

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cytidine deamination (GO:0009972) | 7.67477730 |
| 2 | cytidine metabolic process (GO:0046087) | 7.67477730 |
| 3 | cytidine catabolic process (GO:0006216) | 7.67477730 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 7.12112479 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.99360293 |
| 6 | DNA deamination (GO:0045006) | 6.77590956 |
| 7 | motile cilium assembly (GO:0044458) | 5.45910546 |
| 8 | proteasome assembly (GO:0043248) | 5.22907174 |
| 9 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.19648429 |
| 10 | chaperone-mediated protein transport (GO:0072321) | 5.15229017 |
| 11 | fatty acid elongation (GO:0030497) | 5.01334570 |
| 12 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.79816393 |
| 13 | protein K6-linked ubiquitination (GO:0085020) | 4.67817369 |
| 14 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.37785955 |
| 15 | ATP synthesis coupled proton transport (GO:0015986) | 4.34780143 |
| 16 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.34780143 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.31514730 |
| 18 | protein neddylation (GO:0045116) | 4.18667251 |
| 19 | pseudouridine synthesis (GO:0001522) | 4.18103772 |
| 20 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.06689058 |
| 21 | negative regulation of ligase activity (GO:0051352) | 4.06689058 |
| 22 | positive regulation of interleukin-8 secretion (GO:2000484) | 4.05313171 |
| 23 | respiratory electron transport chain (GO:0022904) | 4.01550120 |
| 24 | termination of RNA polymerase III transcription (GO:0006386) | 3.97642797 |
| 25 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.97642797 |
| 26 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.94560127 |
| 27 | electron transport chain (GO:0022900) | 3.94151338 |
| 28 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.93404261 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.93203243 |
| 30 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.78000241 |
| 31 | centriole assembly (GO:0098534) | 3.77457656 |
| 32 | regulation of mitochondrial translation (GO:0070129) | 3.62604936 |
| 33 | eosinophil chemotaxis (GO:0048245) | 3.60052402 |
| 34 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.51528258 |
| 35 | signal peptide processing (GO:0006465) | 3.49201379 |
| 36 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.46782706 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.41237563 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.41237563 |
| 39 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.41016645 |
| 40 | regulation of retinoic acid receptor signaling pathway (GO:0048385) | 3.36628534 |
| 41 | monocyte chemotaxis (GO:0002548) | 3.36526261 |
| 42 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 3.35227765 |
| 43 | protein complex biogenesis (GO:0070271) | 3.34789317 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.33206606 |
| 45 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.33206606 |
| 46 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.33206606 |
| 47 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.32942028 |
| 48 | replicative senescence (GO:0090399) | 3.32864051 |
| 49 | positive regulation of ligase activity (GO:0051351) | 3.29541716 |
| 50 | protein deneddylation (GO:0000338) | 3.27547584 |
| 51 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27026019 |
| 52 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27026019 |
| 53 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.20352495 |
| 54 | intestinal epithelial cell development (GO:0060576) | 3.20236216 |
| 55 | eosinophil migration (GO:0072677) | 3.20161931 |
| 56 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.17580661 |
| 57 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.16910804 |
| 58 | regulation of ligase activity (GO:0051340) | 3.15111709 |
| 59 | histone mRNA metabolic process (GO:0008334) | 3.15059592 |
| 60 | negative regulation of T cell differentiation in thymus (GO:0033085) | 3.13213167 |
| 61 | protein targeting to mitochondrion (GO:0006626) | 3.09834468 |
| 62 | protein localization to mitochondrion (GO:0070585) | 3.06306242 |
| 63 | intracellular protein transmembrane import (GO:0044743) | 3.04730409 |
| 64 | negative regulation of B cell proliferation (GO:0030889) | 3.04703021 |
