| 1 | Fibular aplasia (HP:0002990) | 5.91716764 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.37544005 |
| 3 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 4.30835506 |
| 4 | Chromsome breakage (HP:0040012) | 4.26837777 |
| 5 | Asymmetry of the thorax (HP:0001555) | 3.81003327 |
| 6 | Abnormality of the anterior horn cell (HP:0006802) | 3.78384552 |
| 7 | Degeneration of anterior horn cells (HP:0002398) | 3.78384552 |
| 8 | Birth length less than 3rd percentile (HP:0003561) | 3.65851481 |
| 9 | Thoracic kyphosis (HP:0002942) | 3.63919386 |
| 10 | Rough bone trabeculation (HP:0100670) | 3.40487715 |
| 11 | Natal tooth (HP:0000695) | 3.36442836 |
| 12 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.25050045 |
| 13 | Meckel diverticulum (HP:0002245) | 3.24662503 |
| 14 | Multiple enchondromatosis (HP:0005701) | 3.23425939 |
| 15 | Colon cancer (HP:0003003) | 3.19746340 |
| 16 | Embryonal renal neoplasm (HP:0011794) | 3.18668821 |
| 17 | Absent epiphyses (HP:0010577) | 3.16986070 |
| 18 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 3.16986070 |
| 19 | Abnormality of the ileum (HP:0001549) | 3.10820353 |
| 20 | Abnormality of methionine metabolism (HP:0010901) | 3.10685987 |
| 21 | Abnormality of the preputium (HP:0100587) | 3.10484017 |
| 22 | Abnormality of chromosome stability (HP:0003220) | 3.09160245 |
| 23 | Small intestinal stenosis (HP:0012848) | 2.99910571 |
| 24 | Duodenal stenosis (HP:0100867) | 2.99910571 |
| 25 | Abnormal lung lobation (HP:0002101) | 2.93117827 |
| 26 | Selective tooth agenesis (HP:0001592) | 2.91295682 |
| 27 | Hyperglycinemia (HP:0002154) | 2.90545050 |
| 28 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.89777906 |
| 29 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.89121214 |
| 30 | Wrist flexion contracture (HP:0001239) | 2.87705526 |
| 31 | Abnormality of the thoracic spine (HP:0100711) | 2.85059678 |
| 32 | Increased nuchal translucency (HP:0010880) | 2.80677013 |
| 33 | Focal segmental glomerulosclerosis (HP:0000097) | 2.75306465 |
| 34 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.71024503 |
| 35 | Spinal muscular atrophy (HP:0007269) | 2.69098632 |
| 36 | Abnormality of the duodenum (HP:0002246) | 2.61815192 |
| 37 | Short humerus (HP:0005792) | 2.60160822 |
| 38 | Microvesicular hepatic steatosis (HP:0001414) | 2.60100850 |
| 39 | Cellular immunodeficiency (HP:0005374) | 2.58529495 |
| 40 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.58168808 |
| 41 | Breast hypoplasia (HP:0003187) | 2.51300735 |
| 42 | Abnormal trabecular bone morphology (HP:0100671) | 2.49412016 |
| 43 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.46630848 |
| 44 | Ependymoma (HP:0002888) | 2.45812833 |
| 45 | Pelvic girdle muscle weakness (HP:0003749) | 2.43566337 |
| 46 | High pitched voice (HP:0001620) | 2.43452600 |
| 47 | Hypoglycemic seizures (HP:0002173) | 2.41756441 |
| 48 | Increased hepatocellular lipid droplets (HP:0006565) | 2.39444429 |
| 49 | Personality changes (HP:0000751) | 2.39357693 |
| 50 | Biliary tract neoplasm (HP:0100574) | 2.35362584 |
| 51 | Cerebral hypomyelination (HP:0006808) | 2.33733961 |
| 52 | Neoplasm of the colon (HP:0100273) | 2.29211157 |
| 53 | Volvulus (HP:0002580) | 2.28392766 |
| 54 | Glomerulosclerosis (HP:0000096) | 2.28347664 |
| 55 | Absent radius (HP:0003974) | 2.28275216 |
| 56 | Shoulder girdle muscle weakness (HP:0003547) | 2.27582574 |
| 57 | Aplasia/Hypoplasia of the fibula (HP:0006492) | 2.27163325 |
| 58 | Exercise-induced muscle cramps (HP:0003710) | 2.26373761 |
| 59 | Partial agenesis of the corpus callosum (HP:0001338) | 2.26200844 |
| 60 | Angiofibromas (HP:0010615) | 2.25600839 |
| 61 | Adenoma sebaceum (HP:0009720) | 2.25600839 |
| 62 | Trismus (HP:0000211) | 2.21378968 |
| 63 | Abnormality of serum amino acid levels (HP:0003112) | 2.21127298 |
| 64 | Abnormality of the labia minora (HP:0012880) | 2.21077948 |
| 65 | Megaloblastic anemia (HP:0001889) | 2.17695868 |
| 66 | Spastic diplegia (HP:0001264) | 2.17251238 |
| 67 | Thyroid-stimulating hormone excess (HP:0002925) | 2.17103839 |
| 68 | Anal stenosis (HP:0002025) | 2.17086844 |
| 69 | Breast carcinoma (HP:0003002) | 2.16262834 |
| 70 | Agnosia (HP:0010524) | 2.15773944 |
| 71 | Sparse eyelashes (HP:0000653) | 2.14552572 |
| 72 | Neoplasm of the adrenal gland (HP:0100631) | 2.14357705 |
| 73 | Entropion (HP:0000621) | 2.11305985 |
| 74 | Glioma (HP:0009733) | 2.08372628 |
| 75 | Patellar aplasia (HP:0006443) | 2.05850207 |
| 76 | Abnormal spermatogenesis (HP:0008669) | 2.05748929 |
| 77 | Oral leukoplakia (HP:0002745) | 2.03011881 |
| 78 | Absent forearm bone (HP:0003953) | 2.02713532 |
| 79 | Aplasia involving forearm bones (HP:0009822) | 2.02713532 |
| 80 | Horseshoe kidney (HP:0000085) | 2.02270003 |
| 81 | Right ventricular cardiomyopathy (HP:0011663) | 2.02257252 |
| 82 | Abnormality of the calcaneus (HP:0008364) | 2.02177514 |
| 83 | Lipid accumulation in hepatocytes (HP:0006561) | 2.01190702 |
| 84 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.00209851 |
| 85 | Type I transferrin isoform profile (HP:0003642) | 1.99202673 |
| 86 | Medulloblastoma (HP:0002885) | 1.98022916 |
| 87 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.97004510 |
| 88 | Osteolytic defects of the hand bones (HP:0009699) | 1.97004510 |
| 89 | Abnormality of the carotid arteries (HP:0005344) | 1.96725370 |
| 90 | Microretrognathia (HP:0000308) | 1.96567649 |
| 91 | Impulsivity (HP:0100710) | 1.94034081 |
| 92 | Astrocytoma (HP:0009592) | 1.93713087 |
| 93 | Abnormality of the astrocytes (HP:0100707) | 1.93713087 |
| 94 | Rimmed vacuoles (HP:0003805) | 1.93293478 |
| 95 | Microglossia (HP:0000171) | 1.93180583 |
| 96 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.92990937 |
| 97 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.92990937 |
| 98 | Ectopic kidney (HP:0000086) | 1.91836406 |
| 99 | Ovarian neoplasm (HP:0100615) | 1.91808940 |
| 100 | Progressive muscle weakness (HP:0003323) | 1.91033957 |
| 101 | Amniotic constriction ring (HP:0009775) | 1.90754054 |
| 102 | Abnormality of placental membranes (HP:0011409) | 1.90754054 |
| 103 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.90715437 |
| 104 | Increased serum pyruvate (HP:0003542) | 1.89912959 |
| 105 | Abnormality of glycolysis (HP:0004366) | 1.89912959 |
| 106 | Cortical dysplasia (HP:0002539) | 1.89644484 |
| 107 | Stenosis of the external auditory canal (HP:0000402) | 1.89058494 |
| 108 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.89028246 |
| 109 | Embryonal neoplasm (HP:0002898) | 1.88246270 |
| 110 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.88021999 |
| 111 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.88021999 |
| 112 | Abnormal protein glycosylation (HP:0012346) | 1.88021999 |
| 113 | Abnormal glycosylation (HP:0012345) | 1.88021999 |
| 114 | Neoplasm of the adrenal cortex (HP:0100641) | 1.87165439 |
| 115 | Sloping forehead (HP:0000340) | 1.87150675 |
| 116 | Triphalangeal thumb (HP:0001199) | 1.85714835 |
| 117 | Increased serum lactate (HP:0002151) | 1.85519166 |
| 118 | Long foot (HP:0001833) | 1.85281424 |
| 119 | Rhabdomyolysis (HP:0003201) | 1.84975732 |
| 120 | Reticulocytopenia (HP:0001896) | 1.84339031 |
| 121 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.84106786 |
| 122 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.83957958 |
| 123 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.83957958 |
| 124 | Facial cleft (HP:0002006) | 1.83951314 |
| 125 | Choanal atresia (HP:0000453) | 1.83629213 |
| 126 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.83549506 |
| 127 | Nasal speech (HP:0001611) | 1.83403568 |
| 128 | Autoamputation (HP:0001218) | 1.83317127 |
| 129 | Cafe-au-lait spot (HP:0000957) | 1.82401806 |
| 130 | Pterygium (HP:0001059) | 1.82176692 |
| 131 | Bifid tongue (HP:0010297) | 1.81933489 |
| 132 | Acute encephalopathy (HP:0006846) | 1.81891398 |
| 133 | Nuclear cataract (HP:0100018) | 1.80699145 |
| 134 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.80276372 |
| 135 | Gastrointestinal carcinoma (HP:0002672) | 1.80276372 |
| 136 | Reduced antithrombin III activity (HP:0001976) | 1.80081518 |
| 137 | Carpal bone hypoplasia (HP:0001498) | 1.79923641 |
| 138 | Palpitations (HP:0001962) | 1.79915936 |
| 139 | Limb hypertonia (HP:0002509) | 1.79894819 |
| 140 | Global brain atrophy (HP:0002283) | 1.77932953 |
| 141 | Symptomatic seizures (HP:0011145) | 1.77464322 |
| 142 | Proximal placement of thumb (HP:0009623) | 1.77337284 |
| 143 | Zonular cataract (HP:0010920) | 1.77000717 |
| 144 | Increased density of long bones (HP:0006392) | 1.76996662 |
| 145 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.75695593 |
| 146 | Increased connective tissue (HP:0009025) | 1.75606160 |
| 147 | Deviation of the thumb (HP:0009603) | 1.74511038 |
| 148 | Abnormal biliary tract morphology (HP:0012440) | 1.74463057 |
| 149 | Abnormality of the umbilical cord (HP:0010881) | 1.74269419 |
| 150 | Neoplasm of the pancreas (HP:0002894) | 1.73638054 |
| 151 | Abnormality of the pons (HP:0007361) | 1.72102941 |
| 152 | Postnatal microcephaly (HP:0005484) | 1.71802227 |
| 153 | Uterine neoplasm (HP:0010784) | 1.71577574 |
| 154 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.70309811 |
| 155 | Abnormality of glycine metabolism (HP:0010895) | 1.70309811 |
| 156 | Thrombocytosis (HP:0001894) | 1.70196836 |
| 157 | Basal cell carcinoma (HP:0002671) | 1.69769485 |
| 158 | Areflexia of lower limbs (HP:0002522) | 1.69503322 |
| 159 | Hypobetalipoproteinemia (HP:0003563) | 1.69267427 |
| 160 | Prominent metopic ridge (HP:0005487) | 1.69257615 |
| 161 | Rhabdomyosarcoma (HP:0002859) | 1.68394026 |
| 162 | Hypoplasia of the pons (HP:0012110) | 1.67816614 |
| 163 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.67684662 |
| 164 | Distal arthrogryposis (HP:0005684) | 1.67378389 |
| 165 | Fused cervical vertebrae (HP:0002949) | 1.67273867 |
| 166 | Myelodysplasia (HP:0002863) | 1.67255409 |
| 167 | Hyperglycinuria (HP:0003108) | 1.66853697 |
| 168 | Delayed closure of the anterior fontanelle (HP:0001476) | 1.66546039 |
| 169 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.66407114 |
| 170 | Squamous cell carcinoma (HP:0002860) | 1.65539186 |
METAP1 
