MELTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.90586798
2protein localization to endosome (GO:0036010)4.72145320
3protein retention in ER lumen (GO:0006621)4.70446086
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.60449545
5basement membrane organization (GO:0071711)4.55071466
6COPI coating of Golgi vesicle (GO:0048205)4.45757888
7Golgi transport vesicle coating (GO:0048200)4.45757888
8semaphorin-plexin signaling pathway (GO:0071526)4.25775412
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.19968384
10desmosome organization (GO:0002934)4.02282078
11regulation of early endosome to late endosome transport (GO:2000641)4.00647311
12activation of Rac GTPase activity (GO:0032863)3.92368473
13regulation of apoptotic process involved in morphogenesis (GO:1902337)3.84880808
14melanin biosynthetic process (GO:0042438)3.75588586
15glial cell migration (GO:0008347)3.72735840
16barbed-end actin filament capping (GO:0051016)3.63213457
17cell-substrate junction assembly (GO:0007044)3.62512804
18adhesion of symbiont to host (GO:0044406)3.50714788
19melanin metabolic process (GO:0006582)3.48215171
20apoptotic process involved in morphogenesis (GO:0060561)3.46347620
21skin morphogenesis (GO:0043589)3.43371951
22negative regulation of adherens junction organization (GO:1903392)3.42585269
23negative regulation of focal adhesion assembly (GO:0051895)3.42585269
24negative regulation of cell junction assembly (GO:1901889)3.42585269
25cell adhesion mediated by integrin (GO:0033627)3.41881932
26cell-cell junction maintenance (GO:0045217)3.41457797
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.40335904
28epithelial cell-cell adhesion (GO:0090136)3.34623487
29endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.32459982
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.22818862
31endothelial cell morphogenesis (GO:0001886)3.22234450
32positive regulation of odontogenesis (GO:0042482)3.21389260
33mannose metabolic process (GO:0006013)3.20255561
34NIK/NF-kappaB signaling (GO:0038061)3.20006738
35negative regulation of homotypic cell-cell adhesion (GO:0034111)3.19665314
36positive regulation of astrocyte differentiation (GO:0048711)3.18910616
37regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18570146
38glycosphingolipid catabolic process (GO:0046479)3.14105313
39branching involved in mammary gland duct morphogenesis (GO:0060444)3.08985177
40pinocytosis (GO:0006907)3.08148472
41hypotonic response (GO:0006971)3.06811397
42endothelial cell chemotaxis (GO:0035767)3.04513157
43endocytic recycling (GO:0032456)3.02737953
44low-density lipoprotein particle clearance (GO:0034383)2.99103048
45cytoskeletal anchoring at plasma membrane (GO:0007016)2.97575699
46planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96966101
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96777524
48virion attachment to host cell (GO:0019062)2.95466154
49adhesion of symbiont to host cell (GO:0044650)2.95466154
50membrane protein ectodomain proteolysis (GO:0006509)2.90735971
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.89800015
52positive regulation of Cdc42 GTPase activity (GO:0043089)2.88910365
53negative regulation of viral release from host cell (GO:1902187)2.87001706
54activation of MAPKKK activity (GO:0000185)2.86879794
55regulation of cholesterol homeostasis (GO:2000188)2.85452917
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83809981
57glycolipid catabolic process (GO:0019377)2.78981113
58proline biosynthetic process (GO:0006561)2.77926494
59adherens junction assembly (GO:0034333)2.74500601
60negative regulation of macroautophagy (GO:0016242)2.74201647
61cell volume homeostasis (GO:0006884)2.72957581
62regulation of glucose import in response to insulin stimulus (GO:2001273)2.72251267
63protein maturation by protein folding (GO:0022417)2.71508908
64decidualization (GO:0046697)2.68902893
65focal adhesion assembly (GO:0048041)2.67640852
66cell-substrate adherens junction assembly (GO:0007045)2.67640852
67regulation of integrin activation (GO:0033623)2.64599430
68positive regulation of osteoblast proliferation (GO:0033690)2.61410102
69activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59985141
70diaphragm development (GO:0060539)2.59529634
71modulation by symbiont of host cellular process (GO:0044068)2.59119175
72membrane protein intracellular domain proteolysis (GO:0031293)2.58679433
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57942239
74peptidyl-proline hydroxylation (GO:0019511)2.56425794
75protein hydroxylation (GO:0018126)2.56379744
76nuclear envelope reassembly (GO:0031468)2.56144495
77mitotic nuclear envelope reassembly (GO:0007084)2.56144495
78serine transport (GO:0032329)2.55547158
79secondary metabolite biosynthetic process (GO:0044550)2.54134630
80endodermal cell differentiation (GO:0035987)2.53218110
81cellular copper ion homeostasis (GO:0006878)2.52992238
82positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.52979562
83glucose 6-phosphate metabolic process (GO:0051156)2.52333833
84stress fiber assembly (GO:0043149)2.52299354
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.49380232
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.49169024
87UV protection (GO:0009650)2.49027016
88positive regulation of nuclease activity (GO:0032075)2.48271313
89angiogenesis involved in wound healing (GO:0060055)2.47702409
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.45979985
91renal filtration (GO:0097205)2.44877680
92trophoblast giant cell differentiation (GO:0060707)2.44456749
93response to thyroid hormone (GO:0097066)2.42586409
94hyaluronan catabolic process (GO:0030214)2.42272180
95cell junction maintenance (GO:0034331)2.42231306
96positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.42189267
97intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.40064641
98actin filament depolymerization (GO:0030042)2.37262796
99regulation of vitamin D biosynthetic process (GO:0060556)2.37177511
100membrane raft organization (GO:0031579)2.36321301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.33468670
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.63268131
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.22008605
4ZNF263_19887448_ChIP-Seq_K562_Human2.98146816
5LXR_22292898_ChIP-Seq_THP-1_Human2.88751907
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.64957264
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.45521092
8RACK7_27058665_Chip-Seq_MCF-7_Human2.37910641
9VDR_21846776_ChIP-Seq_THP-1_Human2.37410000
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36498017
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28368836
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07669453
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07657506
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04645441
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03965749
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93974593
17MYC_22102868_ChIP-Seq_BL_Human1.88273346
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85848334
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84117358
20UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.81237712
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72347640
22KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68275345
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.64546236
24ATF3_27146783_Chip-Seq_COLON_Human1.62493938
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60503607
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59294405
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58681106
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57493923
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56578429
30TP53_22127205_ChIP-Seq_IMR90_Human1.56222166
31KDM2B_26808549_Chip-Seq_K562_Human1.54725741
32TCF7_22412390_ChIP-Seq_EML_Mouse1.54172893
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51330208
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.51099722
35KDM2B_26808549_Chip-Seq_DND41_Human1.48415801
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48363583
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45323047
38P68_20966046_ChIP-Seq_HELA_Human1.44534894
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42503213
