METAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.37922301
2establishment of integrated proviral latency (GO:0075713)4.33194880
3mitotic metaphase plate congression (GO:0007080)4.30579343
4DNA replication checkpoint (GO:0000076)4.10427084
5DNA replication initiation (GO:0006270)4.10181083
6DNA strand elongation involved in DNA replication (GO:0006271)4.08111791
7mitotic sister chromatid cohesion (GO:0007064)4.08098202
8proteasome assembly (GO:0043248)4.05166135
9purine nucleobase biosynthetic process (GO:0009113)4.03669155
10nucleobase biosynthetic process (GO:0046112)4.02246115
11DNA strand elongation (GO:0022616)3.98374848
12CENP-A containing nucleosome assembly (GO:0034080)3.97116173
13formation of translation preinitiation complex (GO:0001731)3.96296492
14ribosomal small subunit assembly (GO:0000028)3.92460059
15nuclear pore complex assembly (GO:0051292)3.88839731
16ribosome assembly (GO:0042255)3.87803991
17ribosomal large subunit biogenesis (GO:0042273)3.86666203
18chromatin remodeling at centromere (GO:0031055)3.86055572
19telomere maintenance via semi-conservative replication (GO:0032201)3.85760881
20ribosomal small subunit biogenesis (GO:0042274)3.81643737
21ribonucleoprotein complex biogenesis (GO:0022613)3.77856709
22ribosome biogenesis (GO:0042254)3.77825998
23translational termination (GO:0006415)3.76489568
24viral transcription (GO:0019083)3.76444279
25protein localization to kinetochore (GO:0034501)3.73579038
26mitotic chromosome condensation (GO:0007076)3.72991117
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.64810887
28termination of RNA polymerase III transcription (GO:0006386)3.64810887
29regulation of DNA endoreduplication (GO:0032875)3.62769427
30DNA replication-independent nucleosome organization (GO:0034724)3.62377598
31DNA replication-independent nucleosome assembly (GO:0006336)3.62377598
32metaphase plate congression (GO:0051310)3.62255340
33sister chromatid segregation (GO:0000819)3.61024854
34kinetochore organization (GO:0051383)3.59703479
35translational initiation (GO:0006413)3.59604102
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58932028
37IMP biosynthetic process (GO:0006188)3.56920288
38rRNA processing (GO:0006364)3.55492861
39DNA topological change (GO:0006265)3.54697830
40spliceosomal snRNP assembly (GO:0000387)3.53437932
41DNA unwinding involved in DNA replication (GO:0006268)3.53124048
42telomere maintenance via recombination (GO:0000722)3.51528808
43regulation of spindle organization (GO:0090224)3.51258355
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49810142
45rRNA modification (GO:0000154)3.49804643
46DNA deamination (GO:0045006)3.49096334
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48871654
48regulation of centriole replication (GO:0046599)3.46975826
49rRNA metabolic process (GO:0016072)3.46401570
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45338725
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.44419208
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44101705
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43556342
54DNA ligation (GO:0006266)3.42857980
55histone exchange (GO:0043486)3.40719463
56translational elongation (GO:0006414)3.39953972
577-methylguanosine mRNA capping (GO:0006370)3.39885764
58cotranslational protein targeting to membrane (GO:0006613)3.38859947
59mitotic recombination (GO:0006312)3.38163555
60protein localization to chromosome, centromeric region (GO:0071459)3.36015904
61attachment of spindle microtubules to kinetochore (GO:0008608)3.36012944
627-methylguanosine RNA capping (GO:0009452)3.35860914
63RNA capping (GO:0036260)3.35860914
64protein targeting to ER (GO:0045047)3.35681665
65DNA double-strand break processing (GO:0000729)3.35114810
66mitotic nuclear envelope disassembly (GO:0007077)3.34126725
67kinetochore assembly (GO:0051382)3.31874275
68transcription elongation from RNA polymerase I promoter (GO:0006362)3.30255645
69DNA replication-dependent nucleosome organization (GO:0034723)3.28919478
70DNA replication-dependent nucleosome assembly (GO:0006335)3.28919478
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28801275
72telomere maintenance via telomere lengthening (GO:0010833)3.24230548
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24142082
74transcription-coupled nucleotide-excision repair (GO:0006283)3.22775562
75negative regulation of ligase activity (GO:0051352)3.22599792
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22599792
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.20813160
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20447726
79termination of RNA polymerase I transcription (GO:0006363)3.20080425
80protein localization to endoplasmic reticulum (GO:0070972)3.19140933
81pseudouridine synthesis (GO:0001522)3.18259422
