MEP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)7.70158680
2epoxygenase P450 pathway (GO:0019373)7.56092707
3fat-soluble vitamin biosynthetic process (GO:0042362)7.27198139
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.16030753
5modified amino acid transport (GO:0072337)6.62322332
6vitamin A metabolic process (GO:0006776)6.40464207
7drug catabolic process (GO:0042737)6.32623406
8positive regulation of guanylate cyclase activity (GO:0031284)6.21768120
9adhesion of symbiont to host cell (GO:0044650)6.15644342
10virion attachment to host cell (GO:0019062)6.15644342
11actin filament depolymerization (GO:0030042)5.80178221
12drug transmembrane transport (GO:0006855)5.53526396
13drug transport (GO:0015893)5.51565095
14cellular glucuronidation (GO:0052695)5.31075733
15regulation of bile acid biosynthetic process (GO:0070857)5.29558254
16flavonoid metabolic process (GO:0009812)5.23671158
17glucuronate metabolic process (GO:0019585)5.19823937
18uronic acid metabolic process (GO:0006063)5.19823937
19peptide catabolic process (GO:0043171)5.01240704
20digestive system process (GO:0022600)4.98906476
21adhesion of symbiont to host (GO:0044406)4.92452290
22regulation of cGMP biosynthetic process (GO:0030826)4.66027923
23sulfur compound transport (GO:0072348)4.64834126
24urea cycle (GO:0000050)4.59858330
25urate metabolic process (GO:0046415)4.59518395
26UDP-N-acetylglucosamine metabolic process (GO:0006047)4.58184246
27hormone catabolic process (GO:0042447)4.56808844
28receptor guanylyl cyclase signaling pathway (GO:0007168)4.53373628
29regulation of cellular extravasation (GO:0002691)4.52801848
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.47687428
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.47617047
32purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.47617047
33glycolipid catabolic process (GO:0019377)4.46873772
34positive regulation of lipoprotein lipase activity (GO:0051006)4.42636774
35positive regulation of triglyceride lipase activity (GO:0061365)4.42636774
36urea metabolic process (GO:0019627)4.41935776
37glycosphingolipid catabolic process (GO:0046479)4.40354687
38glucose 6-phosphate metabolic process (GO:0051156)4.39403766
39regulation of cholesterol esterification (GO:0010872)4.38831912
40lipoprotein metabolic process (GO:0042157)4.38513600
41NADH metabolic process (GO:0006734)4.38233183
42lysine metabolic process (GO:0006553)4.36385713
43lysine catabolic process (GO:0006554)4.36385713
44renal system process involved in regulation of blood volume (GO:0001977)4.28321209
45oligosaccharide catabolic process (GO:0009313)4.27947686
46phospholipid efflux (GO:0033700)4.27328574
47bile acid and bile salt transport (GO:0015721)4.23403424
48transepithelial transport (GO:0070633)4.20929224
49cellular response to hepatocyte growth factor stimulus (GO:0035729)4.20924009
50response to hepatocyte growth factor (GO:0035728)4.20924009
51cellular response to nitric oxide (GO:0071732)4.20789061
52plasma lipoprotein particle assembly (GO:0034377)4.20108763
53sulfate transmembrane transport (GO:1902358)4.19684114
54renal absorption (GO:0070293)4.19593468
55fat-soluble vitamin metabolic process (GO:0006775)4.19167789
56cysteine metabolic process (GO:0006534)4.17300101
57response to phenylpropanoid (GO:0080184)4.12591367
58polyol transport (GO:0015791)4.10925169
59regulation of triglyceride catabolic process (GO:0010896)4.10024109
60regulation of vitamin metabolic process (GO:0030656)4.07847608
61protein-lipid complex assembly (GO:0065005)4.05808762
62nitrogen cycle metabolic process (GO:0071941)4.05715247
63alkaloid metabolic process (GO:0009820)3.98665434
64peptide hormone processing (GO:0016486)3.97164606
65diacylglycerol metabolic process (GO:0046339)3.97014606
66fructose metabolic process (GO:0006000)3.96042653
67vitamin transmembrane transport (GO:0035461)3.89581889
68lipoprotein transport (GO:0042953)3.89017047
69exogenous drug catabolic process (GO:0042738)3.88655565
70regulation of cGMP metabolic process (GO:0030823)3.88191422
71drinking behavior (GO:0042756)3.85247399
72bundle of His cell to Purkinje myocyte communication (GO:0086069)3.82802721
73homocysteine metabolic process (GO:0050667)3.82687912
74regulation of cholesterol homeostasis (GO:2000188)3.80866800
75negative regulation of sterol transport (GO:0032372)3.77661078
76negative regulation of cholesterol transport (GO:0032375)3.77661078
77mRNA modification (GO:0016556)3.76322632
78sterol homeostasis (GO:0055092)3.75926907
79cholesterol homeostasis (GO:0042632)3.73553809
80glutathione biosynthetic process (GO:0006750)3.73002132
81nonribosomal peptide biosynthetic process (GO:0019184)3.71053750
82cGMP biosynthetic process (GO:0006182)3.69572095
83vitamin D metabolic process (GO:0042359)3.69273518
84intestinal epithelial cell development (GO:0060576)3.68527680
85vitamin biosynthetic process (GO:0009110)3.65492016
86very-low-density lipoprotein particle assembly (GO:0034379)3.63471428