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40116475
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.38065571
42HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36354778
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35196150
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34972557
45CLOCK_20551151_ChIP-Seq_293T_Human1.34071936
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.29429939
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.26587122
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25674323
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25419814
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.25021556
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24606639
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23775491
53VDR_24763502_ChIP-Seq_THP-1_Human1.22503755
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22368170
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22082685
56SMC4_20622854_ChIP-Seq_HELA_Human1.21758577
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21613297
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.19177166
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18728496
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18337291
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18337291
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17676159
63BCOR_27268052_Chip-Seq_Bcells_Human1.16665364
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14595213
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.13423774
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.13010364
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12368525
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11295334
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11221622
70NCOR1_26117541_ChIP-Seq_K562_Human1.09915704
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08670711
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07576889
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07295625
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07230768
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07183710
76BCL6_27268052_Chip-Seq_Bcells_Human1.06690635
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06525350
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05403864
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05395252
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03103191
81RARA_24833708_ChIP-Seq_LIVER_Mouse1.02657762
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02269002
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02024511
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00851485
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.00581123
86CREB1_26743006_Chip-Seq_LNCaP_Human1.00383815
87RUNX1_27514584_Chip-Seq_MCF-7_Human0.98158874
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97579377
89RARB_24833708_ChIP-Seq_LIVER_Mouse0.97071063
90MAF_26560356_Chip-Seq_TH1_Human0.96197594
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95890536
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95330833
93PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95327323
94TP63_22573176_ChIP-Seq_HFKS_Human0.95004581
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94966239
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94617893
97RXR_22158963_ChIP-Seq_LIVER_Mouse0.94575727
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94379559
99MAF_26560356_Chip-Seq_TH2_Human0.92321069
100CTCF_27219007_Chip-Seq_Bcells_Human0.92213192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.16393674
2MP0005171_absent_coat_pigmentation4.11807043
3MP0002877_abnormal_melanocyte_morpholog3.84553066
4MP0008438_abnormal_cutaneous_collagen3.79242469
5MP0009840_abnormal_foam_cell3.15639378
6MP0005257_abnormal_intraocular_pressure3.09412400
7MP0004858_abnormal_nervous_system3.03121715
8MP0003705_abnormal_hypodermis_morpholog2.97328219
9MP0005451_abnormal_body_composition2.94562545
10MP0010234_abnormal_vibrissa_follicle2.94037613
11MP0004272_abnormal_basement_membrane2.76137481
