METAP1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.71883939
2L-phenylalanine catabolic process (GO:0006559)5.71883939
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.14885360
4L-phenylalanine metabolic process (GO:0006558)5.14885360
5aromatic amino acid family catabolic process (GO:0009074)4.80795324
6ribosomal small subunit assembly (GO:0000028)4.46496852
7transcription from mitochondrial promoter (GO:0006390)4.32348837
8ethanol oxidation (GO:0006069)4.25834292
9tryptophan catabolic process (GO:0006569)4.16824814
10indole-containing compound catabolic process (GO:0042436)4.16824814
11indolalkylamine catabolic process (GO:0046218)4.16824814
12branched-chain amino acid catabolic process (GO:0009083)4.00658704
13tryptophan metabolic process (GO:0006568)3.95711107
14valine metabolic process (GO:0006573)3.92576828
15daunorubicin metabolic process (GO:0044597)3.91419374
16polyketide metabolic process (GO:0030638)3.91419374
17doxorubicin metabolic process (GO:0044598)3.91419374
18mitochondrial RNA metabolic process (GO:0000959)3.87365654
19bile acid biosynthetic process (GO:0006699)3.83579522
20cysteine metabolic process (GO:0006534)3.82103822
21L-serine metabolic process (GO:0006563)3.77299873
22cellular biogenic amine catabolic process (GO:0042402)3.74279515
23amine catabolic process (GO:0009310)3.74279515
24regulation of mitochondrial translation (GO:0070129)3.70428355
25oxidative phosphorylation (GO:0006119)3.69765753
26pseudouridine synthesis (GO:0001522)3.69585635
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67411045
28high-density lipoprotein particle remodeling (GO:0034375)3.67078900
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.64554021
30purine ribonucleotide transport (GO:0015868)3.61803626
31homocysteine metabolic process (GO:0050667)3.60253316
32short-chain fatty acid metabolic process (GO:0046459)3.59225264
33sulfur amino acid catabolic process (GO:0000098)3.56139645
34bile acid metabolic process (GO:0008206)3.54386862
35branched-chain amino acid metabolic process (GO:0009081)3.54375249
36coenzyme catabolic process (GO:0009109)3.53911052
37kinetochore assembly (GO:0051382)3.52961165
38alpha-amino acid catabolic process (GO:1901606)3.51319789
39water-soluble vitamin biosynthetic process (GO:0042364)3.43573953
40ubiquinone metabolic process (GO:0006743)3.43081466
41replication fork processing (GO:0031297)3.42286379
42histone H2A acetylation (GO:0043968)3.40507004
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37782930
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.37782930
45NADH dehydrogenase complex assembly (GO:0010257)3.37782930
46glyoxylate metabolic process (GO:0046487)3.35974670
47serine family amino acid biosynthetic process (GO:0009070)3.34659469
48fatty acid elongation (GO:0030497)3.33225607
49kinetochore organization (GO:0051383)3.31826499
50very long-chain fatty acid metabolic process (GO:0000038)3.31197119
51alpha-linolenic acid metabolic process (GO:0036109)3.31098510
52very-low-density lipoprotein particle assembly (GO:0034379)3.29123709
53kynurenine metabolic process (GO:0070189)3.29084188
54amino-acid betaine metabolic process (GO:0006577)3.29005613
55tRNA aminoacylation (GO:0043039)3.28032876
56amino acid activation (GO:0043038)3.28032876
57reverse cholesterol transport (GO:0043691)3.27582548
58tRNA aminoacylation for protein translation (GO:0006418)3.27494975
59cellular amino acid catabolic process (GO:0009063)3.25702862
60formation of translation preinitiation complex (GO:0001731)3.25647539
61DNA damage response, detection of DNA damage (GO:0042769)3.25227786
62cofactor catabolic process (GO:0051187)3.24033608
63aromatic amino acid family metabolic process (GO:0009072)3.23335390
64NAD biosynthetic process (GO:0009435)3.21413506
65rRNA modification (GO:0000154)3.21131353
66carnitine metabolic process (GO:0009437)3.19630342
67purine nucleotide transport (GO:0015865)3.17852970
68ribosome assembly (GO:0042255)3.17597444
69low-density lipoprotein particle remodeling (GO:0034374)3.16460333
70fatty acid beta-oxidation (GO:0006635)3.16248428
71nucleobase biosynthetic process (GO:0046112)3.15432649
72organic acid catabolic process (GO:0016054)3.13422553
73carboxylic acid catabolic process (GO:0046395)3.13422553
74base-excision repair, AP site formation (GO:0006285)3.12733956
75lipid oxidation (GO:0034440)3.12535806
76tRNA metabolic process (GO:0006399)3.12001129
77protein-lipid complex remodeling (GO:0034368)3.11878114
78macromolecular complex remodeling (GO:0034367)3.11878114
79plasma lipoprotein particle remodeling (GO:0034369)3.11878114
80serine family amino acid catabolic process (GO:0009071)3.11581075
81fatty acid oxidation (GO:0019395)3.10751412
82peptidyl-histidine modification (GO:0018202)3.10387715
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09384997
84fatty acid catabolic process (GO:0009062)3.09110911
85monocarboxylic acid catabolic process (GO:0072329)3.08237616
86blood coagulation, intrinsic pathway (GO:0007597)3.07703977
87aspartate family amino acid catabolic process (GO:0009068)3.07049843
88tyrosine metabolic process (GO:0006570)3.04900614
89negative regulation of RNA splicing (GO:0033119)3.04427368
90indolalkylamine metabolic process (GO:0006586)3.03824150
91proteasome assembly (GO:0043248)3.03508348
92protein-cofactor linkage (GO:0018065)3.03432850
93imidazole-containing compound metabolic process (GO:0052803)3.02485430
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02437052
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02437052
96signal peptide processing (GO:0006465)3.01781899
97ribosome biogenesis (GO:0042254)3.01544161
98termination of RNA polymerase II transcription (GO:0006369)3.00773726
99rRNA catabolic process (GO:0016075)3.00625990
100protein complex biogenesis (GO:0070271)3.00563159
101negative regulation of lipase activity (GO:0060192)2.99693634
102DNA catabolic process, exonucleolytic (GO:0000738)2.98642295
103lysine metabolic process (GO:0006553)2.98114396
104lysine catabolic process (GO:0006554)2.98114396
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98052203