87glutamine family amino acid biosynthetic process (GO:0009084)3.62648008
88vitamin transport (GO:0051180)3.60898514
89bile acid metabolic process (GO:0008206)3.60873140
90* digestion (GO:0007586)3.60019307
91cholesterol efflux (GO:0033344)3.59258525
92bicarbonate transport (GO:0015701)3.58699880
93positive regulation of cGMP biosynthetic process (GO:0030828)3.58448650
94organic cation transport (GO:0015695)3.57386461
95ceramide catabolic process (GO:0046514)3.56793806
96cellular carbohydrate catabolic process (GO:0044275)3.56669389
97fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.55585635
98cellular response to reactive nitrogen species (GO:1902170)3.52901307
99response to nitric oxide (GO:0071731)3.47254937
100glycosylceramide metabolic process (GO:0006677)3.46706680
101sulfate transport (GO:0008272)3.46311290
102midgut development (GO:0007494)3.44610882
103antibacterial humoral response (GO:0019731)3.42218324
104cobalamin metabolic process (GO:0009235)3.40616186
105heme transport (GO:0015886)3.38492024
106positive regulation of glycoprotein biosynthetic process (GO:0010560)3.37764791
107excretion (GO:0007588)3.37190688
108maintenance of gastrointestinal epithelium (GO:0030277)3.37137196
109regulation of systemic arterial blood pressure by hormone (GO:0001990)3.34871068
110regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.34871068
111endocrine process (GO:0050886)3.34871068
112glycerol metabolic process (GO:0006071)3.34646717
113response to hydroperoxide (GO:0033194)3.34271309
114alditol metabolic process (GO:0019400)3.32741969
115omega-hydroxylase P450 pathway (GO:0097267)3.31487141
116cytidine deamination (GO:0009972)3.30932942
117cytidine metabolic process (GO:0046087)3.30932942
118cytidine catabolic process (GO:0006216)3.30932942
119positive regulation of lipid catabolic process (GO:0050996)3.30596634
120antimicrobial humoral response (GO:0019730)3.30066459
121glomerulus development (GO:0032835)3.30047741
122sphingolipid catabolic process (GO:0030149)3.29733426
123drug metabolic process (GO:0017144)3.28084799
124phosphate ion transport (GO:0006817)3.27962859
125citrulline biosynthetic process (GO:0019240)3.26992730
126negative regulation of digestive system process (GO:0060457)3.26016181
127sulfation (GO:0051923)3.25489016
128sterol transport (GO:0015918)3.23406968
129cholesterol transport (GO:0030301)3.23406968
130hydrogen peroxide catabolic process (GO:0042744)3.22361878
131purine nucleotide salvage (GO:0032261)3.21716924
132thyroid hormone metabolic process (GO:0042403)3.21003111
133phosphate ion transmembrane transport (GO:0035435)3.18080702
134membrane lipid catabolic process (GO:0046466)3.17997490
135negative regulation of steroid metabolic process (GO:0045939)3.17594692
136O-glycan processing (GO:0016266)3.16866514
137positive regulation of fatty acid biosynthetic process (GO:0045723)3.15722138
138phenol-containing compound catabolic process (GO:0019336)3.15274412
139sphingomyelin metabolic process (GO:0006684)3.13612410
140regulation of digestive system process (GO:0044058)3.12098523
141peptide biosynthetic process (GO:0043043)3.09992844
142amino acid transmembrane transport (GO:0003333)3.09164603
143calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.06527345
144transcytosis (GO:0045056)3.06054302
145phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.05875751
146glutathione derivative biosynthetic process (GO:1901687)2.99707758
147glutathione derivative metabolic process (GO:1901685)2.99707758
148regulation of systemic arterial blood pressure (GO:0003073)2.95808459
149intestinal absorption (GO:0050892)11.3584895
150angiotensin maturation (GO:0002003)10.6873522
151intestinal cholesterol absorption (GO:0030299)10.4124243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.48658264
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.46089789
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.86543327
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.69488759
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.68082759
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38320350
7GATA4_25053715_ChIP-Seq_YYC3_Human3.23677114
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.13486041
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.01911629
10GATA1_22025678_ChIP-Seq_K562_Human3.00872167
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.93115259
12GATA6_25053715_ChIP-Seq_YYC3_Human2.90975638
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.64821722
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62842450
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55810248
16NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.40484625
17AR_21909140_ChIP-Seq_LNCAP_Human2.37526536
18SOX2_20726797_ChIP-Seq_SW620_Human2.35385375
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09630159
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.06738609
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.06180619
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03810022
