MEMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.24388333
2mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.02786607
3mitochondrial respiratory chain complex I assembly (GO:0032981)5.02786607
4NADH dehydrogenase complex assembly (GO:0010257)5.02786607
5DNA strand elongation involved in DNA replication (GO:0006271)4.53849487
6ribosomal small subunit assembly (GO:0000028)4.50785472
7DNA replication initiation (GO:0006270)4.47693213
8protein complex biogenesis (GO:0070271)4.44231872
9telomere maintenance via semi-conservative replication (GO:0032201)4.34637925
10DNA strand elongation (GO:0022616)4.30700260
11sulfation (GO:0051923)4.21861290
12mitochondrial respiratory chain complex assembly (GO:0033108)4.20584783
13DNA replication checkpoint (GO:0000076)4.15530713
14formation of translation preinitiation complex (GO:0001731)4.14833234
15CENP-A containing nucleosome assembly (GO:0034080)4.10059346
16purine nucleobase biosynthetic process (GO:0009113)4.06843038
17mitotic metaphase plate congression (GO:0007080)4.05568232
18nucleobase biosynthetic process (GO:0046112)4.04697383
19telomere maintenance via recombination (GO:0000722)3.96091576
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.93256530
21chromatin remodeling at centromere (GO:0031055)3.93193934
22protein localization to kinetochore (GO:0034501)3.88166974
23protein polyglutamylation (GO:0018095)3.86394731
24ribosome assembly (GO:0042255)3.85851675
25folic acid-containing compound biosynthetic process (GO:0009396)3.79399638
26maturation of SSU-rRNA (GO:0030490)3.78761941
27water-soluble vitamin biosynthetic process (GO:0042364)3.77444595
28mitotic recombination (GO:0006312)3.69452478
29ribosome biogenesis (GO:0042254)3.68886516
30DNA unwinding involved in DNA replication (GO:0006268)3.68842436
31negative regulation of mast cell activation (GO:0033004)3.67666623
32DNA replication-independent nucleosome organization (GO:0034724)3.67005792
33DNA replication-independent nucleosome assembly (GO:0006336)3.67005792
34protein localization to chromosome, centromeric region (GO:0071459)3.62699823
35somite development (GO:0061053)3.62195958
36cell proliferation in forebrain (GO:0021846)3.59208510
37mitotic nuclear envelope disassembly (GO:0007077)3.59120282
38translational termination (GO:0006415)3.57575294
39viral transcription (GO:0019083)3.57270632
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.56734024
41replication fork processing (GO:0031297)3.56233266
42synapsis (GO:0007129)3.52051052
43IMP biosynthetic process (GO:0006188)3.50962230
44response to pheromone (GO:0019236)3.50925424
45cellular response to ATP (GO:0071318)3.49219582
46attachment of spindle microtubules to kinetochore (GO:0008608)3.49024161
47ribosomal large subunit biogenesis (GO:0042273)3.48155387
48kinetochore organization (GO:0051383)3.47574106
49ribonucleoprotein complex biogenesis (GO:0022613)3.47031030
50behavioral response to nicotine (GO:0035095)3.45942621
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.45146545
52proteasome assembly (GO:0043248)3.43800600
53histone exchange (GO:0043486)3.43544806
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42102505
55metaphase plate congression (GO:0051310)3.38861541
56translational initiation (GO:0006413)3.38039191
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37884417
58rRNA modification (GO:0000154)3.37652473
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.33458538
60isotype switching (GO:0045190)3.33458538
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.33458538
62membrane disassembly (GO:0030397)3.32710919
63nuclear envelope disassembly (GO:0051081)3.32710919
64translational elongation (GO:0006414)3.32607553
65rRNA processing (GO:0006364)3.31345647
66telomere maintenance via telomere lengthening (GO:0010833)3.29948818
67protein K6-linked ubiquitination (GO:0085020)3.29385093
68folic acid metabolic process (GO:0046655)3.28940317
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27643220
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26975668
71regulation of spindle organization (GO:0090224)3.26021591
72IMP metabolic process (GO:0046040)3.25878398
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.25122525
74double-strand break repair via homologous recombination (GO:0000724)3.24416999
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24230379
76DNA replication-dependent nucleosome organization (GO:0034723)3.23808421
77DNA replication-dependent nucleosome assembly (GO:0006335)3.23808421
78regulation of glomerulus development (GO:0090192)3.23686582
79recombinational repair (GO:0000725)3.23242457
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23147265
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22586560
82piRNA metabolic process (GO:0034587)3.22206397
83spliceosomal snRNP assembly (GO:0000387)3.20746578
84rRNA metabolic process (GO:0016072)3.19474888
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19386718
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16749600
87kinetochore assembly (GO:0051382)3.15391780
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12653172
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12653172
90preassembly of GPI anchor in ER membrane (GO:0016254)3.11192253
91G1/S transition of mitotic cell cycle (GO:0000082)3.09460042
92cell cycle G1/S phase transition (GO:0044843)3.09460042
93somatic diversification of immunoglobulins (GO:0016445)3.09273639
94ribosomal small subunit biogenesis (GO:0042274)3.08494931
95cotranslational protein targeting to membrane (GO:0006613)3.06773427
96somatic recombination of immunoglobulin gene segments (GO:0016447)3.06690947
97mitochondrion morphogenesis (GO:0070584)3.06447504
98transcription-coupled nucleotide-excision repair (GO:0006283)3.05616319
99mitotic chromosome condensation (GO:0007076)3.05190784
100protein targeting to ER (GO:0045047)3.05066945
101establishment of chromosome localization (GO:0051303)3.02587086
102magnesium ion transport (GO:0015693)3.01327071
103regulation of mesoderm development (GO:2000380)2.99674736
104pseudouridine synthesis (GO:0001522)2.99325402
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98944504
106regulation of sequestering of triglyceride (GO:0010889)2.97691322
