MEPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* biomineral tissue development (GO:0031214)9.54588447
2tooth mineralization (GO:0034505)9.43618447
3cell aggregation (GO:0098743)9.32252081
4cartilage condensation (GO:0001502)9.32252081
5response to vitamin D (GO:0033280)9.28333569
6skin morphogenesis (GO:0043589)8.17091221
7bone mineralization (GO:0030282)8.13372143
8replacement ossification (GO:0036075)8.12996076
9endochondral ossification (GO:0001958)8.12996076
10positive regulation of epidermal cell differentiation (GO:0045606)7.82701345
11osteoblast development (GO:0002076)7.80024519
12collagen fibril organization (GO:0030199)7.48400350
13cellular response to nutrient (GO:0031670)7.27414033
14thrombin receptor signaling pathway (GO:0070493)6.97920951
15bone trabecula formation (GO:0060346)6.87268960
16decidualization (GO:0046697)6.61975715
17keratan sulfate metabolic process (GO:0042339)6.39901071
18positive regulation of receptor internalization (GO:0002092)6.37205454
19collagen catabolic process (GO:0030574)6.11470306
20collagen metabolic process (GO:0032963)5.93015511
21keratan sulfate catabolic process (GO:0042340)5.91106060
22regulation of extracellular matrix disassembly (GO:0010715)5.71930100
23multicellular organismal catabolic process (GO:0044243)5.65096092
24multicellular organismal macromolecule metabolic process (GO:0044259)5.59666316
25negative regulation of BMP signaling pathway (GO:0030514)5.41658808
26ossification (GO:0001503)5.35179806
27regulation of alkaline phosphatase activity (GO:0010692)5.29470204
28multicellular organismal metabolic process (GO:0044236)5.27731648
29sequestering of extracellular ligand from receptor (GO:0035581)5.24901244
30positive regulation of epidermis development (GO:0045684)5.19467893
31osteoblast differentiation (GO:0001649)5.18838085
32phosphate ion transmembrane transport (GO:0035435)5.11530965
33bone morphogenesis (GO:0060349)4.67679443
34chondrocyte development (GO:0002063)4.67013331
35response to testosterone (GO:0033574)4.61457074
36peptidyl-proline hydroxylation (GO:0019511)4.48486276
37response to parathyroid hormone (GO:0071107)4.45124271
38regulation of bone resorption (GO:0045124)4.42911520
39regulation of receptor internalization (GO:0002090)4.42355641
40adhesion of symbiont to host cell (GO:0044650)4.40564346
41virion attachment to host cell (GO:0019062)4.40564346
42mesenchymal-epithelial cell signaling (GO:0060638)4.36917910
43extracellular matrix disassembly (GO:0022617)4.35291011
44embryonic viscerocranium morphogenesis (GO:0048703)4.33467514
45* regulation of biomineral tissue development (GO:0070167)4.31664047
46bone development (GO:0060348)4.29265952
47* regulation of bone mineralization (GO:0030500)4.28989218
48phosphate ion transport (GO:0006817)4.27307235
49cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.19069165
50import into cell (GO:0098657)4.12831186
51axon extension involved in axon guidance (GO:0048846)4.12317284
52neuron projection extension involved in neuron projection guidance (GO:1902284)4.12317284
53regulation of G0 to G1 transition (GO:0070316)4.10072192
54protein trimerization (GO:0070206)4.02480506
55positive regulation of collagen biosynthetic process (GO:0032967)3.98134664
56lymphangiogenesis (GO:0001946)3.89602823
57* regulation of bone remodeling (GO:0046850)3.85421228
58adhesion of symbiont to host (GO:0044406)3.84745165
59hematopoietic stem cell differentiation (GO:0060218)3.81737674
60positive regulation of collagen metabolic process (GO:0010714)3.77472399
61negative regulation of glycogen biosynthetic process (GO:0045719)3.72382337
62endodermal cell differentiation (GO:0035987)3.69214075
63response to zinc ion (GO:0010043)3.68912679
64* negative regulation of ossification (GO:0030279)3.67594300
65chondrocyte proliferation (GO:0035988)3.66209402
66positive regulation of cardiac muscle cell differentiation (GO:2000727)3.63538809
67regulation of epidermal cell differentiation (GO:0045604)3.61956025
68substrate-dependent cell migration (GO:0006929)3.59981608
69aminoglycan catabolic process (GO:0006026)3.59560962
70bone resorption (GO:0045453)3.56267674
71regulation of BMP signaling pathway (GO:0030510)3.54439472
72anion homeostasis (GO:0055081)3.53530612
73extracellular matrix organization (GO:0030198)3.53475094
74extracellular structure organization (GO:0043062)3.52135990
75negative regulation of canonical Wnt signaling pathway (GO:0090090)3.51596668
76C4-dicarboxylate transport (GO:0015740)3.51363564
77COPI coating of Golgi vesicle (GO:0048205)3.51294010
78Golgi transport vesicle coating (GO:0048200)3.51294010
79negative regulation of JNK cascade (GO:0046329)3.51115504
80tissue remodeling (GO:0048771)3.45638912
81platelet dense granule organization (GO:0060155)3.43637675
82cellular response to amino acid stimulus (GO:0071230)3.41752457
83protein retention in ER lumen (GO:0006621)3.39884930
84protein hydroxylation (GO:0018126)3.39613679
85mitotic cell cycle arrest (GO:0071850)3.35773309
86anterior/posterior axis specification, embryo (GO:0008595)3.35769343
87regulation of collagen biosynthetic process (GO:0032965)3.27146036
88regulation of transforming growth factor beta2 production (GO:0032909)3.25842241
89positive regulation of receptor-mediated endocytosis (GO:0048260)3.25228048
90iron ion import (GO:0097286)3.24784384
91regulation of fibrinolysis (GO:0051917)3.23723463
92regulation of sarcomere organization (GO:0060297)3.23210703
93positive regulation of catenin import into nucleus (GO:0035413)3.21280117
94maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17328088
95vasculature development (GO:0001944)3.17299257
