MESDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.62196609
2NIK/NF-kappaB signaling (GO:0038061)4.60923818
3response to peptidoglycan (GO:0032494)4.49991097
4negative regulation of interleukin-12 production (GO:0032695)4.00747414
5lipopolysaccharide-mediated signaling pathway (GO:0031663)3.93698170
6regulation of integrin activation (GO:0033623)3.86210077
7negative regulation of erythrocyte differentiation (GO:0045647)3.62096084
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59012980
9regulation of vitamin metabolic process (GO:0030656)3.51072027
10viral transcription (GO:0019083)3.37759731
11signal complex assembly (GO:0007172)3.37285460
12myeloid dendritic cell differentiation (GO:0043011)3.37045339
13regulation of early endosome to late endosome transport (GO:2000641)3.36864497
14erythrocyte maturation (GO:0043249)3.36087614
15positive regulation of gamma-delta T cell activation (GO:0046645)3.31123403
16germinal center formation (GO:0002467)3.27511269
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23594041
18maternal placenta development (GO:0001893)3.23150296
19translational termination (GO:0006415)3.20548943
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.17816217
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.17816217
22modulation by symbiont of host immune response (GO:0052553)3.17816217
23positive regulation by symbiont of host defense response (GO:0052509)3.17816217
24modulation by symbiont of host defense response (GO:0052031)3.17816217
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.17816217
26regulation of T-helper 1 cell differentiation (GO:0045625)3.14803838
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.13274183
28protein localization to endosome (GO:0036010)3.12427734
29establishment of apical/basal cell polarity (GO:0035089)3.11052918
30negative regulation of cytokine production involved in immune response (GO:0002719)3.09959742
31response to muramyl dipeptide (GO:0032495)3.07832860
32regulation of NFAT protein import into nucleus (GO:0051532)3.07517142
33mannose metabolic process (GO:0006013)3.07445461
34heterochromatin organization (GO:0070828)3.05761892
35regulation of chemokine biosynthetic process (GO:0045073)3.03267547
36apoptotic cell clearance (GO:0043277)3.01555575
37myeloid dendritic cell activation (GO:0001773)2.99824265
38positive regulation of chemokine biosynthetic process (GO:0045080)2.97323269
39response to protozoan (GO:0001562)2.96995655
40production of molecular mediator involved in inflammatory response (GO:0002532)2.93564079
41positive regulation of type 2 immune response (GO:0002830)2.92333555
42regulation of mononuclear cell migration (GO:0071675)2.92106822
43regulation of interleukin-2 biosynthetic process (GO:0045076)2.91806761
44positive regulation of histone deacetylation (GO:0031065)2.91116818
45regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90249322
46basement membrane organization (GO:0071711)2.88949133
47apoptotic process involved in morphogenesis (GO:0060561)2.88513953
48regulation of protein heterodimerization activity (GO:0043497)2.88129308
49monocyte chemotaxis (GO:0002548)2.87027472
50protein localization to kinetochore (GO:0034501)2.86250819
513-UTR-mediated mRNA stabilization (GO:0070935)2.85576734
52cellular response to type I interferon (GO:0071357)2.85341647
53type I interferon signaling pathway (GO:0060337)2.85341647
54response to type I interferon (GO:0034340)2.84364512
55defense response to protozoan (GO:0042832)2.83550792
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82553755
57stress fiber assembly (GO:0043149)2.82245284
58modulation by symbiont of host cellular process (GO:0044068)2.79649882
59neutrophil activation involved in immune response (GO:0002283)2.79098683
60regulation of T-helper 2 cell differentiation (GO:0045628)2.78907330
61response to laminar fluid shear stress (GO:0034616)2.78438252
62negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.76855098
63translational elongation (GO:0006414)2.75421008
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75059912
65wound healing, spreading of epidermal cells (GO:0035313)2.74937199
66negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73899603
67CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73851871
68mRNA stabilization (GO:0048255)2.73474940
69RNA stabilization (GO:0043489)2.73474940
70positive regulation of SMAD protein import into nucleus (GO:0060391)2.71312202
71polarized epithelial cell differentiation (GO:0030859)2.69701077
72T cell migration (GO:0072678)2.69160605
73branching involved in labyrinthine layer morphogenesis (GO:0060670)2.67389448
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.67355469
75interferon-gamma-mediated signaling pathway (GO:0060333)2.67064006
76natural killer cell differentiation (GO:0001779)2.66917588
77leukocyte aggregation (GO:0070486)2.64160419
78positive regulation of Cdc42 GTPase activity (GO:0043089)2.63809255
79negative regulation of cell killing (GO:0031342)2.62908413
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62908413
81viral life cycle (GO:0019058)2.62226802
82regulation of interferon-alpha production (GO:0032647)2.62060001
83regulation of SMAD protein import into nucleus (GO:0060390)2.61615598
84regulation of fever generation (GO:0031620)2.60424797
85T cell apoptotic process (GO:0070231)2.59977486
86positive regulation of heat generation (GO:0031652)2.59849611
87negative regulation of adherens junction organization (GO:1903392)2.59120182
88negative regulation of focal adhesion assembly (GO:0051895)2.59120182
89negative regulation of cell junction assembly (GO:1901889)2.59120182
