METTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.67536286
2maturation of SSU-rRNA (GO:0030490)5.60260386
3DNA deamination (GO:0045006)5.43124618
4chaperone-mediated protein transport (GO:0072321)4.76211454
5ribosomal large subunit biogenesis (GO:0042273)4.74282397
6viral transcription (GO:0019083)4.59883535
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.52629366
8ribosomal small subunit biogenesis (GO:0042274)4.51981129
9telomere maintenance via semi-conservative replication (GO:0032201)4.47836308
10translational termination (GO:0006415)4.46607565
11ribosome assembly (GO:0042255)4.45171194
12cotranslational protein targeting to membrane (GO:0006613)4.41100570
13protein targeting to ER (GO:0045047)4.39570174
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.28674841
15negative regulation of ligase activity (GO:0051352)4.28674841
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.26558485
17pseudouridine synthesis (GO:0001522)4.25893517
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.24676968
19DNA strand elongation involved in DNA replication (GO:0006271)4.24150302
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.16378090
21protein localization to endoplasmic reticulum (GO:0070972)4.16257364
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.09516148
23DNA strand elongation (GO:0022616)4.09407088
24telomere maintenance via recombination (GO:0000722)4.04652778
25regulation of cellular amino acid metabolic process (GO:0006521)4.04245040
26ribonucleoprotein complex biogenesis (GO:0022613)4.01523376
27translational elongation (GO:0006414)3.97403276
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94933881
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.94284169
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87415620
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.87028242
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.84545820
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81233726
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81233726
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81233726
36protein targeting to mitochondrion (GO:0006626)3.81077895
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.81049043
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.81049043
39DNA replication initiation (GO:0006270)3.78996233
40nucleobase biosynthetic process (GO:0046112)3.78824095
41DNA replication checkpoint (GO:0000076)3.74993049
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.72761342
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.72761342
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.71318246
45termination of RNA polymerase III transcription (GO:0006386)3.71318246
46rRNA processing (GO:0006364)3.70212115
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.68915698
48translational initiation (GO:0006413)3.67379108
49spliceosomal snRNP assembly (GO:0000387)3.66861909
50telomere maintenance via telomere lengthening (GO:0010833)3.64558843
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.63012156
52rRNA modification (GO:0000154)3.61662293
53mitotic metaphase plate congression (GO:0007080)3.60895053
54translation (GO:0006412)3.59819997
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59643823
56ribosome biogenesis (GO:0042254)3.59327319
57mitotic recombination (GO:0006312)3.56923900
58rRNA metabolic process (GO:0016072)3.56680941
59positive regulation of ligase activity (GO:0051351)3.53063715
60spliceosomal complex assembly (GO:0000245)3.52045512
61viral life cycle (GO:0019058)3.51952135
62viral mRNA export from host cell nucleus (GO:0046784)3.48738200
63proteasome assembly (GO:0043248)3.42851195
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.41981151
65establishment of viral latency (GO:0019043)3.40480472
66positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.40384435
67establishment of protein localization to mitochondrion (GO:0072655)3.39617165
68transcription-coupled nucleotide-excision repair (GO:0006283)3.39323715
69regulation of ubiquitin-protein transferase activity (GO:0051438)3.38995931
70cellular protein complex disassembly (GO:0043624)3.38924377
71cellular component biogenesis (GO:0044085)3.36920678
72protein localization to mitochondrion (GO:0070585)3.34620174
73purine nucleobase biosynthetic process (GO:0009113)3.33870761
74IMP biosynthetic process (GO:0006188)3.33265200
75* tRNA methylation (GO:0030488)3.32364110
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31560625
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.30618844
78formation of translation preinitiation complex (GO:0001731)3.29363229
79ATP synthesis coupled proton transport (GO:0015986)3.27862403
80energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27862403
81regulation of ligase activity (GO:0051340)3.26912458
82regulation of mitochondrial translation (GO:0070129)3.26738749
83mitochondrial RNA metabolic process (GO:0000959)3.26391873
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23049246
85nucleobase-containing small molecule interconversion (GO:0015949)3.19905627
86mitochondrial respiratory chain complex assembly (GO:0033108)3.19280937
87intra-S DNA damage checkpoint (GO:0031573)3.17974079