96negative regulation of stress-activated MAPK cascade (GO:0032873)3.14323508
97negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)3.14323508
98* skeletal system development (GO:0001501)3.14042265
99extracellular negative regulation of signal transduction (GO:1900116)3.11453917
100extracellular regulation of signal transduction (GO:1900115)3.11453917
101craniofacial suture morphogenesis (GO:0097094)3.08595900
102pathway-restricted SMAD protein phosphorylation (GO:0060389)3.06012703
103positive regulation of muscle hypertrophy (GO:0014742)3.04291817
104positive regulation of cardiac muscle hypertrophy (GO:0010613)3.04291817
105negative regulation of protein autophosphorylation (GO:0031953)3.03614135
106secondary heart field specification (GO:0003139)3.02788309
107heart field specification (GO:0003128)3.02788309
108positive regulation of Rho protein signal transduction (GO:0035025)3.01389830
109phagocytosis, recognition (GO:0006910)3.00226730
110response to vitamin (GO:0033273)3.00140057
111negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.99578767
112positive regulation of cell-substrate adhesion (GO:0010811)2.99541739
113regulation of extracellular matrix organization (GO:1903053)2.99123971
114regulation of tight junction assembly (GO:2000810)2.96999879
115positive regulation of protein homodimerization activity (GO:0090073)2.95348664
116blood vessel maturation (GO:0001955)2.94409827
117cartilage morphogenesis (GO:0060536)2.93417944
118regulation of collagen metabolic process (GO:0010712)2.92564784
119negative regulation of hormone biosynthetic process (GO:0032353)2.90467945
120peptidyl-glutamic acid carboxylation (GO:0017187)2.89682047
121protein carboxylation (GO:0018214)2.89682047
122extracellular matrix assembly (GO:0085029)2.89062165
123germinal center formation (GO:0002467)2.87704107
124glycosaminoglycan biosynthetic process (GO:0006024)2.86833117
125cartilage development (GO:0051216)2.85536397
126negative regulation of glycogen metabolic process (GO:0070874)2.84245564
127positive regulation of stem cell differentiation (GO:2000738)2.84115388
128negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.83575647
129mitochondrial genome maintenance (GO:0000002)2.82986879
130aminoglycan biosynthetic process (GO:0006023)2.82964195
131cell morphogenesis involved in neuron differentiation (GO:0048667)2.80988742
132regulation of fever generation (GO:0031620)2.79826179
133regulation of epidermis development (GO:0045682)2.77438693
134glomerular filtration (GO:0003094)2.76888569
135positive regulation of multicellular organismal metabolic process (GO:0044253)2.73446637
136positive regulation of phosphatase activity (GO:0010922)2.70967084
137regulation of execution phase of apoptosis (GO:1900117)2.70132497
138negative regulation of cell fate specification (GO:0009996)2.69851758
139extracellular fibril organization (GO:0043206)2.66645750
140cranial suture morphogenesis (GO:0060363)2.64010798
141* regulation of tissue remodeling (GO:0034103)2.63752236
142sulfur compound catabolic process (GO:0044273)2.60458309
143peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.59476141
144response to activity (GO:0014823)2.55584863
145negative regulation of chondrocyte differentiation (GO:0032331)2.55483893
146camera-type eye morphogenesis (GO:0048593)2.55100520
147positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54382115
148dermatan sulfate biosynthetic process (GO:0030208)2.51922202
149cellular response to prostaglandin stimulus (GO:0071379)2.51842985
150COPII vesicle coating (GO:0048208)2.47151111
151positive regulation of fatty acid beta-oxidation (GO:0032000)2.46807632
152positive regulation of osteoblast proliferation (GO:0033690)2.46285842
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45895076
154keratan sulfate biosynthetic process (GO:0018146)2.44205357
155peptidyl-proline modification (GO:0018208)2.41699992
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41454761
157glycosaminoglycan catabolic process (GO:0006027)2.39850860
158trabecula formation (GO:0060343)2.39483914
159negative regulation of interleukin-1 production (GO:0032692)2.39344587
160apoptotic cell clearance (GO:0043277)2.39056200
161* regulation of ossification (GO:0030278)2.38059318
162negative regulation of embryonic development (GO:0045992)2.37084177
163cellular response to vitamin D (GO:0071305)17.6823762
164cellular response to vitamin (GO:0071295)14.2759131
165response to gravity (GO:0009629)13.9038615
166trivalent inorganic anion homeostasis (GO:0072506)13.1318760
167phosphate ion homeostasis (GO:0055062)13.1318760
168protein heterotrimerization (GO:0070208)11.3636699
169response to phenylpropanoid (GO:0080184)10.2048296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.21978063
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human5.23936421
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19199531
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.06311600
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.00960433
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.81651361
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.54264379
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.95389602
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60037228
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.40043262
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38602031
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32429804
13CLOCK_20551151_ChIP-Seq_293T_Human2.14329325
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08982273
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.04010658
