MEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.61678980
2proline biosynthetic process (GO:0006561)4.82372692
3folic acid-containing compound biosynthetic process (GO:0009396)4.62778694
4regulation of mammary gland epithelial cell proliferation (GO:0033599)4.53478172
5DNA strand elongation involved in DNA replication (GO:0006271)4.36660440
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.26448865
7protein localization to kinetochore (GO:0034501)4.18030717
8regulation of translational fidelity (GO:0006450)4.13125150
9DNA strand elongation (GO:0022616)4.07474480
10ribosomal small subunit assembly (GO:0000028)4.03192940
11negative regulation of RNA splicing (GO:0033119)3.99933076
12peptidyl-arginine omega-N-methylation (GO:0035247)3.96424490
13Golgi transport vesicle coating (GO:0048200)3.94722595
14COPI coating of Golgi vesicle (GO:0048205)3.94722595
15formation of translation preinitiation complex (GO:0001731)3.88645372
16peptidyl-lysine dimethylation (GO:0018027)3.86379787
17viral transcription (GO:0019083)3.80861354
18mitotic nuclear envelope disassembly (GO:0007077)3.77822785
19DNA replication initiation (GO:0006270)3.77405181
20mitotic chromosome condensation (GO:0007076)3.75889430
21IMP biosynthetic process (GO:0006188)3.74379149
22glucocorticoid receptor signaling pathway (GO:0042921)3.72144263
23protein retention in ER lumen (GO:0006621)3.71858259
24pre-miRNA processing (GO:0031054)3.70821704
25apoptotic process involved in morphogenesis (GO:0060561)3.70109041
26translational termination (GO:0006415)3.70027131
27nucleosome disassembly (GO:0006337)3.69206185
28protein-DNA complex disassembly (GO:0032986)3.69206185
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62462166
30translational elongation (GO:0006414)3.62146960
31nuclear envelope disassembly (GO:0051081)3.58750813
32membrane disassembly (GO:0030397)3.58750813
33dosage compensation (GO:0007549)3.57782374
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.57715584
35negative regulation of histone methylation (GO:0031061)3.56799107
36telomere maintenance via semi-conservative replication (GO:0032201)3.56772234
37regulation of translational termination (GO:0006449)3.47810194
38DNA duplex unwinding (GO:0032508)3.44733794
39heterochromatin organization (GO:0070828)3.44441525
40peptidyl-arginine N-methylation (GO:0035246)3.43807909
41peptidyl-arginine methylation (GO:0018216)3.43807909
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43613343
43mitotic G1 DNA damage checkpoint (GO:0031571)3.41588041
44DNA geometric change (GO:0032392)3.40540541
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39922013
46activation of Rac GTPase activity (GO:0032863)3.37878200
47proline metabolic process (GO:0006560)3.35678098
48histone arginine methylation (GO:0034969)3.34417117
49translational initiation (GO:0006413)3.33168896
50DNA topological change (GO:0006265)3.31622204
51negative regulation of mRNA processing (GO:0050686)3.30952320
52translesion synthesis (GO:0019985)3.30134049
53regulation of RNA export from nucleus (GO:0046831)3.28752271
54RNA stabilization (GO:0043489)3.25727466
55mRNA stabilization (GO:0048255)3.25727466
56nucleobase biosynthetic process (GO:0046112)3.24649243
57ribosomal small subunit biogenesis (GO:0042274)3.24411833
58IMP metabolic process (GO:0046040)3.23776237
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23584008
60adherens junction assembly (GO:0034333)3.18503705
61DNA replication-dependent nucleosome assembly (GO:0006335)3.17536810
62DNA replication-dependent nucleosome organization (GO:0034723)3.17536810
63protein localization to chromosome, centromeric region (GO:0071459)3.17179685
64regulation of NFAT protein import into nucleus (GO:0051532)3.16717056
65negative regulation of mRNA metabolic process (GO:1903312)3.16071079
66cell-substrate adherens junction assembly (GO:0007045)3.13681393
67focal adhesion assembly (GO:0048041)3.13681393
68histone H2A acetylation (GO:0043968)3.10002207
69regulation of nucleobase-containing compound transport (GO:0032239)3.09882814
70protein complex disassembly (GO:0043241)3.09786881
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08744412
72mRNA splicing, via spliceosome (GO:0000398)3.05655392
73RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.05655392
74regulation of protein heterodimerization activity (GO:0043497)3.05412777
75sister chromatid segregation (GO:0000819)3.04695004
76nuclear pore organization (GO:0006999)3.04196818
77spliceosomal tri-snRNP complex assembly (GO:0000244)3.04193657
78regulation of histone H3-K9 methylation (GO:0051570)3.03936386
79glucose catabolic process (GO:0006007)3.03392142
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03034526
81maturation of SSU-rRNA (GO:0030490)3.00552101
82RNA splicing, via transesterification reactions (GO:0000375)3.00397025
83mitotic sister chromatid segregation (GO:0000070)2.98833204
84cellular protein complex disassembly (GO:0043624)2.97171974
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96780254
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96780254
87protein targeting to ER (GO:0045047)2.96683011
883-UTR-mediated mRNA stabilization (GO:0070935)2.96161018
89ncRNA 3-end processing (GO:0043628)2.95991591
90regulation of early endosome to late endosome transport (GO:2000641)2.95423853