90trophectodermal cell differentiation (GO:0001829)2.59093627
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58933909
92negative regulation of viral release from host cell (GO:1902187)2.57802944
93activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.57801162
94establishment of endothelial barrier (GO:0061028)2.57412974
95embryonic process involved in female pregnancy (GO:0060136)2.55019523
96cellular response to lipopolysaccharide (GO:0071222)2.55009122
97positive regulation of isotype switching (GO:0045830)2.54378427
98pinocytosis (GO:0006907)2.53486203
99necroptotic process (GO:0070266)2.53044021
100translational initiation (GO:0006413)2.52999303
101megakaryocyte development (GO:0035855)2.51331997
102regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51300888
103cellular protein complex disassembly (GO:0043624)2.50754396
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50310508
105morphogenesis of an endothelium (GO:0003159)2.49936255
106endothelial tube morphogenesis (GO:0061154)2.49936255
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.48557885
108establishment of monopolar cell polarity (GO:0061162)2.48557885
109T-helper 1 type immune response (GO:0042088)2.47883929
110regulation of gamma-delta T cell activation (GO:0046643)2.47514407
111positive regulation of lamellipodium assembly (GO:0010592)2.47285925
112macrophage activation involved in immune response (GO:0002281)2.46573832
113regulation of cytokine secretion involved in immune response (GO:0002739)2.46120972
114regulation of necroptotic process (GO:0060544)2.45499568
115mRNA transcription (GO:0009299)2.44893245
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.44642907
117negative regulation of myeloid cell apoptotic process (GO:0033033)2.43880230
118cellular response to molecule of bacterial origin (GO:0071219)2.42892800
119regulation of lymphocyte migration (GO:2000401)2.42826904
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.41505933
121positive regulation of B cell mediated immunity (GO:0002714)2.41147882
122positive regulation of immunoglobulin mediated immune response (GO:0002891)2.41147882
123immunoglobulin mediated immune response (GO:0016064)2.40743187
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.40615214
125cellular response to thyroid hormone stimulus (GO:0097067)2.39738187
126cellular response to arsenic-containing substance (GO:0071243)2.39521459
127regulation of necrotic cell death (GO:0010939)2.39494554
128regulation of type 2 immune response (GO:0002828)2.38254810
129regulation of gene silencing by RNA (GO:0060966)2.37682500
130regulation of posttranscriptional gene silencing (GO:0060147)2.37682500
131regulation of gene silencing by miRNA (GO:0060964)2.37682500
132adherens junction assembly (GO:0034333)2.37563055
133protein targeting to ER (GO:0045047)2.37071964
134intracellular estrogen receptor signaling pathway (GO:0030520)2.36458887
135mitotic sister chromatid segregation (GO:0000070)2.36449745
136DNA unwinding involved in DNA replication (GO:0006268)2.36148695
137positive regulation of transcription factor import into nucleus (GO:0042993)2.36016818
138barbed-end actin filament capping (GO:0051016)2.35794400
139cellular extravasation (GO:0045123)2.35602256
140positive regulation of interferon-alpha production (GO:0032727)2.35080850
141positive regulation of lymphocyte apoptotic process (GO:0070230)2.34700380
142positive regulation of NF-kappaB import into nucleus (GO:0042346)2.34698932
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34641928
144positive thymic T cell selection (GO:0045059)2.34564769
145positive regulation of protein homooligomerization (GO:0032464)2.34518860
146cortical actin cytoskeleton organization (GO:0030866)2.33915788
147protein heterotrimerization (GO:0070208)2.33615642
148chromatin assembly (GO:0031497)2.33534590
149regulation of apoptotic process involved in morphogenesis (GO:1902337)2.33242198
150negative regulation of production of molecular mediator of immune response (GO:0002701)2.33102394
151protein complex disassembly (GO:0043241)2.33065191
152regulation of interferon-beta biosynthetic process (GO:0045357)2.32001906
153mitotic G1 DNA damage checkpoint (GO:0031571)2.31639409
154regulation of chronic inflammatory response (GO:0002676)2.31605611
155regulation of translational termination (GO:0006449)2.31423962
156glucocorticoid receptor signaling pathway (GO:0042921)2.30873069
157lymphocyte chemotaxis (GO:0048247)2.30783499
158cellular senescence (GO:0090398)2.29495970
159regulation of macrophage cytokine production (GO:0010935)2.29194642
160cotranslational protein targeting to membrane (GO:0006613)2.29096729
161protein localization to chromosome, centromeric region (GO:0071459)2.28530820
162sister chromatid segregation (GO:0000819)2.27312950
163negative regulation of fatty acid transport (GO:2000192)2.26326508
164regulation of translational fidelity (GO:0006450)2.26255380
165regulation of podosome assembly (GO:0071801)2.25898371
166positive regulation of nuclease activity (GO:0032075)2.24805634
167establishment of protein localization to endoplasmic reticulum (GO:0072599)2.24682851
168negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.24480419
169positive regulation of protein deacetylation (GO:0090312)2.23085076
170endodermal cell differentiation (GO:0035987)2.22857283
171cell-substrate junction assembly (GO:0007044)2.20837892
172regulation of erythrocyte differentiation (GO:0045646)2.20794588
173positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.19910463
174activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19686086
175negative regulation of glial cell proliferation (GO:0060253)2.19616569
176B cell mediated immunity (GO:0019724)2.19439706
177activation of MAPKKK activity (GO:0000185)2.19407192
178negative regulation of cell size (GO:0045792)2.18632504
179lymphocyte apoptotic process (GO:0070227)2.18058893
180cellular hyperosmotic response (GO:0071474)2.18037210
181regulation of p38MAPK cascade (GO:1900744)2.16440759
182nodal signaling pathway (GO:0038092)2.16255152
183pre-miRNA processing (GO:0031054)2.16200270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.13109468
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.73419129
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.49878744
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.44666904
5MYC_22102868_ChIP-Seq_BL_Human3.13907115
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72253430
7VDR_21846776_ChIP-Seq_THP-1_Human2.68685415
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.44567528
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.41936681
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28939619
11ZNF263_19887448_ChIP-Seq_K562_Human2.25140952
12KDM2B_26808549_Chip-Seq_DND41_Human2.18716194
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.11841933
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03626129
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83699382
16* LXR_22292898_ChIP-Seq_THP-1_Human1.80723766
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.80676740
18VDR_24763502_ChIP-Seq_THP-1_Human1.76881475
19* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74404422
20* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71543150
21* MAF_26560356_Chip-Seq_TH1_Human1.71058262
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69942445
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.69813874
24* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69778397
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68831408
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67750757
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67721397
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67688955
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.66319118
30* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64205950
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60648321
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60084225
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59286880
34* ATF3_27146783_Chip-Seq_COLON_Human1.58496457
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52316614
36UTX_26944678_Chip-Seq_JUKART_Human1.51751904
37* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51117153
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50895599
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50199506
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49172631
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46984013
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45367932
43* MYC_18555785_ChIP-Seq_MESCs_Mouse1.45065304
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44481379
45NCOR1_26117541_ChIP-Seq_K562_Human1.43861273
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43246509
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43041981
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42369713
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42288032
50KDM2B_26808549_Chip-Seq_K562_Human1.40821883
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40119268
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39749197
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39749197
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39749197
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38968485
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37336903
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.36504524
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35931027
59* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34641488
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.33898948
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.32691046
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32437041
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32422310
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.31356717
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31274572
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31007949
67* SPI1_23547873_ChIP-Seq_NB4_Human1.30021141
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29845622
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29112876
70SPI1_23127762_ChIP-Seq_K562_Human1.27981590
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25915965
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25619425
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25148656
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.24472930
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24419853
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24074556
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22417761
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22006725
79* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21512607
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21326493
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20451164
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17707446
83TP53_22127205_ChIP-Seq_IMR90_Human1.16344324
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15753015
85GATA1_19941826_ChIP-Seq_K562_Human1.14572211