12MP0005409_darkened_coat_color2.54246430
13MP0003453_abnormal_keratinocyte_physiol2.52532889
14MP0005408_hypopigmentation2.48837833
15MP0003566_abnormal_cell_adhesion2.38210738
16MP0004381_abnormal_hair_follicle2.26570854
17MP0001348_abnormal_lacrimal_gland2.15016069
18MP0003172_abnormal_lysosome_physiology2.07072777
19MP0003091_abnormal_cell_migration1.97104844
20MP0001849_ear_inflammation1.91813381
21MP0005076_abnormal_cell_differentiation1.90956173
22MP0005023_abnormal_wound_healing1.89713466
23MP0002060_abnormal_skin_morphology1.86501367
24MP0008260_abnormal_autophagy1.63674300
25MP0002089_abnormal_postnatal_growth/wei1.59668123
26MP0000678_abnormal_parathyroid_gland1.58863509
27MP0000858_altered_metastatic_potential1.58549008
28MP0000015_abnormal_ear_pigmentation1.57877539
29MP0004510_myositis1.53680916
30MP0005623_abnormal_meninges_morphology1.43802435
31MP0003191_abnormal_cellular_cholesterol1.41806716
32MP0005501_abnormal_skin_physiology1.35853961
33MP0004947_skin_inflammation1.34994740
34MP0002254_reproductive_system_inflammat1.32770737
35MP0000537_abnormal_urethra_morphology1.29081229
36MP0002796_impaired_skin_barrier1.23974139
37MP0002998_abnormal_bone_remodeling1.23353184
38MP0001216_abnormal_epidermal_layer1.23115080
39MP0002075_abnormal_coat/hair_pigmentati1.20705873
40MP0000751_myopathy1.20591379
41MP0004264_abnormal_extraembryonic_tissu1.20295207
42MP0003329_amyloid_beta_deposits1.18940865
43MP0000579_abnormal_nail_morphology1.18046003
44MP0000003_abnormal_adipose_tissue1.17996920
45MP0005075_abnormal_melanosome_morpholog1.16950170
46MP0000371_diluted_coat_color1.11863415
47MP0001186_pigmentation_phenotype1.11455296
48MP0010030_abnormal_orbit_morphology1.08633171
49MP0003634_abnormal_glial_cell1.07856079
50MP0003045_fibrosis1.05763067
51MP0000733_abnormal_muscle_development1.03836953
52MP0002896_abnormal_bone_mineralization1.03442739
53MP0003303_peritoneal_inflammation1.00918274
54MP0000604_amyloidosis0.95006182
55MP0004185_abnormal_adipocyte_glucose0.94794993
56MP0003436_decreased_susceptibility_to0.92362891
57MP0005508_abnormal_skeleton_morphology0.91542533
58MP0005330_cardiomyopathy0.89666700
59MP0003806_abnormal_nucleotide_metabolis0.88106066
60MP0010771_integument_phenotype0.87732749
61MP0000343_altered_response_to0.87094486
62MP0002933_joint_inflammation0.86489806
63MP0003075_altered_response_to0.86314275
64MP0010352_gastrointestinal_tract_polyps0.86225600
65MP0005275_abnormal_skin_tensile0.85897421
66MP0009053_abnormal_anal_canal0.84836491
67MP0005197_abnormal_uvea_morphology0.83687113
68MP0002139_abnormal_hepatobiliary_system0.82978680
69MP0005621_abnormal_cell_physiology0.82152950
70MP0005375_adipose_tissue_phenotype0.80862499
71MP0003950_abnormal_plasma_membrane0.80366205
72MP0009931_abnormal_skin_appearance0.79485190
73MP0000685_abnormal_immune_system0.79212783
74MP0000762_abnormal_tongue_morphology0.77826052
75MP0009278_abnormal_bone_marrow0.77460503
76MP0003300_gastrointestinal_ulcer0.77308544
77MP0000467_abnormal_esophagus_morphology0.76575387
78MP0002098_abnormal_vibrissa_morphology0.76414664
79MP0005670_abnormal_white_adipose0.76291211
80MP0005164_abnormal_response_to0.73732363
81MP0000372_irregular_coat_pigmentation0.73514349
82MP0005360_urolithiasis0.71660007
83MP0000367_abnormal_coat/_hair0.70967166
84MP0003448_altered_tumor_morphology0.70768652
85MP0005666_abnormal_adipose_tissue0.70039135
86MP0000566_synostosis0.67386773
87MP0001873_stomach_inflammation0.67098661
88MP0005165_increased_susceptibility_to0.66584133
89MP0000013_abnormal_adipose_tissue0.66130411
90MP0000377_abnormal_hair_follicle0.65886124
91MP0004233_abnormal_muscle_weight0.64723876
92MP0003795_abnormal_bone_structure0.64290574
93MP0001915_intracranial_hemorrhage0.63992250
94MP0005390_skeleton_phenotype0.63176614
95MP0000920_abnormal_myelination0.62598486
96MP0003123_paternal_imprinting0.62404084
97MP0003279_aneurysm0.62328622
98MP0002113_abnormal_skeleton_development0.61356957
99MP0001243_abnormal_dermal_layer0.59100776
100MP0000747_muscle_weakness0.58980161

Predicted human phenotypes

RankGene SetZ-score
1Upper limb amyotrophy (HP:0009129)4.24527885