91nuclear envelope organization (GO:0006998)2.94385779
92alternative mRNA splicing, via spliceosome (GO:0000380)2.94226116
93cotranslational protein targeting to membrane (GO:0006613)2.93845521
94protein maturation by protein folding (GO:0022417)2.93015149
95maternal placenta development (GO:0001893)2.93012007
96regulation of histone H3-K27 methylation (GO:0061085)2.92982155
97establishment of integrated proviral latency (GO:0075713)2.92979152
98nuclear pore complex assembly (GO:0051292)2.91431954
99telomere maintenance via telomere lengthening (GO:0010833)2.90544076
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87722010
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.87722010
102macromolecular complex disassembly (GO:0032984)2.86653266
103viral life cycle (GO:0019058)2.86534455
104intracellular estrogen receptor signaling pathway (GO:0030520)2.85653992
105cellular response to epidermal growth factor stimulus (GO:0071364)2.84963451
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83232818
107snRNA metabolic process (GO:0016073)2.82958711
108negative regulation of cell size (GO:0045792)2.82896325
109rRNA transcription (GO:0009303)2.82491342
110pentose-phosphate shunt (GO:0006098)2.82197630
111base-excision repair (GO:0006284)2.82178514
112mitotic G1/S transition checkpoint (GO:0044819)2.81536066
113postreplication repair (GO:0006301)2.81274926
114NADPH regeneration (GO:0006740)2.79881513
115telomere maintenance via recombination (GO:0000722)2.79525647
116corticosteroid receptor signaling pathway (GO:0031958)2.79406608
117poly(A)+ mRNA export from nucleus (GO:0016973)2.77757850
118positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.77212926
119modulation by virus of host process (GO:0019054)2.74151362
120protein localization to endoplasmic reticulum (GO:0070972)2.73249064
121mitotic recombination (GO:0006312)2.73140337
122DNA replication checkpoint (GO:0000076)2.71679052
123negative regulation of erythrocyte differentiation (GO:0045647)2.71226507
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.68927512
125pteridine-containing compound biosynthetic process (GO:0042559)2.68618379
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67765802
127regulation of chromatin binding (GO:0035561)2.67366885
128regulation of gene silencing by RNA (GO:0060966)2.66809333
129regulation of posttranscriptional gene silencing (GO:0060147)2.66809333
130regulation of gene silencing by miRNA (GO:0060964)2.66809333
131positive regulation of nuclease activity (GO:0032075)2.66750099
132polarized epithelial cell differentiation (GO:0030859)2.65964214
133termination of RNA polymerase II transcription (GO:0006369)2.65075490
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.64907873
135convergent extension (GO:0060026)2.61496772
136cellular response to interleukin-4 (GO:0071353)2.60589305
137negative regulation of viral release from host cell (GO:1902187)2.59462133
138histone H4 deacetylation (GO:0070933)2.58749292
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.58303816
140protein localization to endosome (GO:0036010)2.57750976
141modulation by virus of host morphology or physiology (GO:0019048)2.56766827
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.54668479
143basement membrane organization (GO:0071711)2.51986697
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51695710
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.51507898
146embryonic process involved in female pregnancy (GO:0060136)2.51457268
147UV protection (GO:0009650)2.51248565
148pinocytosis (GO:0006907)2.49006743
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.46866938
150folic acid metabolic process (GO:0046655)2.46471778
151protein export from nucleus (GO:0006611)2.45505825
152viral mRNA export from host cell nucleus (GO:0046784)2.43989147
153semaphorin-plexin signaling pathway (GO:0071526)2.42386614
154modulation by symbiont of host cellular process (GO:0044068)2.41701461
155nuclear envelope reassembly (GO:0031468)2.41488437
156mitotic nuclear envelope reassembly (GO:0007084)2.41488437
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41359641
158regulation of nuclease activity (GO:0032069)2.41163990
159snRNA processing (GO:0016180)2.39953114
160protein complex localization (GO:0031503)2.39832831
161regulation of mRNA stability (GO:0043488)2.39521611
162activation of MAPKKK activity (GO:0000185)2.38540057
163glucose 6-phosphate metabolic process (GO:0051156)2.37674282
164cellular hyperosmotic response (GO:0071474)2.37276880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.94731502
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93673573
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.73261567
4MYC_22102868_ChIP-Seq_BL_Human3.50949075
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.25147707
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.83670707
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54267397
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43710507
9VDR_21846776_ChIP-Seq_THP-1_Human2.38983843
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31091805
11CIITA_25753668_ChIP-Seq_RAJI_Human2.27338348
12XRN2_22483619_ChIP-Seq_HELA_Human2.22297913
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.17336284
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16602364