86* MAF_26560356_Chip-Seq_TH2_Human1.14431187
87* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13141950
88* MYB_26560356_Chip-Seq_TH1_Human1.12284761
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11895107
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.11644919
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11562826
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10525067
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09906564
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09420786
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08779570
96* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07522423
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07155414
98SCL_19346495_ChIP-Seq_HPC-7_Human1.07030764
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06783114
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.06703053
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06539562
102CLOCK_20551151_ChIP-Seq_293T_Human1.06521352
103* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05383250
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05308705
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05148874
106CREB1_26743006_Chip-Seq_LNCaP_Human1.05059008
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04398650
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04070009
109* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03315276
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02952627
111TFEB_21752829_ChIP-Seq_HELA_Human1.02406115
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01923092
113PU_27001747_Chip-Seq_BMDM_Mouse1.01915769
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01850924
115RUNX_20019798_ChIP-Seq_JUKART_Human1.01710219
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00853167
117GATA6_25053715_ChIP-Seq_YYC3_Human1.00587672
118XRN2_22483619_ChIP-Seq_HELA_Human0.99347055
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99306507
120* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99168180
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98819347
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98319318
123* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97657700
124* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97196612
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97139106
126VDR_24787735_ChIP-Seq_THP-1_Human0.97059029
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.96768223
128SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96598845
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.96526007
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.95865737
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95572484
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95309156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.23488629
2MP0003705_abnormal_hypodermis_morpholog3.78145412
3MP0010352_gastrointestinal_tract_polyps2.98238242
4MP0005076_abnormal_cell_differentiation2.97417383
5MP0009278_abnormal_bone_marrow2.69700891
6MP0009840_abnormal_foam_cell2.60445582
7MP0002148_abnormal_hypersensitivity_rea2.59372104
8MP0009785_altered_susceptibility_to2.41594931
9MP0003300_gastrointestinal_ulcer2.40728155
10MP0003566_abnormal_cell_adhesion2.33001931
11MP0008438_abnormal_cutaneous_collagen2.27231118
12MP0005671_abnormal_response_to2.27187597
13MP0001835_abnormal_antigen_presentation2.27045172
14MP0005451_abnormal_body_composition2.21198822
15MP0004272_abnormal_basement_membrane2.08823758
16MP0006054_spinal_hemorrhage2.01095829
17MP0001545_abnormal_hematopoietic_system2.00110506
18MP0005397_hematopoietic_system_phenotyp2.00110506
19MP0003828_pulmonary_edema1.95583321
20MP0002254_reproductive_system_inflammat1.92202011
21MP0010307_abnormal_tumor_latency1.90859262
22MP0001853_heart_inflammation1.87300036
23MP0003436_decreased_susceptibility_to1.81451202
24MP0004510_myositis1.71845512
25MP0003172_abnormal_lysosome_physiology1.68911991
26MP0000490_abnormal_crypts_of1.67457049
27MP0004957_abnormal_blastocyst_morpholog1.62150516
28MP0010368_abnormal_lymphatic_system1.59804790
29MP0003091_abnormal_cell_migration1.58938415
30MP0003656_abnormal_erythrocyte_physiolo1.57443820
31MP0003763_abnormal_thymus_physiology1.56282576
32MP0004808_abnormal_hematopoietic_stem1.54626953
33MP0000685_abnormal_immune_system1.53648961
34MP0001845_abnormal_inflammatory_respons1.51818020
35MP0005623_abnormal_meninges_morphology1.49294687
36MP0003448_altered_tumor_morphology1.45534618
37MP0003279_aneurysm1.45487282
38MP0003111_abnormal_nucleus_morphology1.45369861
39MP0003191_abnormal_cellular_cholesterol1.45040850
40MP0010234_abnormal_vibrissa_follicle1.44820587
41MP0003693_abnormal_embryo_hatching1.43798712
42MP0009333_abnormal_splenocyte_physiolog1.43699272
43MP0005310_abnormal_salivary_gland1.40737318
44MP0005023_abnormal_wound_healing1.40494922
45MP0002086_abnormal_extraembryonic_tissu1.37165661
46MP0000350_abnormal_cell_proliferation1.34597743
47MP0002877_abnormal_melanocyte_morpholog1.31784077
48MP0004858_abnormal_nervous_system1.31734661
49MP0009764_decreased_sensitivity_to1.30083513
50MP0000858_altered_metastatic_potential1.29619880
51MP0005167_abnormal_blood-brain_barrier1.28869148
52MP0001730_embryonic_growth_arrest1.24739161
53MP0004185_abnormal_adipocyte_glucose1.24202225
54MP0001879_abnormal_lymphatic_vessel1.21473002
55MP0002405_respiratory_system_inflammati1.20977817
56MP0008961_abnormal_basal_metabolism1.20067790
57MP0010155_abnormal_intestine_physiology1.19294259
58MP0000767_abnormal_smooth_muscle1.19028106
59MP0006082_CNS_inflammation1.18250124