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96082857
108negative regulation of ligase activity (GO:0051352)2.96082857
109endoderm formation (GO:0001706)2.95931733
110protein localization to endoplasmic reticulum (GO:0070972)2.94441042
111deoxyribonucleotide biosynthetic process (GO:0009263)2.92397355
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92143807
113nuclear pore organization (GO:0006999)2.92072404
114translation (GO:0006412)2.91748194
115positive regulation of mitochondrial fission (GO:0090141)2.90595974
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90217028
1177-methylguanosine mRNA capping (GO:0006370)2.90157897
118maturation of 5.8S rRNA (GO:0000460)2.89572757
119kynurenine metabolic process (GO:0070189)2.89268268
120viral mRNA export from host cell nucleus (GO:0046784)2.87913327
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.87781177
122histone-serine phosphorylation (GO:0035404)2.87770801
123tryptophan metabolic process (GO:0006568)2.87640567
124termination of RNA polymerase III transcription (GO:0006386)2.87514467
125transcription elongation from RNA polymerase III promoter (GO:0006385)2.87514467
126indole-containing compound catabolic process (GO:0042436)2.85297952
127indolalkylamine catabolic process (GO:0046218)2.85297952
128tryptophan catabolic process (GO:0006569)2.85297952
129keratinocyte development (GO:0003334)2.85238281
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85162037
131GPI anchor metabolic process (GO:0006505)2.85095480
1327-methylguanosine RNA capping (GO:0009452)2.84415791
133RNA capping (GO:0036260)2.84415791
134DNA methylation involved in gamete generation (GO:0043046)2.83045748
135regulation of DNA endoreduplication (GO:0032875)2.82119804
136male meiosis I (GO:0007141)2.81149200
137rRNA methylation (GO:0031167)2.80111224
138nuclear pore complex assembly (GO:0051292)2.79278228
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78927578
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.78927578
141cellular component biogenesis (GO:0044085)2.78683612
142cellular protein complex disassembly (GO:0043624)2.78087383
143mitotic sister chromatid segregation (GO:0000070)2.78038734
144DNA double-strand break processing (GO:0000729)2.77422497
145translesion synthesis (GO:0019985)2.77239504
146indolalkylamine metabolic process (GO:0006586)2.76931087
147positive regulation of ligase activity (GO:0051351)2.76577179
148viral life cycle (GO:0019058)2.75394100
149negative regulation of systemic arterial blood pressure (GO:0003085)2.75026081
150spindle checkpoint (GO:0031577)2.74216492
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.74151256
152negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74151256
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74151256
154negative regulation of sister chromatid segregation (GO:0033046)2.74151256
155positive regulation of chromosome segregation (GO:0051984)2.73627017
156DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73407291
157prostate gland growth (GO:0060736)2.73337308
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.72945758
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.72945758
160maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70427277
161protein neddylation (GO:0045116)2.66266111
162response to xenobiotic stimulus (GO:0009410)2.64628980
163negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63454921
164ATP synthesis coupled proton transport (GO:0015986)2.61703471
165energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61703471
166response to UV-C (GO:0010225)2.61459661
167tRNA processing (GO:0008033)2.58334352
168respiratory chain complex IV assembly (GO:0008535)2.57431674
169adenosine metabolic process (GO:0046085)2.57344582
170mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56659848
171DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.55373372
172regulation of germinal center formation (GO:0002634)2.53552385
173centriole replication (GO:0007099)2.52699558
174glycerol ether metabolic process (GO:0006662)2.51157197
175protein sumoylation (GO:0016925)2.50297782
176mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50168443
177embryonic epithelial tube formation (GO:0001838)2.49456527
178positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.48494243
179ether metabolic process (GO:0018904)2.47022594
180resolution of meiotic recombination intermediates (GO:0000712)2.46406780
181negative regulation of astrocyte differentiation (GO:0048712)2.45489230
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.45213768
183chaperone-mediated protein transport (GO:0072321)2.44858405
184positive regulation of cardiac muscle cell differentiation (GO:2000727)2.43089847
185regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39069584
186regulation of mitotic spindle checkpoint (GO:1903504)2.39069584
187RNA phosphodiester bond hydrolysis (GO:0090501)2.38916718
188regulation of action potential (GO:0098900)2.38135470
189tRNA modification (GO:0006400)2.37028436
190cytochrome complex assembly (GO:0017004)2.35650034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.62037836
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21011832
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.20767638
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.72426786
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.39773182
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38985570
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37225261
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.08955207
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00735035
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98860676
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.96020403
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86729882
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81332706
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.79342633
15VDR_22108803_ChIP-Seq_LS180_Human2.71318188
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66900838
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63949075
18ZNF274_21170338_ChIP-Seq_K562_Hela2.60041074
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59752280