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06217175
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01789513
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00294436
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99469514
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98713389
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86342993
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77153614
22* ETS1_20019798_ChIP-Seq_JURKAT_Human1.75887587
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74548881
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70608628
25TCF7_22412390_ChIP-Seq_EML_Mouse1.65368778
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.62062312
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61611204
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59931412
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59819304
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.58796299
31* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58409766
32KDM2B_26808549_Chip-Seq_DND41_Human1.56476922
33* TET1_21451524_ChIP-Seq_MESCs_Mouse1.56457581
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55755979
35AR_21909140_ChIP-Seq_LNCAP_Human1.54559353
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51385917
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.49643411
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49174817
39GABP_19822575_ChIP-Seq_HepG2_Human1.48990422
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48496925
41* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43212347
42LXR_22292898_ChIP-Seq_THP-1_Human1.43014060
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41940081
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41498376
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40523459
46UTX_26944678_Chip-Seq_JUKART_Human1.40297264
47* KDM2B_26808549_Chip-Seq_K562_Human1.40048694
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39869427
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39736738
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39721031
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39670369
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38821197
53FOXP3_21729870_ChIP-Seq_TREG_Human1.37263862
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35834501
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.33806953
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33448181
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32771156
58TTF2_22483619_ChIP-Seq_HELA_Human1.32751139
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32179054
60* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32036275
61DCP1A_22483619_ChIP-Seq_HELA_Human1.31354643
62* MAF_26560356_Chip-Seq_TH1_Human1.31160867
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.31105677
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30952880
65KDM5A_27292631_Chip-Seq_BREAST_Human1.30624448
66* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30603360
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29670548
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.29348516
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29195875
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25949371
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25796655
72NCOR1_26117541_ChIP-Seq_K562_Human1.25294688
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22990396
74SCL_19346495_ChIP-Seq_HPC-7_Human1.22823821
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.22308707
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21660078
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20249541
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19843759
79* SMC4_20622854_ChIP-Seq_HELA_Human1.19222557
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19157467
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18987502
82* CREB1_26743006_Chip-Seq_LNCaP_Human1.18823081
83VDR_23849224_ChIP-Seq_CD4+_Human1.16999117
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16603445
85VDR_24763502_ChIP-Seq_THP-1_Human1.14507849
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14316785
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13872291
88* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13478457
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13153590
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11992508
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11813639
92TFEB_21752829_ChIP-Seq_HELA_Human1.11270939
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11127041
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10993404
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.09140154
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07819579
97ZNF263_19887448_ChIP-Seq_K562_Human1.07238775
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07046854
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06507410
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06366345
101* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06226054
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.05899041
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05561468
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05378928
