MESTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urea cycle (GO:0000050)5.36982853
2positive regulation of p38MAPK cascade (GO:1900745)5.16528007
3cytidine deamination (GO:0009972)4.84326711
4cytidine metabolic process (GO:0046087)4.84326711
5cytidine catabolic process (GO:0006216)4.84326711
6urea metabolic process (GO:0019627)4.83401166
7regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.81827501
8dendritic spine morphogenesis (GO:0060997)4.61062278
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.60328869
10negative regulation of actin filament bundle assembly (GO:0032232)4.58112146
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.46819004
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.43201637
13sarcomere organization (GO:0045214)4.42980063
14cell migration involved in gastrulation (GO:0042074)4.34628351
15nitrogen cycle metabolic process (GO:0071941)4.12174566
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.10136734
17pyrimidine ribonucleoside catabolic process (GO:0046133)4.08988575
18muscle filament sliding (GO:0030049)3.98804301
19actin-myosin filament sliding (GO:0033275)3.98804301
20righting reflex (GO:0060013)3.96268984
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.92547846
22actin-mediated cell contraction (GO:0070252)3.90732070
23tongue development (GO:0043586)3.87131882
24regulation of p38MAPK cascade (GO:1900744)3.85689031
25cardiac muscle hypertrophy (GO:0003300)3.85143784
26response to epinephrine (GO:0071871)3.84162098
27striated muscle hypertrophy (GO:0014897)3.80821644
28somite rostral/caudal axis specification (GO:0032525)3.72662979
29regulation of skeletal muscle contraction (GO:0014819)3.68209214
30cardiac muscle tissue morphogenesis (GO:0055008)3.68031900
31retina vasculature morphogenesis in camera-type eye (GO:0061299)3.65715810
32cardiac muscle cell development (GO:0055013)3.60493258
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.57271643
34organ growth (GO:0035265)3.56992235
35cardiac cell development (GO:0055006)3.47063860
36muscle tissue morphogenesis (GO:0060415)3.45036291
37chemosensory behavior (GO:0007635)3.43416882
38dendritic spine organization (GO:0097061)3.41274476
39galactose metabolic process (GO:0006012)3.37091170
40lymphangiogenesis (GO:0001946)3.34416378
41cardiac muscle contraction (GO:0060048)3.32571899
42lateral sprouting from an epithelium (GO:0060601)3.32355277
43carnitine shuttle (GO:0006853)3.30192961
44regulation of membrane repolarization (GO:0060306)3.30110502
45cardiac myofibril assembly (GO:0055003)3.29844395
46prostate gland growth (GO:0060736)3.28362098
47cell communication by electrical coupling (GO:0010644)3.26491819
48muscle hypertrophy (GO:0014896)3.25262920
49ventricular cardiac muscle cell development (GO:0055015)3.23219746
50endocrine hormone secretion (GO:0060986)3.21958370
51myelination in peripheral nervous system (GO:0022011)3.21827778
52peripheral nervous system axon ensheathment (GO:0032292)3.21827778
53relaxation of cardiac muscle (GO:0055119)3.19407645
54actomyosin structure organization (GO:0031032)3.15150503
55detection of calcium ion (GO:0005513)3.14503973
56myofibril assembly (GO:0030239)3.12572423
57hair cell differentiation (GO:0035315)3.11532819
58cell migration involved in heart development (GO:0060973)3.09700839
59regulation of actin filament-based movement (GO:1903115)3.05794287
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05178045
61response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.01976980
62embryonic heart tube development (GO:0035050)3.00739614
63positive regulation of vascular permeability (GO:0043117)3.00593762
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.00526974
65cGMP-mediated signaling (GO:0019934)2.95058436
66arginine metabolic process (GO:0006525)2.93989528
67regulation of cytokine production involved in inflammatory response (GO:1900015)2.93500935
68response to inactivity (GO:0014854)2.93047625
69sarcoplasmic reticulum calcium ion transport (GO:0070296)2.92869466
70DNA deamination (GO:0045006)2.91984340
71actin filament-based movement (GO:0030048)2.91767850
72otic vesicle formation (GO:0030916)2.88382794