106DNA double-strand break processing (GO:0000729)2.97442640
107tRNA processing (GO:0008033)2.96405692
108spliceosomal snRNP assembly (GO:0000387)2.96340258
109viral mRNA export from host cell nucleus (GO:0046784)2.96087644
110regulation of translational fidelity (GO:0006450)2.95465175
111IMP biosynthetic process (GO:0006188)2.95373367
112mismatch repair (GO:0006298)2.95233692
113metallo-sulfur cluster assembly (GO:0031163)2.95083909
114iron-sulfur cluster assembly (GO:0016226)2.95083909
115tRNA modification (GO:0006400)2.93630443
116cellular modified amino acid catabolic process (GO:0042219)2.92804734
117pyridine nucleotide biosynthetic process (GO:0019363)2.92767011
118nicotinamide nucleotide biosynthetic process (GO:0019359)2.92767011
119postreplication repair (GO:0006301)2.92199425
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92052699
121serine family amino acid metabolic process (GO:0009069)2.89228755
122purine nucleobase biosynthetic process (GO:0009113)2.88525663
123maturation of 5.8S rRNA (GO:0000460)2.87521881
124pyrimidine nucleotide catabolic process (GO:0006244)2.85813628
125DNA strand renaturation (GO:0000733)2.84847360
126protoporphyrinogen IX biosynthetic process (GO:0006782)2.84807061
127positive regulation of cellular amine metabolic process (GO:0033240)2.84523609
128rRNA metabolic process (GO:0016072)2.84298799
129DNA-templated transcription, termination (GO:0006353)2.84113858
130regulation of cholesterol esterification (GO:0010872)2.83878919
131NAD metabolic process (GO:0019674)2.83526412
132peptidyl-glutamic acid carboxylation (GO:0017187)2.82820329
133protein carboxylation (GO:0018214)2.82820329
134double-strand break repair via homologous recombination (GO:0000724)2.82765182
135rRNA processing (GO:0006364)2.82433831
136translesion synthesis (GO:0019985)2.81643244
137respiratory chain complex IV assembly (GO:0008535)2.81324627
138phospholipid efflux (GO:0033700)2.81023105
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80876386
140positive regulation of megakaryocyte differentiation (GO:0045654)2.80827172
141primary alcohol catabolic process (GO:0034310)2.80641658
142ncRNA metabolic process (GO:0034660)2.79826445
143cellular component biogenesis (GO:0044085)2.79735193
144recombinational repair (GO:0000725)2.79353526
145regulation of bile acid biosynthetic process (GO:0070857)2.79080464
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78912269
147negative regulation of mRNA processing (GO:0050686)2.78790477
148ribosomal large subunit biogenesis (GO:0042273)2.78196517
149rRNA methylation (GO:0031167)2.78143886
150biotin metabolic process (GO:0006768)2.77815617
151ubiquinone biosynthetic process (GO:0006744)2.77754369
152quinone biosynthetic process (GO:1901663)2.77754369
153ethanol metabolic process (GO:0006067)2.77227051
154positive regulation of granulocyte differentiation (GO:0030854)2.76474902
155mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.76462257
156cytochrome complex assembly (GO:0017004)2.75510875
157reciprocal DNA recombination (GO:0035825)2.75241355
158reciprocal meiotic recombination (GO:0007131)2.75241355
159transcription elongation from RNA polymerase III promoter (GO:0006385)2.75001866
160termination of RNA polymerase III transcription (GO:0006386)2.75001866
161termination of RNA polymerase I transcription (GO:0006363)2.74557855
162energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74161901
163ATP synthesis coupled proton transport (GO:0015986)2.74161901
164plasma lipoprotein particle assembly (GO:0034377)2.72816693
165maturation of SSU-rRNA (GO:0030490)2.72699620
166plasma lipoprotein particle organization (GO:0071827)2.72660997
167ncRNA processing (GO:0034470)2.72415174
168mitochondrial respiratory chain complex assembly (GO:0033108)2.72287776
169mannosylation (GO:0097502)2.72040492
170cellular ketone body metabolic process (GO:0046950)2.71226724
171linoleic acid metabolic process (GO:0043651)2.71050108
172nucleotide transport (GO:0006862)2.70408680
173DNA ligation (GO:0006266)2.69909527
174small molecule catabolic process (GO:0044282)2.69636219
175nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69354622
176regulation of cilium movement (GO:0003352)2.69256655
177somatic hypermutation of immunoglobulin genes (GO:0016446)2.68881137
178somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68881137
179folic acid-containing compound biosynthetic process (GO:0009396)2.68126161
180cholesterol efflux (GO:0033344)2.67969683
181telomere maintenance via recombination (GO:0000722)2.66486367
182RNA export from nucleus (GO:0006405)2.66179270
183quinone metabolic process (GO:1901661)2.66019000
184mitotic recombination (GO:0006312)2.64299296
185ribonucleoprotein complex biogenesis (GO:0022613)2.64163673
186cullin deneddylation (GO:0010388)2.63721553
187protoporphyrinogen IX metabolic process (GO:0046501)2.62320085
188exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62185986
189adenine nucleotide transport (GO:0051503)2.61184031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.71371544
2E2F7_22180533_ChIP-Seq_HELA_Human4.80923003
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.47585679
4GATA1_22025678_ChIP-Seq_K562_Human3.99984752
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.87443491
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.74671724
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.71792069
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.49171217
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.29967478
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.28744256
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23629525
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.13313017
13GBX2_23144817_ChIP-Seq_PC3_Human3.03890296
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91856257
15ZNF274_21170338_ChIP-Seq_K562_Hela2.90752030
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86440832
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81827954
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.81091406
