collagen	2.80377469
6	MP0004272_abnormal_basement_membrane	2.76082002
7	MP0010030_abnormal_orbit_morphology	2.70922948
8	MP0005503_abnormal_tendon_morphology	2.70278634
9	MP0008004_abnormal_stomach_pH	2.62086030
10	MP0005248_abnormal_Harderian_gland	2.55596718
11	MP0003566_abnormal_cell_adhesion	2.50734940
12	MP0005409_darkened_coat_color	2.48783258
13	MP0005257_abnormal_intraocular_pressure	2.42308211
14	MP0001529_abnormal_vocalization	2.41604457
15	MP0009697_abnormal_copulation	1.97196195
16	MP0002877_abnormal_melanocyte_morpholog	1.96516738
17	MP0000537_abnormal_urethra_morphology	1.93991956
18	MP0002938_white_spotting	1.84364865
19	MP0009250_abnormal_appendicular_skeleto	1.84117001
20	MP0009053_abnormal_anal_canal	1.74849857
21	MP0003705_abnormal_hypodermis_morpholog	1.67817646
22	MP0003937_abnormal_limbs/digits/tail_de	1.66552880
23	MP0001958_emphysema	1.63434704
24	MP0005408_hypopigmentation	1.61478193
25	MP0001879_abnormal_lymphatic_vessel	1.60745125
26	MP0001849_ear_inflammation	1.59007047
27	MP0003279_aneurysm	1.56247118
28	MP0002736_abnormal_nociception_after	1.56246255
29	MP0002697_abnormal_eye_size	1.49882476
30	MP0000534_abnormal_ureter_morphology	1.42036594
31	MP0005623_abnormal_meninges_morphology	1.39436445
32	MP0001346_abnormal_lacrimal_gland	1.38882108
33	MP0003941_abnormal_skin_development	1.37521407
34	MP0003878_abnormal_ear_physiology	1.36862185
35	MP0005377_hearing/vestibular/ear_phenot	1.36862185
36	MP0010368_abnormal_lymphatic_system	1.36259577
37	MP0005275_abnormal_skin_tensile	1.33655710
38	MP0005197_abnormal_uvea_morphology	1.31988797
39	MP0005187_abnormal_penis_morphology	1.29942585
40	MP0005508_abnormal_skeleton_morphology	1.28469259
41	MP0006054_spinal_hemorrhage	1.28376993
42	MP0003942_abnormal_urinary_system	1.25122034
43	MP0000428_abnormal_craniofacial_morphol	1.19014910
44	MP0002090_abnormal_vision	1.11915634
45	MP0000579_abnormal_nail_morphology	1.10834690
46	MP0000343_altered_response_to	1.09465840
47	MP0002653_abnormal_ependyma_morphology	1.08380384
48	MP0005023_abnormal_wound_healing	1.06949192
49	MP0005083_abnormal_biliary_tract	1.04605611
50	MP0001293_anophthalmia	1.03657013
51	MP0002233_abnormal_nose_morphology	1.03434821
52	MP0004381_abnormal_hair_follicle	1.02905241
53	MP0004133_heterotaxia	1.02716001
54	MP0001968_abnormal_touch/_nociception	1.01493327
55	MP0009379_abnormal_foot_pigmentation	1.01361346
56	MP0009384_cardiac_valve_regurgitation	1.00886560
57	MP0001851_eye_inflammation	0.94478508
58	MP0002295_abnormal_pulmonary_circulatio	0.92709364
59	MP0002089_abnormal_postnatal_growth/wei	0.92442015
60	MP0005193_abnormal_anterior_eye	0.90946792
61	MP0008932_abnormal_embryonic_tissue	0.88832064
62	MP0001286_abnormal_eye_development	0.88106344
63	MP0003186_abnormal_redox_activity	0.86940478
64	MP0006138_congestive_heart_failure	0.83587240
65	MP0000465_gastrointestinal_hemorrhage	0.82657222
66	MP0009703_decreased_birth_body	0.81865784
67	MP0010352_gastrointestinal_tract_polyps	0.81632596
68	MP0008789_abnormal_olfactory_epithelium	0.81242561
69	MP0002735_abnormal_chemical_nociception	0.80861852
70	MP0003755_abnormal_palate_morphology	0.80194758
71	MP0001299_abnormal_eye_distance/	0.80193324
72	MP0003283_abnormal_digestive_organ	0.79847803
73	MP0002084_abnormal_developmental_patter	0.79740554
74	MP0003385_abnormal_body_wall	0.77186411
75	MP0003861_abnormal_nervous_system	0.74664183
76	MP0005423_abnormal_somatic_nervous	0.73403487
77	MP0002085_abnormal_embryonic_tissue	0.73059197
78	MP0003890_abnormal_embryonic-extraembry	0.72197152
79	MP0009672_abnormal_birth_weight	0.70368704