60MP0000733_abnormal_muscle_development1.16918313
61MP0002452_abnormal_antigen_presenting1.15904697
62MP0003453_abnormal_keratinocyte_physiol1.15459853
63MP0001915_intracranial_hemorrhage1.15262134
64MP0004947_skin_inflammation1.14455725
65MP0001873_stomach_inflammation1.14348499
66MP0002398_abnormal_bone_marrow1.13983495
67MP0003984_embryonic_growth_retardation1.11974014
68MP0005000_abnormal_immune_tolerance1.11193814
69MP0002088_abnormal_embryonic_growth/wei1.10982257
70MP0008469_abnormal_protein_level1.09866049
71MP0003077_abnormal_cell_cycle1.07598413
72MP0001697_abnormal_embryo_size1.06733135
73MP0000465_gastrointestinal_hemorrhage1.06255865
74MP0010030_abnormal_orbit_morphology1.06101693
75MP0005464_abnormal_platelet_physiology1.05948727
76MP0001672_abnormal_embryogenesis/_devel1.05264330
77MP0005380_embryogenesis_phenotype1.05264330
78MP0003866_abnormal_defecation1.05002926
79MP0002925_abnormal_cardiovascular_devel1.04557965
80MP0005257_abnormal_intraocular_pressure1.04130728
81MP0002396_abnormal_hematopoietic_system1.03805365
82MP0001849_ear_inflammation1.03250981
83MP0001800_abnormal_humoral_immune1.02356846
84MP0001533_abnormal_skeleton_physiology1.01661016
85MP0008260_abnormal_autophagy1.01656117
86MP0002138_abnormal_hepatobiliary_system1.01449566
87MP0002722_abnormal_immune_system1.00170066
88MP0005387_immune_system_phenotype0.99638813
89MP0001790_abnormal_immune_system0.99638813
90MP0000689_abnormal_spleen_morphology0.98759691
91MP0003075_altered_response_to0.97675400
92MP0004197_abnormal_fetal_growth/weight/0.97605506
93MP0001819_abnormal_immune_cell0.95947957
94MP0000604_amyloidosis0.95886279
95MP0004381_abnormal_hair_follicle0.95173413
96MP0002420_abnormal_adaptive_immunity0.95140392
97MP0001958_emphysema0.94134352
98MP0002080_prenatal_lethality0.93805695
99MP0005025_abnormal_response_to0.92933103
100MP0002084_abnormal_developmental_patter0.92090825
101MP0002019_abnormal_tumor_incidence0.91497511
102MP0002085_abnormal_embryonic_tissue0.90901893
103MP0003724_increased_susceptibility_to0.90135050
104MP0005666_abnormal_adipose_tissue0.89718881
105MP0002419_abnormal_innate_immunity0.89698368
106MP0002429_abnormal_blood_cell0.89383176
107MP0004782_abnormal_surfactant_physiolog0.87499022
108MP0000343_altered_response_to0.87306582
109MP0002796_impaired_skin_barrier0.87280525
110MP0003567_abnormal_fetal_cardiomyocyte0.85919233
111MP0002723_abnormal_immune_serum0.85851828
112MP0003045_fibrosis0.85227238
113MP0001348_abnormal_lacrimal_gland0.84044367
114MP0000477_abnormal_intestine_morphology0.83744990
115MP0002933_joint_inflammation0.83688076
116MP0005166_decreased_susceptibility_to0.83675186
117MP0000716_abnormal_immune_system0.82664608
118MP0000313_abnormal_cell_death0.82557776
119MP0010630_abnormal_cardiac_muscle0.81927188
120MP0005390_skeleton_phenotype0.81683655
121MP0000703_abnormal_thymus_morphology0.80960499
122MP0008004_abnormal_stomach_pH0.80528957
123MP0002998_abnormal_bone_remodeling0.80393895
124MP0001663_abnormal_digestive_system0.80145835
125MP0002139_abnormal_hepatobiliary_system0.80088000
126MP0005058_abnormal_lysosome_morphology0.79555341
127MP0003123_paternal_imprinting0.79475588
128MP0002089_abnormal_postnatal_growth/wei0.75862802
129MP0001851_eye_inflammation0.74595482
130MP0005375_adipose_tissue_phenotype0.73054238
131MP0000249_abnormal_blood_vessel0.72818989
132MP0002006_tumorigenesis0.72269948
133MP0003795_abnormal_bone_structure0.69677298
134MP0001542_abnormal_bone_strength0.65275779
135MP0005595_abnormal_vascular_smooth0.62839012
136MP0005164_abnormal_response_to0.62520311
137MP0004883_abnormal_blood_vessel0.61812364
138MP0005381_digestive/alimentary_phenotyp0.61631283

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.62809227
2Abnormality of liposaccharide metabolism (HP:0010968)4.45818765
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.45818765
4Abnormality of glycolipid metabolism (HP:0010969)4.45818765
5Protrusio acetabuli (HP:0003179)4.07348748
6Orchitis (HP:0100796)3.82652816
7Retrobulbar optic neuritis (HP:0100654)3.67255617
8Optic neuritis (HP:0100653)3.67255617
9Premature rupture of membranes (HP:0001788)3.63843230
10Nuclear cataract (HP:0100018)3.38797174
11Myositis (HP:0100614)3.37479333
12Cellulitis (HP:0100658)3.08623839
13Loss of speech (HP:0002371)3.04896617
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.04114481
15Genu recurvatum (HP:0002816)3.01642410
16Dysostosis multiplex (HP:0000943)2.94704469
17Systemic lupus erythematosus (HP:0002725)2.81577036
18Ulnar bowing (HP:0003031)2.81510447
19Shallow orbits (HP:0000586)2.65023651
20Keratoconjunctivitis sicca (HP:0001097)2.63421872
21Achilles tendon contracture (HP:0001771)2.58220073
22Mitral valve prolapse (HP:0001634)2.57894070
23Stomatitis (HP:0010280)2.54938788
24Ankle contracture (HP:0006466)2.53929096
25Hematochezia (HP:0002573)2.52455458
26Axonal loss (HP:0003447)2.47882345
27Dilatation of the ascending aorta (HP:0005111)2.46960398
28Increased density of long bones (HP:0006392)2.44677727
29Spontaneous hematomas (HP:0007420)2.41531222
30Recurrent viral infections (HP:0004429)2.41146149
31Hypercortisolism (HP:0001578)2.40266662
32Vacuolated lymphocytes (HP:0001922)2.39796542
33Polycythemia (HP:0001901)2.38925565
34Meningitis (HP:0001287)2.38074534
35Gastrointestinal stroma tumor (HP:0100723)2.33739436
36Annular pancreas (HP:0001734)2.32691974
37Vasculitis (HP:0002633)2.32342269
38Keratoconjunctivitis (HP:0001096)2.31342888
39Eczematoid dermatitis (HP:0000976)2.30718456
40Segmental peripheral demyelination/remyelination (HP:0003481)2.29283280
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27972480