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.92169175
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83345288
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.81903606
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81051264
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.74807789
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74470522
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64871160
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64467427
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.62453919
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.61320152
33RACK7_27058665_Chip-Seq_MCF-7_Human1.60808347
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58511841
35CLOCK_20551151_ChIP-Seq_293T_Human1.56879328
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.56331349
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55103107
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51601604
39ATF3_27146783_Chip-Seq_COLON_Human1.50325435
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.49175950
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48616167
42* KLF5_25053715_ChIP-Seq_YYC3_Human1.46399311
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45157421
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42475260
45VDR_22108803_ChIP-Seq_LS180_Human1.41151311
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39982488
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39804446
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39607419
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37316595
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.36261018
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.35097249
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34349041
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34265296
54FOXA1_25552417_ChIP-Seq_VCAP_Human1.33600792
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33467634
56GATA2_19941826_ChIP-Seq_K562_Human1.33022311
57ZNF263_19887448_ChIP-Seq_K562_Human1.31421002
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29922590
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28301922
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28171037
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26776636
62NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25791041
63RXR_22108803_ChIP-Seq_LS180_Human1.24139051
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23309824
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22749564
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21651417
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21372557
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21271537
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20743764
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.19072722
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18827340
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17443283
73CREB1_26743006_Chip-Seq_LNCaP_Human1.13993140
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13201765
75NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11876985
76GATA1_19941826_ChIP-Seq_K562_Human1.11578868
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10790881
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09451437
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08237262
80VDR_24787735_ChIP-Seq_THP-1_Human1.06706172
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05129031
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01854939
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99892373
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99687889
85OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99609365
86NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96342413
87NANOG_20526341_ChIP-Seq_ESCs_Human0.96022269
88LXR_22292898_ChIP-Seq_THP-1_Human0.95336919
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95142324
90* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94726847
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93880972
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93777442
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93589625
94SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93302779
95CEBPB_22108803_ChIP-Seq_LS180_Human0.92522319
96TP63_23658742_ChIP-Seq_EP156T_Human0.91603171
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90915106
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90870540
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89905910
100BCL6_27268052_Chip-Seq_Bcells_Human0.89499682
101SA1_27219007_Chip-Seq_Bcells_Human0.89418319
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.89316469
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89146302
104EGR1_19032775_ChIP-ChIP_M12_Human0.88939530
105BCOR_27268052_Chip-Seq_Bcells_Human0.88628304
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88235099
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87799048