80	MP0003638_abnormal_response/metabolism_	0.70118919
81	MP0000358_abnormal_cell_content/	0.70045542
82	MP0005394_taste/olfaction_phenotype	0.69535612
83	MP0005499_abnormal_olfactory_system	0.69535612
84	MP0003880_abnormal_central_pattern	0.69472326
85	MP0005165_increased_susceptibility_to	0.69169802
86	MP0002128_abnormal_blood_circulation	0.67978137
87	MP0005075_abnormal_melanosome_morpholog	0.67649708
88	MP0003718_maternal_effect	0.65428438
89	MP0002116_abnormal_craniofacial_bone	0.64702483
90	MP0005386_behavior/neurological_phenoty	0.64376440
91	MP0004924_abnormal_behavior	0.64376440
92	MP0004085_abnormal_heartbeat	0.63998518
93	MP0000751_myopathy	0.63645569
94	MP0000049_abnormal_middle_ear	0.63168550
95	MP0001730_embryonic_growth_arrest	0.63100109
96	MP0000647_abnormal_sebaceous_gland	0.61634751
97	MP0002092_abnormal_eye_morphology	0.61481338
98	MP0000230_abnormal_systemic_arterial	0.59836208
99	MP0000432_abnormal_head_morphology	0.58115345
100	MP0008872_abnormal_physiological_respon	0.57940070

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased mean platelet volume (HP:0011877)	6.37216712
2	Abnormal platelet volume (HP:0011876)	5.63349886
3	Menorrhagia (HP:0000132)	5.40491588
4	Prolonged bleeding time (HP:0003010)	4.94606853
5	Abnormal pupillary function (HP:0007686)	4.71353623
6	Petechiae (HP:0000967)	4.47649773
7	Purpura (HP:0000979)	4.35345548
8	Dyschromatopsia (HP:0007641)	4.27280977
9	Abnormal respiratory epithelium morphology (HP:0012253)	3.87699117
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.87699117
11	Cutaneous melanoma (HP:0012056)	3.64191789
12	Abnormal ciliary motility (HP:0012262)	3.58832428
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.23967504
14	Rhinitis (HP:0012384)	3.19738760
15	Epistaxis (HP:0000421)	3.11489424
16	Hypothermia (HP:0002045)	3.00435417
17	Absent/shortened dynein arms (HP:0200106)	2.99582621
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99582621
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.92546847
20	Termporal pattern (HP:0011008)	2.90578995
21	Insidious onset (HP:0003587)	2.90578995
22	Vascular tortuosity (HP:0004948)	2.90031527
23	Protrusio acetabuli (HP:0003179)	2.89722610
24	Gingival bleeding (HP:0000225)	2.76291124
25	Arterial tortuosity (HP:0005116)	2.72350312
26	White forelock (HP:0002211)	2.65278061
27	Premature rupture of membranes (HP:0001788)	2.65125544
28	Abnormal auditory evoked potentials (HP:0006958)	2.63098178
29	Cortical dysplasia (HP:0002539)	2.54880606
30	Renal Fanconi syndrome (HP:0001994)	2.47296879
31	Conjunctival telangiectasia (HP:0000524)	2.42400865
32	Vitreoretinal degeneration (HP:0000655)	2.41256314
33	Short 4th metacarpal (HP:0010044)	2.39242430
34	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.39242430
35	Spinal muscular atrophy (HP:0007269)	2.33062038
36	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.28481288
37	Patchy hypopigmentation of hair (HP:0011365)	2.27576701
38	Morphological abnormality of the middle ear (HP:0008609)	2.26075994
39	Heterochromia iridis (HP:0001100)	2.24372529
40	Papillary thyroid carcinoma (HP:0002895)	2.22638066
41	Spinal rigidity (HP:0003306)	2.22362281
42	Soft skin (HP:0000977)	2.19674453
43	Abnormal platelet function (HP:0011869)	2.15030371
44	Impaired platelet aggregation (HP:0003540)	2.15030371
45	Atelectasis (HP:0100750)	2.13888874
46	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.05928745
47	Absent epiphyses (HP:0010577)	2.05928745
48	Aortic dissection (HP:0002647)	2.03742992
49	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.02984240
50	Myelomeningocele (HP:0002475)	1.99098027