73negative regulation of vascular permeability (GO:0043116)2.86823538
74regulation of striated muscle contraction (GO:0006942)2.86378531
75fibril organization (GO:0097435)2.86311669
76cardiac muscle cell action potential (GO:0086001)2.85177710
77regulation of heart rate (GO:0002027)2.83799186
78positive regulation of heart rate (GO:0010460)2.83462013
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.82318247
80ventricular cardiac muscle cell action potential (GO:0086005)2.80961515
81cellular response to epinephrine stimulus (GO:0071872)2.80442571
82extracellular fibril organization (GO:0043206)2.80030542
83cardiac muscle hypertrophy in response to stress (GO:0014898)2.79950908
84muscle hypertrophy in response to stress (GO:0003299)2.79950908
85cardiac muscle adaptation (GO:0014887)2.79950908
86protein polyglutamylation (GO:0018095)2.78909628
87negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77401074
88motile cilium assembly (GO:0044458)2.75954399
89heart process (GO:0003015)2.75899496
90heart contraction (GO:0060047)2.75899496
91negative regulation of organelle assembly (GO:1902116)2.74146080
92anterior/posterior axis specification (GO:0009948)2.73883727
93vocalization behavior (GO:0071625)2.71691471
94cardiac muscle tissue development (GO:0048738)2.71385950
95fatty acid transmembrane transport (GO:1902001)2.71125899
96regulation of relaxation of muscle (GO:1901077)2.70712343
97DNA double-strand break processing (GO:0000729)2.69881759
98positive regulation of fatty acid oxidation (GO:0046321)2.69770456
99extracellular matrix assembly (GO:0085029)2.68646256
100mesonephros development (GO:0001823)2.67849719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66538219
2GBX2_23144817_ChIP-Seq_PC3_Human3.37207818
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.05227525
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80278209
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74588172
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.71427013
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.50656693
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.46436100
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.39108838
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37989436
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29910087
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17993020
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12590140
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10121870
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.08637996
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00811497
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99910982
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99910982
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.99619359
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97949616
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95003051
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89194612
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83662989
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83118625
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.80767092
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80128015
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76611843
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75320790
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75229164
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72733529
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71889747
32VDR_22108803_ChIP-Seq_LS180_Human1.70227735
33SMAD4_21799915_ChIP-Seq_A2780_Human1.68488263
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68433039
35RNF2_27304074_Chip-Seq_NSC_Mouse1.67032785
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66898656
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64603419
38P300_19829295_ChIP-Seq_ESCs_Human1.60761885
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59245327
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58305347
41CJUN_26792858_Chip-Seq_BT549_Human1.55863198
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54984535