82ATP-dependent chromatin remodeling (GO:0043044)3.16427091
83spindle checkpoint (GO:0031577)3.15515095
84spliceosomal complex assembly (GO:0000245)3.14702105
85establishment of viral latency (GO:0019043)3.14350866
86IMP metabolic process (GO:0046040)3.13143502
87mitotic sister chromatid segregation (GO:0000070)3.13027455
88translation (GO:0006412)3.13007872
89establishment of chromosome localization (GO:0051303)3.12949513
90regulation of helicase activity (GO:0051095)3.12376977
91folic acid-containing compound biosynthetic process (GO:0009396)3.11654047
92non-recombinational repair (GO:0000726)3.11143076
93double-strand break repair via nonhomologous end joining (GO:0006303)3.11143076
94transcription from RNA polymerase I promoter (GO:0006360)3.08934606
95maturation of 5.8S rRNA (GO:0000460)3.08533112
96nuclear envelope disassembly (GO:0051081)3.07972055
97membrane disassembly (GO:0030397)3.07972055
98cellular protein complex disassembly (GO:0043624)3.06075796
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05679900
100G1/S transition of mitotic cell cycle (GO:0000082)3.05477814
101cell cycle G1/S phase transition (GO:0044843)3.05477814
102nucleotide-excision repair, DNA gap filling (GO:0006297)3.03974722
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02663566
104termination of RNA polymerase II transcription (GO:0006369)3.02589272
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.02305829
106positive regulation of chromosome segregation (GO:0051984)3.01823105
107mitotic spindle checkpoint (GO:0071174)3.01571198
108negative regulation of mitotic sister chromatid separation (GO:2000816)3.01300430
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01300430
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01300430
111negative regulation of sister chromatid segregation (GO:0033046)3.01300430
112nuclear pore organization (GO:0006999)3.01214403
113cellular component biogenesis (GO:0044085)2.99715881
114viral life cycle (GO:0019058)2.99625762
115spindle assembly checkpoint (GO:0071173)2.98484790
116negative regulation of chromosome segregation (GO:0051985)2.98473345
117mitotic spindle assembly checkpoint (GO:0007094)2.98242097
118viral mRNA export from host cell nucleus (GO:0046784)2.98087385
119regulation of chromosome segregation (GO:0051983)2.97977483
120rRNA methylation (GO:0031167)2.96344923
121transcription elongation from RNA polymerase II promoter (GO:0006368)2.95837423
122positive regulation of ligase activity (GO:0051351)2.95448886
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93550933
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93550933
125regulation of centrosome cycle (GO:0046605)2.92412239
126DNA catabolic process, exonucleolytic (GO:0000738)2.92130545
127chromatin assembly or disassembly (GO:0006333)2.91201663
128pore complex assembly (GO:0046931)2.89883818
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89541075
130regulation of mitotic spindle checkpoint (GO:1903504)2.89541075
131DNA damage response, detection of DNA damage (GO:0042769)2.89533627
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87044399
133negative regulation of RNA splicing (GO:0033119)2.87001382
134regulation of mitotic sister chromatid separation (GO:0010965)2.86467319
135regulation of mitotic sister chromatid segregation (GO:0033047)2.86467319
136regulation of sister chromatid segregation (GO:0033045)2.86467319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48997452
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.52210141
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96078617
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83347899
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70421977
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.58953781
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.57807982
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.51267227
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.30952187
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29595182
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24877503
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21177942
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05922068
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96777749
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94560892
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70892472
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59709064
18VDR_23849224_ChIP-Seq_CD4+_Human2.55398288
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51615791
20XRN2_22483619_ChIP-Seq_HELA_Human2.44064070
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42242186
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40885179
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38483104
