MET

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tyrosine metabolic process (GO:0006570)8.46564749
2hemidesmosome assembly (GO:0031581)8.09587750
3ketone body metabolic process (GO:1902224)6.15088753
4cell adhesion mediated by integrin (GO:0033627)5.97296094
5desmosome organization (GO:0002934)5.63269039
6L-phenylalanine catabolic process (GO:0006559)5.08664957
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.08664957
8aromatic amino acid family metabolic process (GO:0009072)4.94860276
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.92799219
10L-phenylalanine metabolic process (GO:0006558)4.92799219
11membrane raft organization (GO:0031579)4.82227790
12secondary metabolic process (GO:0019748)4.67705539
13skin morphogenesis (GO:0043589)4.66568634
14aromatic amino acid family catabolic process (GO:0009074)4.62865522
15cell-substrate junction assembly (GO:0007044)4.57262071
16cysteine metabolic process (GO:0006534)4.54648359
17COPI coating of Golgi vesicle (GO:0048205)4.46946431
18Golgi transport vesicle coating (GO:0048200)4.46946431
19short-chain fatty acid metabolic process (GO:0046459)4.44728387
20glyoxylate metabolic process (GO:0046487)4.35450665
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.29836660
22tryptophan metabolic process (GO:0006568)4.27895206
23protein carboxylation (GO:0018214)4.26988178
24peptidyl-glutamic acid carboxylation (GO:0017187)4.26988178
25kynurenine metabolic process (GO:0070189)4.25633400
26tryptophan catabolic process (GO:0006569)4.21077031
27indole-containing compound catabolic process (GO:0042436)4.21077031
28indolalkylamine catabolic process (GO:0046218)4.21077031
29urea cycle (GO:0000050)4.20200036
30urea metabolic process (GO:0019627)4.20200036
31alpha-linolenic acid metabolic process (GO:0036109)4.19514560
32nuclear pore complex assembly (GO:0051292)4.19054609
33phenol-containing compound biosynthetic process (GO:0046189)4.17733708
34sulfur amino acid catabolic process (GO:0000098)4.10334475
35mesodermal cell differentiation (GO:0048333)4.09218003
36cellular glucuronidation (GO:0052695)4.08046488
37lysine catabolic process (GO:0006554)4.06413520
38lysine metabolic process (GO:0006553)4.06413520
39bile acid biosynthetic process (GO:0006699)4.04849792
40regulation of transforming growth factor beta2 production (GO:0032909)3.98131254
41protein localization to endosome (GO:0036010)3.96853158
42homocysteine metabolic process (GO:0050667)3.96337380
43dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.95918169
44complement activation, alternative pathway (GO:0006957)3.95903797
45regulation of protein activation cascade (GO:2000257)3.90888783
46plasma lipoprotein particle clearance (GO:0034381)3.88839575
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.85940992
48glucuronate metabolic process (GO:0019585)3.83409730
49uronic acid metabolic process (GO:0006063)3.83409730
50negative regulation of fibrinolysis (GO:0051918)3.80779015
51keratinocyte proliferation (GO:0043616)3.78891346
52nitrogen cycle metabolic process (GO:0071941)3.76051602
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.75430761
54regulation of complement activation (GO:0030449)3.70738940
55low-density lipoprotein particle clearance (GO:0034383)3.68781214
56protein hydroxylation (GO:0018126)3.66857500
57positive regulation of osteoblast proliferation (GO:0033690)3.66775603
58regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.59380711
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59117121
60activation of Rac GTPase activity (GO:0032863)3.58192442
61hepatocyte differentiation (GO:0070365)3.57893956
62hypotonic response (GO:0006971)3.57302750
63high-density lipoprotein particle remodeling (GO:0034375)3.56724535
64developmental pigmentation (GO:0048066)3.56637093
65regulation of fibrinolysis (GO:0051917)3.55735675
66amino-acid betaine metabolic process (GO:0006577)3.53088416
67cellular ketone body metabolic process (GO:0046950)3.51098359
68regulation of cholesterol homeostasis (GO:2000188)3.50273754
69regulation of triglyceride catabolic process (GO:0010896)3.46834673
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.42156211
71bile acid metabolic process (GO:0008206)3.42150579
72nuclear pore organization (GO:0006999)3.40225458
73serine family amino acid catabolic process (GO:0009071)3.40117661
74protein retention in ER lumen (GO:0006621)3.37838619
75negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.36476788
76aldehyde catabolic process (GO:0046185)3.33334702
77regulation of mitotic spindle organization (GO:0060236)3.29212270
78negative regulation of sterol transport (GO:0032372)3.29093511
79negative regulation of cholesterol transport (GO:0032375)3.29093511
80fibrinolysis (GO:0042730)3.28827865
81reverse cholesterol transport (GO:0043691)3.26621052
82epithelial cell-cell adhesion (GO:0090136)3.25299998
83cellular modified amino acid catabolic process (GO:0042219)3.24558705
84substrate-dependent cell migration (GO:0006929)3.23304544
85macromolecular complex remodeling (GO:0034367)3.22046952
86plasma lipoprotein particle remodeling (GO:0034369)3.22046952
87protein-lipid complex remodeling (GO:0034368)3.22046952
88polyketide metabolic process (GO:0030638)3.21453310
89doxorubicin metabolic process (GO:0044598)3.21453310
90daunorubicin metabolic process (GO:0044597)3.21453310
91urate metabolic process (GO:0046415)3.21340215
92valine metabolic process (GO:0006573)3.20278830
93triglyceride homeostasis (GO:0070328)3.19935723
94acylglycerol homeostasis (GO:0055090)3.19935723
95positive regulation of lipid catabolic process (GO:0050996)3.18808853
96endodermal cell differentiation (GO:0035987)3.18740422
97phospholipid efflux (GO:0033700)3.17549226
98dicarboxylic acid biosynthetic process (GO:0043650)3.14943111
99negative regulation of chondrocyte differentiation (GO:0032331)3.13728322
100glutamate metabolic process (GO:0006536)3.12937420
101retina vasculature morphogenesis in camera-type eye (GO:0061299)3.12767800
102alpha-amino acid catabolic process (GO:1901606)3.10594128
103cholesterol efflux (GO:0033344)3.10474090
104negative regulation of keratinocyte proliferation (GO:0010839)3.10405758