51	Abnormality of dentin (HP:0010299)	1.96088259
52	Thyroid carcinoma (HP:0002890)	1.95479538
53	Degeneration of anterior horn cells (HP:0002398)	1.94395345
54	Abnormality of the anterior horn cell (HP:0006802)	1.94395345
55	Hepatocellular necrosis (HP:0001404)	1.92514636
56	Increased variability in muscle fiber diameter (HP:0003557)	1.92298570
57	Hypoplasia of the fovea (HP:0007750)	1.91190927
58	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.91190927
59	Decreased central vision (HP:0007663)	1.88897520
60	Medial flaring of the eyebrow (HP:0010747)	1.88404816
61	Abnormality of the fovea (HP:0000493)	1.85958230
62	Increased hepatocellular lipid droplets (HP:0006565)	1.84165296
63	Facial cleft (HP:0002006)	1.80633272
64	Bladder diverticulum (HP:0000015)	1.79791239
65	Partial duplication of thumb phalanx (HP:0009944)	1.79025818
66	Absent frontal sinuses (HP:0002688)	1.77894103
67	Aortic aneurysm (HP:0004942)	1.77428132
68	Partial duplication of the phalanx of hand (HP:0009999)	1.76381592
69	Cutaneous finger syndactyly (HP:0010554)	1.74821801
70	Limb dystonia (HP:0002451)	1.74597852
71	Male infertility (HP:0003251)	1.73857943
72	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.73375760
73	Hyperlipoproteinemia (HP:0010980)	1.72726185
74	Wormian bones (HP:0002645)	1.71283044
75	Neonatal short-limb short stature (HP:0008921)	1.70891600
76	Distal lower limb amyotrophy (HP:0008944)	1.70300584
77	Shallow orbits (HP:0000586)	1.69296894
78	Cervical subluxation (HP:0003308)	1.67931586
79	Abnormal lung lobation (HP:0002101)	1.66974613
80	Exertional dyspnea (HP:0002875)	1.66586579
81	Mitral stenosis (HP:0001718)	1.64406321
82	Aplasia/Hypoplasia of the macula (HP:0008059)	1.62436921
83	Abnormality of skeletal muscle fiber size (HP:0012084)	1.61511549
84	Hypoplasia of the iris (HP:0007676)	1.60092437
85	Bifid tongue (HP:0010297)	1.59323380
86	Ankle contracture (HP:0006466)	1.58251573
87	Hepatic necrosis (HP:0002605)	1.58205991
88	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.56993912
89	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.56993912
90	Bowel diverticulosis (HP:0005222)	1.56893492
91	Bruising susceptibility (HP:0000978)	1.52364469
92	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.50553134
93	Blue irides (HP:0000635)	1.50158634
94	Cutaneous syndactyly (HP:0012725)	1.50032305
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.49351242
96	Upper limb muscle weakness (HP:0003484)	1.47516218
97	Aplasia of the musculature (HP:0100854)	1.46994839
98	Hydroureter (HP:0000072)	1.45755170
99	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.45137666
100	Ulnar bowing (HP:0003031)	1.44946310

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MYLK	4.28254955
2	WEE1	3.49694303
3	CCNB1	3.36701009
4	MAP3K6	2.92880573
5	PNCK	2.87303630
6	TESK1	2.46541337
7	BMX	2.41424365
8	EPHB2	2.37459635
9	PAK4	2.25837275
10	STK3	2.22499448
11	ILK	2.15166488
12	LIMK1	2.03072532
13	PKN2	1.93450549
14	STK24	1.90804587
15	TRIM28	1.90738774
16	CDK8	1.79740035
17	MAP3K12	1.74068477
18	LMTK2	1.62364501
19	EIF2AK1	1.57787199
20	PTK2B	1.51040714
21	TAF1	1.48981115
22	CDK19	1.39821272
23	FLT3	1.39426895
24	NTRK1	1.38950542
25	EPHA2	1.37228230
26	GRK1	1.30081384
27	PDGFRA	1.29334983
28	CDC7	1.29192514
29	TRIB3	1.24844260
30	LATS1	1.24732561
31	PLK3	1.17373831
32	TTN	1.17084010
33	NEK2	1.13237814
34	MINK1	1.12216381
35	SRPK1	1.12106970
36	PAK1	1.11634567
37	ERBB2	1.06169366
38	PTK2	1.02795623
39	SIK1	1.02065398
40	MAPK15	1.01887188
41	BUB1	1.00178250
42	LATS2	0.98166676
43	MST4	0.93800339
44	DAPK3	0.91685050
45	PLK1	0.90325544
