MEST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell proliferation involved in metanephros development (GO:0072203)5.45032377
2paraxial mesoderm development (GO:0048339)4.56188684
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.40995846
4mesenchymal cell proliferation (GO:0010463)4.37535329
5glomerular filtration (GO:0003094)4.37473103
6cell proliferation involved in kidney development (GO:0072111)4.34336010
7axon extension involved in axon guidance (GO:0048846)4.33179819
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.33179819
9embryonic foregut morphogenesis (GO:0048617)4.25963856
10artery development (GO:0060840)4.15613397
11G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.11521876
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.08741610
13renal filtration (GO:0097205)3.94852404
14endothelium development (GO:0003158)3.87130288
15hippo signaling (GO:0035329)3.78682438
16establishment of integrated proviral latency (GO:0075713)3.78593454
17DNA unwinding involved in DNA replication (GO:0006268)3.76561572
18pre-miRNA processing (GO:0031054)3.64988885
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.63978599
20chromatin remodeling at centromere (GO:0031055)3.59674027
21positive regulation of vasculogenesis (GO:2001214)3.56896254
22organ formation (GO:0048645)3.55984544
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.55337240
24lymph vessel development (GO:0001945)3.47459775
25basement membrane organization (GO:0071711)3.44377949
26CENP-A containing nucleosome assembly (GO:0034080)3.43010305
27notochord development (GO:0030903)3.41190215
28vasculogenesis (GO:0001570)3.40350275
29mesenchyme morphogenesis (GO:0072132)3.40308142
30outer ear morphogenesis (GO:0042473)3.36691820
31negative regulation of vascular permeability (GO:0043116)3.26205566
32lung-associated mesenchyme development (GO:0060484)3.24830550
33midgut development (GO:0007494)3.23041804
34endocardial cushion morphogenesis (GO:0003203)3.21279398
35convergent extension (GO:0060026)3.18766189
36positive regulation of BMP signaling pathway (GO:0030513)3.16154223
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.15806453
38hindlimb morphogenesis (GO:0035137)3.13557799
39branching involved in salivary gland morphogenesis (GO:0060445)3.13545929
40DNA ligation (GO:0006266)3.12684030
41regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.08572682
42renal system development (GO:0072001)3.08098490
43regulation of mesoderm development (GO:2000380)3.06973928
44lateral sprouting from an epithelium (GO:0060601)3.05738180
45embryonic hindlimb morphogenesis (GO:0035116)3.05403081
46regulation of mesenchymal cell apoptotic process (GO:2001053)3.02372736
47establishment of tissue polarity (GO:0007164)3.01926621
48establishment of planar polarity (GO:0001736)3.01926621
49epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.99307932
50regulation of vasculogenesis (GO:2001212)2.98693332
51endothelial tube morphogenesis (GO:0061154)2.96552649
52morphogenesis of an endothelium (GO:0003159)2.96552649
53histone exchange (GO:0043486)2.95904654
54regulation of organ formation (GO:0003156)2.94266023
55cell migration involved in heart development (GO:0060973)2.92166634
56regulation of sister chromatid cohesion (GO:0007063)2.91659524
57bone trabecula formation (GO:0060346)2.91314978
58somite development (GO:0061053)2.91089441
59negative regulation of axon guidance (GO:1902668)2.89517864
60kinetochore organization (GO:0051383)2.88283724
61negative regulation of embryonic development (GO:0045992)2.88117460
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87851565
63chondrocyte development (GO:0002063)2.87254772
64cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85961013
65negative regulation of axon extension involved in axon guidance (GO:0048843)2.85638986
66embryonic skeletal joint morphogenesis (GO:0060272)2.85231194
67regulation of stem cell maintenance (GO:2000036)2.84155026
68lymphangiogenesis (GO:0001946)2.83700545
69body morphogenesis (GO:0010171)2.82709531
70establishment of apical/basal cell polarity (GO:0035089)2.81038562
71lung epithelium development (GO:0060428)2.80178415
72lung lobe morphogenesis (GO:0060463)2.79777455
73exocrine pancreas development (GO:0031017)2.79627733
74glomerular basement membrane development (GO:0032836)2.79333775
75mesenchyme development (GO:0060485)2.77657762
76regulation of heart morphogenesis (GO:2000826)2.77034055
77positive regulation of epithelial to mesenchymal transition (GO:0010718)2.75597854
78establishment of viral latency (GO:0019043)2.74948089
79branching involved in ureteric bud morphogenesis (GO:0001658)2.72848899
80glucocorticoid receptor signaling pathway (GO:0042921)2.72013151
81DNA replication-independent nucleosome assembly (GO:0006336)2.71868020
82DNA replication-independent nucleosome organization (GO:0034724)2.71868020
83cochlea morphogenesis (GO:0090103)2.71719398
84heart valve formation (GO:0003188)2.71327332
85Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67862143
86negative regulation of smooth muscle cell differentiation (GO:0051151)2.67842859
87kinetochore assembly (GO:0051382)2.67181225
88embryonic forelimb morphogenesis (GO:0035115)2.67095374
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.66906732
90regulation of establishment of planar polarity (GO:0090175)2.66781162
91mitotic sister chromatid cohesion (GO:0007064)2.64705435
92negative regulation of cell fate specification (GO:0009996)2.64655792