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04757942
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04633158
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04300954
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03668659
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03638257
110P68_20966046_ChIP-Seq_HELA_Human1.03541224
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03497237
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02478758
113* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02238047
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02194167
115MAF_26560356_Chip-Seq_TH2_Human1.00997193
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00919105
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00632373
118* RACK7_27058665_Chip-Seq_MCF-7_Human1.00183342
119* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00084953
120TP53_22127205_ChIP-Seq_IMR90_Human1.00074849
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00053804
122* ATF3_27146783_Chip-Seq_COLON_Human0.99990960
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99509731
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99168173
125FOXP1_21924763_ChIP-Seq_HESCs_Human0.99111983
126ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98889662
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98604828
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98410559
129* RARA_24833708_ChIP-Seq_LIVER_Mouse0.97699074
130CLOCK_20551151_ChIP-Seq_293T_Human0.97626453
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97467481
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97379396
133YY1_21170310_ChIP-Seq_MESCs_Mouse0.97166141
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.96495465
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.91774667
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.91650540
137* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91480534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.24584362
2MP0010352_gastrointestinal_tract_polyps3.11704613
3MP0003077_abnormal_cell_cycle3.05677772
4MP0003123_paternal_imprinting3.05291538
5MP0003693_abnormal_embryo_hatching3.04215666
6MP0004957_abnormal_blastocyst_morpholog2.98438449
7MP0010094_abnormal_chromosome_stability2.94466609
8MP0004185_abnormal_adipocyte_glucose2.71478311
9MP0003705_abnormal_hypodermis_morpholog2.65917621
10MP0001730_embryonic_growth_arrest2.65050691
11MP0002396_abnormal_hematopoietic_system2.52854239
12MP0009278_abnormal_bone_marrow2.42105279
13MP0004808_abnormal_hematopoietic_stem2.40807751
14MP0003283_abnormal_digestive_organ2.36793846
15MP0005451_abnormal_body_composition2.32050731
16MP0008007_abnormal_cellular_replicative2.29096996
17MP0008260_abnormal_autophagy2.26666452
18MP0002653_abnormal_ependyma_morphology2.19091976
19MP0008057_abnormal_DNA_replication2.15001700
20MP0006054_spinal_hemorrhage2.14735661
21MP0000350_abnormal_cell_proliferation2.11366176
22MP0005058_abnormal_lysosome_morphology2.10698879
23MP0010030_abnormal_orbit_morphology2.10677766
24* MP0005076_abnormal_cell_differentiation1.99335987
25MP0005397_hematopoietic_system_phenotyp1.93860653
26MP0001545_abnormal_hematopoietic_system1.93860653
27MP0002249_abnormal_larynx_morphology1.91639195
28MP0010307_abnormal_tumor_latency1.91589839
29MP0004197_abnormal_fetal_growth/weight/1.91425360
30MP0008058_abnormal_DNA_repair1.86979208
31* MP0001697_abnormal_embryo_size1.86211314
32MP0002796_impaired_skin_barrier1.85944558
33* MP0002080_prenatal_lethality1.81731766
34MP0001348_abnormal_lacrimal_gland1.78273748
35MP0002084_abnormal_developmental_patter1.77965536
36MP0003315_abnormal_perineum_morphology1.74032254
37MP0008961_abnormal_basal_metabolism1.73124699
38* MP0002085_abnormal_embryonic_tissue1.71417399
39MP0003119_abnormal_digestive_system1.68821587
40MP0005501_abnormal_skin_physiology1.65933340
41* MP0005380_embryogenesis_phenotype1.64007864
42* MP0001672_abnormal_embryogenesis/_devel1.64007864
43MP0001849_ear_inflammation1.61022055
44MP0000703_abnormal_thymus_morphology1.60543587
45MP0000490_abnormal_crypts_of1.59311031
46MP0000537_abnormal_urethra_morphology1.58478310
47* MP0003984_embryonic_growth_retardation1.58133197
48MP0003172_abnormal_lysosome_physiology1.57480824
49MP0001873_stomach_inflammation1.56721598
50MP0004264_abnormal_extraembryonic_tissu1.56237035
51* MP0002088_abnormal_embryonic_growth/wei1.54989520
52MP0002086_abnormal_extraembryonic_tissu1.54924742
53MP0004233_abnormal_muscle_weight1.53160821
54MP0003763_abnormal_thymus_physiology1.50374967
55MP0002089_abnormal_postnatal_growth/wei1.50265802
56MP0000313_abnormal_cell_death1.44020067
57MP0005666_abnormal_adipose_tissue1.43670971
58MP0009672_abnormal_birth_weight1.42372850
59MP0008932_abnormal_embryonic_tissue1.40178302
60* MP0002019_abnormal_tumor_incidence1.39425694
61MP0000566_synostosis1.39367386
62MP0003121_genomic_imprinting1.37518741
63MP0005409_darkened_coat_color1.36354100
64MP0002398_abnormal_bone_marrow1.34916119
65MP0001915_intracranial_hemorrhage1.33355396
66MP0003122_maternal_imprinting1.31525329
67MP0001346_abnormal_lacrimal_gland1.28393556
68* MP0000678_abnormal_parathyroid_gland1.25977213
69MP0003453_abnormal_keratinocyte_physiol1.25741042
70MP0003566_abnormal_cell_adhesion1.25302469
71MP0009333_abnormal_splenocyte_physiolog1.22083363