19VDR_23849224_ChIP-Seq_CD4+_Human2.78129988
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.71910677
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71214352
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.68161119
23FOXP3_21729870_ChIP-Seq_TREG_Human2.62039035
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58211118
25ELK1_19687146_ChIP-ChIP_HELA_Human2.53877260
26SCL_19346495_ChIP-Seq_HPC-7_Human2.52558296
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49892786
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41892794
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35833570
30* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29793524
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29492793
32GABP_19822575_ChIP-Seq_HepG2_Human2.24061134
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.24025152
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.23135557
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22184465
36HTT_18923047_ChIP-ChIP_STHdh_Human2.21890258
37DCP1A_22483619_ChIP-Seq_HELA_Human2.19674339
38TTF2_22483619_ChIP-Seq_HELA_Human2.17253235
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14798218
40IGF1R_20145208_ChIP-Seq_DFB_Human2.11787276
41IRF1_19129219_ChIP-ChIP_H3396_Human2.10108542
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05944024
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02583675
44XRN2_22483619_ChIP-Seq_HELA_Human1.97960911
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97682554
46CIITA_25753668_ChIP-Seq_RAJI_Human1.94687137
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92985781
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89817470
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86821264
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86741898
51MYC_18940864_ChIP-ChIP_HL60_Human1.85643347
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.84734380
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80747204
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78597858
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74603704
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73649669
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.72266173
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72230683
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68915244
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64127440
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61697474
62TAF15_26573619_Chip-Seq_HEK293_Human1.61557808
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.57283874
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57152574
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56058049
66KDM5A_27292631_Chip-Seq_BREAST_Human1.52846905
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52615390
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.48777063
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48259802
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.42592087
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.41141726
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40832078
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40605896
74FUS_26573619_Chip-Seq_HEK293_Human1.38486259
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37886260
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35950266
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35306695
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35187495
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35173160
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34242107
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34166559
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33471221
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.32549812
84AR_20517297_ChIP-Seq_VCAP_Human1.31950701
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30701120
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.27588600
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27314764
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25802923
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24893080
90VDR_22108803_ChIP-Seq_LS180_Human1.24296348
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.23462768
92EWS_26573619_Chip-Seq_HEK293_Human1.23263754
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23126724
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22051631
95SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20775613
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.20451981
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.20405693
98P53_22387025_ChIP-Seq_ESCs_Mouse1.20245792
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19893779
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18402725
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18248525
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17161036
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.16480977
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16151194
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.16116930
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15048137
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14038571
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13972647
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13651224
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11824555
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11785725
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11774967
113P300_18555785_Chip-Seq_ESCs_Mouse1.11733779
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11677583
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11660360
116P300_19829295_ChIP-Seq_ESCs_Human1.11231391
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.11073795
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.10616592
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10265382
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10089496
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07946197