93positive regulation of hormone biosynthetic process (GO:0046886)2.63696314
94proximal/distal pattern formation (GO:0009954)2.63501884
95mesenchymal to epithelial transition (GO:0060231)2.62325241
96non-canonical Wnt signaling pathway (GO:0035567)2.61079120
97forelimb morphogenesis (GO:0035136)2.60897746
98patterning of blood vessels (GO:0001569)2.58179189
99proteasome assembly (GO:0043248)2.57326009
100negative regulation of chondrocyte differentiation (GO:0032331)2.56550140
101ATP-dependent chromatin remodeling (GO:0043044)2.55880641
102DNA damage response, detection of DNA damage (GO:0042769)2.55229028
103midbrain development (GO:0030901)2.55052032
104positive regulation of cell size (GO:0045793)2.54245008
105primitive streak formation (GO:0090009)2.54143641
106DNA strand elongation involved in DNA replication (GO:0006271)2.53286480
107blood vessel maturation (GO:0001955)2.53205945
108negative regulation of DNA repair (GO:0045738)2.53077885
109limb bud formation (GO:0060174)2.52456725
110metanephros development (GO:0001656)2.51866637
111dorsal/ventral axis specification (GO:0009950)2.51531338
112outflow tract septum morphogenesis (GO:0003148)2.50439053
113regulation of gene silencing by RNA (GO:0060966)2.50225225
114regulation of posttranscriptional gene silencing (GO:0060147)2.50225225
115regulation of gene silencing by miRNA (GO:0060964)2.50225225
116protein localization to kinetochore (GO:0034501)2.49659889
117mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49501643
118regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.49433801
119negative chemotaxis (GO:0050919)2.48953215
120presynaptic membrane assembly (GO:0097105)2.48495008
121negative regulation of RNA splicing (GO:0033119)2.47823115
122heterochromatin organization (GO:0070828)2.47702440
123negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.45593928
124gastrulation with mouth forming second (GO:0001702)2.44847764
125chondrocyte proliferation (GO:0035988)2.44432151
126prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.42023772
127DNA strand elongation (GO:0022616)2.41288492
128purine nucleobase biosynthetic process (GO:0009113)2.39565796
129regulation of cell fate specification (GO:0042659)2.39279192
130nucleosome disassembly (GO:0006337)2.36077546
131protein-DNA complex disassembly (GO:0032986)2.36077546
132anterior/posterior axis specification, embryo (GO:0008595)2.35946424
133double-strand break repair via nonhomologous end joining (GO:0006303)2.34345992
134non-recombinational repair (GO:0000726)2.34345992
135mitotic metaphase plate congression (GO:0007080)2.33903531
136ventricular cardiac muscle cell development (GO:0055015)2.32451024
137metaphase plate congression (GO:0051310)2.32342027
138somatic stem cell division (GO:0048103)2.31225098
139hyperosmotic salinity response (GO:0042538)2.31116576
140IMP biosynthetic process (GO:0006188)2.30557056
141negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.29690684
142regulation of centriole replication (GO:0046599)2.29297156
143digestive tract morphogenesis (GO:0048546)2.29167761
144DNA double-strand break processing (GO:0000729)2.28891249
145female gonad development (GO:0008585)2.27810607
146thalamus development (GO:0021794)2.27430390
147regulation of gastrulation (GO:0010470)2.26497731
148regulation of helicase activity (GO:0051095)2.24873624
149somatic hypermutation of immunoglobulin genes (GO:0016446)2.24560764
150somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24560764
151telomere maintenance via semi-conservative replication (GO:0032201)2.24259032
152ribosomal small subunit assembly (GO:0000028)2.23920568
153negative regulation of DNA recombination (GO:0045910)2.23195147
154generation of neurons (GO:0048699)2.22924016
155urogenital system development (GO:0001655)2.22716221
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.20264812
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.20195261
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.20195261
159negative regulation of mitotic sister chromatid segregation (GO:0033048)2.20195261
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.20195261
161negative regulation of sister chromatid segregation (GO:0033046)2.20195261
162nucleobase biosynthetic process (GO:0046112)2.19384470
163positive regulation of gastrulation (GO:2000543)2.19143450
164spindle checkpoint (GO:0031577)2.18133351
165retinal ganglion cell axon guidance (GO:0031290)2.16104210
166pituitary gland development (GO:0021983)2.16040984
167otic vesicle formation (GO:0030916)2.15828788
168anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.15037070
169mitotic spindle checkpoint (GO:0071174)2.13858027
170negative regulation of cartilage development (GO:0061037)2.12298923
171negative regulation of chromosome segregation (GO:0051985)2.12060587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97659887
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.90506423
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.45124968
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.37965396
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53818959
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.36059520
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98146117
8AR_21909140_ChIP-Seq_LNCAP_Human2.88711514
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82578086
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.53121949
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49231142
12* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.37757480
