MESP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.45824644
2protein localization to kinetochore (GO:0034501)5.93539073
3negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.86705352
4regulation of mammary gland epithelial cell proliferation (GO:0033599)5.85621626
5maintenance of protein location in nucleus (GO:0051457)5.85061621
6negative regulation of epidermis development (GO:0045683)5.73317198
7regulation of telomere maintenance via telomerase (GO:0032210)5.70628412
8regulation of nuclear cell cycle DNA replication (GO:0033262)5.67679986
9positive regulation of DNA-dependent DNA replication (GO:2000105)5.45803810
10mitotic sister chromatid segregation (GO:0000070)5.36816715
11piRNA metabolic process (GO:0034587)5.33185151
12notochord development (GO:0030903)5.23560141
13negative regulation of cell cycle G2/M phase transition (GO:1902750)5.23384356
14rRNA transcription (GO:0009303)5.22146396
15seminiferous tubule development (GO:0072520)5.22017320
16regulation of response to osmotic stress (GO:0047484)5.16552383
17respiratory chain complex IV assembly (GO:0008535)4.92069131
18rRNA methylation (GO:0031167)4.88072359
19negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.86654222
20negative regulation of telomerase activity (GO:0051974)4.85083914
21regulation of meiosis I (GO:0060631)4.84568920
22negative regulation of epidermal cell differentiation (GO:0045605)4.74600883
23DNA deamination (GO:0045006)4.74077551
24DNA replication checkpoint (GO:0000076)4.71465451
25protein localization to chromosome, centromeric region (GO:0071459)4.68425627
26regulation of MHC class I biosynthetic process (GO:0045343)4.66143114
27histone H4-K8 acetylation (GO:0043982)4.65412272
28histone H4-K5 acetylation (GO:0043981)4.65412272
29histone H4-K12 acetylation (GO:0043983)4.64874873
30muscle organ morphogenesis (GO:0048644)4.59518460
31regulation of cilium movement (GO:0003352)4.54724219
32negative regulation of telomere maintenance (GO:0032205)4.49636143
33rRNA modification (GO:0000154)4.48210479
34interferon-gamma production (GO:0032609)4.42318031
35sister chromatid segregation (GO:0000819)4.36025591
36* somite rostral/caudal axis specification (GO:0032525)4.26556855
37regulation of memory T cell differentiation (GO:0043380)4.11514451
38indolalkylamine catabolic process (GO:0046218)4.09969209
39tryptophan catabolic process (GO:0006569)4.09969209
40indole-containing compound catabolic process (GO:0042436)4.09969209
41cytochrome complex assembly (GO:0017004)4.07712107
42regulation of translation in response to stress (GO:0043555)4.03599248
43DNA replication-dependent nucleosome organization (GO:0034723)4.03048957
44DNA replication-dependent nucleosome assembly (GO:0006335)4.03048957
45tryptophan metabolic process (GO:0006568)4.02286210
46nuclear pore complex assembly (GO:0051292)3.98828529
47primitive streak formation (GO:0090009)3.95739055
48sex differentiation (GO:0007548)3.94906679
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94640904
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.94640904
51NADH dehydrogenase complex assembly (GO:0010257)3.94640904
52kynurenine metabolic process (GO:0070189)3.91056712
53cytidine deamination (GO:0009972)3.89175201
54cytidine metabolic process (GO:0046087)3.89175201
55cytidine catabolic process (GO:0006216)3.89175201
56mitotic chromosome condensation (GO:0007076)3.88148521
57protein complex biogenesis (GO:0070271)3.86248210
58detection of light stimulus involved in sensory perception (GO:0050962)3.84026855
59detection of light stimulus involved in visual perception (GO:0050908)3.84026855
60quinone metabolic process (GO:1901661)3.77396186
61chromatin assembly (GO:0031497)3.76217703
62indolalkylamine metabolic process (GO:0006586)3.75636613
63protein K6-linked ubiquitination (GO:0085020)3.71850187
64microtubule severing (GO:0051013)3.70007395
65mitochondrial respiratory chain complex assembly (GO:0033108)3.69274780
66replication fork processing (GO:0031297)3.69269000
67heterochromatin organization (GO:0070828)3.67625047
68intestinal epithelial cell development (GO:0060576)3.67560606
69negative regulation of multicellular organism growth (GO:0040015)3.67365164
70regulation of apoptotic process involved in morphogenesis (GO:1902337)3.63267707
71nucleoside transmembrane transport (GO:1901642)3.60891631
72phenol-containing compound catabolic process (GO:0019336)3.60260747
73hormone catabolic process (GO:0042447)3.59217572
74regulation of action potential (GO:0098900)3.58541171
75protein deneddylation (GO:0000338)3.55158358
76DNA double-strand break processing (GO:0000729)3.54449654
77intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.50409649
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46949555
79DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.46322375
80histone H4-K16 acetylation (GO:0043984)3.42981561
81DNA methylation involved in gamete generation (GO:0043046)3.42967415
82nuclear pore organization (GO:0006999)3.42429419
83branching involved in mammary gland duct morphogenesis (GO:0060444)3.33928508
84protein localization to cilium (GO:0061512)3.33234297
85proline transport (GO:0015824)3.32700848
86regulation of telomere maintenance (GO:0032204)3.32040656
87protein polyglutamylation (GO:0018095)3.30925808
88mitochondrion distribution (GO:0048311)3.30577421
89response to pheromone (GO:0019236)3.29861985
90cullin deneddylation (GO:0010388)3.29245244
91DNA damage response, signal transduction resulting in transcription (GO:0042772)3.28781357
92regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.28076293
93regulation of DNA-dependent DNA replication (GO:0090329)3.22818504
94metallo-sulfur cluster assembly (GO:0031163)3.22253596
95iron-sulfur cluster assembly (GO:0016226)3.22253596
96preassembly of GPI anchor in ER membrane (GO:0016254)3.21939288
97ubiquinone biosynthetic process (GO:0006744)3.20919677
98positive regulation of male gonad development (GO:2000020)3.20553986
99response to dietary excess (GO:0002021)3.19585042
100coenzyme catabolic process (GO:0009109)3.19355646
101maintenance of protein localization in organelle (GO:0072595)3.19344453
102DNA demethylation (GO:0080111)3.16727331
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11429317
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11369359
105tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11369359
106intraciliary transport (GO:0042073)3.10713505
107mannosylation (GO:0097502)3.09954749
108mitotic G2/M transition checkpoint (GO:0044818)3.08622455
109icosanoid secretion (GO:0032309)3.08435450
110arachidonic acid secretion (GO:0050482)3.08435450