2Distal upper limb amyotrophy (HP:0007149)4.24527885
3Cerebral aneurysm (HP:0004944)3.90783624
4J-shaped sella turcica (HP:0002680)3.69729739
5Hand muscle atrophy (HP:0009130)3.60517139
6Premature rupture of membranes (HP:0001788)3.56961552
7Hyperacusis (HP:0010780)3.54737509
8Abnormality of liposaccharide metabolism (HP:0010968)3.52880021
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.52880021
10Abnormality of glycolipid metabolism (HP:0010969)3.52880021
11Vertebral compression fractures (HP:0002953)3.51801678
12Abnormality of the distal phalanges of the toes (HP:0010182)3.37362298
13Distal lower limb amyotrophy (HP:0008944)3.23711028
14Short nail (HP:0001799)3.19652960
15Achilles tendon contracture (HP:0001771)3.14809790
16White forelock (HP:0002211)3.00812112
17Distal lower limb muscle weakness (HP:0009053)2.96083211
18Broad face (HP:0000283)2.93929515
19Atrophic scars (HP:0001075)2.93332986
20Ulnar bowing (HP:0003031)2.92761329
21Dysostosis multiplex (HP:0000943)2.88681105
22Abnormality of the Achilles tendon (HP:0005109)2.83077508
23Axonal loss (HP:0003447)2.72746698
24Nuclear cataract (HP:0100018)2.67201928
25Protrusio acetabuli (HP:0003179)2.66980837
26Increased cerebral lipofuscin (HP:0011813)2.66848173
27Stridor (HP:0010307)2.66792147
28Fragile skin (HP:0001030)2.64120508
29Neurofibrillary tangles (HP:0002185)2.63413291
30Natal tooth (HP:0000695)2.54934583
31Increased connective tissue (HP:0009025)2.54589357
32Patchy hypopigmentation of hair (HP:0011365)2.53200261
33Flat acetabular roof (HP:0003180)2.52495408
34Loss of speech (HP:0002371)2.50093657
35Insomnia (HP:0100785)2.44597173
36Focal segmental glomerulosclerosis (HP:0000097)2.43863450
37Peripheral hypomyelination (HP:0007182)2.41256496
38Cerebral inclusion bodies (HP:0100314)2.40559313
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.35953359
40Alopecia of scalp (HP:0002293)2.33356279
41Elbow flexion contracture (HP:0002987)2.32965420
42Milia (HP:0001056)2.30522152
43Diaphragmatic weakness (HP:0009113)2.30505322
44Paraparesis (HP:0002385)2.29759990
45Myocardial infarction (HP:0001658)2.29206976
46Trismus (HP:0000211)2.21158500
47Osteolytic defects of the hand bones (HP:0009699)2.18240105
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.18240105
49Ocular albinism (HP:0001107)2.13994785
50Supranuclear gaze palsy (HP:0000605)2.13926042
51Deep venous thrombosis (HP:0002625)2.13913236
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11700957
53Abnormality of polysaccharide metabolism (HP:0011012)2.11700957
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11700957
55Upper limb muscle weakness (HP:0003484)2.09310667
56Difficulty climbing stairs (HP:0003551)2.07808391
57Shallow orbits (HP:0000586)2.07608469
58Urinary glycosaminoglycan excretion (HP:0003541)2.06815906
59Mucopolysacchariduria (HP:0008155)2.06815906
60Hypopigmentation of the fundus (HP:0007894)2.05619220
61Glomerulosclerosis (HP:0000096)2.04816807
62Hemorrhage of the eye (HP:0011885)2.04293102
63Onycholysis (HP:0001806)2.03238623
64Interstitial pulmonary disease (HP:0006530)2.02336533
65Spastic paraparesis (HP:0002313)2.00498864
66Lower limb amyotrophy (HP:0007210)1.98479634
67Deformed sella turcica (HP:0002681)1.97316059
68Hypoplasia of the iris (HP:0007676)1.96268568
69Nail dystrophy (HP:0008404)1.95212982
70Small epiphyses (HP:0010585)1.94719259
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94448964
72Bowed forearm bones (HP:0003956)1.92333183
73Bowing of the arm (HP:0006488)1.92333183
74Spinal cord compression (HP:0002176)1.91943206
75Coxa vara (HP:0002812)1.90393407
76Abnormality of the thoracic spine (HP:0100711)1.89650415
77Cervical subluxation (HP:0003308)1.86670639
78Spinal rigidity (HP:0003306)1.86113262
79Pili torti (HP:0003777)1.85266078
80Thin bony cortex (HP:0002753)1.84439480
81Generalized amyotrophy (HP:0003700)1.83870690
82Pathologic fracture (HP:0002756)1.80845737
83Vacuolated lymphocytes (HP:0001922)1.80502391
84Spondylolisthesis (HP:0003302)1.78898306
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77967305
86Advanced eruption of teeth (HP:0006288)1.77295569
87Thoracic kyphosis (HP:0002942)1.77258309