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32378320
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.22305770
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.06468226
16FUS_26573619_Chip-Seq_HEK293_Human2.06022771
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.03250661
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97418712
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96211658
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93422690
21SOX2_18555785_ChIP-Seq_MESCs_Mouse1.90976566
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90742193
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90231979
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90231979
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90231979
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88019884
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85619521
28EZH2_22144423_ChIP-Seq_EOC_Human1.84225528
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83314239
30* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.83084456
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79919989
32XRN2_22483619_ChIP-Seq_HELA_Human1.78991023
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.78633332
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77733555
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76612625
36* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75912558
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72571606
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72329219
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71870372
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71340240
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.70153657
42ELK1_19687146_ChIP-ChIP_HELA_Human1.65008267
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64423235
44GBX2_23144817_ChIP-Seq_PC3_Human1.63693254
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63019511
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62323808
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.59225237
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.56731491
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52050276
50CLOCK_20551151_ChIP-Seq_293T_Human1.48147501
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.45428437
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44029928
53P300_19829295_ChIP-Seq_ESCs_Human1.43552329
54* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42294656
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.41871866
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.38843809
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38671814
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.37143701
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36979802
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36462197
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36300464
62TTF2_22483619_ChIP-Seq_HELA_Human1.35552695
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33719979
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33512784
65* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33201108
66TAF15_26573619_Chip-Seq_HEK293_Human1.33121708
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31559618
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.30694968
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29253484
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.26595735
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24983022
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.24410182
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24296241
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23245969
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23167222
76IGF1R_20145208_ChIP-Seq_DFB_Human1.22465080
77* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22104712
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21793002
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21400697
80* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.20707278
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20228736
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17845700
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15407699
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15086542
85ZNF274_21170338_ChIP-Seq_K562_Hela1.14814933
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14027936
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12853443
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.10473953
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10470184
90BRD4_25478319_ChIP-Seq_HGPS_Human1.10348740
91MYC_22102868_ChIP-Seq_BL_Human1.09983943
92CIITA_25753668_ChIP-Seq_RAJI_Human1.09905162
93* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08395029
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08184517
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.07322958
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07000014
97MYC_18940864_ChIP-ChIP_HL60_Human1.06582274
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06284571
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.06109880
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05976702
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04785636
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.04642337
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03574267
104EWS_26573619_Chip-Seq_HEK293_Human1.02899448