46	EPHA4	0.88624556
47	EPHA3	0.88116364
48	PAK2	0.87452064
49	STK38L	0.87156392
50	SIK3	0.79238104
51	MAP3K3	0.78826665
52	ADRBK2	0.75262353
53	RET	0.74727660
54	TTK	0.74572707
55	BRSK1	0.74487006
56	GRK5	0.72152345
57	DDR2	0.71705774
58	AURKB	0.69200447
59	BCR	0.65035314
60	FGFR2	0.60303960
61	MET	0.59324112
62	MAP3K4	0.58729172
63	RPS6KA2	0.58644569
64	MAP3K9	0.56764440
65	RPS6KA4	0.54765177
66	STK39	0.53673242
67	ADRBK1	0.53215291
68	CDK7	0.52496167
69	PDGFRB	0.51059145
70	ERBB4	0.51052085
71	TYRO3	0.49361339
72	ROCK1	0.49244865
73	CDK14	0.49092940
74	CHEK2	0.48565209
75	MAP2K1	0.48126799
76	PRKD1	0.47530117
77	ROCK2	0.46401214
78	PLK2	0.45022356
79	GSK3A	0.43470537
80	UHMK1	0.43388303
81	MAP3K10	0.42170123
82	CDK18	0.39654699
83	VRK1	0.39573691
84	DYRK2	0.39566055
85	ERBB3	0.39333345
86	AURKA	0.37841882
87	CAMK2G	0.36001006
88	MARK3	0.35559467
89	TAOK2	0.35132840
90	ACVR1B	0.35130115
91	CSNK1G2	0.34685630
92	CDK15	0.34656782
93	DYRK1A	0.34519110
94	BRAF	0.34351405
95	CDK9	0.33369847
96	MAP2K2	0.31215234
97	MAP3K7	0.31039145
98	MKNK1	0.30539555
99	CDK11A	0.29460405
100	FGFR1	0.29356011

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ECM-receptor interaction_Homo sapiens_hsa04512	3.62171827
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.74080672
3	Platelet activation_Homo sapiens_hsa04611	2.51920788
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.27136963
5	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.21643023
6	Fatty acid elongation_Homo sapiens_hsa00062	2.21158536
7	Tyrosine metabolism_Homo sapiens_hsa00350	2.07466182
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.02128967
9	Gap junction_Homo sapiens_hsa04540	1.99432330
10	Focal adhesion_Homo sapiens_hsa04510	1.79167382
11	Mismatch repair_Homo sapiens_hsa03430	1.66571176
12	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.65748820
13	Melanogenesis_Homo sapiens_hsa04916	1.58201523
14	Hippo signaling pathway_Homo sapiens_hsa04390	1.56800447
15	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.53331465
16	Glutathione metabolism_Homo sapiens_hsa00480	1.51433271
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.50826230
18	Small cell lung cancer_Homo sapiens_hsa05222	1.48317312
19	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.43669279
20	Huntingtons disease_Homo sapiens_hsa05016	1.42102014
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.41536884
22	Tight junction_Homo sapiens_hsa04530	1.41160778
23	Parkinsons disease_Homo sapiens_hsa05012	1.38870737
24	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.36824943
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36552672
26	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.31532246
27	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.29224257
28	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.28348616
29	Base excision repair_Homo sapiens_hsa03410	1.26734764
30	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.25973201
31	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.25960573
32	Axon guidance_Homo sapiens_hsa04360	1.17379770
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13875654
34	Adherens junction_Homo sapiens_hsa04520	1.06540489
35	Amoebiasis_Homo sapiens_hsa05146	1.06439587
36	Melanoma_Homo sapiens_hsa05218	1.05724279
37	Histidine metabolism_Homo sapiens_hsa00340	1.04510040
38	DNA replication_Homo sapiens_hsa03030	1.04120241
39	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.03597145
40	Cocaine addiction_Homo sapiens_hsa05030	1.03534057
41	Alcoholism_Homo sapiens_hsa05034	1.02637283
42	Endometrial cancer_Homo sapiens_hsa05213	1.00549309