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87595793
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87517933
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87153027
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85588265
112* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85191273
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84952697
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84949057
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82406563
116IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82008939
117FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81988631
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81682280
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80919299
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.80910229
121CDX2_22108803_ChIP-Seq_LS180_Human0.79972453
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79656601
123PHF8_20622854_ChIP-Seq_HELA_Human0.79006247
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78655010
125P68_20966046_ChIP-Seq_HELA_Human0.78517006
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.78482967
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77843916
128* KAP1_27257070_Chip-Seq_ESCs_Mouse0.77843274
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.77644314
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.77391311
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77352093
132SOX2_22085726_ChIP-Seq_NPCs_Mouse0.77186817
133GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76988667
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75580180
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75261171
136CTCF_27219007_Chip-Seq_Bcells_Human0.72851258
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72821327
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71628776
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70742976
140BCAT_22108803_ChIP-Seq_LS180_Human0.70549885
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69553727
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.69249478
143CBP_21632823_ChIP-Seq_H3396_Human0.69189091
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68692590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption5.44008434
2MP0002139_abnormal_hepatobiliary_system3.91925316
3MP0009840_abnormal_foam_cell3.45567811
4MP0004264_abnormal_extraembryonic_tissu3.40145224
5MP0005085_abnormal_gallbladder_physiolo3.31383955
6MP0004043_abnormal_pH_regulation3.24218964
7MP0010234_abnormal_vibrissa_follicle3.23008334
8MP0003183_abnormal_peptide_metabolism3.21169716
9MP0004019_abnormal_vitamin_homeostasis3.09535593
10MP0003252_abnormal_bile_duct3.09027070
11MP0008875_abnormal_xenobiotic_pharmacok3.07020729
12MP0003878_abnormal_ear_physiology2.74921015
13MP0005377_hearing/vestibular/ear_phenot2.74921015
14MP0005332_abnormal_amino_acid2.43693420
15MP0000462_abnormal_digestive_system2.38156919
16MP0005365_abnormal_bile_salt2.36849899
17MP0010329_abnormal_lipoprotein_level2.29572398
18MP0003866_abnormal_defecation2.26472901
19MP0005409_darkened_coat_color2.08101051
20MP0004147_increased_porphyrin_level2.07749460
21MP0009643_abnormal_urine_homeostasis2.05477690
22MP0005360_urolithiasis10.6432308
23MP0000538_abnormal_urinary_bladder1.92688050
24MP0005084_abnormal_gallbladder_morpholo1.90744066
25MP0005670_abnormal_white_adipose1.62539806
26MP0001765_abnormal_ion_homeostasis1.56105703
27MP0002822_catalepsy1.54034698
28MP0003191_abnormal_cellular_cholesterol1.53344031
29MP0000537_abnormal_urethra_morphology1.48984937
30MP0003806_abnormal_nucleotide_metabolis1.45719331
31MP0001663_abnormal_digestive_system1.45548139
32MP0005381_digestive/alimentary_phenotyp1.43795129
33MP0003300_gastrointestinal_ulcer1.39779218
34MP0010155_abnormal_intestine_physiology1.39541636
35MP0010352_gastrointestinal_tract_polyps1.38867129
36MP0001664_abnormal_digestion1.37482268
37MP0002876_abnormal_thyroid_physiology1.36454693
38MP0003705_abnormal_hypodermis_morpholog1.36064076
39MP0005636_abnormal_mineral_homeostasis1.34402322
40MP0002136_abnormal_kidney_physiology1.34399483
41MP0001188_hyperpigmentation1.34348049
42MP0000477_abnormal_intestine_morphology1.32163249
43MP0002089_abnormal_postnatal_growth/wei1.26515624
44MP0001756_abnormal_urination1.25011873
45MP0002796_impaired_skin_barrier1.24597736
46MP0001873_stomach_inflammation1.23960656
47MP0000490_abnormal_crypts_of1.21516788
48MP0001501_abnormal_sleep_pattern1.20358064
49MP0003718_maternal_effect1.15862135
50MP0005451_abnormal_body_composition1.11299439
51MP0002396_abnormal_hematopoietic_system1.09112527
52MP0005535_abnormal_body_temperature1.06814176
53MP0005448_abnormal_energy_balance1.06737204
54MP0002118_abnormal_lipid_homeostasis1.04007357
55MP0003283_abnormal_digestive_organ0.97091136
56MP0000609_abnormal_liver_physiology0.96474373
57MP0002971_abnormal_brown_adipose0.93746787
58MP0005319_abnormal_enzyme/_coenzyme0.90848062
59MP0002138_abnormal_hepatobiliary_system0.88015542