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00808306
17CJUN_26792858_Chip-Seq_BT549_Human1.94117578
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92413392
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92413392
20CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.91426651
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89340631
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88987896
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88431052
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.88174208
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87824036
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86019535
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86019535
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86019535
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.84759255
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84682882
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80793342
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77115266
33DROSHA_22980978_ChIP-Seq_HELA_Human1.76747358
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.75945326
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75939593
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74536621
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73937660
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72980028
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70568765
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68390970
41* P300_19829295_ChIP-Seq_ESCs_Human1.66357795
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65403158
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65181719
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65181719
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.58227840
46HTT_18923047_ChIP-ChIP_STHdh_Human1.56583022
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55875432
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54760903
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53496165
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49144121
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48917877
52SMAD4_21799915_ChIP-Seq_A2780_Human1.43967188
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.43035813
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42561313
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41858292
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41779088
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41364615
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40094393
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38957190
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37390734
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33253543
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32489559
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.32250747
64SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32189613
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32051130
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31384923
67BRD4_25478319_ChIP-Seq_HGPS_Human1.31161198
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29127707
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28236434
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.26724940
71GATA1_22025678_ChIP-Seq_K562_Human1.26274518
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25881538
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25695560
74KDM2B_26808549_Chip-Seq_K562_Human1.23138317
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.22905700
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.22724366
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21946130
78TP63_23658742_ChIP-Seq_EP156T_Human1.21710050
79SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.21292875
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20567718
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20429060
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.18302163
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.17541195
84TP53_16413492_ChIP-PET_HCT116_Human1.15812183
85TP53_18474530_ChIP-ChIP_U2OS_Human1.15749765
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.13611330
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12685880
88LXR_22292898_ChIP-Seq_THP-1_Human1.12524364
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.12254819
90* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11516588
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11195513
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09408345
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.08001852
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.07358628
95P53_22387025_ChIP-Seq_ESCs_Mouse1.07214661
96* TP53_20018659_ChIP-ChIP_R1E_Mouse1.07095012
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06884141
98TAF15_26573619_Chip-Seq_HEK293_Human1.06057790
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05144333
100SA1_22415368_ChIP-Seq_MEFs_Mouse1.03968413
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03779746
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.03171783
103STAT3_23295773_ChIP-Seq_U87_Human1.02999697
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.02984050
105GBX2_23144817_ChIP-Seq_PC3_Human1.02937015
106AHR_22903824_ChIP-Seq_MCF-7_Human1.02767546
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02591725
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01995110
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01224919
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01126468
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.00516105