88cell cycle G1/S phase transition (GO:0044843)3.17532252
89G1/S transition of mitotic cell cycle (GO:0000082)3.17532252
90protein complex biogenesis (GO:0070271)3.15397544
91termination of RNA polymerase I transcription (GO:0006363)3.15185960
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.14788632
93NADH dehydrogenase complex assembly (GO:0010257)3.14788632
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14788632
95negative regulation of protein ubiquitination (GO:0031397)3.13828085
96rRNA methylation (GO:0031167)3.13673079
97DNA catabolic process, exonucleolytic (GO:0000738)3.12773544
98transcription from RNA polymerase I promoter (GO:0006360)3.11802507
99cytochrome complex assembly (GO:0017004)3.11271052
100antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.08988350
101* ncRNA processing (GO:0034470)3.07590347
102transcription from mitochondrial promoter (GO:0006390)3.07455273
103protein deneddylation (GO:0000338)3.06496223
104transcription elongation from RNA polymerase I promoter (GO:0006362)3.06345371
105pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04803426
106cullin deneddylation (GO:0010388)3.04310687
107chromatin remodeling at centromere (GO:0031055)3.03910136
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03109323
109* tRNA modification (GO:0006400)3.02552236
110protein maturation by protein folding (GO:0022417)3.02289258
111DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.02216361
112protein complex disassembly (GO:0043241)3.01265626
113regulation of cellular amine metabolic process (GO:0033238)3.01125366
114positive regulation of cell cycle arrest (GO:0071158)3.00616699
115CENP-A containing nucleosome assembly (GO:0034080)3.00297586
116metaphase plate congression (GO:0051310)3.00033014
117nuclear-transcribed mRNA catabolic process (GO:0000956)2.99156015
118maturation of 5.8S rRNA (GO:0000460)2.98846005
119negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.98471192
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.95776519
121folic acid-containing compound biosynthetic process (GO:0009396)2.94675950
122GTP biosynthetic process (GO:0006183)2.93482891
123UTP biosynthetic process (GO:0006228)2.93266108
124tRNA aminoacylation for protein translation (GO:0006418)2.92738022
125peptidyl-histidine modification (GO:0018202)2.92185351
126protein K6-linked ubiquitination (GO:0085020)2.92004112
127respiratory electron transport chain (GO:0022904)2.91933223
128macromolecular complex disassembly (GO:0032984)2.90587160
129RNA-dependent DNA replication (GO:0006278)2.90564957
130kinetochore assembly (GO:0051382)2.89937173
131* ncRNA metabolic process (GO:0034660)2.89775966
132establishment of integrated proviral latency (GO:0075713)2.89730834
133tRNA aminoacylation (GO:0043039)2.88543869
134amino acid activation (GO:0043038)2.88543869
135telomere maintenance (GO:0000723)2.88493804
136telomere organization (GO:0032200)2.88207468
1377-methylguanosine mRNA capping (GO:0006370)2.88142371
138mRNA catabolic process (GO:0006402)2.88032298
139* tRNA processing (GO:0008033)2.85614397
140guanosine-containing compound biosynthetic process (GO:1901070)2.85112522
1417-methylguanosine RNA capping (GO:0009452)2.85046655
142RNA capping (GO:0036260)2.85046655
143maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83851748
144DNA-templated transcription, termination (GO:0006353)2.82037846
145RNA catabolic process (GO:0006401)2.78687964
146* RNA methylation (GO:0001510)2.78596735
147respiratory chain complex IV assembly (GO:0008535)2.78231574
148kinetochore organization (GO:0051383)2.77634756
149pteridine-containing compound biosynthetic process (GO:0042559)2.77104775
150signal peptide processing (GO:0006465)2.75444904
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74295844
152IMP metabolic process (GO:0046040)2.74185994
153* RNA modification (GO:0009451)2.73172031
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71825824
155DNA ligation (GO:0006266)2.69504165
156transcription initiation from RNA polymerase I promoter (GO:0006361)2.68568786
157replication fork processing (GO:0031297)2.66040613
158RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.65416178
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63742196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38473496
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.42539118
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.07130070
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71772100
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.67802074
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.55143880
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49278471
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.31115936
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21430696
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15450064
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06797511
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92485834
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89085796
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79805837
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77761090