| 65 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 3.02884156 |
| 66 | regulation of cellular amine metabolic process (GO:0033238) | 3.01367355 |
| 67 | protein localization to kinetochore (GO:0034501) | 3.00908047 |
| 68 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.00855472 |
| 69 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.00750742 |
| 70 | establishment of protein localization to mitochondrion (GO:0072655) | 2.99115881 |
| 71 | inner mitochondrial membrane organization (GO:0007007) | 2.98265105 |
| 72 | CENP-A containing nucleosome assembly (GO:0034080) | 2.97583444 |
| 73 | positive regulation of actin filament depolymerization (GO:0030836) | 2.97512220 |
| 74 | chromatin remodeling at centromere (GO:0031055) | 2.96417698 |
| 75 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.93981134 |
| 76 | DNA double-strand break processing (GO:0000729) | 2.93972848 |
| 77 | rRNA modification (GO:0000154) | 2.88820678 |
| 78 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.85865422 |
| 79 | negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804) | 2.82808446 |
| 80 | negative regulation of protein ubiquitination (GO:0031397) | 2.82263250 |
| 81 | positive regulation of cell cycle arrest (GO:0071158) | 2.81751829 |
| 82 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.80955907 |
| 83 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.80665341 |
| 84 | postreplication repair (GO:0006301) | 2.78085303 |
| 85 | mitochondrial DNA replication (GO:0006264) | 2.77484324 |
| 86 | DNA dealkylation (GO:0035510) | 2.76473170 |
| 87 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.73836349 |
| 88 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.72308406 |
| 89 | maturation of SSU-rRNA (GO:0030490) | 2.71839625 |
| 90 | mitotic sister chromatid segregation (GO:0000070) | 2.70237891 |
| 91 | NADH dehydrogenase complex assembly (GO:0010257) | 2.69475318 |
| 92 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.69475318 |
| 93 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.69475318 |
| 94 | heterochromatin organization (GO:0070828) | 2.69091636 |
| 95 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.64748197 |
| 96 | regulation of protein sumoylation (GO:0033233) | 2.62543481 |
| 97 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.59358907 |
| 98 | spliceosomal snRNP assembly (GO:0000387) | 2.59133756 |
| 99 | peptidyl-histidine modification (GO:0018202) | 2.58703980 |
| 100 | sequestering of actin monomers (GO:0042989) | 2.58687599 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 5.26798500 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.93950466 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.53433765 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.00138068 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.91773295 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.73244031 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.53976468 |
| 8 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.93792321 |
| 9 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.90317609 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.82156863 |
| 11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.80302964 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.70903218 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59212946 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.51428488 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.48367747 |
| 16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.42225717 |
| 17 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.31111329 |
| 18 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.24936964 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.13556769 |
| 20 | EWS_26573619_Chip-Seq_HEK293_Human | 2.01074851 |
| 21 | FUS_26573619_Chip-Seq_HEK293_Human | 1.99816804 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.97624099 |
| 23 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.96816648 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.91898130 |
| 25 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.90288337 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.87191556 |
| 27 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.82032813 |
| 28 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.81685895 |
