METTL11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.00278223
2skeletal muscle contraction (GO:0003009)8.91455543
3actin-myosin filament sliding (GO:0033275)8.82392777
4muscle filament sliding (GO:0030049)8.82392777
5sarcoplasmic reticulum calcium ion transport (GO:0070296)8.76526670
6skeletal muscle adaptation (GO:0043501)7.68487707
7actin-mediated cell contraction (GO:0070252)7.24908094
8skeletal muscle fiber development (GO:0048741)6.24711681
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.02649637
10actin filament-based movement (GO:0030048)5.62774945
11myotube cell development (GO:0014904)5.46129475
12striated muscle contraction (GO:0006941)5.43292521
13regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.34799540
14regulation of cell communication by electrical coupling (GO:0010649)5.31690732
15response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.31268505
16carnitine shuttle (GO:0006853)5.30868698
17plasma membrane repair (GO:0001778)5.29693535
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.24661060
19creatine metabolic process (GO:0006600)5.19706468
20sarcomere organization (GO:0045214)5.16125193
21otic vesicle formation (GO:0030916)5.11118520
22glycogen catabolic process (GO:0005980)5.10952825
23DNA double-strand break processing (GO:0000729)5.08141857
24striated muscle atrophy (GO:0014891)4.83956315
25glucan catabolic process (GO:0009251)4.75882174
26response to inactivity (GO:0014854)4.59336095
27cardiac left ventricle morphogenesis (GO:0003214)4.55923267
28myofibril assembly (GO:0030239)4.45753547
29respiratory chain complex IV assembly (GO:0008535)4.44053420
30fatty acid transmembrane transport (GO:1902001)4.42855241
31proteasome assembly (GO:0043248)4.41394870
32cellular polysaccharide catabolic process (GO:0044247)4.36796524
33glycogen biosynthetic process (GO:0005978)4.35931399
34glucan biosynthetic process (GO:0009250)4.35931399
35regulation of nuclear cell cycle DNA replication (GO:0033262)4.33441996
36muscle contraction (GO:0006936)4.32776638
37skeletal muscle tissue regeneration (GO:0043403)4.31801353
38response to pheromone (GO:0019236)4.23909381
39response to muscle activity (GO:0014850)4.18180641
40muscle atrophy (GO:0014889)4.16726096
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.10802750
42neuronal action potential propagation (GO:0019227)4.10422101
43polysaccharide catabolic process (GO:0000272)4.08599112
44synapsis (GO:0007129)4.05185812
45dopamine transport (GO:0015872)4.01525866
46heterochromatin organization (GO:0070828)4.00619130
47neuromuscular synaptic transmission (GO:0007274)3.97009575
48striated muscle adaptation (GO:0014888)3.95815211
49carnitine transmembrane transport (GO:1902603)3.91768549
50regulation of meiosis I (GO:0060631)3.90839203
51purine nucleotide salvage (GO:0032261)3.88117540
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.87533208
53presynaptic membrane assembly (GO:0097105)3.84567105
54muscle system process (GO:0003012)3.83663533
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.82297524
56pyrimidine ribonucleoside catabolic process (GO:0046133)3.75835624
57cytochrome complex assembly (GO:0017004)3.75140918
58muscle fiber development (GO:0048747)3.74181983
59cytidine deamination (GO:0009972)3.72479377
60cytidine metabolic process (GO:0046087)3.72479377
61cytidine catabolic process (GO:0006216)3.72479377
62glycogen metabolic process (GO:0005977)3.66124606
63actomyosin structure organization (GO:0031032)3.61352115
64glucan metabolic process (GO:0044042)3.58064376
65cellular glucan metabolic process (GO:0006073)3.58064376
66lactate metabolic process (GO:0006089)3.55530183
67DNA methylation involved in gamete generation (GO:0043046)3.55406841
68amino-acid betaine transport (GO:0015838)3.54912089
69carnitine transport (GO:0015879)3.54912089
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50250622
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.50250622
72NADH dehydrogenase complex assembly (GO:0010257)3.50250622
73DNA demethylation (GO:0080111)3.46850805
74ovulation cycle (GO:0042698)3.43317925
75negative regulation of potassium ion transmembrane transport (GO:1901380)3.38755042
76regulation of calcium ion transmembrane transporter activity (GO:1901019)3.38095194
77regulation of calcium ion transmembrane transport (GO:1903169)3.38095194
78transcription from mitochondrial promoter (GO:0006390)3.29887018
79muscle adaptation (GO:0043500)3.29846255
80negative regulation of protein localization to cell surface (GO:2000009)3.28331616
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27598523
82cardiac muscle contraction (GO:0060048)3.26499029
83negative regulation of skeletal muscle tissue development (GO:0048642)3.26419479
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.21131346
85mitochondrial respiratory chain complex assembly (GO:0033108)3.20150558
86pyrimidine nucleobase catabolic process (GO:0006208)3.19167129
87regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.14518436
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14406687
89muscle cell cellular homeostasis (GO:0046716)3.14400204
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.13895793
91negative regulation of keratinocyte proliferation (GO:0010839)3.12060220
92regulation of relaxation of muscle (GO:1901077)3.11811646
93muscle structure development (GO:0061061)3.11234127
94regulation of membrane repolarization (GO:0060306)3.10141895
95muscle organ development (GO:0007517)3.09552342
96L-serine metabolic process (GO:0006563)3.09169848
97oxidative demethylation (GO:0070989)3.09020911
98regulation of actin filament-based movement (GO:1903115)3.08979245
99negative regulation of membrane potential (GO:0045837)3.08774058
100histone H2A acetylation (GO:0043968)3.07520526
101neuromuscular junction development (GO:0007528)3.05553009
102aspartate family amino acid catabolic process (GO:0009068)3.05191276
103protein complex biogenesis (GO:0070271)3.04976767
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.02789643
105branched-chain amino acid catabolic process (GO:0009083)3.02420989
106positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.01051746
107male meiosis I (GO:0007141)3.00363727
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99587256
109presynaptic membrane organization (GO:0097090)2.99026589
110lysine metabolic process (GO:0006553)2.98440314
111lysine catabolic process (GO:0006554)2.98440314
112adult heart development (GO:0007512)2.97019932
113C4-dicarboxylate transport (GO:0015740)2.95532444
114membrane depolarization during action potential (GO:0086010)2.95505191
115regulation of acyl-CoA biosynthetic process (GO:0050812)2.94500591
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91364898
117regulation of mitotic spindle checkpoint (GO:1903504)2.91364898
118forebrain neuron differentiation (GO:0021879)2.90276736
119striated muscle cell development (GO:0055002)2.88517545
120myotube differentiation (GO:0014902)2.86465539
121negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.85960137
122striatum development (GO:0021756)2.85685158
123behavioral response to cocaine (GO:0048148)2.85538543
124DNA catabolic process, exonucleolytic (GO:0000738)2.84944345
125piRNA metabolic process (GO:0034587)2.83618096
126positive regulation of catecholamine secretion (GO:0033605)2.82936876
127myoblast fusion (GO:0007520)2.82695427
128response to activity (GO:0014823)2.80955404
129regulation of striated muscle contraction (GO:0006942)2.79415745
130regulation of cardioblast differentiation (GO:0051890)2.77832869
131cellular carbohydrate catabolic process (GO:0044275)2.76964364
132response to nitrosative stress (GO:0051409)2.76757525
133negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75831096
134anterior/posterior axis specification, embryo (GO:0008595)2.75691110
135negative regulation of sodium ion transport (GO:0010766)2.74938836
136regulation of cation channel activity (GO:2001257)2.72924442
137negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72173237
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.72173237
139regulation of translation, ncRNA-mediated (GO:0045974)2.72173237
140positive regulation of catenin import into nucleus (GO:0035413)2.70471146
141negative regulation of muscle hypertrophy (GO:0014741)2.69621006
142relaxation of cardiac muscle (GO:0055119)2.69044636
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68923423
144signal peptide processing (GO:0006465)2.68440674
145regulation of glucokinase activity (GO:0033131)2.68296199
146regulation of hexokinase activity (GO:1903299)2.68296199
147IMP metabolic process (GO:0046040)2.67321464
148axonal fasciculation (GO:0007413)2.66324750
149postsynaptic membrane organization (GO:0001941)2.66026252
150tongue development (GO:0043586)2.65953206
151cardiac myofibril assembly (GO:0055003)2.64677580
152negative regulation of potassium ion transport (GO:0043267)2.63597055
153positive regulation of cation channel activity (GO:2001259)2.62819156
154meiosis I (GO:0007127)2.62396659
155regulation of sequestering of calcium ion (GO:0051282)2.60993287
156positive regulation of DNA repair (GO:0045739)2.60795187
157regulation of cofactor metabolic process (GO:0051193)2.60400986
158retina vasculature morphogenesis in camera-type eye (GO:0061299)2.59820462
159protein K11-linked deubiquitination (GO:0035871)2.56627873
160peptidyl-histidine modification (GO:0018202)2.56335048
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53483178
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53252159
163RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53252159
164regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49871647
165behavioral fear response (GO:0001662)2.49573256
166behavioral defense response (GO:0002209)2.49573256
167replication fork processing (GO:0031297)2.49215075
168tachykinin receptor signaling pathway (GO:0007217)2.49092649
169pseudouridine synthesis (GO:0001522)2.46813778
170purine nucleobase biosynthetic process (GO:0009113)2.46591972
171peptidyl-cysteine modification (GO:0018198)2.46017645
172cardiac muscle hypertrophy (GO:0003300)2.45346767
173positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44598331
174regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.44338287
175regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.44338287
176cardiac ventricle morphogenesis (GO:0003208)2.43494529
177negative regulation of systemic arterial blood pressure (GO:0003085)2.42157184
178protein heterotetramerization (GO:0051290)2.41913749
179double-strand break repair via homologous recombination (GO:0000724)2.41080533
180negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40744635
181DNA strand renaturation (GO:0000733)2.40396336
182recombinational repair (GO:0000725)2.39954172
183chromatin remodeling at centromere (GO:0031055)2.38117092
184regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.37313449
185ventricular cardiac muscle cell development (GO:0055015)2.36941576
186exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.34178539
187aldehyde catabolic process (GO:0046185)2.33242350
188nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.32267689
189male meiosis (GO:0007140)2.31914789
190negative regulation of neurological system process (GO:0031645)2.31282477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.97400599
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.70747523
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66382511
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92474230
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.78782403
6* FUS_26573619_Chip-Seq_HEK293_Human2.64594016
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48913234
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.44595204
9TAF15_26573619_Chip-Seq_HEK293_Human2.33249296
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32504692
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29367955
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.25230587
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23177849
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22223709