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.00286269
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99295569
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99122409
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98211001
116CTCF_27219007_Chip-Seq_Bcells_Human0.97767022
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97600510
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.97184979
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.97184979
120CBP_20019798_ChIP-Seq_JUKART_Human0.96790734
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96790734
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96706872
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96685184
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96563044
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96401073
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96355559
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95865809
128SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95815699
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95703976
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95668752
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.95387369
132* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95281554
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94675950
134TCF4_23295773_ChIP-Seq_U87_Human0.94436185
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.94328784
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91891052
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.91615778
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.90999573
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.89768870
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.88878288
141SOX2_20726797_ChIP-Seq_SW620_Human0.88126788
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88009064
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87727041
144LXR_22158963_ChIP-Seq_LIVER_Mouse0.87047839
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86889274
146RXR_22108803_ChIP-Seq_LS180_Human0.86763503
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86698660
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86179596
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84748208
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83644358
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81725758
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.81473414
153TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80169186
154* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79743684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004185_abnormal_adipocyte_glucose9.03144173
2MP0008438_abnormal_cutaneous_collagen5.39190455
3MP0005083_abnormal_biliary_tract5.25689925
4MP0005503_abnormal_tendon_morphology4.95758005
5MP0005275_abnormal_skin_tensile3.88501472
6MP0005666_abnormal_adipose_tissue3.83745693
7* MP0002998_abnormal_bone_remodeling3.82656619
8* MP0002896_abnormal_bone_mineralization3.40115813
9MP0006054_spinal_hemorrhage3.17485262
10MP0005257_abnormal_intraocular_pressure2.58384005
11MP0005375_adipose_tissue_phenotype2.48450445
12MP0005084_abnormal_gallbladder_morpholo2.46613757
13MP0002115_abnormal_skeleton_extremities2.32124844
14MP0003279_aneurysm2.21658377
15MP0004019_abnormal_vitamin_homeostasis2.15436056
16MP0003718_maternal_effect2.11502515
17* MP0003795_abnormal_bone_structure2.07124951
18MP0001542_abnormal_bone_strength10.5033601
19MP0000569_abnormal_digit_pigmentation1.99757169
20MP0010368_abnormal_lymphatic_system1.93419684
21MP0002108_abnormal_muscle_morphology1.88175127
22MP0003646_muscle_fatigue1.79911810
23MP0004272_abnormal_basement_membrane1.76139865
24MP0005508_abnormal_skeleton_morphology1.72065933
25MP0002113_abnormal_skeleton_development1.70928351
26MP0002295_abnormal_pulmonary_circulatio1.70200613
27MP0009250_abnormal_appendicular_skeleto1.68003846
28MP0009384_cardiac_valve_regurgitation1.67952499
29MP0005365_abnormal_bile_salt1.65410871
30MP0000163_abnormal_cartilage_morphology1.63979178
31MP0001664_abnormal_digestion1.62553486
32MP0003183_abnormal_peptide_metabolism1.60392808
33* MP0001533_abnormal_skeleton_physiology1.54406295
34MP0004510_myositis1.49706298
35MP0009115_abnormal_fat_cell1.47894939
36* MP0005390_skeleton_phenotype1.45710488
37MP0005023_abnormal_wound_healing1.36088197
38MP0001958_emphysema1.34099584
39MP0000751_myopathy1.33944989
40MP0003705_abnormal_hypodermis_morpholog1.32784182
41MP0001666_abnormal_nutrient_absorption1.32531016
42MP0005085_abnormal_gallbladder_physiolo1.32224477
43MP0000013_abnormal_adipose_tissue1.30168581
44MP0001879_abnormal_lymphatic_vessel1.27211255
45MP0003195_calcinosis1.27033443
46MP0002109_abnormal_limb_morphology1.20861304
47MP0005623_abnormal_meninges_morphology1.19483873
48MP0001243_abnormal_dermal_layer1.18737804
49MP0003566_abnormal_cell_adhesion1.11677415
50MP0005448_abnormal_energy_balance1.09645591
51MP0005076_abnormal_cell_differentiation1.08586983
52MP0002060_abnormal_skin_morphology1.08048105
53MP0001765_abnormal_ion_homeostasis1.01707712
54MP0003890_abnormal_embryonic-extraembry1.00627472
55MP0002089_abnormal_postnatal_growth/wei0.99465208
56MP0001299_abnormal_eye_distance/0.93903246
57MP0004134_abnormal_chest_morphology0.92452416
58MP0001944_abnormal_pancreas_morphology0.90915610
59MP0002163_abnormal_gland_morphology0.90106134
60MP0005187_abnormal_penis_morphology0.88107066
61MP0002233_abnormal_nose_morphology0.79821695
62MP0004859_abnormal_synaptic_plasticity0.78944638
63MP0003868_abnormal_feces_composition0.76329977
64MP0002116_abnormal_craniofacial_bone0.76058264