| 29 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.81251871 |
| 30 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.77298888 |
| 31 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.74487201 |
| 32 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.56148350 |
| 33 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.55201152 |
| 34 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.54707978 |
| 35 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.54555459 |
| 36 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.52912138 |
| 37 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.51208608 |
| 38 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.50779366 |
| 39 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.50757402 |
| 40 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.49090433 |
| 41 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.48852335 |
| 42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.48681434 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.48300034 |
| 44 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.44669229 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.44061245 |
| 46 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.43730948 |
| 47 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.36519540 |
| 48 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.35866412 |
| 49 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.35782153 |
| 50 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.35364239 |
| 51 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.31373773 |
| 52 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.31222410 |
| 53 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.28927831 |
| 54 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.28568928 |
| 55 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.25354695 |
| 56 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.23386686 |
| 57 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.23084209 |
| 58 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.23084209 |
| 59 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.23084209 |
| 60 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.20680551 |
| 61 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.20342052 |
| 62 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.19031450 |
| 63 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.18365612 |
| 64 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.16934958 |
| 65 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.13846675 |
| 66 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.12864294 |
| 67 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.11513924 |
| 68 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.09158693 |
| 69 | GATA1_22025678_ChIP-Seq_K562_Human | 1.08572709 |
| 70 | VDR_22108803_ChIP-Seq_LS180_Human | 1.08380341 |
| 71 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.08344041 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08328902 |
| 73 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.07833853 |
| 74 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.06317600 |
| 75 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.05742852 |
| 76 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.05075282 |
| 77 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.03083835 |
| 78 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.02150969 |
| 79 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.01696489 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99085130 |
| 81 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.98247144 |
| 82 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.97094725 |
| 83 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.96747232 |
| 84 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.96489188 |
| 85 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.95948207 |
| 86 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.93623335 |
| 87 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.92107811 |
| 88 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.89536766 |
| 89 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.88121181 |
| 90 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.86889192 |
| 91 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.86375370 |