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07091489
123ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06285757
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.06255320
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.06125729
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05840086
127ER_23166858_ChIP-Seq_MCF-7_Human1.05154314
128PU1_27457419_Chip-Seq_LIVER_Mouse1.04530842
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.04273732
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04041942
131CTCF_18555785_Chip-Seq_ESCs_Mouse1.02414803
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01634439
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01478999
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01115040
135KLF4_18555785_Chip-Seq_ESCs_Mouse1.00986249
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00307568
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00081177
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.97919391
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.97910056
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96571850
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95639046
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94608695
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93057368
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92799356
145ZNF263_19887448_ChIP-Seq_K562_Human0.91900513
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91810580
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91764847
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.91458102
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90281547
150TP53_22573176_ChIP-Seq_HFKS_Human0.89463213
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88254604
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.88237422
153SOX2_19829295_ChIP-Seq_ESCs_Human0.86917531
154NANOG_19829295_ChIP-Seq_ESCs_Human0.86917531
155MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85842758
156EZH2_22144423_ChIP-Seq_EOC_Human0.85756155
157CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84599374
158THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84172770
159TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83478080
160SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81697233
161FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81541035
162PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81460957
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81315906
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80839279
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80747478
166HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79800260
167FOXM1_23109430_ChIP-Seq_U2OS_Human0.75752545
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.74772644
169* FOXP1_21924763_ChIP-Seq_HESCs_Human0.71579605
170MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.67694848
171DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67030385
172SOX17_20123909_ChIP-Seq_XEN_Mouse0.66837833
173TFEB_21752829_ChIP-Seq_HELA_Human0.65582745
174TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64196815
175NANOG_16153702_ChIP-ChIP_HESCs_Human0.64099090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.88578756
2MP0003806_abnormal_nucleotide_metabolis4.78411805
3MP0005365_abnormal_bile_salt4.37235855
4MP0005360_urolithiasis4.03645561
5MP0008058_abnormal_DNA_repair4.01128526
6MP0005085_abnormal_gallbladder_physiolo3.79908024
7MP0008875_abnormal_xenobiotic_pharmacok3.68199866
8MP0010094_abnormal_chromosome_stability3.24003468
9MP0008789_abnormal_olfactory_epithelium3.05071583
10MP0005409_darkened_coat_color2.81236907
11MP0003693_abnormal_embryo_hatching2.72253684
12MP0003656_abnormal_erythrocyte_physiolo2.66267686
13MP0001986_abnormal_taste_sensitivity2.65751675
14MP0003111_abnormal_nucleus_morphology2.64995972
15MP0005646_abnormal_pituitary_gland2.61096322
16MP0004147_increased_porphyrin_level2.48610997
17MP0009697_abnormal_copulation2.40878805
18MP0001764_abnormal_homeostasis2.30164440
19MP0003868_abnormal_feces_composition2.27468974
20MP0003011_delayed_dark_adaptation2.22511024
21MP0003252_abnormal_bile_duct2.17968733
22MP0005332_abnormal_amino_acid2.12575101
23MP0003195_calcinosis2.11480149
24MP0003786_premature_aging2.06364734
25MP0005394_taste/olfaction_phenotype1.99860861
26MP0005499_abnormal_olfactory_system1.99860861
27MP0006036_abnormal_mitochondrial_physio1.99147953
28MP0002876_abnormal_thyroid_physiology1.98892388
29MP0006292_abnormal_olfactory_placode1.97802573
30MP0010329_abnormal_lipoprotein_level1.97659231
31MP0004957_abnormal_blastocyst_morpholog1.94657902
32MP0001529_abnormal_vocalization1.94266291
33MP0005367_renal/urinary_system_phenotyp1.90567065
34MP0000516_abnormal_urinary_system1.90567065
35MP0005551_abnormal_eye_electrophysiolog1.89406570
36MP0001666_abnormal_nutrient_absorption1.84333649
37MP0002234_abnormal_pharynx_morphology1.78045789
38MP0003718_maternal_effect1.77872457
39MP0003077_abnormal_cell_cycle1.73869089
40MP0005670_abnormal_white_adipose1.71604779
41MP0003567_abnormal_fetal_cardiomyocyte1.61200761
42MP0003385_abnormal_body_wall1.59960995
43MP0004019_abnormal_vitamin_homeostasis1.57872176
44MP0002118_abnormal_lipid_homeostasis1.51870050
45MP0008007_abnormal_cellular_replicative1.51098259
46MP0005584_abnormal_enzyme/coenzyme_acti1.50351547
47MP0008932_abnormal_embryonic_tissue1.48654191
48MP0000372_irregular_coat_pigmentation1.47671802
49MP0008877_abnormal_DNA_methylation1.44379087
50MP0002160_abnormal_reproductive_system1.44060587
51MP0005075_abnormal_melanosome_morpholog1.42670388
52MP0008995_early_reproductive_senescence1.39878917
53MP0009379_abnormal_foot_pigmentation1.39702620
54MP0009840_abnormal_foam_cell1.38856559
55MP0003186_abnormal_redox_activity1.38316825
56MP0001188_hyperpigmentation1.37490557
57MP0001661_extended_life_span1.37091638
58MP0003183_abnormal_peptide_metabolism1.37029879
59MP0001929_abnormal_gametogenesis1.32750194
60MP0005220_abnormal_exocrine_pancreas1.30860046
61MP0001293_anophthalmia1.28453161
62MP0002233_abnormal_nose_morphology1.24230775