111pore complex assembly (GO:0046931)3.06919751
112negative regulation of meiosis (GO:0045835)3.06232615
113mitotic metaphase plate congression (GO:0007080)3.05363383
114platelet dense granule organization (GO:0060155)3.04898042
115regulation of double-strand break repair (GO:2000779)3.03861068
116glycine transport (GO:0015816)3.02928010
117regulation of telomerase activity (GO:0051972)3.02079080
118proteasome assembly (GO:0043248)2.98140484
119behavioral response to nicotine (GO:0035095)2.95912815
120cellular biogenic amine catabolic process (GO:0042402)2.95818392
121amine catabolic process (GO:0009310)2.95818392
122tachykinin receptor signaling pathway (GO:0007217)2.94287462
123cell wall macromolecule catabolic process (GO:0016998)2.93957722
124cornea development in camera-type eye (GO:0061303)2.93523562
125positive regulation of defense response to virus by host (GO:0002230)2.91943654
126nucleoside transport (GO:0015858)2.91586018
127attachment of spindle microtubules to kinetochore (GO:0008608)2.91208921
128mitochondrial RNA metabolic process (GO:0000959)2.90960337
129short-chain fatty acid metabolic process (GO:0046459)2.90354374
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.89868409
131male meiosis I (GO:0007141)2.89192902
132vitamin A metabolic process (GO:0006776)2.88867852
133cell fate commitment involved in formation of primary germ layer (GO:0060795)2.88304545
134pseudouridine synthesis (GO:0001522)2.87848686
135negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.87486864
136meiotic cell cycle (GO:0051321)2.87102218
137pre-miRNA processing (GO:0031054)2.86722947
138GPI anchor metabolic process (GO:0006505)2.85667359
139phosphatidylinositol acyl-chain remodeling (GO:0036149)2.84698521
140negative regulation of signal transduction by p53 class mediator (GO:1901797)2.84127206
141mRNA stabilization (GO:0048255)2.83271858
142RNA stabilization (GO:0043489)2.83271858
143positive regulation of DNA repair (GO:0045739)2.83162976
144regulation of male gonad development (GO:2000018)2.79690150
145phagocytosis, recognition (GO:0006910)2.79476031
146ribosome biogenesis (GO:0042254)2.78340213
147retinoic acid receptor signaling pathway (GO:0048384)2.78187493
148ubiquinone metabolic process (GO:0006743)2.77585656
149transepithelial transport (GO:0070633)2.77188133
150L-methionine salvage (GO:0071267)2.76767740
151L-methionine biosynthetic process (GO:0071265)2.76767740
152amino acid salvage (GO:0043102)2.76767740
153regulation of mitochondrial translation (GO:0070129)2.75394434
154adaptation of signaling pathway (GO:0023058)2.73659950
155histone H3-K4 methylation (GO:0051568)2.73417952
156double-strand break repair via homologous recombination (GO:0000724)2.72493399
157protein localization to chromosome (GO:0034502)2.72338027
158translesion synthesis (GO:0019985)2.72329359
159pyrimidine ribonucleoside catabolic process (GO:0046133)2.71990919
160recombinational repair (GO:0000725)2.71481368
161GDP-mannose metabolic process (GO:0019673)2.71210958
162nonmotile primary cilium assembly (GO:0035058)2.70872421
163mitochondrial DNA replication (GO:0006264)2.70081001
164negative regulation of interleukin-2 production (GO:0032703)2.68228699
165DNA dealkylation (GO:0035510)2.68013964
166positive regulation of meiosis (GO:0045836)2.66521168
167DNA catabolic process, exonucleolytic (GO:0000738)2.64863043
168estrogen biosynthetic process (GO:0006703)2.64832698
169chromatin remodeling at centromere (GO:0031055)2.64084321
170male meiosis (GO:0007140)2.63981995
171maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63892471
172limb bud formation (GO:0060174)2.63660706
173gonadal mesoderm development (GO:0007506)2.63458689
174somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60866678
175somatic hypermutation of immunoglobulin genes (GO:0016446)2.60866678
176quinone biosynthetic process (GO:1901663)2.60147926
177detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59980686
178regulation of glucokinase activity (GO:0033131)2.59310533
179regulation of hexokinase activity (GO:1903299)2.59310533
180meiotic chromosome segregation (GO:0045132)2.58836719
181indole-containing compound metabolic process (GO:0042430)2.58500822
182cell wall macromolecule metabolic process (GO:0044036)2.55731808
183neural tube formation (GO:0001841)2.52854670
184aromatic amino acid family catabolic process (GO:0009074)2.52583123
185sympathetic nervous system development (GO:0048485)2.50873206
186positive regulation of meiotic cell cycle (GO:0051446)2.50364070
187protein prenylation (GO:0018342)2.49714354
188prenylation (GO:0097354)2.49714354
189protein-cofactor linkage (GO:0018065)2.48873498
190tRNA processing (GO:0008033)2.42438099
191regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40943547
192negative regulation of mast cell activation (GO:0033004)2.39930548
193positive regulation of triglyceride biosynthetic process (GO:0010867)2.39916776
194C-terminal protein amino acid modification (GO:0018410)2.39908891
195polyketide metabolic process (GO:0030638)10.2841011
196doxorubicin metabolic process (GO:0044598)10.2841011
197daunorubicin metabolic process (GO:0044597)10.2841011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.25054830
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.03048555
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.03048555
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.03048555
5E2F7_22180533_ChIP-Seq_HELA_Human5.61861501
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.22115718
7TP63_19390658_ChIP-ChIP_HaCaT_Human4.08864854
8ZNF274_21170338_ChIP-Seq_K562_Hela3.79282497
9VDR_22108803_ChIP-Seq_LS180_Human3.56766638
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.22585310
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00063752
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.94868393
13GBX2_23144817_ChIP-Seq_PC3_Human2.90489803
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.81886097
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71935558
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70266409
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.62399796
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55401371
19* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.44923684
20IRF1_19129219_ChIP-ChIP_H3396_Human2.38288510
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35393042
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28301989
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.27541052
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25161259
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16714273