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72862582
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59204985
18* VDR_23849224_ChIP-Seq_CD4+_Human2.56420536
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48516934
20* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47235129
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45094884
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38823993
23FOXP3_21729870_ChIP-Seq_TREG_Human2.37659325
24DCP1A_22483619_ChIP-Seq_HELA_Human2.22361515
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21413259
26XRN2_22483619_ChIP-Seq_HELA_Human2.20721347
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12736319
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11925303
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.09487404
30* NOTCH1_21737748_ChIP-Seq_TLL_Human2.08951365
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08330043
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02360894
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02113054
34TTF2_22483619_ChIP-Seq_HELA_Human2.01092346
35GABP_19822575_ChIP-Seq_HepG2_Human2.00669201
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92337679
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.86800772
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85981653
39ELK1_19687146_ChIP-ChIP_HELA_Human1.83916501
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82325871
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.80423704
42CIITA_25753668_ChIP-Seq_RAJI_Human1.74459329
43* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72531864
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72466987
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71565764
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71293867
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71171034
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68653996
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68523264
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67887251
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65075257
52* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64596747
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61990544
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56421765
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38089156
56ZNF263_19887448_ChIP-Seq_K562_Human1.38009802
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.36801103
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33393200
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32897959
60* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32268133
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31453405
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31280304
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31060598
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.24125516
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21610513
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19720648
67KDM5A_27292631_Chip-Seq_BREAST_Human1.19331925
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18794569
69* MYC_18940864_ChIP-ChIP_HL60_Human1.18700979
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17767127
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17409836
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17077695
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16274448
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16137976
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16137976
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16137976
77TFEB_21752829_ChIP-Seq_HELA_Human1.14731141
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.14509085
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14264406
80IRF1_19129219_ChIP-ChIP_H3396_Human1.13563927
81SPI1_23547873_ChIP-Seq_NB4_Human1.12901608
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12465166
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05788620
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03930483
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02151422
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01945936
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01468039
88* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97558535
89AR_21909140_ChIP-Seq_LNCAP_Human0.96576611
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95596136
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92992282
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89199051
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88392082
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87207135
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.86315482
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86083858
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85671742
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85067101
99* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84290698
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83072554
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82736606
102ELF5_23300383_ChIP-Seq_T47D_Human0.82675108
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82668220