24AR_21909140_ChIP-Seq_LNCAP_Human2.37931255
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33464244
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28618809
27DCP1A_22483619_ChIP-Seq_HELA_Human2.23962205
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12209401
29ELK1_19687146_ChIP-ChIP_HELA_Human2.12106693
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10904228
31FOXP3_21729870_ChIP-Seq_TREG_Human2.10374002
32GABP_19822575_ChIP-Seq_HepG2_Human2.08654892
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08556729
34TTF2_22483619_ChIP-Seq_HELA_Human2.05499254
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02795174
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01833153
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99643499
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.98181243
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97386658
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89369189
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84818727
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84283679
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82557663
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70237767
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.66375333
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66122917
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61121087
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59557611
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.57891693
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56720249
51KDM5A_27292631_Chip-Seq_BREAST_Human1.52558824
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50873900
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47589047
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47350013
55EWS_26573619_Chip-Seq_HEK293_Human1.47173141
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45965354
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45573125
58CIITA_25753668_ChIP-Seq_RAJI_Human1.42922537
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33168380
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.32155837
61FUS_26573619_Chip-Seq_HEK293_Human1.32114004
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30754953
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26605571
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25121910
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23615790
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.18445790
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.15026026
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12138016
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11659682
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11197322
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08917702
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08734976
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08088466
74MYC_18940864_ChIP-ChIP_HL60_Human1.07584435
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07066926
76TFEB_21752829_ChIP-Seq_HELA_Human1.06253839
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.04196910
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03729741
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03099615
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00959714
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00575025
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.98131928
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95326252
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94904713
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94839758
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94633810
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92449637
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90550386
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90252275
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89693811
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86550199
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.86354103
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85050891
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84464128
95MYC_22102868_ChIP-Seq_BL_Human0.81999148
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80336199
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78582181
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78582181
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78582181
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77849928
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76987782
102* CHD1_26751641_Chip-Seq_LNCaP_Human0.75804139
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75603642
