MESP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular anion homeostasis (GO:0030002)9.92820136
2sperm motility (GO:0030317)9.66947971
3sperm-egg recognition (GO:0035036)9.54212225
4cilium or flagellum-dependent cell motility (GO:0001539)9.35102288
5binding of sperm to zona pellucida (GO:0007339)8.79211441
6acrosome assembly (GO:0001675)8.66910917
7positive regulation of endothelial cell apoptotic process (GO:2000353)8.66905136
8cell-cell recognition (GO:0009988)8.52132491
9acrosome reaction (GO:0007340)8.46074533
10multicellular organism reproduction (GO:0032504)8.37607117
11positive regulation of fibroblast migration (GO:0010763)8.33501407
12plasma membrane fusion (GO:0045026)8.01133876
13axonemal dynein complex assembly (GO:0070286)7.70340630
14motile cilium assembly (GO:0044458)7.45702851
15spermatid development (GO:0007286)7.35161135
16reproduction (GO:0000003)7.13932584
17epithelial cilium movement (GO:0003351)6.97997162
18DNA deamination (GO:0045006)6.48900712
19T cell apoptotic process (GO:0070231)6.45216808
20piRNA metabolic process (GO:0034587)6.34977120
21growth hormone receptor signaling pathway (GO:0060396)6.30106511
22male meiosis (GO:0007140)6.28485349
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.22250152
24necroptotic process (GO:0070266)5.93306791
25synaptonemal complex organization (GO:0070193)5.93212267
26synaptonemal complex assembly (GO:0007130)5.87561458
27regulation of cilium movement (GO:0003352)5.86444537
28cilium movement (GO:0003341)5.82210167
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.81493072
30single strand break repair (GO:0000012)5.71628979
31left/right pattern formation (GO:0060972)5.65105493
32lymphocyte apoptotic process (GO:0070227)5.57424184
33otic vesicle formation (GO:0030916)5.51564109
34cellular response to growth hormone stimulus (GO:0071378)5.51400021
35positive regulation of lamellipodium organization (GO:1902745)5.50146738
36respiratory system process (GO:0003016)5.41568189
37sleep (GO:0030431)5.40998770
38single fertilization (GO:0007338)5.37870636
39proline biosynthetic process (GO:0006561)5.03125880
40* cell migration involved in gastrulation (GO:0042074)4.99305266
41positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)4.96903513
42negative regulation of inclusion body assembly (GO:0090084)4.94043183
43positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)4.92781200
44microtubule depolymerization (GO:0007019)4.91863814
45sperm capacitation (GO:0048240)4.89998167
46spermatogenesis (GO:0007283)4.82031945
47male gamete generation (GO:0048232)4.81245013
48fat-soluble vitamin catabolic process (GO:0042363)4.80656197
49vitamin catabolic process (GO:0009111)4.80656197
50primitive streak formation (GO:0090009)4.71956190
51positive regulation of extracellular matrix organization (GO:1903055)4.68516924
52fertilization (GO:0009566)4.61468943
53positive regulation of ERBB signaling pathway (GO:1901186)4.58230652
54positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.46022944
55negative regulation of telomerase activity (GO:0051974)4.44597117
56gamete generation (GO:0007276)4.44115123
57chaperone-mediated protein complex assembly (GO:0051131)4.41572134
58chromosome condensation (GO:0030261)4.37751604
59intracellular pH reduction (GO:0051452)4.37634820
60DNA replication checkpoint (GO:0000076)4.37289412
61somite rostral/caudal axis specification (GO:0032525)4.31583331
62regulation of inclusion body assembly (GO:0090083)4.31556418
63insulin-like growth factor receptor signaling pathway (GO:0048009)4.26807358
64organic cation transport (GO:0015695)4.26531870
65biotin metabolic process (GO:0006768)4.20404635
66positive regulation of establishment of protein localization to plasma membrane (GO:0090004)4.19087388
67* signal transduction involved in regulation of gene expression (GO:0023019)4.19050651
68male meiosis I (GO:0007141)4.16740247
69extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)4.16719758
70DNA packaging (GO:0006323)4.15258041
71regulation of metalloenzyme activity (GO:0048552)4.13151677
72germ cell development (GO:0007281)4.10994890
73chromosome organization involved in meiosis (GO:0070192)4.10700263
74spermatid nucleus differentiation (GO:0007289)4.04026453
75cellular process involved in reproduction in multicellular organism (GO:0022412)4.03699368
76leukocyte apoptotic process (GO:0071887)4.01089790
77positive regulation of protein localization to plasma membrane (GO:1903078)4.00173027
78meiotic nuclear division (GO:0007126)3.99122776
79cytidine deamination (GO:0009972)3.98657606
80cytidine metabolic process (GO:0046087)3.98657606
81cytidine catabolic process (GO:0006216)3.98657606
82* regulation of mesoderm development (GO:2000380)3.97036969
83pH reduction (GO:0045851)3.96798099
84regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.96356907
85regulation of substrate adhesion-dependent cell spreading (GO:1900024)3.95711295
86DNA methylation involved in gamete generation (GO:0043046)3.91148886
87ventricular system development (GO:0021591)3.90530369
88cell recognition (GO:0008037)3.90502192
89hydrogen peroxide biosynthetic process (GO:0050665)3.87869664
90programmed necrotic cell death (GO:0097300)3.85329983
91calcium ion-dependent exocytosis (GO:0017156)3.80808761
92low-density lipoprotein particle clearance (GO:0034383)3.78550909
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.75279460
94reactive oxygen species biosynthetic process (GO:1903409)3.75069057
95Golgi transport vesicle coating (GO:0048200)3.73697385
96COPI coating of Golgi vesicle (GO:0048205)3.73697385
97microtubule severing (GO:0051013)3.70261225
98positive regulation of protein targeting to membrane (GO:0090314)3.70211432
99regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.60912523
100positive regulation of interleukin-17 production (GO:0032740)3.60445391
101seminiferous tubule development (GO:0072520)3.54267174
102meiosis I (GO:0007127)3.53975689
103negative regulation of DNA biosynthetic process (GO:2000279)3.52344242
104negative regulation of glycogen biosynthetic process (GO:0045719)3.52261754
105regulation of centriole replication (GO:0046599)3.48562139
106multicellular organismal reproductive process (GO:0048609)3.46383236
107necrotic cell death (GO:0070265)3.46200496
108anion homeostasis (GO:0055081)3.44745979
109regulation of telomerase activity (GO:0051972)3.40786790
110glycerol ether metabolic process (GO:0006662)3.39352415
111negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.38586607
112cell-substrate adherens junction assembly (GO:0007045)3.38302027
113focal adhesion assembly (GO:0048041)3.38302027
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37652786