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27972480
43Abnormality of polysaccharide metabolism (HP:0011012)2.27972480
44Rectal prolapse (HP:0002035)2.26906645
45Slow saccadic eye movements (HP:0000514)2.24361125
46Peritonitis (HP:0002586)2.22326499
47Pulmonary infiltrates (HP:0002113)2.19953138
48Recurrent abscess formation (HP:0002722)2.19419163
49Upper limb amyotrophy (HP:0009129)2.17644491
50Distal upper limb amyotrophy (HP:0007149)2.17644491
51Pustule (HP:0200039)2.15052515
52Increased connective tissue (HP:0009025)2.13680893
53Mucopolysacchariduria (HP:0008155)2.12375624
54Urinary glycosaminoglycan excretion (HP:0003541)2.12375624
55Disinhibition (HP:0000734)2.11869092
56Chronic obstructive pulmonary disease (HP:0006510)2.11837054
57Obstructive lung disease (HP:0006536)2.11837054
58Arterial thrombosis (HP:0004420)2.11003334
59Cervical subluxation (HP:0003308)2.10551060
60Tetraparesis (HP:0002273)2.10124500
61Reticulocytosis (HP:0001923)2.10011108
62Porencephaly (HP:0002132)2.09431592
63Fragile skin (HP:0001030)2.08968603
64Abnormality of the Achilles tendon (HP:0005109)2.08878807
65Hand muscle atrophy (HP:0009130)2.07402279
66Hemorrhage of the eye (HP:0011885)2.06519419
67Autoimmune thrombocytopenia (HP:0001973)2.05562555
68Aortic dissection (HP:0002647)2.04720268
69Aortic aneurysm (HP:0004942)2.04419120
70Vertebral compression fractures (HP:0002953)2.00731769
71Verrucae (HP:0200043)2.00589833
72Papilloma (HP:0012740)2.00589833
73Pathologic fracture (HP:0002756)1.99779622
74Recurrent skin infections (HP:0001581)1.99615699
75Increased serum ferritin (HP:0003281)1.99552884
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98836696
77Recurrent gram-negative bacterial infections (HP:0005420)1.98523363
78Increased IgE level (HP:0003212)1.98369988
79Elevated erythrocyte sedimentation rate (HP:0003565)1.97998192
80Trismus (HP:0000211)1.97100643
81Hemoptysis (HP:0002105)1.97080116
82Mildly elevated creatine phosphokinase (HP:0008180)1.97045748
83Apathy (HP:0000741)1.96352624
84Hyperacusis (HP:0010780)1.95188139
85Neuronal loss in central nervous system (HP:0002529)1.94027342
86Malnutrition (HP:0004395)1.94000781
87Recurrent fungal infections (HP:0002841)1.93869042
88Neurofibrillary tangles (HP:0002185)1.92051260
89Aneurysm (HP:0002617)1.90328602
90Basal cell carcinoma (HP:0002671)1.89172613
91Progressive neurologic deterioration (HP:0002344)1.89003903
92Atrophic scars (HP:0001075)1.87767962
93Premature loss of primary teeth (HP:0006323)1.85858977
94Emphysema (HP:0002097)1.84530781
95Diminished motivation (HP:0000745)1.83576852
96Bowed forearm bones (HP:0003956)1.83193580
97Bowing of the arm (HP:0006488)1.83193580
98Bone pain (HP:0002653)1.81527355
99Restrictive lung disease (HP:0002091)1.80612285
100Esophageal varix (HP:0002040)1.80226911
101Multiple enchondromatosis (HP:0005701)1.80141327
102Encephalitis (HP:0002383)1.79745678
103Colitis (HP:0002583)1.78406522
104J-shaped sella turcica (HP:0002680)1.77636152
105Interstitial pulmonary disease (HP:0006530)1.77084510
106Long palpebral fissure (HP:0000637)1.76861685
107Increased IgM level (HP:0003496)1.75927133
108Distal lower limb amyotrophy (HP:0008944)1.75000787
109Bulbar palsy (HP:0001283)1.74939218
110Radial bowing (HP:0002986)1.74929608
111Purpura (HP:0000979)1.74645668
112Increased cerebral lipofuscin (HP:0011813)1.74056399
113Cerebral inclusion bodies (HP:0100314)1.73881032
114High pitched voice (HP:0001620)1.73738470
115Abnormality of the nasal mucosa (HP:0000433)1.73054993
116Difficulty climbing stairs (HP:0003551)1.72911507
117Abnormality of reticulocytes (HP:0004312)1.72733650
118Abnormality of the distal phalanges of the toes (HP:0010182)1.71876924
119Multiple lipomas (HP:0001012)1.71011960
120Diaphragmatic weakness (HP:0009113)1.70998648
121Pulmonary embolism (HP:0002204)1.70542079
122Amyloidosis (HP:0011034)1.70042522
123Progressive sensorineural hearing impairment (HP:0000408)1.69864291
124Bicuspid aortic valve (HP:0001647)1.69642387
125Bladder diverticulum (HP:0000015)1.69439760
126Gingivitis (HP:0000230)1.68689193
127Abnormality of cells of the erythroid lineage (HP:0012130)1.68658020
128Hepatosplenomegaly (HP:0001433)1.68589225
129Ankyloglossia (HP:0010296)1.68390402
130Aseptic necrosis (HP:0010885)1.68185721
131Acrocyanosis (HP:0001063)1.68029409
132Abnormality of the peritoneum (HP:0002585)1.68016399
133Angiofibromas (HP:0010615)1.67464719
134Adenoma sebaceum (HP:0009720)1.67464719
135Blue sclerae (HP:0000592)1.67445685
136Glomerulonephritis (HP:0000099)1.67258857
137Lymphopenia (HP:0001888)1.67067281
138Mitral regurgitation (HP:0001653)1.65945409
139Polygenic inheritance (HP:0010982)1.65695017
140Abnormal hemoglobin (HP:0011902)1.65460288
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.65289644
142Osteolytic defects of the hand bones (HP:0009699)1.65289644
143Gastrointestinal infarctions (HP:0005244)1.63975654
144Hyperparathyroidism (HP:0000843)1.62181483
145Thoracic kyphosis (HP:0002942)1.61648480
146Thoracolumbar scoliosis (HP:0002944)1.61414122
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.61244899
148Abnormal vertebral ossification (HP:0100569)1.61199320
149Recurrent bacterial skin infections (HP:0005406)1.61162432
150Peripheral demyelination (HP:0011096)1.61157377
151Abnormality of macrophages (HP:0004311)1.60454015
152Subacute progressive viral hepatitis (HP:0006572)1.60377156
153Disproportionate tall stature (HP:0001519)1.60182555
154IgA deficiency (HP:0002720)1.59994699
155Abnormality of the acetabulum (HP:0003170)1.59695658
156Myocardial infarction (HP:0001658)1.59627842
157Enlarged penis (HP:0000040)1.59514119
158Renal duplication (HP:0000075)1.59245017
159Broad palm (HP:0001169)1.58416446
160Abnormal number of erythroid precursors (HP:0012131)1.58343816
161Hypochromic anemia (HP:0001931)1.56428943
162Mediastinal lymphadenopathy (HP:0100721)1.56410529
163Wrist flexion contracture (HP:0001239)1.56284043
164Gastrointestinal carcinoma (HP:0002672)1.55747720
165Malignant gastrointestinal tract tumors (HP:0006749)1.55747720
166Hyperextensible skin (HP:0000974)1.54865836
167Hallux valgus (HP:0001822)1.54331782
168Pointed chin (HP:0000307)1.54252540
169Vertebral hypoplasia (HP:0008417)1.53527663
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.53527663
171Deviation of the hallux (HP:0010051)1.53493799
172Fibroma (HP:0010614)1.53483131
173Camptodactyly of toe (HP:0001836)1.53256610
174Insomnia (HP:0100785)1.53238675
175Thin bony cortex (HP:0002753)1.52118000
176Bowel diverticulosis (HP:0005222)1.51709330
177Slender build (HP:0001533)1.50810146
178Abnormal platelet volume (HP:0011876)1.50345448
179Persistence of primary teeth (HP:0006335)1.49758823
180Spinal muscular atrophy (HP:0007269)1.49324797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.03883795
2MAP3K103.99570505
3TRIB33.97829583
4PRPF4B3.39019067
5PKN23.35185896
6EEF2K3.03261579
7ERN12.99344509
8RIPK12.45922476
9SMG12.44064373
10CDK122.38950252
11SIK12.36780543
12MAP3K142.24342521
13TAOK22.14474912
14IRAK41.86242233
15BMX1.84590026
16MAP4K11.82878068
17PIM21.81983082
18PDGFRA1.75191371
19SCYL21.72377070
20NME21.72115288
21NEK21.61866273
22STK101.60810826
23MAP3K111.59617449
24DDR21.57192510
25LRRK21.56634915
26IRAK21.52625737
27TLK11.47674416
28ALK1.46613644
29PAK41.42128084
30MAP3K131.41217731
31SIK31.39395639
32TAOK11.36951795
33RIPK41.36635610
34PTK61.36337335
35MATK1.36025764
36GRK61.34799721
37ICK1.32187302
38TBK11.25394703
39CSK1.25336850
40KSR21.21872284
41MAP3K81.17406610
42MOS1.15704960
43FGFR41.14892940
44IKBKE1.13045895
45CHUK1.11708559
46RPS6KA41.11023321
47CDC42BPA1.07999779
48TGFBR21.05682462
49PIM11.05357196
50IRAK11.05019811
51SIK21.04605306
52CDK61.03670402
53PRKG21.00659635
54EPHA21.00394794
55DMPK1.00344109
56STK240.99194002
57KDR0.96936272
58FGR0.96220872
59TTN0.95133330
60RPS6KB20.91828490
61LATS20.91570900
62MAP2K30.91532736
63TYRO30.90261951
64PDPK10.88913175
65STK40.88019682
66GRK70.85139612
67DAPK30.83888878
68BLK0.82042028
69CDK70.81711137
70ARAF0.81502843
71PTK20.79857074
72CDK40.79301544
73RET0.77957272
74FES0.77456955
75FLT30.77258774
76MAP2K20.75582353
77TIE10.72473625
78MTOR0.70876475
79DYRK1B0.70609643
80EPHB10.70274032
81TRPM70.69234093
82MAP3K90.68657675
83EPHB20.67706463
84PAK20.66685651
85STK30.66405640
86MAPKAPK30.64829802
87PTK2B0.60920194
88ZAP700.60516644
89WEE10.60041921
90MARK30.59819069
91RPS6KC10.59492445
92RPS6KL10.59492445
93HCK0.59439316
94CDC70.58083479
95TESK10.58031758
96TESK20.58021313
97NTRK10.57092284
98TYK20.56575319
99RPS6KA60.56326462
100MAPK110.55817647
101RPS6KA10.52827881
102PAK10.50953752
103BTK0.50574052
104BRAF0.49001765
105GRK50.48618853
106ILK0.48544620
107MAPK40.47938259
108EGFR0.47538908
109IKBKB0.47162496
110JAK10.45890946
111PDGFRB0.45878846
112TAF10.45427730
113MAPKAPK20.45396658
114RPS6KA20.45239189
115MAP2K60.44906152
116DAPK20.44634376
117CAMKK10.44474188
118HIPK20.44418377
119MAP3K30.44278649
120CDK90.44221443
121JAK20.43328845
122NEK90.42124620
123NEK10.41414242
124MARK20.41178714
125LYN0.41133533
126PDK10.40288629
127MAP2K10.40258304
128PRKD20.40026389
129CLK10.39642179
130BMPR20.38931284
131MAP3K10.38707615
132LCK0.38195857
133JAK30.37698102
134CSF1R0.36215720
135MAPK70.36046639
136YES10.35561385
137ABL20.32887696
138PRKCI0.31172384
139ITK0.30827780

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.14625938
2Chronic myeloid leukemia_Homo sapiens_hsa052201.94199204
3Allograft rejection_Homo sapiens_hsa053301.92542733
4Graft-versus-host disease_Homo sapiens_hsa053321.86188315
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83726554
6Rheumatoid arthritis_Homo sapiens_hsa053231.76875219
7Bladder cancer_Homo sapiens_hsa052191.74938584
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.70294560
9Leishmaniasis_Homo sapiens_hsa051401.69844476
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64837700
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60386921
12Small cell lung cancer_Homo sapiens_hsa052221.57173315
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52678504
14Lysosome_Homo sapiens_hsa041421.50343544
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49947920
16B cell receptor signaling pathway_Homo sapiens_hsa046621.48777391
17Osteoclast differentiation_Homo sapiens_hsa043801.45199799
18Staphylococcus aureus infection_Homo sapiens_hsa051501.44728340
19T cell receptor signaling pathway_Homo sapiens_hsa046601.44235146
20Shigellosis_Homo sapiens_hsa051311.43273240
21Autoimmune thyroid disease_Homo sapiens_hsa053201.42906778
22VEGF signaling pathway_Homo sapiens_hsa043701.42818787
23Asthma_Homo sapiens_hsa053101.39873928
24Ribosome_Homo sapiens_hsa030101.37481468
25Prion diseases_Homo sapiens_hsa050201.32415786
26Apoptosis_Homo sapiens_hsa042101.31292787
27Proteoglycans in cancer_Homo sapiens_hsa052051.29655138
28Toxoplasmosis_Homo sapiens_hsa051451.29499663
29Amoebiasis_Homo sapiens_hsa051461.27814582
30Type I diabetes mellitus_Homo sapiens_hsa049401.26198641
31Acute myeloid leukemia_Homo sapiens_hsa052211.24241611
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23607175
33Focal adhesion_Homo sapiens_hsa045101.23574738
34Glioma_Homo sapiens_hsa052141.22136772
35Tuberculosis_Homo sapiens_hsa051521.20814511