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02816376
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.02480281
107RNF2_27304074_Chip-Seq_NSC_Mouse1.02385865
108SOX9_26525672_Chip-Seq_HEART_Mouse1.02077551
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01928028
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.01900133
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01745651
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01119383
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00704518
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00444612
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99582630
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99367641
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99257701
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99099918
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.98811740
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97424097
121EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97039379
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97039379
123* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95671646
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.95003606
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93785156
126TRIM28_21343339_ChIP-Seq_HEK293_Human0.93395397
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93366769
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.93196647
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92424787
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91723626
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91707385
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91651631
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89636612
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89611018
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89219096
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88725427
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87419506
138HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87360350
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86737281
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85094978
141CHD1_26751641_Chip-Seq_LNCaP_Human0.84880663
142RNF2_27304074_Chip-Seq_ESCs_Mouse0.84093441
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83963008
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82436868
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82128246
146EST1_17652178_ChIP-ChIP_JURKAT_Human0.81453842
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80201785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003122_maternal_imprinting4.12653354
2MP0003123_paternal_imprinting3.78726416
3MP0010368_abnormal_lymphatic_system3.73237949
4MP0010030_abnormal_orbit_morphology3.61706491
5MP0009053_abnormal_anal_canal3.34422371
6MP0000537_abnormal_urethra_morphology3.25391854
7MP0004272_abnormal_basement_membrane2.95273767
8MP0001879_abnormal_lymphatic_vessel2.86755613
9* MP0003121_genomic_imprinting2.60387646
10MP0003385_abnormal_body_wall2.40439565
11MP0003283_abnormal_digestive_organ2.35333851
12MP0006292_abnormal_olfactory_placode2.33087393
13MP0005167_abnormal_blood-brain_barrier2.26549022
14MP0003942_abnormal_urinary_system2.26393802
15MP0003705_abnormal_hypodermis_morpholog2.11296182
16MP0000566_synostosis2.02526898
17MP0002249_abnormal_larynx_morphology1.98048842
18MP0003567_abnormal_fetal_cardiomyocyte1.96925524
19MP0002282_abnormal_trachea_morphology1.93211693
20MP0005275_abnormal_skin_tensile1.92689581
21MP0003937_abnormal_limbs/digits/tail_de1.84326972
22MP0002932_abnormal_joint_morphology1.83270592
23MP0001293_anophthalmia1.77775181
24MP0002938_white_spotting1.75479879
25MP0000049_abnormal_middle_ear1.74226172
26MP0003119_abnormal_digestive_system1.73274455
27MP0003115_abnormal_respiratory_system1.71130367
28MP0000534_abnormal_ureter_morphology1.69114637
29MP0005503_abnormal_tendon_morphology1.68599642
30MP0009250_abnormal_appendicular_skeleto1.67210692
31MP0006054_spinal_hemorrhage1.64454856
32MP0003315_abnormal_perineum_morphology1.61488384
33MP0008789_abnormal_olfactory_epithelium1.56556032
34MP0004133_heterotaxia1.56099755
35MP0004084_abnormal_cardiac_muscle1.53092854
36MP0001299_abnormal_eye_distance/1.51071658
37MP0001529_abnormal_vocalization1.50990438
38MP0003935_abnormal_craniofacial_develop1.45011407
39MP0000428_abnormal_craniofacial_morphol1.43575691
40MP0000767_abnormal_smooth_muscle1.43157818
41MP0008058_abnormal_DNA_repair1.41061140
42MP0000778_abnormal_nervous_system1.40417779
43MP0002234_abnormal_pharynx_morphology1.39926557
44MP0002085_abnormal_embryonic_tissue1.39051775
45* MP0004197_abnormal_fetal_growth/weight/1.36982702
46MP0003077_abnormal_cell_cycle1.36032911
47MP0004233_abnormal_muscle_weight1.35016621
48MP0005248_abnormal_Harderian_gland1.34741872
49MP0003984_embryonic_growth_retardation1.33238580
50MP0003718_maternal_effect1.32666304
51MP0003136_yellow_coat_color1.32090580
52MP0002088_abnormal_embryonic_growth/wei1.30733719
53MP0002084_abnormal_developmental_patter1.30328748
54MP0003755_abnormal_palate_morphology1.29742757
55MP0001672_abnormal_embryogenesis/_devel1.29688489
56MP0005380_embryogenesis_phenotype1.29688489
57MP0006138_congestive_heart_failure1.27450422
58MP0000631_abnormal_neuroendocrine_gland1.27353271
59MP0009697_abnormal_copulation1.27185007
60MP0005499_abnormal_olfactory_system1.26687332
61MP0005394_taste/olfaction_phenotype1.26687332
62MP0003111_abnormal_nucleus_morphology1.25946027