105drug transmembrane transport (GO:0006855)3.09230415
106phospholipid homeostasis (GO:0055091)3.08006095
107drug catabolic process (GO:0042737)3.07852352
108cytoskeletal anchoring at plasma membrane (GO:0007016)3.07159005
109indolalkylamine metabolic process (GO:0006586)3.07125150
110pore complex assembly (GO:0046931)3.05739852
111negative regulation of fatty acid biosynthetic process (GO:0045717)3.05729213
112flavonoid metabolic process (GO:0009812)3.04988153
1132-oxoglutarate metabolic process (GO:0006103)3.04819553
114acute-phase response (GO:0006953)3.04626758
115mammary gland epithelial cell proliferation (GO:0033598)3.04088633
116regulation of metalloenzyme activity (GO:0048552)3.01984111
117ethanol oxidation (GO:0006069)2.99986465
118regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.99185072
1194-hydroxyproline metabolic process (GO:0019471)2.98715741
120negative regulation of anoikis (GO:2000811)2.97082469
121benzene-containing compound metabolic process (GO:0042537)2.96694791
122pigment biosynthetic process (GO:0046148)2.96025804
123lipoprotein metabolic process (GO:0042157)2.93838660
124bile acid and bile salt transport (GO:0015721)2.93769182
125regulation of cholesterol esterification (GO:0010872)2.93358110
126cell-substrate adherens junction assembly (GO:0007045)2.91669773
127focal adhesion assembly (GO:0048041)2.91669773
128serine family amino acid metabolic process (GO:0009069)2.91465419
129nucleobase-containing small molecule interconversion (GO:0015949)2.91223793
130bone remodeling (GO:0046849)2.91223355
131lung vasculature development (GO:0060426)2.91001269
132cellular amino acid catabolic process (GO:0009063)2.90144259
133coenzyme catabolic process (GO:0009109)2.88811495
134surfactant homeostasis (GO:0043129)2.88748982
135acetyl-CoA metabolic process (GO:0006084)2.88331422
136plasma lipoprotein particle assembly (GO:0034377)2.87705933
137cellular response to vitamin D (GO:0071305)2.87653898
138sterol homeostasis (GO:0055092)2.86641072
139negative regulation of lipase activity (GO:0060192)2.86079059
140very-low-density lipoprotein particle assembly (GO:0034379)2.85547817
141cholesterol homeostasis (GO:0042632)2.85261973
142plasma membrane repair (GO:0001778)2.83848794
143positive regulation of blood coagulation (GO:0030194)2.83684714
144positive regulation of hemostasis (GO:1900048)2.83684714
145aminoglycoside antibiotic metabolic process (GO:0030647)2.82936616
146glomerular visceral epithelial cell development (GO:0072015)2.82916584
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82863514
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.80840436
149peptidyl-proline hydroxylation (GO:0019511)2.80753409
150pigment metabolic process (GO:0042440)2.80710537
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.79521076
152adherens junction assembly (GO:0034333)2.78261187
153protein localization to microtubule (GO:0035372)2.75303094
154branching involved in mammary gland duct morphogenesis (GO:0060444)2.75270264
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74895438
156mitotic cytokinesis (GO:0000281)2.73197519
157cellular protein complex localization (GO:0034629)2.72443201
158mitotic chromosome condensation (GO:0007076)2.71114986
159gap junction assembly (GO:0016264)2.70333506
160COPII vesicle coating (GO:0048208)2.69937106
161hippo signaling (GO:0035329)2.69050782
162notochord development (GO:0030903)2.67113773
163regulation of anoikis (GO:2000209)2.65209821
164iron ion import (GO:0097286)2.64714307
165diterpenoid biosynthetic process (GO:0016102)2.63213518
166glucose catabolic process (GO:0006007)2.61891700
167membrane protein ectodomain proteolysis (GO:0006509)2.61591317
168ribosome assembly (GO:0042255)2.61446040
169positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.60762381
170pentose-phosphate shunt (GO:0006098)2.57245979
171regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.55014732
172retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53909436
173glomerular epithelial cell development (GO:0072310)2.49881787
174glucose 6-phosphate metabolic process (GO:0051156)2.49817153
175renal filtration (GO:0097205)2.46980104
176cellular response to vitamin (GO:0071295)2.46690668
177vesicle coating (GO:0006901)2.45935871
178regulation of spindle organization (GO:0090224)2.45796257
179cytoskeleton-dependent cytokinesis (GO:0061640)2.45765635
180regulation of glucose import in response to insulin stimulus (GO:2001273)2.44513293
181positive regulation of protein localization to plasma membrane (GO:1903078)2.44174357
182cell junction assembly (GO:0034329)2.43538451
183regulation of translational fidelity (GO:0006450)2.41573111
184nucleotide-sugar biosynthetic process (GO:0009226)2.40658858
185tight junction assembly (GO:0070830)2.40469091
186regulation of hippo signaling (GO:0035330)2.39888954
187positive regulation of extracellular matrix organization (GO:1903055)2.38755791
188retinal metabolic process (GO:0042574)2.36432804
189wound healing, spreading of epidermal cells (GO:0035313)2.36161330
190basement membrane organization (GO:0071711)2.35747549
191apoptotic cell clearance (GO:0043277)2.33948430
192membrane assembly (GO:0071709)2.32947638
193negative regulation of fatty acid transport (GO:2000192)2.32573177
194receptor catabolic process (GO:0032801)2.31185051
195regulation of osteoblast proliferation (GO:0033688)2.30883127
196chemical homeostasis within a tissue (GO:0048875)2.28986940
197melanin biosynthetic process (GO:0042438)12.7204054
198melanin metabolic process (GO:0006582)11.4577315
199secondary metabolite biosynthetic process (GO:0044550)11.0255115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.11666198
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.98855039
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.18094364
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.81851590
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.47646851
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.41226812
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.62103698
8E2F7_22180533_ChIP-Seq_HELA_Human3.33379810