| 92 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.86027745 |
| 93 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.85206486 |
| 94 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.83174874 |
| 95 | P300_19829295_ChIP-Seq_ESCs_Human | 0.82016433 |
| 96 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.81999217 |
| 97 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.81786502 |
| 98 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.81604731 |
| 99 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.80128754 |
| 100 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.79356608 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 3.84885333 |
| 2 | MP0009379_abnormal_foot_pigmentation | 3.25299381 |
| 3 | MP0005646_abnormal_pituitary_gland | 3.11822327 |
| 4 | MP0001529_abnormal_vocalization | 2.98689887 |
| 5 | MP0001188_hyperpigmentation | 2.97837962 |
| 6 | MP0003786_premature_aging | 2.84488352 |
| 7 | MP0005075_abnormal_melanosome_morpholog | 2.79479921 |
| 8 | MP0010307_abnormal_tumor_latency | 2.78759147 |
| 9 | MP0002877_abnormal_melanocyte_morpholog | 2.75046764 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.72642784 |
| 11 | MP0000566_synostosis | 2.67899542 |
| 12 | MP0003111_abnormal_nucleus_morphology | 2.66202498 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.62834704 |
| 14 | MP0002102_abnormal_ear_morphology | 2.15378931 |
| 15 | MP0004957_abnormal_blastocyst_morpholog | 2.13136123 |
| 16 | MP0000647_abnormal_sebaceous_gland | 1.98455623 |
| 17 | MP0001919_abnormal_reproductive_system | 1.97911388 |
| 18 | MP0003806_abnormal_nucleotide_metabolis | 1.97011402 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.96594229 |
| 20 | MP0009697_abnormal_copulation | 1.94122045 |
| 21 | MP0000372_irregular_coat_pigmentation | 1.93455273 |
| 22 | MP0000427_abnormal_hair_cycle | 1.92174487 |
| 23 | MP0008058_abnormal_DNA_repair | 1.91784648 |
| 24 | MP0005408_hypopigmentation | 1.82573738 |
| 25 | MP0005187_abnormal_penis_morphology | 1.82215802 |
| 26 | MP0002090_abnormal_vision | 1.76083152 |
| 27 | MP0006292_abnormal_olfactory_placode | 1.75826618 |
| 28 | MP0003077_abnormal_cell_cycle | 1.75547292 |
| 29 | MP0005389_reproductive_system_phenotype | 1.72392104 |
| 30 | MP0009333_abnormal_splenocyte_physiolog | 1.63439633 |
| 31 | MP0006054_spinal_hemorrhage | 1.57684557 |
| 32 | MP0005623_abnormal_meninges_morphology | 1.56588347 |
| 33 | MP0005423_abnormal_somatic_nervous | 1.56185977 |
| 34 | MP0001905_abnormal_dopamine_level | 1.51128765 |
| 35 | MP0003693_abnormal_embryo_hatching | 1.50260601 |
| 36 | MP0002160_abnormal_reproductive_system | 1.48139057 |
| 37 | MP0004381_abnormal_hair_follicle | 1.45109890 |
| 38 | MP0006036_abnormal_mitochondrial_physio | 1.35964789 |
| 39 | MP0002095_abnormal_skin_pigmentation | 1.34776193 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.34467828 |
| 41 | MP0003186_abnormal_redox_activity | 1.32865669 |
| 42 | MP0003221_abnormal_cardiomyocyte_apopto | 1.26940981 |
| 43 | MP0001984_abnormal_olfaction | 1.26225652 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.26059874 |
| 45 | MP0002163_abnormal_gland_morphology | 1.25183814 |
| 46 | MP0001764_abnormal_homeostasis | 1.25085091 |
| 47 | MP0006082_CNS_inflammation | 1.24146314 |
| 48 | MP0010234_abnormal_vibrissa_follicle | 1.23063651 |
| 49 | MP0005671_abnormal_response_to | 1.20938234 |
| 50 | MP0001542_abnormal_bone_strength | 1.17439749 |
| 51 | MP0010386_abnormal_urinary_bladder | 1.16718167 |
| 52 | MP0002277_abnormal_respiratory_mucosa | 1.16343944 |
| 53 | MP0008873_increased_physiological_sensi | 1.12959832 |
| 54 | MP0002796_impaired_skin_barrier | 1.10971176 |
| 55 | MP0003937_abnormal_limbs/digits/tail_de | 1.10833363 |
| 56 | MP0002210_abnormal_sex_determination | 1.09931761 |
| 57 | MP0006072_abnormal_retinal_apoptosis | 1.07919389 |
| 58 | MP0001186_pigmentation_phenotype | 1.02626757 |
| 59 | MP0002736_abnormal_nociception_after | 1.00536554 |
| 60 | MP0000350_abnormal_cell_proliferation | 1.00111253 |
| 61 | MP0000613_abnormal_salivary_gland | 0.98542919 |
| 62 | MP0005501_abnormal_skin_physiology | 0.98228083 |
| 63 | MP0002168_other_aberrant_phenotype | 0.93103094 |
| 64 | MP0003195_calcinosis | 0.91809213 |
| 65 | MP0000639_abnormal_adrenal_gland | 0.90650843 |
| 66 | MP0002938_white_spotting | 0.89581317 |