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52985837
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.52682043
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50476556
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50200129
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.44683840
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43265071
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.41320794
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40517974
51BCAT_22108803_ChIP-Seq_LS180_Human1.36544455
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36104764
53TBX3_20139965_ChIP-Seq_ESCs_Mouse1.35626584
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35256660
55TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35107256
56TAF15_26573619_Chip-Seq_HEK293_Human1.34676434
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.33571429
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.33509343
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.32805406
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.31877438
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31727460
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.30108019
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29990304
64TP53_16413492_ChIP-PET_HCT116_Human1.29530573
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28747697
66LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28449710
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28224409
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27494012
69STAT3_23295773_ChIP-Seq_U87_Human1.27111793
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26372809
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24992488
72FUS_26573619_Chip-Seq_HEK293_Human1.23093870
73TP53_18474530_ChIP-ChIP_U2OS_Human1.22008684
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20996752
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20996752
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18523168
77HTT_18923047_ChIP-ChIP_STHdh_Human1.17953521
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.16967894
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.16615600
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15962948
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13955774
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13309262
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13133203
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13133203
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13133203
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12602607
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12411463
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.08705998
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08246395
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06224449
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.06210903
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.04916081
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.04916081
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04901235
95CBP_20019798_ChIP-Seq_JUKART_Human1.04109245
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04109245
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03557768
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03542990
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02013610
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00411681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.11058998
2MP0003646_muscle_fatigue4.32763427
3MP0002837_dystrophic_cardiac_calcinosis3.56908202
4MP0004084_abnormal_cardiac_muscle3.54107382
5MP0005503_abnormal_tendon_morphology3.50186165
6MP0001661_extended_life_span3.49804067
7MP0005409_darkened_coat_color3.42189464
8MP0004215_abnormal_myocardial_fiber3.21678411
9MP0004036_abnormal_muscle_relaxation3.19018205
10MP0004510_myositis2.98200070
11MP0005275_abnormal_skin_tensile2.74285664
12MP0010368_abnormal_lymphatic_system2.50940907
13MP0009384_cardiac_valve_regurgitation2.47601644
14MP0004272_abnormal_basement_membrane2.45094671