63MP0010094_abnormal_chromosome_stability1.25286394
64MP0005623_abnormal_meninges_morphology1.24948900
65MP0002925_abnormal_cardiovascular_devel1.24035309
66MP0008932_abnormal_embryonic_tissue1.23841241
67MP0001177_atelectasis1.23801330
68MP0005076_abnormal_cell_differentiation1.23548709
69MP0002233_abnormal_nose_morphology1.21978460
70MP0003938_abnormal_ear_development1.21134960
71MP0000579_abnormal_nail_morphology1.17489971
72MP0008057_abnormal_DNA_replication1.17291080
73* MP0001697_abnormal_embryo_size1.15860310
74MP0000462_abnormal_digestive_system1.15194660
75MP0002116_abnormal_craniofacial_bone1.13688743
76MP0004957_abnormal_blastocyst_morpholog1.13254505
77MP0006276_abnormal_autonomic_nervous1.12694352
78MP0008007_abnormal_cellular_replicative1.12389268
79MP0006072_abnormal_retinal_apoptosis1.12147052
80MP0000733_abnormal_muscle_development1.11796861
81MP0001730_embryonic_growth_arrest1.11180382
82MP0002109_abnormal_limb_morphology1.09509971
83* MP0002086_abnormal_extraembryonic_tissu1.08525880
84MP0002092_abnormal_eye_morphology1.08464553
85MP0002111_abnormal_tail_morphology1.08309589
86MP0005391_vision/eye_phenotype1.06617483
87MP0003828_pulmonary_edema1.06147549
88MP0002102_abnormal_ear_morphology1.05738928
89MP0003279_aneurysm1.05027474
90MP0009379_abnormal_foot_pigmentation1.04948703
91MP0002697_abnormal_eye_size1.04627869
92MP0002108_abnormal_muscle_morphology1.04479861
93MP0009672_abnormal_birth_weight1.02674273
94MP0002127_abnormal_cardiovascular_syste1.02579362
95MP0005367_renal/urinary_system_phenotyp1.00701601
96MP0000516_abnormal_urinary_system1.00701601
97MP0003693_abnormal_embryo_hatching1.00551490
98MP0008438_abnormal_cutaneous_collagen1.00274982
99MP0008877_abnormal_DNA_methylation1.00194645
100MP0001286_abnormal_eye_development1.00053143
101MP0005508_abnormal_skeleton_morphology0.99210975
102MP0003943_abnormal_hepatobiliary_system0.99001638
103MP0002822_catalepsy0.98619147
104MP0000350_abnormal_cell_proliferation0.98034791
105MP0005187_abnormal_penis_morphology0.97180552
106MP0004264_abnormal_extraembryonic_tissu0.96685048
107* MP0000266_abnormal_heart_morphology0.96224503
108MP0005377_hearing/vestibular/ear_phenot0.95843660
109MP0003878_abnormal_ear_physiology0.95843660
110MP0002751_abnormal_autonomic_nervous0.94886279
111MP0000383_abnormal_hair_follicle0.94567995
112MP0009703_decreased_birth_body0.94469817
113MP0001915_intracranial_hemorrhage0.92782526
114MP0002114_abnormal_axial_skeleton0.90535752
115MP0000163_abnormal_cartilage_morphology0.90204465
116MP0000762_abnormal_tongue_morphology0.89210143
117MP0000432_abnormal_head_morphology0.89200622
118MP0003861_abnormal_nervous_system0.88289171
119MP0001614_abnormal_blood_vessel0.88022541
120* MP0010630_abnormal_cardiac_muscle0.87694451
121MP0002653_abnormal_ependyma_morphology0.86049068
122MP0002080_prenatal_lethality0.85779852
123MP0002128_abnormal_blood_circulation0.85152848
124MP0003890_abnormal_embryonic-extraembry0.84618619
125MP0001346_abnormal_lacrimal_gland0.84155542
126* MP0002081_perinatal_lethality0.82071702
127MP0001188_hyperpigmentation0.80494531
128MP0003941_abnormal_skin_development0.80207707
129MP0000026_abnormal_inner_ear0.78203952
130MP0002184_abnormal_innervation0.76516805

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.19243181
2Short 4th metacarpal (HP:0010044)5.19243181
3Asymmetry of the thorax (HP:0001555)4.10969197
4Abnormality of the 4th metacarpal (HP:0010012)4.00245127
5Renal duplication (HP:0000075)3.75208401
6Hepatoblastoma (HP:0002884)3.48554154
7Diastasis recti (HP:0001540)3.48377909
8Protrusio acetabuli (HP:0003179)3.47887887
9Abnormality of the labia minora (HP:0012880)3.31470491
10Abnormal number of incisors (HP:0011064)3.26971668
11Nephroblastoma (Wilms tumor) (HP:0002667)3.11259980
12Septo-optic dysplasia (HP:0100842)3.06119739
13Bilateral microphthalmos (HP:0007633)2.99813833
14Embryonal renal neoplasm (HP:0011794)2.96905960
15Shallow orbits (HP:0000586)2.88653261
16Skull defect (HP:0001362)2.72527287
17Anophthalmia (HP:0000528)2.72402196
18Lymphangioma (HP:0100764)2.69517683
19Short 5th finger (HP:0009237)2.60738012
20Midline defect of the nose (HP:0004122)2.54370690
21Premature rupture of membranes (HP:0001788)2.54211236
22Broad toe (HP:0001837)2.52113648
23Abnormal lung lobation (HP:0002101)2.51780733
24Broad thumb (HP:0011304)2.47871439
25Spinal cord lesions (HP:0100561)2.43587998
26Syringomyelia (HP:0003396)2.43587998
27Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.38161653
28Broad phalanges of the hand (HP:0009768)2.31180099
29Trigonocephaly (HP:0000243)2.31166731
30Neonatal short-limb short stature (HP:0008921)2.26804581
31Abnormal pancreas size (HP:0012094)2.25804905
32Broad finger (HP:0001500)2.23315801
33Atresia of the external auditory canal (HP:0000413)2.20598426
34Calcaneovalgus deformity (HP:0001848)2.18031542
35Preaxial foot polydactyly (HP:0001841)2.17397350
36Choanal stenosis (HP:0000452)2.16298132
37Increased nuchal translucency (HP:0010880)2.13849160
38Distal arthrogryposis (HP:0005684)2.09823445
39Cutaneous finger syndactyly (HP:0010554)2.09439357
40Broad metatarsal (HP:0001783)2.09251525
41Short middle phalanx of the 5th finger (HP:0004220)2.06118821
42Broad phalanx (HP:0006009)2.06029832
43Bifid tongue (HP:0010297)2.04061874
44Myelomeningocele (HP:0002475)2.02338404
45Mesomelia (HP:0003027)2.01231210
46Absent septum pellucidum (HP:0001331)2.00425154
47Abnormality of the aortic arch (HP:0012303)2.00322139