115developmental programmed cell death (GO:0010623)3.37508753
116T-helper 1 type immune response (GO:0042088)3.36110830
117regulation of spindle checkpoint (GO:0090231)3.35449891
118protein complex localization (GO:0031503)3.32619144
119meiotic cell cycle (GO:0051321)3.32111933
120regulation of microtubule-based movement (GO:0060632)3.30425287
121regulation of sequestering of triglyceride (GO:0010889)3.29321517
122protein homotrimerization (GO:0070207)3.29105583
123pyrimidine ribonucleoside catabolic process (GO:0046133)3.26507499
124proline metabolic process (GO:0006560)3.22910047
125DNA replication-dependent nucleosome organization (GO:0034723)3.18220312
126DNA replication-dependent nucleosome assembly (GO:0006335)3.18220312
127regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.16713367
128positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.16713367
129response to growth hormone (GO:0060416)3.16321821
130anterior/posterior axis specification, embryo (GO:0008595)3.16267389
131epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.14955373
132* gastrulation (GO:0007369)3.12516316
133negative regulation of mRNA processing (GO:0050686)3.11581564
134ether metabolic process (GO:0018904)3.11321165
135valine metabolic process (GO:0006573)3.10134021
136positive regulation of gastrulation (GO:2000543)3.09602346
137regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.05405678
138positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.05405678
139regulation of protein targeting to membrane (GO:0090313)3.04240083
140genitalia morphogenesis (GO:0035112)3.02831571
141fatty acid homeostasis (GO:0055089)3.01940264
142mitotic sister chromatid cohesion (GO:0007064)3.00613678
143response to misfolded protein (GO:0051788)2.99224881
144triglyceride catabolic process (GO:0019433)2.98138675
145regulation of fibroblast migration (GO:0010762)2.97783665
146negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.96737716
147behavioral response to nicotine (GO:0035095)2.95763875
148cellular response to cadmium ion (GO:0071276)2.95751342
149negative regulation of glycogen metabolic process (GO:0070874)2.94325931
150deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93197364
151cell migration in hindbrain (GO:0021535)2.93057774
152nodal signaling pathway (GO:0038092)2.91681334
153brown fat cell differentiation (GO:0050873)2.91210162
154blastocyst development (GO:0001824)2.89514293
155gene silencing by RNA (GO:0031047)2.89020797
156multicellular organismal development (GO:0007275)2.87660508
157histone exchange (GO:0043486)2.86923467
158negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.84522905
159positive regulation of vesicle fusion (GO:0031340)2.82368007
160protein-DNA complex disassembly (GO:0032986)2.81982121
161nucleosome disassembly (GO:0006337)2.81982121
162nuclear pore complex assembly (GO:0051292)2.81648942
163heterochromatin organization (GO:0070828)2.81397459
164microtubule polymerization or depolymerization (GO:0031109)2.81186228
165sexual reproduction (GO:0019953)2.81071717
166oxaloacetate metabolic process (GO:0006107)2.81039851
167neutral lipid catabolic process (GO:0046461)2.80543337
168acylglycerol catabolic process (GO:0046464)2.80543337
169nucleus organization (GO:0006997)2.77794004
170retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77184495
171protein localization to chromosome, centromeric region (GO:0071459)2.76641781
172nuclear pore organization (GO:0006999)2.75234151
173postsynaptic membrane organization (GO:0001941)2.75084768
174purine deoxyribonucleotide catabolic process (GO:0009155)2.75001088
175viral mRNA export from host cell nucleus (GO:0046784)2.74775521
176glycolytic process (GO:0006096)2.74745843
177trophoblast giant cell differentiation (GO:0060707)2.74396040
178positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.73674109
179negative regulation of RNA splicing (GO:0033119)2.73327568
180fatty acid transmembrane transport (GO:1902001)2.72973479
181anterior/posterior axis specification (GO:0009948)2.72223443
182post-anal tail morphogenesis (GO:0036342)2.72208802
183centriole replication (GO:0007099)2.72080061
184carnitine shuttle (GO:0006853)2.71251249
185positive regulation of prostaglandin secretion (GO:0032308)2.68567094
186meiotic cell cycle process (GO:1903046)2.67272526
187centriole assembly (GO:0098534)2.66265247
188NADH metabolic process (GO:0006734)2.66041526
189negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.65517988
190phenol-containing compound catabolic process (GO:0019336)2.64730725
191regulation of lamellipodium organization (GO:1902743)2.63871411
192artery development (GO:0060840)2.62254930
193regulation of intracellular pH (GO:0051453)2.62057279
194cellular carbohydrate catabolic process (GO:0044275)2.59774427
195chaperone-mediated protein transport (GO:0072321)2.58044635
196negative regulation of multicellular organism growth (GO:0040015)2.57962702
197fusion of sperm to egg plasma membrane (GO:0007342)10.6898368
198cell wall macromolecule metabolic process (GO:0044036)10.4049339
199cell wall macromolecule catabolic process (GO:0016998)10.4049339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse7.22666830
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.24616729
3ZNF263_19887448_ChIP-Seq_K562_Human4.89047431
4E2F7_22180533_ChIP-Seq_HELA_Human3.37775911
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.32435433
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07024236
7* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.76778477
8EZH2_22144423_ChIP-Seq_EOC_Human2.74382731
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.71203018
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61881533
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58611299
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.55905056
13LXR_22292898_ChIP-Seq_THP-1_Human2.40597407
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35151600
15VDR_22108803_ChIP-Seq_LS180_Human2.03855387
16* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.01510850
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.3663047
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.99043360
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96161404
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96034777
21P68_20966046_ChIP-Seq_HELA_Human1.91173804
22RACK7_27058665_Chip-Seq_MCF-7_Human1.91112364
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90187306
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.89230739
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88186161
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88182817
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87812647
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84844227