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.12289426
27* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.07696144
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.01233556
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.00980433
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00558461
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97562294
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90438257
33NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.89728520
34FUS_26573619_Chip-Seq_HEK293_Human1.88763816
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88336450
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83783411
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78852478
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.77744052
39EWS_26573619_Chip-Seq_HEK293_Human1.74479150
40P300_19829295_ChIP-Seq_ESCs_Human1.73336040
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71608248
42TP53_22573176_ChIP-Seq_HFKS_Human1.69863117
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.68896288
44MYC_18940864_ChIP-ChIP_HL60_Human1.68713459
45ER_23166858_ChIP-Seq_MCF-7_Human1.68412961
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67330010
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67228121
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66496563
49TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.61497997
50CBP_20019798_ChIP-Seq_JUKART_Human1.60943986
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60943986
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52083213
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52046000
54POU5F1_16518401_ChIP-PET_MESCs_Mouse1.48569102
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44868763
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44385289
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.43470990
58VDR_23849224_ChIP-Seq_CD4+_Human1.42642801
59PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.41230391
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40897032
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39335279
62* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39218646
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38476477
64NANOG_18692474_ChIP-Seq_MESCs_Mouse1.38476293
65ELK1_19687146_ChIP-ChIP_HELA_Human1.38174398
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.38116758
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36765491
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36429456
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31512831
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30886788
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29129676
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28297975
73NCOR_22424771_ChIP-Seq_293T_Human1.28056468
74RNF2_27304074_Chip-Seq_NSC_Mouse1.27713191
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27389563
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27056822
77BCAT_22108803_ChIP-Seq_LS180_Human1.26512117
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26274274
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.26274274
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23984026
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23394412
82E2F1_17053090_ChIP-ChIP_MCF-7_Human1.23327006
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23150168
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22923735
85TAF15_26573619_Chip-Seq_HEK293_Human1.22604814
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22390371
87HTT_18923047_ChIP-ChIP_STHdh_Human1.21736743
88EZH2_22144423_ChIP-Seq_EOC_Human1.21473805
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20304489
90NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20065143
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.19972731
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.19226180
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.19009360
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.17763803
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17760440
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16119604
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15692238
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.15340768
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15151473
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.15062074
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.13881142
102CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13736816
103* STAT3_23295773_ChIP-Seq_U87_Human1.13712554
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.13672919
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13402031
106ERA_21632823_ChIP-Seq_H3396_Human1.12931663
107AR_25329375_ChIP-Seq_VCAP_Human1.11291974
108NANOG_16518401_ChIP-PET_MESCs_Mouse1.11251476
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11053719
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09757558
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.09247996
112RUNX2_22187159_ChIP-Seq_PCA_Human1.08431516
113SOX2_19829295_ChIP-Seq_ESCs_Human1.08075590
114NANOG_19829295_ChIP-Seq_ESCs_Human1.08075590
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07493354
116TCF4_23295773_ChIP-Seq_U87_Human1.06851019
117TCF4_22108803_ChIP-Seq_LS180_Human1.06834929
118MYC_18555785_ChIP-Seq_MESCs_Mouse1.06731877
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.06600364
120SMAD4_21799915_ChIP-Seq_A2780_Human1.06163262
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05470060
122IGF1R_20145208_ChIP-Seq_DFB_Human1.05020761
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04376078
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04067846
125AR_20517297_ChIP-Seq_VCAP_Human1.04050063
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.02881994
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01664521
128TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00401879
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99811852
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.99804575
131AR_21909140_ChIP-Seq_LNCAP_Human0.99605849
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99418553
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99030038
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98950444
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.98486327
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97568106
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.97244479
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97237475
139* GABP_19822575_ChIP-Seq_HepG2_Human0.96873585