65MP0005164_abnormal_response_to0.75520886
66MP0009780_abnormal_chondrocyte_physiolo0.72749459
67MP0000432_abnormal_head_morphology0.70437178
68MP0002282_abnormal_trachea_morphology0.68185285
69MP0005636_abnormal_mineral_homeostasis0.67394309
70MP0010386_abnormal_urinary_bladder0.66845285
71MP0003935_abnormal_craniofacial_develop0.65277064
72MP0001915_intracranial_hemorrhage0.64767992
73MP0002877_abnormal_melanocyte_morpholog0.62578748
74MP0009278_abnormal_bone_marrow0.60698865
75MP0002837_dystrophic_cardiac_calcinosis0.60240306
76MP0004084_abnormal_cardiac_muscle0.59115939
77MP0010030_abnormal_orbit_morphology0.58841855
78MP0000003_abnormal_adipose_tissue0.58063922
79MP0002933_joint_inflammation0.57883095
80MP0003385_abnormal_body_wall0.55490247
81MP0004924_abnormal_behavior0.53922315
82MP0005386_behavior/neurological_phenoty0.53922315
83MP0002932_abnormal_joint_morphology0.53798405
84MP0005379_endocrine/exocrine_gland_phen0.52876890
85MP0000462_abnormal_digestive_system0.51485361
86MP0002111_abnormal_tail_morphology0.47726613
87MP0002177_abnormal_outer_ear0.46598697
88MP0003300_gastrointestinal_ulcer0.46563140
89MP0001849_ear_inflammation0.46058576
90MP0003283_abnormal_digestive_organ0.45069842
91MP0002693_abnormal_pancreas_physiology0.44925273
92MP0002168_other_aberrant_phenotype0.44742895
93MP0005369_muscle_phenotype0.44735759
94MP0000604_amyloidosis0.43727361
95MP0005621_abnormal_cell_physiology0.43513493
96MP0003959_abnormal_lean_body0.43390971
97MP0002114_abnormal_axial_skeleton0.42894602
98MP0003045_fibrosis0.42687724
99MP0004858_abnormal_nervous_system0.42176843
100MP0000026_abnormal_inner_ear0.41694866
101MP0001731_abnormal_postnatal_growth0.41488555
102MP0000749_muscle_degeneration0.41393931
103MP0002876_abnormal_thyroid_physiology0.41226664
104MP0005248_abnormal_Harderian_gland0.41076863
105MP0000762_abnormal_tongue_morphology0.40501876
106MP0000733_abnormal_muscle_development0.38489815
107MP0003091_abnormal_cell_migration0.38477034
108MP0000358_abnormal_cell_content/0.37285255
109MP0002254_reproductive_system_inflammat0.36076445
110MP0000681_abnormal_thyroid_gland0.35596129
111MP0001919_abnormal_reproductive_system0.35530310
112MP0001286_abnormal_eye_development0.35018972
113MP0002249_abnormal_larynx_morphology0.34999815
114MP0003937_abnormal_limbs/digits/tail_de0.34499662
115MP0003956_abnormal_body_size0.33211778
116MP0005452_abnormal_adipose_tissue0.33197796
117MP0000428_abnormal_craniofacial_morphol0.33031471
118MP0003941_abnormal_skin_development0.32742051
119MP0003115_abnormal_respiratory_system0.32206118
120MP0000465_gastrointestinal_hemorrhage0.31504912
121MP0005165_increased_susceptibility_to0.31501580
122MP0000343_altered_response_to0.30777551
123MP0000049_abnormal_middle_ear0.29833331
124MP0003948_abnormal_gas_homeostasis0.29606522
125MP0001963_abnormal_hearing_physiology0.29559200
126MP0004036_abnormal_muscle_relaxation0.28501307
127MP0004885_abnormal_endolymph0.28404324
128MP0001177_atelectasis0.28228497
129MP0001346_abnormal_lacrimal_gland0.27013590
130MP0003252_abnormal_bile_duct0.26556368
131MP0003755_abnormal_palate_morphology0.25162549
132MP0000537_abnormal_urethra_morphology0.24608691
133MP0002128_abnormal_blood_circulation0.24397640
134MP0000767_abnormal_smooth_muscle0.24064801
135MP0004883_abnormal_blood_vessel0.23168977
136MP0004133_heterotaxia0.22668626
137MP0005220_abnormal_exocrine_pancreas0.22307837
138MP0005595_abnormal_vascular_smooth0.22087674
139MP0001614_abnormal_blood_vessel0.22083500
140MP0005395_other_phenotype0.21133260
141MP0004808_abnormal_hematopoietic_stem0.20808612
142MP0002118_abnormal_lipid_homeostasis0.18884246
143MP0000613_abnormal_salivary_gland0.18631534
144MP0003448_altered_tumor_morphology0.17579068
145MP0002332_abnormal_exercise_endurance0.17445859

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.19606132
2Metaphyseal cupping (HP:0003021)8.59408301
3Hypophosphatemic rickets (HP:0004912)7.80798418
4Premature rupture of membranes (HP:0001788)7.04985575
5Facial diplegia (HP:0001349)6.46647336
6Biconcave vertebral bodies (HP:0004586)6.34078388
7Small epiphyses (HP:0010585)5.94897218
8Ulnar bowing (HP:0003031)5.91580164
9Papilledema (HP:0001085)5.65069762
10Wormian bones (HP:0002645)5.34315974
11Abnormality of dentin (HP:0010299)5.24076058
12Enlarged epiphyses (HP:0010580)5.17992283
13Tibial bowing (HP:0002982)4.89192896
14Femoral bowing (HP:0002980)4.84231908
15Neonatal short-limb short stature (HP:0008921)4.80162558
16Peritonitis (HP:0002586)4.65152419
17Rickets (HP:0002748)4.60691889
18Osteomalacia (HP:0002749)4.58167168
19Cupped ribs (HP:0000887)4.44710302
20Sudden death (HP:0001699)4.33630464
21Atrophic scars (HP:0001075)4.31685759
22Soft skin (HP:0000977)4.30179064
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.97559840
24Flattened epiphyses (HP:0003071)3.91182550
25Radial bowing (HP:0002986)3.90559759
26Breech presentation (HP:0001623)3.88234720
27Vertebral compression fractures (HP:0002953)3.86081351
28Blue sclerae (HP:0000592)3.82932690
29Abnormality of the vertebral endplates (HP:0005106)3.79721682
30Irregular vertebral endplates (HP:0003301)3.74943822
31Bowed forearm bones (HP:0003956)3.71900001
32Bowing of the arm (HP:0006488)3.71900001
33Nonimmune hydrops fetalis (HP:0001790)3.57460982
34Flared iliac wings (HP:0002869)3.54776859
35Decreased skull ossification (HP:0004331)3.52861471
36Osteoarthritis (HP:0002758)3.51869559
37Coxa vara (HP:0002812)3.38843292
38Genu recurvatum (HP:0002816)3.34120143
39Elevated alkaline phosphatase (HP:0003155)3.28775648
40Constricted visual fields (HP:0001133)3.25435866
41Aortic dissection (HP:0002647)3.20674923