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82156317
105EGR1_19374776_ChIP-ChIP_THP-1_Human0.81859604
106MYC_22102868_ChIP-Seq_BL_Human0.81276141
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81208918
108SCL_19346495_ChIP-Seq_HPC-7_Human0.80333017
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79978403
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78709850
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78062393
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76358877
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76212922
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75315949
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73223415
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70735129
117STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70571963
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.69306021
119VDR_21846776_ChIP-Seq_THP-1_Human0.66590791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.12513127
2MP0008057_abnormal_DNA_replication3.75336067
3MP0008058_abnormal_DNA_repair3.36068078
4MP0010094_abnormal_chromosome_stability3.21832423
5MP0003941_abnormal_skin_development3.20379853
6MP0004957_abnormal_blastocyst_morpholog3.17812738
7MP0003111_abnormal_nucleus_morphology3.08542254
8MP0009379_abnormal_foot_pigmentation2.84988695
9MP0003077_abnormal_cell_cycle2.70096022
10MP0008007_abnormal_cellular_replicative2.57758534
11MP0001188_hyperpigmentation2.52347739
12MP0001853_heart_inflammation2.51296743
13MP0006036_abnormal_mitochondrial_physio2.45900852
14MP0000566_synostosis2.42475726
15MP0006292_abnormal_olfactory_placode2.41031855
16MP0002396_abnormal_hematopoietic_system2.39950925
17MP0005174_abnormal_tail_pigmentation2.36285082
18MP0008932_abnormal_embryonic_tissue2.32376152
19MP0001986_abnormal_taste_sensitivity2.28300018
20MP0005379_endocrine/exocrine_gland_phen2.07034175
21MP0003786_premature_aging2.06369514
22MP0002254_reproductive_system_inflammat2.03920003
23MP0005058_abnormal_lysosome_morphology2.01718080
24MP0000015_abnormal_ear_pigmentation1.88445811
25MP0005075_abnormal_melanosome_morpholog1.85285836
26MP0006035_abnormal_mitochondrial_morpho1.82785358
27MP0002132_abnormal_respiratory_system1.80510531
28MP0005451_abnormal_body_composition1.79713343
29MP0000490_abnormal_crypts_of1.78626107
30MP0003136_yellow_coat_color1.78366417
31MP0002095_abnormal_skin_pigmentation1.70180201
32MP0009840_abnormal_foam_cell1.68191491
33MP0000358_abnormal_cell_content/1.62895205
34MP0003763_abnormal_thymus_physiology1.60463769
35MP0000678_abnormal_parathyroid_gland1.58680667
36MP0002938_white_spotting1.57591363
37MP0002163_abnormal_gland_morphology1.54992718
38MP0009697_abnormal_copulation1.49939264
39MP0003123_paternal_imprinting1.45529501
40MP0010307_abnormal_tumor_latency1.44537572
41MP0003718_maternal_effect1.39279165
42MP0000343_altered_response_to1.36944229
43MP0009333_abnormal_splenocyte_physiolog1.30751201
44MP0003186_abnormal_redox_activity1.24747299
45MP0003448_altered_tumor_morphology1.19047576
46MP0008877_abnormal_DNA_methylation1.16777301
47MP0000613_abnormal_salivary_gland1.16539910
48MP0003191_abnormal_cellular_cholesterol1.15960480
49MP0000313_abnormal_cell_death1.14866606
50MP0005220_abnormal_exocrine_pancreas1.14144728
51MP0000049_abnormal_middle_ear1.12274270
52MP0005165_increased_susceptibility_to1.11524378
53MP0001881_abnormal_mammary_gland1.10646126
54MP0002638_abnormal_pupillary_reflex1.08547535
55MP0003806_abnormal_nucleotide_metabolis1.08362061
56MP0003075_altered_response_to1.07071380
57MP0000350_abnormal_cell_proliferation1.06862671
58MP0006082_CNS_inflammation1.06488270
59MP0004381_abnormal_hair_follicle1.06257810
60MP0005671_abnormal_response_to1.06064757
61MP0002019_abnormal_tumor_incidence1.03697463
62MP0002277_abnormal_respiratory_mucosa1.03681674
63MP0005171_absent_coat_pigmentation1.03407793
64MP0004808_abnormal_hematopoietic_stem1.03195006
65MP0003121_genomic_imprinting1.01765096
66MP0001186_pigmentation_phenotype1.00323044
67MP0002398_abnormal_bone_marrow0.98373068
68MP0001919_abnormal_reproductive_system0.97604790
69MP0000681_abnormal_thyroid_gland0.97576573
70MP0005501_abnormal_skin_physiology0.97477772
71MP0008875_abnormal_xenobiotic_pharmacok0.96893094
72MP0002877_abnormal_melanocyte_morpholog0.96581834
73MP0001873_stomach_inflammation0.95456852
74MP0000703_abnormal_thymus_morphology0.95187028
75MP0005395_other_phenotype0.93762722
76MP0008995_early_reproductive_senescence0.93254708
77MP0001293_anophthalmia0.92647814
78MP0001835_abnormal_antigen_presentation0.92578535
79MP0005410_abnormal_fertilization0.92294620
80MP0005409_darkened_coat_color0.92029586
81MP0002075_abnormal_coat/hair_pigmentati0.91760639
82MP0005380_embryogenesis_phenotype0.91520336
83MP0001672_abnormal_embryogenesis/_devel0.91520336
84MP0000372_irregular_coat_pigmentation0.91254393
85MP0001727_abnormal_embryo_implantation0.90957509
86MP0000858_altered_metastatic_potential0.90657580
87MP0005330_cardiomyopathy0.90484899
88MP0005389_reproductive_system_phenotype0.89435721
89MP0010030_abnormal_orbit_morphology0.88921188
90MP0000465_gastrointestinal_hemorrhage0.87920669
91MP0002177_abnormal_outer_ear0.87594682