72MP0002722_abnormal_immune_system1.19338683
73MP0005623_abnormal_meninges_morphology1.17690873
74MP0003942_abnormal_urinary_system1.16522850
75MP0005375_adipose_tissue_phenotype1.14011202
76MP0003567_abnormal_fetal_cardiomyocyte1.10766818
77MP0009053_abnormal_anal_canal1.09207525
78MP0000428_abnormal_craniofacial_morphol1.08953920
79MP0003436_decreased_susceptibility_to1.06969833
80MP0002009_preneoplasia1.06517654
81MP0005394_taste/olfaction_phenotype1.06469713
82MP0005499_abnormal_olfactory_system1.06469713
83MP0003115_abnormal_respiratory_system1.06110515
84MP0000534_abnormal_ureter_morphology1.06058089
85MP0000689_abnormal_spleen_morphology1.05426619
86MP0001293_anophthalmia1.05400446
87MP0005257_abnormal_intraocular_pressure1.04080358
88MP0003303_peritoneal_inflammation1.03317707
89MP0002234_abnormal_pharynx_morphology1.02557891
90MP0008770_decreased_survivor_rate1.02062650
91MP0005023_abnormal_wound_healing1.01662197
92MP0002932_abnormal_joint_morphology1.00773169
93MP0003300_gastrointestinal_ulcer1.00570075
94MP0000685_abnormal_immune_system1.00537945
95MP0008789_abnormal_olfactory_epithelium0.99175242
96MP0009703_decreased_birth_body0.97598082
97MP0004133_heterotaxia0.96602942
98MP0000358_abnormal_cell_content/0.95769363
99MP0002429_abnormal_blood_cell0.93105151
100MP0003091_abnormal_cell_migration0.92155565
101MP0009931_abnormal_skin_appearance0.90970744
102MP0002060_abnormal_skin_morphology0.90837319
103MP0005187_abnormal_penis_morphology0.90732493
104MP0000477_abnormal_intestine_morphology0.90354217
105MP0001661_extended_life_span0.89927044
106MP0009384_cardiac_valve_regurgitation0.89193474
107* MP0003861_abnormal_nervous_system0.88462333
108MP0008438_abnormal_cutaneous_collagen0.85547756
109MP0009840_abnormal_foam_cell0.85175285
110MP0002925_abnormal_cardiovascular_devel0.84476592
111* MP0005384_cellular_phenotype0.83313198
112MP0000733_abnormal_muscle_development0.83270315
113MP0004947_skin_inflammation0.83160997
114MP0004858_abnormal_nervous_system0.82406189
115* MP0010630_abnormal_cardiac_muscle0.82389834
116MP0008877_abnormal_DNA_methylation0.81898952
117MP0010234_abnormal_vibrissa_follicle0.81898257
118MP0000462_abnormal_digestive_system0.81605400
119MP0003385_abnormal_body_wall0.80228673
120* MP0005621_abnormal_cell_physiology0.79736796
121MP0002111_abnormal_tail_morphology0.79458134
122MP0000716_abnormal_immune_system0.78440906
123MP0002092_abnormal_eye_morphology0.78034260
124MP0004381_abnormal_hair_follicle0.78030498
125* MP0000858_altered_metastatic_potential0.77312120
126MP0002098_abnormal_vibrissa_morphology0.76629388
127MP0001216_abnormal_epidermal_layer0.75789927
128MP0000467_abnormal_esophagus_morphology0.75019229
129MP0002114_abnormal_axial_skeleton0.71314057
130* MP0005220_abnormal_exocrine_pancreas0.70920798
131MP0004272_abnormal_basement_membrane0.69328290
132MP0002877_abnormal_melanocyte_morpholog0.67857324
133MP0002909_abnormal_adrenal_gland0.65338966
134* MP0003935_abnormal_craniofacial_develop0.64203929
135MP0002697_abnormal_eye_size0.64148043
136* MP0000266_abnormal_heart_morphology0.63560781
137* MP0000598_abnormal_liver_morphology0.62081557
138MP0000003_abnormal_adipose_tissue0.61800367

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.25680473
2Ependymoma (HP:0002888)3.91974303
3Renal duplication (HP:0000075)3.33568945
4Short 4th metacarpal (HP:0010044)3.28491744
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.28491744
6Broad face (HP:0000283)3.18502332
7Basal cell carcinoma (HP:0002671)3.05681738
8Colon cancer (HP:0003003)3.02705009
9Protrusio acetabuli (HP:0003179)2.98305764
10Insomnia (HP:0100785)2.93614983
11Abnormality of the astrocytes (HP:0100707)2.87428393
12Astrocytoma (HP:0009592)2.87428393
13Increased nuchal translucency (HP:0010880)2.87404178
14Ulnar bowing (HP:0003031)2.84641445
15Elfin facies (HP:0004428)2.83097223
16Flat acetabular roof (HP:0003180)2.75430811
17Bowel diverticulosis (HP:0005222)2.71905938
18Medulloblastoma (HP:0002885)2.71849861
19Disproportionate tall stature (HP:0001519)2.68494980
20Thrombocytosis (HP:0001894)2.66363072
21Obstructive sleep apnea (HP:0002870)2.66165900
22Hand muscle atrophy (HP:0009130)2.65374608
23Pointed chin (HP:0000307)2.65286573
24Selective tooth agenesis (HP:0001592)2.63865396
25Abnormality of the anterior horn cell (HP:0006802)2.63538455
26Degeneration of anterior horn cells (HP:0002398)2.63538455
27Abnormality of the 4th metacarpal (HP:0010012)2.59123088
28Achilles tendon contracture (HP:0001771)2.55429623
29Renovascular hypertension (HP:0100817)2.54475868
30Abnormality of cells of the erythroid lineage (HP:0012130)2.42790118
31Broad distal phalanx of finger (HP:0009836)2.40312789
32Abnormality of the distal phalanx of the thumb (HP:0009617)2.39707487
33Ankle contracture (HP:0006466)2.39629573
34Amaurosis fugax (HP:0100576)2.37955208
35Shallow orbits (HP:0000586)2.37878846
36Abnormality of the lower motor neuron (HP:0002366)2.36409143
37Premature skin wrinkling (HP:0100678)2.34276126
38Overriding aorta (HP:0002623)2.33240337
39Enlarged penis (HP:0000040)2.31948602
40Abnormal number of erythroid precursors (HP:0012131)2.30492593
41Abnormality of the Achilles tendon (HP:0005109)2.30007028
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.28510669
43Neoplasm of the oral cavity (HP:0100649)2.27215553