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.81379080
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75628627
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67484429
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.67080635
33* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.66939600
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65926848
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65865402
36MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.65853452
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.65688135
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65093358
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63566351
40ZNF274_21170338_ChIP-Seq_K562_Hela1.61064247
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60385083
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60352303
43XRN2_22483619_ChIP-Seq_HELA_Human1.57832785
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56765119
45VDR_21846776_ChIP-Seq_THP-1_Human1.56274818
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56072919
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55735594
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55041726
49SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.54750269
50KDM5A_27292631_Chip-Seq_BREAST_Human1.54613825
51STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.53888902
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52727544
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.51185856
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50870773
55* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50866840
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50497283
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.49788829
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.49259807
59CTCF_27219007_Chip-Seq_Bcells_Human1.47470898
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.46520671
61SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.46361095
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44973959
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42618540
64FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39784224
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.38029652
66* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36473760
67* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36473760
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35475875
69* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35010699
70* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33205570
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.32183607
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.31582374
73CREB1_26743006_Chip-Seq_LNCaP_Human1.30751211
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.30629974
75SA1_27219007_Chip-Seq_Bcells_Human1.30416781
76GATA3_21867929_ChIP-Seq_CD8_Mouse1.30213433
77AR_21909140_ChIP-Seq_LNCAP_Human1.30162910
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29300948
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.27849785
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27527106
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.27061786
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26112622
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25757174
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25258180
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24020576
86* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23794792
87ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23282447
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22896806
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22264594
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22101721
91* E2F1_20622854_ChIP-Seq_HELA_Human1.20570284
92STAT1_17558387_ChIP-Seq_HELA_Human1.20480944
93* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19965185
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18301145
95KDM2B_26808549_Chip-Seq_K562_Human1.17833416
96ERA_21632823_ChIP-Seq_H3396_Human1.17807475
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17065804
98SMC4_20622854_ChIP-Seq_HELA_Human1.16668616
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16571039
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16063598
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.14615808
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13937508
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.13382471
104WDR5_24793694_ChIP-Seq_LNCAP_Human1.13150508
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12850324
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12811356
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12663656
108* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12557380
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12357339
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12282734
111LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11921341
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11629139
113TTF2_22483619_ChIP-Seq_HELA_Human1.11326738
114TP63_22573176_ChIP-Seq_HFKS_Human1.11292877
115* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11275198
116BCL6_27268052_Chip-Seq_Bcells_Human1.11183761
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.10907064
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10756055
119TET1_21490601_ChIP-Seq_MESCs_Mouse1.10726045
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10255807
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09914731
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09913974
123TAF2_19829295_ChIP-Seq_ESCs_Human1.09148150
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08797430
125KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08375012
126GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.08361140
127RXR_22158963_ChIP-Seq_LIVER_Mouse1.08271054
128PHF8_20622854_ChIP-Seq_HELA_Human1.08015643
129CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06798801
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06710370
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05152425
132* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03097242
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.02006603
134FLI1_27457419_Chip-Seq_LIVER_Mouse1.01120392
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01103062
136SPI1_26923725_Chip-Seq_HPCs_Mouse1.00968689
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00393189
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00323475
139TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98297190
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97678240