60MP0006054_spinal_hemorrhage0.87015140
61MP0002254_reproductive_system_inflammat0.86840095
62MP0001849_ear_inflammation0.85176999
63MP0001764_abnormal_homeostasis0.84317085
64MP0005167_abnormal_blood-brain_barrier0.81975554
65MP0005501_abnormal_skin_physiology0.80274337
66MP0004858_abnormal_nervous_system0.77950647
67MP0004782_abnormal_surfactant_physiolog0.77382816
68MP0003315_abnormal_perineum_morphology0.75775385
69MP0001845_abnormal_inflammatory_respons0.73752085
70MP0009697_abnormal_copulation0.72602319
71MP0005584_abnormal_enzyme/coenzyme_acti0.72207909
72MP0005266_abnormal_metabolism0.67471742
73MP0002098_abnormal_vibrissa_morphology0.66170209
74MP0003879_abnormal_hair_cell0.65506026
75MP0003868_abnormal_feces_composition0.65175635
76MP0003195_calcinosis0.63904026
77MP0000467_abnormal_esophagus_morphology0.62098389
78MP0006138_congestive_heart_failure0.61676555
79MP0009379_abnormal_foot_pigmentation0.60786636
80MP0010678_abnormal_skin_adnexa0.60472081
81MP0001485_abnormal_pinna_reflex0.59175557
82MP0009785_altered_susceptibility_to0.59083381
83MP0008872_abnormal_physiological_respon0.58973639
84MP0003638_abnormal_response/metabolism_0.58588387
85MP0004885_abnormal_endolymph0.58581461
86MP0000230_abnormal_systemic_arterial0.57370872
87MP0008961_abnormal_basal_metabolism0.57227858
88* MP0009642_abnormal_blood_homeostasis0.56747311
89MP0004947_skin_inflammation0.56596781
90MP0005367_renal/urinary_system_phenotyp0.56095038
91MP0000516_abnormal_urinary_system0.56095038
92MP0009764_decreased_sensitivity_to0.54906726
93MP0009053_abnormal_anal_canal0.54889588
94MP0005334_abnormal_fat_pad0.54095759
95MP0000249_abnormal_blood_vessel0.53982018
96MP0000465_gastrointestinal_hemorrhage0.53802426
97MP0003693_abnormal_embryo_hatching0.52908979
98MP0005310_abnormal_salivary_gland0.52323800
99MP0005166_decreased_susceptibility_to0.52174274
100MP0005174_abnormal_tail_pigmentation0.52085240
101MP0002166_altered_tumor_susceptibility0.51572943
102MP0003953_abnormal_hormone_level0.49063716
103MP0000678_abnormal_parathyroid_gland0.48343136
104MP0002078_abnormal_glucose_homeostasis0.48277778
105MP0009780_abnormal_chondrocyte_physiolo0.47869405
106MP0005376_homeostasis/metabolism_phenot0.47121221
107MP0004270_analgesia0.47063773
108MP0000015_abnormal_ear_pigmentation0.46258297
109MP0005666_abnormal_adipose_tissue0.44588596
110MP0008260_abnormal_autophagy0.44177353
111MP0006082_CNS_inflammation0.44141947
112MP0001216_abnormal_epidermal_layer0.43912582
113MP0009384_cardiac_valve_regurgitation0.43592404
114MP0003724_increased_susceptibility_to0.42437342
115MP0009115_abnormal_fat_cell0.41224986
116MP0009333_abnormal_splenocyte_physiolog0.40839111
117MP0002896_abnormal_bone_mineralization0.40493505
118MP0003453_abnormal_keratinocyte_physiol0.40210983
119MP0005395_other_phenotype0.40077267
120MP0001191_abnormal_skin_condition0.39428965
121MP0001881_abnormal_mammary_gland0.39197216
122MP0009765_abnormal_xenobiotic_induced0.37021078
123MP0005025_abnormal_response_to0.36891068
124MP0000598_abnormal_liver_morphology0.36367917
125MP0001835_abnormal_antigen_presentation0.35239978
126MP0004484_altered_response_of0.35115231
127MP0002135_abnormal_kidney_morphology0.34945653
128MP0000377_abnormal_hair_follicle0.34925568
129MP0000566_synostosis0.34506699
130MP0000604_amyloidosis0.32259303
131MP0008469_abnormal_protein_level0.31527402
132MP0008873_increased_physiological_sensi0.30843809

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.90866739
2Ileus (HP:0002595)6.83485093
3Hyperglycinuria (HP:0003108)5.71786409
4Abnormality of proline metabolism (HP:0010907)5.46447146
5Hydroxyprolinuria (HP:0003080)5.46447146
6Malnutrition (HP:0004395)5.36317937
7Hyperactive renin-angiotensin system (HP:0000841)4.88745731
8Hypobetalipoproteinemia (HP:0003563)4.86926858
9Acanthocytosis (HP:0001927)4.77815011
10Metabolic alkalosis (HP:0200114)4.63780775
11Autoimmune thrombocytopenia (HP:0001973)4.56239004
12Abnormality of chloride homeostasis (HP:0011422)4.38045633
13Abnormality of serine family amino acid metabolism (HP:0010894)4.25525618
14Abnormality of glycine metabolism (HP:0010895)4.25525618
15Abnormality of purine metabolism (HP:0004352)4.02638497
16Gout (HP:0001997)3.92635288
17Widely patent fontanelles and sutures (HP:0004492)3.92108791
18Conjugated hyperbilirubinemia (HP:0002908)3.84139917
19Increased circulating renin level (HP:0000848)3.83635557
20Glycosuria (HP:0003076)3.74230065
21Abnormality of urine glucose concentration (HP:0011016)3.74230065
22Abnormality of magnesium homeostasis (HP:0004921)3.72500918
23Proximal tubulopathy (HP:0000114)3.64145039
24Right ventricular cardiomyopathy (HP:0011663)3.60986438
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60173814
26Abnormal urine output (HP:0012590)3.57200064
27Fat malabsorption (HP:0002630)3.56928561
28Increased purine levels (HP:0004368)3.50498959
29Hyperuricemia (HP:0002149)3.50498959
30Hypomagnesemia (HP:0002917)3.50090694
31Chronic diarrhea (HP:0002028)3.48488456