44Cerebral aneurysm (HP:0004944)2.25380376
45Distal upper limb amyotrophy (HP:0007149)2.24687719
46Upper limb amyotrophy (HP:0009129)2.24687719
47Neoplasm of striated muscle (HP:0009728)2.24519913
48Reticulocytopenia (HP:0001896)2.22236750
49Trismus (HP:0000211)2.21912625
50Rhabdomyosarcoma (HP:0002859)2.21891569
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.21201879
52Broad palm (HP:0001169)2.21015814
53Abnormality of the thoracic spine (HP:0100711)2.20161151
54Biconcave vertebral bodies (HP:0004586)2.19063784
55High pitched voice (HP:0001620)2.15882886
56Ankyloglossia (HP:0010296)2.15819900
57Annular pancreas (HP:0001734)2.12633334
58Cutaneous melanoma (HP:0012056)2.10873938
59Glioma (HP:0009733)2.10767401
60Thin bony cortex (HP:0002753)2.09177780
61Abnormality of the fingertips (HP:0001211)2.08968179
62Intestinal polyp (HP:0005266)2.08537980
63Proximal placement of thumb (HP:0009623)2.08470039
64Abnormality of the phalanges of the hallux (HP:0010057)2.07944476
65Urethral obstruction (HP:0000796)2.07864663
66Aplastic anemia (HP:0001915)2.07442664
67Pseudobulbar signs (HP:0002200)2.07153114
68Stridor (HP:0010307)2.06646350
69Vertebral compression fractures (HP:0002953)2.06161464
70Deviation of the thumb (HP:0009603)2.05520349
71Long eyelashes (HP:0000527)2.04970289
72Long palpebral fissure (HP:0000637)2.04932913
73Patellar dislocation (HP:0002999)2.04167568
74Metaphyseal cupping (HP:0003021)2.03793388
75Megalocornea (HP:0000485)2.03295871
76Flat cornea (HP:0007720)2.02575449
77Cervical subluxation (HP:0003308)2.02097288
78Asymmetry of the thorax (HP:0001555)2.01884847
79Cholecystitis (HP:0001082)2.00427087
80Abnormal gallbladder physiology (HP:0012438)2.00427087
81Skin tags (HP:0010609)1.99702354
82Septate vagina (HP:0001153)1.99295842
83Abnormality of oral frenula (HP:0000190)1.99127095
84Truncus arteriosus (HP:0001660)1.96793379
85Testicular atrophy (HP:0000029)1.94927352
86Genu recurvatum (HP:0002816)1.94768899
87Intestinal polyposis (HP:0200008)1.94391632
88Spastic diplegia (HP:0001264)1.93766059
89Oral leukoplakia (HP:0002745)1.93223227
90Progressive muscle weakness (HP:0003323)1.92527482
91Microvesicular hepatic steatosis (HP:0001414)1.92036290
92Mitral regurgitation (HP:0001653)1.91975012
93Premature rupture of membranes (HP:0001788)1.91713966
94Patellar aplasia (HP:0006443)1.90392245
95Deep palmar crease (HP:0006191)1.89737497
96Bronchomalacia (HP:0002780)1.89598499
97Myopathic facies (HP:0002058)1.89247861
98Abnormality of the distal phalanges of the toes (HP:0010182)1.88037334
99Distal lower limb amyotrophy (HP:0008944)1.87228665
100Deep venous thrombosis (HP:0002625)1.86581411
101Reticulocytosis (HP:0001923)1.85653933
102Hallux valgus (HP:0001822)1.84541122
103Bladder diverticulum (HP:0000015)1.84319498
104Increased density of long bones (HP:0006392)1.82885580
105* Angiofibromas (HP:0010615)1.82850610
106* Adenoma sebaceum (HP:0009720)1.82850610
107Hypertensive crisis (HP:0100735)1.82849385
108Short phalanx of the thumb (HP:0009660)1.82395718
109Multiple enchondromatosis (HP:0005701)1.82393625
110Abnormal number of incisors (HP:0011064)1.82306332
111Sacral dimple (HP:0000960)1.81793555
112Ragged-red muscle fibers (HP:0003200)1.81170668
113Hypoplasia of the pons (HP:0012110)1.81084949
114Aplasia/Hypoplasia of the patella (HP:0006498)1.81066734
115Cutis marmorata (HP:0000965)1.81066311
116Syringomyelia (HP:0003396)1.80133834
117Spinal cord lesions (HP:0100561)1.80133834
118Abnormality of the motor neurons (HP:0002450)1.79447128
119Abnormal neuron morphology (HP:0012757)1.79447128
120Missing ribs (HP:0000921)1.78989412
121High anterior hairline (HP:0009890)1.78886516
122Overlapping toe (HP:0001845)1.78171648
123Abnormal ossification of hand bones (HP:0005921)1.78142902
124Cellulitis (HP:0100658)1.77796454
125Preauricular skin tag (HP:0000384)1.77359050
126Abnormality of carpal bone ossification (HP:0006257)1.77184750
127Seborrheic dermatitis (HP:0001051)1.77047876
128Dysmetric saccades (HP:0000641)1.77017670
129Dislocated radial head (HP:0003083)1.76121457
130Deviation of the hallux (HP:0010051)1.75823755
131Pelvic girdle muscle weakness (HP:0003749)1.74464796
13211 pairs of ribs (HP:0000878)1.74189082
133Sparse lateral eyebrow (HP:0005338)1.73638160
134Hyperthyroidism (HP:0000836)1.73506147
135IgM deficiency (HP:0002850)1.72545410
136Polygenic inheritance (HP:0010982)1.72207354
137Spinal muscular atrophy (HP:0007269)1.72199446
138Turricephaly (HP:0000262)1.71236596
139Papilloma (HP:0012740)1.70880922
140Verrucae (HP:0200043)1.70880922
141Thoracic kyphosis (HP:0002942)1.70807265
142Easy fatigability (HP:0003388)1.70700315
143Vertebral arch anomaly (HP:0008438)1.70437595
144Thin ribs (HP:0000883)1.70152133
145Advanced eruption of teeth (HP:0006288)1.69790441
146Hemorrhage of the eye (HP:0011885)1.69691947
147Atresia of the external auditory canal (HP:0000413)1.69470436
148Neoplasm of the heart (HP:0100544)1.69469620
149Blue sclerae (HP:0000592)1.69326945
150* Neoplasm of the pancreas (HP:0002894)1.68469077
151Agnosia (HP:0010524)1.68121578
152Abnormal vertebral ossification (HP:0100569)1.67989205
153Fragile skin (HP:0001030)1.67979436
154Limb-girdle muscle atrophy (HP:0003797)1.67714364
155Flattened epiphyses (HP:0003071)1.67478233
156Back pain (HP:0003418)1.66791867
157Squamous cell carcinoma (HP:0002860)1.66071565