| 67 | MP0000653_abnormal_sex_gland | 0.88841205 |
| 68 | MP0003646_muscle_fatigue | 0.87835486 |
| 69 | MP0002148_abnormal_hypersensitivity_rea | 0.87562144 |
| 70 | MP0001881_abnormal_mammary_gland | 0.86646039 |
| 71 | MP0001293_anophthalmia | 0.85794210 |
| 72 | MP0001145_abnormal_male_reproductive | 0.85163865 |
| 73 | MP0005395_other_phenotype | 0.84493713 |
| 74 | MP0001968_abnormal_touch/_nociception | 0.83982809 |
| 75 | MP0008875_abnormal_xenobiotic_pharmacok | 0.83250233 |
| 76 | MP0005647_abnormal_sex_gland | 0.81196080 |
| 77 | MP0003941_abnormal_skin_development | 0.81024858 |
| 78 | MP0005165_increased_susceptibility_to | 0.79676965 |
| 79 | MP0004924_abnormal_behavior | 0.79436472 |
| 80 | MP0005386_behavior/neurological_phenoty | 0.79436472 |
| 81 | MP0004142_abnormal_muscle_tone | 0.79041694 |
| 82 | MP0008932_abnormal_embryonic_tissue | 0.78712087 |
| 83 | MP0003718_maternal_effect | 0.78345141 |
| 84 | MP0000358_abnormal_cell_content/ | 0.75544039 |
| 85 | MP0002138_abnormal_hepatobiliary_system | 0.75288702 |
| 86 | MP0002006_tumorigenesis | 0.75010789 |
| 87 | MP0005360_urolithiasis | 0.73999627 |
| 88 | MP0003045_fibrosis | 0.72348030 |
| 89 | MP0001853_heart_inflammation | 0.72060896 |
| 90 | MP0005253_abnormal_eye_physiology | 0.70486302 |
| 91 | MP0001835_abnormal_antigen_presentation | 0.68228792 |
| 92 | MP0001119_abnormal_female_reproductive | 0.67915804 |
| 93 | MP0001502_abnormal_circadian_rhythm | 0.66375388 |
| 94 | MP0000627_abnormal_mammary_gland | 0.65852054 |
| 95 | MP0009763_increased_sensitivity_to | 0.64027571 |
| 96 | MP0002751_abnormal_autonomic_nervous | 0.63486900 |
| 97 | MP0001929_abnormal_gametogenesis | 0.63046098 |
| 98 | MP0008770_decreased_survivor_rate | 0.62725628 |
| 99 | MP0004147_increased_porphyrin_level | 0.62342190 |
| 100 | MP0000631_abnormal_neuroendocrine_gland | 0.62036139 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Aplastic anemia (HP:0001915) | 5.97999279 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.41349121 |
| 3 | Acute encephalopathy (HP:0006846) | 4.10188411 |
| 4 | Increased serum pyruvate (HP:0003542) | 4.08383355 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.02699074 |
| 6 | Renal Fanconi syndrome (HP:0001994) | 3.95879106 |
| 7 | Oral leukoplakia (HP:0002745) | 3.77619691 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.66589539 |
| 9 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.60705324 |
| 10 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.60705324 |
| 11 | Abnormality of glycolysis (HP:0004366) | 3.55800177 |
| 12 | Congenital, generalized hypertrichosis (HP:0004540) | 3.48198837 |
| 13 | Progressive macrocephaly (HP:0004481) | 3.43611757 |
| 14 | Cerebral edema (HP:0002181) | 3.42993476 |
| 15 | Increased hepatocellular lipid droplets (HP:0006565) | 3.41304462 |
| 16 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.36469420 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.35055497 |
| 18 | Increased CSF lactate (HP:0002490) | 3.34659318 |
| 19 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.28802138 |
| 20 | Meckel diverticulum (HP:0002245) | 3.20012714 |
| 21 | Abnormality of chromosome stability (HP:0003220) | 3.12113969 |
| 22 | Abnormality of the preputium (HP:0100587) | 3.03982778 |
| 23 | Hepatic necrosis (HP:0002605) | 2.99685885 |
| 24 | Abnormality of the ileum (HP:0001549) | 2.91807297 |
| 25 | T lymphocytopenia (HP:0005403) | 2.90650163 |
| 26 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.89578229 |
| 27 | Short tibia (HP:0005736) | 2.83877697 |
| 28 | Chromsome breakage (HP:0040012) | 2.83084189 |
| 29 | Hypothermia (HP:0002045) | 2.76191133 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 2.69380366 |
| 31 | Microvesicular hepatic steatosis (HP:0001414) | 2.67710912 |
| 32 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.66467906 |
| 33 | Hyperphosphaturia (HP:0003109) | 2.61561009 |
| 34 | Microglossia (HP:0000171) | 2.61101222 |
| 35 | Lipid accumulation in hepatocytes (HP:0006561) | 2.59060475 |
| 36 | Exertional dyspnea (HP:0002875) | 2.55452584 |
| 37 | Abnormality of T cell number (HP:0011839) | 2.54215309 |
| 38 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.51250896 |
| 39 | Sparse eyelashes (HP:0000653) | 2.49474203 |
| 40 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.48723192 |