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.21803363
16IGF1R_20145208_ChIP-Seq_DFB_Human2.18520289
17* P300_19829295_ChIP-Seq_ESCs_Human2.17556520
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.12142722
19AR_21572438_ChIP-Seq_LNCaP_Human2.11908414
20VDR_22108803_ChIP-Seq_LS180_Human2.11283884
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11245090
22DROSHA_22980978_ChIP-Seq_HELA_Human2.09191978
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07007640
24EWS_26573619_Chip-Seq_HEK293_Human2.06408728
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03975950
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02420953
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97738200
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97660383
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95079946
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95079946
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93292852
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91722554
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.91696683
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90771332
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89480944
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86257313
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81092928
38ZNF274_21170338_ChIP-Seq_K562_Hela1.78351041
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74406413
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73210899
41ELK1_19687146_ChIP-ChIP_HELA_Human1.71456775
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70084293
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66601547
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63956283
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.63436944
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62646703
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.60474011
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59829571
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59654544
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.58451122
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56961068
52REST_21632747_ChIP-Seq_MESCs_Mouse1.53407976
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.52492531
54ER_23166858_ChIP-Seq_MCF-7_Human1.51773536
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50555098
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49958867
57E2F7_22180533_ChIP-Seq_HELA_Human1.47011773
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.46775320
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45457324
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43828416
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40792628
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39242237
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.37806359
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37341359
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36242519
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35916732
67TCF4_23295773_ChIP-Seq_U87_Human1.34703673
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.33394188
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32928433
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.32463147
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.31983017
72SOX2_19829295_ChIP-Seq_ESCs_Human1.31518617
73NANOG_19829295_ChIP-Seq_ESCs_Human1.31518617
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30258514
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.30208283
76CTCF_27219007_Chip-Seq_Bcells_Human1.30008296
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.28104548
78KDM2B_26808549_Chip-Seq_K562_Human1.28072120
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26373066
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25886159
81STAT3_23295773_ChIP-Seq_U87_Human1.25366865
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24797960
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24720283
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23723913
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23267696
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.22866958
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.22866958
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22223461
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.21804681
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21389699
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.20345171
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20145032
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20032498
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19833035
95FOXP3_21729870_ChIP-Seq_TREG_Human1.19592848
96* EZH2_27294783_Chip-Seq_NPCs_Mouse1.19215539
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16569436
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16065635
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15637378
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15514842
101TCF4_22108803_ChIP-Seq_LS180_Human1.15289621
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14205662
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.13969991
104TP53_22573176_ChIP-Seq_HFKS_Human1.13413954
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.12677872
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12165980
107MYC_18940864_ChIP-ChIP_HL60_Human1.12031969
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11076263
109RUNX2_22187159_ChIP-Seq_PCA_Human1.09981274
110* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08785265
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07912018
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.07148575
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.06384939
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06018694
115GBX2_23144817_ChIP-Seq_PC3_Human1.05648769
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04542682
117* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04328614
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04195397