141BCOR_27268052_Chip-Seq_Bcells_Human0.97587416
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97389840
143* P53_21459846_ChIP-Seq_SAOS-2_Human0.96927185
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95478794
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95301282
146KDM2B_26808549_Chip-Seq_DND41_Human0.95081381
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94941258
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.94681050
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.94266203
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92957374
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92957374
152* CTCF_20526341_ChIP-Seq_ESCs_Human0.92036032
153RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91787926
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.90981258
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89213444
156GABP_17652178_ChIP-ChIP_JURKAT_Human0.88433868
157* FOXP1_21924763_ChIP-Seq_HESCs_Human0.88173586
158SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87787586
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.87252655
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84414545
161CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84369460
162CTCF_26484167_Chip-Seq_Bcells_Mouse0.83488115
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82636281
164GABP_19822575_ChIP-Seq_HepG2_Human0.82333285
165RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81855091
166NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81810734
167EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81220311
168EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80726453
169MYC_18940864_ChIP-ChIP_HL60_Human0.80697937
170NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80547128
171RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79068820
172RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78716749
173EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78403697
174POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78328026
175MYC_19829295_ChIP-Seq_ESCs_Human0.78095062
176HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.77688757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005666_abnormal_adipose_tissue5.53081076
2MP0003890_abnormal_embryonic-extraembry5.38626994
3MP0001873_stomach_inflammation5.15907738
4MP0004130_abnormal_muscle_cell4.69632827
5MP0008877_abnormal_DNA_methylation4.27912488
6MP0002653_abnormal_ependyma_morphology4.13743034
7MP0003698_abnormal_male_reproductive4.13296460
8MP0001929_abnormal_gametogenesis3.93539498
9MP0004510_myositis3.76362232
10MP0005375_adipose_tissue_phenotype3.58325707
11MP0004185_abnormal_adipocyte_glucose3.44563540
12MP0002102_abnormal_ear_morphology3.24202971
13MP0004133_heterotaxia3.14167933
14MP0003119_abnormal_digestive_system2.79219669
15MP0003283_abnormal_digestive_organ2.76820237
16MP0002210_abnormal_sex_determination2.73309158
17MP0004145_abnormal_muscle_electrophysio2.57164066
18MP0003123_paternal_imprinting2.52456354
19MP0005334_abnormal_fat_pad2.34850006
20MP0001145_abnormal_male_reproductive2.32955436
21MP0005360_urolithiasis2.31937047
22MP0004957_abnormal_blastocyst_morpholog2.29982492
23MP0002161_abnormal_fertility/fecundity2.29092484
24MP0002160_abnormal_reproductive_system2.18232924
25MP0005670_abnormal_white_adipose2.10170312
26MP0003879_abnormal_hair_cell2.05760254
27MP0005410_abnormal_fertilization11.0864711
28MP0000653_abnormal_sex_gland1.96554238
29MP0002971_abnormal_brown_adipose1.91265789
30MP0010094_abnormal_chromosome_stability1.90729643
31MP0000465_gastrointestinal_hemorrhage1.89099759
32MP0002735_abnormal_chemical_nociception1.79395304
33MP0003693_abnormal_embryo_hatching1.78926330
34MP0005448_abnormal_energy_balance1.75979723
35MP0003077_abnormal_cell_cycle1.75028116
36* MP0002084_abnormal_developmental_patter1.73679832
37* MP0002234_abnormal_pharynx_morphology1.71998891
38MP0002822_catalepsy1.71089888
39* MP0008932_abnormal_embryonic_tissue1.68279227
40* MP0001730_embryonic_growth_arrest1.64375972
41MP0006276_abnormal_autonomic_nervous1.62344155
42MP0009115_abnormal_fat_cell1.61664456
43MP0005451_abnormal_body_composition1.59755368
44MP0002970_abnormal_white_adipose1.52221201
45MP0008057_abnormal_DNA_replication1.52106323
46MP0005423_abnormal_somatic_nervous1.51419545
47MP0005535_abnormal_body_temperature1.50834196
48MP0004233_abnormal_muscle_weight1.49790492
49MP0005645_abnormal_hypothalamus_physiol1.49302842
50MP0000678_abnormal_parathyroid_gland1.49042995
51* MP0001672_abnormal_embryogenesis/_devel1.48082754
52* MP0005380_embryogenesis_phenotype1.48082754
53MP0003111_abnormal_nucleus_morphology1.47219825
54MP0004858_abnormal_nervous_system1.47218918
55MP0003937_abnormal_limbs/digits/tail_de1.45069229
56MP0008058_abnormal_DNA_repair1.44548636
57MP0000003_abnormal_adipose_tissue1.41580737
58MP0003075_altered_response_to1.40685006
59MP0004782_abnormal_surfactant_physiolog1.39439201
60MP0005647_abnormal_sex_gland1.39119370
61MP0001881_abnormal_mammary_gland1.37996679
62MP0003959_abnormal_lean_body1.32617422
63* MP0002085_abnormal_embryonic_tissue1.28015796
64MP0001664_abnormal_digestion1.27825211
65MP0000462_abnormal_digestive_system1.26982282
66MP0010030_abnormal_orbit_morphology1.26734497
67MP0002111_abnormal_tail_morphology1.26301892
68MP0003942_abnormal_urinary_system1.25644194
69MP0005452_abnormal_adipose_tissue1.24678940
70* MP0001697_abnormal_embryo_size1.23517833
71MP0006036_abnormal_mitochondrial_physio1.23086015
72MP0002118_abnormal_lipid_homeostasis1.21990225
73MP0004859_abnormal_synaptic_plasticity1.21047291
74MP0001968_abnormal_touch/_nociception1.20210747
75MP0002078_abnormal_glucose_homeostasis1.18424957
76MP0002736_abnormal_nociception_after1.18109143
77MP0000537_abnormal_urethra_morphology1.17611792
78* MP0003984_embryonic_growth_retardation1.16020990
79MP0003635_abnormal_synaptic_transmissio1.14889377
80MP0001944_abnormal_pancreas_morphology1.14332711
81* MP0002088_abnormal_embryonic_growth/wei1.14312496
82MP0000750_abnormal_muscle_regeneration1.12737069
83MP0008875_abnormal_xenobiotic_pharmacok1.12453302
84MP0002876_abnormal_thyroid_physiology1.11476111
85MP0000631_abnormal_neuroendocrine_gland1.11414088
86MP0003011_delayed_dark_adaptation1.11144792
87MP0001293_anophthalmia1.10834271
88MP0003385_abnormal_body_wall1.09588008
89MP0000759_abnormal_skeletal_muscle1.09266797
90MP0002693_abnormal_pancreas_physiology1.08996248
91MP0002163_abnormal_gland_morphology1.08969853
92MP0000534_abnormal_ureter_morphology1.08456768
93MP0009384_cardiac_valve_regurgitation1.07566395
94MP0000049_abnormal_middle_ear1.06202156
95MP0005389_reproductive_system_phenotype1.03758369
96MP0008872_abnormal_physiological_respon1.03083914