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.96395110
141OCT4_20526341_ChIP-Seq_ESCs_Human0.95330433
142* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94926657
143MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94841539
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.94566356
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94087910
146EST1_17652178_ChIP-ChIP_JURKAT_Human0.94044931
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92362851
148MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90969322
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.89326329
150GATA1_26923725_Chip-Seq_HPCs_Mouse0.88409530
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87773133
152STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87732742
153KAP1_27257070_Chip-Seq_ESCs_Mouse0.85597081
154ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85239787
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84405272
156SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84100392
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78327167
158TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77828118
159HOXB7_26014856_ChIP-Seq_BT474_Human0.76529558
160TBX3_20139965_ChIP-Seq_MESCs_Mouse0.75630185
161MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74702591
162KDM5A_27292631_Chip-Seq_BREAST_Human0.74389659
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74146526
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73989099
165SPI1_26923725_Chip-Seq_HPCs_Mouse0.73400525
166PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72709897
167* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71857520
168FOXP3_21729870_ChIP-Seq_TREG_Human0.70077070
169E2F1_18555785_ChIP-Seq_MESCs_Mouse0.69962071
170* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68631591
171SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67476117
172RUNX1_26923725_Chip-Seq_HPCs_Mouse0.67405924
173* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.66204839
174SALL1_21062744_ChIP-ChIP_HESCs_Human0.65985521
175SCL_19346495_ChIP-Seq_HPC-7_Human0.65798292
176KLF4_18555785_ChIP-Seq_MESCs_Mouse0.65736176
177NCOR1_26117541_ChIP-Seq_K562_Human0.65466556
178CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64875321
179ESET_19884257_ChIP-Seq_ESCs_Mouse0.64121161
180E2F1_21310950_ChIP-Seq_MCF-7_Human0.63991852
181CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63336895
182RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.63048425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.10528977
2MP0003011_delayed_dark_adaptation4.38464883
3MP0004264_abnormal_extraembryonic_tissu4.33107025
4MP0003890_abnormal_embryonic-extraembry3.66916234
5MP0002254_reproductive_system_inflammat3.62743950
6MP0001986_abnormal_taste_sensitivity3.55282063
7MP0008057_abnormal_DNA_replication3.20181075
8MP0005499_abnormal_olfactory_system3.08942412
9MP0005394_taste/olfaction_phenotype3.08942412
10MP0006072_abnormal_retinal_apoptosis3.07746809
11MP0002653_abnormal_ependyma_morphology3.03100563
12MP0005075_abnormal_melanosome_morpholog3.00461890
13MP0008877_abnormal_DNA_methylation2.95773540
14MP0004957_abnormal_blastocyst_morpholog2.75147246
15MP0005257_abnormal_intraocular_pressure2.61094554
16MP0005551_abnormal_eye_electrophysiolog2.60104399
17MP0002332_abnormal_exercise_endurance2.58186548
18MP0001968_abnormal_touch/_nociception2.53784539
19MP0003121_genomic_imprinting2.43594365
20MP0000569_abnormal_digit_pigmentation2.43137229
21MP0005646_abnormal_pituitary_gland2.38589985
22MP0000678_abnormal_parathyroid_gland2.30485040
23MP0002736_abnormal_nociception_after2.26593204
24MP0004858_abnormal_nervous_system2.18476163
25MP0002735_abnormal_chemical_nociception2.14550854
26MP0005367_renal/urinary_system_phenotyp2.10130528
27MP0000516_abnormal_urinary_system2.10130528
28MP0003122_maternal_imprinting2.07970125
29MP0002277_abnormal_respiratory_mucosa2.02126870
30MP0003077_abnormal_cell_cycle1.96653384
31MP0010094_abnormal_chromosome_stability1.94672334
32MP0005253_abnormal_eye_physiology1.91272001
33MP0003195_calcinosis1.90020007
34MP0008995_early_reproductive_senescence1.88150108
35MP0008872_abnormal_physiological_respon1.86241808
36MP0003787_abnormal_imprinting1.84443399
37MP0003123_paternal_imprinting1.83271398
38MP0003880_abnormal_central_pattern1.81088917
39MP0003938_abnormal_ear_development1.78544948
40MP0003111_abnormal_nucleus_morphology1.78514879
41MP0002837_dystrophic_cardiac_calcinosis1.77580867
42MP0010030_abnormal_orbit_morphology1.76204872
43MP0005380_embryogenesis_phenotype1.72349446
44MP0001672_abnormal_embryogenesis/_devel1.72349446
45MP0003806_abnormal_nucleotide_metabolis1.72206620
46MP0002234_abnormal_pharynx_morphology1.68154283
47MP0002822_catalepsy1.66820691
48MP0004885_abnormal_endolymph1.64461133
49MP0003183_abnormal_peptide_metabolism1.63155430
50MP0003693_abnormal_embryo_hatching1.62768630
51MP0003705_abnormal_hypodermis_morpholog1.56632251
52MP0005174_abnormal_tail_pigmentation1.56263472
53MP0010352_gastrointestinal_tract_polyps1.55032794
54MP0002088_abnormal_embryonic_growth/wei1.52609078
55MP0003984_embryonic_growth_retardation1.52370447
56MP0002127_abnormal_cardiovascular_syste1.51449856
57MP0005670_abnormal_white_adipose1.50785343
58MP0006082_CNS_inflammation1.49621603
59MP0002132_abnormal_respiratory_system1.48196079
60MP0008789_abnormal_olfactory_epithelium1.46737240
61MP0009745_abnormal_behavioral_response1.45347031
62MP0010386_abnormal_urinary_bladder1.44923813
63MP0008875_abnormal_xenobiotic_pharmacok1.44912343
64MP0006035_abnormal_mitochondrial_morpho1.43494579
65MP0002160_abnormal_reproductive_system1.43451864
66MP0002751_abnormal_autonomic_nervous1.42487760
67MP0005645_abnormal_hypothalamus_physiol1.39334172
68MP0000350_abnormal_cell_proliferation1.39042194
69MP0001501_abnormal_sleep_pattern1.37874024
70MP0001486_abnormal_startle_reflex1.37699998
71MP0003718_maternal_effect1.37171475
72MP0001293_anophthalmia1.34053684
73MP0000490_abnormal_crypts_of1.30795219
74MP0003252_abnormal_bile_duct1.28853928
75MP0005451_abnormal_body_composition1.28699894
76MP0000049_abnormal_middle_ear1.26443084
77MP0002233_abnormal_nose_morphology1.25134313
78MP0004782_abnormal_surfactant_physiolog1.24002003
79MP0001764_abnormal_homeostasis1.23707928
80MP0008007_abnormal_cellular_replicative1.23417417
81MP0004742_abnormal_vestibular_system1.20213403
82MP0005389_reproductive_system_phenotype1.20056970
83MP0002396_abnormal_hematopoietic_system1.15804706
84* MP0002085_abnormal_embryonic_tissue1.15794421
85MP0003755_abnormal_palate_morphology1.15516594
86MP0002938_white_spotting1.14680180