20GBX2_23144817_ChIP-Seq_PC3_Human2.56562860
21EWS_26573619_Chip-Seq_HEK293_Human2.47270223
22FUS_26573619_Chip-Seq_HEK293_Human2.47255976
23AR_21909140_ChIP-Seq_LNCAP_Human2.37858295
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36793818
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.35376710
26VDR_23849224_ChIP-Seq_CD4+_Human2.34196868
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32204020
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24414988
29IGF1R_20145208_ChIP-Seq_DFB_Human2.23792301
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22412084
31XRN2_22483619_ChIP-Seq_HELA_Human2.20871102
32* DCP1A_22483619_ChIP-Seq_HELA_Human2.15128245
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14176264
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13961260
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11392533
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11104360
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05395142
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03396740
39ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01336789
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01278168
41* GABP_19822575_ChIP-Seq_HepG2_Human1.99434975
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.97045618
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96812957
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.96135120
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94444084
46IRF1_19129219_ChIP-ChIP_H3396_Human1.92269065
47FOXP3_21729870_ChIP-Seq_TREG_Human1.91218882
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89671232
49P300_19829295_ChIP-Seq_ESCs_Human1.85713349
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85709699
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80454087
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79863273
53TAF15_26573619_Chip-Seq_HEK293_Human1.78138845
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74432415
55ER_23166858_ChIP-Seq_MCF-7_Human1.74245193
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74005763
57ELK1_19687146_ChIP-ChIP_HELA_Human1.72780146
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72214987
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.71451632
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71144423
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70163856
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68732220
63TTF2_22483619_ChIP-Seq_HELA_Human1.66535092
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62518971
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62169788
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57662736
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57078711
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51500196
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.50275652
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48907298
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47638833
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46623082
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43915357
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42257113
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41977676
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40764186
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39955523
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38982509
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.36864603
80KDM5A_27292631_Chip-Seq_BREAST_Human1.36526839
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36467595
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36204202
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33421050
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31167556
85* MYC_22102868_ChIP-Seq_BL_Human1.31123029
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30424903
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29969766
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29087418
89CBP_20019798_ChIP-Seq_JUKART_Human1.27833470
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27833470
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.27004520
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.26684489
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24148296
94* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24116150
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24035654
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22291193
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22042849
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.21092715
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19101327
100NANOG_19829295_ChIP-Seq_ESCs_Human1.18622773
101SOX2_19829295_ChIP-Seq_ESCs_Human1.18622773
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17361604
103* CIITA_25753668_ChIP-Seq_RAJI_Human1.16877693
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16346997
105TFEB_21752829_ChIP-Seq_HELA_Human1.15787057
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15710664
107SMAD4_21799915_ChIP-Seq_A2780_Human1.15086403
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14923970
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14505305
110EZH2_22144423_ChIP-Seq_EOC_Human1.14208805
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13459360
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12736570
113* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11077590
114* STAT3_23295773_ChIP-Seq_U87_Human1.10393815
115TP53_22573176_ChIP-Seq_HFKS_Human1.09306401
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08827252
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.08827252
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08259569
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.07792617
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07631640
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07137504
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06695259
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06067079
124* TCF4_23295773_ChIP-Seq_U87_Human1.05333472
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04677039
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04516198