63MP0005319_abnormal_enzyme/_coenzyme1.23953409
64MP0003698_abnormal_male_reproductive1.22633312
65MP0003172_abnormal_lysosome_physiology1.20600527
66MP0001145_abnormal_male_reproductive1.19026621
67MP0000653_abnormal_sex_gland1.18985628
68MP0003690_abnormal_glial_cell1.18170226
69MP0002210_abnormal_sex_determination1.16142268
70MP0001502_abnormal_circadian_rhythm1.14730552
71MP0002638_abnormal_pupillary_reflex1.13533152
72MP0000049_abnormal_middle_ear1.13343540
73MP0004142_abnormal_muscle_tone1.13160812
74MP0004043_abnormal_pH_regulation1.10658185
75MP0005058_abnormal_lysosome_morphology1.10518065
76MP0004130_abnormal_muscle_cell1.09923250
77MP0000631_abnormal_neuroendocrine_gland1.09179275
78MP0003122_maternal_imprinting1.08853047
79MP0003937_abnormal_limbs/digits/tail_de1.08787403
80MP0009765_abnormal_xenobiotic_induced1.08753070
81MP0005174_abnormal_tail_pigmentation1.08749580
82MP0003315_abnormal_perineum_morphology1.08227702
83MP0000609_abnormal_liver_physiology1.07068512
84MP0009764_decreased_sensitivity_to1.04921741
85MP0005451_abnormal_body_composition1.04849213
86MP0002396_abnormal_hematopoietic_system1.02882057
87MP0004215_abnormal_myocardial_fiber1.02285475
88MP0005084_abnormal_gallbladder_morpholo1.01559814
89MP0005636_abnormal_mineral_homeostasis1.00004271
90MP0001485_abnormal_pinna_reflex0.99945792
91MP0002102_abnormal_ear_morphology0.99385998
92MP0004145_abnormal_muscle_electrophysio0.99225029
93MP0004197_abnormal_fetal_growth/weight/0.98370656
94MP0003121_genomic_imprinting0.96900797
95MP0009384_cardiac_valve_regurgitation0.96585873
96MP0005253_abnormal_eye_physiology0.95787773
97MP0009763_increased_sensitivity_to0.95429394
98MP0002736_abnormal_nociception_after0.95212651
99MP0004885_abnormal_endolymph0.94818133
100MP0006035_abnormal_mitochondrial_morpho0.94289443
101MP0000358_abnormal_cell_content/0.93468896
102MP0002132_abnormal_respiratory_system0.92755308
103MP0000749_muscle_degeneration0.92238247
104MP0005645_abnormal_hypothalamus_physiol0.91747656
105MP0001697_abnormal_embryo_size0.91182958
106MP0002282_abnormal_trachea_morphology0.90814441
107MP0001270_distended_abdomen0.89841517
108MP0008260_abnormal_autophagy0.89522429
109MP0004381_abnormal_hair_follicle0.89088165
110MP0001984_abnormal_olfaction0.89034040
111MP0000313_abnormal_cell_death0.87254382
112MP0002822_catalepsy0.87244986
113MP0009643_abnormal_urine_homeostasis0.87204285
114MP0005171_absent_coat_pigmentation0.86809459
115MP0005397_hematopoietic_system_phenotyp0.86505713
116MP0001545_abnormal_hematopoietic_system0.86505713
117MP0002111_abnormal_tail_morphology0.86139685
118MP0005379_endocrine/exocrine_gland_phen0.85456801
119MP0001968_abnormal_touch/_nociception0.85096340
120MP0004185_abnormal_adipocyte_glucose0.84694976
121MP0009780_abnormal_chondrocyte_physiolo0.83750680
122MP0005647_abnormal_sex_gland0.83236389
123MP0001853_heart_inflammation0.82694710
124MP0009703_decreased_birth_body0.80841650
125MP0002229_neurodegeneration0.80612983
126MP0002095_abnormal_skin_pigmentation0.80049959
127MP0000920_abnormal_myelination0.79929709
128MP0002938_white_spotting0.78303642
129MP0005464_abnormal_platelet_physiology0.77981237
130MP0000350_abnormal_cell_proliferation0.77860257
131MP0003938_abnormal_ear_development0.77695618
132MP0001672_abnormal_embryogenesis/_devel0.76437036
133MP0005380_embryogenesis_phenotype0.76437036
134MP0002080_prenatal_lethality0.76323707
135MP0000465_gastrointestinal_hemorrhage0.76301274
136MP0000015_abnormal_ear_pigmentation0.76153323
137MP0003136_yellow_coat_color0.75313137
138MP0002078_abnormal_glucose_homeostasis0.75277896
139MP0000230_abnormal_systemic_arterial0.75040016
140MP0002019_abnormal_tumor_incidence0.74962613
141MP0009642_abnormal_blood_homeostasis0.74798881
142MP0003191_abnormal_cellular_cholesterol0.74673858
143MP0001905_abnormal_dopamine_level0.73001391
144MP0001119_abnormal_female_reproductive0.72559352
145MP0003950_abnormal_plasma_membrane0.71965580
146MP0004134_abnormal_chest_morphology0.71745809
147MP0008872_abnormal_physiological_respon0.70823504
148MP0008469_abnormal_protein_level0.70622899
149MP0005376_homeostasis/metabolism_phenot0.70320567
150MP0001324_abnormal_eye_pigmentation0.69894042
151MP0002751_abnormal_autonomic_nervous0.69481082
152MP0002084_abnormal_developmental_patter0.68871516
153MP0000566_synostosis0.67943072
154MP0004133_heterotaxia0.67801045
155MP0005389_reproductive_system_phenotype0.67627936
156MP0008775_abnormal_heart_ventricle0.67012347
157MP0005083_abnormal_biliary_tract0.66996583
158MP0003755_abnormal_palate_morphology0.66700852
159MP0002114_abnormal_axial_skeleton0.66145918
160MP0003646_muscle_fatigue0.65269042
161MP0010030_abnormal_orbit_morphology0.65227889
162MP0003943_abnormal_hepatobiliary_system0.63858123
163MP0001486_abnormal_startle_reflex0.63606626
164MP0005595_abnormal_vascular_smooth0.62757768
165MP0003724_increased_susceptibility_to0.62554301
166MP0003137_abnormal_impulse_conducting0.62446935
167MP0000681_abnormal_thyroid_gland0.61596477
168MP0002089_abnormal_postnatal_growth/wei0.61536899
169MP0000678_abnormal_parathyroid_gland0.60772098
170MP0003953_abnormal_hormone_level0.59582913
171MP0002272_abnormal_nervous_system0.58450560
172MP0006072_abnormal_retinal_apoptosis0.58378862

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41999895
2Intrahepatic cholestasis (HP:0001406)4.40320242
33-Methylglutaconic aciduria (HP:0003535)4.10029336
4Prolonged partial thromboplastin time (HP:0003645)4.06403087
5Abnormality of fatty-acid metabolism (HP:0004359)3.50426855
6Hyperglycinemia (HP:0002154)3.48512400
7Hyperlipoproteinemia (HP:0010980)3.45133469
8Increased hepatocellular lipid droplets (HP:0006565)3.44086936
9Abnormal number of erythroid precursors (HP:0012131)3.41948028
10Microvesicular hepatic steatosis (HP:0001414)3.38524263
11Abnormality of methionine metabolism (HP:0010901)3.35747095
12Lipid accumulation in hepatocytes (HP:0006561)3.28352909
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20097193
14Dicarboxylic aciduria (HP:0003215)3.20097193
15Chromsome breakage (HP:0040012)3.19240094