15MP0008004_abnormal_stomach_pH2.41666766
16MP0001879_abnormal_lymphatic_vessel2.38285199
17MP0003137_abnormal_impulse_conducting2.38222183
18MP0000749_muscle_degeneration2.32242938
19MP0002108_abnormal_muscle_morphology2.07950864
20MP0008438_abnormal_cutaneous_collagen2.06764746
21MP0006138_congestive_heart_failure1.94097062
22MP0002106_abnormal_muscle_physiology1.92993523
23MP0010030_abnormal_orbit_morphology1.91081694
24MP0005620_abnormal_muscle_contractility1.91017645
25MP0005369_muscle_phenotype1.86551045
26MP0004484_altered_response_of1.86349181
27MP0005330_cardiomyopathy1.83106333
28MP0004145_abnormal_muscle_electrophysio1.82280333
29MP0004147_increased_porphyrin_level1.79239340
30MP0000750_abnormal_muscle_regeneration1.76791892
31MP0002269_muscular_atrophy1.73795571
32MP0002638_abnormal_pupillary_reflex1.64565759
33MP0008775_abnormal_heart_ventricle1.62453878
34MP0002127_abnormal_cardiovascular_syste1.59743531
35MP0006072_abnormal_retinal_apoptosis1.58897587
36MP0004087_abnormal_muscle_fiber1.58782419
37MP0001986_abnormal_taste_sensitivity1.57819573
38MP0002972_abnormal_cardiac_muscle1.55504621
39MP0002822_catalepsy1.43014004
40MP0005595_abnormal_vascular_smooth1.43013208
41MP0005385_cardiovascular_system_phenoty1.42324847
42MP0001544_abnormal_cardiovascular_syste1.42324847
43MP0005165_increased_susceptibility_to1.37738654
44MP0006276_abnormal_autonomic_nervous1.35141224
45MP0003279_aneurysm1.25239476
46MP0002932_abnormal_joint_morphology1.23313447
47MP0000579_abnormal_nail_morphology1.19850093
48MP0005508_abnormal_skeleton_morphology1.18228452
49MP0000462_abnormal_digestive_system1.17452270
50MP0003122_maternal_imprinting1.17223845
51MP0000747_muscle_weakness1.14469742
52MP0002933_joint_inflammation1.11362291
53MP0000767_abnormal_smooth_muscle1.11084488
54MP0002277_abnormal_respiratory_mucosa1.05653741
55MP0000759_abnormal_skeletal_muscle1.01751607
56MP0003567_abnormal_fetal_cardiomyocyte1.00371731
57MP0002295_abnormal_pulmonary_circulatio0.99166607
58MP0008995_early_reproductive_senescence0.98009027
59MP0004085_abnormal_heartbeat0.96635747
60MP0000230_abnormal_systemic_arterial0.94585280
61MP0002909_abnormal_adrenal_gland0.94202922
62MP0004142_abnormal_muscle_tone0.92885319
63MP0000383_abnormal_hair_follicle0.90915394
64MP0001958_emphysema0.88713057
65MP0010386_abnormal_urinary_bladder0.88426933
66MP0000733_abnormal_muscle_development0.87722834
67MP0005171_absent_coat_pigmentation0.83783221
68MP0002128_abnormal_blood_circulation0.83438738
69MP0003045_fibrosis0.81811697
70MP0010630_abnormal_cardiac_muscle0.81228237
71MP0000566_synostosis0.80021030
72MP0000467_abnormal_esophagus_morphology0.79122068
73MP0009250_abnormal_appendicular_skeleto0.76996182
74MP0001542_abnormal_bone_strength0.74877174
75MP0001299_abnormal_eye_distance/0.74735731
76MP0002254_reproductive_system_inflammat0.71250379
77MP0001486_abnormal_startle_reflex0.71059451
78MP0003828_pulmonary_edema0.70115855
79MP0000163_abnormal_cartilage_morphology0.69621832
80MP0000569_abnormal_digit_pigmentation0.69570705
81MP0000026_abnormal_inner_ear0.68964551
82MP0000762_abnormal_tongue_morphology0.68495829
83MP0002102_abnormal_ear_morphology0.66171526
84MP0000049_abnormal_middle_ear0.64983706
85MP0005670_abnormal_white_adipose0.62724338
86MP0000639_abnormal_adrenal_gland0.61921375
87MP0003937_abnormal_limbs/digits/tail_de0.59805531
88MP0001286_abnormal_eye_development0.59372312
89MP0003283_abnormal_digestive_organ0.58449517
90MP0002332_abnormal_exercise_endurance0.57404195
91MP0002089_abnormal_postnatal_growth/wei0.56960731
92MP0005253_abnormal_eye_physiology0.55817323
93MP0000266_abnormal_heart_morphology0.55619664
94MP0005023_abnormal_wound_healing0.55200302
95MP0001963_abnormal_hearing_physiology0.54482413
96MP0000778_abnormal_nervous_system0.54464765
97MP0000537_abnormal_urethra_morphology0.52883339
98MP0009046_muscle_twitch0.50105326
99MP0003763_abnormal_thymus_physiology0.49830499
100MP0002282_abnormal_trachea_morphology0.48657424

Predicted human phenotypes

RankGene SetZ-score
1Anomalous pulmonary venous return (HP:0010772)5.50873574
2Tongue fasciculations (HP:0001308)5.17706302
3Abnormality of the pulmonary veins (HP:0011718)4.84899475