158Abnormality of the radial head (HP:0003995)1.64948339
159Arnold-Chiari malformation (HP:0002308)1.64550051
160Vertebral hypoplasia (HP:0008417)1.63634304
161Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63634304
162Slender long bone (HP:0003100)1.62404794
163Unilateral renal agenesis (HP:0000122)1.62402125
164Severe short stature (HP:0003510)1.61908776
165Amyotrophic lateral sclerosis (HP:0007354)1.60830139
166Atelectasis (HP:0100750)1.60535303
167Trigonocephaly (HP:0000243)1.60029323
168Flared metaphyses (HP:0003015)1.59737012
169Germ cell neoplasia (HP:0100728)1.59065044
170Bowel incontinence (HP:0002607)1.58625731
171J-shaped sella turcica (HP:0002680)1.58531430
172Diaphragmatic weakness (HP:0009113)1.58330811
173Hypoparathyroidism (HP:0000829)1.55652011
174Abnormality of the aortic arch (HP:0012303)1.55276500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.75178037
2SMG14.29190289
3MAP3K103.73371528
4PKN23.59389270
5TRIB33.39169185
6PASK2.95081451
7CDC72.82947444
8PRPF4B2.78717453
9ERN12.44286668
10NEK22.43020810
11BUB12.26478756
12IRAK32.16385824
13WEE12.01225026
14NEK11.90127925
15CDK121.84583267
16TESK21.83891311
17SCYL21.83795780
18PAK41.78271161
19TSSK61.71609275
20TGFBR11.70255320
21RPS6KB21.68859127
22MAP4K11.62215630
23LRRK21.59907092
24FGFR41.56784726
25FLT31.55034524
26VRK21.54320966
27EPHA21.48761569
28ARAF1.42607961
29ALK1.37895505
30STK101.33505588
31PTK61.32291770
32PRKD21.28121106
33CCNB11.27371531
34SIK11.27275947
35CDK41.20288757
36MAPKAPK31.17523243
37MAP3K81.16867818
38SIK21.16293334
39ICK1.15940347
40MARK21.13836558
41CAMK1D1.12679166
42GRK61.11071171
43PRKD31.08646946
44BTK1.06418278
45MAP3K131.04037516
46KSR11.03421564
47CDK71.03280641
48ATR1.02744756
49MTOR1.01046970
50TNK20.99312293
51BCKDK0.96397594
52NME20.92351981
53PDGFRA0.90923107
54KDR0.90745501
55SIK30.90254757
56PLK10.88747512
57TTK0.88636563
58EIF2AK10.87206568
59BRSK10.86945547
60BRAF0.86373911
61RPS6KA40.85356690
62KSR20.84174368
63ZAP700.82206257
64PIM20.79910728
65CLK10.76797936
66TESK10.76668013
67CHEK10.76084565
68UHMK10.74416345
69CAMK1G0.74284784
70MST1R0.74180263
71DAPK10.73177360
72AURKB0.70219671
73AURKA0.68885265
74RPS6KL10.68545552
75RPS6KC10.68545552
76CDK90.68088438
77CDK20.67852852
78BRD40.67075148
79PDPK10.65955488
80CAMKK10.65889454
81RIPK10.65855102
82TAOK10.65822075
83IRAK20.61620938
84PAK20.59951379
85PAK10.59752376
86CDK80.59071692
87MAP3K90.59025810
88TYRO30.58903386
89MAP2K30.56984670
90DYRK30.56637528
91CDC42BPA0.55378221
92FGFR10.54440359
93ILK0.53651003
94PRKCI0.52810010
95BMX0.52791980
96MAP3K10.52713316
97LATS20.52007642
98CDK60.51662613
99EPHB10.51477808
100MAP3K110.49565362
101RIPK40.49303763
102CHEK20.48792846
103CDK11A0.48529612
104JAK30.48398240
105AKT20.48184287
106STK40.47363057
107MAPK110.46725115
108RPS6KA60.46187544
109CDK180.45832126
110CDK150.45805616
111RPS6KA20.45016588
112BRSK20.44598732
113PTK20.44042703
114TAOK20.43848577
115MINK10.43260296
116RET0.42304244
117MAP3K30.41643224
118CDK140.41574542
119TYK20.41550625
120TTN0.40807699
121RPS6KA10.40798838
122IRAK40.40529518
123MAP2K20.39379262
124PIM10.39065172
125MAP3K70.38649845
126LMTK20.37919246
127CDK10.37796050
128TBK10.37357977
129TLK10.36855154
130PLK30.36358533
131HIPK20.36324546
132PAK60.36275957
133PDK10.35695632
134MAPKAPK20.35329271
135RAF10.34995939
136NTRK10.33618806
137DYRK1B0.32074715

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35153789
2Mismatch repair_Homo sapiens_hsa034303.36144441
3Base excision repair_Homo sapiens_hsa034103.03917080
4Spliceosome_Homo sapiens_hsa030402.89585366
5RNA transport_Homo sapiens_hsa030132.50941568
6One carbon pool by folate_Homo sapiens_hsa006702.27810030
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25981041
8Cell cycle_Homo sapiens_hsa041102.23353217
9Ribosome_Homo sapiens_hsa030102.17992240
10Other glycan degradation_Homo sapiens_hsa005111.96335387
11mRNA surveillance pathway_Homo sapiens_hsa030151.92479143
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85750719
13Nucleotide excision repair_Homo sapiens_hsa034201.66354684
14Chronic myeloid leukemia_Homo sapiens_hsa052201.65256286
15Notch signaling pathway_Homo sapiens_hsa043301.43338391
16Fructose and mannose metabolism_Homo sapiens_hsa000511.36186995
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35001620
18Pyrimidine metabolism_Homo sapiens_hsa002401.34910783
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34852966
20Thyroid cancer_Homo sapiens_hsa052161.31217878
21Non-small cell lung cancer_Homo sapiens_hsa052231.29991122
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.27149574
23Colorectal cancer_Homo sapiens_hsa052101.26652308
24Oocyte meiosis_Homo sapiens_hsa041141.25589620
25N-Glycan biosynthesis_Homo sapiens_hsa005101.25449446
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.24964462
27Biosynthesis of amino acids_Homo sapiens_hsa012301.22581740
28Sulfur relay system_Homo sapiens_hsa041221.22156434
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21397352
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21376403
31Prostate cancer_Homo sapiens_hsa052151.20378102
32Homologous recombination_Homo sapiens_hsa034401.19307329
33Prion diseases_Homo sapiens_hsa050201.19187760
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.16717466