9AR_21909140_ChIP-Seq_LNCAP_Human3.24421674
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.14041560
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.07308973
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.06873069
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.96455403
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.81864171
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51337911
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.46049605
17CLOCK_20551151_ChIP-Seq_293T_Human2.43528745
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23135630
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22669904
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.18993766
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17919316
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14258327
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11513138
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01069892
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.96750761
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94581072
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83761077
28* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81253708
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81252049
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80677821
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74962387
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.70240670
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.68022411
34GATA1_22025678_ChIP-Seq_K562_Human1.67389114
35ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.62256986
36UBF1/2_26484160_Chip-Seq_HMECs_Human1.61837518
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57845795
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57087272
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.56670757
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.56114290
41* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55562290
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.51400961
43* FOXA2_19822575_ChIP-Seq_HepG2_Human1.51258912
44* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49456319
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49310561
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48835786
47GATA4_25053715_ChIP-Seq_YYC3_Human1.46255223
48EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.42303626
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41297304
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41297304
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40193583
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.38149389
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37655641
54* SOX2_20726797_ChIP-Seq_SW620_Human1.36035110
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35956458
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.35527403
57* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34652609
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.32704602
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32325568
60ZNF263_19887448_ChIP-Seq_K562_Human1.32296271
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31767910
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.27734041
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27087206
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24738993
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.24687077
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24452019
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.24409122
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24212923
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24212923
70CJUN_26792858_Chip-Seq_BT549_Human1.24205456
71* HNF4A_19822575_ChIP-Seq_HepG2_Human1.23971472
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.22748885
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21842213
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.21722796
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19012254
76EGR1_19032775_ChIP-ChIP_M12_Human1.19000644
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18965673
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.17951243
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17899629
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15689845
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15084548
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14512772
83TP53_22127205_ChIP-Seq_IMR90_Human1.14248993
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11645093
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09247449
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.08614817
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07966779
88GATA6_25053715_ChIP-Seq_YYC3_Human1.07391160
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05860011
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05801192
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05603795
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05046573
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04474625
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03885198
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03815594
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.03207405
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03189370
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03019578
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02516951
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02331830
101KLF5_25053715_ChIP-Seq_YYC3_Human1.01836959
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01615079
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00893110
104* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99419865
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98057527
106AHR_22903824_ChIP-Seq_MCF-7_Human0.96882074
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95472560
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94839832
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94010577
110CHD1_26751641_Chip-Seq_LNCaP_Human0.91336104