| 41 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.47217954 |
| 42 | Abnormality of alanine metabolism (HP:0010916) | 2.47217954 |
| 43 | Hyperalaninemia (HP:0003348) | 2.47217954 |
| 44 | Small intestinal stenosis (HP:0012848) | 2.45045884 |
| 45 | Duodenal stenosis (HP:0100867) | 2.45045884 |
| 46 | Abnormality of placental membranes (HP:0011409) | 2.42691292 |
| 47 | Amniotic constriction ring (HP:0009775) | 2.42691292 |
| 48 | Clubbing of toes (HP:0100760) | 2.40505461 |
| 49 | Septate vagina (HP:0001153) | 2.38928292 |
| 50 | Abnormality of renal resorption (HP:0011038) | 2.36983380 |
| 51 | Nasolacrimal duct obstruction (HP:0000579) | 2.31882599 |
| 52 | Degeneration of anterior horn cells (HP:0002398) | 2.23198854 |
| 53 | Abnormality of the anterior horn cell (HP:0006802) | 2.23198854 |
| 54 | Carpal bone hypoplasia (HP:0001498) | 2.22551867 |
| 55 | Increased intramyocellular lipid droplets (HP:0012240) | 2.21690762 |
| 56 | Abnormal tarsal ossification (HP:0008369) | 2.21403844 |
| 57 | Multiple enchondromatosis (HP:0005701) | 2.21198917 |
| 58 | Acute lymphatic leukemia (HP:0006721) | 2.20406956 |
| 59 | Type I transferrin isoform profile (HP:0003642) | 2.19914172 |
| 60 | Pancytopenia (HP:0001876) | 2.16816308 |
| 61 | Triphalangeal thumb (HP:0001199) | 2.15968037 |
| 62 | Lactic acidosis (HP:0003128) | 2.15897638 |
| 63 | Myelodysplasia (HP:0002863) | 2.11367596 |
| 64 | Prostate neoplasm (HP:0100787) | 2.08740739 |
| 65 | Exercise intolerance (HP:0003546) | 2.07266944 |
| 66 | Cutaneous melanoma (HP:0012056) | 2.06867709 |
| 67 | Delayed epiphyseal ossification (HP:0002663) | 2.06117125 |
| 68 | Generalized aminoaciduria (HP:0002909) | 2.05262916 |
| 69 | Bone marrow hypocellularity (HP:0005528) | 2.04963961 |
| 70 | Increased serum lactate (HP:0002151) | 2.04641399 |
| 71 | Respiratory failure (HP:0002878) | 2.02674564 |
| 72 | Sclerocornea (HP:0000647) | 2.00764549 |
| 73 | Severe combined immunodeficiency (HP:0004430) | 1.99638658 |
| 74 | Abnormality of the duodenum (HP:0002246) | 1.97918837 |
| 75 | Microretrognathia (HP:0000308) | 1.96525624 |
| 76 | Rough bone trabeculation (HP:0100670) | 1.94832744 |
| 77 | Bifid tongue (HP:0010297) | 1.94209329 |
| 78 | Abnormal trabecular bone morphology (HP:0100671) | 1.92161737 |
| 79 | Abnormal urine phosphate concentration (HP:0012599) | 1.90658604 |
| 80 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.87918190 |
| 81 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.87918190 |
| 82 | Abnormal albumin level (HP:0012116) | 1.87717708 |
| 83 | Hypoalbuminemia (HP:0003073) | 1.87717708 |
| 84 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.87611227 |
| 85 | Optic disc pallor (HP:0000543) | 1.85811353 |
| 86 | Combined immunodeficiency (HP:0005387) | 1.85645610 |
| 87 | Thyroiditis (HP:0100646) | 1.83951194 |
| 88 | Papillary thyroid carcinoma (HP:0002895) | 1.83933717 |
| 89 | Lethargy (HP:0001254) | 1.83195489 |
| 90 | IgG deficiency (HP:0004315) | 1.80876974 |
| 91 | Methylmalonic acidemia (HP:0002912) | 1.80864315 |
| 92 | Choanal atresia (HP:0000453) | 1.80247095 |
| 93 | Testicular atrophy (HP:0000029) | 1.79261257 |
| 94 | Medial flaring of the eyebrow (HP:0010747) | 1.77889499 |
| 95 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.77531699 |
| 96 | Absent radius (HP:0003974) | 1.76120928 |
| 97 | Unsteady gait (HP:0002317) | 1.75922399 |
| 98 | Humeroradial synostosis (HP:0003041) | 1.75755897 |
| 99 | Synostosis involving the elbow (HP:0003938) | 1.75755897 |
| 100 | Abnormality of midbrain morphology (HP:0002418) | 1.72080682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.51429708 |
| 2 | NEK1 | 3.91112207 |
| 3 | MAP3K12 | 3.08510582 |
| 4 | BCKDK | 2.93828370 |
| 5 | BMPR1B | 2.82588090 |
| 6 | TESK2 | 2.82198691 |
| 7 | ERBB3 | 2.78421250 |
| 8 | MAP4K2 | 2.78120564 |
| 9 | EIF2AK3 | 2.58263624 |
| 10 | VRK2 | 2.55293055 |
| 11 | TAF1 | 2.51347570 |
| 12 | SRPK1 | 2.44208632 |
| 13 | TXK | 2.31589972 |
| 14 | PNCK | 2.30129919 |
| 15 | TESK1 | 2.14249925 |
| 16 | VRK1 | 2.10625868 |
| 17 | TNIK | 2.10475400 |
| 18 | TNK2 | 1.95131181 |
| 19 | NUAK1 | 1.83297077 |
| 20 | PBK | 1.82404491 |
| 21 | WEE1 | 1.78578760 |
| 22 | AKT3 | 1.76784333 |
| 23 | LIMK1 | 1.72028057 |
| 24 | KDR | 1.63751148 |
| 25 | ACVR1B | 1.57721299 |
| 26 | MYLK | 1.56248462 |
| 27 | TAOK3 | 1.55072148 |