97MP0002733_abnormal_thermal_nociception1.01922347
98MP0008007_abnormal_cellular_replicative1.01720245
99MP0000627_abnormal_mammary_gland1.00408464
100MP0009046_muscle_twitch0.99653204
101MP0003953_abnormal_hormone_level0.99548836
102MP0002909_abnormal_adrenal_gland0.97549680
103MP0006072_abnormal_retinal_apoptosis0.95675328
104MP0005623_abnormal_meninges_morphology0.95634007
105MP0001905_abnormal_dopamine_level0.95593529
106MP0005379_endocrine/exocrine_gland_phen0.95344939
107* MP0003861_abnormal_nervous_system0.94788532
108MP0000751_myopathy0.94720185
109MP0001970_abnormal_pain_threshold0.94253829
110* MP0002080_prenatal_lethality0.92930241
111* MP0004087_abnormal_muscle_fiber0.92134376
112MP0004742_abnormal_vestibular_system0.90155441
113MP0002086_abnormal_extraembryonic_tissu0.89990648
114MP0001346_abnormal_lacrimal_gland0.89441886
115MP0004197_abnormal_fetal_growth/weight/0.89242968
116MP0010386_abnormal_urinary_bladder0.88462878
117MP0003948_abnormal_gas_homeostasis0.87478922
118MP0000013_abnormal_adipose_tissue0.86511898
119MP0001663_abnormal_digestive_system0.85787295
120MP0001485_abnormal_pinna_reflex0.85663104
121MP0000358_abnormal_cell_content/0.84542152
122MP0001440_abnormal_grooming_behavior0.83369375
123* MP0000432_abnormal_head_morphology0.82895587
124MP0003186_abnormal_redox_activity0.81930026
125MP0002272_abnormal_nervous_system0.81852126
126MP0004924_abnormal_behavior0.80835235
127MP0005386_behavior/neurological_phenoty0.80835235
128MP0002734_abnormal_mechanical_nocicepti0.79037012
129MP0003880_abnormal_central_pattern0.78771981
130MP0000350_abnormal_cell_proliferation0.78708012
131MP0003315_abnormal_perineum_morphology0.77904795
132MP0002638_abnormal_pupillary_reflex0.76533234
133MP0000613_abnormal_salivary_gland0.76340021
134* MP0003935_abnormal_craniofacial_develop0.76254556
135MP0005166_decreased_susceptibility_to0.75874349
136MP0003115_abnormal_respiratory_system0.73568298
137MP0000428_abnormal_craniofacial_morphol0.72687226
138MP0010329_abnormal_lipoprotein_level0.72090971
139MP0003936_abnormal_reproductive_system0.71406859
140MP0005646_abnormal_pituitary_gland0.71230668
141MP0000343_altered_response_to0.70745189
142MP0008775_abnormal_heart_ventricle0.70323237
143MP0002127_abnormal_cardiovascular_syste0.69107229
144MP0001529_abnormal_vocalization0.68900938
145MP0002282_abnormal_trachea_morphology0.68871602
146MP0003121_genomic_imprinting0.67799762
147MP0004270_analgesia0.67711942
148MP0002938_white_spotting0.67589700
149MP0002106_abnormal_muscle_physiology0.66260730
150MP0009745_abnormal_behavioral_response0.63732437
151MP0002069_abnormal_eating/drinking_beha0.63050955
152* MP0002932_abnormal_joint_morphology0.62845936
153MP0002089_abnormal_postnatal_growth/wei0.62739501
154MP0000313_abnormal_cell_death0.62171032
155MP0005332_abnormal_amino_acid0.61980362
156MP0005369_muscle_phenotype0.61787210
157MP0005381_digestive/alimentary_phenotyp0.61231311
158MP0001727_abnormal_embryo_implantation0.61186055
159MP0005499_abnormal_olfactory_system0.60793902
160MP0005394_taste/olfaction_phenotype0.60793902
161* MP0002925_abnormal_cardiovascular_devel0.59076435
162MP0010352_gastrointestinal_tract_polyps0.56070200
163MP0009053_abnormal_anal_canal0.54823975
164MP0009672_abnormal_birth_weight0.54725766
165MP0003806_abnormal_nucleotide_metabolis0.54403730
166MP0002269_muscular_atrophy0.53664590
167MP0001984_abnormal_olfaction0.53240839
168MP0008789_abnormal_olfactory_epithelium0.53089119
169MP0003632_abnormal_nervous_system0.51504508
170MP0002254_reproductive_system_inflammat0.50206685
171MP0000538_abnormal_urinary_bladder0.49694887
172MP0003938_abnormal_ear_development0.49317147
173MP0005391_vision/eye_phenotype0.48960870
174MP0002116_abnormal_craniofacial_bone0.47390402
175MP0005253_abnormal_eye_physiology0.45583939
176MP0002697_abnormal_eye_size0.44028037
177MP0002332_abnormal_exercise_endurance0.42998166
178MP0003646_muscle_fatigue0.42241103
179* MP0002114_abnormal_axial_skeleton0.41944990
180MP0002092_abnormal_eye_morphology0.40000151
181MP0001849_ear_inflammation0.39931866
182MP0002233_abnormal_nose_morphology0.39549876
183* MP0000266_abnormal_heart_morphology0.39493443
184MP0002152_abnormal_brain_morphology0.38994286
185MP0003786_premature_aging0.35497929
186MP0006035_abnormal_mitochondrial_morpho0.34926571
187MP0003566_abnormal_cell_adhesion0.32381052
188MP0001119_abnormal_female_reproductive0.32282573
189MP0002249_abnormal_larynx_morphology0.31878766

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)9.93994984
2Abnormal respiratory epithelium morphology (HP:0012253)7.99023374
3Abnormal respiratory motile cilium morphology (HP:0005938)7.99023374
4Abnormal respiratory motile cilium physiology (HP:0012261)7.95478470
5Birth length less than 3rd percentile (HP:0003561)7.93444677
6Increased IgM level (HP:0003496)7.69964343
7Autoimmune hemolytic anemia (HP:0001890)7.63430388
8Chronic bronchitis (HP:0004469)7.31240742
9Neonatal hypoglycemia (HP:0001998)6.99962031
10Rhinitis (HP:0012384)6.72172978
11Decreased activity of mitochondrial respiratory chain (HP:0008972)6.36421442
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)6.36421442
13Lip pit (HP:0100267)6.27067112
14Abnormal ciliary motility (HP:0012262)6.15561847
15Abnormal delayed hypersensitivity skin test (HP:0002963)5.96091386
16Sparse lateral eyebrow (HP:0005338)5.79030930
17Insulin-resistant diabetes mellitus (HP:0000831)5.54066305
18Infertility (HP:0000789)5.50294850
19Chin dimple (HP:0010751)5.35045482
20Myotonia (HP:0002486)5.24064436
21Anterior segment dysgenesis (HP:0007700)5.13668828
22Nasal polyposis (HP:0100582)5.09634951
23Premature skin wrinkling (HP:0100678)4.85487056
24Glucose intolerance (HP:0000833)4.73210655
25Enlarged epiphyses (HP:0010580)4.70117164
26Hypochromic anemia (HP:0001931)4.53899995
27Epileptic encephalopathy (HP:0200134)4.10796898
28Abnormality of the fingertips (HP:0001211)4.10157333
29Abnormality of the nasal mucosa (HP:0000433)4.09216311
30Eosinophilia (HP:0001880)4.06926284
31Depressed nasal tip (HP:0000437)3.97820817
32Bronchiectasis (HP:0002110)3.94394853
33Bronchitis (HP:0012387)3.94168174
34Abnormality of the columella (HP:0009929)3.91285515
35Hypoplasia of the iris (HP:0007676)3.74505243
36Rib fusion (HP:0000902)3.72138988
37Granulocytopenia (HP:0001913)3.47996729
38Insulin resistance (HP:0000855)3.44799136
39Nephronophthisis (HP:0000090)3.44064416
40Agammaglobulinemia (HP:0004432)3.41847309
41Hyperglycemia (HP:0003074)3.35614071
42Abnormal glucose tolerance (HP:0001952)3.15757716
43Supernumerary spleens (HP:0009799)3.11695102
44Male infertility (HP:0003251)2.95662211
45Myokymia (HP:0002411)2.83048360
46Abnormality of T cell physiology (HP:0011840)2.82672985