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90743442
112DCP1A_22483619_ChIP-Seq_HELA_Human0.90587000
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89293067
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.88070016
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.87806661
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87377789
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87103238
118ATF3_27146783_Chip-Seq_COLON_Human0.86712391
119* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86517985
120VDR_24787735_ChIP-Seq_THP-1_Human0.85715678
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82912277
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82496299
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.81779251
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81765515
125* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80426353
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79571753
127* TP63_23658742_ChIP-Seq_EP156T_Human0.79229805
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79179759
129RACK7_27058665_Chip-Seq_MCF-7_Human0.77690122
130* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77207494
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76667633
132TP53_18474530_ChIP-ChIP_U2OS_Human0.76345737
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.74502419
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73620966
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.73178157
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.73178157
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73144186
138* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72511183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation7.14180191
2MP0005171_absent_coat_pigmentation5.47476668
3MP0002139_abnormal_hepatobiliary_system5.08809298
4MP0005408_hypopigmentation4.73568871
5MP0005360_urolithiasis4.71699427
6MP0004272_abnormal_basement_membrane3.74045041
7MP0003950_abnormal_plasma_membrane3.71114211
8MP0005085_abnormal_gallbladder_physiolo3.39622061
9MP0005365_abnormal_bile_salt3.21942971
10MP0000371_diluted_coat_color3.19400274
11MP0002877_abnormal_melanocyte_morpholog2.94870421
12MP0003136_yellow_coat_color2.87898201
13MP0008875_abnormal_xenobiotic_pharmacok2.85790122
14MP0004381_abnormal_hair_follicle2.78405605
15MP0005257_abnormal_intraocular_pressure2.76503873
16MP0003252_abnormal_bile_duct2.45653130
17MP0003705_abnormal_hypodermis_morpholog2.42493055
18MP0000579_abnormal_nail_morphology2.27542372
19MP0010329_abnormal_lipoprotein_level2.11944517
20MP0010678_abnormal_skin_adnexa2.09916446
21MP0009780_abnormal_chondrocyte_physiolo2.08923817
22MP0005083_abnormal_biliary_tract2.08191457
23MP0009840_abnormal_foam_cell2.07918701
24MP0000537_abnormal_urethra_morphology2.04584152
25MP0005623_abnormal_meninges_morphology1.98221376
26MP0003195_calcinosis1.98206436
27MP0003806_abnormal_nucleotide_metabolis1.93745888
28MP0003191_abnormal_cellular_cholesterol1.91423854
29MP0003941_abnormal_skin_development1.89125500
30MP0002138_abnormal_hepatobiliary_system1.89080175
31MP0005248_abnormal_Harderian_gland1.88412375
32MP0001324_abnormal_eye_pigmentation1.83877546
33MP0010234_abnormal_vibrissa_follicle1.75191681
34MP0005076_abnormal_cell_differentiation1.71032639
35MP0004233_abnormal_muscle_weight1.71002767
36MP0005332_abnormal_amino_acid1.65060158
37MP0005409_darkened_coat_color1.64707123
38* MP0000762_abnormal_tongue_morphology1.62875390
39MP0001849_ear_inflammation1.59485065
40MP0002095_abnormal_skin_pigmentation1.59263145
41MP0003878_abnormal_ear_physiology1.59026836
42MP0005377_hearing/vestibular/ear_phenot1.59026836
43MP0001666_abnormal_nutrient_absorption1.56645324
44MP0001216_abnormal_epidermal_layer1.55306754
45MP0004019_abnormal_vitamin_homeostasis1.52862875
46MP0000383_abnormal_hair_follicle1.50191498
47MP0005501_abnormal_skin_physiology1.47296795
48MP0000467_abnormal_esophagus_morphology1.46392527
49MP0002332_abnormal_exercise_endurance1.42568695
50MP0002075_abnormal_coat/hair_pigmentati1.42051571
51* MP0000609_abnormal_liver_physiology1.35165764
52MP0000013_abnormal_adipose_tissue1.30590172
53MP0000015_abnormal_ear_pigmentation1.29896625
54MP0002896_abnormal_bone_mineralization1.28307981
55MP0001348_abnormal_lacrimal_gland1.23200289
56MP0002118_abnormal_lipid_homeostasis1.21894126
57MP0002254_reproductive_system_inflammat1.21388621
58MP0010030_abnormal_orbit_morphology1.20106506
59MP0000569_abnormal_digit_pigmentation1.19106198
60MP0000003_abnormal_adipose_tissue1.18812652
61MP0001186_pigmentation_phenotype1.18068874
62MP0003453_abnormal_keratinocyte_physiol1.17955049
63MP0004957_abnormal_blastocyst_morpholog1.16016147
64MP0005075_abnormal_melanosome_morpholog1.12811950
65MP0001915_intracranial_hemorrhage1.10832722
66MP0002098_abnormal_vibrissa_morphology1.09719303
67MP0010771_integument_phenotype1.09242990
68MP0005058_abnormal_lysosome_morphology1.09015346
69MP0000627_abnormal_mammary_gland1.08323247
70MP0005165_increased_susceptibility_to1.08227996
71MP0001661_extended_life_span1.08020989
72MP0003186_abnormal_redox_activity1.07393763
73* MP0000733_abnormal_muscle_development1.06916593
74MP0005197_abnormal_uvea_morphology1.04722661
75MP0005319_abnormal_enzyme/_coenzyme1.04621582
76MP0009643_abnormal_urine_homeostasis1.03046528
77MP0002102_abnormal_ear_morphology1.01018508
78MP0003300_gastrointestinal_ulcer1.00747473
79MP0000749_muscle_degeneration1.00275543
80MP0002090_abnormal_vision0.93024542
81MP0009764_decreased_sensitivity_to0.92185953
82MP0000751_myopathy0.91809153
83MP0004782_abnormal_surfactant_physiolog0.91172480
84MP0005621_abnormal_cell_physiology0.90884189
85MP0003566_abnormal_cell_adhesion0.90704615
86MP0004264_abnormal_extraembryonic_tissu0.90682123
87MP0000750_abnormal_muscle_regeneration0.89667882
88* MP0002086_abnormal_extraembryonic_tissu0.87625004
89MP0009697_abnormal_copulation0.87399281
90MP0003868_abnormal_feces_composition0.84613303
91MP0005174_abnormal_tail_pigmentation0.83770245
92MP0002269_muscular_atrophy0.83761668
93MP0005193_abnormal_anterior_eye0.83510361
94MP0003011_delayed_dark_adaptation0.83241352
95MP0008932_abnormal_embryonic_tissue0.82996464
96MP0005584_abnormal_enzyme/coenzyme_acti0.82635206
97MP0000566_synostosis0.81914947
98MP0003436_decreased_susceptibility_to0.81769317
99MP0001730_embryonic_growth_arrest0.81650371
100MP0002697_abnormal_eye_size0.81469147
101MP0000858_altered_metastatic_potential0.81410550
102MP0006138_congestive_heart_failure0.80931781
103MP0001299_abnormal_eye_distance/0.78415862
104MP0008007_abnormal_cellular_replicative0.78350089
105MP0003111_abnormal_nucleus_morphology0.77891908
106MP0010352_gastrointestinal_tract_polyps0.75638133
107MP0005375_adipose_tissue_phenotype0.74963648
108MP0004087_abnormal_muscle_fiber0.74196322
109MP0001243_abnormal_dermal_layer0.73637821
110* MP0005164_abnormal_response_to0.73548895
111MP0004885_abnormal_endolymph0.72454675
112MP0008438_abnormal_cutaneous_collagen0.72286161
113MP0003077_abnormal_cell_cycle0.71882300
114MP0000350_abnormal_cell_proliferation0.71841761
115* MP0000598_abnormal_liver_morphology0.71329415
116MP0003693_abnormal_embryo_hatching0.70250908
117MP0010368_abnormal_lymphatic_system0.69211935
118MP0003984_embryonic_growth_retardation0.69075889
119MP0000647_abnormal_sebaceous_gland0.68590395
120MP0000432_abnormal_head_morphology0.68425406
121MP0006054_spinal_hemorrhage0.68386668
122MP0003755_abnormal_palate_morphology0.67587135
123MP0000604_amyloidosis0.67513826
124MP0002084_abnormal_developmental_patter0.66968372
125MP0003385_abnormal_body_wall0.66556630
126MP0004947_skin_inflammation0.66237564
127MP0000534_abnormal_ureter_morphology0.66177826
128MP0003115_abnormal_respiratory_system0.66167683
129MP0002234_abnormal_pharynx_morphology0.65532686
130MP0000367_abnormal_coat/_hair0.65482390
131MP0001958_emphysema0.65423647
132MP0003724_increased_susceptibility_to0.65087838
133MP0005636_abnormal_mineral_homeostasis0.63398250
134MP0005451_abnormal_body_composition0.62905826
135MP0003303_peritoneal_inflammation0.61063723
136MP0000377_abnormal_hair_follicle0.60898910
137MP0001756_abnormal_urination0.60548520
138MP0008469_abnormal_protein_level0.58295666
139MP0004130_abnormal_muscle_cell0.58219693
140MP0002796_impaired_skin_barrier0.57496733
141* MP0002136_abnormal_kidney_physiology0.55331176
142MP0009763_increased_sensitivity_to0.54768426
143MP0003091_abnormal_cell_migration0.54072521
144MP0002060_abnormal_skin_morphology0.53581773
145MP0005666_abnormal_adipose_tissue0.52893221
146MP0002938_white_spotting0.52135088
147MP0002295_abnormal_pulmonary_circulatio0.51981736
148MP0005464_abnormal_platelet_physiology0.51712915
149MP0004185_abnormal_adipocyte_glucose0.51428035
150MP0005166_decreased_susceptibility_to0.49828901
151MP0009053_abnormal_anal_canal0.49359528
152* MP0005023_abnormal_wound_healing0.48745179
153MP0003075_altered_response_to0.48387518
154MP0002971_abnormal_brown_adipose0.48237163
155MP0002168_other_aberrant_phenotype0.47266482
156MP0005220_abnormal_exocrine_pancreas0.46477331
157MP0002419_abnormal_innate_immunity0.44405573
158MP0005334_abnormal_fat_pad0.44308328
159MP0009642_abnormal_blood_homeostasis0.43844032
160MP0005275_abnormal_skin_tensile0.43808096
161MP0003656_abnormal_erythrocyte_physiolo0.42055735
162MP0001764_abnormal_homeostasis0.41063994
163MP0005167_abnormal_blood-brain_barrier0.41042105
164MP0002998_abnormal_bone_remodeling0.40160660
165MP0006082_CNS_inflammation0.40020513

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)6.28706806
2Aplasia/Hypoplasia affecting the retina (HP:0008061)5.87289381
3Blue irides (HP:0000635)5.86954436
4Deep venous thrombosis (HP:0002625)5.24286569
5Hypoplasia of the fovea (HP:0007750)5.16054873
6Aplasia/Hypoplasia of the fovea (HP:0008060)5.16054873
7Xanthomatosis (HP:0000991)4.95407298
8Intrahepatic cholestasis (HP:0001406)4.94828858
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.46050785
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.43964632
11Atrophic scars (HP:0001075)4.33035855
12Ocular albinism (HP:0001107)4.21274282
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18603891
14Protrusio acetabuli (HP:0003179)4.15302800
15Abnormality of the fovea (HP:0000493)4.10348000
16Prolonged partial thromboplastin time (HP:0003645)4.05967439
17Premature rupture of membranes (HP:0001788)3.96434093
18Short nail (HP:0001799)3.91203415
19Osteolytic defects of the phalanges of the hand (HP:0009771)3.88164509
20Osteolytic defects of the hand bones (HP:0009699)3.88164509
21Hypobetalipoproteinemia (HP:0003563)3.82748984
22Milia (HP:0001056)3.80799981
23Hypopigmentation of the fundus (HP:0007894)3.71358338
24Complement deficiency (HP:0004431)3.65397008
25Epidermoid cyst (HP:0200040)3.52792809
26Bilateral sensorineural hearing impairment (HP:0008619)3.50067571
27Joint hemorrhage (HP:0005261)3.48195644
28Abnormality of the common coagulation pathway (HP:0010990)3.47187403
29Generalized hypopigmentation (HP:0007513)3.46795605
30Onycholysis (HP:0001806)3.46250323
31Iris hypopigmentation (HP:0007730)3.45493725
32Vertebral compression fractures (HP:0002953)3.44734973
33Hyperlipoproteinemia (HP:0010980)3.38738191
34Hypolipoproteinemia (HP:0010981)3.33503850
35Fragile skin (HP:0001030)3.28836436
36Hypoalphalipoproteinemia (HP:0003233)3.28551333
37Right ventricular cardiomyopathy (HP:0011663)3.24318793
38Arterial tortuosity (HP:0005116)3.23997587
39Reduced subcutaneous adipose tissue (HP:0003758)3.17083279
40Spastic diplegia (HP:0001264)3.10774340
41Abnormality of proline metabolism (HP:0010907)3.08191409
42Hydroxyprolinuria (HP:0003080)3.08191409
43Selective tooth agenesis (HP:0001592)3.06398763
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.01601372
45Broad face (HP:0000283)3.01187610
46Congenital sensorineural hearing impairment (HP:0008527)3.00958675
47Fragile nails (HP:0001808)2.96534668
48Ketosis (HP:0001946)2.96427818
49Hyperammonemia (HP:0001987)2.93872477
50Abnormality of complement system (HP:0005339)2.91726916
51White forelock (HP:0002211)2.91521166
52Increased connective tissue (HP:0009025)2.90929523
53Myocardial infarction (HP:0001658)2.89419780
54Distal lower limb amyotrophy (HP:0008944)2.87508173
55Vascular tortuosity (HP:0004948)2.87434212
56Esophageal varix (HP:0002040)2.83336997
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.82656722
58Plantar hyperkeratosis (HP:0007556)2.82137456
59Fat malabsorption (HP:0002630)2.78221852
60* Hepatocellular carcinoma (HP:0001402)2.77537992
61Gout (HP:0001997)2.76533954
62Ulnar bowing (HP:0003031)2.76117250
63Alopecia of scalp (HP:0002293)2.73535968
64Recurrent gram-negative bacterial infections (HP:0005420)2.73458107
65Systemic lupus erythematosus (HP:0002725)2.73416786
66Abnormality of the distal phalanges of the toes (HP:0010182)2.73205575
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72922879
68Hypoplasia of the iris (HP:0007676)2.71878490
69Abnormality of the intrinsic pathway (HP:0010989)2.71862964
70Hyperglycinuria (HP:0003108)2.69714504
71Thick nail (HP:0001805)2.68356741
72Ankyloglossia (HP:0010296)2.67765882
73Cutaneous melanoma (HP:0012056)2.65025376
74Natal tooth (HP:0000695)2.63712237
75Pterygium (HP:0001059)2.62717258
76Abnormality of oral frenula (HP:0000190)2.61406372
77Nail dystrophy (HP:0008404)2.61311573
78Abnormality of purine metabolism (HP:0004352)2.60747826
79Ketoacidosis (HP:0001993)2.59295513
80Hyperacusis (HP:0010780)2.58220724
81Abnormality of serine family amino acid metabolism (HP:0010894)2.57767991
82Abnormality of glycine metabolism (HP:0010895)2.57767991
83Cervical subluxation (HP:0003308)2.57563698
84Patchy hypopigmentation of hair (HP:0011365)2.54290124
85Hypercholesterolemia (HP:0003124)2.53630929
86Wormian bones (HP:0002645)2.49774300
87Hypoglycemic coma (HP:0001325)2.48568763
88Ridged nail (HP:0001807)2.46635094
89Hyperglycinemia (HP:0002154)2.45392002
90Glucose intolerance (HP:0000833)2.44637724
91Focal segmental glomerulosclerosis (HP:0000097)2.44530180
92Abnormality of nucleobase metabolism (HP:0010932)2.43984714
93Generalized hypopigmentation of hair (HP:0011358)2.42275785
94Trismus (HP:0000211)2.40526403
95Abnormality of methionine metabolism (HP:0010901)2.34864526
96Flat acetabular roof (HP:0003180)2.29090813
97Elbow flexion contracture (HP:0002987)2.29009773
98Vascular calcification (HP:0004934)2.27847719
99Skin nodule (HP:0200036)2.27340843
100Urinary glycosaminoglycan excretion (HP:0003541)2.25922414
101Mucopolysacchariduria (HP:0008155)2.25922414
102Abnormality of fatty-acid metabolism (HP:0004359)2.25873221
103Spinal rigidity (HP:0003306)2.24464830
104Aortic dissection (HP:0002647)2.20010513
105Abnormal gallbladder physiology (HP:0012438)2.17383531
106Cholecystitis (HP:0001082)2.17383531
107Achilles tendon contracture (HP:0001771)2.17322894
108Entropion (HP:0000621)2.17235924
109Deviation of the thumb (HP:0009603)2.16693916
110Cardiovascular calcification (HP:0011915)2.11515725
111Distal upper limb amyotrophy (HP:0007149)2.11114740
112Upper limb amyotrophy (HP:0009129)2.11114740
113Abnormality of carpal bone ossification (HP:0006257)2.10901465
114Abnormality of the Achilles tendon (HP:0005109)2.10803538
115Abnormal cartilage morphology (HP:0002763)2.10643849
116Abnormality of pyrimidine metabolism (HP:0004353)2.10458489
117Hypoplasia of dental enamel (HP:0006297)2.09295319
118Glomerulosclerosis (HP:0000096)2.07872045
119Advanced eruption of teeth (HP:0006288)2.05640303
120Abnormality of the acetabulum (HP:0003170)2.05543931
121Interstitial pulmonary disease (HP:0006530)2.05396193
122Ankle contracture (HP:0006466)2.04559917
123Pili torti (HP:0003777)2.04552775
124Distal lower limb muscle weakness (HP:0009053)2.04310291
125Sensorimotor neuropathy (HP:0007141)2.03596234
126Lower limb amyotrophy (HP:0007210)2.03336294
127Spinal cord compression (HP:0002176)2.03281262
128Aortic aneurysm (HP:0004942)2.03149885
129Insomnia (HP:0100785)2.02490552
130Conjugated hyperbilirubinemia (HP:0002908)2.01487952
131Nephritis (HP:0000123)2.01217216
132Abnormality of polysaccharide metabolism (HP:0011012)1.99238340
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99238340
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99238340
135Aplasia cutis congenita (HP:0001057)1.99009564
136Steatorrhea (HP:0002570)1.98695561
137Abnormal ossification of hand bones (HP:0005921)1.98002301
138Spondylolisthesis (HP:0003302)1.94331733
139Glomerulonephritis (HP:0000099)1.94105158
140Abnormal hair laboratory examination (HP:0003328)1.89665724
141Abnormality of the gastric mucosa (HP:0004295)1.89606907
142Vertebral arch anomaly (HP:0008438)1.88847515
143Hyperuricemia (HP:0002149)1.88189459
144Increased purine levels (HP:0004368)1.88189459
145Mildly elevated creatine phosphokinase (HP:0008180)1.87082440
146Amyloidosis (HP:0011034)1.86440637
147Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86192016
148Mitral stenosis (HP:0001718)1.84574891
149Palmoplantar hyperkeratosis (HP:0000972)1.83408992
150Hemorrhage of the eye (HP:0011885)1.81378194
151Tibial bowing (HP:0002982)1.80869435
152Sparse eyelashes (HP:0000653)1.80017299
153Bowing of the arm (HP:0006488)1.79636260
154Bowed forearm bones (HP:0003956)1.79636260
155Syringomyelia (HP:0003396)1.79577090
156Spinal cord lesions (HP:0100561)1.79577090
157Insidious onset (HP:0003587)1.79497300
158Termporal pattern (HP:0011008)1.79497300
159Difficulty climbing stairs (HP:0003551)1.79415095
160Absent frontal sinuses (HP:0002688)1.77482508
161Gingival bleeding (HP:0000225)1.77306336
162Hyperbilirubinemia (HP:0002904)1.77294066
163Menorrhagia (HP:0000132)1.75333721
164Cerebral aneurysm (HP:0004944)1.73735533
165Abnormality of transition element cation homeostasis (HP:0011030)1.73426529
166Palmar hyperkeratosis (HP:0010765)1.72862556
167Tetraparesis (HP:0002273)1.72552648
168Proximal placement of thumb (HP:0009623)1.71662404
169Freckling (HP:0001480)1.71252960
170Coxa vara (HP:0002812)1.70965086
171Albinism (HP:0001022)1.70376953
172Abnormality of iron homeostasis (HP:0011031)1.70153780
173Cerebral inclusion bodies (HP:0100314)1.69772461
174Increased mean platelet volume (HP:0011877)1.69410903
175Abnormality of vision evoked potentials (HP:0000649)1.69215524
176Abnormal glucose tolerance (HP:0001952)1.68134940
177Abnormalities of placenta or umbilical cord (HP:0001194)1.68112856
178Delayed CNS myelination (HP:0002188)1.68084394
179Proximal tubulopathy (HP:0000114)1.67720133