92MP0005319_abnormal_enzyme/_coenzyme0.86875802
93MP0001542_abnormal_bone_strength0.86719502
94MP0002210_abnormal_sex_determination0.85717180
95MP0003315_abnormal_perineum_morphology0.85142758
96MP0005408_hypopigmentation0.84263598
97MP0002429_abnormal_blood_cell0.83210423
98MP0002139_abnormal_hepatobiliary_system0.83204070
99MP0001119_abnormal_female_reproductive0.82896565
100MP0002148_abnormal_hypersensitivity_rea0.82838223
101MP0008873_increased_physiological_sensi0.82498072
102MP0002722_abnormal_immune_system0.80508617
103MP0002693_abnormal_pancreas_physiology0.79554080
104MP0000689_abnormal_spleen_morphology0.79316477
105MP0000750_abnormal_muscle_regeneration0.79039746
106MP0001730_embryonic_growth_arrest0.79036517
107MP0003724_increased_susceptibility_to0.76831735
108MP0008469_abnormal_protein_level0.76717204
109MP0003567_abnormal_fetal_cardiomyocyte0.76397853
110MP0009764_decreased_sensitivity_to0.75749097
111MP0005384_cellular_phenotype0.75579835
112MP0009785_altered_susceptibility_to0.75521479
113MP0006054_spinal_hemorrhage0.75049716
114MP0006072_abnormal_retinal_apoptosis0.74942040
115MP0001346_abnormal_lacrimal_gland0.74442628
116MP0002080_prenatal_lethality0.74192405
117MP0000716_abnormal_immune_system0.74173391
118MP0000627_abnormal_mammary_gland0.74171982
119MP0009278_abnormal_bone_marrow0.73946351
120MP0003984_embryonic_growth_retardation0.73935731
121MP0008789_abnormal_olfactory_epithelium0.73730593
122MP0003787_abnormal_imprinting0.73274062
123MP0005266_abnormal_metabolism0.73166686
124MP0001764_abnormal_homeostasis0.73048140
125MP0000371_diluted_coat_color0.72792405
126MP0001145_abnormal_male_reproductive0.72348477
127MP0003950_abnormal_plasma_membrane0.71928070
128MP0001929_abnormal_gametogenesis0.71564926
129MP0002088_abnormal_embryonic_growth/wei0.70010631
130MP0001661_extended_life_span0.69956532
131MP0001697_abnormal_embryo_size0.69788449
132MP0003453_abnormal_keratinocyte_physiol0.69740487
133MP0002751_abnormal_autonomic_nervous0.68775231
134MP0001800_abnormal_humoral_immune0.67753897
135MP0003943_abnormal_hepatobiliary_system0.67123011
136MP0002420_abnormal_adaptive_immunity0.66773801
137MP0005646_abnormal_pituitary_gland0.66746556
138MP0010386_abnormal_urinary_bladder0.65697529
139MP0003011_delayed_dark_adaptation0.65243390
140MP0005310_abnormal_salivary_gland0.65214206
141MP0001545_abnormal_hematopoietic_system0.65070755
142MP0005397_hematopoietic_system_phenotyp0.65070755
143MP0002090_abnormal_vision0.64865395
144MP0000653_abnormal_sex_gland0.64702131
145MP0004147_increased_porphyrin_level0.64684450
146MP0000516_abnormal_urinary_system0.64625611
147MP0005332_abnormal_amino_acid0.63626995
148MP0002160_abnormal_reproductive_system0.63030066
149MP0003656_abnormal_erythrocyte_physiolo0.62355619
150MP0002085_abnormal_embryonic_tissue0.61857484
151MP0010352_gastrointestinal_tract_polyps0.61395159
152MP0002796_impaired_skin_barrier0.59644805
153MP0001845_abnormal_inflammatory_respons0.59164407
154MP0009765_abnormal_xenobiotic_induced0.58723115
155MP0002405_respiratory_system_inflammati0.58422206
156MP0004233_abnormal_muscle_weight0.57468809

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.23444453
2Reticulocytopenia (HP:0001896)4.71920072
3Abnormal mitochondria in muscle tissue (HP:0008316)4.38902284
4Acute encephalopathy (HP:0006846)4.28471337
5Abnormal number of erythroid precursors (HP:0012131)3.99179557
6Abnormality of cells of the erythroid lineage (HP:0012130)3.94285833
7Progressive macrocephaly (HP:0004481)3.82203317
8Type I transferrin isoform profile (HP:0003642)3.59015659
9Increased serum pyruvate (HP:0003542)3.54447843
10Cerebral edema (HP:0002181)3.41042100
11Abnormality of glycolysis (HP:0004366)3.35083449
12Lactic acidosis (HP:0003128)3.34532599
13Birth length less than 3rd percentile (HP:0003561)3.34084507
14Pallor (HP:0000980)3.33257516
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28293308
16Multiple enchondromatosis (HP:0005701)3.22830914
17Macrocytic anemia (HP:0001972)3.19878826
18Chromsome breakage (HP:0040012)3.17877681
19Respiratory failure (HP:0002878)3.11951097
20Exercise intolerance (HP:0003546)2.99883720
21Rough bone trabeculation (HP:0100670)2.97625838
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97076386
23Premature graying of hair (HP:0002216)2.92963175
24Microvesicular hepatic steatosis (HP:0001414)2.91304868
25Increased intramyocellular lipid droplets (HP:0012240)2.89831921
26Methylmalonic aciduria (HP:0012120)2.82710009
27Progressive muscle weakness (HP:0003323)2.80491608
28Respiratory difficulties (HP:0002880)2.77661003
29Degeneration of anterior horn cells (HP:0002398)2.74850774
30Abnormality of the anterior horn cell (HP:0006802)2.74850774
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73437947
32Abnormal protein N-linked glycosylation (HP:0012347)2.73437947
33Abnormal protein glycosylation (HP:0012346)2.73437947
34Abnormal glycosylation (HP:0012345)2.73437947
3511 pairs of ribs (HP:0000878)2.69467100
36Bone marrow hypocellularity (HP:0005528)2.69257523
37Pancytopenia (HP:0001876)2.67668089
38Duplicated collecting system (HP:0000081)2.66188129
39Aplasia/hypoplasia of the uterus (HP:0008684)2.63751993