47Abnormal spermatogenesis (HP:0008669)2.75896824
48Abnormal pancreas size (HP:0012094)2.73053082
49Long palpebral fissure (HP:0000637)2.69874101
50Abnormality of T cell number (HP:0011839)2.69348131
51Congenital malformation of the right heart (HP:0011723)2.67637799
52Double outlet right ventricle (HP:0001719)2.67637799
53Fatigable weakness (HP:0003473)2.66245380
54Abnormality of the neuromuscular junction (HP:0003398)2.66245380
55Impulsivity (HP:0100710)2.62752374
56Medial flaring of the eyebrow (HP:0010747)2.62665199
57Abnormality of eosinophils (HP:0001879)2.62478701
58Oligomenorrhea (HP:0000876)2.61139843
59Easy fatigability (HP:0003388)2.59211558
60Abnormality of abdominal situs (HP:0011620)2.58471780
61Abdominal situs inversus (HP:0003363)2.58471780
62Prominent supraorbital ridges (HP:0000336)2.57291528
63Recurrent otitis media (HP:0000403)2.56541934
64Abnormality of permanent molar morphology (HP:0011071)2.55933569
65Abnormality of the dental root (HP:0006486)2.55933569
66Taurodontia (HP:0000679)2.55933569
67Abnormality of the renal medulla (HP:0100957)2.51265372
68Posterior embryotoxon (HP:0000627)2.50952825
69Gonadotropin excess (HP:0000837)2.49291921
70Hypergammaglobulinemia (HP:0010702)2.40530187
71Tubular atrophy (HP:0000092)2.36468758
72Abnormality of the line of Schwalbe (HP:0008048)2.36422196
73Megalocornea (HP:0000485)2.32454838
74Abnormality of molar morphology (HP:0011070)2.32303523
75Abnormality of molar (HP:0011077)2.32303523
76Facial cleft (HP:0002006)2.31101129
77Recurrent sinusitis (HP:0011108)2.30887601
78Long foot (HP:0001833)2.27858485
79Testicular atrophy (HP:0000029)2.26988212
80Abnormality of the dental pulp (HP:0006479)2.26412994
81Skin pits (HP:0100276)2.26093924
82Multiple enchondromatosis (HP:0005701)2.23959409
83Degeneration of anterior horn cells (HP:0002398)2.21828697
84Abnormality of the anterior horn cell (HP:0006802)2.21828697
85Abnormality of the lower motor neuron (HP:0002366)2.21397954
86Mask-like facies (HP:0000298)2.19167311
87Aplasia/hypoplasia of the humerus (HP:0006507)2.17407223
88Hepatic necrosis (HP:0002605)2.14532071
89Amyotrophic lateral sclerosis (HP:0007354)2.12670095
90Abnormality of midbrain morphology (HP:0002418)2.11921399
91Molar tooth sign on MRI (HP:0002419)2.11921399
92Back pain (HP:0003418)2.10190958
93Neutropenia (HP:0001875)2.09996955
94Cellulitis (HP:0100658)2.08210752
95Abnormality of the anterior chamber (HP:0000593)2.06779420
96Short humerus (HP:0005792)2.04671141
97Urticaria (HP:0001025)2.03970935
98Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03830510
99Reduced subcutaneous adipose tissue (HP:0003758)2.03061020
100Neck muscle weakness (HP:0000467)2.01403723
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.2724213
102Absent/shortened dynein arms (HP:0200106)10.6891502
103Dynein arm defect of respiratory motile cilia (HP:0012255)10.6891502
104Ectropion (HP:0000656)1.98983793
105Morphological abnormality of the inner ear (HP:0011390)1.95418201
106Congenital primary aphakia (HP:0007707)1.94809611
107Selective tooth agenesis (HP:0001592)1.94461461
108Short thorax (HP:0010306)1.94258958
109Respiratory failure (HP:0002878)1.94074575
110Gait imbalance (HP:0002141)1.93779745
111Abnormality of the pupil (HP:0000615)1.93428207
112Shawl scrotum (HP:0000049)1.92811464
113Abnormal eating behavior (HP:0100738)1.92422964
114Increased muscle lipid content (HP:0009058)1.92250496
115Hepatocellular necrosis (HP:0001404)1.87993520
116Preauricular skin tag (HP:0000384)1.87186718
117Tubulointerstitial nephritis (HP:0001970)1.84744098
118Precocious puberty (HP:0000826)1.83482398
119Hypertriglyceridemia (HP:0002155)1.81249505
120Growth hormone excess (HP:0000845)1.80524459
121Coarctation of aorta (HP:0001680)1.80182820
122Fibular hypoplasia (HP:0003038)1.77833535
123Skin tags (HP:0010609)1.77187381
124Vaginal atresia (HP:0000148)1.73244261
125Short ribs (HP:0000773)1.72476651
126Tubulointerstitial abnormality (HP:0001969)1.71438515
127Azoospermia (HP:0000027)1.70550110
128Recurrent bronchitis (HP:0002837)1.69453128
129Gowers sign (HP:0003391)1.68987336
130Genital tract atresia (HP:0001827)1.66151806
131Mitochondrial inheritance (HP:0001427)1.65777920
132Asplenia (HP:0001746)1.65415824
133Abnormal ventriculo-arterial connection (HP:0011563)1.64788854
134Transposition of the great arteries (HP:0001669)1.64788854
135Abnormal connection of the cardiac segments (HP:0011545)1.64788854
136Dicarboxylic aciduria (HP:0003215)1.64395427
137Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64395427
138Broad nasal tip (HP:0000455)1.64188625
139Absent radius (HP:0003974)1.62195496
140Postaxial foot polydactyly (HP:0001830)1.62081992
141Nephrogenic diabetes insipidus (HP:0009806)1.60902246
142Carpal bone hypoplasia (HP:0001498)1.60063498
143Delayed gross motor development (HP:0002194)1.59724998
144Oculomotor apraxia (HP:0000657)1.58538174
145Abnormal mitochondria in muscle tissue (HP:0008316)1.58001026
146Calf muscle hypertrophy (HP:0008981)1.55641281
14711 pairs of ribs (HP:0000878)1.55560008
148Cleft eyelid (HP:0000625)1.55182155
149Muscle hypertrophy of the lower extremities (HP:0008968)1.54361234
150Vertebral fusion (HP:0002948)1.54282728
151Renal dysplasia (HP:0000110)1.53914179
152Muscle fiber atrophy (HP:0100295)1.53875833
153Anomalous pulmonary venous return (HP:0010772)1.53834361
154Opisthotonus (HP:0002179)1.53804865
155Cerebellar dysplasia (HP:0007033)1.53648838
156Breast aplasia (HP:0100783)1.53543537
157Personality changes (HP:0000751)1.53112279
158Abnormal gallbladder physiology (HP:0012438)1.53053802
159Cholecystitis (HP:0001082)1.53053802
160Hypodontia (HP:0000668)1.52516527
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52137166
162Absent epiphyses (HP:0010577)1.52137166
163Abnormality of aromatic amino acid family metabolism (HP:0004338)1.51963155
164Type II lissencephaly (HP:0007260)1.51382809
165Sensory axonal neuropathy (HP:0003390)1.51321777
166Aplasia involving forearm bones (HP:0009822)1.50942967
167Absent forearm bone (HP:0003953)1.50942967
168Tubulointerstitial fibrosis (HP:0005576)1.50886776
169Exercise-induced myalgia (HP:0003738)1.50296555
170Cerebral palsy (HP:0100021)1.50129630
171Acanthosis nigricans (HP:0000956)1.49811569
172Lactic acidosis (HP:0003128)1.47878897
173Renal duplication (HP:0000075)1.47615867
174Truncal ataxia (HP:0002078)1.46423815
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.45515428
176Aplasia/Hypoplasia of the lens (HP:0008063)1.45416920
177Non-midline cleft lip (HP:0100335)1.45354520
178Increased intramyocellular lipid droplets (HP:0012240)1.44816389
179Abnormality of the pulmonary veins (HP:0011718)1.44814739
180Abnormal lung lobation (HP:0002101)1.44499995