4Muscle fibrillation (HP:0010546)4.65918446
5Bundle branch block (HP:0011710)4.52809739
6Rib fusion (HP:0000902)4.44275491
7Atrial fibrillation (HP:0005110)4.13927072
8Sudden death (HP:0001699)4.05902738
9Syncope (HP:0001279)3.88647529
10Aplastic anemia (HP:0001915)3.78884679
11Muscle fiber splitting (HP:0003555)3.74359282
12Aplasia of the musculature (HP:0100854)3.72799959
13Abnormality of the calf musculature (HP:0001430)3.69688235
14Primary atrial arrhythmia (HP:0001692)3.57804055
15Lipoatrophy (HP:0100578)3.46681673
16Supraventricular tachycardia (HP:0004755)3.36669909
17Confusion (HP:0001289)3.34829900
18Supraventricular arrhythmia (HP:0005115)3.28439506
19Long clavicles (HP:0000890)3.27247707
20Slow saccadic eye movements (HP:0000514)3.24406189
21Aortic aneurysm (HP:0004942)3.22063980
22Popliteal pterygium (HP:0009756)3.19572503
23Ventricular tachycardia (HP:0004756)3.16378079
24Joint hemorrhage (HP:0005261)2.97339291
25Right ventricular cardiomyopathy (HP:0011663)2.93259140
26Calf muscle hypertrophy (HP:0008981)2.92785960
27Adactyly (HP:0009776)2.92417026
28Respiratory distress (HP:0002098)2.86247496
29Hyporeflexia of lower limbs (HP:0002600)2.80496154
30Absent hand (HP:0004050)2.67365094
31Type 1 muscle fiber predominance (HP:0003803)2.63811278
32Muscle hypertrophy of the lower extremities (HP:0008968)2.61497689
33Ventricular arrhythmia (HP:0004308)2.58144324
34Aortic dissection (HP:0002647)2.53664438
35Fused cervical vertebrae (HP:0002949)2.50492755
36Prolonged QT interval (HP:0001657)2.46269493
37Symphalangism affecting the phalanges of the hand (HP:0009773)2.44631395
38Pigmentary retinal degeneration (HP:0001146)2.42528180
39Fetal akinesia sequence (HP:0001989)2.40851710
40Abnormality of the labia majora (HP:0012881)2.35250295
41Dilated cardiomyopathy (HP:0001644)2.33997690
42Pulmonary artery stenosis (HP:0004415)2.29390585
43Prolonged partial thromboplastin time (HP:0003645)2.28940908
44Neonatal respiratory distress (HP:0002643)2.25723568
45Sparse lateral eyebrow (HP:0005338)2.23553598
46Ventricular fibrillation (HP:0001663)2.21615304
47Hypoplasia of the iris (HP:0007676)2.18985171
48Difficulty running (HP:0009046)2.18596570
49Patent foramen ovale (HP:0001655)2.18050769
50Palpitations (HP:0001962)2.14082971
51Heart block (HP:0012722)2.13947285
52Mesangial abnormality (HP:0001966)2.13604883
53Cutaneous melanoma (HP:0012056)2.12388117
54EMG: myopathic abnormalities (HP:0003458)2.11453057
55Abnormality of incisor morphology (HP:0011063)2.11196446
56Abnormality of the intervertebral disk (HP:0005108)2.08983359
57Tubulointerstitial fibrosis (HP:0005576)2.08018736
58Abnormality of placental membranes (HP:0011409)2.06595272
59Amniotic constriction ring (HP:0009775)2.06595272
60Abnormal number of erythroid precursors (HP:0012131)2.02184939
61Preauricular pit (HP:0004467)1.99985314
62Periauricular skin pits (HP:0100277)1.99985314
63Anterior segment dysgenesis (HP:0007700)1.99302509
64Abnormal atrioventricular conduction (HP:0005150)1.98925604
65Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98344003
66Impaired smooth pursuit (HP:0007772)1.95847889
67Muscular dystrophy (HP:0003560)1.92096781
68Abnormality of the middle phalanges of the toes (HP:0010183)1.91539041
69Absent toe (HP:0010760)1.90320786
70Abnormality of chloride homeostasis (HP:0011422)1.89787917
71Recurrent corneal erosions (HP:0000495)1.88829013
72Hydroureter (HP:0000072)1.87473627
73Abnormal EKG (HP:0003115)1.87362440
74Short tibia (HP:0005736)1.85903825
75Split foot (HP:0001839)1.85641186
76Stenosis of the external auditory canal (HP:0000402)1.83345366
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82826563
78Aplasia/Hypoplasia of the hallux (HP:0008362)1.82076575
79Short hallux (HP:0010109)1.80074315
80Ankle contracture (HP:0006466)1.78563794
81Malignant hyperthermia (HP:0002047)1.77758887
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.76669178
83Aplasia involving bones of the upper limbs (HP:0009823)1.75157993
84Aplasia of the phalanges of the hand (HP:0009802)1.75157993
85Aplasia involving bones of the extremities (HP:0009825)1.75157993
86Muscle fiber inclusion bodies (HP:0100299)1.74251502