16Generalized aminoaciduria (HP:0002909)3.14155320
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13689880
18Colon cancer (HP:0003003)3.06576843
19Renal cortical cysts (HP:0000803)3.04791192
20Reduced antithrombin III activity (HP:0001976)3.03960515
21Abnormality of cells of the erythroid lineage (HP:0012130)3.02047994
22Abnormality of glycine metabolism (HP:0010895)3.01714326
23Abnormality of serine family amino acid metabolism (HP:0010894)3.01714326
24Hepatic necrosis (HP:0002605)2.98300866
25Hyperglycinuria (HP:0003108)2.93399747
26Ketosis (HP:0001946)2.92770620
27Abnormality of midbrain morphology (HP:0002418)2.91986024
28Molar tooth sign on MRI (HP:0002419)2.91986024
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.90084186
30Abnormality of serum amino acid levels (HP:0003112)2.90044785
31Hyperammonemia (HP:0001987)2.84803276
32Chronic hepatic failure (HP:0100626)2.83440444
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.83128794
34Increased intramyocellular lipid droplets (HP:0012240)2.82762512
35Acute necrotizing encephalopathy (HP:0006965)2.82257521
36Hepatocellular necrosis (HP:0001404)2.81577141
37Conjugated hyperbilirubinemia (HP:0002908)2.79304209
38Hyperbilirubinemia (HP:0002904)2.74689130
39Medial flaring of the eyebrow (HP:0010747)2.74511062
40Joint hemorrhage (HP:0005261)2.69824029
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.67963382
42Xanthomatosis (HP:0000991)2.63797598
43Increased serum pyruvate (HP:0003542)2.62639321
44Thyroid-stimulating hormone excess (HP:0002925)2.62349236
45Methylmalonic aciduria (HP:0012120)2.58809975
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58080109
47Methylmalonic acidemia (HP:0002912)2.56704566
48Hypobetalipoproteinemia (HP:0003563)2.56502386
49Metabolic acidosis (HP:0001942)2.55435407
50Abnormal biliary tract physiology (HP:0012439)2.51500516
51Bile duct proliferation (HP:0001408)2.51500516
52Fat malabsorption (HP:0002630)2.51281402
53Nephronophthisis (HP:0000090)2.48628527
54Congenital primary aphakia (HP:0007707)2.46892260
55Type I transferrin isoform profile (HP:0003642)2.46718774
56Abnormality of the axillary hair (HP:0100134)2.46265994
57Abnormality of secondary sexual hair (HP:0009888)2.46265994
58Abnormality of DNA repair (HP:0003254)2.42410749
59Hypoglycemic coma (HP:0001325)2.42178179
60Dry hair (HP:0011359)2.41029238
61Increased muscle lipid content (HP:0009058)2.40533856
62Ketoacidosis (HP:0001993)2.40189692
63Abnormality of the ileum (HP:0001549)2.38292790
64Gait imbalance (HP:0002141)2.37527011
65Ragged-red muscle fibers (HP:0003200)2.34923949
66Congenital stationary night blindness (HP:0007642)2.33880544
67Meckel diverticulum (HP:0002245)2.33529342
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33370544
69Abnormal protein N-linked glycosylation (HP:0012347)2.33370544
70Abnormal protein glycosylation (HP:0012346)2.33370544
71Abnormal glycosylation (HP:0012345)2.33370544
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33158481
73Progressive macrocephaly (HP:0004481)2.32175583
74Cerebral palsy (HP:0100021)2.30559626
75Short tibia (HP:0005736)2.29698914
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29670785
77Nephrogenic diabetes insipidus (HP:0009806)2.28492975
78Pancreatic cysts (HP:0001737)2.27629029
79Lactic acidosis (HP:0003128)2.26868010
80Steatorrhea (HP:0002570)2.26522222
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26275477
82Abnormality of alanine metabolism (HP:0010916)2.26275477
83Hyperalaninemia (HP:0003348)2.26275477
84Acute lymphatic leukemia (HP:0006721)2.25995029
85Abnormality of the intrinsic pathway (HP:0010989)2.23149518
86True hermaphroditism (HP:0010459)2.23051481
87Pendular nystagmus (HP:0012043)2.20925021
88Abnormality of glycolysis (HP:0004366)2.20805771
89Lethargy (HP:0001254)2.20260063
90Tubulointerstitial nephritis (HP:0001970)2.19970456
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18851481
92Proximal tubulopathy (HP:0000114)2.17982111
93Acute encephalopathy (HP:0006846)2.17740171
94Type II lissencephaly (HP:0007260)2.17417858
95Homocystinuria (HP:0002156)2.15028558
96Abnormality of homocysteine metabolism (HP:0010919)2.15028558
97Hypolipoproteinemia (HP:0010981)2.14230284
98Hypoplasia of the thymus (HP:0000778)2.14172788
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.14118439
100Renal Fanconi syndrome (HP:0001994)2.11174009
101Birth length less than 3rd percentile (HP:0003561)2.10826004
102Pancreatic fibrosis (HP:0100732)2.10032557
103Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09866139
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09866139
105Acanthocytosis (HP:0001927)2.09495962
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08856343
107Symptomatic seizures (HP:0011145)2.08815463
108Cerebral edema (HP:0002181)2.08452402
109Abnormal rod and cone electroretinograms (HP:0008323)2.07044838
110Hypoalphalipoproteinemia (HP:0003233)2.06950043
111Aplasia/Hypoplasia of the tibia (HP:0005772)2.04946667
112Abnormality of the preputium (HP:0100587)2.03495718
113Pancytopenia (HP:0001876)2.03395587
114Abnormality of the renal cortex (HP:0011035)2.03244187
115Opisthotonus (HP:0002179)2.03119443
116Enlarged kidneys (HP:0000105)2.01366294
117Prolonged bleeding time (HP:0003010)2.01171902
118Deep venous thrombosis (HP:0002625)2.00820997
119Elevated hepatic transaminases (HP:0002910)2.00376902
120Hypoglycemic seizures (HP:0002173)1.99572449
121Exercise intolerance (HP:0003546)1.98445048
122Hyperventilation (HP:0002883)1.96074887
123Hypergonadotropic hypogonadism (HP:0000815)1.95431380
124Retinal dysplasia (HP:0007973)1.94441605
125Increased serum lactate (HP:0002151)1.91781689
126Abnormality of the renal medulla (HP:0100957)1.91666846
127Increased CSF lactate (HP:0002490)1.91528923
128Myelodysplasia (HP:0002863)1.90430267
129Epidermoid cyst (HP:0200040)1.89337950
130Abnormality of chromosome stability (HP:0003220)1.88285796
131Abolished electroretinogram (ERG) (HP:0000550)1.87906595
132Cerebral hypomyelination (HP:0006808)1.87230541
133Pancreatic islet-cell hyperplasia (HP:0004510)1.86270960