40Abnormality of the renal collecting system (HP:0004742)2.61824136
41Breast hypoplasia (HP:0003187)2.56299387
42Testicular atrophy (HP:0000029)2.54508668
43Abnormality of the umbilical cord (HP:0010881)2.51928290
44Increased muscle lipid content (HP:0009058)2.50547074
45Abnormality of the preputium (HP:0100587)2.47542623
46Abnormality of chromosome stability (HP:0003220)2.45440137
47Oral leukoplakia (HP:0002745)2.43274575
483-Methylglutaconic aciduria (HP:0003535)2.42177060
49Abnormal trabecular bone morphology (HP:0100671)2.41055634
50CNS demyelination (HP:0007305)2.39673074
51Thrombocytosis (HP:0001894)2.37803213
52Meckel diverticulum (HP:0002245)2.37297436
53Reduced antithrombin III activity (HP:0001976)2.35638127
54Abnormality of the ileum (HP:0001549)2.34050932
55Patent foramen ovale (HP:0001655)2.32518469
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28243020
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28243020
58Microretrognathia (HP:0000308)2.26815073
59Trismus (HP:0000211)2.26077230
60Myelodysplasia (HP:0002863)2.24860390
61Asplenia (HP:0001746)2.24009936
62Ragged-red muscle fibers (HP:0003200)2.23586615
63Amniotic constriction ring (HP:0009775)2.23293323
64Abnormality of placental membranes (HP:0011409)2.23293323
65Supernumerary spleens (HP:0009799)2.23292606
66Generalized aminoaciduria (HP:0002909)2.22228559
67Absent thumb (HP:0009777)2.21745706
68Lethargy (HP:0001254)2.20882870
69Abnormalities of placenta or umbilical cord (HP:0001194)2.20743300
70Abnormality of liposaccharide metabolism (HP:0010968)2.19832533
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.19832533
72Abnormality of glycolipid metabolism (HP:0010969)2.19832533
73Increased hepatocellular lipid droplets (HP:0006565)2.18375046
74IgM deficiency (HP:0002850)2.16981919
75Patellar aplasia (HP:0006443)2.15826313
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13570125
77Premature ovarian failure (HP:0008209)2.13511957
78Leukodystrophy (HP:0002415)2.13478342
79Aplasia/Hypoplasia of the patella (HP:0006498)2.12929946
80Dry hair (HP:0011359)2.12161153
81Acute lymphatic leukemia (HP:0006721)2.11424625
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11022792
83Dicarboxylic aciduria (HP:0003215)2.11022792
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.10101913
85Abnormality of methionine metabolism (HP:0010901)2.09840850
86Hypoplasia of the uterus (HP:0000013)2.08482550
87Methylmalonic acidemia (HP:0002912)2.06680761
88Mitochondrial inheritance (HP:0001427)2.05731866
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.05278002
90Cerebral hypomyelination (HP:0006808)2.04653888
91Vacuolated lymphocytes (HP:0001922)2.04124396
92Emotional lability (HP:0000712)2.04051079
93Opisthotonus (HP:0002179)2.01270740
94Hyperalaninemia (HP:0003348)2.01020958
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01020958
96Abnormality of alanine metabolism (HP:0010916)2.01020958
97Increased serum lactate (HP:0002151)2.00897245
98Nausea (HP:0002018)1.99787865
99Muscle fiber atrophy (HP:0100295)1.98388349
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98292033
101Sparse eyelashes (HP:0000653)1.96508251
102Abnormality of DNA repair (HP:0003254)1.94260707
103Optic disc pallor (HP:0000543)1.92846440
104Type 2 muscle fiber atrophy (HP:0003554)1.92518391
105Increased CSF lactate (HP:0002490)1.90967342
106Osteomalacia (HP:0002749)1.90163807
107Triphalangeal thumb (HP:0001199)1.87012789
108Squamous cell carcinoma (HP:0002860)1.86458782
109Lymphoma (HP:0002665)1.86149597
110Carpal bone hypoplasia (HP:0001498)1.85942351
111Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85156619
112Renal Fanconi syndrome (HP:0001994)1.84968237
113Petechiae (HP:0000967)1.84572867
114Abnormal number of incisors (HP:0011064)1.83103388
115Acute necrotizing encephalopathy (HP:0006965)1.81062742
116Abnormality of the fetal cardiovascular system (HP:0010948)1.78783861
117Abnormal umbilical cord blood vessels (HP:0011403)1.78783861
118Single umbilical artery (HP:0001195)1.78783861
119Intestinal atresia (HP:0011100)1.78086894
120Hepatocellular necrosis (HP:0001404)1.78015875
121Pancreatic cysts (HP:0001737)1.77350580
122Lipid accumulation in hepatocytes (HP:0006561)1.77154662
123Death in infancy (HP:0001522)1.76931137
124Hepatosplenomegaly (HP:0001433)1.76576870
125Horseshoe kidney (HP:0000085)1.74325577
126Abnormality of the pons (HP:0007361)1.72535313
127Hypoplasia of the pons (HP:0012110)1.72369423
128Cleft eyelid (HP:0000625)1.69799807
129Exertional dyspnea (HP:0002875)1.69697032
130Hypoplasia of the radius (HP:0002984)1.69002287
131Secondary amenorrhea (HP:0000869)1.67728663
132Abnormality of T cell physiology (HP:0011840)1.67403184
133Selective tooth agenesis (HP:0001592)1.66823992
134Facial cleft (HP:0002006)1.65804158
135Patchy hypopigmentation of hair (HP:0011365)1.64341865
136Irregular epiphyses (HP:0010582)1.64087122
137Hepatic necrosis (HP:0002605)1.63855585
138White forelock (HP:0002211)1.63166271
139Optic nerve coloboma (HP:0000588)1.63122185
140Sloping forehead (HP:0000340)1.62949647
141Megaloblastic anemia (HP:0001889)1.60754007
142Poor head control (HP:0002421)1.59767169
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59696208