87Abnormal pupillary function (HP:0007686)1.72037132
88Molar tooth sign on MRI (HP:0002419)1.70534944
89Abnormality of midbrain morphology (HP:0002418)1.70534944
90Alacrima (HP:0000522)1.70352890
91Abnormality of the 2nd finger (HP:0004100)1.70302328
92Small epiphyses (HP:0010585)1.69933082
93Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66809868
94Hyperammonemia (HP:0001987)1.66455940
95Proximal amyotrophy (HP:0007126)1.65887901
96Irregular vertebral endplates (HP:0003301)1.65592024
97Hypoplastic nipples (HP:0002557)1.63652953
98Left ventricular hypertrophy (HP:0001712)1.63464003
99Maternal diabetes (HP:0009800)1.62293757
100Neck muscle weakness (HP:0000467)1.61952022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.32267184
2STK38L4.15399208
3MYLK3.91972141
4OBSCN3.23691364
5TIE12.94781022
6MAP4K22.62391015
7MELK2.54038821
8PBK2.52952655
9TTN2.40779785
10MST42.25688391
11AKT32.01226838
12KDR1.81950950
13PDGFRB1.75908447
14EPHA31.67656087
15ZAP701.61016199
16FGFR21.59213632
17LATS11.57570989
18STK241.48559449
19NEK11.39282408
20DMPK1.39101217
21BMPR1B1.37050860
22LIMK11.30235012
23CSK1.24912100
24STK381.24576443
25LATS21.24514490
26PDK21.23146984
27EIF2AK31.21895131
28MARK11.18593637
29WNK31.12167293
30WEE11.10038113
31BRSK21.07487186
32MUSK1.06326161
33TNIK1.03644464
34NEK90.98311310
35AKT20.98006424
36MAP3K70.97737977
37NTRK10.94921122
38MAP3K120.94408453
39FES0.93183023
40SCYL20.91283945
41ADRBK10.88369548
42STK40.87747448
43ROCK10.82581706
44ABL20.82220729
45TESK10.81447921
46PIK3CA0.80095820
47CAMK2D0.79873873
48PDGFRA0.77963697
49NLK0.77827824
50PRKD10.75539503
51PINK10.74974191
52PKN10.74612894
53SYK0.73107929
54PTK2B0.72641112
55BRSK10.65796147
56NUAK10.64241820
57TRPM70.62701904
58GRK10.60993593
59MAP3K60.60892060
60DYRK1B0.59939640
61PAK30.59933270
62INSRR0.59832200
63MAPK120.58957774
64ADRBK20.57663173
65MAPK70.57188069
66PRKAA20.56928883
67CDK80.56555903
68ROCK20.53081463
69CAMK2A0.52403022
70INSR0.52382229
71MAP3K100.51670096
72ATR0.51365840
73FGFR10.50507932
74TGFBR20.48434778
75CAMK40.48184087
76TGFBR10.47639181
77PRKCE0.47288536
78CAMK2B0.47125750
79ERBB40.45469001
80SGK20.44647134
81BMX0.44344243
82MAPK150.42774400
83PRKACA0.41860061
84LMTK20.40957503
85DAPK20.40940765
86MET0.39806299
87STK110.38721455
88SGK4940.38401544
89SGK2230.38401544
90TLK10.37070774
91ERBB20.36243132
92DDR20.35316305
93EGFR0.34273870
94TAOK10.33270191
95MAPK40.32427155
96MAPK130.32099145
97FRK0.31692464
98PRKAA10.30588161
99FER0.30415121
100UHMK10.30323493

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.93405946
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.48571651
3Dilated cardiomyopathy_Homo sapiens_hsa054144.24093699
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.10103653
5Arginine biosynthesis_Homo sapiens_hsa002203.20849508
6Cardiac muscle contraction_Homo sapiens_hsa042602.70420191
7ECM-receptor interaction_Homo sapiens_hsa045122.52315612
8Protein digestion and absorption_Homo sapiens_hsa049741.84344883
9Adherens junction_Homo sapiens_hsa045201.75733395
10Vascular smooth muscle contraction_Homo sapiens_hsa042701.75664505
11Pancreatic secretion_Homo sapiens_hsa049721.67386354
12Basal cell carcinoma_Homo sapiens_hsa052171.57217626
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55502685
14Focal adhesion_Homo sapiens_hsa045101.53759276
15Olfactory transduction_Homo sapiens_hsa047401.49892589
16TGF-beta signaling pathway_Homo sapiens_hsa043501.44790340
17Sulfur metabolism_Homo sapiens_hsa009201.40471543
18Renin secretion_Homo sapiens_hsa049241.32756613
19Malaria_Homo sapiens_hsa051441.32752513
20Fanconi anemia pathway_Homo sapiens_hsa034601.30338564
21Calcium signaling pathway_Homo sapiens_hsa040201.22604127
22Circadian rhythm_Homo sapiens_hsa047101.17374906
23Linoleic acid metabolism_Homo sapiens_hsa005911.15753082
24Propanoate metabolism_Homo sapiens_hsa006401.15113195
25Hippo signaling pathway_Homo sapiens_hsa043901.13643772
26Circadian entrainment_Homo sapiens_hsa047131.10629888
27Fat digestion and absorption_Homo sapiens_hsa049751.09135462
28cAMP signaling pathway_Homo sapiens_hsa040241.01426525