134Abnormality of pyrimidine metabolism (HP:0004353)1.86037581
135Progressive microcephaly (HP:0000253)1.84755592
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84169586
137Spontaneous abortion (HP:0005268)1.83936802
138Vomiting (HP:0002013)1.82819140
139Abnormal mitochondria in muscle tissue (HP:0008316)1.80884082
140Tented upper lip vermilion (HP:0010804)1.80781817
141Scanning speech (HP:0002168)1.80329670
142Mitochondrial inheritance (HP:0001427)1.79712117
143Triphalangeal thumb (HP:0001199)1.79508498
144Postaxial foot polydactyly (HP:0001830)1.78996670
145CNS hypomyelination (HP:0003429)1.78842346
146Patchy hypopigmentation of hair (HP:0011365)1.78712512
147Hypercholesterolemia (HP:0003124)1.78069665
148Aganglionic megacolon (HP:0002251)1.77426139
149Abnormality of vitamin metabolism (HP:0100508)1.76906192
150Abnormality of the renal collecting system (HP:0004742)1.76414219
151Hypothermia (HP:0002045)1.76100284
152Attenuation of retinal blood vessels (HP:0007843)1.75527260
153Macrocytic anemia (HP:0001972)1.75010608
154Genital tract atresia (HP:0001827)1.74621808
155Cerebellar dysplasia (HP:0007033)1.74382397
156Lissencephaly (HP:0001339)1.74279419
157Prominent nasal bridge (HP:0000426)1.72820931
158Hypoplasia of the pons (HP:0012110)1.70342871
159Pallor (HP:0000980)1.68588893
160Sloping forehead (HP:0000340)1.68215207
161Abnormality of the vitamin B12 metabolism (HP:0004341)1.67782194
162Respiratory difficulties (HP:0002880)1.67619048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K26.14177870
2TNIK5.96220263
3MUSK4.50214410
4CASK3.72267524
5BCKDK3.54840503
6VRK23.22158625
7NME12.76353064
8INSRR2.67492605
9STK162.60239814
10PLK42.51132304
11MAP3K41.98463148
12SIK11.97610853
13PINK11.89668475
14SIK31.86495026
15FLT31.70539273
16KIT1.69699954
17PRPF4B1.67904722
18TESK21.61679434
19PBK1.61140903
20IRAK31.60869821
21NEK11.59418510
22CDC71.53939841
23ADRBK21.47532183
24MAP2K71.45356874
25EIF2AK31.44011406
26MAPKAPK51.43612658
27SCYL21.43521539
28TAOK31.43419666
29SGK21.41449451
30MKNK21.38294803
31EIF2AK11.37209014
32LATS11.35759003
33TXK1.32179286
34BRSK21.32030157
35CSNK1G31.29937562
36BUB11.29119237
37SRPK11.27487673
38MAP2K31.27101194
39RPS6KA41.26397858
40SGK31.25359648
41TEC1.21808924
42NTRK31.20160054
43MAPK151.19741188
44ATR1.17965495
45DYRK21.16747871
46MAP3K141.16542388
47NME21.16236960
48SGK2231.15360141
49SGK4941.15360141
50CHEK21.13548639
51CSNK1G11.13074963
52WNK41.08038753
53NLK1.07771643
54NUAK11.07736836
55MAP3K71.06365707
56CSNK1A1L1.05932043
57ZAK1.04973529
58CSNK1G21.04528096
59ERBB31.04469246
60TTK1.03326589
61EIF2AK21.02673533
62CDK30.97342928
63VRK10.97242214
64OXSR10.97085814
65PLK10.96795681
66YES10.96760536
67CDK190.95059268
68BTK0.94288323
69MAPK70.93777473
70MKNK10.93570275
71MAPK120.93055667
72GRK70.92678235
73PHKG20.90390359
74PHKG10.90390359
75MAP4K10.88487804
76BMPR1B0.87991229
77PLK30.87587098
78TNK20.86712436
79TAOK20.85280003
80MAPK110.84021594
81OBSCN0.83521036
82PRKAA20.83468973
83ATM0.82570392
84TAF10.81766756
85CAMK10.80744903
86CSF1R0.78998054
87RAF10.78636958
88FRK0.78426822
89CDK70.76833866
90TRIM280.76772567
91HIPK20.75936046
92PIK3CA0.74825406
93BRD40.72122908
94IKBKE0.71803219
95MAP2K60.70891856
96CAMKK20.69085641
97IRAK40.68708020
98TSSK60.68662613
99CHEK10.67550882
100AURKB0.66887202
101PASK0.66770665
102NEK20.65914488
103TIE10.65254348
104PIK3CG0.64665740
105GRK10.62436892
106CSNK2A20.62199127
107EPHA40.62086442
108SIK20.57733555
109RPS6KB10.55558417
110CSNK1E0.54664249
111PIM20.54361567
112MARK10.54132354
113MARK20.53777609
114MAPK130.53706826
115CDK20.51374936
116PRKCE0.51137684
117STK38L0.49680055
118CDK10.49484616
119MAP3K50.48725473
120LYN0.48325249
121TGFBR20.48231216
122CSNK2A10.47880214
123CDK80.47013609
124MAP2K40.46516931
125PRKAA10.46128797
126CAMK2G0.45650179
127CCNB10.44630076
128WNK30.43776433
129PRKDC0.42257120
130CAMK40.41065463
131MAPK40.40874589
132RPS6KA50.40834722
133TRPM70.40240067
134MST40.40160058
135FGFR40.39692868
136DYRK30.38885412
137IKBKB0.38746232
138ERBB40.38413307
139DAPK10.38211909
140CLK10.38123473
141CAMK2D0.37752736
142RPS6KB20.37059254
143SYK0.37028670
144MAP3K60.36848987
145IRAK10.35904007
146PRKG10.34975427
147STK390.34629363
148CDK40.34151957
149RPS6KA60.33954429
150TLK10.33275548
151PRKACA0.33209903
152PRKCQ0.33079417
153AURKA0.32825079
154TBK10.32249097
155FGFR30.32031895
156STK30.30748863
157RPS6KC10.30039861
158RPS6KL10.30039861
159MAPK30.29668125
160PRKACB0.29043246
161WEE10.24947619
162PLK20.24681721

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.23227342
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.01748609
3DNA replication_Homo sapiens_hsa030302.93939220
4RNA polymerase_Homo sapiens_hsa030202.92566199
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.84127664
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82716064
7Base excision repair_Homo sapiens_hsa034102.81252317
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73835959
9Fatty acid degradation_Homo sapiens_hsa000712.72663709
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66760139
11Fatty acid elongation_Homo sapiens_hsa000622.63680756
12Propanoate metabolism_Homo sapiens_hsa006402.61033230
13Spliceosome_Homo sapiens_hsa030402.55977556
14Peroxisome_Homo sapiens_hsa041462.36399447
15RNA transport_Homo sapiens_hsa030132.25742939
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23250783
17Basal transcription factors_Homo sapiens_hsa030222.23234864
18Nucleotide excision repair_Homo sapiens_hsa034202.22031979
19Proteasome_Homo sapiens_hsa030502.21729248
20Steroid biosynthesis_Homo sapiens_hsa001002.09995116
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01327796
22Sulfur relay system_Homo sapiens_hsa041221.98079377
23Fatty acid metabolism_Homo sapiens_hsa012121.97077377
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.96356640
25Caffeine metabolism_Homo sapiens_hsa002321.92655502
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86982713
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.84052822
28Folate biosynthesis_Homo sapiens_hsa007901.83729975
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81906072
30Chemical carcinogenesis_Homo sapiens_hsa052041.79953402
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79822142
32Histidine metabolism_Homo sapiens_hsa003401.79292196
33beta-Alanine metabolism_Homo sapiens_hsa004101.76642101
34Protein export_Homo sapiens_hsa030601.75363541
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.75135486
36Tryptophan metabolism_Homo sapiens_hsa003801.74149957
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73663531
38Butanoate metabolism_Homo sapiens_hsa006501.72435371
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70191066
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67813817
41RNA degradation_Homo sapiens_hsa030181.66556423
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.64878750
43Retinol metabolism_Homo sapiens_hsa008301.62474591
44Sulfur metabolism_Homo sapiens_hsa009201.62458753
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.55491013
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51188167
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50976198
48Complement and coagulation cascades_Homo sapiens_hsa046101.50195660
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49795490
50Selenocompound metabolism_Homo sapiens_hsa004501.45551452
51ABC transporters_Homo sapiens_hsa020101.41508991
52Pyruvate metabolism_Homo sapiens_hsa006201.37071147
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.36093289
54Arginine biosynthesis_Homo sapiens_hsa002201.33411242
55PPAR signaling pathway_Homo sapiens_hsa033201.32065562
56Vitamin digestion and absorption_Homo sapiens_hsa049771.31217504
57Tyrosine metabolism_Homo sapiens_hsa003501.24651032
58Arginine and proline metabolism_Homo sapiens_hsa003301.23688033
59Huntingtons disease_Homo sapiens_hsa050161.20652726
60mRNA surveillance pathway_Homo sapiens_hsa030151.20155897
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19300167
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11819927
63Starch and sucrose metabolism_Homo sapiens_hsa005001.05250180
64Phototransduction_Homo sapiens_hsa047441.03905488
65One carbon pool by folate_Homo sapiens_hsa006700.99786693
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99244826
67Cell cycle_Homo sapiens_hsa041100.97648188
68Phenylalanine metabolism_Homo sapiens_hsa003600.96752008
69Carbon metabolism_Homo sapiens_hsa012000.91333062
70Metabolic pathways_Homo sapiens_hsa011000.89450104
71Biosynthesis of amino acids_Homo sapiens_hsa012300.88881003
72N-Glycan biosynthesis_Homo sapiens_hsa005100.85727310
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84105213
74Nitrogen metabolism_Homo sapiens_hsa009100.80093329
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76783445
76Circadian rhythm_Homo sapiens_hsa047100.75273674
77Lysine degradation_Homo sapiens_hsa003100.74633523
78Bile secretion_Homo sapiens_hsa049760.73093476
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72629235
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70178491
81Vitamin B6 metabolism_Homo sapiens_hsa007500.69341077
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67099678
83Other glycan degradation_Homo sapiens_hsa005110.65161109
84Non-homologous end-joining_Homo sapiens_hsa034500.64931252
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63580107
86Fatty acid biosynthesis_Homo sapiens_hsa000610.60943570
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60570131
88Linoleic acid metabolism_Homo sapiens_hsa005910.56791218
89Pentose phosphate pathway_Homo sapiens_hsa000300.54957911
90Glutathione metabolism_Homo sapiens_hsa004800.54256811
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50992407
92Homologous recombination_Homo sapiens_hsa034400.50700975
93Fructose and mannose metabolism_Homo sapiens_hsa000510.50239943
94Glycerolipid metabolism_Homo sapiens_hsa005610.48740474
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45767519
96Oxidative phosphorylation_Homo sapiens_hsa001900.45692806
97p53 signaling pathway_Homo sapiens_hsa041150.44741515
98Regulation of autophagy_Homo sapiens_hsa041400.42419159
99Ether lipid metabolism_Homo sapiens_hsa005650.41918684
100Pyrimidine metabolism_Homo sapiens_hsa002400.40723495
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40561967
102Staphylococcus aureus infection_Homo sapiens_hsa051500.39447572
103Sphingolipid metabolism_Homo sapiens_hsa006000.38988653
104Olfactory transduction_Homo sapiens_hsa047400.36598116
105Oocyte meiosis_Homo sapiens_hsa041140.34226346
106Taste transduction_Homo sapiens_hsa047420.34067273
107Arachidonic acid metabolism_Homo sapiens_hsa005900.33879771
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33830059
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33698715
110Fat digestion and absorption_Homo sapiens_hsa049750.32151373
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31929970
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.31183045
113Fanconi anemia pathway_Homo sapiens_hsa034600.28834108
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28195814
115Insulin secretion_Homo sapiens_hsa049110.26325492
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25722511
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.25436468
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24916496
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24690812
120Alzheimers disease_Homo sapiens_hsa050100.24613423
121Mismatch repair_Homo sapiens_hsa034300.23160449
122Parkinsons disease_Homo sapiens_hsa050120.22674118
123Primary immunodeficiency_Homo sapiens_hsa053400.21150306
124Purine metabolism_Homo sapiens_hsa002300.21039919
125Galactose metabolism_Homo sapiens_hsa000520.20496327
126Hematopoietic cell lineage_Homo sapiens_hsa046400.20229519
127Epstein-Barr virus infection_Homo sapiens_hsa051690.18312557
128Ribosome_Homo sapiens_hsa030100.17347583
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17197126
130Ovarian steroidogenesis_Homo sapiens_hsa049130.16796474
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.16785159

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