35RNA polymerase_Homo sapiens_hsa030201.16052083
36Non-homologous end-joining_Homo sapiens_hsa034501.15981107
37HTLV-I infection_Homo sapiens_hsa051661.14910586
38ErbB signaling pathway_Homo sapiens_hsa040121.13275987
39Acute myeloid leukemia_Homo sapiens_hsa052211.10976278
40mTOR signaling pathway_Homo sapiens_hsa041501.09832291
41Viral carcinogenesis_Homo sapiens_hsa052031.09512660
42Bladder cancer_Homo sapiens_hsa052191.06327567
43p53 signaling pathway_Homo sapiens_hsa041151.05434349
44Selenocompound metabolism_Homo sapiens_hsa004501.04413365
45Glioma_Homo sapiens_hsa052141.02219405
46Endometrial cancer_Homo sapiens_hsa052131.00126411
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99829767
48MicroRNAs in cancer_Homo sapiens_hsa052060.98077459
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97658600
50B cell receptor signaling pathway_Homo sapiens_hsa046620.96880605
51RNA degradation_Homo sapiens_hsa030180.96422182
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94940093
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.93610789
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91331908
55Epstein-Barr virus infection_Homo sapiens_hsa051690.90783423
56Antigen processing and presentation_Homo sapiens_hsa046120.89460240
57Basal cell carcinoma_Homo sapiens_hsa052170.87999415
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87975928
59Shigellosis_Homo sapiens_hsa051310.87810064
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87780184
61VEGF signaling pathway_Homo sapiens_hsa043700.84883610
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84021675
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83886331
64Primary immunodeficiency_Homo sapiens_hsa053400.83373367
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81868475
66Small cell lung cancer_Homo sapiens_hsa052220.81343472
67Hepatitis B_Homo sapiens_hsa051610.79704101
68Pentose phosphate pathway_Homo sapiens_hsa000300.79654053
69Choline metabolism in cancer_Homo sapiens_hsa052310.78980774
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.78182135
71Inositol phosphate metabolism_Homo sapiens_hsa005620.78117184
72Hippo signaling pathway_Homo sapiens_hsa043900.77332094
73Lysine degradation_Homo sapiens_hsa003100.73100341
74Hedgehog signaling pathway_Homo sapiens_hsa043400.72870501
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72514302
76Pancreatic cancer_Homo sapiens_hsa052120.71739783
77Vitamin B6 metabolism_Homo sapiens_hsa007500.70660882
78Herpes simplex infection_Homo sapiens_hsa051680.70565148
79Estrogen signaling pathway_Homo sapiens_hsa049150.70146794
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.69883320
81HIF-1 signaling pathway_Homo sapiens_hsa040660.68998160
82Proteoglycans in cancer_Homo sapiens_hsa052050.68306523
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67988002
84Viral myocarditis_Homo sapiens_hsa054160.67958597
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67759432
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.66213782
87Hepatitis C_Homo sapiens_hsa051600.65370664
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65067522
89Proteasome_Homo sapiens_hsa030500.64844965
90Endocytosis_Homo sapiens_hsa041440.64016606
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61847210
92Apoptosis_Homo sapiens_hsa042100.61635160
93Legionellosis_Homo sapiens_hsa051340.61510396
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58890595
95Prolactin signaling pathway_Homo sapiens_hsa049170.58856830
96Insulin signaling pathway_Homo sapiens_hsa049100.58304047
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57561399
98Carbon metabolism_Homo sapiens_hsa012000.56466296
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56439341
100Wnt signaling pathway_Homo sapiens_hsa043100.55934647
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55822841
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55573751
103Alcoholism_Homo sapiens_hsa050340.54616233
104Vibrio cholerae infection_Homo sapiens_hsa051100.54600724
105GnRH signaling pathway_Homo sapiens_hsa049120.53438755
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.52531235
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51306687
108Galactose metabolism_Homo sapiens_hsa000520.51196331
109Platelet activation_Homo sapiens_hsa046110.50598848
110Melanogenesis_Homo sapiens_hsa049160.49755904
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49459264
112Pathways in cancer_Homo sapiens_hsa052000.49336966
113Insulin resistance_Homo sapiens_hsa049310.49236802
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48649650
115Long-term potentiation_Homo sapiens_hsa047200.48357042
116Influenza A_Homo sapiens_hsa051640.47691570
117Adherens junction_Homo sapiens_hsa045200.47654687
118Fatty acid biosynthesis_Homo sapiens_hsa000610.47432744
119T cell receptor signaling pathway_Homo sapiens_hsa046600.47385785
120Glucagon signaling pathway_Homo sapiens_hsa049220.47125412
121Gap junction_Homo sapiens_hsa045400.45717982
122AMPK signaling pathway_Homo sapiens_hsa041520.43840687
123Renal cell carcinoma_Homo sapiens_hsa052110.43799463
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42159230
125Purine metabolism_Homo sapiens_hsa002300.41605064
126Focal adhesion_Homo sapiens_hsa045100.40252538

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