88Selective tooth agenesis (HP:0001592)1.76324256
89Bulbar palsy (HP:0001283)1.75716589
90Long palpebral fissure (HP:0000637)1.74592371
91Flattened epiphyses (HP:0003071)1.74348289
92Obstructive sleep apnea (HP:0002870)1.73297207
93Entropion (HP:0000621)1.72318664
94Mildly elevated creatine phosphokinase (HP:0008180)1.71817938
95Long toe (HP:0010511)1.70942717
96Prolonged neonatal jaundice (HP:0006579)1.69460841
97Heterochromia iridis (HP:0001100)1.69246684
98Bilateral sensorineural hearing impairment (HP:0008619)1.68561090
99Systemic lupus erythematosus (HP:0002725)1.68545051
100Bone pain (HP:0002653)1.67389237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.16293625
2EPHA24.68476123
3LMTK24.04990723
4MST1R4.00854998
5IRAK33.58325237
6TRIB33.18047820
7ERN13.16446749
8SIK12.92095810
9ICK2.69442956
10SMG12.38375133
11PAK42.16527721
12MET1.90751616
13TAOK21.85918074
14PRPF4B1.71750005
15RIPK11.67361740
16MAP3K31.64569286
17PTK21.60222031
18TESK11.59345250
19PDGFRA1.52946247
20ARAF1.49852388
21EPHB11.45637940
22TTN1.45554940
23MAP3K111.39720437
24DDR21.35664270
25CDK121.25096664
26CDC42BPA1.24147283
27EEF2K1.19736911
28PIM21.18325113
29ERBB41.16288463
30SIK21.13603236
31EPHB21.12847529
32TESK21.12480204
33TBK11.04590144
34MOS0.97916741
35MAP2K30.97224542
36MAP3K130.97011912
37LIMK10.95092226
38PTK60.93322363
39SIK30.89032472
40PKN20.88225068
41BRAF0.87524002
42MAP3K60.86470580
43CDK80.81922266
44MAP3K140.81355151
45BMX0.80659302
46MAP3K80.80560248
47PRKD20.80524907
48MTOR0.80447949
49ABL20.80247261
50LATS20.77012201
51NTRK10.76374757
52RPS6KA20.68103825
53MAPK110.66850229
54PDPK10.64540574
55MAP3K10.63559269
56MAP4K10.61066377
57MAP2K60.60576252
58PRKD30.59897397
59FGFR40.59394197
60PRKG20.58916690
61MAP3K90.58765766
62PHKG10.58347998
63PHKG20.58347998
64MAP3K20.55751844
65CDK70.55006185
66DAPK10.54652954
67HIPK20.50875873
68ZAP700.49846449
69MAPKAPK30.48950309
70TAOK10.47167280
71CHUK0.46718389
72NEK20.46483504
73ILK0.46022585
74DAPK30.44888864
75PDGFRB0.43459510
76MUSK0.43126756
77IRAK20.42837204
78MARK20.42480023
79PAK10.39306458
80AURKA0.38672816
81TGFBR20.37833286
82DMPK0.37547700
83CDK40.36332597
84TRPM70.35733818
85MAPKAPK20.35649781
86PAK20.35614473
87PRKCI0.35487839
88STK100.35393834
89MAPK150.34408498
90MELK0.34122221
91MAP3K100.31204984
92GSK3A0.30086471
93IKBKB0.29417182
94MATK0.27723355
95CDK90.27200788
96LRRK20.25439901
97KSR20.25108572
98CDK11A0.24062518
99RPS6KC10.23684331
100RPS6KL10.23684331

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.17108972
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.03921873
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.96839919
4Galactose metabolism_Homo sapiens_hsa000522.43190376
5Lysosome_Homo sapiens_hsa041422.42154095
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.37273434
7Fructose and mannose metabolism_Homo sapiens_hsa000512.25549893
8Bladder cancer_Homo sapiens_hsa052192.07737039
9ECM-receptor interaction_Homo sapiens_hsa045122.04607624
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95668793
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.86485929
12Notch signaling pathway_Homo sapiens_hsa043301.82220307
13Small cell lung cancer_Homo sapiens_hsa052221.77771238
14Prion diseases_Homo sapiens_hsa050201.69571809
15Chronic myeloid leukemia_Homo sapiens_hsa052201.62355259
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.52130139
17Focal adhesion_Homo sapiens_hsa045101.50016628
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47952458
19Pentose phosphate pathway_Homo sapiens_hsa000301.44771829
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36692346
21Sulfur relay system_Homo sapiens_hsa041221.34651582
22TNF signaling pathway_Homo sapiens_hsa046681.34127025
23Vibrio cholerae infection_Homo sapiens_hsa051101.31212623
24N-Glycan biosynthesis_Homo sapiens_hsa005101.29435794
25Apoptosis_Homo sapiens_hsa042101.28874749
26Toxoplasmosis_Homo sapiens_hsa051451.28260878
27Salmonella infection_Homo sapiens_hsa051321.28046110
28Sphingolipid metabolism_Homo sapiens_hsa006001.23394341
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23223338