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04478076
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04187078
129P53_22387025_ChIP-Seq_ESCs_Mouse1.03810261
130IRF8_21731497_ChIP-ChIP_J774_Mouse1.03590114
131* SPI1_23547873_ChIP-Seq_NB4_Human1.03396531
132* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03200738
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02626754
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02538304
135AR_25329375_ChIP-Seq_VCAP_Human1.02285694
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.02014521
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.01968445
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.01453173
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00263001
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99926978
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99466558
142BCAT_22108803_ChIP-Seq_LS180_Human0.99136494
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98678733
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.97810225
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97333086
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97319095
147* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96058455
148MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95497262
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94990705
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94496724
151JUN_21703547_ChIP-Seq_K562_Human0.94444548
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94398024
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94261666
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93767696
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92975015
156ELK1_22589737_ChIP-Seq_MCF10A_Human0.90179753
157* VDR_21846776_ChIP-Seq_THP-1_Human0.87876470
158MYC_18940864_ChIP-ChIP_HL60_Human0.86744322
159ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86714675
160CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86512571
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82021191
162TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81615982
163IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80979773
164MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80246093
165CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79647568
166CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78729119
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77392569
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77344868
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75172545
170* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74790043
171ZNF263_19887448_ChIP-Seq_K562_Human0.71776794
172NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70094250
173HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69129392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12958153
2MP0010094_abnormal_chromosome_stability4.00599025
3MP0004957_abnormal_blastocyst_morpholog4.00075049
4MP0003111_abnormal_nucleus_morphology3.79562769
5MP0003077_abnormal_cell_cycle3.47567208
6MP0008057_abnormal_DNA_replication3.18335730
7MP0004145_abnormal_muscle_electrophysio2.98007288
8MP0005646_abnormal_pituitary_gland2.96445143
9MP0003656_abnormal_erythrocyte_physiolo2.91709210
10MP0002837_dystrophic_cardiac_calcinosis2.89281355
11MP0002396_abnormal_hematopoietic_system2.88051796
12MP0006292_abnormal_olfactory_placode2.81440839
13MP0008058_abnormal_DNA_repair2.73932251
14MP0008007_abnormal_cellular_replicative2.72444565
15MP0000569_abnormal_digit_pigmentation2.50951890
16MP0002160_abnormal_reproductive_system2.44796689
17MP0003806_abnormal_nucleotide_metabolis2.43774097
18MP0003123_paternal_imprinting2.31516084
19MP0006054_spinal_hemorrhage2.31179037
20MP0002138_abnormal_hepatobiliary_system2.24669029
21MP0008932_abnormal_embryonic_tissue2.23622694
22MP0004147_increased_porphyrin_level2.20350095
23MP0005397_hematopoietic_system_phenotyp2.16377409
24MP0001545_abnormal_hematopoietic_system2.16377409
25MP0000490_abnormal_crypts_of2.05664737
26MP0005389_reproductive_system_phenotype2.04786739
27MP0003195_calcinosis2.01940595
28MP0009053_abnormal_anal_canal2.00138731
29MP0001730_embryonic_growth_arrest1.98161486
30MP0000350_abnormal_cell_proliferation1.88233144
31MP0003724_increased_susceptibility_to1.86845685
32MP0006072_abnormal_retinal_apoptosis1.85474364
33MP0004134_abnormal_chest_morphology1.85471683
34MP0006035_abnormal_mitochondrial_morpho1.81907621
35MP0005670_abnormal_white_adipose1.78118363
36MP0005174_abnormal_tail_pigmentation1.77742162
37MP0010352_gastrointestinal_tract_polyps1.76812538
38MP0001485_abnormal_pinna_reflex1.75311035
39MP0000049_abnormal_middle_ear1.71294717
40MP0010307_abnormal_tumor_latency1.70976277
41MP0009333_abnormal_splenocyte_physiolog1.70036698
42MP0004885_abnormal_endolymph1.67629399
43MP0004142_abnormal_muscle_tone1.62681922
44MP0000631_abnormal_neuroendocrine_gland1.60027029
45MP0003186_abnormal_redox_activity1.58931000
46MP0000013_abnormal_adipose_tissue1.58867749
47MP0004808_abnormal_hematopoietic_stem1.58468220
48MP0001529_abnormal_vocalization1.57773993
49MP0003786_premature_aging1.56911991
50MP0003718_maternal_effect1.56139688
51MP0008872_abnormal_physiological_respon1.53879322
52MP0000383_abnormal_hair_follicle1.52104252
53MP0000372_irregular_coat_pigmentation1.51095717
54MP0000427_abnormal_hair_cycle1.47130984
55MP0005084_abnormal_gallbladder_morpholo1.47032678
56MP0005075_abnormal_melanosome_morpholog1.45102366
57MP0004130_abnormal_muscle_cell1.40030156
58MP0003937_abnormal_limbs/digits/tail_de1.39989541
59MP0001968_abnormal_touch/_nociception1.39876196
60MP0002019_abnormal_tumor_incidence1.38884929
61MP0002751_abnormal_autonomic_nervous1.38482685
62MP0001697_abnormal_embryo_size1.38478112
63MP0002080_prenatal_lethality1.33484208
64MP0001672_abnormal_embryogenesis/_devel1.31321067
65MP0005380_embryogenesis_phenotype1.31321067
66MP0002132_abnormal_respiratory_system1.28810941
67MP0006036_abnormal_mitochondrial_physio1.27843711
68MP0009697_abnormal_copulation1.26624417
69MP0001919_abnormal_reproductive_system1.26498395
70MP0005551_abnormal_eye_electrophysiolog1.25565330
71MP0003984_embryonic_growth_retardation1.24664983
72MP0001853_heart_inflammation1.24452893
73MP0000313_abnormal_cell_death1.24003571
74MP0005367_renal/urinary_system_phenotyp1.21662578
75MP0000516_abnormal_urinary_system1.21662578
76MP0004185_abnormal_adipocyte_glucose1.21384580
77MP0002282_abnormal_trachea_morphology1.21217704
78MP0002088_abnormal_embryonic_growth/wei1.20504946
79MP0002876_abnormal_thyroid_physiology1.20364085
80MP0002398_abnormal_bone_marrow1.18751513
81MP0003567_abnormal_fetal_cardiomyocyte1.18011820
82MP0001661_extended_life_span1.16727395
83MP0003119_abnormal_digestive_system1.15949745
84MP0003763_abnormal_thymus_physiology1.15873762
85MP0002722_abnormal_immune_system1.13602527
86MP0008877_abnormal_DNA_methylation1.12682155
87MP0000689_abnormal_spleen_morphology1.12373522
88MP0002736_abnormal_nociception_after1.10099319
89MP0009250_abnormal_appendicular_skeleto1.09183789
90MP0002086_abnormal_extraembryonic_tissu1.05977561
91MP0000015_abnormal_ear_pigmentation1.01478566
92MP0009765_abnormal_xenobiotic_induced1.00926493
93MP0002210_abnormal_sex_determination0.99555136
94MP0002277_abnormal_respiratory_mucosa0.99486796
95MP0005253_abnormal_eye_physiology0.98913252
96MP0003787_abnormal_imprinting0.98189852
97MP0002085_abnormal_embryonic_tissue0.96246605
98MP0003890_abnormal_embryonic-extraembry0.95854456
99MP0002429_abnormal_blood_cell0.95570149
100MP0000358_abnormal_cell_content/0.95405046
101MP0008775_abnormal_heart_ventricle0.95180498
102MP0001929_abnormal_gametogenesis0.94929681
103MP0000858_altered_metastatic_potential0.93707107
104MP0000750_abnormal_muscle_regeneration0.93694632
105MP0000703_abnormal_thymus_morphology0.92991113
106MP0010030_abnormal_orbit_morphology0.92245192
107MP0003011_delayed_dark_adaptation0.90804832
108MP0001145_abnormal_male_reproductive0.90195698
109MP0003221_abnormal_cardiomyocyte_apopto0.89565641
110MP0005195_abnormal_posterior_eye0.88207262
111MP0005410_abnormal_fertilization0.87557401
112MP0008789_abnormal_olfactory_epithelium0.86374716
113MP0001986_abnormal_taste_sensitivity0.85386049
114MP0000653_abnormal_sex_gland0.84065710
115MP0000647_abnormal_sebaceous_gland0.81983327
116MP0003705_abnormal_hypodermis_morpholog0.81900250
117MP0004197_abnormal_fetal_growth/weight/0.81325534
118MP0000613_abnormal_salivary_gland0.80420772
119MP0008995_early_reproductive_senescence0.79969378
120MP0002735_abnormal_chemical_nociception0.79781557
121MP0010678_abnormal_skin_adnexa0.77373313
122MP0002102_abnormal_ear_morphology0.77151951
123MP0005408_hypopigmentation0.76460593
124MP0003315_abnormal_perineum_morphology0.76264188
125MP0000465_gastrointestinal_hemorrhage0.75772715
126MP0001293_anophthalmia0.75567850
127MP0002272_abnormal_nervous_system0.75462329
128MP0001119_abnormal_female_reproductive0.75200305
129MP0002084_abnormal_developmental_patter0.74808262
130MP0002177_abnormal_outer_ear0.74486201
131MP0002653_abnormal_ependyma_morphology0.74451132
132MP0005671_abnormal_response_to0.73942992
133MP0000716_abnormal_immune_system0.73786575
134MP0001243_abnormal_dermal_layer0.73134414
135MP0008438_abnormal_cutaneous_collagen0.72083659
136MP0009785_altered_susceptibility_to0.71424066
137MP0003938_abnormal_ear_development0.70201912
138MP0000537_abnormal_urethra_morphology0.69794417
139MP0003936_abnormal_reproductive_system0.69368954
140MP0000343_altered_response_to0.69312135
141MP0001542_abnormal_bone_strength0.68433247
142MP0002006_tumorigenesis0.68149287
143MP0001835_abnormal_antigen_presentation0.67643704
144MP0001764_abnormal_homeostasis0.67313735
145MP0001915_intracranial_hemorrhage0.66913172
146MP0002938_white_spotting0.66666582
147MP0000598_abnormal_liver_morphology0.66638953
148MP0002166_altered_tumor_susceptibility0.66082454
149MP0005023_abnormal_wound_healing0.64501557
150MP0002095_abnormal_skin_pigmentation0.62445482
151MP0002405_respiratory_system_inflammati0.62297817
152MP0005384_cellular_phenotype0.61946362
153MP0005621_abnormal_cell_physiology0.60375720
154MP0003646_muscle_fatigue0.60081034
155MP0000477_abnormal_intestine_morphology0.59866768
156MP0009931_abnormal_skin_appearance0.59560863
157MP0005501_abnormal_skin_physiology0.58875882
158MP0000685_abnormal_immune_system0.58588433
159MP0003436_decreased_susceptibility_to0.56674819
160MP0002452_abnormal_antigen_presenting0.56673308
161MP0005266_abnormal_metabolism0.56659219
162MP0004215_abnormal_myocardial_fiber0.56557420
163MP0005275_abnormal_skin_tensile0.56018316
164MP0002420_abnormal_adaptive_immunity0.55751500
165MP0001800_abnormal_humoral_immune0.55395855
166MP0005464_abnormal_platelet_physiology0.55304313
167MP0003943_abnormal_hepatobiliary_system0.55187210
168MP0005636_abnormal_mineral_homeostasis0.54951102
169MP0001819_abnormal_immune_cell0.54864677

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.51149082
2Abnormality of cells of the erythroid lineage (HP:0012130)5.34341208
3Birth length less than 3rd percentile (HP:0003561)5.33557123
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.23778802
5Aplastic anemia (HP:0001915)3.95094541
6Reticulocytopenia (HP:0001896)3.82597837
7Oral leukoplakia (HP:0002745)3.57066120
8Short 1st metacarpal (HP:0010034)3.40937114
9Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.40937114
10Stenosis of the external auditory canal (HP:0000402)3.39221094
11Breast hypoplasia (HP:0003187)3.35088340
12Abnormality of the proximal phalanges of the hand (HP:0009834)3.22518962
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21583349
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21583349
15Pallor (HP:0000980)3.16829180
16Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.13322095
17Pancreatic cysts (HP:0001737)3.08073426
18Acute necrotizing encephalopathy (HP:0006965)3.00319024
19Methylmalonic acidemia (HP:0002912)2.92492573
20Macrocytic anemia (HP:0001972)2.91182891
21Rough bone trabeculation (HP:0100670)2.89360461
22Abnormality of the 1st metacarpal (HP:0010009)2.88133030
23Pendular nystagmus (HP:0012043)2.86969538
24Abnormality of the anterior horn cell (HP:0006802)2.86698816
25Degeneration of anterior horn cells (HP:0002398)2.86698816
26Type 2 muscle fiber atrophy (HP:0003554)2.85107588
27Pancreatic fibrosis (HP:0100732)2.84863998
28Abnormality of the phalanges of the 5th finger (HP:0004213)2.82093626
29Patellar aplasia (HP:0006443)2.79632728
30Selective tooth agenesis (HP:0001592)2.78709690
31Muscle fiber atrophy (HP:0100295)2.77293153
32True hermaphroditism (HP:0010459)2.75145779
33Microretrognathia (HP:0000308)2.73046872
343-Methylglutaconic aciduria (HP:0003535)2.70058486
35Petechiae (HP:0000967)2.69503372
36Poor head control (HP:0002421)2.69025442
37Conjunctival hamartoma (HP:0100780)2.68359634
38Poikilocytosis (HP:0004447)2.64836282
39Aplasia/Hypoplasia of the patella (HP:0006498)2.61607489
40Progressive macrocephaly (HP:0004481)2.60317614
41Abnormality of the nasal septum (HP:0000419)2.60142817
42Nephronophthisis (HP:0000090)2.59982098
43Abolished electroretinogram (ERG) (HP:0000550)2.59647756
44Thrombocytosis (HP:0001894)2.54424288
45Hypoplasia of the uterus (HP:0000013)2.51869943
46Abnormality of midbrain morphology (HP:0002418)2.51816250
47Molar tooth sign on MRI (HP:0002419)2.51816250
48Abnormality of reticulocytes (HP:0004312)2.49901076
49Abnormality of DNA repair (HP:0003254)2.49751802
50Entropion (HP:0000621)2.49151420
51Aplasia/Hypoplasia of the hallux (HP:0008362)2.48825798
52Secondary amenorrhea (HP:0000869)2.48085639
53Acute encephalopathy (HP:0006846)2.47630353
54Abnormality of the preputium (HP:0100587)2.45727011
55Impulsivity (HP:0100710)2.45595400
56Short hallux (HP:0010109)2.44124325
57Cerebral hypomyelination (HP:0006808)2.43983356
58Abnormal spermatogenesis (HP:0008669)2.42945731
59Abnormality of alanine metabolism (HP:0010916)2.42799876
60Hyperalaninemia (HP:0003348)2.42799876
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42799876
62Chromsome breakage (HP:0040012)2.42461672
63Carpal bone hypoplasia (HP:0001498)2.40262209
64Increased serum lactate (HP:0002151)2.40104449
65Trismus (HP:0000211)2.39959582
66Abnormality of chromosome stability (HP:0003220)2.38430507
67Congenital stationary night blindness (HP:0007642)2.35768077
68Premature graying of hair (HP:0002216)2.34467671
69Ectopic kidney (HP:0000086)2.32833257
70Abnormality of the renal collecting system (HP:0004742)2.29951689
71Myelodysplasia (HP:0002863)2.29763015
72Aplasia/hypoplasia of the uterus (HP:0008684)2.29682884
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.29167131
74Sparse eyelashes (HP:0000653)2.28051252
75Multiple enchondromatosis (HP:0005701)2.27797094
76Short middle phalanx of the 5th finger (HP:0004220)2.25683768
77Genetic anticipation (HP:0003743)2.25225909
78Renal cortical cysts (HP:0000803)2.24999783
79Premature ovarian failure (HP:0008209)2.23065002
80Hepatocellular necrosis (HP:0001404)2.22636819
81Slender long bone (HP:0003100)2.22492207
82Small hand (HP:0200055)2.21161115
83Symphalangism affecting the phalanges of the hand (HP:0009773)2.20788425
84Increased intramyocellular lipid droplets (HP:0012240)2.18090160
85Fused cervical vertebrae (HP:0002949)2.17553144
86Hamartoma of the eye (HP:0010568)2.16921527
87Methylmalonic aciduria (HP:0012120)2.16656526
88Furrowed tongue (HP:0000221)2.15696488
89Tongue fasciculations (HP:0001308)2.14618428
90Progressive muscle weakness (HP:0003323)2.13809928
91Postnatal microcephaly (HP:0005484)2.13783568
92Ureteral duplication (HP:0000073)2.13303650
93Decreased subcutaneous fat (HP:0001002)2.13096840
94Increased CSF lactate (HP:0002490)2.12827558
95Hepatic necrosis (HP:0002605)2.12456670
96Pancytopenia (HP:0001876)2.11574040
97Abnormality of the renal cortex (HP:0011035)2.11532547
98Acanthocytosis (HP:0001927)2.10118731
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07479519
100Meningioma (HP:0002858)2.06056327
101Abnormality of the renal medulla (HP:0100957)2.06000543
102Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.05202666
103Colon cancer (HP:0003003)2.04692192
104Short tibia (HP:0005736)2.03422593
105Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03374386
106Abnormal trabecular bone morphology (HP:0100671)2.02167413
107Muscle fibrillation (HP:0010546)2.01217837
108Increased corneal curvature (HP:0100692)2.00088421
109Keratoconus (HP:0000563)2.00088421
110Short phalanx of the thumb (HP:0009660)1.99955230
111Sclerocornea (HP:0000647)1.99860389
112Meckel diverticulum (HP:0002245)1.99536960
11311 pairs of ribs (HP:0000878)1.99346583
114IgM deficiency (HP:0002850)1.98317029
115Respiratory difficulties (HP:0002880)1.97406015
116Increased hepatocellular lipid droplets (HP:0006565)1.97396495
117Bone marrow hypocellularity (HP:0005528)1.97254831
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96133310
119Increased muscle lipid content (HP:0009058)1.96085890
120Pustule (HP:0200039)1.94823396
121Reduced antithrombin III activity (HP:0001976)1.93823371
122Small intestinal stenosis (HP:0012848)1.92634211
123Duodenal stenosis (HP:0100867)1.92634211
124Abnormality of the middle phalanges of the toes (HP:0010183)1.92590005
125Calcaneovalgus deformity (HP:0001848)1.92557578
126Horseshoe kidney (HP:0000085)1.92487929
127Squamous cell carcinoma (HP:0002860)1.92061844
128Chorioretinal atrophy (HP:0000533)1.91896335
129Erythroderma (HP:0001019)1.91366912
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90809554
131Lipid accumulation in hepatocytes (HP:0006561)1.90734639
132Abnormality of methionine metabolism (HP:0010901)1.90378738
133Cerebral edema (HP:0002181)1.90272652
134Thyroiditis (HP:0100646)1.89725535
135Absent phalangeal crease (HP:0006109)1.89019238
136Clubbing of toes (HP:0100760)1.89000263
137Prostate neoplasm (HP:0100787)1.88048410
138Abnormality of the carotid arteries (HP:0005344)1.87920576
139Abnormal mitochondria in muscle tissue (HP:0008316)1.87410993
140Humeroradial synostosis (HP:0003041)1.86625192
141Synostosis involving the elbow (HP:0003938)1.86625192
142IgG deficiency (HP:0004315)1.86268047
143Nausea (HP:0002018)1.86175059
144Lactic acidosis (HP:0003128)1.85883627
145Type I transferrin isoform profile (HP:0003642)1.85140937
146Exertional dyspnea (HP:0002875)1.84821054
147Abnormality of the ileum (HP:0001549)1.84198009
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.83776449
149Irregular epiphyses (HP:0010582)1.83564602
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82956359
151Atresia of the external auditory canal (HP:0000413)1.82521552
152Cleft eyelid (HP:0000625)1.82244957