42Morphological abnormality of the middle ear (HP:0008609)3.19392633
43Mild short stature (HP:0003502)3.18901731
44Abnormality of skull ossification (HP:0002703)3.16402802
45Platyspondyly (HP:0000926)3.13657147
46Bladder diverticulum (HP:0000015)3.08659751
47Broad metatarsal (HP:0001783)3.06526244
48Flared metaphyses (HP:0003015)2.98337597
49Metaphyseal irregularity (HP:0003025)2.96768557
50Abnormal delivery (HP:0001787)2.91126598
51Fragile skin (HP:0001030)2.89041411
52Infantile muscular hypotonia (HP:0008947)2.80938642
53Absent frontal sinuses (HP:0002688)2.74954084
54Abnormality of the costochondral junction (HP:0000919)2.72333670
55Ankle contracture (HP:0006466)2.71921877
56Hypophosphatemia (HP:0002148)2.71714001
57Persistence of primary teeth (HP:0006335)2.67189951
58Shallow orbits (HP:0000586)2.65987848
59Broad ribs (HP:0000885)2.64581353
60Increased density of long bones (HP:0006392)2.64366203
61Vertebral clefting (HP:0008428)2.60682300
62Short middle phalanx of finger (HP:0005819)2.60650426
63Abnormality of calcium-phosphate metabolism (HP:0100530)2.58955135
64Widely patent fontanelles and sutures (HP:0004492)2.58510418
65Wide cranial sutures (HP:0010537)2.55988277
66Craniofacial hyperostosis (HP:0004493)2.53602638
67Cervical subluxation (HP:0003308)2.52906170
68Hyperextensible skin (HP:0000974)2.51106813
69Wide anterior fontanel (HP:0000260)2.48736385
70Mitral valve prolapse (HP:0001634)2.39434340
71Spinal cord compression (HP:0002176)2.37114351
72Abnormality of the acetabulum (HP:0003170)2.36816391
73Follicular hyperkeratosis (HP:0007502)2.36243121
74Rhizomelia (HP:0008905)2.36109515
75Abnormality of the epiphysis of the femoral head (HP:0010574)2.29659867
76Arthropathy (HP:0003040)2.26912478
77Osteolytic defects of the hand bones (HP:0009699)2.24849619
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.24849619
79Choanal stenosis (HP:0000452)2.23566697
80Bowel diverticulosis (HP:0005222)2.22085761
81Progressive visual loss (HP:0000529)2.21403082
82Osteopenia (HP:0000938)2.17709283
83Abnormality of alkaline phosphatase activity (HP:0004379)2.16405176
84Abnormal enzyme/coenzyme activity (HP:0012379)2.11641877
85Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.11380491
86Abnormality of femoral epiphyses (HP:0006499)2.11380491
87Spondylolisthesis (HP:0003302)2.11123467
88Genu varum (HP:0002970)2.10806476
89Abnormality of the femoral head (HP:0003368)2.10550790
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09776533
91Deviation of the hallux (HP:0010051)2.08916553
92Hallux valgus (HP:0001822)2.07305005
93Bell-shaped thorax (HP:0001591)2.05797731
94Delayed closure of the anterior fontanelle (HP:0001476)2.05718875
95Limited elbow extension (HP:0001377)2.03962065
96Abnormality of the ischium (HP:0003174)2.03531684
97Abnormality of the peritoneum (HP:0002585)2.03395256
98Abnormal vertebral ossification (HP:0100569)2.02852806
99Spinal canal stenosis (HP:0003416)2.02735365
100Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.01136522
101Cranial hyperostosis (HP:0004437)1.96987053
102Hypoplastic ischia (HP:0003175)1.95647976
103Abnormal cortical bone morphology (HP:0003103)1.94688855
104Midface retrusion (HP:0011800)1.93331335
105Overgrowth (HP:0001548)1.92952275
106Dilatation of the ascending aorta (HP:0005111)1.91653425
107Waddling gait (HP:0002515)1.90820571
108Slender long bone (HP:0003100)1.89467397
109Metaphyseal dysplasia (HP:0100255)1.87278805
110Abnormality of the frontal sinuses (HP:0002687)1.85089636
111Delayed cranial suture closure (HP:0000270)1.84004668
112Esotropia (HP:0000565)1.81796266
113Joint laxity (HP:0001388)1.77639849
114Abnormality of the middle phalanges of the hand (HP:0009833)1.77639153
115Arterial tortuosity (HP:0005116)1.76236376
116Prominent supraorbital ridges (HP:0000336)1.76206245
117Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75597309
118Abnormality of Sharpey fibers (HP:0100685)1.75147059
119Pathologic fracture (HP:0002756)1.73799571
120Abnormality of primary teeth (HP:0006481)1.72728199
121Carpal bone hypoplasia (HP:0001498)1.71694488
122Bone pain (HP:0002653)1.67565938
123Abnormal cartilage morphology (HP:0002763)1.56468772
124Vascular tortuosity (HP:0004948)1.55431098
125Broad phalanges of the hand (HP:0009768)1.47073691
126Hypercalcemia (HP:0003072)1.45058298
127Increased intracranial pressure (HP:0002516)1.44760246
128Abnormality of intracranial pressure (HP:0012640)1.44760246
129Abnormal urine phosphate concentration (HP:0012599)1.44515819
130Mixed hearing impairment (HP:0000410)1.42403328
131Cardiovascular calcification (HP:0011915)1.41800847
132Atresia of the external auditory canal (HP:0000413)1.38971093
133Broad phalanx (HP:0006009)1.38220936
134Broad finger (HP:0001500)1.37629624
135Vascular calcification (HP:0004934)1.34923862
136Broad long bones (HP:0005622)1.31366946
137Beaking of vertebral bodies (HP:0004568)1.22345843
138Chondrocalcinosis (HP:0000934)1.20902667
139Delayed epiphyseal ossification (HP:0002663)1.15036433
140Short distal phalanx of finger (HP:0009882)1.13930038
141Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.12488932
142Abnormality of the intervertebral disk (HP:0005108)1.11846957
143Spinal cord lesions (HP:0100561)1.10907047
144Syringomyelia (HP:0003396)1.10907047
145Abnormality of the fibula (HP:0002991)1.07154716
146Dental malocclusion (HP:0000689)1.06789266
147Mandibular prognathia (HP:0000303)1.03086106
148Renal tubular dysfunction (HP:0000124)1.00850367
149Aortic aneurysm (HP:0004942)1.00418693
150Hypoplasia of the odontoid process (HP:0003311)1.00040311
151Ulnar deviation of the wrist (HP:0003049)0.94707665
152Limited hip movement (HP:0008800)0.94372503