36Thyroid cancer_Homo sapiens_hsa052161.20168810
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.18849529
38Non-small cell lung cancer_Homo sapiens_hsa052231.18593269
39mTOR signaling pathway_Homo sapiens_hsa041501.18286458
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18250748
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.17731223
42Hepatitis B_Homo sapiens_hsa051611.17429806
43MicroRNAs in cancer_Homo sapiens_hsa052061.17251792
44Salmonella infection_Homo sapiens_hsa051321.17173753
45Viral carcinogenesis_Homo sapiens_hsa052031.15067096
46DNA replication_Homo sapiens_hsa030301.15030664
47Adherens junction_Homo sapiens_hsa045201.14938566
48Legionellosis_Homo sapiens_hsa051341.14810902
49HIF-1 signaling pathway_Homo sapiens_hsa040661.13469405
50Pancreatic cancer_Homo sapiens_hsa052121.11979220
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10897832
52African trypanosomiasis_Homo sapiens_hsa051431.10209035
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09588516
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09309874
55Platelet activation_Homo sapiens_hsa046111.08733305
56ECM-receptor interaction_Homo sapiens_hsa045121.08474969
57TNF signaling pathway_Homo sapiens_hsa046681.08072537
58Primary immunodeficiency_Homo sapiens_hsa053401.05823064
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04032374
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00132817
61Pertussis_Homo sapiens_hsa051330.99118074
62Cell cycle_Homo sapiens_hsa041100.98575367
63Malaria_Homo sapiens_hsa051440.98444057
64Notch signaling pathway_Homo sapiens_hsa043300.97822676
65HTLV-I infection_Homo sapiens_hsa051660.95921485
66p53 signaling pathway_Homo sapiens_hsa041150.95419182
67Colorectal cancer_Homo sapiens_hsa052100.94294518
68Hematopoietic cell lineage_Homo sapiens_hsa046400.94106917
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93579103
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.91911954
71Viral myocarditis_Homo sapiens_hsa054160.91837209
72Dorso-ventral axis formation_Homo sapiens_hsa043200.91785197
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90010416
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.89122184
75Influenza A_Homo sapiens_hsa051640.88697529
76Herpes simplex infection_Homo sapiens_hsa051680.86722564
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86683861
78Systemic lupus erythematosus_Homo sapiens_hsa053220.86434918
79Endometrial cancer_Homo sapiens_hsa052130.86095003
80Renal cell carcinoma_Homo sapiens_hsa052110.82895853
81Chemokine signaling pathway_Homo sapiens_hsa040620.82498389
82Hippo signaling pathway_Homo sapiens_hsa043900.82319032
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.82095104
84Endocytosis_Homo sapiens_hsa041440.82024089
85Base excision repair_Homo sapiens_hsa034100.81442055
86Prolactin signaling pathway_Homo sapiens_hsa049170.81199471
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80813740
88Estrogen signaling pathway_Homo sapiens_hsa049150.79941638
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79116501
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78906260
91Antigen processing and presentation_Homo sapiens_hsa046120.78560373
92Phagosome_Homo sapiens_hsa041450.78532304
93Sulfur relay system_Homo sapiens_hsa041220.78169773
94Pathways in cancer_Homo sapiens_hsa052000.77748705
95Measles_Homo sapiens_hsa051620.76066800
96Protein digestion and absorption_Homo sapiens_hsa049740.75861662
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75813718
98TGF-beta signaling pathway_Homo sapiens_hsa043500.75543380
99Rap1 signaling pathway_Homo sapiens_hsa040150.74445449
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73473734
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73147745
102Prostate cancer_Homo sapiens_hsa052150.72509896
103Alcoholism_Homo sapiens_hsa050340.70934677
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70509395
105Renin-angiotensin system_Homo sapiens_hsa046140.68420335
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67747739
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.67546952
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66552284
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.65779767
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65545263
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63539587
112Insulin resistance_Homo sapiens_hsa049310.63415509
113RNA transport_Homo sapiens_hsa030130.62904233
114ErbB signaling pathway_Homo sapiens_hsa040120.62554169
115Mismatch repair_Homo sapiens_hsa034300.61448348
116Melanoma_Homo sapiens_hsa052180.60824928
117Gap junction_Homo sapiens_hsa045400.60285281
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.59520936
119Oocyte meiosis_Homo sapiens_hsa041140.59133702
120Epstein-Barr virus infection_Homo sapiens_hsa051690.59125299
121Hepatitis C_Homo sapiens_hsa051600.58941556
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.58338004
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58057912
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56727906
125Type II diabetes mellitus_Homo sapiens_hsa049300.50506654
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50132584
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47101197
128Vibrio cholerae infection_Homo sapiens_hsa051100.46518945
129Insulin signaling pathway_Homo sapiens_hsa049100.46418272
130FoxO signaling pathway_Homo sapiens_hsa040680.46248223
131MAPK signaling pathway_Homo sapiens_hsa040100.43767305
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43334527

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