153Neoplasm of the pancreas (HP:0002894)1.81780938
154Deformed tarsal bones (HP:0008119)1.80878226
155Sloping forehead (HP:0000340)1.80832253
156Homocystinuria (HP:0002156)1.80666519
157Abnormality of homocysteine metabolism (HP:0010919)1.80666519
158Morphological abnormality of the middle ear (HP:0008609)1.80293181
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80169432
160Abnormal protein N-linked glycosylation (HP:0012347)1.80169432
161Abnormal protein glycosylation (HP:0012346)1.80169432
162Abnormal glycosylation (HP:0012345)1.80169432
163Long nose (HP:0003189)1.79881509
164Mitochondrial inheritance (HP:0001427)1.79581040
165Asplenia (HP:0001746)1.79206226
166Megaloblastic anemia (HP:0001889)1.78377671
167Severe combined immunodeficiency (HP:0004430)1.78200371
168Pulmonary fibrosis (HP:0002206)1.77664216
169Absent thumb (HP:0009777)1.77106335
170Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76783845
171Aplasia/Hypoplasia of the uvula (HP:0010293)1.75972834
172Increased serum ferritin (HP:0003281)1.75894077
173Abnormal rod and cone electroretinograms (HP:0008323)1.75665699
174Abnormal finger flexion creases (HP:0006143)1.75290211
175Congenital, generalized hypertrichosis (HP:0004540)1.75284007
176Reticulocytosis (HP:0001923)1.75259148
177Abnormality of the duodenum (HP:0002246)1.75114780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.10862903
2NME23.96314616
3WEE13.89404312
4FRK3.83273773
5BUB13.77768091
6CDC73.17696628
7ACVR1B3.16576677
8GRK12.97502929
9NEK12.81846349
10NEK22.69889739
11TAOK32.53154923
12EIF2AK32.50856093
13ADRBK22.49423999
14BRSK22.48634024
15MAP3K122.47925021
16RPS6KA42.34348571
17MST42.30456105
18BMPR1B2.27605742
19CCNB12.06398446
20DYRK32.04535345
21STK162.03676817
22MAP4K21.96930651
23PIM21.95213384
24WNK31.95040912
25PLK41.89530609
26PINK11.88351705
27TESK21.85392731
28SRPK11.75369043
29VRK11.71465300
30PLK11.66649407
31TTK1.63473564
32AURKB1.58039664
33TRIM281.56493489
34BRSK11.53565827
35SCYL21.51649697
36PBK1.51555440
37TXK1.50808860
38MKNK11.46144336
39PLK21.44741263
40MAPK131.39170125
41MAP3K81.32062331
42CDK71.31342850
43OBSCN1.30709750
44TSSK61.27699394
45CHEK21.26265748
46ATR1.24555318
47PLK31.23375616
48STK101.19353992
49TAF11.17861676
50ERBB31.16954899
51PDK31.15683258
52PDK41.15683258
53GRK71.14894478
54KDR1.14260322
55IKBKB1.13822988
56TGFBR11.11728045
57VRK21.11277941
58INSRR1.10916339
59CDK41.10002268
60CSNK1G21.08283719
61STK41.06460971
62ZAK1.05534536
63TESK11.04636064
64RPS6KB21.03821153
65MAP3K111.03183630
66STK391.01108705
67OXSR10.98908431
68WNK40.96102991
69AURKA0.95261491
70CDK80.93150428
71FLT30.93133342
72STK30.93051521
73MKNK20.92807445
74PIM10.92274189
75CSNK1G10.92028341
76MAP2K30.91601002
77DYRK20.89536561
78TNIK0.88201914
79EIF2AK20.86171039
80PIK3CG0.85807913
81PASK0.84010874
82CSNK1A1L0.83249430
83MAP3K30.82230549
84CASK0.82148911
85LRRK20.81164670
86BRAF0.81102093
87CHEK10.80535978
88TLK10.78998090
89MAP2K10.75341947
90EEF2K0.73721693
91BMPR20.73519164
92MUSK0.72525132
93CAMKK20.71478829
94CDK90.70116499
95ADRBK10.69958477
96TEC0.69221839
97PHKG10.68463927
98PHKG20.68463927
99PRKCE0.67323640
100STK240.65585072
101NEK90.64962825
102ABL20.64379594
103PAK40.61042629
104CDK60.60239745
105KIT0.60176530
106CDK190.59700360
107CSNK2A10.59282934
108TAOK20.59093169
109BCKDK0.58844822
110MAPKAPK30.58777498
111JAK30.58513825
112BCR0.58142249
113ITK0.56231346
114RPS6KA50.55421529
115MAP3K40.54800960
116SYK0.54394553
117ILK0.54335056
118MAP3K50.53975069
119CSNK2A20.53578977
120MAP4K10.52319788
121ATM0.52051363
122MAP2K40.50466827
123TBK10.48815177
124MAP3K100.47928306
125ZAP700.47732098
126PDK20.47634112
127IGF1R0.46176522
128DAPK10.46094178
129PTK2B0.44668455
130PAK10.44344891
131MAP2K60.42844325
132CDK20.42791155
133PIK3CA0.42156970
134ABL10.41527381
135TRIB30.39666816
136CSNK1A10.38233882
137MELK0.37120420
138MARK30.36939222
139PRKCQ0.36402280
140STK38L0.33774149
141TIE10.33720408
142BTK0.32853751
143PKN20.32150952
144TTN0.31619807
145RAF10.31035170
146CDK10.30754084
147LIMK10.29045789
148CSNK1G30.23807278
149MAPKAPK20.23677679
150TAOK10.23384764
151NME10.23374859
152LYN0.22988615
153PRKCI0.22320751
154MOS0.18211132
155NUAK10.17809712

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77344240
2Mismatch repair_Homo sapiens_hsa034303.49150726
3Proteasome_Homo sapiens_hsa030503.48877716
4Ribosome_Homo sapiens_hsa030103.45262555
5RNA polymerase_Homo sapiens_hsa030203.39371561
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36824548
7Base excision repair_Homo sapiens_hsa034102.76619080
8RNA transport_Homo sapiens_hsa030132.76419912
9Pyrimidine metabolism_Homo sapiens_hsa002402.73511060
10Cell cycle_Homo sapiens_hsa041102.71304809
11Spliceosome_Homo sapiens_hsa030402.68383655
12Nucleotide excision repair_Homo sapiens_hsa034202.65802612
13Sulfur metabolism_Homo sapiens_hsa009202.62683188
14Homologous recombination_Homo sapiens_hsa034402.57785476
15Asthma_Homo sapiens_hsa053102.38185225
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.29150665
17One carbon pool by folate_Homo sapiens_hsa006702.24215841
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91736219
19p53 signaling pathway_Homo sapiens_hsa041151.84305930
20Vitamin B6 metabolism_Homo sapiens_hsa007501.81246369
21Basal transcription factors_Homo sapiens_hsa030221.80415399
22Non-homologous end-joining_Homo sapiens_hsa034501.73662190
23RNA degradation_Homo sapiens_hsa030181.66053401
24Fanconi anemia pathway_Homo sapiens_hsa034601.64573152
25Folate biosynthesis_Homo sapiens_hsa007901.62021390
26Alzheimers disease_Homo sapiens_hsa050101.57105804
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54931947
28Purine metabolism_Homo sapiens_hsa002301.53275367
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49501486
30Graft-versus-host disease_Homo sapiens_hsa053321.47348618
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38252714
32Systemic lupus erythematosus_Homo sapiens_hsa053221.30885510
33Protein export_Homo sapiens_hsa030601.30505939
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26770042
35Allograft rejection_Homo sapiens_hsa053301.24164183
36Regulation of autophagy_Homo sapiens_hsa041401.22235186
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.20689118