| 28 | MAP3K13 | 1.55048197 |
| 29 | MKNK2 | 1.44109893 |
| 30 | ERBB4 | 1.41294527 |
| 31 | MAPKAPK3 | 1.34144334 |
| 32 | MST4 | 1.24814762 |
| 33 | TGFBR1 | 1.15690670 |
| 34 | AURKA | 1.13415680 |
| 35 | DAPK1 | 1.08657724 |
| 36 | ARAF | 1.08153101 |
| 37 | CDK8 | 1.03643153 |
| 38 | NME1 | 1.03284046 |
| 39 | CDC7 | 0.99999247 |
| 40 | MAP2K7 | 0.97093934 |
| 41 | DYRK2 | 0.95340852 |
| 42 | GRK1 | 0.94858131 |
| 43 | TTK | 0.92079570 |
| 44 | TRIM28 | 0.91818882 |
| 45 | PIK3CA | 0.91198292 |
| 46 | PAK4 | 0.90962970 |
| 47 | AURKB | 0.90441137 |
| 48 | LATS1 | 0.89786853 |
| 49 | CCNB1 | 0.89148058 |
| 50 | MAP3K9 | 0.85617544 |
| 51 | PLK4 | 0.84628775 |
| 52 | PRKD3 | 0.72690460 |
| 53 | ADRBK2 | 0.70902487 |
| 54 | SCYL2 | 0.69367427 |
| 55 | GRK5 | 0.68569790 |
| 56 | MOS | 0.67081470 |
| 57 | PLK3 | 0.66316075 |
| 58 | CHEK2 | 0.63944341 |
| 59 | ATR | 0.63408296 |
| 60 | MELK | 0.63375455 |
| 61 | DYRK3 | 0.61684812 |
| 62 | CDK7 | 0.60693312 |
| 63 | NTRK3 | 0.60453743 |
| 64 | PLK1 | 0.59619926 |
| 65 | PLK2 | 0.59369787 |
| 66 | ZAK | 0.56828768 |
| 67 | RPS6KA5 | 0.54438067 |
| 68 | EPHA2 | 0.54370555 |
| 69 | TLK1 | 0.54248676 |
| 70 | RPS6KA4 | 0.51526848 |
| 71 | NTRK2 | 0.50889239 |
| 72 | ILK | 0.49796678 |
| 73 | DAPK3 | 0.48612958 |
| 74 | CSNK1A1L | 0.48273746 |
| 75 | PDK2 | 0.48021955 |
| 76 | STK16 | 0.45670269 |
| 77 | MKNK1 | 0.45495041 |
| 78 | TYRO3 | 0.45299763 |
| 79 | BMPR2 | 0.42849169 |
| 80 | MAPK13 | 0.42457880 |
| 81 | BRAF | 0.41635319 |
| 82 | CSNK2A1 | 0.38837507 |
| 83 | CSNK1G3 | 0.38132341 |
| 84 | BRSK2 | 0.35928233 |
| 85 | MINK1 | 0.35637750 |
| 86 | NME2 | 0.35619355 |
| 87 | CLK1 | 0.35594935 |
| 88 | FGFR1 | 0.34168053 |
| 89 | CSNK1G1 | 0.33264363 |
| 90 | ABL2 | 0.31971834 |
| 91 | TSSK6 | 0.30884652 |
| 92 | BRD4 | 0.27794311 |
| 93 | CSNK1A1 | 0.26258855 |
| 94 | PINK1 | 0.25358591 |
| 95 | PASK | 0.25041001 |
| 96 | CSNK2A2 | 0.24549026 |
| 97 | CAMK2A | 0.23447285 |
| 98 | RAF1 | 0.22230686 |
| 99 | EIF2AK1 | 0.22164634 |
| 100 | NEK2 | 0.21440779 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.47205862 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.71783815 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.43849250 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.32952091 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.85710384 |
| 6 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.63633532 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.49228679 |
| 8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.41182506 |
| 9 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.30962801 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.26484454 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.25875464 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 2.25384058 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.04379495 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.99530398 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.94028587 |
| 16 | Spliceosome_Homo sapiens_hsa03040 | 1.77443889 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.64566767 |
| 18 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.62746678 |
| 19 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.58944853 |
| 20 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.58371712 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.58182357 |
| 22 | Alcoholism_Homo sapiens_hsa05034 | 1.57450540 |
| 23 | Mismatch repair_Homo sapiens_hsa03430 | 1.51843534 |
| 24 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.50132690 |
| 25 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47569472 |
| 26 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.40315498 |
| 27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.36757891 |
| 28 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.33068105 |
| 29 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.32909213 |
| 30 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.29131417 |
| 31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.24767947 |
| 32 | Basal transcription factors_Homo sapiens_hsa03022 | 1.22802826 |
| 33 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.20896549 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.15632271 |
| 35 | Cell cycle_Homo sapiens_hsa04110 | 1.09467554 |