180Shallow orbits (HP:0000586)1.67534088
181Long toe (HP:0010511)1.67351406
182Abnormal enzyme/coenzyme activity (HP:0012379)1.67240106
183Spontaneous abortion (HP:0005268)1.67129431
184Metabolic acidosis (HP:0001942)1.65811012
185Abnormal blistering of the skin (HP:0008066)1.65304660
186Acanthosis nigricans (HP:0000956)1.64923142
187Periodontitis (HP:0000704)1.64756912
188Poikiloderma (HP:0001029)1.64740557
189Abnormality of the nasal septum (HP:0000419)1.61525077
190Mitral regurgitation (HP:0001653)1.61087215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* MST1R6.45846545
2PKN24.21283518
3TRIB33.89806831
4LATS13.28779645
5MARK33.27118758
6FGFR42.88654269
7SIK12.72683721
8ERN12.68658539
9EPHA32.59494919
10FRK2.55030201
11PTK62.21523600
12BCKDK2.19386112
13PBK2.06356580
14EPHA22.04694212
15ERBB42.02480251
16RIPK11.98149982
17TBK11.89479795
18TTN1.78204669
19ICK1.68259937
20EIF2AK11.68167398
21DDR21.65195584
22NEK91.62903906
23SCYL21.61325048
24LRRK21.56931344
25GSK3A1.39656400
26MAP3K141.37455959
27CDK81.34237338
28TYK21.33756525
29ABL21.31283995
30FER1.30216277
31TAOK31.29518696
32FLT31.28537227
33STK391.27679233
34MAP3K121.27165672
35EPHB11.25632936
36NTRK11.24725623
37JAK11.16595646
38BUB11.14900508
39NEK11.14393039
40CAMK1D1.13131128
41CDK61.12950015
42CDK121.10041975
43STK31.08704651
44PTK21.06233057
45TESK11.04874889
46PDGFRA1.03969970
47MAP3K21.03348783
48LIMK10.99372512
49MAP3K90.98577445
50MAP3K30.98155380
51FGFR30.97758075
52WNK40.97328916
53JAK20.96977225
54EIF2AK30.96622622
55STK38L0.95411251
56TRPM70.91666972
57FGFR20.90910167
58MELK0.89445546
59INSRR0.88606399
60BRSK20.85793080
61STK380.84699651
62JAK30.82112774
63EEF2K0.81676994
64RET0.80703569
65MYLK0.80668616
66ERBB20.79528140
67MAP3K100.79182891
68TTK0.78702125
69MAPK110.75784977
70BRSK10.75480758
71* BMX0.75412060
72NUAK10.75236269
73PDGFRB0.72652183
74CSK0.72471691
75MST40.71347161
76TSSK60.70876300
77NME20.68902520
78SMG10.68661311
79MAP3K110.67478658
80PDK20.66588233
81ARAF0.65440574
82PRKG20.65316495
83CHUK0.64986157
84MAP2K10.64031494
85BCR0.63131145
86EGFR0.61734327
87PAK40.61307777
88EPHB20.60764084
89CSNK1G10.60516325
90LATS20.60303102
91RPS6KA40.60094162
92AURKB0.59927853
93TGFBR20.59819181
94WEE10.59247891
95MAP2K30.57493010
96MAP3K10.56339603
97PIK3CG0.55860236
98ERBB30.55800605
99DAPK20.55516906
100KSR20.54554631
101PHKG20.54494846
102PHKG10.54494846
103PRKCI0.54356265
104PDPK10.53945503
105CAMKK10.53761229
106SIK30.53183101
107IRAK30.53173054
108CSNK1A1L0.51411933
109WNK30.51330456
110STK100.50285389
111NEK20.49991290
112PRKAA20.49648532
113PIK3CA0.49339068
114STK240.49211353
115MAP3K80.47611940
116DYRK1B0.47156164
117LMTK20.47142196
118IKBKE0.46541623
119SGK30.45744370
120AKT20.44756437
121RPS6KB20.44527641
122RIPK40.43596814
123BLK0.43500727
124MOS0.43217658
125EIF2AK20.42827087
126MTOR0.42404954
127FGFR10.41061819
128* ABL10.39465710
129PAK20.38809040
130CAMK2G0.38149103
131PIM20.37357238
132ILK0.37203718
133CDK90.35185932
134RPS6KA10.34761554
135CDK70.34591532
136BRAF0.34510421
137PAK30.34469646
138CSNK1G20.34208674
139* MET0.33936899
140CAMK1G0.33564380
141MAP2K40.33161227
142MAP3K50.32290708
143ROCK20.32247082
144KSR10.31965458
145PLK10.31608519
146NEK60.31381145
147AKT30.30387331
148AURKA0.29432852
149MAPKAPK30.28704510
150IRAK20.23867452
151BMPR20.23500621

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.66859373
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17661101
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12858155
4Nitrogen metabolism_Homo sapiens_hsa009103.10969995
5Tyrosine metabolism_Homo sapiens_hsa003503.09259669
6Arginine biosynthesis_Homo sapiens_hsa002202.64184983
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57069219
8Complement and coagulation cascades_Homo sapiens_hsa046102.53477849
9Fatty acid degradation_Homo sapiens_hsa000712.34908265
10Tryptophan metabolism_Homo sapiens_hsa003802.31011672
11* Focal adhesion_Homo sapiens_hsa045102.20917771
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16545479
13* Adherens junction_Homo sapiens_hsa045202.16477633
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15597708
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13181255
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09396690
17* Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.07926738
18Butanoate metabolism_Homo sapiens_hsa006501.96746954
19Staphylococcus aureus infection_Homo sapiens_hsa051501.96477999
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87369767
21PPAR signaling pathway_Homo sapiens_hsa033201.86792920
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83469412
23Peroxisome_Homo sapiens_hsa041461.77907583
24Propanoate metabolism_Homo sapiens_hsa006401.74191993
25Thyroid cancer_Homo sapiens_hsa052161.73396517
26Sulfur metabolism_Homo sapiens_hsa009201.71913970
27Fatty acid metabolism_Homo sapiens_hsa012121.69054615
28Chemical carcinogenesis_Homo sapiens_hsa052041.69019139
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64017556
30Starch and sucrose metabolism_Homo sapiens_hsa005001.63702945
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62501582
32Selenocompound metabolism_Homo sapiens_hsa004501.59982365
33Histidine metabolism_Homo sapiens_hsa003401.58352845
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57050529
35Caffeine metabolism_Homo sapiens_hsa002321.56921463
36Bile secretion_Homo sapiens_hsa049761.55409046
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50403990
38Phenylalanine metabolism_Homo sapiens_hsa003601.43921429
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43904830
40beta-Alanine metabolism_Homo sapiens_hsa004101.43566350
41Vitamin B6 metabolism_Homo sapiens_hsa007501.42685626
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41684625
43Retinol metabolism_Homo sapiens_hsa008301.38738362
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.36093074
45Hippo signaling pathway_Homo sapiens_hsa043901.35333723
46N-Glycan biosynthesis_Homo sapiens_hsa005101.29807111
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27846903
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.26498027