32Facial shape deformation (HP:0011334)3.37638273
33Potter facies (HP:0002009)3.37638273
34Abnormality of renal excretion (HP:0011036)3.35492299
35Hypokalemic alkalosis (HP:0001949)3.32825063
36Nephrolithiasis (HP:0000787)3.30467113
37Steatorrhea (HP:0002570)3.29106110
38Dehydration (HP:0001944)3.27948550
39Abnormality of the vitamin B12 metabolism (HP:0004341)3.24840315
40Cupped ribs (HP:0000887)3.21823935
41Abnormality of sulfur amino acid metabolism (HP:0004339)3.21643608
42Decreased circulating renin level (HP:0003351)3.13317159
43Abnormality of nucleobase metabolism (HP:0010932)3.04917242
44Enlarged epiphyses (HP:0010580)3.02300629
45Posterior subcapsular cataract (HP:0007787)3.00435109
46Abnormality of vitamin B metabolism (HP:0004340)2.99850710
47Systemic lupus erythematosus (HP:0002725)2.99103898
48Pigmentary retinal degeneration (HP:0001146)2.93896430
49Autoimmune hemolytic anemia (HP:0001890)2.92258304
50Abdominal distention (HP:0003270)2.88840106
51Confusion (HP:0001289)2.88798066
52Hyperphosphaturia (HP:0003109)2.86125043
53Congenital sensorineural hearing impairment (HP:0008527)2.84848311
54Hypolipoproteinemia (HP:0010981)2.82997266
55Hyperaldosteronism (HP:0000859)2.81696527
56Abnormality of renin-angiotensin system (HP:0000847)2.79239582
57Polyuria (HP:0000103)2.73611893
58Ketoacidosis (HP:0001993)2.73566624
59Poikilocytosis (HP:0004447)2.73413413
60Alkalosis (HP:0001948)2.68425794
61Metabolic acidosis (HP:0001942)2.63739498
62Tetany (HP:0001281)2.62190346
63Hypercalciuria (HP:0002150)2.59024721
64Abnormality of the costochondral junction (HP:0000919)2.58527971
65Hyperparathyroidism (HP:0000843)2.55299731
66Xanthomatosis (HP:0000991)2.52560779
67Focal segmental glomerulosclerosis (HP:0000097)2.51837578
68Abnormal urine phosphate concentration (HP:0012599)2.50280119
69Wide cranial sutures (HP:0010537)2.44193481
70Epidermoid cyst (HP:0200040)2.43889271
71Hyperammonemia (HP:0001987)2.41379325
72Megaloblastic anemia (HP:0001889)2.40745815
73Abnormality of vitamin metabolism (HP:0100508)2.40637472
74Nausea (HP:0002018)2.36250657
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34752733
76Abnormality of fatty-acid metabolism (HP:0004359)2.30423471
77Eczematoid dermatitis (HP:0000976)2.29856586
78Mesangial abnormality (HP:0001966)2.29300831
79Abnormal glucose tolerance (HP:0001952)2.27430309
80Renal salt wasting (HP:0000127)2.25768469
81Gastrointestinal dysmotility (HP:0002579)2.25531564
82Delayed epiphyseal ossification (HP:0002663)2.23160260
83Flat acetabular roof (HP:0003180)2.19317340
84Subcapsular cataract (HP:0000523)2.18644983
85Protuberant abdomen (HP:0001538)2.16404858
86Intrahepatic cholestasis (HP:0001406)2.15764061
87Increased IgE level (HP:0003212)2.13004887
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12631915
89Abnormal tarsal ossification (HP:0008369)2.10394218
90Hypophosphatemia (HP:0002148)2.09901548
91Hypokalemia (HP:0002900)2.08133679
92Generalized aminoaciduria (HP:0002909)2.03638002
93Renal tubular dysfunction (HP:0000124)1.96831551
94Gingivitis (HP:0000230)1.96598220
95Abnormal drinking behavior (HP:0030082)1.95814090
96Polydipsia (HP:0001959)1.95814090
97Thin bony cortex (HP:0002753)1.94072957
98Hemorrhage of the eye (HP:0011885)1.93979664
99Irritability (HP:0000737)1.93869575
100Renal tubular acidosis (HP:0001947)1.92420891
101Cerebral palsy (HP:0100021)1.92390453
102Hypotension (HP:0002615)1.91994707
103Hyperphosphatemia (HP:0002905)1.90799300
104Ketosis (HP:0001946)1.88778803
105Pancreatitis (HP:0001733)1.85680672
106Hypophosphatemic rickets (HP:0004912)1.84093152
107Hyperglycinemia (HP:0002154)1.83684201
108Abnormal biliary tract morphology (HP:0012440)1.83434785
109Glomerulosclerosis (HP:0000096)1.82870771
110Metaphyseal irregularity (HP:0003025)1.81504382
111Multiple lipomas (HP:0001012)1.81462091
112Hypercholesterolemia (HP:0003124)1.81179781
113Villous atrophy (HP:0011473)1.80187615
114Abnormality of small intestinal villus morphology (HP:0011472)1.80187615
115Reticulocytosis (HP:0001923)1.80002095
116Dicarboxylic aciduria (HP:0003215)1.79927692
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79927692
118Abnormal enzyme/coenzyme activity (HP:0012379)1.78532711
119Abnormality of alkaline phosphatase activity (HP:0004379)1.77927224
120Goiter (HP:0000853)1.77554984
121B lymphocytopenia (HP:0010976)1.76521883
122Abnormality of B cell number (HP:0010975)1.76521883
123White forelock (HP:0002211)1.76176936
124Palpitations (HP:0001962)1.75662471
125Myopathic facies (HP:0002058)1.75481516
126Pustule (HP:0200039)1.74601446
127Vascular calcification (HP:0004934)1.73031043
128Patchy hypopigmentation of hair (HP:0011365)1.72445164
129Peripheral demyelination (HP:0011096)1.68463767
130Symptomatic seizures (HP:0011145)1.67307212
131Growth hormone excess (HP:0000845)1.65276483
132Hypocalcemia (HP:0002901)1.65155369
133Chorioretinal atrophy (HP:0000533)1.61234029
134Paresthesia (HP:0003401)1.61056616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.56324015
