MEOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.55665892
2triglyceride catabolic process (GO:0019433)7.21198348
3regulation of sequestering of triglyceride (GO:0010889)6.93779895
4acylglycerol catabolic process (GO:0046464)6.29308569
5neutral lipid catabolic process (GO:0046461)6.29308569
6lymph vessel development (GO:0001945)5.91284218
7venous blood vessel morphogenesis (GO:0048845)5.73062039
8cardiac myofibril assembly (GO:0055003)5.26322125
9NADH metabolic process (GO:0006734)5.16593618
10metanephric mesenchyme development (GO:0072075)5.16279341
11negative regulation of granulocyte differentiation (GO:0030853)5.11249251
12transcytosis (GO:0045056)5.08238826
13endocardial cushion morphogenesis (GO:0003203)4.85384792
14fatty acid homeostasis (GO:0055089)4.74451290
15retina vasculature morphogenesis in camera-type eye (GO:0061299)4.64158660
16cellular response to epinephrine stimulus (GO:0071872)4.58293360
17plasma membrane repair (GO:0001778)4.56467725
18cGMP-mediated signaling (GO:0019934)4.56108022
19sarcomere organization (GO:0045214)4.55249224
20vascular endothelial growth factor signaling pathway (GO:0038084)4.47556315
21glycerolipid catabolic process (GO:0046503)4.35599754
22myoblast migration (GO:0051451)4.34058326
23kidney mesenchyme development (GO:0072074)4.33587142
24myofibril assembly (GO:0030239)4.31829782
25extracellular fibril organization (GO:0043206)4.29780351
26heart trabecula formation (GO:0060347)4.29690251
27protein heterotrimerization (GO:0070208)4.26660690
28mesenchyme morphogenesis (GO:0072132)4.25240734
29COPI coating of Golgi vesicle (GO:0048205)4.20092881
30Golgi transport vesicle coating (GO:0048200)4.20092881
31lymphangiogenesis (GO:0001946)4.13799574
32endothelium development (GO:0003158)4.10302818
33glomerular filtration (GO:0003094)4.03655716
34fibril organization (GO:0097435)3.99488048
35regulation of glycogen (starch) synthase activity (GO:2000465)3.98442803
36lipid particle organization (GO:0034389)3.94621946
37peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.91959307
38blood vessel maturation (GO:0001955)3.90514422
39trabecula formation (GO:0060343)3.88901356
40polyol transport (GO:0015791)3.85219240
41response to dietary excess (GO:0002021)3.82122270
42collagen fibril organization (GO:0030199)3.81134649
43endothelial cell morphogenesis (GO:0001886)3.80962793
44response to epinephrine (GO:0071871)3.80703519
45lipid storage (GO:0019915)3.78774071
46diacylglycerol metabolic process (GO:0046339)3.75582469
47growth hormone secretion (GO:0030252)3.69254843
48positive regulation of lipoprotein lipase activity (GO:0051006)3.65765390
49positive regulation of triglyceride lipase activity (GO:0061365)3.65765390
50vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.64785035
51outflow tract septum morphogenesis (GO:0003148)3.63877242
52white fat cell differentiation (GO:0050872)3.61716608
53cellular response to lithium ion (GO:0071285)3.61276523
54regulation of cholesterol storage (GO:0010885)3.61110410
55renal filtration (GO:0097205)3.60990276
56positive regulation of lipid storage (GO:0010884)3.59984453
57brown fat cell differentiation (GO:0050873)3.59057639
58cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.57535168
59regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.50653921
60ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.50395816
61ethanol oxidation (GO:0006069)3.50123417
62cardiac muscle tissue morphogenesis (GO:0055008)3.47659671
63dermatan sulfate biosynthetic process (GO:0030208)3.42288293
64skeletal muscle tissue development (GO:0007519)3.38321588
65positive regulation of vasculogenesis (GO:2001214)3.37609195
66cardiac muscle cell proliferation (GO:0060038)3.36677183
67bone trabecula formation (GO:0060346)3.36252192
68patterning of blood vessels (GO:0001569)3.34885526
69oxaloacetate metabolic process (GO:0006107)3.34486143
70cardiac muscle cell development (GO:0055013)3.34411992
71negative regulation of macrophage differentiation (GO:0045650)3.34094591
72ovulation from ovarian follicle (GO:0001542)3.32908436
73keratan sulfate catabolic process (GO:0042340)3.31726085
74negative regulation of amino acid transport (GO:0051956)3.29346557
75positive regulation of glucose import (GO:0046326)3.28786235
76glomerular basement membrane development (GO:0032836)3.24603533
77negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.23155002
78fatty acid transmembrane transport (GO:1902001)3.22135163
79positive regulation of glomerulus development (GO:0090193)3.21956704
80negative regulation of cardiac muscle tissue growth (GO:0055022)3.21920373
81negative regulation of heart growth (GO:0061117)3.21920373
82cardiac cell development (GO:0055006)3.19583239
83basement membrane organization (GO:0071711)3.19500790
84artery development (GO:0060840)3.17620749
85regulation of cardioblast differentiation (GO:0051890)3.16562182
86barbed-end actin filament capping (GO:0051016)3.16263325
87negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.14751595
88negative regulation of cartilage development (GO:0061037)3.14629814
89positive regulation of cellular response to insulin stimulus (GO:1900078)3.14068585
90actomyosin structure organization (GO:0031032)3.12783695
91regulation of lipoprotein metabolic process (GO:0050746)3.12135624
92atrial septum morphogenesis (GO:0060413)3.11998665
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.11833979
94sequestering of extracellular ligand from receptor (GO:0035581)3.11673205
95positive regulation of odontogenesis (GO:0042482)3.09740220
96muscle filament sliding (GO:0030049)3.09001326
97actin-myosin filament sliding (GO:0033275)3.09001326
98CDP-diacylglycerol biosynthetic process (GO:0016024)3.08973057
99regulation of gonadotropin secretion (GO:0032276)3.08351967
100muscle tissue morphogenesis (GO:0060415)3.07945993
101negative regulation of potassium ion transmembrane transport (GO:1901380)3.07858510
102cell migration involved in heart development (GO:0060973)3.07677740
103embryonic heart tube development (GO:0035050)3.06570591
104dermatan sulfate metabolic process (GO:0030205)3.06255278
105regulation of endothelial cell differentiation (GO:0045601)3.03372028
106camera-type eye morphogenesis (GO:0048593)3.02424869
107negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.02402998
108creatine metabolic process (GO:0006600)2.99761644
109CDP-diacylglycerol metabolic process (GO:0046341)2.99722913
110negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.99473881
111phosphatidic acid metabolic process (GO:0046473)2.99024312
112phosphatidic acid biosynthetic process (GO:0006654)2.99024312
113regulation of striated muscle cell apoptotic process (GO:0010662)2.98483926
114regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.95304578
115regulation of actin filament-based movement (GO:1903115)2.94394870
116positive regulation of vascular permeability (GO:0043117)2.93647903
117regulation of macrophage derived foam cell differentiation (GO:0010743)2.92674087
118outer ear morphogenesis (GO:0042473)2.91979514
119adult heart development (GO:0007512)2.91640671
120regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.91397785
121tricarboxylic acid metabolic process (GO:0072350)2.90937751
122cellular response to monoamine stimulus (GO:0071868)2.90493942
123cellular response to catecholamine stimulus (GO:0071870)2.90493942
124endocrine hormone secretion (GO:0060986)2.90024046
125angiogenesis involved in wound healing (GO:0060055)2.88967799
126ethanol metabolic process (GO:0006067)2.88887841
127negative regulation of striated muscle cell apoptotic process (GO:0010664)2.88677218
128regulation of cardiac muscle cell apoptotic process (GO:0010665)2.88299043
129vasculogenesis (GO:0001570)2.87699358
130positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.86780932
131coronary vasculature morphogenesis (GO:0060977)2.86241649
132regulation of cAMP-dependent protein kinase activity (GO:2000479)2.84376890
133regulation of p38MAPK cascade (GO:1900744)2.82686369
134triglyceride biosynthetic process (GO:0019432)2.81783462
135negative regulation of kidney development (GO:0090185)2.81108792
136cardiac chamber morphogenesis (GO:0003206)2.81075901
137chondrocyte proliferation (GO:0035988)2.80491453
138atrioventricular valve morphogenesis (GO:0003181)2.79913069
139tyrosine phosphorylation of STAT protein (GO:0007260)2.79560033
140negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.79382968
141negative regulation of catenin import into nucleus (GO:0035414)2.78937670
142regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78611445
143negative regulation of gluconeogenesis (GO:0045721)2.78228195
144muscle cell migration (GO:0014812)2.78221797
145cardiac muscle contraction (GO:0060048)2.78076576
146morphogenesis of an endothelium (GO:0003159)2.77886260
147endothelial tube morphogenesis (GO:0061154)2.77886260
148paraxial mesoderm development (GO:0048339)2.77885533
149triglyceride metabolic process (GO:0006641)2.77815553
150negative regulation of smooth muscle cell proliferation (GO:0048662)2.75665533
151cell migration involved in sprouting angiogenesis (GO:0002042)2.75418930
152peripheral nervous system axon ensheathment (GO:0032292)2.74093768
153myelination in peripheral nervous system (GO:0022011)2.74093768
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.73651370
155nephron epithelium development (GO:0072009)2.73431588
156plasma lipoprotein particle clearance (GO:0034381)2.72374596
157positive regulation of fatty acid metabolic process (GO:0045923)2.72231271
158protein retention in ER lumen (GO:0006621)2.71806696
159glycogen catabolic process (GO:0005980)2.71530280
160regulation of vasculogenesis (GO:2001212)2.71269151
161cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71242250
162blood vessel morphogenesis (GO:0048514)2.70714539
163positive regulation of glucose transport (GO:0010828)2.70589067
164regulation of sarcomere organization (GO:0060297)2.69362602
165positive regulation of glycogen biosynthetic process (GO:0045725)2.69301326
166heart morphogenesis (GO:0003007)2.68195862
167glomerulus development (GO:0032835)2.68120423
168positive regulation of insulin receptor signaling pathway (GO:0046628)2.67943571
169cardiac right ventricle morphogenesis (GO:0003215)2.67856998
170actin-mediated cell contraction (GO:0070252)2.66812818
171regulation of heart morphogenesis (GO:2000826)2.65913637
172oxygen transport (GO:0015671)2.65447606
173actin filament-based movement (GO:0030048)2.65421810
174ventricular cardiac muscle cell development (GO:0055015)2.64546672
175cardiac septum development (GO:0003279)2.64280796
176cochlea morphogenesis (GO:0090103)2.63941496
177striated muscle cell proliferation (GO:0014855)2.63765405
178acylglycerol biosynthetic process (GO:0046463)2.63538340
179neutral lipid biosynthetic process (GO:0046460)2.63538340
180fatty acid beta-oxidation (GO:0006635)2.62136187
181positive regulation of cholesterol efflux (GO:0010875)2.62066347
182negative regulation of Rho protein signal transduction (GO:0035024)2.60788234
183cell proliferation involved in metanephros development (GO:0072203)2.59963511
184positive regulation of macrophage cytokine production (GO:0060907)2.59962997
185regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.59957051
186primary alcohol metabolic process (GO:0034308)2.59334639
187regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.58664202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.23889992
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.66885175
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.66490758
4CLOCK_20551151_ChIP-Seq_293T_Human3.40694882
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.96149706
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95607150
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.82386494
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.68571060
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.65204660
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60843344
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.60825052
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.60825052
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.57616971
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49217837
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37470719
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24968146
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.23129267
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.22536832
19CJUN_26792858_Chip-Seq_BT549_Human2.13836319
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13111721
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10933838
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01997569
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.96755589
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.96006914
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92472554
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.92137961
27BRD4_25478319_ChIP-Seq_HGPS_Human1.82851470
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82538266
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.78637409
30LXR_22292898_ChIP-Seq_THP-1_Human1.78392321
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78352608
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76941370
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75159314
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74294261
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.72207986
36STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.68126047
37EZH2_22144423_ChIP-Seq_EOC_Human1.66042895
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65753925
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65639569
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.64236592
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.62545643
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59092060
43ZNF263_19887448_ChIP-Seq_K562_Human1.59005008
44KDM2B_26808549_Chip-Seq_DND41_Human1.58594960
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58330699
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58202687
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57977343
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57045580
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53772383
50RACK7_27058665_Chip-Seq_MCF-7_Human1.53564181
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53026284
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52001859
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51643781
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.51445387
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49508160
56CTCF_27219007_Chip-Seq_Bcells_Human1.48343679
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.48305471
58SMC3_22415368_ChIP-Seq_MEFs_Mouse1.47504442
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.47355950
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.41968488
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41832743
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.40465293
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39903305
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39486784
65SMC4_20622854_ChIP-Seq_HELA_Human1.36988828
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35527444
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35527444
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35527444
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.34575219
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.34005990
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33720120
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33386406
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32456029
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32104204
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32104204
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31110636
77VDR_21846776_ChIP-Seq_THP-1_Human1.30957162
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.29824300
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29240419
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.28557902
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.25528356
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.25202816
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25126186
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24330498
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24271837
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.23957112
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22986530
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21525881
89P68_20966046_ChIP-Seq_HELA_Human1.21425758
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20536947
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20536947
92MYC_27129775_Chip-Seq_CORNEA_Mouse1.19353699
93SA1_22415368_ChIP-Seq_MEFs_Mouse1.19147066
94* LXR_22158963_ChIP-Seq_LIVER_Mouse1.18743800
95GATA1_22025678_ChIP-Seq_K562_Human1.17716702
96SOX2_20726797_ChIP-Seq_SW620_Human1.17707032
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17565829
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17027035
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15824021
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.14982866
101BCAT_22108803_ChIP-Seq_LS180_Human1.14931973
102SA1_27219007_Chip-Seq_Bcells_Human1.13761157
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13559942
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13197351
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.13067393
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12805578
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12804772
108* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12795217
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.10333977
110TCF7_22412390_ChIP-Seq_EML_Mouse1.08311402
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07501860
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07185853
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07089031
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06175343
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05797130
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.05279419
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03889780
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02894044
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02527092
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02290719
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01531892
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01443083
123MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01265115
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.01119758
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.00171468
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99705414
127KDM2B_26808549_Chip-Seq_K562_Human0.99633203
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98791958
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98715393
130MAF_26560356_Chip-Seq_TH2_Human0.97671891
131GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97561761
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97155507
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96959264
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.96461363
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96023558
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95481229
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95238925
138* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94674138
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.94627280
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94600791
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94386760
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94065823
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94033172
144EZH2_27294783_Chip-Seq_ESCs_Mouse0.93495195
145RING1B_27294783_Chip-Seq_ESCs_Mouse0.92518984
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92130022
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89613808
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89185893
149SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89074954
150* RING1B_27294783_Chip-Seq_NPCs_Mouse0.88278093
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87395083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.97186366
2MP0008438_abnormal_cutaneous_collagen5.63846211
3MP0005503_abnormal_tendon_morphology5.04328575
4MP0010368_abnormal_lymphatic_system4.73793769
5MP0005666_abnormal_adipose_tissue4.51759151
6MP0004130_abnormal_muscle_cell4.25310014
7MP0005275_abnormal_skin_tensile3.68664304
8MP0002837_dystrophic_cardiac_calcinosis3.57278182
9MP0004272_abnormal_basement_membrane3.52842471
10MP0004185_abnormal_adipocyte_glucose3.49091105
11MP0000751_myopathy3.09190362
12MP0001879_abnormal_lymphatic_vessel2.95251155
13MP0004084_abnormal_cardiac_muscle2.91132967
14* MP0002971_abnormal_brown_adipose2.89616449
15MP0004215_abnormal_myocardial_fiber2.64170093
16MP0001958_emphysema2.54458865
17MP0003705_abnormal_hypodermis_morpholog2.45279082
18MP0003279_aneurysm2.44960643
19MP0000013_abnormal_adipose_tissue2.43420828
20MP0005623_abnormal_meninges_morphology2.34191087
21MP0006054_spinal_hemorrhage2.25595203
22MP0002108_abnormal_muscle_morphology2.17266587
23MP0005330_cardiomyopathy2.17146082
24MP0009115_abnormal_fat_cell2.13152404
25MP0002877_abnormal_melanocyte_morpholog1.89086736
26MP0000749_muscle_degeneration1.85732259
27MP0003959_abnormal_lean_body1.80834348
28MP0004036_abnormal_muscle_relaxation1.78859769
29MP0001661_extended_life_span1.75016406
30MP0002972_abnormal_cardiac_muscle1.74000875
31MP0000003_abnormal_adipose_tissue1.73699607
32MP0006138_congestive_heart_failure1.72540018
33MP0003828_pulmonary_edema1.68247387
34MP0005508_abnormal_skeleton_morphology1.67932514
35MP0000750_abnormal_muscle_regeneration1.65225078
36MP0005385_cardiovascular_system_phenoty1.61554413
37MP0001544_abnormal_cardiovascular_syste1.61554413
38MP0002970_abnormal_white_adipose1.58744597
39MP0002876_abnormal_thyroid_physiology1.58479163
40MP0004087_abnormal_muscle_fiber1.55290993
41MP0010030_abnormal_orbit_morphology1.54647590
42MP0003566_abnormal_cell_adhesion1.54237407
43MP0008775_abnormal_heart_ventricle1.53653718
44MP0010630_abnormal_cardiac_muscle1.48623345
45MP0005334_abnormal_fat_pad1.48205326
46MP0010329_abnormal_lipoprotein_level1.42190676
47MP0005369_muscle_phenotype1.38973343
48MP0002127_abnormal_cardiovascular_syste1.37806256
49MP0000767_abnormal_smooth_muscle1.36949619
50MP0003567_abnormal_fetal_cardiomyocyte1.36193836
51MP0009250_abnormal_appendicular_skeleto1.34561767
52MP0005171_absent_coat_pigmentation1.34385740
53MP0004233_abnormal_muscle_weight1.33983737
54MP0003385_abnormal_body_wall1.33625401
55MP0005620_abnormal_muscle_contractility1.33417673
56MP0009379_abnormal_foot_pigmentation1.31105616
57MP0005535_abnormal_body_temperature1.26742639
58MP0003646_muscle_fatigue1.25514943
59MP0005257_abnormal_intraocular_pressure1.25187235
60MP0002106_abnormal_muscle_physiology1.25118137
61MP0009780_abnormal_chondrocyte_physiolo1.23130492
62MP0000678_abnormal_parathyroid_gland1.22925426
63MP0003724_increased_susceptibility_to1.22807469
64MP0003186_abnormal_redox_activity1.22505325
65MP0004085_abnormal_heartbeat1.21519862
66MP0004145_abnormal_muscle_electrophysio1.19834003
67MP0003122_maternal_imprinting1.17220573
68MP0002128_abnormal_blood_circulation1.14005425
69MP0000266_abnormal_heart_morphology1.13887410
70MP0002938_white_spotting1.13679991
71MP0002060_abnormal_skin_morphology1.13067411
72MP0003137_abnormal_impulse_conducting1.12931192
73MP0003283_abnormal_digestive_organ1.11936750
74MP0002925_abnormal_cardiovascular_devel1.11659755
75MP0002295_abnormal_pulmonary_circulatio1.08972127
76MP0004484_altered_response_of1.05288842
77MP0005375_adipose_tissue_phenotype1.03250581
78MP0002896_abnormal_bone_mineralization1.02118235
79MP0001299_abnormal_eye_distance/1.01302509
80MP0006036_abnormal_mitochondrial_physio1.00594246
81MP0002269_muscular_atrophy0.97769067
82* MP0000759_abnormal_skeletal_muscle0.96861893
83MP0005167_abnormal_blood-brain_barrier0.95462695
84MP0002118_abnormal_lipid_homeostasis0.94722460
85MP0005448_abnormal_energy_balance0.94208571
86MP0000049_abnormal_middle_ear0.93699815
87* MP0002932_abnormal_joint_morphology0.91912281
88MP0000534_abnormal_ureter_morphology0.89619486
89MP0003935_abnormal_craniofacial_develop0.86711409
90MP0005083_abnormal_biliary_tract0.86224952
91MP0001614_abnormal_blood_vessel0.85304834
92MP0002249_abnormal_larynx_morphology0.84385191
93MP0003115_abnormal_respiratory_system0.83818280
94* MP0000733_abnormal_muscle_development0.83795407
95MP0003011_delayed_dark_adaptation0.83446807
96* MP0005452_abnormal_adipose_tissue0.81966620
97MP0000163_abnormal_cartilage_morphology0.81575709
98MP0004134_abnormal_chest_morphology0.79424785
99MP0008789_abnormal_olfactory_epithelium0.79234884
100* MP0003948_abnormal_gas_homeostasis0.79081414
101MP0001177_atelectasis0.78295059
102MP0000343_altered_response_to0.77783302
103MP0003119_abnormal_digestive_system0.77729221
104MP0005409_darkened_coat_color0.76933357
105MP0000747_muscle_weakness0.76314995
106MP0000249_abnormal_blood_vessel0.75997349
107MP0010386_abnormal_urinary_bladder0.75709317
108MP0001346_abnormal_lacrimal_gland0.75440545
109MP0003941_abnormal_skin_development0.74979504
110MP0002638_abnormal_pupillary_reflex0.74431731
111MP0002282_abnormal_trachea_morphology0.74008952
112MP0005220_abnormal_exocrine_pancreas0.71750558
113MP0002133_abnormal_respiratory_system0.70862756
114MP0005388_respiratory_system_phenotype0.70862756
115MP0003252_abnormal_bile_duct0.67212566
116MP0003690_abnormal_glial_cell0.66680950
117MP0000516_abnormal_urinary_system0.66588008
118MP0005367_renal/urinary_system_phenotyp0.66588008
119MP0005390_skeleton_phenotype0.66402215
120MP0002396_abnormal_hematopoietic_system0.66175678
121MP0002078_abnormal_glucose_homeostasis0.64905951
122MP0002138_abnormal_hepatobiliary_system0.64570955
123MP0009384_cardiac_valve_regurgitation0.64531139
124MP0005595_abnormal_vascular_smooth0.64090217
125MP0001784_abnormal_fluid_regulation0.64076730
126MP0002933_joint_inflammation0.63889988
127MP0009053_abnormal_anal_canal0.63837041
128MP0001175_abnormal_lung_morphology0.62542337
129MP0000858_altered_metastatic_potential0.62250717
130MP0001944_abnormal_pancreas_morphology0.62127519
131MP0002796_impaired_skin_barrier0.61435199
132MP0000230_abnormal_systemic_arterial0.61155135
133MP0002115_abnormal_skeleton_extremities0.60835085
134MP0003300_gastrointestinal_ulcer0.60818374
135MP0003191_abnormal_cellular_cholesterol0.60213435
136MP0002909_abnormal_adrenal_gland0.60212523
137MP0002009_preneoplasia0.60140037
138MP0003221_abnormal_cardiomyocyte_apopto0.59966551
139MP0000762_abnormal_tongue_morphology0.59380468
140MP0004858_abnormal_nervous_system0.58502110

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.83358890
2Oligomenorrhea (HP:0000876)5.31424613
3Premature rupture of membranes (HP:0001788)5.13563679
4Calcaneovalgus deformity (HP:0001848)4.96409032
5Broad metatarsal (HP:0001783)4.76452778
6Deformed tarsal bones (HP:0008119)4.30913087
7Acanthosis nigricans (HP:0000956)4.28463901
8Sudden death (HP:0001699)4.18417461
9Increased connective tissue (HP:0009025)4.08134782
10Hypertriglyceridemia (HP:0002155)3.86775823
11Atrioventricular block (HP:0001678)3.81253247
12Ventricular tachycardia (HP:0004756)3.77142249
13Muscle fiber inclusion bodies (HP:0100299)3.75025902
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.68110561
15Muscle fiber splitting (HP:0003555)3.67197910
16Nemaline bodies (HP:0003798)3.60375986
17Lipoatrophy (HP:0100578)3.54519772
18Atrial fibrillation (HP:0005110)3.45979274
19Hyperinsulinemic hypoglycemia (HP:0000825)3.44466788
20Soft skin (HP:0000977)3.36385931
21Shallow orbits (HP:0000586)3.31722918
22Abnormality of the left ventricular outflow tract (HP:0011103)3.30638151
23Subaortic stenosis (HP:0001682)3.30638151
24Abnormality of the calf musculature (HP:0001430)3.30368427
25Pulmonary artery stenosis (HP:0004415)3.27759313
26Abnormality of the calcaneus (HP:0008364)3.27391821
27Cerebral aneurysm (HP:0004944)3.18566617
28Primary atrial arrhythmia (HP:0001692)3.16439514
29Hyperglycemia (HP:0003074)3.15661700
30Patent foramen ovale (HP:0001655)3.14692931
31Supraventricular arrhythmia (HP:0005115)3.13527623
32Hypoglycemic coma (HP:0001325)3.09520101
33Heart block (HP:0012722)3.07359781
34Bladder diverticulum (HP:0000015)3.07190871
35Right ventricular cardiomyopathy (HP:0011663)3.04937075
36Aortic dissection (HP:0002647)3.03844636
37Calf muscle hypertrophy (HP:0008981)3.03083474
38Neck muscle weakness (HP:0000467)3.02637398
39Supraventricular tachycardia (HP:0004755)2.99706510
40Fragile skin (HP:0001030)2.95450666
41Rectal prolapse (HP:0002035)2.92699419
42Vascular tortuosity (HP:0004948)2.89807843
43Spinal rigidity (HP:0003306)2.89286467
44Round ear (HP:0100830)2.86140693
45Distal arthrogryposis (HP:0005684)2.85907031
46Mitral stenosis (HP:0001718)2.84565530
47Hypoglycemic seizures (HP:0002173)2.81940804
48Ankle contracture (HP:0006466)2.81351284
49Muscle stiffness (HP:0003552)2.75105081
50Distal lower limb muscle weakness (HP:0009053)2.73546841
51Dilated cardiomyopathy (HP:0001644)2.72167546
52Rhabdomyolysis (HP:0003201)2.71332413
53Hyporeflexia of lower limbs (HP:0002600)2.70970607
54Exercise-induced muscle cramps (HP:0003710)2.69857533
55Arterial tortuosity (HP:0005116)2.66017712
56Syringomyelia (HP:0003396)2.65581342
57Spinal cord lesions (HP:0100561)2.65581342
58Infantile muscular hypotonia (HP:0008947)2.65563532
59Bulbar palsy (HP:0001283)2.62220682
60Prolonged QT interval (HP:0001657)2.61028858
61Thin bony cortex (HP:0002753)2.59406425
62Muscle hypertrophy of the lower extremities (HP:0008968)2.57696788
63Ectopia lentis (HP:0001083)2.57651959
64Aneurysm (HP:0002617)2.56096832
65Ulnar deviation of the wrist (HP:0003049)2.55271732
66Mildly elevated creatine phosphokinase (HP:0008180)2.54191674
67Type 1 muscle fiber predominance (HP:0003803)2.52613370
68Asymmetric septal hypertrophy (HP:0001670)2.52309025
69Wrist flexion contracture (HP:0001239)2.51608426
70Colitis (HP:0002583)2.49515605
71Dilatation of the ascending aorta (HP:0005111)2.47591461
72Pancreatic islet-cell hyperplasia (HP:0004510)2.47491849
73Gowers sign (HP:0003391)2.47016244
74Aortic aneurysm (HP:0004942)2.44908193
75Hyperextensible skin (HP:0000974)2.42705966
76EMG: myopathic abnormalities (HP:0003458)2.42464108
77Overgrowth (HP:0001548)2.41776784
78Rimmed vacuoles (HP:0003805)2.40287018
79Lymphangioma (HP:0100764)2.39227277
80Increased muscle lipid content (HP:0009058)2.39161096
81Myopathic facies (HP:0002058)2.38364909
82Mitral valve prolapse (HP:0001634)2.37387906
83Peritonitis (HP:0002586)2.37097932
84Striae distensae (HP:0001065)2.36252941
85Symptomatic seizures (HP:0011145)2.34354156
86Flat cornea (HP:0007720)2.33581786
87Increased variability in muscle fiber diameter (HP:0003557)2.31364600
88Insulin resistance (HP:0000855)2.30439365
89Renal duplication (HP:0000075)2.28019974
90Hypercortisolism (HP:0001578)2.27601939
91Bundle branch block (HP:0011710)2.26881996
92Spondylolisthesis (HP:0003302)2.26628432
93Subacute progressive viral hepatitis (HP:0006572)2.25691132
94Lip pit (HP:0100267)2.23992082
95Hemorrhage of the eye (HP:0011885)2.23830099
96Exercise-induced myalgia (HP:0003738)2.23273620
97Mitral regurgitation (HP:0001653)2.21409451
98Broad ribs (HP:0000885)2.20719595
99Back pain (HP:0003418)2.17467876
100Joint laxity (HP:0001388)2.17253602
101Centrally nucleated skeletal muscle fibers (HP:0003687)2.16785990
102Blue sclerae (HP:0000592)2.14397673
103Camptodactyly of toe (HP:0001836)2.14070041
104Myoglobinuria (HP:0002913)2.13625886
105Hematochezia (HP:0002573)2.12671873
106Abnormality of the tricuspid valve (HP:0001702)2.11045216
107Frequent falls (HP:0002359)2.10327238
108Reduced subcutaneous adipose tissue (HP:0003758)2.09977682
109Large for gestational age (HP:0001520)2.07972129
110Hyperlipoproteinemia (HP:0010980)2.07558034
111Hepatoblastoma (HP:0002884)2.06928882
112Metaphyseal cupping (HP:0003021)2.06530902
113Ketoacidosis (HP:0001993)2.06518761
114Thin ribs (HP:0000883)2.05357151
115Venous insufficiency (HP:0005293)2.04054723
116Abnormal pancreas size (HP:0012094)2.02721584
117Abnormality of skeletal muscle fiber size (HP:0012084)2.02374116
118Scapular winging (HP:0003691)2.01229061
119Malignant hyperthermia (HP:0002047)1.98013625
120Insulin-resistant diabetes mellitus (HP:0000831)1.97833838
121Atrophic scars (HP:0001075)1.97666666
122Abnormality of the 4th metacarpal (HP:0010012)1.97391421
123Polycythemia (HP:0001901)1.97125374
124Venous abnormality (HP:0002624)1.96478615
125Syncope (HP:0001279)1.96383229
126Easy fatigability (HP:0003388)1.96202278
127Difficulty climbing stairs (HP:0003551)1.96131678
128Areflexia of lower limbs (HP:0002522)1.93666072
129Popliteal pterygium (HP:0009756)1.93431089
130Cervical subluxation (HP:0003308)1.93363883
131Ventricular arrhythmia (HP:0004308)1.92543145
132Abnormality of complement system (HP:0005339)1.91956467
133Hypoplasia of the iris (HP:0007676)1.91054632
134Metatarsus adductus (HP:0001840)1.90443383
135Annular pancreas (HP:0001734)1.90086428
136Aortic valve stenosis (HP:0001650)1.89279113
137Abnormal atrioventricular conduction (HP:0005150)1.87777864
138Short 4th metacarpal (HP:0010044)1.86847255
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86847255
140Abnormality of dentin (HP:0010299)1.84894426
141Follicular hyperkeratosis (HP:0007502)1.83233570
142Abnormality of endocrine pancreas physiology (HP:0012093)1.82028934
143Abnormality of the pancreatic islet cells (HP:0006476)1.82028934
144Palpitations (HP:0001962)1.80414334
145Vertebral compression fractures (HP:0002953)1.80250788
146Difficulty running (HP:0009046)1.78542583
147Limb-girdle muscle atrophy (HP:0003797)1.77172994
148Disproportionate tall stature (HP:0001519)1.76573938
149Limited hip movement (HP:0008800)1.76075030
150Myotonia (HP:0002486)1.75810711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.98270490
2RIPK13.92045450
3PDGFRA3.25239079
4TTN3.18867939
5STK38L2.77566332
6DMPK2.62672879
7TRPM72.61273588
8KDR2.59592395
9EEF2K2.47445417
10TGFBR22.47341293
11LATS12.44983849
12STK242.41288898
13MARK22.37522385
14TRIB32.35556570
15TGFBR12.35469115
16MYLK2.01281840
17INSRR1.97178351
18PTK61.92841632
19PASK1.82870398
20PRKD31.79652616
21ERBB31.78450749
22MAPK151.74488825
23LATS21.65626193
24MAPK121.64033148
25MAP3K61.57515861
26MOS1.50801034
27WNK41.47698712
28CAMK11.41656303
29PRPF4B1.35852108
30OBSCN1.34635162
31MAP3K71.31815606
32LMTK21.31565618
33FER1.30721700
34PHKG21.30669185
35PHKG11.30669185
36PTK21.28685180
37EPHB21.27927924
38STK31.24353838
39BCKDK1.23408485
40ILK1.22127036
41PTK2B1.21673005
42PRKD11.17356691
43ERN11.15302535
44MAPKAPK31.15071823
45PKN21.14524737
46MET1.12873203
47PDK41.11848646
48PDK31.11848646
49NEK91.10417915
50PDK21.09165168
51TYK21.08873560
52JAK31.08861579
53MAPK41.08837234
54PAK31.07659085
55PRKCH1.06541257
56CSK1.05442873
57TAOK11.04655207
58CDC42BPA1.01730030
59PDGFRB0.99666799
60MAP3K100.96457184
61GRK50.96410978
62ARAF0.94798397
63CDK60.92779504
64MAP3K30.92667157
65WNK10.87083799
66PAK20.85272284
67ZAK0.84799354
68TESK10.84064512
69DDR20.83947725
70CDK40.83739151
71MAP2K10.82613659
72MAP3K130.82248851
73PIK3CA0.81500815
74ZAP700.80256450
75HIPK20.79807195
76PAK40.79640340
77MTOR0.75832657
78PDPK10.75497966
79EPHB10.74482854
80TBK10.68507529
81KSR20.66141453
82ROCK10.66023453
83PRKD20.63943507
84RET0.63002277
85NLK0.61561917
86FGFR30.60786656
87PRKCE0.59932992
88PIK3CG0.59545015
89FRK0.57732730
90FGFR10.55994209
91MAP2K20.55876854
92ABL20.55240517
93STK110.55215418
94EPHA30.54035513
95GSK3A0.53977382
96CDK90.53932103
97MAPK70.53886645
98PRKACG0.51873541
99BCR0.51254242
100IRAK10.49937693
101FES0.49903989
102RPS6KA60.49572508
103STK380.48576515
104FLT30.47964936
105CAMK2D0.47070868
106PLK20.46655588
107MKNK20.46423304
108MUSK0.46112398
109MAP3K10.45425799
110CAMK1D0.45274096
111SIK10.45196171
112MAPK110.45031783
113PRKG10.44658642
114FGFR40.43360707
115NUAK10.43288719
116TSSK60.43046522
117SMG10.41832775
118IGF1R0.40250927
119MAPK30.39717702
120JAK20.38990024
121MARK30.38894323
122MKNK10.38811147
123DYRK1B0.38719360
124CAMK1G0.38411719
125ICK0.38334884
126PRKAA20.38163970
127CAMK40.38125779
128TYRO30.37511033
129RPS6KB20.36711352
130MELK0.36347369
131AKT20.35895181
132BLK0.34738873
133PRKAA10.34607801
134BMPR1B0.33403048
135PLK30.32857985
136PINK10.32053095
137LRRK20.31462637
138RPS6KL10.31449407
139RPS6KC10.31449407
140HCK0.30263044
141MAP3K20.30250337
142MAP2K30.29813919
143FGFR20.29709672
144RPS6KA20.28411383
145BMX0.27918100
146DAPK30.26189663
147PRKACB0.25951026
148JAK10.25717457
149ADRBK10.25170752

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.85440981
2Dilated cardiomyopathy_Homo sapiens_hsa054143.47283926
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.39781091
4Phenylalanine metabolism_Homo sapiens_hsa003603.16769276
5ECM-receptor interaction_Homo sapiens_hsa045123.14124172
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90814796
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.69946138
8Glycerolipid metabolism_Homo sapiens_hsa005612.49845950
9Focal adhesion_Homo sapiens_hsa045102.43174537
10Pyruvate metabolism_Homo sapiens_hsa006202.25738539
11Adherens junction_Homo sapiens_hsa045202.08727441
12Protein export_Homo sapiens_hsa030602.03467377
13Viral myocarditis_Homo sapiens_hsa054161.88143367
14Protein digestion and absorption_Homo sapiens_hsa049741.86713802
15Histidine metabolism_Homo sapiens_hsa003401.82347894
16Insulin resistance_Homo sapiens_hsa049311.81850581
17Cardiac muscle contraction_Homo sapiens_hsa042601.65547325
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64981018
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61492000
20Malaria_Homo sapiens_hsa051441.60849025
21beta-Alanine metabolism_Homo sapiens_hsa004101.57498585
22Tyrosine metabolism_Homo sapiens_hsa003501.57393934
23Fatty acid elongation_Homo sapiens_hsa000621.55849895
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51786715
25Proteoglycans in cancer_Homo sapiens_hsa052051.44891344
26Insulin secretion_Homo sapiens_hsa049111.42207415
27Amoebiasis_Homo sapiens_hsa051461.41833792
28Sulfur relay system_Homo sapiens_hsa041221.39462070
29Fat digestion and absorption_Homo sapiens_hsa049751.30898943
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28184010
31Fatty acid degradation_Homo sapiens_hsa000711.27734930
32TGF-beta signaling pathway_Homo sapiens_hsa043501.27418472
33Glucagon signaling pathway_Homo sapiens_hsa049221.25126968
34Tight junction_Homo sapiens_hsa045301.20094192
35Notch signaling pathway_Homo sapiens_hsa043301.19434317
36Lysine degradation_Homo sapiens_hsa003101.19373004
37Hippo signaling pathway_Homo sapiens_hsa043901.18982812
38Small cell lung cancer_Homo sapiens_hsa052221.18484675
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17566026
40Type II diabetes mellitus_Homo sapiens_hsa049301.17534846
41Basal cell carcinoma_Homo sapiens_hsa052171.16640431
42Dorso-ventral axis formation_Homo sapiens_hsa043201.13517600
43Starch and sucrose metabolism_Homo sapiens_hsa005001.10752488
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09416938
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09215602
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06369329
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04119617
48Carbon metabolism_Homo sapiens_hsa012001.00630767
49MicroRNAs in cancer_Homo sapiens_hsa052061.00592975
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00448484
51Ovarian steroidogenesis_Homo sapiens_hsa049130.99824630
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97638654
53Fatty acid biosynthesis_Homo sapiens_hsa000610.97073305
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92951713
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89128993
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88846698
57Estrogen signaling pathway_Homo sapiens_hsa049150.87305259
58Hedgehog signaling pathway_Homo sapiens_hsa043400.86911443
59Acute myeloid leukemia_Homo sapiens_hsa052210.86670493
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.84798453
61Thyroid hormone synthesis_Homo sapiens_hsa049180.83507368
62Pathways in cancer_Homo sapiens_hsa052000.82403899
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80859005
64Prostate cancer_Homo sapiens_hsa052150.79918771
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.79856441
66Insulin signaling pathway_Homo sapiens_hsa049100.79783763
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78826470
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78644768
69Galactose metabolism_Homo sapiens_hsa000520.77748807
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.77556900
71Sulfur metabolism_Homo sapiens_hsa009200.76338332
72Propanoate metabolism_Homo sapiens_hsa006400.74639404
73Circadian rhythm_Homo sapiens_hsa047100.74069756
74Chronic myeloid leukemia_Homo sapiens_hsa052200.73306415
75Rap1 signaling pathway_Homo sapiens_hsa040150.73100238
76Vibrio cholerae infection_Homo sapiens_hsa051100.72484162
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72019199
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71846426
79Wnt signaling pathway_Homo sapiens_hsa043100.71766813
80Arginine biosynthesis_Homo sapiens_hsa002200.71498941
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.70041636
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69437069
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67716965
84Melanogenesis_Homo sapiens_hsa049160.66947890
85Prion diseases_Homo sapiens_hsa050200.66858643
86Toxoplasmosis_Homo sapiens_hsa051450.65781956
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.65501939
88Fatty acid metabolism_Homo sapiens_hsa012120.64493730
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63057146
90AMPK signaling pathway_Homo sapiens_hsa041520.59571263
91HTLV-I infection_Homo sapiens_hsa051660.59478532
92Thyroid cancer_Homo sapiens_hsa052160.58536216
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57180397
94Renal cell carcinoma_Homo sapiens_hsa052110.56514219
95Gap junction_Homo sapiens_hsa045400.56076399
96Renin-angiotensin system_Homo sapiens_hsa046140.55613294
97Parkinsons disease_Homo sapiens_hsa050120.55241462
98Renin secretion_Homo sapiens_hsa049240.55009623
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54835158
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.54193448
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53011853
102Cocaine addiction_Homo sapiens_hsa050300.52461618
103FoxO signaling pathway_Homo sapiens_hsa040680.52247458
104Platelet activation_Homo sapiens_hsa046110.52228708
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.51861360
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51847158
107Axon guidance_Homo sapiens_hsa043600.51416712
108cAMP signaling pathway_Homo sapiens_hsa040240.50188999
109Melanoma_Homo sapiens_hsa052180.49547577
110Ras signaling pathway_Homo sapiens_hsa040140.49129279
111VEGF signaling pathway_Homo sapiens_hsa043700.49101075
112PPAR signaling pathway_Homo sapiens_hsa033200.48279939
113Oxytocin signaling pathway_Homo sapiens_hsa049210.47926049
114HIF-1 signaling pathway_Homo sapiens_hsa040660.47166401
115Bladder cancer_Homo sapiens_hsa052190.46810336
116TNF signaling pathway_Homo sapiens_hsa046680.46700230
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.46673076
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46192892
119Pancreatic cancer_Homo sapiens_hsa052120.45691929
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42190135
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41944277
122Ribosome_Homo sapiens_hsa030100.41598145
123GnRH signaling pathway_Homo sapiens_hsa049120.41485713
124Arginine and proline metabolism_Homo sapiens_hsa003300.40607513
125Tryptophan metabolism_Homo sapiens_hsa003800.39764188
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38378797
127Staphylococcus aureus infection_Homo sapiens_hsa051500.36580793
128Colorectal cancer_Homo sapiens_hsa052100.35133866
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34091202
130Fructose and mannose metabolism_Homo sapiens_hsa000510.32545848
131Chemokine signaling pathway_Homo sapiens_hsa040620.29759203
132Biosynthesis of amino acids_Homo sapiens_hsa012300.27898154

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