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20924236
50Pancreatic cancer_Homo sapiens_hsa052121.19965471
51Carbon metabolism_Homo sapiens_hsa012001.19297312
52Chronic myeloid leukemia_Homo sapiens_hsa052201.18707467
53Sphingolipid metabolism_Homo sapiens_hsa006001.18592023
54Steroid biosynthesis_Homo sapiens_hsa001001.18398642
55Fat digestion and absorption_Homo sapiens_hsa049751.17400416
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15629749
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14946737
58Other glycan degradation_Homo sapiens_hsa005111.09332839
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08034571
60Dilated cardiomyopathy_Homo sapiens_hsa054141.07008326
61Cell cycle_Homo sapiens_hsa041101.05950408
62Biosynthesis of amino acids_Homo sapiens_hsa012301.05260021
63Pyruvate metabolism_Homo sapiens_hsa006201.04206460
64Tight junction_Homo sapiens_hsa045300.99910579
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98670394
66ABC transporters_Homo sapiens_hsa020100.98542695
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97187629
68* MicroRNAs in cancer_Homo sapiens_hsa052060.96098576
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.95297486
70TGF-beta signaling pathway_Homo sapiens_hsa043500.95000190
71p53 signaling pathway_Homo sapiens_hsa041150.92043741
72Vitamin digestion and absorption_Homo sapiens_hsa049770.91302032
73Shigellosis_Homo sapiens_hsa051310.88798033
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.87600301
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85137370
76Non-homologous end-joining_Homo sapiens_hsa034500.82675388
77Fatty acid biosynthesis_Homo sapiens_hsa000610.82568006
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81102806
79ErbB signaling pathway_Homo sapiens_hsa040120.80705608
80Nucleotide excision repair_Homo sapiens_hsa034200.79300885
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77769013
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.77087421
83Pentose phosphate pathway_Homo sapiens_hsa000300.76797737
84Glutathione metabolism_Homo sapiens_hsa004800.75996153
85* Pathways in cancer_Homo sapiens_hsa052000.74391451
86* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73616341
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72427443
88Galactose metabolism_Homo sapiens_hsa000520.71087947
89Fatty acid elongation_Homo sapiens_hsa000620.70940260
90Thyroid hormone synthesis_Homo sapiens_hsa049180.70759239
91Folate biosynthesis_Homo sapiens_hsa007900.69469829
92Vibrio cholerae infection_Homo sapiens_hsa051100.68508970
93DNA replication_Homo sapiens_hsa030300.68193766
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67962588
95Salmonella infection_Homo sapiens_hsa051320.65548489
96Pyrimidine metabolism_Homo sapiens_hsa002400.65213123
97Circadian rhythm_Homo sapiens_hsa047100.64714595
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64341645
99One carbon pool by folate_Homo sapiens_hsa006700.63627700
100Arginine and proline metabolism_Homo sapiens_hsa003300.62718277
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.62129346
102Lysine degradation_Homo sapiens_hsa003100.61271774
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60468244
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.59810899
105Apoptosis_Homo sapiens_hsa042100.58470558
106Insulin signaling pathway_Homo sapiens_hsa049100.57363826
107Glycerolipid metabolism_Homo sapiens_hsa005610.57197179
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.55596622
109* Renal cell carcinoma_Homo sapiens_hsa052110.55508112
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55494028
111Lysosome_Homo sapiens_hsa041420.55189977
112Glioma_Homo sapiens_hsa052140.54265447
113Non-small cell lung cancer_Homo sapiens_hsa052230.54085923
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53229061
115Insulin resistance_Homo sapiens_hsa049310.52276703
116Proteasome_Homo sapiens_hsa030500.51060679
117Prostate cancer_Homo sapiens_hsa052150.50413008
118* Endocytosis_Homo sapiens_hsa041440.49144164
119RNA transport_Homo sapiens_hsa030130.48853854
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47752539
121Mineral absorption_Homo sapiens_hsa049780.46716902
122Endometrial cancer_Homo sapiens_hsa052130.46178850
123Protein digestion and absorption_Homo sapiens_hsa049740.44443284
124Inositol phosphate metabolism_Homo sapiens_hsa005620.43153649
125Glucagon signaling pathway_Homo sapiens_hsa049220.42913165
126Fructose and mannose metabolism_Homo sapiens_hsa000510.40253667
127Pertussis_Homo sapiens_hsa051330.39978939
128Legionellosis_Homo sapiens_hsa051340.37675350
129Prion diseases_Homo sapiens_hsa050200.35866602
130Sulfur relay system_Homo sapiens_hsa041220.35114180
131Amoebiasis_Homo sapiens_hsa051460.33660342
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28958635
133Phagosome_Homo sapiens_hsa041450.28244836
134TNF signaling pathway_Homo sapiens_hsa046680.27429253
135Metabolic pathways_Homo sapiens_hsa011000.25868322
136Melanogenesis_Homo sapiens_hsa049160.25438733
137Hepatitis C_Homo sapiens_hsa051600.23928989
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22990305
139Small cell lung cancer_Homo sapiens_hsa052220.22839910
140Leishmaniasis_Homo sapiens_hsa051400.20884348
141Osteoclast differentiation_Homo sapiens_hsa043800.18781281
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18764296
143* Central carbon metabolism in cancer_Homo sapiens_hsa052300.18340640
144ECM-receptor interaction_Homo sapiens_hsa045120.17453529
145Tuberculosis_Homo sapiens_hsa051520.16275048
146AMPK signaling pathway_Homo sapiens_hsa041520.16038201
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15167676
148Bladder cancer_Homo sapiens_hsa052190.14054759
149Renin-angiotensin system_Homo sapiens_hsa046140.14034969
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13142974
151* Malaria_Homo sapiens_hsa051440.13036536
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12796590
153Toxoplasmosis_Homo sapiens_hsa051450.12408374
154* Proteoglycans in cancer_Homo sapiens_hsa052050.12109195

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