87MP0008932_abnormal_embryonic_tissue1.14257877
88MP0001529_abnormal_vocalization1.12562682
89MP0000762_abnormal_tongue_morphology1.12171182
90MP0005410_abnormal_fertilization1.10993997
91MP0000631_abnormal_neuroendocrine_gland1.10827512
92MP0003315_abnormal_perineum_morphology1.10597276
93MP0002086_abnormal_extraembryonic_tissu1.09963830
94MP0003698_abnormal_male_reproductive1.08757410
95MP0000639_abnormal_adrenal_gland1.08274420
96MP0003567_abnormal_fetal_cardiomyocyte1.07486156
97MP0000432_abnormal_head_morphology1.06806085
98MP0003937_abnormal_limbs/digits/tail_de1.06640953
99MP0002249_abnormal_larynx_morphology1.06304866
100MP0006036_abnormal_mitochondrial_physio1.05597828
101MP0002092_abnormal_eye_morphology1.04768517
102MP0004381_abnormal_hair_follicle1.04359645
103MP0005248_abnormal_Harderian_gland1.03758715
104MP0002272_abnormal_nervous_system1.03392913
105MP0004924_abnormal_behavior1.03337100
106MP0005386_behavior/neurological_phenoty1.03337100
107MP0008961_abnormal_basal_metabolism1.03204523
108MP0004147_increased_porphyrin_level1.02518677
109MP0001485_abnormal_pinna_reflex0.99877236
110MP0002572_abnormal_emotion/affect_behav0.98118763
111MP0002557_abnormal_social/conspecific_i0.98062513
112MP0003935_abnormal_craniofacial_develop0.97776746
113* MP0002932_abnormal_joint_morphology0.97592326
114MP0002734_abnormal_mechanical_nocicepti0.97506558
115MP0005266_abnormal_metabolism0.97298847
116MP0003943_abnormal_hepatobiliary_system0.96297447
117MP0001963_abnormal_hearing_physiology0.94889460
118MP0006276_abnormal_autonomic_nervous0.94095136
119MP0001849_ear_inflammation0.93787889
120MP0004019_abnormal_vitamin_homeostasis0.92686995
121MP0008058_abnormal_DNA_repair0.92584646
122MP0000427_abnormal_hair_cycle0.92541088
123MP0001970_abnormal_pain_threshold0.92321190
124MP0001119_abnormal_female_reproductive0.91697205
125MP0002229_neurodegeneration0.91637254
126* MP0002114_abnormal_axial_skeleton0.90730449
127MP0005195_abnormal_posterior_eye0.89304766
128MP0001905_abnormal_dopamine_level0.89255033
129MP0002282_abnormal_trachea_morphology0.88884757
130MP0000313_abnormal_cell_death0.88171891
131MP0003119_abnormal_digestive_system0.86872054
132MP0002102_abnormal_ear_morphology0.86492339
133MP0005310_abnormal_salivary_gland0.84724555
134MP0002116_abnormal_craniofacial_bone0.84667352
135* MP0002084_abnormal_developmental_patter0.84495538
136MP0002098_abnormal_vibrissa_morphology0.83283399
137MP0002163_abnormal_gland_morphology0.81691448
138MP0001324_abnormal_eye_pigmentation0.81663224
139MP0005379_endocrine/exocrine_gland_phen0.81532261
140MP0000383_abnormal_hair_follicle0.81470265
141MP0003646_muscle_fatigue0.81062551
142MP0005083_abnormal_biliary_tract0.79939021
143MP0001919_abnormal_reproductive_system0.79652652
144MP0005636_abnormal_mineral_homeostasis0.78957657
145MP0000428_abnormal_craniofacial_morphol0.78765279
146MP0003136_yellow_coat_color0.78528038
147MP0003786_premature_aging0.78114762
148* MP0002752_abnormal_somatic_nervous0.77857396
149MP0000647_abnormal_sebaceous_gland0.76030002
150MP0002210_abnormal_sex_determination0.75072716
151MP0001286_abnormal_eye_development0.74089437
152MP0001188_hyperpigmentation0.74021086
153MP0001145_abnormal_male_reproductive0.72957948
154MP0001730_embryonic_growth_arrest0.71445153
155MP0002970_abnormal_white_adipose0.71279516
156MP0005084_abnormal_gallbladder_morpholo0.70831985
157MP0010368_abnormal_lymphatic_system0.70773863
158* MP0001697_abnormal_embryo_size0.70494729
159MP0002184_abnormal_innervation0.69655882
160MP0002067_abnormal_sensory_capabilities0.68831719
161MP0001929_abnormal_gametogenesis0.68350500
162MP0005391_vision/eye_phenotype0.68039498
163MP0009053_abnormal_anal_canal0.67735021
164MP0003936_abnormal_reproductive_system0.67724464
165MP0003950_abnormal_plasma_membrane0.66308033
166MP0005197_abnormal_uvea_morphology0.65986147
167MP0004043_abnormal_pH_regulation0.65428057
168MP0002019_abnormal_tumor_incidence0.63568646
169* MP0002925_abnormal_cardiovascular_devel0.61020284
170MP0000653_abnormal_sex_gland0.60507432
171MP0002877_abnormal_melanocyte_morpholog0.60402160
172MP0002109_abnormal_limb_morphology0.59367870
173* MP0002080_prenatal_lethality0.59190621
174MP0000372_irregular_coat_pigmentation0.57641770
175MP0003186_abnormal_redox_activity0.55875331

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.55169047
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.50596978
3Hypochromic microcytic anemia (HP:0004840)5.32043682
4Chromsome breakage (HP:0040012)5.00656615
5Hepatoblastoma (HP:0002884)4.85183447
6Congenital stationary night blindness (HP:0007642)4.63580439
7Abnormal rod and cone electroretinograms (HP:0008323)4.54087909
8Hypoplasia of the fovea (HP:0007750)4.34828041
9Aplasia/Hypoplasia of the fovea (HP:0008060)4.34828041
10Severe visual impairment (HP:0001141)4.25521831
11Multiple enchondromatosis (HP:0005701)4.10407772
12Nephroblastoma (Wilms tumor) (HP:0002667)4.06362948
13Embryonal renal neoplasm (HP:0011794)3.81732133
14Abnormality of the lower motor neuron (HP:0002366)3.66651356
15Bifid tongue (HP:0010297)3.50717289
16Rhabdomyosarcoma (HP:0002859)3.48223362
17Abnormality of macular pigmentation (HP:0008002)3.44183318
18Abnormality of the fovea (HP:0000493)3.40240366
19Neoplasm of striated muscle (HP:0009728)3.39202998
20Meckel diverticulum (HP:0002245)3.37118953
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.34114864
22Ependymoma (HP:0002888)3.30339898
23Abnormal lung lobation (HP:0002101)3.26079784
24Rectal fistula (HP:0100590)3.22420283
25Rectovaginal fistula (HP:0000143)3.22420283
26Genetic anticipation (HP:0003743)3.22193966
27Shawl scrotum (HP:0000049)3.20282530
28Progressive cerebellar ataxia (HP:0002073)3.19147997
29Abnormality of the ileum (HP:0001549)3.16799635
30Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10751869
31True hermaphroditism (HP:0010459)3.07751525
32Intestinal fistula (HP:0100819)3.06170298
33Medial flaring of the eyebrow (HP:0010747)3.02768628
34Partial duplication of thumb phalanx (HP:0009944)3.00448743
35Hyperglycinuria (HP:0003108)2.98279225
36Abnormality of the phalanges of the hallux (HP:0010057)2.96322010
37Prostate neoplasm (HP:0100787)2.91965342
38Abnormality of chromosome segregation (HP:0002916)2.84429886
39Hepatocellular necrosis (HP:0001404)2.84174010
40Supernumerary spleens (HP:0009799)2.81113811
41Reduced antithrombin III activity (HP:0001976)2.80908949
42Hepatic necrosis (HP:0002605)2.80895307
43Fused cervical vertebrae (HP:0002949)2.76613449
44Aplasia/Hypoplasia of the macula (HP:0008059)2.76297985
45Testicular atrophy (HP:0000029)2.74575977
46Impulsivity (HP:0100710)2.71132248