153Absent hand (HP:0004050)0.91511173
154Short middle phalanx of the 5th finger (HP:0004220)0.90470444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.89939070
2SIK14.51710361
3NTRK23.69347788
4PNCK3.58187207
5TRIB33.47236696
6TNIK3.39152120
7MST43.30011166
8NLK3.28305589
9CCNB12.67987414
10PKN22.45172805
11FGFR22.26581536
12PDGFRA2.13570768
13DDR210.0675699
14ERN11.94866511
15MAP3K91.93830520
16RIPK11.85005894
17TAF11.83838819
18MAP3K131.81026978
19EPHB21.77871506
20AKT31.76276909
21NTRK31.70964423
22ARAF1.58913238
23SGK21.58332856
24STK241.56379148
25WNK11.52243722
26NTRK11.49524332
27CASK1.44837013
28CSF1R1.42098979
29FGFR11.37817945
30ERBB41.31930774
31MET1.31053353
32NME21.29819141
33TTN1.26302349
34BMX1.25806583
35LATS21.25317586
36TGFBR21.24300573
37LATS11.24052654
38FER1.21046784
39LRRK21.20504401
40PTK61.18592444
41CDK81.17084372
42MAP3K41.10895388
43DMPK1.10086376
44MAPK121.07137169
45PIM21.07100299
46MAP3K21.04469033
47PAK41.00657119
48FLT31.00430007
49PLK20.99071902
50PAK20.99031584
51SGK30.97851751
52PAK30.94626770
53MOS0.94467629
54EPHA20.92157406
55MELK0.91568079
56DAPK20.90645639
57SGK4940.86617044
58SGK2230.86617044
59JAK10.86191782
60STK100.84650261
61ROCK10.81853713
62MST1R0.80756691
63DYRK1B0.79503525
64ROCK20.79433532
65SCYL20.78910993
66EPHB10.77191469
67TRPM70.75302564
68STK38L0.74291005
69RET0.71797444
70PTK20.71442959
71PKN10.71415175
72CDK60.71071100
73EIF2AK30.70123276
74CAMKK10.69189108
75STK390.64954963
76PRKCG0.63045272
77PDGFRB0.61052852
78MAPK70.60978706
79PRKCE0.60779677
80PIK3CA0.59968755
81PRKCH0.59165656
82WNK40.58967704
83IGF1R0.58773835
84PDK20.57658963
85MYLK0.57657506
86PAK60.57425657
87PTK2B0.56359917
88ILK0.54956450
89MAPKAPK50.54296228
90MAPK100.53754497
91ADRBK10.52487452
92ALK0.52449377
93MAP3K120.52298476
94DAPK30.52036127
95BRAF0.49651503
96SRC0.49612620
97FGFR40.48486033
98ACVR1B0.47977933
99INSR0.47880415
100TEC0.47688694
101PRKG10.47650272
102MAPK40.47192745
103EEF2K0.45572172
104KSR20.45478555
105PRKCQ0.44638798
106PRKD10.44140340
107FYN0.43521460
108CSNK1A1L0.43408830
109LMTK20.43012262
110EIF2AK20.42590884
111FRK0.41762427
112BMPR1B0.41059207
113RAF10.39997701
114FGFR30.39688895
115TYRO30.38503485
116MAPK140.38188233
117LIMK10.37654425
118CDK90.36737713
119MAP2K10.36327854
120CSNK1G10.36223778
121TGFBR10.35894950
122PHKG10.34565019
123PHKG20.34565019
124TESK10.33911723
125GSK3A0.33873102
126CAMK10.32315776
127SIK20.32060512
128MTOR0.31873975
129PDPK10.31080969
130CSK0.30223842
131CSNK1G30.30185959
132MAP3K100.29711550
133PDK10.29052589
134DYRK30.28940383
135NEK90.27308810
136PRKAA20.26024187
137ABL10.25896598
138SGK10.25373363
139KSR10.23837267
140NUAK10.23446533
141EPHA40.23162778
142EGFR0.22951480
143CAMKK20.22936919
144ABL20.22925635
145MAP2K40.22830736
146CSNK1G20.22818346
147IKBKB0.22733767
148CDK50.22711831
149ERBB30.22706734
150CAMK1D0.22531386
151UHMK10.22241104
152PIK3CG0.21966298
153MAPK30.21865997
154STK30.21613552
155PRKG20.20367087
156CAMK1G0.19690927

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.91903235
2Folate biosynthesis_Homo sapiens_hsa007904.94735504
3Protein digestion and absorption_Homo sapiens_hsa049744.61045681
4Focal adhesion_Homo sapiens_hsa045103.37221089
5Collecting duct acid secretion_Homo sapiens_hsa049663.15485239
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.05573766
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.07601218
8PI3K-Akt signaling pathway_Homo sapiens_hsa041512.02662905
9Bladder cancer_Homo sapiens_hsa052191.63410804
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62195072
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57286227
12Amoebiasis_Homo sapiens_hsa051461.56921744
13Proteoglycans in cancer_Homo sapiens_hsa052051.48640748
14Dilated cardiomyopathy_Homo sapiens_hsa054141.48460237
15Colorectal cancer_Homo sapiens_hsa052101.47289237
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42471075
17Wnt signaling pathway_Homo sapiens_hsa043101.42401336
18Prolactin signaling pathway_Homo sapiens_hsa049171.39954728
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36639708
20Sulfur metabolism_Homo sapiens_hsa009201.36343078
21Thyroid hormone synthesis_Homo sapiens_hsa049181.36334589
22Dorso-ventral axis formation_Homo sapiens_hsa043201.34366927
23Malaria_Homo sapiens_hsa051441.28410697
24MicroRNAs in cancer_Homo sapiens_hsa052061.27186443
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22899920
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16876678
27Melanogenesis_Homo sapiens_hsa049161.15644970
28Platelet activation_Homo sapiens_hsa046111.11617623
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11524563
30Cocaine addiction_Homo sapiens_hsa050301.11184694
31Axon guidance_Homo sapiens_hsa043601.10320718
32Estrogen signaling pathway_Homo sapiens_hsa049151.09558202
33Melanoma_Homo sapiens_hsa052181.09470118
34TGF-beta signaling pathway_Homo sapiens_hsa043501.08902288
35Basal cell carcinoma_Homo sapiens_hsa052171.06635597
36Renal cell carcinoma_Homo sapiens_hsa052111.05833937
37Prostate cancer_Homo sapiens_hsa052151.04287892
38Lysosome_Homo sapiens_hsa041421.03727125
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03031468
40Pancreatic secretion_Homo sapiens_hsa049721.01733673
41Vibrio cholerae infection_Homo sapiens_hsa051100.99643801
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99201818
43Circadian rhythm_Homo sapiens_hsa047100.96260389
44Thyroid cancer_Homo sapiens_hsa052160.93926207
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92348244
46Phagosome_Homo sapiens_hsa041450.89597231
47Glioma_Homo sapiens_hsa052140.88959972
48Synaptic vesicle cycle_Homo sapiens_hsa047210.87990955