48Deformed tarsal bones (HP:0008119)1.99438540
49Renal hypoplasia (HP:0000089)1.97771370
50Broad long bones (HP:0005622)1.97489249
51Abnormality of the parietal bone (HP:0002696)1.96364655
52Bicuspid aortic valve (HP:0001647)1.95040044
53Abdominal situs inversus (HP:0003363)1.94589654
54Abnormality of abdominal situs (HP:0011620)1.94589654
55Colon cancer (HP:0003003)1.93838075
56Abnormality of the phalanges of the hallux (HP:0010057)1.91703660
57Cutaneous syndactyly (HP:0012725)1.91531843
58Facial cleft (HP:0002006)1.88961231
59Esophageal atresia (HP:0002032)1.88395016
60Deviation of the hallux (HP:0010051)1.88048785
61Intestinal polyp (HP:0005266)1.88023861
62Partial duplication of thumb phalanx (HP:0009944)1.87174042
63Breech presentation (HP:0001623)1.86398100
64Broad palm (HP:0001169)1.86007621
65Aortic dissection (HP:0002647)1.85727962
66Bicornuate uterus (HP:0000813)1.84851455
67Stenosis of the external auditory canal (HP:0000402)1.84847843
68Wide anterior fontanel (HP:0000260)1.84768101
69Wrist flexion contracture (HP:0001239)1.83963869
70Vitreoretinal degeneration (HP:0000655)1.83737797
71Intestinal polyposis (HP:0200008)1.83357593
72Reticulocytopenia (HP:0001896)1.83203770
73Microglossia (HP:0000171)1.82550304
74Long eyelashes (HP:0000527)1.82123545
75Selective tooth agenesis (HP:0001592)1.81395498
76Abnormal umbilical cord blood vessels (HP:0011403)1.81326994
77Single umbilical artery (HP:0001195)1.81326994
78Abnormality of the fetal cardiovascular system (HP:0010948)1.81326994
79Abnormality of the septum pellucidum (HP:0007375)1.81001041
80Coronal craniosynostosis (HP:0004440)1.80518246
81Hypoplastic pelvis (HP:0008839)1.80472222
82Triphalangeal thumb (HP:0001199)1.79445201
83Supernumerary ribs (HP:0005815)1.78706309
84Synostosis of carpal bones (HP:0005048)1.78526500
85Aortic aneurysm (HP:0004942)1.78131576
86Optic nerve hypoplasia (HP:0000609)1.78097929
87Carpal synostosis (HP:0009702)1.77908428
88Hyperglycinemia (HP:0002154)1.77145084
89Exostoses (HP:0100777)1.77016252
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76912772
91Overgrowth (HP:0001548)1.76639997
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.75837456
93Spastic diplegia (HP:0001264)1.74910483
94Abnormality of the incisor (HP:0000676)1.74523046
95Cortical dysplasia (HP:0002539)1.73944549
96Supernumerary spleens (HP:0009799)1.73640069
97Abnormality of the calcaneus (HP:0008364)1.73309119
98Meckel diverticulum (HP:0002245)1.72715436
99High anterior hairline (HP:0009890)1.72357423
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70981337
101Aqueductal stenosis (HP:0002410)1.70699882
102Hemivertebrae (HP:0002937)1.70466940
103Pterygium (HP:0001059)1.70018778
104Small intestinal stenosis (HP:0012848)1.69981505
105Duodenal stenosis (HP:0100867)1.69981505
106Fibular hypoplasia (HP:0003038)1.69758493
107Bowel diverticulosis (HP:0005222)1.69567084
108Abnormality of dentin (HP:0010299)1.69113445
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.68595746
110Thin ribs (HP:0000883)1.67841436
111Broad hallux (HP:0010055)1.67683638
112Patellar aplasia (HP:0006443)1.67443976
113Hallux valgus (HP:0001822)1.67285973
114Vertebral clefting (HP:0008428)1.66878350
115Irregular epiphyses (HP:0010582)1.66064746
116Medulloblastoma (HP:0002885)1.65384416
117Wide cranial sutures (HP:0010537)1.65306662
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.65257587
119Bladder diverticulum (HP:0000015)1.65246453
120Deviation of the thumb (HP:0009603)1.64211511
121Ectopic anus (HP:0004397)1.64155395
122Soft skin (HP:0000977)1.63969387
123Supernumerary bones of the axial skeleton (HP:0009144)1.63762368
124Hypoplastic female external genitalia (HP:0012815)1.63691244
125Proximal placement of thumb (HP:0009623)1.63643235
126Aplasia/Hypoplasia of the patella (HP:0006498)1.63340242
127Abnormality of the ischium (HP:0003174)1.63058717
128Abnormal hair whorl (HP:0010721)1.63029459
129Morphological abnormality of the middle ear (HP:0008609)1.62480213
130High pitched voice (HP:0001620)1.62204387
131Buphthalmos (HP:0000557)1.61847326
132Short phalanx of the thumb (HP:0009660)1.61646052
133Broad distal phalanx of finger (HP:0009836)1.61593720
134Vaginal atresia (HP:0000148)1.61388086
135Absent eyebrow (HP:0002223)1.61237168
136Cerebral aneurysm (HP:0004944)1.60972745
137Sprengel anomaly (HP:0000912)1.60712550
138Genital tract atresia (HP:0001827)1.60010009
139Split foot (HP:0001839)1.59404596
140Gastrointestinal atresia (HP:0002589)1.58669903
141Maternal diabetes (HP:0009800)1.58450185
142Omphalocele (HP:0001539)1.58407647
143Duplication of thumb phalanx (HP:0009942)1.58283194
144Hypospadias (HP:0000047)1.58218184
145Abnormality of the ileum (HP:0001549)1.58021747
146Abnormality of the duodenum (HP:0002246)1.57781779
147Abnormality of the radial head (HP:0003995)1.57764100
148Renovascular hypertension (HP:0100817)1.57596807
149Partial duplication of the phalanx of hand (HP:0009999)1.57389348
150Labial hypoplasia (HP:0000066)1.57175201
151Abnormality of the diencephalon (HP:0010662)1.56891409
152Narrow nasal bridge (HP:0000446)1.56798273
153Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56726597
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.55755952
155Vertebral hypoplasia (HP:0008417)1.55755952
156Abnormality of the nasolacrimal system (HP:0000614)1.55277559
157Ependymoma (HP:0002888)1.55221810
158Embryonal neoplasm (HP:0002898)1.55154698
159Intestinal atresia (HP:0011100)1.54988058
160Rib fusion (HP:0000902)1.54506746