43	Serotonergic synapse_Homo sapiens_hsa04726	1.00074940
44	Pathways in cancer_Homo sapiens_hsa05200	0.99987286
45	Notch signaling pathway_Homo sapiens_hsa04330	0.99251498
46	Alzheimers disease_Homo sapiens_hsa05010	0.98504095
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.95616737
48	Cell cycle_Homo sapiens_hsa04110	0.94714968
49	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91042356
50	Wnt signaling pathway_Homo sapiens_hsa04310	0.89834167
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.88395614
52	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.88062268
53	Proteoglycans in cancer_Homo sapiens_hsa05205	0.87155924
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87011023
55	Rap1 signaling pathway_Homo sapiens_hsa04015	0.86859809
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.85601599
57	Glioma_Homo sapiens_hsa05214	0.81339490
58	Oocyte meiosis_Homo sapiens_hsa04114	0.80335316
59	Prostate cancer_Homo sapiens_hsa05215	0.79269546
60	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.74254152
61	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.67778846
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.67100399
63	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.67033913
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66536987
65	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.63731894
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63727595
67	Cholinergic synapse_Homo sapiens_hsa04725	0.63457853
68	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62503518
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60707115
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60340775
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.59613127
72	Endocytosis_Homo sapiens_hsa04144	0.58729563
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57155048
74	Thyroid cancer_Homo sapiens_hsa05216	0.57076990
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.56766995
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.56216523
77	MicroRNAs in cancer_Homo sapiens_hsa05206	0.56109171
78	Protein export_Homo sapiens_hsa03060	0.55085138
79	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.54895671
80	Estrogen signaling pathway_Homo sapiens_hsa04915	0.54547456
81	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.54317477
82	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.50882309
83	Circadian entrainment_Homo sapiens_hsa04713	0.50030179
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49814452
85	Gastric acid secretion_Homo sapiens_hsa04971	0.48970044
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48289231
87	Morphine addiction_Homo sapiens_hsa05032	0.48161602
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.48008852
89	Amphetamine addiction_Homo sapiens_hsa05031	0.47631819
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.47378867
91	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.47033255
92	Nitrogen metabolism_Homo sapiens_hsa00910	0.45527613
93	Ras signaling pathway_Homo sapiens_hsa04014	0.44624690
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44422582
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41877144
96	Renal cell carcinoma_Homo sapiens_hsa05211	0.40459479
97	Shigellosis_Homo sapiens_hsa05131	0.40155856
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.39536071
99	Long-term depression_Homo sapiens_hsa04730	0.38030893
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.37694499

MEIS3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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