181Renal Fanconi syndrome (HP:0001994)1.44048726
182Anosmia (HP:0000458)1.42942697
183Microretrognathia (HP:0000308)1.42801105
184Hemivertebrae (HP:0002937)1.42679229
185Aplasia/Hypoplasia of the breasts (HP:0010311)1.42575653
186Postaxial hand polydactyly (HP:0001162)1.41099700
187Mildly elevated creatine phosphokinase (HP:0008180)1.41084165
188Atrophy/Degeneration involving motor neurons (HP:0007373)1.40287696
189Abnormality of dentin (HP:0010299)1.39139070
190Retinal dysplasia (HP:0007973)1.38991178
191Microdontia (HP:0000691)1.38139207
192Acute necrotizing encephalopathy (HP:0006965)1.37820153
193Lethargy (HP:0001254)1.35278155
194Nonprogressive disorder (HP:0003680)1.34485908
195Abnormality of the phalanges of the hallux (HP:0010057)1.33573267
196Short femoral neck (HP:0100864)1.33339918
197Dental malocclusion (HP:0000689)1.31957007
198Leukocytosis (HP:0001974)1.31944145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS26.65876262
2PDK36.49997644
3PDK46.49997644
4PIK3CA6.18142620
5TESK14.88737785
6CAMK1D4.74701743
7PDK24.22119817
8CAMK1G3.56773147
9PRKD33.41300620
10CDK193.39909368
11ICK2.96616139
12PNCK2.68490343
13PASK2.45883564
14ARAF2.38284251
15PLK42.28233382
16CAMKK22.24710845
17MAP3K62.11663394
18NEK22.04718915
19WEE12.01644259
20TESK21.98882366
21CDC71.87196501
22MAPK121.84241647
23MAP3K111.80744996
24RET1.80422139
25PTK21.69585029
26NME21.65887653
27BUB11.63660242
28PIM21.55110549
29MOS1.44793028
30OXSR11.39686332
31WNK41.37744942
32EIF2AK11.33335375
33PTK2B1.31806290
34MAP2K41.29669258
35STK391.29667795
36KIT1.25277149
37GRK71.24686464
38DYRK31.23332493
39BMPR21.19690737
40GRK51.17441867
41TAOK11.15185847
42TGFBR11.10295896
43BCKDK1.09945160
44TRIB31.08601706
45DYRK1B1.04994824
46CAMKK11.04696379
47PAK41.03968595
48STK380.99913217
49TNK20.98392622
50CDK120.96719443
51TTK0.96418990
52CAMK10.95963364
53IRAK30.94331218
54MAP3K100.92370551
55SRPK10.88095071
56TGFBR20.87681885
57CCNB10.85583474
58PAK10.84113941
59LIMK10.82858293
60KDR0.80592563
61PLK10.79867155
62PHKG20.79072847
63PHKG10.79072847
64PDGFRB0.78363879
65CHEK10.77343692
66CHEK20.75509556
67MINK10.74326125
68ATR0.71306415
69CDK80.69166258
70ERN10.68699546
71VRK10.66477593
72NLK0.66074060
73MKNK10.65909553
74CDK70.62989190
75INSRR0.61781595
76PRKCI0.60858907
77MAP3K80.57939921
78PRKD10.55448885
79IRAK20.53640369
80TYRO30.53410347
81STK110.53140437
82STK30.53018194
83ABL20.52957279
84AKT20.51796450
85TSSK60.51586160
86IRAK10.51559373
87PKN20.51173118
88ATM0.50301407
89PLK30.50007021
90VRK20.49073269
91AURKA0.48385918
92CSNK1G30.47998053
93TLK10.47833379
94RPS6KA40.47299352
95OBSCN0.46708686
96PDK10.45219497
97STK100.44536333
98AURKB0.43732649
99ADRBK10.42435917
100EPHB20.42411116
101PRKAA10.40915330
102MTOR0.40868329
103LATS10.40123967
104NEK10.39986539
105STK38L0.39530228
106EEF2K0.39312874
107CAMK40.38162811
108PINK10.37384851
109CSNK2A10.37020130
110CSNK1E0.36441118
111EPHA20.34717710
112DAPK30.34500771
113MAPK150.33632417
114CDK20.32888174
115CSNK2A20.32815062
116CSNK1A1L0.32348603
117CASK0.32336721
118BMPR1B0.31864468
119EIF2AK30.31113181
120BRSK20.29605189
121PRKG10.29287164
122CAMK2G0.28353329
123TAOK20.27891299
124CSNK1G20.26493746
125MAP2K60.25923221
126SMG10.25295021
127SIK10.25030733
128BRAF0.24718992
129BRD40.24529253
130PRKAA20.24418870
131CDK40.23338285
132BRSK10.23192941
133WNK10.22433026
134CDK10.22072377
135FGFR10.21859647
136SCYL20.21362267
137YES10.20419979
138PRKD20.20295616
139CDK140.20214802
140MAP3K50.20154999
141CSNK1G10.19810642
142CDK60.19582528
143CDK150.19518529
144AKT30.19245419
145CDK11A0.18792871
146ILK0.18152296
147ALK0.17928333
148DYRK20.17525832
149MAP2K20.17303661
150RPS6KA50.17206303
151CDK50.16613329
152CDK180.15654701
153MAP3K90.14831008
154PRKACA0.14210133
155CAMK2A0.13681805
156PRKDC0.12849642
157CAMK2B0.12608019
158GRK60.12222143
159MAP3K30.11821668
160PDPK10.11818496
161RPS6KA10.11166365
162MARK10.11157527
163LRRK20.11155692
164MAP2K30.11117256
165MAP2K70.11001038
166GSK3B0.10848932
167PRKCG0.10679489
168MAP3K20.08255711
169TTN0.08016545
170MARK20.07339874

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.69732772
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.62046810
3African trypanosomiasis_Homo sapiens_hsa051433.31914140
4DNA replication_Homo sapiens_hsa030303.18256390
5RNA transport_Homo sapiens_hsa030133.10589924
6Pyruvate metabolism_Homo sapiens_hsa006202.88991161
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.84105039
8Vitamin B6 metabolism_Homo sapiens_hsa007502.82967934
9Selenocompound metabolism_Homo sapiens_hsa004502.76447753
10Spliceosome_Homo sapiens_hsa030402.74612135
11Basal transcription factors_Homo sapiens_hsa030222.66265781
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38765846
13Proteasome_Homo sapiens_hsa030502.37816667
14Mismatch repair_Homo sapiens_hsa034302.32046596
15Fatty acid elongation_Homo sapiens_hsa000622.25774844
16One carbon pool by folate_Homo sapiens_hsa006702.20884257
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09466249
18Oocyte meiosis_Homo sapiens_hsa041142.08607343
19Pyrimidine metabolism_Homo sapiens_hsa002402.05747856
20Fatty acid biosynthesis_Homo sapiens_hsa000611.99672140
21Propanoate metabolism_Homo sapiens_hsa006401.97532589
22Linoleic acid metabolism_Homo sapiens_hsa005911.96091791
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92381666
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.91245553
25Glucagon signaling pathway_Homo sapiens_hsa049221.88284887
26mRNA surveillance pathway_Homo sapiens_hsa030151.85042787
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84755529
28Fanconi anemia pathway_Homo sapiens_hsa034601.83440030
29RNA polymerase_Homo sapiens_hsa030201.82348800
30Ribosome_Homo sapiens_hsa030101.75770390
31Biosynthesis of amino acids_Homo sapiens_hsa012301.75441983
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73205008
33Hedgehog signaling pathway_Homo sapiens_hsa043401.73118951
34Sulfur relay system_Homo sapiens_hsa041221.66933135
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64720444
36Carbon metabolism_Homo sapiens_hsa012001.63740440
37Basal cell carcinoma_Homo sapiens_hsa052171.63029486
38Pentose phosphate pathway_Homo sapiens_hsa000301.62711057
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58063927
40Homologous recombination_Homo sapiens_hsa034401.50027875
41Huntingtons disease_Homo sapiens_hsa050161.49883369
42Base excision repair_Homo sapiens_hsa034101.49777868
43Cell cycle_Homo sapiens_hsa041101.48777262
44Purine metabolism_Homo sapiens_hsa002301.48152405
45Nucleotide excision repair_Homo sapiens_hsa034201.38864508
46Renin-angiotensin system_Homo sapiens_hsa046141.29840210
47Retinol metabolism_Homo sapiens_hsa008301.29799985