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22974421
31VEGF signaling pathway_Homo sapiens_hsa043701.16886376
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16162268
33Acute myeloid leukemia_Homo sapiens_hsa052211.15047696
34Pancreatic cancer_Homo sapiens_hsa052121.14667166
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09450337
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.03344508
37Shigellosis_Homo sapiens_hsa051311.02848936
38Proteoglycans in cancer_Homo sapiens_hsa052051.01335923
39Biosynthesis of amino acids_Homo sapiens_hsa012300.97008567
40Amoebiasis_Homo sapiens_hsa051460.96003667
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93606641
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93431114
43Influenza A_Homo sapiens_hsa051640.93254283
44Non-small cell lung cancer_Homo sapiens_hsa052230.89013493
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.86343373
46Pertussis_Homo sapiens_hsa051330.82563872
47Thyroid cancer_Homo sapiens_hsa052160.82444252
48Osteoclast differentiation_Homo sapiens_hsa043800.82306710
49Viral carcinogenesis_Homo sapiens_hsa052030.80259877
50Protein digestion and absorption_Homo sapiens_hsa049740.77771141
51Hepatitis C_Homo sapiens_hsa051600.76549003
52Phenylalanine metabolism_Homo sapiens_hsa003600.75172890
53Vitamin B6 metabolism_Homo sapiens_hsa007500.72092121
54Glioma_Homo sapiens_hsa052140.70797584
55HTLV-I infection_Homo sapiens_hsa051660.70179416
56Insulin resistance_Homo sapiens_hsa049310.70174295
57Hepatitis B_Homo sapiens_hsa051610.69805369
58Adherens junction_Homo sapiens_hsa045200.69472045
59Viral myocarditis_Homo sapiens_hsa054160.67093731
60MicroRNAs in cancer_Homo sapiens_hsa052060.66436260
61Endocytosis_Homo sapiens_hsa041440.65586437
62ErbB signaling pathway_Homo sapiens_hsa040120.64375104
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63695208
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63417993
65Renal cell carcinoma_Homo sapiens_hsa052110.62533210
66GnRH signaling pathway_Homo sapiens_hsa049120.62141811
67Insulin signaling pathway_Homo sapiens_hsa049100.61810603
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.60921473
69Leishmaniasis_Homo sapiens_hsa051400.60866822
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60150547
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59958344
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59745892
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59701934
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.57908204
75B cell receptor signaling pathway_Homo sapiens_hsa046620.57233515
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54345054
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54085659
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54081853
79Phagosome_Homo sapiens_hsa041450.53782006
80Lysine degradation_Homo sapiens_hsa003100.53658087
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53117170
82Herpes simplex infection_Homo sapiens_hsa051680.52171954
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51300354
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50632551
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49684921
86Epstein-Barr virus infection_Homo sapiens_hsa051690.48935433
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.48747850
88p53 signaling pathway_Homo sapiens_hsa041150.48385924
89Tuberculosis_Homo sapiens_hsa051520.47673723
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46652170
91Vitamin digestion and absorption_Homo sapiens_hsa049770.46497919
92Starch and sucrose metabolism_Homo sapiens_hsa005000.46257204
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.45339217
94Tyrosine metabolism_Homo sapiens_hsa003500.44455973
95Endometrial cancer_Homo sapiens_hsa052130.44394025
96Dilated cardiomyopathy_Homo sapiens_hsa054140.42989865
97Complement and coagulation cascades_Homo sapiens_hsa046100.42428607
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41379492
99DNA replication_Homo sapiens_hsa030300.40094246
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37746702

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »