MEOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myoblast migration (GO:0051451)8.22115731
2generation of neurons (GO:0048699)8.08261885
3peripheral nervous system neuron development (GO:0048935)6.96708334
4organ induction (GO:0001759)5.86602072
5proximal/distal pattern formation (GO:0009954)5.74709520
6regulation of cardioblast proliferation (GO:0003264)5.47822704
7regulation of secondary heart field cardioblast proliferation (GO:0003266)5.47822704
8cranial nerve morphogenesis (GO:0021602)5.38154964
9planar cell polarity pathway involved in neural tube closure (GO:0090179)5.33120840
10regulation of transforming growth factor beta2 production (GO:0032909)5.19615616
11cardiac myofibril assembly (GO:0055003)5.11319348
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.98154925
13glomerular filtration (GO:0003094)4.97053700
14G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.94020052
15lymph vessel development (GO:0001945)4.86612725
16endothelial cell morphogenesis (GO:0001886)4.78540234
17muscle cell migration (GO:0014812)4.74935924
18sarcomere organization (GO:0045214)4.65733969
19plasma membrane repair (GO:0001778)4.61752304
20retina vasculature morphogenesis in camera-type eye (GO:0061299)4.46441682
21myofibril assembly (GO:0030239)4.43224924
22renal filtration (GO:0097205)4.37906650
23embryonic skeletal joint morphogenesis (GO:0060272)4.30315363
24vascular endothelial growth factor signaling pathway (GO:0038084)4.19135228
25actin-myosin filament sliding (GO:0033275)4.18057811
26muscle filament sliding (GO:0030049)4.18057811
27embryonic skeletal system morphogenesis (GO:0048704)4.14555080
28middle ear morphogenesis (GO:0042474)4.14456310
29aorta morphogenesis (GO:0035909)4.12978636
30nephron tubule formation (GO:0072079)4.12632794
31blood vessel maturation (GO:0001955)4.11926754
32regulation of heart morphogenesis (GO:2000826)4.10680066
33extracellular fibril organization (GO:0043206)4.07221213
34protein heterotrimerization (GO:0070208)4.06883767
35positive regulation of odontogenesis (GO:0042482)4.03111994
36heart trabecula formation (GO:0060347)3.96527034
37* skeletal muscle tissue development (GO:0007519)3.95206976
38thyroid gland development (GO:0030878)3.94162157
39negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.94098307
40artery smooth muscle contraction (GO:0014824)3.93648014
41positive regulation of embryonic development (GO:0040019)3.90498278
42collagen fibril organization (GO:0030199)3.89225484
43regulation of endothelial cell differentiation (GO:0045601)3.87186423
44cell migration involved in heart development (GO:0060973)3.84258159
45negative regulation of kidney development (GO:0090185)3.83962281
46fibril organization (GO:0097435)3.81501183
47forelimb morphogenesis (GO:0035136)3.80428417
48neuron fate specification (GO:0048665)3.79123968
49cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.74842682
50tonic smooth muscle contraction (GO:0014820)3.74316748
51positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.72997273
52neuron projection extension involved in neuron projection guidance (GO:1902284)3.72910100
53axon extension involved in axon guidance (GO:0048846)3.72910100
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69135714
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66894534
56regulation of organ formation (GO:0003156)3.65807611
57embryonic digestive tract development (GO:0048566)3.60748068
58actin-mediated cell contraction (GO:0070252)3.60465958
59regulation of skeletal muscle contraction (GO:0014819)3.59390310
60embryonic cranial skeleton morphogenesis (GO:0048701)3.58777398
61trabecula formation (GO:0060343)3.57507098
62head development (GO:0060322)3.57352993
63positive regulation of vesicle fusion (GO:0031340)3.57031131
64muscle cell proliferation (GO:0033002)3.56434829
65cochlea morphogenesis (GO:0090103)3.56115151
66Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.56021076
67regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.55615023
68extracellular matrix assembly (GO:0085029)3.54930410
69developmental induction (GO:0031128)3.54681997
70skeletal system morphogenesis (GO:0048705)3.52289648
71outflow tract morphogenesis (GO:0003151)3.49594600
72positive regulation of gastrulation (GO:2000543)3.46420571
73negative regulation of embryonic development (GO:0045992)3.45620126
74negative regulation of striated muscle cell apoptotic process (GO:0010664)3.43371369
75regulation of establishment of planar polarity (GO:0090175)3.42437466
76non-canonical Wnt signaling pathway (GO:0035567)3.41782541
77neurogenesis (GO:0022008)3.41529532
78bone trabecula formation (GO:0060346)3.41475850
79negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.41390588
80mesenchymal cell differentiation involved in kidney development (GO:0072161)3.38708582
81mesenchymal cell differentiation involved in renal system development (GO:2001012)3.38708582
82embryonic forelimb morphogenesis (GO:0035115)3.38322304
83basement membrane organization (GO:0071711)3.36645758
84cell-cell signaling involved in cell fate commitment (GO:0045168)3.36587058
85negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35887684
86regulation of tight junction assembly (GO:2000810)3.34551333
87actomyosin structure organization (GO:0031032)3.33962622
88somite development (GO:0061053)3.33161514
89cardiac muscle cell development (GO:0055013)3.29185681
90* striated muscle tissue development (GO:0014706)3.27607987
91metanephric mesenchyme development (GO:0072075)3.26700432
92paraxial mesoderm development (GO:0048339)3.26626350
93* muscle tissue development (GO:0060537)3.25743132
94phagocytosis, recognition (GO:0006910)3.23975645
95cell proliferation involved in metanephros development (GO:0072203)3.23075565
96cardiac muscle cell proliferation (GO:0060038)3.21326582
97fatty acid transmembrane transport (GO:1902001)3.21215447
98embryonic skeletal system development (GO:0048706)3.20940104
99positive regulation of vasculogenesis (GO:2001214)3.20862165
100embryonic organ morphogenesis (GO:0048562)3.20131878
101enteric nervous system development (GO:0048484)3.19745630
102cardiac cell development (GO:0055006)3.19296310
103positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.18272821
104regulation of relaxation of muscle (GO:1901077)3.17760415
105cell differentiation involved in metanephros development (GO:0072202)3.17144684
106hindlimb morphogenesis (GO:0035137)3.13247728
107regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13244852
108pharyngeal system development (GO:0060037)3.10416158
109axis elongation (GO:0003401)3.09719831
110regulation of actin filament-based movement (GO:1903115)3.09214999
111positive regulation of macrophage cytokine production (GO:0060907)3.09093449
112chondrocyte proliferation (GO:0035988)3.08699747
113endothelium development (GO:0003158)3.08618786
114mesenchyme development (GO:0060485)3.08592391
115regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.08389527
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.08113361
117keratan sulfate catabolic process (GO:0042340)3.04837842
118metanephric nephron tubule development (GO:0072234)3.03546640
119metanephric tubule development (GO:0072170)3.03546640
120kidney mesenchyme development (GO:0072074)3.03327361
121negative regulation of BMP signaling pathway (GO:0030514)3.03057777
122regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.01936643
123patterning of blood vessels (GO:0001569)3.01753519
124sequestering of extracellular ligand from receptor (GO:0035581)3.00687814
125* segment specification (GO:0007379)3.00431965
126peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.00216389
127positive regulation of chondrocyte differentiation (GO:0032332)2.99214482
128negative regulation of potassium ion transmembrane transport (GO:1901380)2.98224596
129regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.98016916
130smooth muscle cell differentiation (GO:0051145)2.97959482
131vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96290853
132positive regulation of mesonephros development (GO:0061213)2.95762233
133negative regulation of chondrocyte differentiation (GO:0032331)2.95457849
134cardiac muscle tissue morphogenesis (GO:0055008)2.93500724
135regulation of striated muscle cell apoptotic process (GO:0010662)2.93463798
136cell migration involved in sprouting angiogenesis (GO:0002042)2.93307931
137ganglion development (GO:0061548)2.93205061
138axon extension (GO:0048675)2.92990881
139cardiac muscle contraction (GO:0060048)2.92967133
140lymphangiogenesis (GO:0001946)2.91400131
141regulation of macrophage cytokine production (GO:0010935)2.91350092
142regulation of sequestering of triglyceride (GO:0010889)2.90818439
143branch elongation of an epithelium (GO:0060602)2.90327430
144ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.90058435
145metanephric nephron epithelium development (GO:0072243)2.89983728
146morphogenesis of an endothelium (GO:0003159)2.88962669
147endothelial tube morphogenesis (GO:0061154)2.88962669
148vasculogenesis (GO:0001570)2.88823668
149actin filament-based movement (GO:0030048)2.88685456
150negative regulation of cell fate specification (GO:0009996)2.87339765
151tricarboxylic acid cycle (GO:0006099)2.84100666
152gland morphogenesis (GO:0022612)2.84050452
153regulation of catenin import into nucleus (GO:0035412)2.83785221
154negative regulation of catenin import into nucleus (GO:0035414)2.83642473
155negative regulation of Rho protein signal transduction (GO:0035024)2.83402920
156regulation of embryonic development (GO:0045995)2.82683597
157heart morphogenesis (GO:0003007)2.79077079
158positive regulation of fatty acid oxidation (GO:0046321)2.77495385
159muscle tissue morphogenesis (GO:0060415)2.76021671
160cell proliferation involved in kidney development (GO:0072111)2.75744218
161regulation of cardiac muscle cell apoptotic process (GO:0010665)2.75539554
162regulation of vasculogenesis (GO:2001212)2.74539933
163cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.72903548
164negative regulation of endothelial cell proliferation (GO:0001937)2.72781561
165substrate-dependent cell migration (GO:0006929)2.72440961
166carnitine shuttle (GO:0006853)2.70473919
167collagen metabolic process (GO:0032963)2.69893835
168low-density lipoprotein particle clearance (GO:0034383)2.68983839
169regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.68919047
170outer ear morphogenesis (GO:0042473)2.68439029
171endocardial cushion morphogenesis (GO:0003203)2.68151803
172mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.66957993
173venous blood vessel morphogenesis (GO:0048845)2.66087392
174endothelial cell proliferation (GO:0001935)2.65971183
175glomerular basement membrane development (GO:0032836)2.65821271
176hippo signaling (GO:0035329)2.63763360
177mesenchyme morphogenesis (GO:0072132)2.63402475
178striated muscle hypertrophy (GO:0014897)2.61888431
179positive regulation of cartilage development (GO:0061036)2.61429839
180positive regulation of glycogen biosynthetic process (GO:0045725)2.60889969
181regulation of cardioblast differentiation (GO:0051890)2.59081490
182regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.58856508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.17718378
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.82587877
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.48114946
4EZH2_22144423_ChIP-Seq_EOC_Human4.27154718
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.93266613
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.93266613
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.93266613
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.45221723
9EP300_21415370_ChIP-Seq_HL-1_Mouse3.45201134
10CLOCK_20551151_ChIP-Seq_293T_Human3.37996025
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.04291448
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.82327162
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.67747920
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.67020012
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65998858
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.60879457
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.50409747
18GATA1_22025678_ChIP-Seq_K562_Human2.46414434
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.45434840
20TBX20_22328084_ChIP-Seq_HEART_Mouse2.44099344
21TBX20_22080862_ChIP-Seq_HEART_Mouse2.44099344
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38069625
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28645153
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.26990391
25CJUN_26792858_Chip-Seq_BT549_Human2.25826963
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23431270
27GATA2_21666600_ChIP-Seq_HMVEC_Human2.10987902
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.08594168
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07487991
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97333728
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.95381635
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93760069
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87530933
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.87388571
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87357165
36RING1B_27294783_Chip-Seq_NPCs_Mouse1.86384257
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.86035012
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84808234
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81521103
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81396718
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79544413
42* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79460437
43* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79460437
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76639709
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.75806602
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.69065628
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.67918926
48MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.67505032
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67087062
50* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66313126
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62757139
52BRD4_25478319_ChIP-Seq_HGPS_Human1.62576168
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.61135583
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57967357
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.56681185
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.52198666
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51077906
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.51071779
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50737186
60STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.50516743
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50059119
62* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47903788
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.46590779
64* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45151331
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39135175
66* TP53_20018659_ChIP-ChIP_R1E_Mouse1.36681258
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36307881
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36307881
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34633935
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34598788
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32124917
72* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32019019
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30564047
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29957187
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.28371107
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26196473
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25010522
78* FUS_26573619_Chip-Seq_HEK293_Human1.24304161
79GATA4_21415370_ChIP-Seq_HL-1_Mouse1.22793309
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21003620
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18652642
82AR_21572438_ChIP-Seq_LNCaP_Human1.17996632
83* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17912016
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16752785
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16207613
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15723382
87* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15554109
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13930307
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13147725
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12967729
91RNF2_27304074_Chip-Seq_NSC_Mouse1.10919048
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10498693
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09776684
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08895569
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07452629
96* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07411918
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07071721
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06692893
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06692893
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.06089937
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05533908
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05277761
103SOX2_20726797_ChIP-Seq_SW620_Human1.04513390
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03114738
105TP53_18474530_ChIP-ChIP_U2OS_Human1.02612996
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02493583
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01068603
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00095543
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99720566
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99051662
111TCF4_18268006_ChIP-ChIP_LS174T_Human0.98665768
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98074302
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97939565
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.97910628
115* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97780886
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97645159
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.97186382
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96963512
119DROSHA_22980978_ChIP-Seq_HELA_Human0.96405684
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95716178
121SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95559982
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.95557576
123NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95153944
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94232984
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92066258
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91721742
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91574916
128SA1_22415368_ChIP-Seq_MEFs_Mouse0.90745437
129* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89846784
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89844313
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89304214
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89152969
133* RING1B_27294783_Chip-Seq_ESCs_Mouse0.88195015
134GBX2_23144817_ChIP-Seq_PC3_Human0.84658609
135KDM2B_26808549_Chip-Seq_REH_Human0.84306521
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82229023
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81356191
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.80909095
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77845592
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77449263
141* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76519709
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76498233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.83436384
2MP0005503_abnormal_tendon_morphology4.36786464
3MP0002837_dystrophic_cardiac_calcinosis3.43008902
4MP0010368_abnormal_lymphatic_system3.38081099
5MP0004272_abnormal_basement_membrane3.31627195
6MP0000751_myopathy3.30615195
7MP0005275_abnormal_skin_tensile3.29934714
8MP0004084_abnormal_cardiac_muscle2.98570956
9MP0001879_abnormal_lymphatic_vessel2.95624713
10MP0003705_abnormal_hypodermis_morpholog2.82592135
11MP0001346_abnormal_lacrimal_gland2.67187171
12MP0004215_abnormal_myocardial_fiber2.59841254
13MP0003279_aneurysm2.51421488
14MP0008789_abnormal_olfactory_epithelium2.45115225
15MP0003828_pulmonary_edema2.35696263
16MP0000749_muscle_degeneration2.31740404
17MP0004036_abnormal_muscle_relaxation2.08356382
18MP0001299_abnormal_eye_distance/2.08228151
19MP0003646_muscle_fatigue2.08205252
20MP0005330_cardiomyopathy2.05316139
21MP0000750_abnormal_muscle_regeneration2.02755601
22MP0006138_congestive_heart_failure2.02020830
23MP0002108_abnormal_muscle_morphology1.91281330
24* MP0004087_abnormal_muscle_fiber1.90921664
25MP0004484_altered_response_of1.83413695
26MP0010030_abnormal_orbit_morphology1.81188203
27MP0005385_cardiovascular_system_phenoty1.78952893
28MP0001544_abnormal_cardiovascular_syste1.78952893
29MP0002972_abnormal_cardiac_muscle1.75436608
30MP0004130_abnormal_muscle_cell1.72078629
31MP0005248_abnormal_Harderian_gland1.71752461
32MP0001958_emphysema1.71061293
33MP0005620_abnormal_muscle_contractility1.69686198
34MP0008775_abnormal_heart_ventricle1.68306658
35MP0010630_abnormal_cardiac_muscle1.68008160
36MP0000613_abnormal_salivary_gland1.66475426
37MP0003724_increased_susceptibility_to1.65248812
38MP0002233_abnormal_nose_morphology1.64432777
39MP0004145_abnormal_muscle_electrophysio1.63455546
40MP0005670_abnormal_white_adipose1.62774895
41MP0009250_abnormal_appendicular_skeleto1.61491236
42MP0003950_abnormal_plasma_membrane1.60228851
43MP0006054_spinal_hemorrhage1.59316890
44MP0000343_altered_response_to1.56536981
45MP0002106_abnormal_muscle_physiology1.55256624
46MP0005167_abnormal_blood-brain_barrier1.55100122
47MP0000767_abnormal_smooth_muscle1.54769540
48MP0005369_muscle_phenotype1.54699307
49MP0009053_abnormal_anal_canal1.51683655
50* MP0000759_abnormal_skeletal_muscle1.51168466
51* MP0002114_abnormal_axial_skeleton1.51150460
52MP0002116_abnormal_craniofacial_bone1.50510887
53MP0003122_maternal_imprinting1.48272475
54MP0000428_abnormal_craniofacial_morphol1.42613291
55* MP0005508_abnormal_skeleton_morphology1.41805929
56MP0003566_abnormal_cell_adhesion1.36588941
57* MP0003385_abnormal_body_wall1.35596674
58MP0002332_abnormal_exercise_endurance1.32402270
59* MP0003755_abnormal_palate_morphology1.31968884
60MP0005623_abnormal_meninges_morphology1.31886996
61MP0000534_abnormal_ureter_morphology1.31325405
62MP0002295_abnormal_pulmonary_circulatio1.26538237
63MP0000013_abnormal_adipose_tissue1.25290378
64* MP0002109_abnormal_limb_morphology1.23002405
65MP0003942_abnormal_urinary_system1.22874670
66MP0003137_abnormal_impulse_conducting1.21571717
67MP0005666_abnormal_adipose_tissue1.21441891
68MP0002249_abnormal_larynx_morphology1.20927473
69MP0002127_abnormal_cardiovascular_syste1.18832367
70MP0004085_abnormal_heartbeat1.16805043
71* MP0001177_atelectasis1.15429421
72* MP0000733_abnormal_muscle_development1.15106952
73MP0001270_distended_abdomen1.13863183
74MP0009384_cardiac_valve_regurgitation1.13389834
75MP0003567_abnormal_fetal_cardiomyocyte1.09666498
76MP0004185_abnormal_adipocyte_glucose1.09547676
77* MP0000266_abnormal_heart_morphology1.08477967
78* MP0002128_abnormal_blood_circulation1.08297550
79MP0000003_abnormal_adipose_tissue1.04553440
80MP0005187_abnormal_penis_morphology1.04429433
81MP0005375_adipose_tissue_phenotype1.04273350
82MP0002896_abnormal_bone_mineralization1.04009949
83* MP0002113_abnormal_skeleton_development1.03753729
84MP0003938_abnormal_ear_development1.03471054
85MP0002269_muscular_atrophy1.02910431
86MP0000537_abnormal_urethra_morphology1.02342048
87MP0005257_abnormal_intraocular_pressure1.02020573
88* MP0002925_abnormal_cardiovascular_devel1.01841406
89MP0002282_abnormal_trachea_morphology1.00081271
90MP0002277_abnormal_respiratory_mucosa0.99597872
91MP0000747_muscle_weakness0.99565200
92MP0000432_abnormal_head_morphology0.98248588
93MP0000049_abnormal_middle_ear0.95947589
94MP0004233_abnormal_muscle_weight0.95745066
95MP0003123_paternal_imprinting0.95362303
96* MP0001614_abnormal_blood_vessel0.94162099
97MP0002971_abnormal_brown_adipose0.93097367
98MP0002932_abnormal_joint_morphology0.90915157
99MP0004858_abnormal_nervous_system0.90042328
100MP0003937_abnormal_limbs/digits/tail_de0.88040112
101MP0000163_abnormal_cartilage_morphology0.87537518
102MP0005171_absent_coat_pigmentation0.87017862
103MP0005595_abnormal_vascular_smooth0.84183989
104MP0002115_abnormal_skeleton_extremities0.84167411
105MP0009780_abnormal_chondrocyte_physiolo0.83750686
106MP0003935_abnormal_craniofacial_develop0.83224172
107MP0001485_abnormal_pinna_reflex0.83025405
108MP0002060_abnormal_skin_morphology0.81657445
109MP0003941_abnormal_skin_development0.81431750
110MP0005165_increased_susceptibility_to0.81403488
111MP0005409_darkened_coat_color0.79800495
112MP0003045_fibrosis0.79549809
113MP0005023_abnormal_wound_healing0.79299402
114* MP0005388_respiratory_system_phenotype0.78715874
115* MP0002133_abnormal_respiratory_system0.78715874
116MP0000516_abnormal_urinary_system0.78200318
117MP0005367_renal/urinary_system_phenotyp0.78200318
118* MP0003115_abnormal_respiratory_system0.77979674
119MP0000762_abnormal_tongue_morphology0.76859012
120MP0002184_abnormal_innervation0.76323578
121MP0001661_extended_life_span0.73789202
122* MP0005390_skeleton_phenotype0.72908608
123MP0001542_abnormal_bone_strength0.72294178
124MP0003091_abnormal_cell_migration0.71348882
125MP0006072_abnormal_retinal_apoptosis0.71283279
126MP0009278_abnormal_bone_marrow0.70332875
127MP0004134_abnormal_chest_morphology0.70287409
128* MP0001175_abnormal_lung_morphology0.68867058
129MP0001286_abnormal_eye_development0.68388566
130MP0000467_abnormal_esophagus_morphology0.68242153
131MP0000249_abnormal_blood_vessel0.68056451
132MP0003948_abnormal_gas_homeostasis0.68028947
133MP0000566_synostosis0.67146857
134* MP0001943_abnormal_respiration0.64288756
135MP0002877_abnormal_melanocyte_morpholog0.62184418
136MP0002752_abnormal_somatic_nervous0.61645135
137MP0000026_abnormal_inner_ear0.61416020
138MP0001243_abnormal_dermal_layer0.61301027
139* MP0002111_abnormal_tail_morphology0.59776726
140MP0005193_abnormal_anterior_eye0.59719217

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.06900015
2Lip pit (HP:0100267)4.89889369
3Increased connective tissue (HP:0009025)4.89276856
4Abnormality of the calcaneus (HP:0008364)4.83568121
5Muscle fiber splitting (HP:0003555)4.57359190
6Type 1 muscle fiber predominance (HP:0003803)4.39947625
7Broad metatarsal (HP:0001783)4.24679990
8Sudden death (HP:0001699)4.13985154
9Arterial tortuosity (HP:0005116)3.98025606
10Vascular tortuosity (HP:0004948)3.84421978
11Premature rupture of membranes (HP:0001788)3.83342413
12Infantile muscular hypotonia (HP:0008947)3.81722047
13Spinal rigidity (HP:0003306)3.67998743
14Increased variability in muscle fiber diameter (HP:0003557)3.66125868
15Atrioventricular block (HP:0001678)3.64628385
16Ventricular tachycardia (HP:0004756)3.62915448
17Lipoatrophy (HP:0100578)3.50077306
18Abnormality of the calf musculature (HP:0001430)3.46462617
19Atrial fibrillation (HP:0005110)3.45853357
20Abnormality of the 4th metacarpal (HP:0010012)3.44653434
21Genu recurvatum (HP:0002816)3.40887354
22Hyporeflexia of lower limbs (HP:0002600)3.38606326
23Exercise-induced muscle cramps (HP:0003710)3.38497117
24Shallow orbits (HP:0000586)3.35957346
25Abnormality of skeletal muscle fiber size (HP:0012084)3.35067178
26Exercise-induced myalgia (HP:0003738)3.34300015
27Spondylolisthesis (HP:0003302)3.28190020
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26004640
29Short 4th metacarpal (HP:0010044)3.26004640
30Midline defect of the nose (HP:0004122)3.24653430
31Ankle contracture (HP:0006466)3.23897222
32Calf muscle hypertrophy (HP:0008981)3.23310150
33Primary atrial arrhythmia (HP:0001692)3.22197273
34Supraventricular arrhythmia (HP:0005115)3.13890415
35Cerebral aneurysm (HP:0004944)3.08839972
36Supraventricular tachycardia (HP:0004755)3.05267068
37Aortic dissection (HP:0002647)2.99861576
38Muscle hypertrophy of the lower extremities (HP:0008968)2.96743979
39Soft skin (HP:0000977)2.88243344
40Aortic aneurysm (HP:0004942)2.87710945
41Right ventricular cardiomyopathy (HP:0011663)2.85731768
42Hypoplastic ischia (HP:0003175)2.80724594
43Difficulty running (HP:0009046)2.80339731
44Bladder diverticulum (HP:0000015)2.79274759
45EMG: myopathic abnormalities (HP:0003458)2.76998945
46Follicular hyperkeratosis (HP:0007502)2.73619700
47Absent phalangeal crease (HP:0006109)2.71745098
48Subaortic stenosis (HP:0001682)2.66863028
49Abnormality of the left ventricular outflow tract (HP:0011103)2.66863028
50Bowel diverticulosis (HP:0005222)2.62343999
51Myoglobinuria (HP:0002913)2.60823903
52Mildly elevated creatine phosphokinase (HP:0008180)2.59300804
53Syringomyelia (HP:0003396)2.56754606
54Spinal cord lesions (HP:0100561)2.56754606
55Pulmonary artery stenosis (HP:0004415)2.53654017
56Bell-shaped thorax (HP:0001591)2.51652467
57Wrist flexion contracture (HP:0001239)2.51195898
58Myotonia (HP:0002486)2.50694080
59Abnormality of the ischium (HP:0003174)2.50344159
60Dilated cardiomyopathy (HP:0001644)2.50007990
61Lymphangioma (HP:0100764)2.48449056
62Heart block (HP:0012722)2.46967524
63Muscle fiber inclusion bodies (HP:0100299)2.45466175
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.44285559
65Abnormal atrioventricular conduction (HP:0005150)2.43704689
66Ulnar deviation of the wrist (HP:0003049)2.42854284
67Ectopia lentis (HP:0001083)2.40680601
68Mitral valve prolapse (HP:0001634)2.38759460
69Mesomelia (HP:0003027)2.30991952
70Difficulty climbing stairs (HP:0003551)2.30255640
71Slender build (HP:0001533)2.27373229
72Atrophic scars (HP:0001075)2.27026407
73Prolonged QT interval (HP:0001657)2.24423880
74Abnormal finger flexion creases (HP:0006143)2.24139212
75Dilatation of the ascending aorta (HP:0005111)2.24104998
76Abnormal delivery (HP:0001787)2.23990154
77Neoplasm of the heart (HP:0100544)2.23100632
78Vertebral compression fractures (HP:0002953)2.22799779
79Hip contracture (HP:0003273)2.19230811
80Scapular winging (HP:0003691)2.17951989
81Periauricular skin pits (HP:0100277)2.17178308
82Preauricular pit (HP:0004467)2.17178308
83Shawl scrotum (HP:0000049)2.16226614
84Round ear (HP:0100830)2.16090941
85Flexion contracture of toe (HP:0005830)2.15815201
86Joint contractures involving the joints of the feet (HP:0100492)2.15815201
87Wide anterior fontanel (HP:0000260)2.14587312
88Fused cervical vertebrae (HP:0002949)2.13044187
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11797596
90Fragile skin (HP:0001030)2.11742054
91Nemaline bodies (HP:0003798)2.10695841
92Rhabdomyolysis (HP:0003201)2.06148953
93Short hallux (HP:0010109)2.04670901
94Aneurysm (HP:0002617)2.04323902
95Flat cornea (HP:0007720)2.04180820
96Metatarsus adductus (HP:0001840)2.03993145
97Breech presentation (HP:0001623)2.01824766
98Hallux valgus (HP:0001822)2.01543153
99Deviation of the hallux (HP:0010051)2.01112306
100Deformed tarsal bones (HP:0008119)2.00721354
101Coronal craniosynostosis (HP:0004440)2.00291367
102Palpitations (HP:0001962)1.99924904
103Biconcave vertebral bodies (HP:0004586)1.99881007
104Cervical subluxation (HP:0003308)1.99696362
105Wormian bones (HP:0002645)1.98909058
106Limited hip movement (HP:0008800)1.98527268
107Rectal prolapse (HP:0002035)1.97102659
108Long toe (HP:0010511)1.94852166
109Inguinal hernia (HP:0000023)1.94566739
110Calcaneovalgus deformity (HP:0001848)1.93186876
111Camptodactyly of toe (HP:0001836)1.93146505
112Blue sclerae (HP:0000592)1.92422287
113Abnormality of the peritoneum (HP:0002585)1.89781402
114Venous abnormality (HP:0002624)1.88545561
115Muscle stiffness (HP:0003552)1.88436044
116Osteoarthritis (HP:0002758)1.88367962
117Asymmetry of the thorax (HP:0001555)1.87501671
118Distal arthrogryposis (HP:0005684)1.87153963
119Aplasia/Hypoplasia of the hallux (HP:0008362)1.84045791
120Turricephaly (HP:0000262)1.83964837
121Joint laxity (HP:0001388)1.83794853
122Rocker bottom foot (HP:0001838)1.82821272
123Cutaneous syndactyly (HP:0012725)1.81850906
124Elbow flexion contracture (HP:0002987)1.81073811
125Overgrowth (HP:0001548)1.80444628
126Neonatal short-limb short stature (HP:0008921)1.80006496
127Abnormal umbilical cord blood vessels (HP:0011403)1.79176774
128Single umbilical artery (HP:0001195)1.79176774
129Abnormality of the fetal cardiovascular system (HP:0010948)1.79176774
130Abnormality of dentin (HP:0010299)1.78108897
131Asymmetric septal hypertrophy (HP:0001670)1.77385266
132Cupped ribs (HP:0000887)1.76976052
133Reduced subcutaneous adipose tissue (HP:0003758)1.76943654
134Limb-girdle muscle weakness (HP:0003325)1.76776626
135Mesangial abnormality (HP:0001966)1.76560061
136Peritonitis (HP:0002586)1.76123686
137Syncope (HP:0001279)1.75780761
138Venous insufficiency (HP:0005293)1.75525464
139Distal lower limb muscle weakness (HP:0009053)1.75129198
140Cutaneous finger syndactyly (HP:0010554)1.74979967
141Neck muscle weakness (HP:0000467)1.73633764
142Abnormality of the phalanges of the hallux (HP:0010057)1.72549720
143Hematochezia (HP:0002573)1.71004666
144Ventricular arrhythmia (HP:0004308)1.69638083
145Obstructive sleep apnea (HP:0002870)1.69437300
146Hyperextensible skin (HP:0000974)1.69213622
147Osteolytic defects of the hand bones (HP:0009699)1.67433773
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.67433773
149Sprengel anomaly (HP:0000912)1.66630092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.82415578
2TTN4.49892830
3MKNK24.21695838
4EPHA33.52250788
5OBSCN2.95479218
6MYLK2.89316127
7RIPK12.85970946
8TRIB32.60999259
9TGFBR22.59277270
10DMPK2.50787276
11EEF2K2.45294370
12LMTK22.32431348
13KDR2.30038137
14ERBB42.27584132
15MOS2.26545130
16PHKG22.09278289
17PHKG12.09278289
18DDR22.08716312
19PDGFRA2.07502729
20ERN12.04391505
21TGFBR11.93865800
22EPHB21.92470547
23PTK2B1.82185610
24MAP3K31.81268730
25PKN21.81262223
26NTRK11.79844876
27LATS21.73267140
28LATS11.69165681
29PDK21.66559035
30PDK31.63902356
31PDK41.63902356
32SIK11.55176988
33PAK61.53986031
34CDK121.40616062
35FLT31.38966353
36FER1.37578387
37PIK3CA1.36785231
38MAP2K31.32823425
39STK381.17312637
40ILK1.09146058
41NEK91.06478305
42ERBB31.03404051
43PTK61.00993745
44BCKDK0.98873536
45STK38L0.97745397
46PRKD10.96797712
47ROCK10.95288991
48ZAK0.93435525
49AKT30.92495065
50DYRK1A0.86854839
51PRKD30.82878071
52MAPK120.81063744
53PRKAA20.80415026
54EPHB10.79594085
55MET0.78934041
56PRKD20.78435323
57STK240.76150410
58PRKG20.76051782
59CAMK1D0.73627440
60NLK0.73194262
61BRD40.68974528
62NEK10.68946264
63FGFR10.68633740
64FGFR40.65837514
65MAP3K100.65272135
66PAK20.65099821
67ICK0.64435340
68PRKCH0.64220640
69PAK30.63849136
70PDGFRB0.63071810
71FGFR30.61898029
72LRRK20.59747584
73PAK40.56939050
74STK30.56932739
75MAP3K70.56570436
76PTK20.54960342
77PRKG10.49869442
78MTOR0.49844179
79TRPM70.49731201
80EIF2AK20.48143520
81MAPK70.47698568
82FGFR20.47158928
83PRKCE0.47071337
84CAMK1G0.46603277
85GSK3A0.46580131
86PRPF4B0.45618884
87MARK30.45255701
88MARK20.44614239
89TYRO30.43144862
90PLK20.43068666
91ROCK20.42981369
92IGF1R0.42880445
93TAOK20.42071643
94MAPKAPK30.41904398
95CAMK40.41748277
96RPS6KA40.39884828
97WNK10.39745251
98CLK10.39729951
99SMG10.38374971
100JAK10.38323129
101PRKAA10.38249407
102MAPK100.37899251
103CDK30.37826524
104BCR0.36515972
105CDC42BPA0.36480851
106JAK30.35812185
107MAP3K60.35320382
108NME10.34702690
109MELK0.33225253
110NTRK20.33142484
111CDK80.32849668
112BMX0.29390546
113NEK20.29292090
114CDK90.27960962
115PRKACB0.27645211
116CAMK2D0.27605391
117SRC0.27170488
118RPS6KC10.27121633
119RPS6KL10.27121633
120INSR0.26598380
121CDK60.26406601
122CAMK10.26405423
123RET0.26020895
124MAPKAPK20.25220564
125MAPKAPK50.24829959
126PIK3CG0.24237529
127MAPK30.23368263
128TAF10.23363550
129MAPK10.23194175
130MKNK10.23087833
131MUSK0.22792223
132MAPK110.22792110
133GRK70.21860562
134ADRBK10.21524656
135RPS6KA60.19904118

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.99656134
2Dilated cardiomyopathy_Homo sapiens_hsa054143.67868775
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.58299579
4ECM-receptor interaction_Homo sapiens_hsa045123.30812851
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.85189451
6Focal adhesion_Homo sapiens_hsa045102.68365443
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33258437
8Malaria_Homo sapiens_hsa051442.25853086
9Propanoate metabolism_Homo sapiens_hsa006402.20936311
10Viral myocarditis_Homo sapiens_hsa054162.19412631
11Adherens junction_Homo sapiens_hsa045202.09058416
12Cardiac muscle contraction_Homo sapiens_hsa042602.03810838
13Fatty acid degradation_Homo sapiens_hsa000711.91542195
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.91472375
15Protein digestion and absorption_Homo sapiens_hsa049741.80540112
16Insulin resistance_Homo sapiens_hsa049311.71398100
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64181034
18PPAR signaling pathway_Homo sapiens_hsa033201.60851528
19Colorectal cancer_Homo sapiens_hsa052101.59504764
20Fatty acid metabolism_Homo sapiens_hsa012121.50206013
21Proteoglycans in cancer_Homo sapiens_hsa052051.49472335
22Small cell lung cancer_Homo sapiens_hsa052221.45054255
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43101439
24Amoebiasis_Homo sapiens_hsa051461.36451075
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33175225
26Basal cell carcinoma_Homo sapiens_hsa052171.31918374
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.29193037
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27215898
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26674607
30Pancreatic cancer_Homo sapiens_hsa052121.26203377
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.25717486
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24999813
33Tight junction_Homo sapiens_hsa045301.24008195
34TGF-beta signaling pathway_Homo sapiens_hsa043501.22221655
35Glioma_Homo sapiens_hsa052141.14704099
36Sulfur metabolism_Homo sapiens_hsa009201.13237383
37Hippo signaling pathway_Homo sapiens_hsa043901.06463629
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.06229856
39Carbon metabolism_Homo sapiens_hsa012001.05730568
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.04993019
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04562442
42Renin-angiotensin system_Homo sapiens_hsa046141.01850605
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99760130
44Renin secretion_Homo sapiens_hsa049240.99322291
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98524139
46Platelet activation_Homo sapiens_hsa046110.98144201
47AMPK signaling pathway_Homo sapiens_hsa041520.97987497
48Rap1 signaling pathway_Homo sapiens_hsa040150.93733188
49Axon guidance_Homo sapiens_hsa043600.92302324
50Insulin signaling pathway_Homo sapiens_hsa049100.90910775
51HIF-1 signaling pathway_Homo sapiens_hsa040660.90247915
52Pathways in cancer_Homo sapiens_hsa052000.90170502
53Toxoplasmosis_Homo sapiens_hsa051450.89607303
54Parkinsons disease_Homo sapiens_hsa050120.88350305
55MicroRNAs in cancer_Homo sapiens_hsa052060.88304052
56Endometrial cancer_Homo sapiens_hsa052130.88096061
57Glucagon signaling pathway_Homo sapiens_hsa049220.86952356
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83377566
59Notch signaling pathway_Homo sapiens_hsa043300.82159547
60Lysine degradation_Homo sapiens_hsa003100.82015612
61HTLV-I infection_Homo sapiens_hsa051660.81097390
62Hedgehog signaling pathway_Homo sapiens_hsa043400.79418576
63Circadian entrainment_Homo sapiens_hsa047130.78543187
64Oxytocin signaling pathway_Homo sapiens_hsa049210.75607422
65African trypanosomiasis_Homo sapiens_hsa051430.75266804
66Non-small cell lung cancer_Homo sapiens_hsa052230.75051948
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73807920
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72687225
69ErbB signaling pathway_Homo sapiens_hsa040120.72208537
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71851317
71Choline metabolism in cancer_Homo sapiens_hsa052310.71483611
72GnRH signaling pathway_Homo sapiens_hsa049120.70042644
73Pyruvate metabolism_Homo sapiens_hsa006200.67667767
74TNF signaling pathway_Homo sapiens_hsa046680.65721492
75mTOR signaling pathway_Homo sapiens_hsa041500.64978560
76Starch and sucrose metabolism_Homo sapiens_hsa005000.63302052
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.62979586
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62149173
79Alzheimers disease_Homo sapiens_hsa050100.61777614
80Melanoma_Homo sapiens_hsa052180.61760654
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59385523
82Wnt signaling pathway_Homo sapiens_hsa043100.58965265
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.58694601
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57284028
85Gap junction_Homo sapiens_hsa045400.56873954
86cAMP signaling pathway_Homo sapiens_hsa040240.56866461
87Histidine metabolism_Homo sapiens_hsa003400.56517539
88Ovarian steroidogenesis_Homo sapiens_hsa049130.56509717
89Prostate cancer_Homo sapiens_hsa052150.56079838
90Melanogenesis_Homo sapiens_hsa049160.54393682
91Calcium signaling pathway_Homo sapiens_hsa040200.53996532
92Type II diabetes mellitus_Homo sapiens_hsa049300.53338947
93Circadian rhythm_Homo sapiens_hsa047100.52906694
94Fatty acid biosynthesis_Homo sapiens_hsa000610.52563737
95Cholinergic synapse_Homo sapiens_hsa047250.50972136
96Chronic myeloid leukemia_Homo sapiens_hsa052200.50387715
97Long-term potentiation_Homo sapiens_hsa047200.49121331
98Dorso-ventral axis formation_Homo sapiens_hsa043200.47661408
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.44648102
100Selenocompound metabolism_Homo sapiens_hsa004500.43075486
101Acute myeloid leukemia_Homo sapiens_hsa052210.42660133
102beta-Alanine metabolism_Homo sapiens_hsa004100.42431823
103Glycerolipid metabolism_Homo sapiens_hsa005610.40378511
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40237845
105Ras signaling pathway_Homo sapiens_hsa040140.40236588
106Renal cell carcinoma_Homo sapiens_hsa052110.38460138
107Prolactin signaling pathway_Homo sapiens_hsa049170.38294093
108Estrogen signaling pathway_Homo sapiens_hsa049150.37704807
109FoxO signaling pathway_Homo sapiens_hsa040680.37703823
110Galactose metabolism_Homo sapiens_hsa000520.37271117
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37245265
112Inositol phosphate metabolism_Homo sapiens_hsa005620.37157722
113Huntingtons disease_Homo sapiens_hsa050160.36564814
114Oxidative phosphorylation_Homo sapiens_hsa001900.36204514
115Prion diseases_Homo sapiens_hsa050200.35893355
116Morphine addiction_Homo sapiens_hsa050320.35431423
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35326387
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35149468
119Thyroid cancer_Homo sapiens_hsa052160.35003344
120Legionellosis_Homo sapiens_hsa051340.34580587
121Arginine and proline metabolism_Homo sapiens_hsa003300.33265451
122VEGF signaling pathway_Homo sapiens_hsa043700.32824267
123MAPK signaling pathway_Homo sapiens_hsa040100.31772787
124Caffeine metabolism_Homo sapiens_hsa002320.30361403
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30281533
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29753917
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28778004
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27015031
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26192661

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