161Aplasia involving bones of the extremities (HP:0009825)1.53705024
162Aplasia of the phalanges of the hand (HP:0009802)1.53705024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.28427830
2EPHB23.96142711
3KDR3.55823537
4TGFBR13.02957076
5VRK22.73896331
6CDC72.58286808
7KSR12.57068940
8TNIK2.54504202
9MAP3K102.53247761
10PKN22.52808095
11BUB12.51871967
12PNCK2.36081736
13PBK2.16424439
14SIK32.14254353
15WNK32.09839772
16BCR2.08402877
17LATS12.06169305
18WEE12.01600337
19MKNK11.94773726
20TAF11.84732964
21NEK21.84491203
22PASK1.82406989
23CASK1.70764115
24ZAK1.67836612
25NUAK11.67127342
26PAK41.64618914
27NEK11.64492657
28VRK11.63110109
29FGFR11.61144447
30TRIB31.55683236
31DYRK21.55437099
32LATS21.53907153
33TGFBR21.47063961
34NME11.46302981
35MAP4K21.40245815
36TTK1.38499276
37PTK61.34265483
38SRPK11.30894015
39TRIM281.29613325
40CDK71.29427514
41PLK31.27118543
42PRKD31.27110071
43ERBB21.25796517
44PTK2B1.19511975
45TSSK61.18660892
46TAOK21.15577889
47PLK11.14024970
48INSRR1.13277199
49ERBB31.13013582
50MAP2K31.11311657
51BMPR1B1.11209777
52CDK121.10476230
53PDGFRA1.08889108
54EPHA41.05682869
55DMPK1.05248699
56MAP3K81.04811238
57RPS6KA41.04493502
58BRSK21.03324536
59STK31.00615721
60STK160.99705939
61EIF2AK30.99231697
62PLK40.97513989
63CDK190.93657348
64PTK20.92993644
65ATR0.91364596
66DYRK30.90785926
67MKNK20.90784727
68NEK90.87112662
69CSNK1G20.86112301
70BCKDK0.85760824
71BRD40.85298102
72MAP3K40.85192972
73CHEK20.84034953
74NTRK10.83093839
75UHMK10.81141483
76MTOR0.80292992
77CDK80.77344933
78MET0.76437016
79FER0.75984510
80AURKB0.75429959
81GRK10.75147258
82EIF2AK20.74939764
83DDR20.74720754
84ICK0.74188261
85SIK10.72241893
86MAPK150.71902676
87PLK20.69917313
88FGFR20.69702705
89PAK20.69406680
90CHEK10.68786160
91ILK0.68367467
92AKT20.67471227
93EIF2AK10.65220757
94STK38L0.64244444
95CDK30.62823397
96OBSCN0.62498218
97CAMK1G0.62437664
98CSNK1A1L0.61375117
99MAP3K110.61320176
100MARK10.60892340
101MINK10.60123901
102STK100.55576770
103BRSK10.55258757
104CDK60.52093008
105LRRK20.51135906
106CLK10.51008611
107CDK140.51006902
108LIMK10.50125331
109CDK20.50106994
110AURKA0.50106089
111PRKCG0.49959364
112CDK10.49026574
113RIPK10.48734208
114ATM0.48626900
115ROCK20.47908553
116CDK40.47257719
117MAP2K70.46141482
118CDK180.45962099
119TTN0.45803956
120CSNK1G30.45587794
121NLK0.44880458
122CSNK1E0.44605971
123STK40.44368659
124NTRK20.42230779
125TESK10.42158810
126YES10.41479043
127PRKCE0.41078648
128CDK90.40539069
129ROCK10.40396047
130PRKDC0.40345743
131CSNK1G10.39572279
132CDK11A0.39473057
133SRC0.38287297
134MELK0.37472199
135FLT30.37325512
136MYLK0.36968322
137DYRK1A0.34600569
138AKT10.34485333
139SCYL20.32854492
140TYRO30.32569569
141MAPKAPK50.32220142
142EPHA30.31697268
143CDK150.29768405

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.05636398
2Cell cycle_Homo sapiens_hsa041103.26943920
3Hedgehog signaling pathway_Homo sapiens_hsa043403.19615594
4DNA replication_Homo sapiens_hsa030303.14859518
5Hippo signaling pathway_Homo sapiens_hsa043902.92531267
6Spliceosome_Homo sapiens_hsa030402.54662161
7Mismatch repair_Homo sapiens_hsa034302.34748444
8RNA transport_Homo sapiens_hsa030132.18435538
9Adherens junction_Homo sapiens_hsa045202.04568621
10Base excision repair_Homo sapiens_hsa034102.04169142
11TGF-beta signaling pathway_Homo sapiens_hsa043501.99500984
12mRNA surveillance pathway_Homo sapiens_hsa030151.98230956
13Protein export_Homo sapiens_hsa030601.95827522
14Oocyte meiosis_Homo sapiens_hsa041141.95611834
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.85692151
16Notch signaling pathway_Homo sapiens_hsa043301.85680960
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.84002966
18Wnt signaling pathway_Homo sapiens_hsa043101.79406770
19MicroRNAs in cancer_Homo sapiens_hsa052061.78037950
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72463004
21Propanoate metabolism_Homo sapiens_hsa006401.68914322
22Proteoglycans in cancer_Homo sapiens_hsa052051.67540340
23Melanogenesis_Homo sapiens_hsa049161.57971792
24Fatty acid elongation_Homo sapiens_hsa000621.57952319
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57427796
26HTLV-I infection_Homo sapiens_hsa051661.53236362
27Axon guidance_Homo sapiens_hsa043601.51611637
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51041895
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50860671
30Small cell lung cancer_Homo sapiens_hsa052221.50214614
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48181876
32Focal adhesion_Homo sapiens_hsa045101.47962915
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46936062
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46373255
35ECM-receptor interaction_Homo sapiens_hsa045121.44394049
36Tight junction_Homo sapiens_hsa045301.41826250
37Pyruvate metabolism_Homo sapiens_hsa006201.39638785
38Viral myocarditis_Homo sapiens_hsa054161.39314789
39Parkinsons disease_Homo sapiens_hsa050121.38697145
40Thyroid cancer_Homo sapiens_hsa052161.34321558
41Selenocompound metabolism_Homo sapiens_hsa004501.34038301
42Nucleotide excision repair_Homo sapiens_hsa034201.33173480
43Pathways in cancer_Homo sapiens_hsa052001.31950962
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.31132964
45Homologous recombination_Homo sapiens_hsa034401.27724287
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26378433
47Dilated cardiomyopathy_Homo sapiens_hsa054141.25534476
48Steroid biosynthesis_Homo sapiens_hsa001001.23981912
49Oxidative phosphorylation_Homo sapiens_hsa001901.22816771
50Colorectal cancer_Homo sapiens_hsa052101.22442519