2FRK5.83150484
3MST45.55499400
4MST1R4.09271483
5LMTK23.92587123
6WNK33.86165069
7NME13.41677273
8GRK63.29407176
9AKT33.23830053
10OXSR13.05680371
11PRKG22.75877528
12WNK42.72261876
13EPHA22.48361302
14RIPK12.18450301
15MAP2K22.13592740
16PTK61.88806263
17MAP3K101.86779132
18TNIK1.76711783
19MAP3K21.62417777
20ERN11.60691936
21MAP3K121.50310306
22EPHA31.46470732
23NUAK11.45987703
24MET1.44805927
25TTK1.39961950
26STK101.38889452
27NEK11.38609519
28EPHA41.33130110
29EPHB21.32037711
30PRKCI1.31199242
31TESK21.29449801
32PDK21.28470348
33TESK11.20141378
34PDK41.18879065
35PDK31.18879065
36TAOK11.17933954
37STK391.04735977
38DDR21.04309361
39LATS11.03950867
40PAK41.00969098
41MAP3K80.99309958
42PRPF4B0.99166743
43PTK20.95438295
44NLK0.93292920
45FGFR30.93005516
46STK38L0.91872018
47MAP4K10.91852243
48MATK0.90045659
49MAP3K110.85583347
50MAP3K70.84989984
51PRKAA20.83153972
52MYLK0.82730931
53KSR20.82252645
54MAPK110.81855887
55FER0.81707816
56BMPR20.81607657
57BMX0.81327320
58CASK0.78902005
59EPHB10.75074210
60PRKAA10.74512628
61LRRK20.71777126
62MAP2K60.67500740
63MAP3K30.66959078
64ERBB20.65001948
65IRAK10.64789985
66PIK3CG0.61114714
67MAP2K10.59163903
68CDC42BPA0.57949096
69PDPK10.55175642
70ICK0.54840603
71YES10.53336279
72STK30.52346304
73RIPK40.50636381
74PIK3CA0.49879227
75ITK0.45381212
76TEC0.43912832
77DYRK1B0.43301875
78PBK0.42497407
79NEK60.42496573
80PAK30.41427520
81FYN0.41143441
82CAMK2D0.40265599
83AURKB0.40234876
84RET0.40228694
85SCYL20.38886601
86JAK10.37693262
87BTK0.37260388
88MAP3K90.36214458
89PIM20.35960241
90JAK20.33502756
91GSK3A0.33372136
92ABL20.32510540
93PDK10.32368262
94AKT20.31976130
95CSF1R0.31306793
96SYK0.31279599
97SGK30.31097543
98MAP3K10.30952742
99PAK10.30815722
100CAMK2B0.30721524
101PDGFRA0.30466112
102DAPK20.30326717
103CDK190.29900199
104PRKCA0.28086840
105CSNK1A10.27985393
106BRAF0.24581248
107PRKACG0.23969685
108FGFR40.23694905
109CSK0.23651485
110TAOK30.23629093
111ARAF0.23365155
112PRKACA0.23204540
113ERBB40.23174980
114GRK10.20929071
115BCKDK0.20111977
116CDK60.19946232
117WNK10.19826485
118CDK120.18566519
119IRAK30.18319080
120CAMK2A0.17948851
121MAPKAPK20.17693910
122STK110.17212803
123IGF1R0.16750306
124LYN0.16480537
125IKBKE0.16265785
126PIM10.15565492
127ERBB30.15003154
128TBK10.14652979
129SRC0.14534740
130LCK0.14497521
131TYK20.14457159
132PRKCB0.14405651
133MAPK70.14051046
134LIMK10.12822523
135MELK0.12674919
136PRKCZ0.12075897
137CAMK2G0.11201017
138CHEK20.10843903
139STK240.10649666
140CDK70.09651753
141TYRO30.09379827

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.08351785
2Vitamin digestion and absorption_Homo sapiens_hsa049774.31486468
3Renin-angiotensin system_Homo sapiens_hsa046144.30245241
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.91079461
5Mineral absorption_Homo sapiens_hsa049783.85664408
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.56208722
7Bile secretion_Homo sapiens_hsa049762.46172920
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.43636361
9Galactose metabolism_Homo sapiens_hsa000522.41803630
10Sulfur metabolism_Homo sapiens_hsa009202.34368180
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.32519182
12Starch and sucrose metabolism_Homo sapiens_hsa005002.28779000
13Folate biosynthesis_Homo sapiens_hsa007902.24482040
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22084207
15Caffeine metabolism_Homo sapiens_hsa002322.21180545
16* Protein digestion and absorption_Homo sapiens_hsa049742.10950493
17Fructose and mannose metabolism_Homo sapiens_hsa000512.06714318
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04173935
19Glutathione metabolism_Homo sapiens_hsa004801.72810912
20Tryptophan metabolism_Homo sapiens_hsa003801.70571239
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.70398756
22Histidine metabolism_Homo sapiens_hsa003401.65567112
23PPAR signaling pathway_Homo sapiens_hsa033201.63774273
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60059323
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50359453
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50051856
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48400214
28Fatty acid degradation_Homo sapiens_hsa000711.44916436
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44758424
30Glycerolipid metabolism_Homo sapiens_hsa005611.41192377
31Butanoate metabolism_Homo sapiens_hsa006501.39900926
32Arginine biosynthesis_Homo sapiens_hsa002201.32710845
33Arginine and proline metabolism_Homo sapiens_hsa003301.24981731
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23376339
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20150117
36Pyruvate metabolism_Homo sapiens_hsa006201.18056341
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13426807
38Carbon metabolism_Homo sapiens_hsa012001.12472023
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08327684
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04855085
41beta-Alanine metabolism_Homo sapiens_hsa004101.04118028