47Periauricular skin pits (HP:0100277)2.69737990
48Preauricular pit (HP:0004467)2.69737990
49Gaze-evoked nystagmus (HP:0000640)2.68734110
50Molar tooth sign on MRI (HP:0002419)2.67833502
51Abnormality of midbrain morphology (HP:0002418)2.67833502
52Vaginal fistula (HP:0004320)2.65335297
53Congenital primary aphakia (HP:0007707)2.65153741
54Hyperglycinemia (HP:0002154)2.64828956
55Nasolacrimal duct obstruction (HP:0000579)2.63971296
56Gait imbalance (HP:0002141)2.62142157
57Abnormality of the salivary glands (HP:0010286)2.59297777
58Small intestinal stenosis (HP:0012848)2.58909345
59Duodenal stenosis (HP:0100867)2.58909345
60Pendular nystagmus (HP:0012043)2.57844286
61Increased CSF lactate (HP:0002490)2.57709002
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.57417461
63Nephrogenic diabetes insipidus (HP:0009806)2.56193813
64Pancreatic fibrosis (HP:0100732)2.53720475
65Partial duplication of the phalanx of hand (HP:0009999)2.53301674
66Nephronophthisis (HP:0000090)2.52179933
67Central scotoma (HP:0000603)2.51515939
68Pancreatic cysts (HP:0001737)2.50701642
69Abnormality of the preputium (HP:0100587)2.50068865
70Aplasia/hypoplasia of the humerus (HP:0006507)2.48115512
71Mitochondrial inheritance (HP:0001427)2.47679581
72Hypochromic anemia (HP:0001931)2.45328100
73Intestinal atresia (HP:0011100)2.43979828
74Abnormality of the renal cortex (HP:0011035)2.43878380
75Broad-based gait (HP:0002136)2.43627255
76Renal cortical cysts (HP:0000803)2.43349989
77Abnormality of the prostate (HP:0008775)2.43092548
78Abnormality of serine family amino acid metabolism (HP:0010894)2.42846938
79Abnormality of glycine metabolism (HP:0010895)2.42846938
80Short humerus (HP:0005792)2.41467313
81Acute necrotizing encephalopathy (HP:0006965)2.39719381
82Aplastic anemia (HP:0001915)2.38966267
83Short middle phalanx of the 5th finger (HP:0004220)2.38223470
84Abnormality of the distal phalanx of the thumb (HP:0009617)2.35844151
85Acute encephalopathy (HP:0006846)2.32392729
86Aplasia/Hypoplasia affecting the retina (HP:0008061)2.30921710
87Skin pits (HP:0100276)2.30071135
88Abnormality of chromosome stability (HP:0003220)2.30000982
89Preauricular skin tag (HP:0000384)2.29191785
90Attenuation of retinal blood vessels (HP:0007843)2.28844935
91Short 5th finger (HP:0009237)2.26040533
92Abnormality of the astrocytes (HP:0100707)2.24936877
93Astrocytoma (HP:0009592)2.24936877
94Methylmalonic acidemia (HP:0002912)2.22627952
95Trismus (HP:0000211)2.21000054
96Hyperinsulinemic hypoglycemia (HP:0000825)2.20683516
97Astigmatism (HP:0000483)2.19831718
98Horizontal nystagmus (HP:0000666)2.19736314
99Abnormality of DNA repair (HP:0003254)2.19131163
100Abnormality of small intestinal villus morphology (HP:0011472)2.18043327
101Villous atrophy (HP:0011473)2.18043327
102Amyotrophic lateral sclerosis (HP:0007354)2.17900062
103Premature ovarian failure (HP:0008209)2.17462686
104Abnormal number of erythroid precursors (HP:0012131)2.17142096
105Type I transferrin isoform profile (HP:0003642)2.15798783
106Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15508901
107Dicarboxylic aciduria (HP:0003215)2.15508901
108Tongue fasciculations (HP:0001308)2.14140764
109Methylmalonic aciduria (HP:0012120)2.14016059
110Myelodysplasia (HP:0002863)2.13431799
111Sloping forehead (HP:0000340)2.12675849
112Duplication of thumb phalanx (HP:0009942)2.12489404
113Microretrognathia (HP:0000308)2.11978012
114Abnormal mitochondria in muscle tissue (HP:0008316)2.10803368
115Pigmentary retinal degeneration (HP:0001146)2.09484277
116Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.08290965
117Abnormality of the renal medulla (HP:0100957)2.08193679
118Cheilitis (HP:0100825)2.08092622
119Embryonal neoplasm (HP:0002898)2.06896722
120Lipid accumulation in hepatocytes (HP:0006561)2.06034280
121Abnormality of the lacrimal duct (HP:0011481)2.06002486
122Abnormality of the duodenum (HP:0002246)2.05875136
123Medulloblastoma (HP:0002885)2.05502166
124Flat capital femoral epiphysis (HP:0003370)2.03606756
125Abnormal biliary tract physiology (HP:0012439)2.02490559
126Bile duct proliferation (HP:0001408)2.02490559
127Combined immunodeficiency (HP:0005387)2.01939717
128Facial cleft (HP:0002006)2.01197236
129Absent speech (HP:0001344)2.01193071
130Increased serum lactate (HP:0002151)2.00719325
131Male pseudohermaphroditism (HP:0000037)1.98662795
132Abnormal cartilage morphology (HP:0002763)1.97950122
133Progressive microcephaly (HP:0000253)1.97790703
134Abnormality of alanine metabolism (HP:0010916)1.97378109
135Hyperalaninemia (HP:0003348)1.97378109
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97378109
137Retinitis pigmentosa (HP:0000510)1.96495572
138Albinism (HP:0001022)1.96180471
139Upper motor neuron abnormality (HP:0002127)1.94955137
140Poor head control (HP:0002421)1.94528085
141Ragged-red muscle fibers (HP:0003200)1.93944520
142Skin tags (HP:0010609)1.91429539
143Abnormality of the pubic bones (HP:0003172)1.89899624
144Hyperventilation (HP:0002883)1.89660682
145Vaginal atresia (HP:0000148)1.88788005
146Postaxial foot polydactyly (HP:0001830)1.88404243
147Hypoplastic scapulae (HP:0000882)1.86920881
148Aplasia/Hypoplasia of the scapulae (HP:0006713)1.86920881
149Increased hepatocellular lipid droplets (HP:0006565)1.86641617
150Birth length less than 3rd percentile (HP:0003561)1.84450139
151Genital tract atresia (HP:0001827)1.83588596
152Scrotal hypoplasia (HP:0000046)1.83548224
153Progressive macrocephaly (HP:0004481)1.82962144
154Aganglionic megacolon (HP:0002251)1.82573289
155Sensory axonal neuropathy (HP:0003390)1.82418860
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81757249
157Papillary thyroid carcinoma (HP:0002895)1.81704401
158Atresia of the external auditory canal (HP:0000413)1.81488598
159Bone marrow hypocellularity (HP:0005528)1.81357318
160Muscle fibrillation (HP:0010546)1.80500891
161Scotoma (HP:0000575)1.80117125
162Hypopigmentation of the fundus (HP:0007894)1.79828178
163Clubbing of toes (HP:0100760)1.79406120
164Lactic acidosis (HP:0003128)1.78870916
165Abnormality of male internal genitalia (HP:0000022)1.78759703
166Orchitis (HP:0100796)1.78046710
167Cerebral edema (HP:0002181)1.77720023
168Malignant neoplasm of the central nervous system (HP:0100836)1.77373582
169Gonadal dysgenesis (HP:0000133)1.77252020
170Poor coordination (HP:0002370)1.76541224
171Absent thumb (HP:0009777)1.76400733
172Increased corneal curvature (HP:0100692)1.74249116
173Keratoconus (HP:0000563)1.74249116
174Bony spicule pigmentary retinopathy (HP:0007737)1.74105695
175Urinary bladder sphincter dysfunction (HP:0002839)1.73990446
176Hemiparesis (HP:0001269)1.73631069