51Chronic myeloid leukemia_Homo sapiens_hsa052201.17860757
52RNA degradation_Homo sapiens_hsa030181.15297030
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12795192
54Huntingtons disease_Homo sapiens_hsa050161.11559554
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11209849
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10250717
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07743067
58p53 signaling pathway_Homo sapiens_hsa041151.03959691
59Prostate cancer_Homo sapiens_hsa052151.02827394
60Bladder cancer_Homo sapiens_hsa052191.01794786
61PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01446319
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00259873
63Rap1 signaling pathway_Homo sapiens_hsa040150.99438685
64Pyrimidine metabolism_Homo sapiens_hsa002400.96815579
65Glutathione metabolism_Homo sapiens_hsa004800.95940188
66Viral carcinogenesis_Homo sapiens_hsa052030.91634912
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91343835
68Endometrial cancer_Homo sapiens_hsa052130.90290892
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.88627999
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86333691
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.85640251
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83782595
73Carbon metabolism_Homo sapiens_hsa012000.81569853
74Fanconi anemia pathway_Homo sapiens_hsa034600.81152244
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80972532
76Epstein-Barr virus infection_Homo sapiens_hsa051690.78170933
77Renal cell carcinoma_Homo sapiens_hsa052110.77791489
78Gap junction_Homo sapiens_hsa045400.77777632
79One carbon pool by folate_Homo sapiens_hsa006700.75533745
80Proteasome_Homo sapiens_hsa030500.73552294
81HIF-1 signaling pathway_Homo sapiens_hsa040660.73066783
82Lysine degradation_Homo sapiens_hsa003100.72439677
83Alzheimers disease_Homo sapiens_hsa050100.72431580
84Pancreatic cancer_Homo sapiens_hsa052120.70868195
85Basal transcription factors_Homo sapiens_hsa030220.70653320
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70350330
87Ribosome_Homo sapiens_hsa030100.68360561
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68090770
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68033085
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.67157932
91Melanoma_Homo sapiens_hsa052180.66501538
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66467794
93Phototransduction_Homo sapiens_hsa047440.65904548
94Shigellosis_Homo sapiens_hsa051310.65310490
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64981177
96N-Glycan biosynthesis_Homo sapiens_hsa005100.64878998
97Protein digestion and absorption_Homo sapiens_hsa049740.63858331
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62891412
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62744226
100Fatty acid metabolism_Homo sapiens_hsa012120.62507783
101Glioma_Homo sapiens_hsa052140.60923390
102RNA polymerase_Homo sapiens_hsa030200.60088970
103Folate biosynthesis_Homo sapiens_hsa007900.58377501
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58208411
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57751259
106Butanoate metabolism_Homo sapiens_hsa006500.57158164
107Non-small cell lung cancer_Homo sapiens_hsa052230.56487957
108Estrogen signaling pathway_Homo sapiens_hsa049150.55633869
109Cocaine addiction_Homo sapiens_hsa050300.54042751
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54029978
111Cardiac muscle contraction_Homo sapiens_hsa042600.53884664
112Alcoholism_Homo sapiens_hsa050340.53303734
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52865749
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51758723
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51122118
116Metabolic pathways_Homo sapiens_hsa011000.49718484
117Hepatitis B_Homo sapiens_hsa051610.49423676
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48742782
119mTOR signaling pathway_Homo sapiens_hsa041500.48656692
120VEGF signaling pathway_Homo sapiens_hsa043700.48561596
121Platelet activation_Homo sapiens_hsa046110.48301831
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47989040
123Purine metabolism_Homo sapiens_hsa002300.46505757
124Nitrogen metabolism_Homo sapiens_hsa009100.45279823
125Herpes simplex infection_Homo sapiens_hsa051680.42654303
126Biosynthesis of amino acids_Homo sapiens_hsa012300.41582051
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41578563
128Peroxisome_Homo sapiens_hsa041460.41074416
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39643034
130Systemic lupus erythematosus_Homo sapiens_hsa053220.39049386
131Non-homologous end-joining_Homo sapiens_hsa034500.38855108
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37924055
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35959529
134Dorso-ventral axis formation_Homo sapiens_hsa043200.35537238
135Vitamin digestion and absorption_Homo sapiens_hsa049770.35510177
136beta-Alanine metabolism_Homo sapiens_hsa004100.35033031
137Tryptophan metabolism_Homo sapiens_hsa003800.33872688
138Fatty acid degradation_Homo sapiens_hsa000710.33812159
139Vitamin B6 metabolism_Homo sapiens_hsa007500.33553520
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.32228836
141AMPK signaling pathway_Homo sapiens_hsa041520.32063935
142Fat digestion and absorption_Homo sapiens_hsa049750.31413084
143Taste transduction_Homo sapiens_hsa047420.31035490
144FoxO signaling pathway_Homo sapiens_hsa040680.30430352

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