| 36 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.05233541 |
| 37 | Allograft rejection_Homo sapiens_hsa05330 | 1.02591378 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.00950968 |
| 39 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.99045116 |
| 40 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.98257493 |
| 41 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.93271853 |
| 42 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.92061375 |
| 43 | Purine metabolism_Homo sapiens_hsa00230 | 0.88033996 |
| 44 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.84212782 |
| 45 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.84198423 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.83893886 |
| 47 | RNA degradation_Homo sapiens_hsa03018 | 0.81677953 |
| 48 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.80688990 |
| 49 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.80656061 |
| 50 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.79536970 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.76939669 |
| 52 | Olfactory transduction_Homo sapiens_hsa04740 | 0.75740301 |
| 53 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.71068049 |
| 54 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.70164788 |
| 55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.69895868 |
| 56 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.69265804 |
| 57 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.68161614 |
| 58 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.66459014 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.64964676 |
| 60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.63922056 |
| 61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.63168278 |
| 62 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.61528529 |
| 63 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.59617437 |
| 64 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.59286809 |
| 65 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59185645 |
| 66 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.58803838 |
| 67 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.56882678 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55515623 |
| 69 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.55179153 |
| 70 | Viral myocarditis_Homo sapiens_hsa05416 | 0.55170737 |
| 71 | Base excision repair_Homo sapiens_hsa03410 | 0.53325529 |
| 72 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.52124399 |
| 73 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.51763497 |
| 74 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.51330459 |
| 75 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.48615581 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.46815070 |
| 77 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.46236196 |
| 78 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.45812003 |
| 79 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44341266 |
| 80 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.43176276 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42769265 |
| 82 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42665735 |
| 83 | Asthma_Homo sapiens_hsa05310 | 0.42495358 |
| 84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.40524011 |
| 85 | Salmonella infection_Homo sapiens_hsa05132 | 0.39503582 |
| 86 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.38169687 |
| 87 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37960780 |
| 88 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.34269850 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34228416 |
| 90 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.33851702 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.33172349 |
| 92 | Taste transduction_Homo sapiens_hsa04742 | 0.31780770 |
| 93 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.31599959 |
| 94 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.29961056 |
| 95 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.28757381 |
| 96 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.26394865 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.26216927 |
| 98 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23431900 |
| 99 | Carbon metabolism_Homo sapiens_hsa01200 | 0.22412691 |
| 100 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.22082548 |