49Rheumatoid arthritis_Homo sapiens_hsa053230.86744019
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.86716242
51Nitrogen metabolism_Homo sapiens_hsa009100.83694681
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82213469
53Adherens junction_Homo sapiens_hsa045200.79803418
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79293634
55Amphetamine addiction_Homo sapiens_hsa050310.76922694
56Chronic myeloid leukemia_Homo sapiens_hsa052200.76085279
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75076644
58Hippo signaling pathway_Homo sapiens_hsa043900.72977327
59Chemokine signaling pathway_Homo sapiens_hsa040620.71789804
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70559231
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69683503
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69224602
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68658350
64Calcium signaling pathway_Homo sapiens_hsa040200.68488421
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68409879
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67816506
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65242320
68ErbB signaling pathway_Homo sapiens_hsa040120.64646767
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63358614
70Gap junction_Homo sapiens_hsa045400.62408995
71Insulin resistance_Homo sapiens_hsa049310.62331846
72Rap1 signaling pathway_Homo sapiens_hsa040150.61905395
73Arginine and proline metabolism_Homo sapiens_hsa003300.60138155
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59653417
75Insulin secretion_Homo sapiens_hsa049110.59652938
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59403630
77Cholinergic synapse_Homo sapiens_hsa047250.58899276
78Bile secretion_Homo sapiens_hsa049760.58420522
79Osteoclast differentiation_Homo sapiens_hsa043800.57568687
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.56460444
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53011351
82Complement and coagulation cascades_Homo sapiens_hsa046100.52432301
83Endometrial cancer_Homo sapiens_hsa052130.52166628
84Pancreatic cancer_Homo sapiens_hsa052120.51391565
85FoxO signaling pathway_Homo sapiens_hsa040680.51110790
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51006473
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.50307581
88GnRH signaling pathway_Homo sapiens_hsa049120.48772520
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48352132
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47119362
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.46944852
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45806515
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43557478
94Dopaminergic synapse_Homo sapiens_hsa047280.41898208
95Olfactory transduction_Homo sapiens_hsa047400.41581769
96Gastric acid secretion_Homo sapiens_hsa049710.41009587
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.40192998
98cAMP signaling pathway_Homo sapiens_hsa040240.39014355
99Glucagon signaling pathway_Homo sapiens_hsa049220.39005135
100Arachidonic acid metabolism_Homo sapiens_hsa005900.38931552
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38747070
102Tuberculosis_Homo sapiens_hsa051520.38515290
103Renin-angiotensin system_Homo sapiens_hsa046140.38198575
104Other glycan degradation_Homo sapiens_hsa005110.37075692
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34357185
106Small cell lung cancer_Homo sapiens_hsa052220.34269508
107Pathways in cancer_Homo sapiens_hsa052000.33734775
108Renin secretion_Homo sapiens_hsa049240.33695463
109TNF signaling pathway_Homo sapiens_hsa046680.33584241
110Hepatitis B_Homo sapiens_hsa051610.32983658
111AMPK signaling pathway_Homo sapiens_hsa041520.32677737
112Hedgehog signaling pathway_Homo sapiens_hsa043400.32213234
113Staphylococcus aureus infection_Homo sapiens_hsa051500.32076130
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.31842528
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31798459
116Oxytocin signaling pathway_Homo sapiens_hsa049210.31091649
117Endocytosis_Homo sapiens_hsa041440.30789214
118Long-term potentiation_Homo sapiens_hsa047200.30605391
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.29849564
120Circadian entrainment_Homo sapiens_hsa047130.29237824
121Prion diseases_Homo sapiens_hsa050200.29126868
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28865641
123Choline metabolism in cancer_Homo sapiens_hsa052310.28838806
124VEGF signaling pathway_Homo sapiens_hsa043700.28756535
125Hematopoietic cell lineage_Homo sapiens_hsa046400.28509767
126N-Glycan biosynthesis_Homo sapiens_hsa005100.27322288
127Lysine degradation_Homo sapiens_hsa003100.27224529
128Starch and sucrose metabolism_Homo sapiens_hsa005000.27132575
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.26917818
130Ras signaling pathway_Homo sapiens_hsa040140.26543294
131Phenylalanine metabolism_Homo sapiens_hsa003600.26206701
132Butanoate metabolism_Homo sapiens_hsa006500.25443671
133GABAergic synapse_Homo sapiens_hsa047270.25099853
134Non-small cell lung cancer_Homo sapiens_hsa052230.24123416
135Protein export_Homo sapiens_hsa030600.23677000
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23315451
137MAPK signaling pathway_Homo sapiens_hsa040100.21850306
138Long-term depression_Homo sapiens_hsa047300.21817383
139beta-Alanine metabolism_Homo sapiens_hsa004100.20463245
140Acute myeloid leukemia_Homo sapiens_hsa052210.18489036
141Sphingolipid metabolism_Homo sapiens_hsa006000.17100308
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.15889418
143Viral myocarditis_Homo sapiens_hsa054160.15454979

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