42Sphingolipid metabolism_Homo sapiens_hsa006001.02519497
43Peroxisome_Homo sapiens_hsa041461.00689505
44Nitrogen metabolism_Homo sapiens_hsa009100.92073767
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89445702
46Propanoate metabolism_Homo sapiens_hsa006400.88444845
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83664938
48Pentose phosphate pathway_Homo sapiens_hsa000300.83260792
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82666332
50Biosynthesis of amino acids_Homo sapiens_hsa012300.74873754
51Fatty acid metabolism_Homo sapiens_hsa012120.73800761
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.71743902
53Thyroid hormone synthesis_Homo sapiens_hsa049180.70688662
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.68722737
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68153752
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66939121
57ABC transporters_Homo sapiens_hsa020100.65988213
58Selenocompound metabolism_Homo sapiens_hsa004500.62628420
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61567633
60Asthma_Homo sapiens_hsa053100.61403067
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55114741
62Lysine degradation_Homo sapiens_hsa003100.54808658
63Tight junction_Homo sapiens_hsa045300.52764258
64Arachidonic acid metabolism_Homo sapiens_hsa005900.52590084
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52262455
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49284648
67Metabolic pathways_Homo sapiens_hsa011000.43537439
68Allograft rejection_Homo sapiens_hsa053300.43004991
69Chemical carcinogenesis_Homo sapiens_hsa052040.40356627
70Autoimmune thyroid disease_Homo sapiens_hsa053200.38614394
71Tyrosine metabolism_Homo sapiens_hsa003500.37835615
72Renin secretion_Homo sapiens_hsa049240.37418142
73Linoleic acid metabolism_Homo sapiens_hsa005910.37047677
74Graft-versus-host disease_Homo sapiens_hsa053320.36435971
75Retinol metabolism_Homo sapiens_hsa008300.35396165
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.35110855
77Pancreatic secretion_Homo sapiens_hsa049720.28996130
78Cocaine addiction_Homo sapiens_hsa050300.27652541
79Gastric acid secretion_Homo sapiens_hsa049710.26645217
80Type I diabetes mellitus_Homo sapiens_hsa049400.22670985
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.22491747
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22275387
83Other glycan degradation_Homo sapiens_hsa005110.21851170
84Staphylococcus aureus infection_Homo sapiens_hsa051500.21511636
85Glucagon signaling pathway_Homo sapiens_hsa049220.21401344
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.19511275
87Hepatitis C_Homo sapiens_hsa051600.19038075
88Serotonergic synapse_Homo sapiens_hsa047260.18548201
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18327600
90Bladder cancer_Homo sapiens_hsa052190.18307210
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.17541055
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16240341
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14822069
94Ether lipid metabolism_Homo sapiens_hsa005650.14219828
95Amphetamine addiction_Homo sapiens_hsa050310.12088801
96Inositol phosphate metabolism_Homo sapiens_hsa005620.11288241
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11224568
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.11138212
99Phenylalanine metabolism_Homo sapiens_hsa003600.11060284
100Fatty acid biosynthesis_Homo sapiens_hsa000610.10621872
101Type II diabetes mellitus_Homo sapiens_hsa049300.10567726
102Insulin secretion_Homo sapiens_hsa049110.10534832
103Collecting duct acid secretion_Homo sapiens_hsa049660.08757433
104Steroid biosynthesis_Homo sapiens_hsa001000.07847270
105Antigen processing and presentation_Homo sapiens_hsa046120.07235162
106Choline metabolism in cancer_Homo sapiens_hsa052310.07049844
107Thyroid cancer_Homo sapiens_hsa052160.06919147
108Vibrio cholerae infection_Homo sapiens_hsa051100.05840599
109AMPK signaling pathway_Homo sapiens_hsa041520.05357785
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.04546348
111Adherens junction_Homo sapiens_hsa045200.02821811
112Sulfur relay system_Homo sapiens_hsa041220.01987585
113Leishmaniasis_Homo sapiens_hsa051400.01858029
114Ovarian steroidogenesis_Homo sapiens_hsa049130.01578498
115Insulin resistance_Homo sapiens_hsa049310.01195472
116Salmonella infection_Homo sapiens_hsa051320.00281787
117Purine metabolism_Homo sapiens_hsa00230-0.0590370
118Fatty acid elongation_Homo sapiens_hsa00062-0.0486213
119African trypanosomiasis_Homo sapiens_hsa05143-0.0402146
120Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0369328
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0338759
122Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0316726
123Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0177377
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0157788
125Gap junction_Homo sapiens_hsa04540-0.0089758
126GnRH signaling pathway_Homo sapiens_hsa04912-0.0020940

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