38Autoimmune thyroid disease_Homo sapiens_hsa053201.17624309
39Pentose phosphate pathway_Homo sapiens_hsa000301.15641417
40Selenocompound metabolism_Homo sapiens_hsa004501.11849047
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10631262
42Cardiac muscle contraction_Homo sapiens_hsa042601.09049278
43Sulfur relay system_Homo sapiens_hsa041221.08447462
44mRNA surveillance pathway_Homo sapiens_hsa030151.07436091
45Type I diabetes mellitus_Homo sapiens_hsa049401.04868926
46Nitrogen metabolism_Homo sapiens_hsa009101.04687565
47Epstein-Barr virus infection_Homo sapiens_hsa051691.04072804
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.02814583
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.01076465
50Biosynthesis of amino acids_Homo sapiens_hsa012300.94451653
51Antigen processing and presentation_Homo sapiens_hsa046120.94385924
52Herpes simplex infection_Homo sapiens_hsa051680.93626250
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92741873
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91394683
55Nicotine addiction_Homo sapiens_hsa050330.87701235
56Viral carcinogenesis_Homo sapiens_hsa052030.86242897
57Chemical carcinogenesis_Homo sapiens_hsa052040.84549578
58Taste transduction_Homo sapiens_hsa047420.84497623
59Rheumatoid arthritis_Homo sapiens_hsa053230.84095534
60Glutathione metabolism_Homo sapiens_hsa004800.84024682
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83741981
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83731834
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82139682
64Tryptophan metabolism_Homo sapiens_hsa003800.81083389
65Legionellosis_Homo sapiens_hsa051340.80103801
66Huntingtons disease_Homo sapiens_hsa050160.73741367
67Carbon metabolism_Homo sapiens_hsa012000.73101912
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71310231
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67627419
70Thyroid cancer_Homo sapiens_hsa052160.66525740
71N-Glycan biosynthesis_Homo sapiens_hsa005100.65072594
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64997992
73Oocyte meiosis_Homo sapiens_hsa041140.64781462
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.64116566
75Parkinsons disease_Homo sapiens_hsa050120.63674524
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62282369
77Butanoate metabolism_Homo sapiens_hsa006500.61996223
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59832971
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58722645
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58605923
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56992430
82Small cell lung cancer_Homo sapiens_hsa052220.56025702
83Morphine addiction_Homo sapiens_hsa050320.55917632
84Hematopoietic cell lineage_Homo sapiens_hsa046400.55814349
85Collecting duct acid secretion_Homo sapiens_hsa049660.55344878
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55015269
87Retinol metabolism_Homo sapiens_hsa008300.53976273
88HTLV-I infection_Homo sapiens_hsa051660.53603687
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53526542
90Olfactory transduction_Homo sapiens_hsa047400.52024677
91Glycerolipid metabolism_Homo sapiens_hsa005610.51589819
92Measles_Homo sapiens_hsa051620.51331361
93Steroid biosynthesis_Homo sapiens_hsa001000.50043111
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48634830
95Melanoma_Homo sapiens_hsa052180.47407187
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47215689
97Apoptosis_Homo sapiens_hsa042100.46959145
98Caffeine metabolism_Homo sapiens_hsa002320.45133091
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44940675
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44357962
101Metabolic pathways_Homo sapiens_hsa011000.42979416
102Phototransduction_Homo sapiens_hsa047440.42725610
103Shigellosis_Homo sapiens_hsa051310.41416254
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40184200
105Ether lipid metabolism_Homo sapiens_hsa005650.39531419
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39428464
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38806526
108Oxidative phosphorylation_Homo sapiens_hsa001900.38218983
109Fatty acid elongation_Homo sapiens_hsa000620.37097181
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36852135
111Hepatitis B_Homo sapiens_hsa051610.36664279
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36570695
113Pyruvate metabolism_Homo sapiens_hsa006200.35817641
114Dorso-ventral axis formation_Homo sapiens_hsa043200.35180767
115Malaria_Homo sapiens_hsa051440.32575952
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30264708
117Serotonergic synapse_Homo sapiens_hsa047260.30174909
118Starch and sucrose metabolism_Homo sapiens_hsa005000.30058853
119MicroRNAs in cancer_Homo sapiens_hsa052060.28557766
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.27365275
121Primary immunodeficiency_Homo sapiens_hsa053400.26246627
122Arachidonic acid metabolism_Homo sapiens_hsa005900.25802060
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.24120640
124TGF-beta signaling pathway_Homo sapiens_hsa043500.23846497
125Alcoholism_Homo sapiens_hsa050340.23752135
126Bladder cancer_Homo sapiens_hsa052190.23343512
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23104267
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21576157
129Influenza A_Homo sapiens_hsa051640.21364756
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19217316
131Viral myocarditis_Homo sapiens_hsa054160.18504202
132HIF-1 signaling pathway_Homo sapiens_hsa040660.18123241
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.18017506
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16921369
135Chronic myeloid leukemia_Homo sapiens_hsa052200.15956435
136Arginine and proline metabolism_Homo sapiens_hsa003300.15285486
137Linoleic acid metabolism_Homo sapiens_hsa005910.15213068
138Renin-angiotensin system_Homo sapiens_hsa046140.13740700
139Galactose metabolism_Homo sapiens_hsa000520.13021243
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12786664
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12181857
142Leishmaniasis_Homo sapiens_hsa051400.10349221
143Propanoate metabolism_Homo sapiens_hsa006400.09644508
144Peroxisome_Homo sapiens_hsa041460.09182937

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