48Fat digestion and absorption_Homo sapiens_hsa049751.29060126
49AMPK signaling pathway_Homo sapiens_hsa041521.24429456
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24318269
51Systemic lupus erythematosus_Homo sapiens_hsa053221.18011053
52Tryptophan metabolism_Homo sapiens_hsa003801.10039150
53Glycerolipid metabolism_Homo sapiens_hsa005611.08635192
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06414473
55Type II diabetes mellitus_Homo sapiens_hsa049301.05744980
56RNA degradation_Homo sapiens_hsa030181.05685228
57Folate biosynthesis_Homo sapiens_hsa007901.04512669
58Allograft rejection_Homo sapiens_hsa053301.03725156
59Autoimmune thyroid disease_Homo sapiens_hsa053201.02405187
60Glutathione metabolism_Homo sapiens_hsa004801.01405321
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.00923900
62Alzheimers disease_Homo sapiens_hsa050100.95035663
63Synaptic vesicle cycle_Homo sapiens_hsa047210.89556181
64Tyrosine metabolism_Homo sapiens_hsa003500.88852997
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88065094
66Type I diabetes mellitus_Homo sapiens_hsa049400.87490653
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84935043
68Cardiac muscle contraction_Homo sapiens_hsa042600.83315236
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82546668
70beta-Alanine metabolism_Homo sapiens_hsa004100.82191129
71Graft-versus-host disease_Homo sapiens_hsa053320.82105462
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81945678
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80493112
74Adherens junction_Homo sapiens_hsa045200.78084659
75Fructose and mannose metabolism_Homo sapiens_hsa000510.77022780
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76801012
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.76706965
78Amphetamine addiction_Homo sapiens_hsa050310.75668713
79Hippo signaling pathway_Homo sapiens_hsa043900.75510664
80p53 signaling pathway_Homo sapiens_hsa041150.75456836
81Antigen processing and presentation_Homo sapiens_hsa046120.74414289
82Nicotine addiction_Homo sapiens_hsa050330.72330610
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72214627
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.71317042
85VEGF signaling pathway_Homo sapiens_hsa043700.69024191
86Insulin signaling pathway_Homo sapiens_hsa049100.68945124
87N-Glycan biosynthesis_Homo sapiens_hsa005100.68429823
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67329931
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67192769
90Wnt signaling pathway_Homo sapiens_hsa043100.65905925
91PPAR signaling pathway_Homo sapiens_hsa033200.64803147
92cAMP signaling pathway_Homo sapiens_hsa040240.64199512
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64093508
94FoxO signaling pathway_Homo sapiens_hsa040680.62739486
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61779239
96Legionellosis_Homo sapiens_hsa051340.60778577
97Ether lipid metabolism_Homo sapiens_hsa005650.60777654
98mTOR signaling pathway_Homo sapiens_hsa041500.60293357
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60214920
100Phenylalanine metabolism_Homo sapiens_hsa003600.59489053
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56209000
102Insulin resistance_Homo sapiens_hsa049310.56138739
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.56037791
104Epstein-Barr virus infection_Homo sapiens_hsa051690.55267537
105Melanoma_Homo sapiens_hsa052180.55047515
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55025324
107Alcoholism_Homo sapiens_hsa050340.53768579
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52797120
109Peroxisome_Homo sapiens_hsa041460.52400597
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52380317
111Dorso-ventral axis formation_Homo sapiens_hsa043200.50235679
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46826537
113Metabolic pathways_Homo sapiens_hsa011000.46723566
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46416565
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46264064
116Viral carcinogenesis_Homo sapiens_hsa052030.44919683
117HTLV-I infection_Homo sapiens_hsa051660.44869327
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43995332
119Glioma_Homo sapiens_hsa052140.42019220
120Cholinergic synapse_Homo sapiens_hsa047250.41935683
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38504092
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37721439
123Long-term potentiation_Homo sapiens_hsa047200.37564566
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37337452
125Mineral absorption_Homo sapiens_hsa049780.37133008
126Arginine and proline metabolism_Homo sapiens_hsa003300.37114446
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36847176
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36067391
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35949050
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.35327892
131Non-homologous end-joining_Homo sapiens_hsa034500.34908331
132Acute myeloid leukemia_Homo sapiens_hsa052210.33711824
133Butanoate metabolism_Homo sapiens_hsa006500.32988601
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.32381888
135Fatty acid metabolism_Homo sapiens_hsa012120.31442120
136Fatty acid degradation_Homo sapiens_hsa000710.31395181
137Arginine biosynthesis_Homo sapiens_hsa002200.31058323
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30709776
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30235083
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29856738
141Renal cell carcinoma_Homo sapiens_hsa052110.29033854
142ErbB signaling pathway_Homo sapiens_hsa040120.28684170
143Melanogenesis_Homo sapiens_hsa049160.27748528
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26933347
145Estrogen signaling pathway_Homo sapiens_hsa049150.26393164
146Thyroid cancer_Homo sapiens_hsa052160.26160723
147Parkinsons disease_Homo sapiens_hsa050120.25048669
148Calcium signaling pathway_Homo sapiens_hsa040200.25038392
149Non-small cell lung cancer_Homo sapiens_hsa052230.24685529
150Chemical carcinogenesis_Homo sapiens_hsa052040.24419949
151Pancreatic cancer_Homo sapiens_hsa052120.24101907
152Oxytocin signaling pathway_Homo sapiens_hsa049210.23774838
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23612051
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22411370
155Oxidative phosphorylation_Homo sapiens_hsa001900.19456243
156TGF-beta signaling pathway_Homo sapiens_hsa043500.16401825
157Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16189338
158Renin secretion_Homo sapiens_hsa049240.15248371
159Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13893059
160Arachidonic acid metabolism_Homo sapiens_hsa005900.12938666

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