177Confusion (HP:0001289)1.73304099
178Sclerocornea (HP:0000647)1.71957883
179Abolished electroretinogram (ERG) (HP:0000550)1.71901571
180Glycosuria (HP:0003076)1.71543804
181Abnormality of urine glucose concentration (HP:0011016)1.71543804
182Aplasia/Hypoplasia of the earlobes (HP:0009906)1.71298305
183Lethargy (HP:0001254)1.69553730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.60912845
2GRK54.91919155
3MAP4K24.84050306
4FRK4.52903192
5VRK24.25979105
6ERN13.62465462
7GRK63.58610704
8ADRBK23.48828537
9GRK13.27936436
10TTK3.19708628
11STK163.13676849
12MOS2.95581313
13BCKDK2.88500147
14CDK192.83541473
15NUAK12.74391086
16CSF1R2.52817399
17MAP3K42.35498938
18GRK72.32602096
19LATS22.32317206
20STK102.21298500
21MAPK72.20752304
22TGFBR22.20662578
23TYRO32.19399693
24WNK31.91317371
25CASK1.88311184
26MATK1.85227056
27OXSR11.82027662
28MST41.79348271
29LATS11.78575414
30TNK21.72937416
31MAP2K71.71667622
32FLT31.64817887
33CDK71.62124488
34STK38L1.61140927
35VRK11.58634551
36CHEK21.57928106
37PLK11.48249705
38CDC71.46954327
39CSNK1G21.46537292
40BMPR1B1.39348751
41AKT31.38111749
42INSRR1.30271230
43CSNK1G31.30152240
44BMPR21.29269951
45PLK41.27985732
46DAPK21.27086667
47WNK11.25860908
48WNK41.21650562
49PDK21.19241940
50TLK11.17433198
51CDK81.16843947
52CSNK1G11.13738987
53TAF11.12574788
54STK391.10804331
55EPHA21.10156369
56TRIM281.09369439
57CSNK1A1L1.08459947
58CAMK41.07075462
59PRKG21.04852372
60KIT1.04229979
61EIF2AK21.04040702
62ADRBK11.03723356
63MARK21.03473206
64ERBB41.00987285
65PINK10.98971173
66HIPK20.98587405
67STK30.97356660
68KDR0.96712941
69MAP3K60.94817936
70MAP2K40.92362393
71PTK2B0.87736460
72EPHA40.86574922
73NEK20.86478873
74PAK40.84921724
75FGFR30.82253312
76NTRK10.77669349
77CHEK10.76951877
78DYRK20.74301394
79ABL20.73797567
80PRKD30.71281835
81MAP2K60.70231774
82SRPK10.63795150
83CAMKK20.61306389
84MAPKAPK50.59111251
85TAOK10.59101699
86AURKB0.58924350
87ERBB30.58442238
88PNCK0.58222903
89DAPK10.57828855
90TAOK30.57636184
91PAK30.55879900
92CAMK1D0.54964617
93CHUK0.54270378
94IKBKB0.54063017
95TXK0.53154387
96MARK10.51545430
97ATM0.50018233
98BCR0.49910746
99PKN10.48764898
100AURKA0.47632061
101PLK20.46952273
102AKT20.45756939
103CSNK1A10.43551558
104PRPF4B0.43132570
105RPS6KA60.42980662
106CDK20.42889256
107TAOK20.42113748
108MUSK0.42073454
109PRKCI0.42034366
110PRKCG0.41666780
111BUB10.40224958
112CSK0.40213639
113CAMK1G0.38662651
114PRKACA0.38405489
115ACVR1B0.38016847
116MAPK120.37820157
117STK380.37759984
118IGF1R0.37166573
119MELK0.36314397
120BRAF0.35412986
121CDK40.35003944
122ATR0.34825957
123RPS6KA50.34532520
124WEE10.33536958
125PRKD20.32484511
126PRKCE0.30776874
127DYRK1A0.30544800
128MARK30.29753168
129CDK10.28491369
130MAP2K20.28386823
131PRKCD0.27266402
132MAP3K110.26257897
133RPS6KB20.25866857
134BRSK10.25653513
135PRKAA10.25421539
136YES10.24417411
137FER0.24235205
138CSNK2A10.24194270
139ZAK0.24130685
140CAMK10.24099414
141CSNK1D0.23936847
142IRAK20.22606396
143TIE10.22576600
144PIM20.22520302
145MAPK130.22238087
146PLK30.21943297
147MAPK10.21467269
148RPS6KA40.21330845
149MKNK20.21119667
150DYRK30.20690525
151MAPKAPK30.20576378
152STK240.20184609
153BRSK20.19684639
154PAK10.19373765
155SIK30.18696974
156GSK3B0.18293405
157MAPK140.18166950
158STK40.17912558
159ERBB20.17655431
160AKT10.16733927
161ABL10.15785193
162MAPK100.15740067
163CDK30.15657558
164ITK0.15289055
165MTOR0.15212965
166PIM10.14962889
167MAP3K100.14103182

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.71743746
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.77499327
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94906850
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.96148321
5Arachidonic acid metabolism_Homo sapiens_hsa005902.71237664
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.59786905
7Linoleic acid metabolism_Homo sapiens_hsa005912.58971292
8Fanconi anemia pathway_Homo sapiens_hsa034602.54222764
9Fructose and mannose metabolism_Homo sapiens_hsa000512.53862932
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49211285
11Cell cycle_Homo sapiens_hsa041102.41055112
12Propanoate metabolism_Homo sapiens_hsa006402.23030480
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17542010
14RNA degradation_Homo sapiens_hsa030182.16878921
15Homologous recombination_Homo sapiens_hsa034402.15837692
16Basal transcription factors_Homo sapiens_hsa030222.15458277
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09308548
18Tryptophan metabolism_Homo sapiens_hsa003802.00525717
19RNA transport_Homo sapiens_hsa030131.95097106
20Ovarian steroidogenesis_Homo sapiens_hsa049131.89430060
21Phototransduction_Homo sapiens_hsa047441.87091727
22Butanoate metabolism_Homo sapiens_hsa006501.85967098
23Oxidative phosphorylation_Homo sapiens_hsa001901.84079310
24Galactose metabolism_Homo sapiens_hsa000521.80661515
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.72447447
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64421793
27DNA replication_Homo sapiens_hsa030301.59839781
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57800771
29Peroxisome_Homo sapiens_hsa041461.57346715
30Caffeine metabolism_Homo sapiens_hsa002321.56851370
31mRNA surveillance pathway_Homo sapiens_hsa030151.54784433
32RNA polymerase_Homo sapiens_hsa030201.54731693
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54185040
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53942260
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.50155907
36Glutathione metabolism_Homo sapiens_hsa004801.46647163
37Ether lipid metabolism_Homo sapiens_hsa005651.45693421
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44418064
39Mismatch repair_Homo sapiens_hsa034301.43348460
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42586435
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.41955871
42Thyroid cancer_Homo sapiens_hsa052161.41584172
43p53 signaling pathway_Homo sapiens_hsa041151.41132348
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39100113
45beta-Alanine metabolism_Homo sapiens_hsa004101.37928215
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36836607
47One carbon pool by folate_Homo sapiens_hsa006701.35373958
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33517624
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31318403
50Parkinsons disease_Homo sapiens_hsa050121.29944403
51Base excision repair_Homo sapiens_hsa034101.29155901
52Nicotine addiction_Homo sapiens_hsa050331.24283995
53Lysine degradation_Homo sapiens_hsa003101.22243016
54Sulfur metabolism_Homo sapiens_hsa009201.20449145
55Herpes simplex infection_Homo sapiens_hsa051681.17467393