144Clubbing of toes (HP:0100760)1.59632566
145Depressed nasal ridge (HP:0000457)1.57016967
146IgG deficiency (HP:0004315)1.56389545
147Pancreatic fibrosis (HP:0100732)1.55841412
148Severe visual impairment (HP:0001141)1.54972132
149True hermaphroditism (HP:0010459)1.54886486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.51321106
2STK164.31424772
3TLK14.02262714
4NME23.25092888
5MKNK23.10107210
6SRPK13.06472506
7EIF2AK12.87707610
8BUB12.68286099
9WEE12.66723953
10MKNK12.53612360
11IRAK42.52946515
12VRK12.43474556
13EIF2AK32.29440398
14IRAK32.24804236
15NEK12.10089581
16ZAK1.96547848
17PDK21.85206316
18PASK1.80994866
19CDC71.73853112
20TSSK61.64279486
21CDK71.49771030
22EPHA21.41862713
23PLK41.40822021
24PAK41.39793874
25TEC1.37821026
26ACVR1B1.36660798
27PIM21.36610780
28ATR1.34822440
29MST1R1.30096629
30TXK1.28864309
31CDK81.26227857
32ABL21.22074105
33BLK1.21253851
34BRSK21.21168456
35NME11.19183766
36TESK11.16822495
37ADRBK21.16701462
38MAP3K111.16449990
39TRIM281.13725865
40TTK1.12058910
41TAF11.10776853
42EIF2AK21.09615837
43MAP4K11.06708048
44AKT31.06605335
45PLK11.06576000
46BCKDK1.05560175
47AURKB1.03519235
48MAPK151.03198049
49FLT31.02335009
50BTK1.01796043
51RPS6KA41.01759077
52MAP3K120.98840267
53RPS6KB20.98046976
54NUAK10.96012101
55CASK0.94114069
56SMG10.94065829
57LIMK10.93859374
58SCYL20.93101595
59PIM10.92492964
60MOS0.91098560
61MAP4K20.90353389
62CHEK20.89769696
63PLK30.89154208
64STK100.89065667
65DAPK10.85728501
66YES10.85039267
67KIT0.84727087
68DYRK30.84503885
69STK38L0.80899335
70CSNK2A10.80663649
71IKBKB0.78978219
72CLK10.77857232
73BRAF0.77743997
74TGFBR10.77193777
75AURKA0.76604045
76CHEK10.74870510
77CSNK2A20.74018421
78ZAP700.71566059
79JAK30.70099182
80ATM0.70081642
81PIK3CG0.69491397
82TAOK20.69356822
83RPS6KA50.68429446
84TESK20.66203697
85TNIK0.62749161
86CCNB10.61585599
87CDK40.60917847
88MAPKAPK30.59957838
89MAP3K140.59028160
90LYN0.58473200
91STK40.58066449
92PAK10.57610057
93BRD40.57083953
94PRKCI0.54007737
95KDR0.53581490
96TIE10.53465376
97ERBB40.53400231
98ALK0.52416612
99CDK90.52250849
100MST40.50666417
101GRK10.50502505
102NLK0.47103855
103CDK20.46526065
104NEK20.45894108
105STK240.44528933
106TBK10.44321869
107PBK0.44032859
108SYK0.43992623
109ERN10.43247901
110SIK30.42442746
111BMPR1B0.40210403
112IRAK10.39925102
113NEK60.39611603
114INSRR0.39358871
115ILK0.39105871
116BRSK10.38833755
117MUSK0.38765681
118NEK90.38058276
119GRK70.37709346
120MAP3K80.37116001
121MAPKAPK50.35699087
122CSNK1G30.35658375
123DAPK30.35639111
124HIPK20.35499065
125MAP2K30.35361457
126IKBKE0.35173560
127CDK30.34920399
128MATK0.34504547
129ARAF0.33340215
130BMPR20.32516066
131MAP3K30.32325821
132DYRK20.31903978
133DDR20.29638128
134PLK20.29002350
135AKT20.28724537
136MELK0.28192578
137MAPKAPK20.27010569
138CSNK1G10.26560306
139MYLK0.24180167
140MAP3K50.23472205
141CDK10.22744626
142CAMK2G0.22093764

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.35487847
2DNA replication_Homo sapiens_hsa030304.23451767
3Mismatch repair_Homo sapiens_hsa034303.65082234
4RNA polymerase_Homo sapiens_hsa030203.53597623
5Protein export_Homo sapiens_hsa030603.20951607
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13053946
7Proteasome_Homo sapiens_hsa030502.95198068
8Homologous recombination_Homo sapiens_hsa034402.94191995
9Spliceosome_Homo sapiens_hsa030402.91865369
10Base excision repair_Homo sapiens_hsa034102.84683042
11Pyrimidine metabolism_Homo sapiens_hsa002402.68527279
12Nucleotide excision repair_Homo sapiens_hsa034202.57025614
13One carbon pool by folate_Homo sapiens_hsa006702.53368042
14Fanconi anemia pathway_Homo sapiens_hsa034602.25372646
15RNA transport_Homo sapiens_hsa030132.18597936
16Non-homologous end-joining_Homo sapiens_hsa034502.12318864
17Basal transcription factors_Homo sapiens_hsa030222.01024204
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97142689
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95056941
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90493629
21RNA degradation_Homo sapiens_hsa030181.72392545
22Cell cycle_Homo sapiens_hsa041101.69581517
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52623154
24Purine metabolism_Homo sapiens_hsa002301.50200632
25Fatty acid elongation_Homo sapiens_hsa000621.49900550
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47707502
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.46116613
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45258866
29Vitamin B6 metabolism_Homo sapiens_hsa007501.38602486
30Folate biosynthesis_Homo sapiens_hsa007901.38066391
31Sulfur metabolism_Homo sapiens_hsa009201.37081835
32Biosynthesis of amino acids_Homo sapiens_hsa012301.25598969
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22694974
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18230185
35Carbon metabolism_Homo sapiens_hsa012001.16736773
36mRNA surveillance pathway_Homo sapiens_hsa030151.16281200
37p53 signaling pathway_Homo sapiens_hsa041151.05697853
38Selenocompound metabolism_Homo sapiens_hsa004501.03991110
39Oxidative phosphorylation_Homo sapiens_hsa001901.01785953
40Pyruvate metabolism_Homo sapiens_hsa006201.00363757
41Parkinsons disease_Homo sapiens_hsa050120.96976126