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00966737
30Viral myocarditis_Homo sapiens_hsa054160.98796008
31Gastric acid secretion_Homo sapiens_hsa049710.98300476
32Fatty acid biosynthesis_Homo sapiens_hsa000610.98180318
33Oxytocin signaling pathway_Homo sapiens_hsa049210.94844256
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94214798
35Adipocytokine signaling pathway_Homo sapiens_hsa049200.93814708
36Homologous recombination_Homo sapiens_hsa034400.91256271
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90445072
38Glutamatergic synapse_Homo sapiens_hsa047240.88194951
39Fatty acid degradation_Homo sapiens_hsa000710.88185435
40Ovarian steroidogenesis_Homo sapiens_hsa049130.87755243
41Systemic lupus erythematosus_Homo sapiens_hsa053220.87291545
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86954643
43Tight junction_Homo sapiens_hsa045300.86573641
44Regulation of autophagy_Homo sapiens_hsa041400.83619394
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82905399
46Phototransduction_Homo sapiens_hsa047440.81137903
47PPAR signaling pathway_Homo sapiens_hsa033200.80107396
48Complement and coagulation cascades_Homo sapiens_hsa046100.79824881
49Amphetamine addiction_Homo sapiens_hsa050310.78935563
50ABC transporters_Homo sapiens_hsa020100.78661142
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78555415
52Parkinsons disease_Homo sapiens_hsa050120.78183663
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78073666
54Insulin secretion_Homo sapiens_hsa049110.77939749
55Oxidative phosphorylation_Homo sapiens_hsa001900.75868710
56FoxO signaling pathway_Homo sapiens_hsa040680.73371539
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73069752
58Nitrogen metabolism_Homo sapiens_hsa009100.72562609
59Proteoglycans in cancer_Homo sapiens_hsa052050.71669825
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71556544
61Hedgehog signaling pathway_Homo sapiens_hsa043400.67413076
62Alzheimers disease_Homo sapiens_hsa050100.67043226
63Rap1 signaling pathway_Homo sapiens_hsa040150.66633896
64Retinol metabolism_Homo sapiens_hsa008300.64250559
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63196607
66Melanogenesis_Homo sapiens_hsa049160.62480643
67GABAergic synapse_Homo sapiens_hsa047270.59230183
68Wnt signaling pathway_Homo sapiens_hsa043100.59098839
69Axon guidance_Homo sapiens_hsa043600.58954521
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58893956
71Alcoholism_Homo sapiens_hsa050340.57505899
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56816679
73Platelet activation_Homo sapiens_hsa046110.54382465
74Arachidonic acid metabolism_Homo sapiens_hsa005900.52395001
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52222985
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51614973
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51203573
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.50605091
79Phenylalanine metabolism_Homo sapiens_hsa003600.46790434
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46645962
81Amoebiasis_Homo sapiens_hsa051460.45511034
82Pathways in cancer_Homo sapiens_hsa052000.45359613
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44751868
84Salivary secretion_Homo sapiens_hsa049700.43990530
85Huntingtons disease_Homo sapiens_hsa050160.43975011
86Dopaminergic synapse_Homo sapiens_hsa047280.42503443
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40975966
88Tyrosine metabolism_Homo sapiens_hsa003500.39664680
89Mineral absorption_Homo sapiens_hsa049780.39284889
90Ras signaling pathway_Homo sapiens_hsa040140.38583742
91Basal transcription factors_Homo sapiens_hsa030220.38270417
92Gap junction_Homo sapiens_hsa045400.37606960
93Taste transduction_Homo sapiens_hsa047420.36120748
94MicroRNAs in cancer_Homo sapiens_hsa052060.35446847
95Renin-angiotensin system_Homo sapiens_hsa046140.33872288
96Serotonergic synapse_Homo sapiens_hsa047260.30203081
97Nicotine addiction_Homo sapiens_hsa050330.29865093
98Chemical carcinogenesis_Homo sapiens_hsa052040.29691291
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29587495
100Cholinergic synapse_Homo sapiens_hsa047250.29507603

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