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75363906
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74254454
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72950472
107* SPI1_23547873_ChIP-Seq_NB4_Human0.72839318
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72003423
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.71747551
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71423196
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.71398359
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70710428
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70569537
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70258271
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.69645557
116VDR_22108803_ChIP-Seq_LS180_Human0.68712665
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68498371
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64203517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67429727
2MP0010094_abnormal_chromosome_stability4.49811052
3MP0003111_abnormal_nucleus_morphology4.46867324
4MP0004957_abnormal_blastocyst_morpholog4.36022024
5MP0008057_abnormal_DNA_replication3.84111618
6MP0003077_abnormal_cell_cycle3.76706263
7MP0008058_abnormal_DNA_repair3.19608964
8MP0008007_abnormal_cellular_replicative3.04621254
9MP0008932_abnormal_embryonic_tissue2.84600799
10MP0003786_premature_aging2.41201856
11MP0008877_abnormal_DNA_methylation2.35215285
12MP0003123_paternal_imprinting2.35146925
13MP0009697_abnormal_copulation2.24956498
14* MP0001730_embryonic_growth_arrest2.18321325
15MP0002396_abnormal_hematopoietic_system2.07128533
16* MP0000350_abnormal_cell_proliferation2.01399986
17MP0003718_maternal_effect1.89334204
18MP0004147_increased_porphyrin_level1.83263041
19MP0003656_abnormal_erythrocyte_physiolo1.72803011
20MP0005380_embryogenesis_phenotype1.60549049
21MP0001672_abnormal_embryogenesis/_devel1.60549049
22* MP0001697_abnormal_embryo_size1.60181669
23MP0000490_abnormal_crypts_of1.54107478
24* MP0002080_prenatal_lethality1.48878327
25MP0003984_embryonic_growth_retardation1.46103318
26MP0002697_abnormal_eye_size1.44866882
27MP0002210_abnormal_sex_determination1.43244656
28MP0003567_abnormal_fetal_cardiomyocyte1.43185995
29MP0002088_abnormal_embryonic_growth/wei1.41982255
30MP0010352_gastrointestinal_tract_polyps1.38737672
31* MP0002085_abnormal_embryonic_tissue1.37419884
32MP0009333_abnormal_splenocyte_physiolog1.35554323
33MP0003315_abnormal_perineum_morphology1.35309458
34* MP0000313_abnormal_cell_death1.34539283
35MP0005397_hematopoietic_system_phenotyp1.26874749
36MP0001545_abnormal_hematopoietic_system1.26874749
37MP0010307_abnormal_tumor_latency1.26455739
38MP0002234_abnormal_pharynx_morphology1.24677991
39MP0004808_abnormal_hematopoietic_stem1.24470745
40MP0002938_white_spotting1.24433986
41MP0001145_abnormal_male_reproductive1.23699595
42MP0003119_abnormal_digestive_system1.23225365
43MP0002132_abnormal_respiratory_system1.22778199
44MP0006072_abnormal_retinal_apoptosis1.22550577
45* MP0002084_abnormal_developmental_patter1.21488738
46MP0002233_abnormal_nose_morphology1.19094190
47MP0003121_genomic_imprinting1.17843228
48MP0009379_abnormal_foot_pigmentation1.17431272
49MP0008260_abnormal_autophagy1.16962710
50MP0003941_abnormal_skin_development1.16207276
51MP0010030_abnormal_orbit_morphology1.16033733
52MP0005394_taste/olfaction_phenotype1.12207162
53MP0005499_abnormal_olfactory_system1.12207162
54MP0001929_abnormal_gametogenesis1.10396864
55MP0002160_abnormal_reproductive_system1.09829273
56MP0000653_abnormal_sex_gland1.09295089
57MP0004197_abnormal_fetal_growth/weight/1.08775350
58MP0000049_abnormal_middle_ear1.08557091
59MP0002102_abnormal_ear_morphology1.07131659
60MP0002019_abnormal_tumor_incidence1.06676122
61MP0002086_abnormal_extraembryonic_tissu1.06441051
62MP0003937_abnormal_limbs/digits/tail_de1.04969281
63MP0003385_abnormal_body_wall1.02337660
64MP0002092_abnormal_eye_morphology1.01435567
65MP0001293_anophthalmia1.00148501
66MP0006054_spinal_hemorrhage0.98323703
67MP0001529_abnormal_vocalization0.97552922
68MP0002163_abnormal_gland_morphology0.97383378
69MP0003221_abnormal_cardiomyocyte_apopto0.97224753
70MP0008789_abnormal_olfactory_epithelium0.93949549
71MP0006292_abnormal_olfactory_placode0.92887738
72MP0005187_abnormal_penis_morphology0.91197509
73MP0001188_hyperpigmentation0.91158557
74MP0000762_abnormal_tongue_morphology0.90839801
75MP0000358_abnormal_cell_content/0.90208526
76MP0006036_abnormal_mitochondrial_physio0.89036270
77MP0002095_abnormal_skin_pigmentation0.88869627
78MP0000750_abnormal_muscle_regeneration0.87347690
79MP0003186_abnormal_redox_activity0.86993753
80MP0003878_abnormal_ear_physiology0.85996077
81MP0005377_hearing/vestibular/ear_phenot0.85996077
82MP0003861_abnormal_nervous_system0.85739576
83MP0000647_abnormal_sebaceous_gland0.84086824
84MP0005389_reproductive_system_phenotype0.83508908
85MP0001299_abnormal_eye_distance/0.81599019
86MP0000631_abnormal_neuroendocrine_gland0.80241048
87MP0003935_abnormal_craniofacial_develop0.79970177
88MP0005391_vision/eye_phenotype0.78475627
89MP0003890_abnormal_embryonic-extraembry0.78217612
90MP0000566_synostosis0.76268511
91MP0009672_abnormal_birth_weight0.75156122
92MP0001346_abnormal_lacrimal_gland0.74643960
93MP0009250_abnormal_appendicular_skeleto0.73542034
94MP0005384_cellular_phenotype0.71146298
95MP0001542_abnormal_bone_strength0.70618351
96MP0001119_abnormal_female_reproductive0.70314867
97MP0004133_heterotaxia0.69764864
98MP0000428_abnormal_craniofacial_morphol0.69571663
99MP0003938_abnormal_ear_development0.69507908
100MP0003806_abnormal_nucleotide_metabolis0.69479161
101MP0003942_abnormal_urinary_system0.68644342
102MP0003136_yellow_coat_color0.68160856
103MP0002877_abnormal_melanocyte_morpholog0.67373499
104MP0001727_abnormal_embryo_implantation0.67239826
105MP0000703_abnormal_thymus_morphology0.66699616
106MP0001986_abnormal_taste_sensitivity0.66545693
107MP0002751_abnormal_autonomic_nervous0.66389589
108MP0003943_abnormal_hepatobiliary_system0.65869482
109MP0001286_abnormal_eye_development0.65072475
110MP0002111_abnormal_tail_morphology0.65041161
111MP0006035_abnormal_mitochondrial_morpho0.63148565
112MP0009703_decreased_birth_body0.62028323
113MP0000537_abnormal_urethra_morphology0.61909578
114MP0005621_abnormal_cell_physiology0.61403228
115MP0002653_abnormal_ependyma_morphology0.61169049
116MP0000372_irregular_coat_pigmentation0.59292302
117MP0009053_abnormal_anal_canal0.58800870
118MP0008995_early_reproductive_senescence0.58608536
119MP0005408_hypopigmentation0.58585534
120MP0003950_abnormal_plasma_membrane0.58343213
121MP0003698_abnormal_male_reproductive0.58283240
122MP0000432_abnormal_head_morphology0.57874154
123MP0003755_abnormal_palate_morphology0.55115630
124MP0002722_abnormal_immune_system0.54838364
125MP0002114_abnormal_axial_skeleton0.54410858
126MP0005501_abnormal_skin_physiology0.53504130

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.36180735
2Abnormality of cells of the erythroid lineage (HP:0012130)4.66212036
3Abnormal number of erythroid precursors (HP:0012131)4.52822954
4Breast hypoplasia (HP:0003187)4.11454724
5Reticulocytopenia (HP:0001896)3.90000063
6Rough bone trabeculation (HP:0100670)3.55529450
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.55185395
8Cerebral hypomyelination (HP:0006808)3.40448236
9Patellar aplasia (HP:0006443)3.31502967
10Aplastic anemia (HP:0001915)3.26272006
11Volvulus (HP:0002580)3.22090294
12Carpal bone hypoplasia (HP:0001498)3.19996555
13Aplasia/Hypoplasia of the patella (HP:0006498)3.15771437
14Chromsome breakage (HP:0040012)3.09588749
15Irregular epiphyses (HP:0010582)3.01808567
16Degeneration of anterior horn cells (HP:0002398)2.99131422
17Abnormality of the anterior horn cell (HP:0006802)2.99131422
18Oral leukoplakia (HP:0002745)2.98954109
19Macrocytic anemia (HP:0001972)2.93230613
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87608582
21Increased nuchal translucency (HP:0010880)2.80258057
22Pallor (HP:0000980)2.77861446
23Entropion (HP:0000621)2.72819955
24Abnormality of the preputium (HP:0100587)2.66535278
25Abnormal trabecular bone morphology (HP:0100671)2.62145472
26Impulsivity (HP:0100710)2.58032954
27Nephroblastoma (Wilms tumor) (HP:0002667)2.54721227
28Abnormality of chromosome stability (HP:0003220)2.50782999
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.50752712
30Embryonal renal neoplasm (HP:0011794)2.50339965
31Selective tooth agenesis (HP:0001592)2.48452771
32Meckel diverticulum (HP:0002245)2.48260474
33Acute encephalopathy (HP:0006846)2.48046775
34Secondary amenorrhea (HP:0000869)2.47225967
35Premature graying of hair (HP:0002216)2.43963235
36Absent radius (HP:0003974)2.35518981
37Cortical dysplasia (HP:0002539)2.32213972
38Abnormality of the ileum (HP:0001549)2.28255348
39Hepatocellular necrosis (HP:0001404)2.27248747
40Increased hepatocellular lipid droplets (HP:0006565)2.26872567
41Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.26833328
42Absent epiphyses (HP:0010577)2.26833328
43Abnormality of methionine metabolism (HP:0010901)2.26093229
44Abnormality of the duodenum (HP:0002246)2.25946288
45Bone marrow hypocellularity (HP:0005528)2.24037136
46Glossoptosis (HP:0000162)2.23720447
4711 pairs of ribs (HP:0000878)2.23528284
48Microretrognathia (HP:0000308)2.23133002
49Colon cancer (HP:0003003)2.21872939
50Horseshoe kidney (HP:0000085)2.21781853
51Abnormality of the umbilical cord (HP:0010881)2.21689754
52Myelodysplasia (HP:0002863)2.21357603
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18046800
54Aplasia involving forearm bones (HP:0009822)2.17790684
55Absent forearm bone (HP:0003953)2.17790684
56Increased CSF lactate (HP:0002490)2.17259979
57Septo-optic dysplasia (HP:0100842)2.17254770
58Mitochondrial inheritance (HP:0001427)2.17201391
59Ureteral duplication (HP:0000073)2.16980092
60Duodenal stenosis (HP:0100867)2.16313613
61Small intestinal stenosis (HP:0012848)2.16313613
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.14511401
63Increased serum lactate (HP:0002151)2.13879924
64Acute necrotizing encephalopathy (HP:0006965)2.13219303
65Abnormality of the septum pellucidum (HP:0007375)2.13199133
66Atresia of the external auditory canal (HP:0000413)2.12270751
67Absent thumb (HP:0009777)2.11765982
68Stenosis of the external auditory canal (HP:0000402)2.11762349
69Abnormality of the labia minora (HP:0012880)2.11049146
70Abnormality of glycolysis (HP:0004366)2.10369055
71Increased serum pyruvate (HP:0003542)2.10369055
72Abnormality of the carotid arteries (HP:0005344)2.10357651
73Neoplasm of the pancreas (HP:0002894)2.09100348
74Trismus (HP:0000211)2.08199613
75Abnormal lung lobation (HP:0002101)2.05924151
76Progressive macrocephaly (HP:0004481)2.04899740
77Short middle phalanx of the 5th finger (HP:0004220)2.04528589
78Congenital, generalized hypertrichosis (HP:0004540)2.04105556
79CNS hypomyelination (HP:0003429)2.00615344
80Cerebral edema (HP:0002181)1.99318555
81Microvesicular hepatic steatosis (HP:0001414)1.98470064
82Absent septum pellucidum (HP:0001331)1.97840117
83Abnormal spermatogenesis (HP:0008669)1.97139508
84Squamous cell carcinoma (HP:0002860)1.95704908
85Triphalangeal thumb (HP:0001199)1.94425972
86Sloping forehead (HP:0000340)1.94248127
87Slender long bone (HP:0003100)1.93480437
88Proximal placement of thumb (HP:0009623)1.93460899
89Multiple enchondromatosis (HP:0005701)1.92605947
90Abnormal number of incisors (HP:0011064)1.92274692
91Hypoplasia of the radius (HP:0002984)1.91323837
92Lipid accumulation in hepatocytes (HP:0006561)1.89874881
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89705640
94Abnormality of alanine metabolism (HP:0010916)1.89705640
95Hyperalaninemia (HP:0003348)1.89705640
96Pelvic girdle muscle weakness (HP:0003749)1.89597460
97Shoulder girdle muscle weakness (HP:0003547)1.87488722
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85709891
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84314782
100Stillbirth (HP:0003826)1.83753123
101Premature ovarian failure (HP:0008209)1.83539551
102Abnormal mitochondria in muscle tissue (HP:0008316)1.82811734
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82341110
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82341110
105Cellular immunodeficiency (HP:0005374)1.81691128
106Hepatic necrosis (HP:0002605)1.81038744
107Respiratory difficulties (HP:0002880)1.80917223
108Ectopic kidney (HP:0000086)1.80499710
109Exertional dyspnea (HP:0002875)1.80441702
110Facial cleft (HP:0002006)1.80388189
111Neoplasm of the colon (HP:0100273)1.79129921
112Sparse eyelashes (HP:0000653)1.78959961
113Reduced antithrombin III activity (HP:0001976)1.78438467
114Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78259187
115Progressive external ophthalmoplegia (HP:0000590)1.77701271
116Abnormality of serum amino acid levels (HP:0003112)1.77685376
117Postnatal microcephaly (HP:0005484)1.77681804
118Missing ribs (HP:0000921)1.77012270
119Microglossia (HP:0000171)1.76718037
120Rhabdomyosarcoma (HP:0002859)1.76034731
121Overlapping toe (HP:0001845)1.75929312
122Type I transferrin isoform profile (HP:0003642)1.75096251
123Progressive muscle weakness (HP:0003323)1.75025771
124Sparse lateral eyebrow (HP:0005338)1.74656004
125Muscle fiber atrophy (HP:0100295)1.74432180
126Deviation of the thumb (HP:0009603)1.74264958
127Duplicated collecting system (HP:0000081)1.74229599
128Choanal atresia (HP:0000453)1.72801090
129Duplication of thumb phalanx (HP:0009942)1.72658349
130Pancytopenia (HP:0001876)1.72273906
131Type 2 muscle fiber atrophy (HP:0003554)1.71683020
132Bilateral microphthalmos (HP:0007633)1.67995237
133Abnormality of cochlea (HP:0000375)1.67718324
134Hyperglycinemia (HP:0002154)1.67179532
135Megaloblastic anemia (HP:0001889)1.67031133
136Renal Fanconi syndrome (HP:0001994)1.66892835
137Abnormality of the pons (HP:0007361)1.65904357
138Medulloblastoma (HP:0002885)1.65494665
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.65235574
140Leukodystrophy (HP:0002415)1.62653110
141Abnormality of the fetal cardiovascular system (HP:0010948)1.60034975
142Abnormal umbilical cord blood vessels (HP:0011403)1.60034975
143Single umbilical artery (HP:0001195)1.60034975
144Hypoplasia of the pons (HP:0012110)1.58581504
145Hyperglycinuria (HP:0003108)1.57145196
146Exercise intolerance (HP:0003546)1.54978544
147Gonadotropin excess (HP:0000837)1.54966540
148Bifid tongue (HP:0010297)1.53334109
149Short tibia (HP:0005736)1.52863162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.63397696
2WEE14.26985729
3EIF2AK14.21593728
4CDC73.52765329
5NME22.79235353
6SRPK12.70536236
7MKNK12.68638778
8BRSK22.67521825
9ACVR1B2.62713627
10STK162.57819369
11PLK42.53278075
12EIF2AK32.51146180
13VRK22.50271987
14MKNK22.31641883
15TSSK62.27959816
16NEK22.25959903
17TAF12.01128340
18TTK1.96728897
19PLK11.93550754
20VRK11.93154206
21PLK31.88425348
22DYRK31.85398761
23TRIM281.72999989
24TNIK1.65993987
25AURKB1.61463647
26NEK11.59393023
27BRSK11.45240448
28ZAK1.42299600
29CDK81.42079529
30CDK71.41141132
31PIM21.40513502
32ATR1.34610870
33RPS6KA41.32484723
34AURKA1.27753483
35TLK11.27307490
36CHEK21.25848741
37PASK1.25393153
38TESK21.20981228
39PBK1.17517854
40RPS6KB21.17377719
41NUAK11.11533601
42CHEK11.08934708
43LIMK11.08474493
44MAP3K101.05588876
45PNCK1.04595075
46TGFBR11.03990945
47LATS21.00817107
48MAP3K80.99832226
49CCNB10.98322726
50NME10.94781997
51BRAF0.92304368
52EIF2AK20.89180513
53STK40.88104452
54BRD40.85438081
55WNK30.83459619
56ATM0.82656546
57PDK20.81175497
58CDK40.78644571
59CSNK2A10.76162492
60BCR0.75155903
61CSNK2A20.74657810
62RPS6KA50.74597378
63ERBB40.74077422
64STK30.73929999
65LATS10.73750455
66EPHA20.69639224
67CDK20.68442246
68STK240.68098996
69STK100.64940126
70MAP3K90.64219598
71STK38L0.64111991
72PIM10.63159205
73FGFR10.61870867
74DYRK20.61825981
75PAK10.61432033
76PAK40.61324076
77CDK10.59281779
78MST40.56353562
79PLK20.56002288
80CDK60.55128527
81PRKCI0.54555592
82AKT30.51112323
83MELK0.50189964
84STK390.49566245
85TESK10.48923422
86CLK10.48617464
87CSNK1G30.48580115
88MAP3K40.48544553
89PDK40.48281384
90PDK30.48281384
91SCYL20.46705902
92DMPK0.46198761
93IRAK30.46050895
94CDK120.44004085
95NEK90.42647739
96BMPR1B0.41597432
97CSNK1E0.40807732
98MAPKAPK50.40498586
99EEF2K0.38238381
100CSNK1G20.34371321
101MAP2K20.31949400
102ERBB30.29818360
103ILK0.29755613
104CDK11A0.29490211
105ABL20.28670955
106CSNK1G10.28161004
107FLT30.27269098
108CAMK1G0.27046158
109MAPK140.26609888
110CDK180.26390615
111WNK40.24749926
112PRKDC0.24378050
113KDR0.24191162
114CDK150.23942319
115CDK140.23586609
116PRKACB0.23371824
117MAP3K110.22840705
118ALK0.22324488
119MAP2K30.22225954
120AKT20.22076383
121TEC0.21736297
122CDK30.20122363
123MARK30.19483911
124PAK20.19228373
125MAPKAPK20.18151431
126LRRK20.18126763
127YES10.17918649
128CDK90.17072583

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15576020
2RNA polymerase_Homo sapiens_hsa030203.93693640
3Proteasome_Homo sapiens_hsa030503.79890560
4Ribosome_Homo sapiens_hsa030103.79314742
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74535063
6Mismatch repair_Homo sapiens_hsa034303.45413589
7Spliceosome_Homo sapiens_hsa030403.24115688
8RNA transport_Homo sapiens_hsa030133.11335272
9Homologous recombination_Homo sapiens_hsa034402.88017224
10Nucleotide excision repair_Homo sapiens_hsa034202.82065489
11Cell cycle_Homo sapiens_hsa041102.79805503
12Base excision repair_Homo sapiens_hsa034102.61507947
13Pyrimidine metabolism_Homo sapiens_hsa002402.58278953
14Basal transcription factors_Homo sapiens_hsa030222.51442208
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15455976
16Fanconi anemia pathway_Homo sapiens_hsa034602.07846449
17Vitamin B6 metabolism_Homo sapiens_hsa007502.06702316
18Protein export_Homo sapiens_hsa030602.04416062
19RNA degradation_Homo sapiens_hsa030181.94412816
20Non-homologous end-joining_Homo sapiens_hsa034501.86397579
21One carbon pool by folate_Homo sapiens_hsa006701.82172418
22mRNA surveillance pathway_Homo sapiens_hsa030151.66467823
23p53 signaling pathway_Homo sapiens_hsa041151.54999323
24Purine metabolism_Homo sapiens_hsa002301.52339943
25Pyruvate metabolism_Homo sapiens_hsa006201.51100362
26Propanoate metabolism_Homo sapiens_hsa006401.33578369
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29839373
28Parkinsons disease_Homo sapiens_hsa050121.28914714
29Huntingtons disease_Homo sapiens_hsa050161.23149612
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22713201
31Oxidative phosphorylation_Homo sapiens_hsa001901.22694149
32Epstein-Barr virus infection_Homo sapiens_hsa051691.20578578
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06007565
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98760240
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95906946
36Oocyte meiosis_Homo sapiens_hsa041140.95123970
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94938108
38Sulfur relay system_Homo sapiens_hsa041220.94528253
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93827964
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92513724
41Folate biosynthesis_Homo sapiens_hsa007900.89228475
42Fatty acid elongation_Homo sapiens_hsa000620.88393308
43Systemic lupus erythematosus_Homo sapiens_hsa053220.87576661
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83763684
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79228366
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78765751
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76304307
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.74752600
49Viral carcinogenesis_Homo sapiens_hsa052030.73989428
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73590965
51Thyroid cancer_Homo sapiens_hsa052160.71809070
52Pentose phosphate pathway_Homo sapiens_hsa000300.71121442
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70679437
54Herpes simplex infection_Homo sapiens_hsa051680.70233208
55Antigen processing and presentation_Homo sapiens_hsa046120.67232255
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65550041
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62200820
58Regulation of autophagy_Homo sapiens_hsa041400.62124008
59Glutathione metabolism_Homo sapiens_hsa004800.60851083
60Alzheimers disease_Homo sapiens_hsa050100.58620809
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58317199
62Wnt signaling pathway_Homo sapiens_hsa043100.54516260
63HTLV-I infection_Homo sapiens_hsa051660.50892116
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43386207
65Arachidonic acid metabolism_Homo sapiens_hsa005900.42749921
66N-Glycan biosynthesis_Homo sapiens_hsa005100.40722995
67MicroRNAs in cancer_Homo sapiens_hsa052060.39236772
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.38409951
69Metabolic pathways_Homo sapiens_hsa011000.38049228
70Small cell lung cancer_Homo sapiens_hsa052220.38047260
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37078687
72Alcoholism_Homo sapiens_hsa050340.36328307
73Linoleic acid metabolism_Homo sapiens_hsa005910.35422815
74Selenocompound metabolism_Homo sapiens_hsa004500.34632555
75Butanoate metabolism_Homo sapiens_hsa006500.33147298
76Legionellosis_Homo sapiens_hsa051340.32787996
77Fatty acid metabolism_Homo sapiens_hsa012120.32305236
78Biosynthesis of amino acids_Homo sapiens_hsa012300.31488705
79Lysine degradation_Homo sapiens_hsa003100.29853755
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29769561
81Sulfur metabolism_Homo sapiens_hsa009200.29091616
82TGF-beta signaling pathway_Homo sapiens_hsa043500.29012913
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.27446324
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27299655
85Bladder cancer_Homo sapiens_hsa052190.26753427
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26168565
87Sphingolipid metabolism_Homo sapiens_hsa006000.24941762
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24662935
89Apoptosis_Homo sapiens_hsa042100.24371673
90Adherens junction_Homo sapiens_hsa045200.23535778
91Hippo signaling pathway_Homo sapiens_hsa043900.23338918
92Hematopoietic cell lineage_Homo sapiens_hsa046400.21731838
93Shigellosis_Homo sapiens_hsa051310.20291634
94Prostate cancer_Homo sapiens_hsa052150.19914899
95Peroxisome_Homo sapiens_hsa041460.19771225
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17578825
97Hepatitis B_Homo sapiens_hsa051610.17275315
98Ether lipid metabolism_Homo sapiens_hsa005650.16321415
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15587998
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15347838
101Carbon metabolism_Homo sapiens_hsa012000.14349867
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14337367
103beta-Alanine metabolism_Homo sapiens_hsa004100.13339592
104Cardiac muscle contraction_Homo sapiens_hsa042600.13288472
105Pathways in cancer_Homo sapiens_hsa052000.13252144
106Tight junction_Homo sapiens_hsa045300.13237304
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12773611
108Melanoma_Homo sapiens_hsa052180.11913597
109Colorectal cancer_Homo sapiens_hsa052100.11756369
110Vitamin digestion and absorption_Homo sapiens_hsa049770.11505474
111Measles_Homo sapiens_hsa051620.11284958
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.08092552
113Hedgehog signaling pathway_Homo sapiens_hsa043400.07582104
114HIF-1 signaling pathway_Homo sapiens_hsa040660.07564027
115Arginine and proline metabolism_Homo sapiens_hsa003300.07047688
116FoxO signaling pathway_Homo sapiens_hsa040680.07026303
117Asthma_Homo sapiens_hsa053100.06592955
118Chronic myeloid leukemia_Homo sapiens_hsa052200.06031331
119Basal cell carcinoma_Homo sapiens_hsa052170.05361374
120Fatty acid degradation_Homo sapiens_hsa000710.04603692
121Arginine biosynthesis_Homo sapiens_hsa002200.03996398
122Steroid biosynthesis_Homo sapiens_hsa001000.03411109
123Galactose metabolism_Homo sapiens_hsa000520.03405315
124Fructose and mannose metabolism_Homo sapiens_hsa000510.02761320
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.02145118

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