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14498100
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11043738
58Pyruvate metabolism_Homo sapiens_hsa006201.10763965
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09362081
60Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09321837
61Olfactory transduction_Homo sapiens_hsa047401.09033193
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08491215
63Protein export_Homo sapiens_hsa030601.05811207
64Non-homologous end-joining_Homo sapiens_hsa034501.05676521
65mTOR signaling pathway_Homo sapiens_hsa041501.04470509
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.01813422
67Other glycan degradation_Homo sapiens_hsa005111.01626107
68Huntingtons disease_Homo sapiens_hsa050160.97101937
69Nitrogen metabolism_Homo sapiens_hsa009100.96523481
70Fatty acid degradation_Homo sapiens_hsa000710.95992797
71Selenocompound metabolism_Homo sapiens_hsa004500.92940564
72Metabolic pathways_Homo sapiens_hsa011000.92552489
73Inositol phosphate metabolism_Homo sapiens_hsa005620.92501428
74MicroRNAs in cancer_Homo sapiens_hsa052060.92434196
75Regulation of autophagy_Homo sapiens_hsa041400.90182514
76Fatty acid elongation_Homo sapiens_hsa000620.89838273
77Taste transduction_Homo sapiens_hsa047420.87765127
78Fat digestion and absorption_Homo sapiens_hsa049750.86881693
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.85243876
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84914575
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84529767
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.84457190
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84095414
84Tyrosine metabolism_Homo sapiens_hsa003500.84004900
85Alzheimers disease_Homo sapiens_hsa050100.81480206
86Nucleotide excision repair_Homo sapiens_hsa034200.80226474
87Basal cell carcinoma_Homo sapiens_hsa052170.78630992
88Folate biosynthesis_Homo sapiens_hsa007900.78253753
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75794909
90ABC transporters_Homo sapiens_hsa020100.75042253
91Pancreatic cancer_Homo sapiens_hsa052120.74413726
92Pyrimidine metabolism_Homo sapiens_hsa002400.74396373
93Choline metabolism in cancer_Homo sapiens_hsa052310.74171386
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73831249
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.71321410
96Influenza A_Homo sapiens_hsa051640.70474346
97Cardiac muscle contraction_Homo sapiens_hsa042600.69251296
98Pathways in cancer_Homo sapiens_hsa052000.68999919
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.68766597
100Proteasome_Homo sapiens_hsa030500.67481678
101Notch signaling pathway_Homo sapiens_hsa043300.67262873
102Hedgehog signaling pathway_Homo sapiens_hsa043400.64077417
103Histidine metabolism_Homo sapiens_hsa003400.64052648
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.63610980
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62452799
106Collecting duct acid secretion_Homo sapiens_hsa049660.61923070
107Hippo signaling pathway_Homo sapiens_hsa043900.61820892
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.61350527
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61183210
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59217371
111African trypanosomiasis_Homo sapiens_hsa051430.58807159
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58015795
113TGF-beta signaling pathway_Homo sapiens_hsa043500.57717431
114Chemical carcinogenesis_Homo sapiens_hsa052040.55109408
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55070797
116Spliceosome_Homo sapiens_hsa030400.53035730
117Adherens junction_Homo sapiens_hsa045200.52470843
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50887919
119Apoptosis_Homo sapiens_hsa042100.48001832
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47309089
121Ribosome_Homo sapiens_hsa030100.47092794
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46708358
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44613655
124Glycerolipid metabolism_Homo sapiens_hsa005610.43555446
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41732971
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.41296304
127Calcium signaling pathway_Homo sapiens_hsa040200.40593438
128Morphine addiction_Homo sapiens_hsa050320.40532604
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40361433
130Retinol metabolism_Homo sapiens_hsa008300.39730153
131Rap1 signaling pathway_Homo sapiens_hsa040150.39675721
132Fatty acid metabolism_Homo sapiens_hsa012120.39411470
133Acute myeloid leukemia_Homo sapiens_hsa052210.39016944
134Ras signaling pathway_Homo sapiens_hsa040140.38959974
135Oocyte meiosis_Homo sapiens_hsa041140.38729438
136HTLV-I infection_Homo sapiens_hsa051660.38396559
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38281143
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38092327
139Pentose phosphate pathway_Homo sapiens_hsa000300.38011886
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36432137
141Small cell lung cancer_Homo sapiens_hsa052220.36431930
142Legionellosis_Homo sapiens_hsa051340.36345937
143Colorectal cancer_Homo sapiens_hsa052100.36175712
144Fatty acid biosynthesis_Homo sapiens_hsa000610.35732461
145Wnt signaling pathway_Homo sapiens_hsa043100.35276141
146N-Glycan biosynthesis_Homo sapiens_hsa005100.35170692
147GABAergic synapse_Homo sapiens_hsa047270.35088691
148Bladder cancer_Homo sapiens_hsa052190.34336549
149Circadian rhythm_Homo sapiens_hsa047100.34052192
150Sphingolipid metabolism_Homo sapiens_hsa006000.33838779
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33630484
152Non-small cell lung cancer_Homo sapiens_hsa052230.33277560
153Arginine and proline metabolism_Homo sapiens_hsa003300.32688581
154Graft-versus-host disease_Homo sapiens_hsa053320.32509499
155Leishmaniasis_Homo sapiens_hsa051400.32274312
156Insulin secretion_Homo sapiens_hsa049110.31957238
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30671956
158Vitamin digestion and absorption_Homo sapiens_hsa049770.30621581
159Purine metabolism_Homo sapiens_hsa002300.30453880
160Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27952649
161Phenylalanine metabolism_Homo sapiens_hsa003600.26363679
162GnRH signaling pathway_Homo sapiens_hsa049120.24736399
163Hematopoietic cell lineage_Homo sapiens_hsa046400.23058213
164Serotonergic synapse_Homo sapiens_hsa047260.21993441
165Hepatitis C_Homo sapiens_hsa051600.21422212
166TNF signaling pathway_Homo sapiens_hsa046680.21205119
167Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20633517
168Sphingolipid signaling pathway_Homo sapiens_hsa040710.20539094

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