42Herpes simplex infection_Homo sapiens_hsa051680.94731104
43Other glycan degradation_Homo sapiens_hsa005110.94132273
44N-Glycan biosynthesis_Homo sapiens_hsa005100.94016455
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92226152
46Arachidonic acid metabolism_Homo sapiens_hsa005900.89601432
47Sulfur relay system_Homo sapiens_hsa041220.88947165
48Steroid biosynthesis_Homo sapiens_hsa001000.88598763
49Huntingtons disease_Homo sapiens_hsa050160.88488319
50Epstein-Barr virus infection_Homo sapiens_hsa051690.83543050
51Primary immunodeficiency_Homo sapiens_hsa053400.83187935
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.80912541
53Propanoate metabolism_Homo sapiens_hsa006400.79724321
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78160388
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71739587
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.71657789
57Sphingolipid metabolism_Homo sapiens_hsa006000.67348325
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.65370539
59Systemic lupus erythematosus_Homo sapiens_hsa053220.62639840
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61705581
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60711107
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.57481281
63Lysosome_Homo sapiens_hsa041420.56713664
64Measles_Homo sapiens_hsa051620.56206713
65Antigen processing and presentation_Homo sapiens_hsa046120.55965688
66Hematopoietic cell lineage_Homo sapiens_hsa046400.55565807
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54914249
68Galactose metabolism_Homo sapiens_hsa000520.53349318
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52777311
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51876528
71Glutathione metabolism_Homo sapiens_hsa004800.51730504
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51664299
73Legionellosis_Homo sapiens_hsa051340.51474761
74Arginine and proline metabolism_Homo sapiens_hsa003300.51219414
75Peroxisome_Homo sapiens_hsa041460.50820319
76Bladder cancer_Homo sapiens_hsa052190.50557726
77Metabolic pathways_Homo sapiens_hsa011000.50378216
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48528510
79Linoleic acid metabolism_Homo sapiens_hsa005910.48151389
80Fatty acid metabolism_Homo sapiens_hsa012120.47788728
81Autoimmune thyroid disease_Homo sapiens_hsa053200.46933575
82Rheumatoid arthritis_Homo sapiens_hsa053230.45192903
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45153122
84Allograft rejection_Homo sapiens_hsa053300.42701240
85HTLV-I infection_Homo sapiens_hsa051660.42267513
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42182133
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41884394
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.40836639
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40164458
90Alzheimers disease_Homo sapiens_hsa050100.40065834
91Asthma_Homo sapiens_hsa053100.39666942
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36668482
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36450319
94Collecting duct acid secretion_Homo sapiens_hsa049660.35821184
95Viral carcinogenesis_Homo sapiens_hsa052030.34786300
96Thyroid cancer_Homo sapiens_hsa052160.34591996
97Vibrio cholerae infection_Homo sapiens_hsa051100.33579163
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32128547
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29746233
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29471201
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27350747
102Notch signaling pathway_Homo sapiens_hsa043300.26336649
103Vitamin digestion and absorption_Homo sapiens_hsa049770.25869555
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24927126
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24411356
106Pentose phosphate pathway_Homo sapiens_hsa000300.24325335
107Tryptophan metabolism_Homo sapiens_hsa003800.24109896
108Apoptosis_Homo sapiens_hsa042100.24012051
109Type I diabetes mellitus_Homo sapiens_hsa049400.23978773
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.23973822
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23040952
112Oocyte meiosis_Homo sapiens_hsa041140.22513452
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22299968
114Regulation of autophagy_Homo sapiens_hsa041400.22276167
115Influenza A_Homo sapiens_hsa051640.21211315
116Cardiac muscle contraction_Homo sapiens_hsa042600.21167369
117Fructose and mannose metabolism_Homo sapiens_hsa000510.20763755
118Shigellosis_Homo sapiens_hsa051310.19767651
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18088272
120Mineral absorption_Homo sapiens_hsa049780.17799639
121Graft-versus-host disease_Homo sapiens_hsa053320.15848874
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15541442
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.14652144
124Leishmaniasis_Homo sapiens_hsa051400.13496900
125Hepatitis B_Homo sapiens_hsa051610.13166482
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11297049
127Histidine metabolism_Homo sapiens_hsa003400.10773711
128Acute myeloid leukemia_Homo sapiens_hsa052210.10721679
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10643661

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