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.03994170
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03193770
121MYC_27129775_Chip-Seq_CORNEA_Mouse1.02404799
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02394064
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02339000
124AR_19668381_ChIP-Seq_PC3_Human1.01221746
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99976314
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.99535056
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.99336188
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.99036570
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.98820049
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98609116
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98323793
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98281095
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98281095
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97733985
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.97688787
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97645030
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.97575767
138* CDX2_22108803_ChIP-Seq_LS180_Human0.97348140
139* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96213649
140BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95937085
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95883658
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95053834
143VDR_23849224_ChIP-Seq_CD4+_Human0.95006117
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93974714
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93137396
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92979555
147HTT_18923047_ChIP-ChIP_STHdh_Human0.92705758
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92294999
149LXR_22292898_ChIP-Seq_THP-1_Human0.92169089
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91420541
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.90619132
152CBP_20019798_ChIP-Seq_JUKART_Human0.89611594
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89611594
154BCAT_22108803_ChIP-Seq_LS180_Human0.88298253
155AR_25329375_ChIP-Seq_VCAP_Human0.87556792
156ARNT_22903824_ChIP-Seq_MCF-7_Human0.87362632
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.87221902
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86758125
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86468849
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85567279
161ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85550743
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83335664
163CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81919756
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81750513
165FOXH1_21741376_ChIP-Seq_ESCs_Human0.80529092
166KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80143813
167TP53_18474530_ChIP-ChIP_U2OS_Human0.79233554
168ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79026575
169NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78849814
170NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78849814
171YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78383884
172SMAD4_21741376_ChIP-Seq_EPCs_Human0.77372789
173MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76810706
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76769534
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76621475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.86885482
2MP0003646_muscle_fatigue5.65378823
3MP0000749_muscle_degeneration5.54292060
4MP0000751_myopathy5.49147878
5MP0006292_abnormal_olfactory_placode4.32348428
6MP0004036_abnormal_muscle_relaxation3.70107018
7MP0000747_muscle_weakness3.69676687
8MP0003880_abnormal_central_pattern3.68706943
9MP0002106_abnormal_muscle_physiology3.59603671
10MP0002837_dystrophic_cardiac_calcinosis3.44688983
11MP0004130_abnormal_muscle_cell3.26093619
12MP0000759_abnormal_skeletal_muscle3.26045145
13MP0003136_yellow_coat_color3.14772608
14MP0008877_abnormal_DNA_methylation3.11756140
15MP0002269_muscular_atrophy3.09955776
16MP0004087_abnormal_muscle_fiber3.07001252
17MP0005369_muscle_phenotype2.92874797
18MP0009379_abnormal_foot_pigmentation2.91105953
19MP0005620_abnormal_muscle_contractility2.71370308
20MP0004270_analgesia2.64856568
21MP0008961_abnormal_basal_metabolism2.60060512
22MP0002254_reproductive_system_inflammat2.53869865
23MP0000750_abnormal_muscle_regeneration2.52191505
24MP0002736_abnormal_nociception_after2.47180066
25MP0004233_abnormal_muscle_weight2.37462997
26MP0009384_cardiac_valve_regurgitation2.37013657
27MP0004859_abnormal_synaptic_plasticity2.26824174
28MP0005423_abnormal_somatic_nervous2.21270707
29MP0000579_abnormal_nail_morphology2.06560296
30MP0000537_abnormal_urethra_morphology1.94758639
31MP0002332_abnormal_exercise_endurance1.93437942
32MP0000383_abnormal_hair_follicle1.89379170
33MP0003122_maternal_imprinting1.89318731
34MP0000733_abnormal_muscle_development1.87908119
35MP0001986_abnormal_taste_sensitivity1.67335732
36MP0000372_irregular_coat_pigmentation1.66235106
37MP0002938_white_spotting1.64587241
38MP0005330_cardiomyopathy1.63300416
39MP0004215_abnormal_myocardial_fiber1.60736431
40MP0001293_anophthalmia1.59095705
41MP0003119_abnormal_digestive_system1.58953572
42MP0006138_congestive_heart_failure1.58112397
43MP0004084_abnormal_cardiac_muscle1.57522809
44MP0000013_abnormal_adipose_tissue1.54884321
45MP0002163_abnormal_gland_morphology1.51777754
46MP0008058_abnormal_DNA_repair1.50957190
47MP0000427_abnormal_hair_cycle1.48280224
48MP0010094_abnormal_chromosome_stability1.48216976
49MP0000566_synostosis1.47380479
50MP0005551_abnormal_eye_electrophysiolog1.45948440
51MP0010307_abnormal_tumor_latency1.40660866
52MP0004957_abnormal_blastocyst_morpholog1.39599024
53MP0008789_abnormal_olfactory_epithelium1.39395968
54MP0005253_abnormal_eye_physiology1.38963146
55MP0006072_abnormal_retinal_apoptosis1.36525887
56MP0002108_abnormal_muscle_morphology1.36495578
57MP0000516_abnormal_urinary_system1.34201148
58MP0005367_renal/urinary_system_phenotyp1.34201148
59MP0006036_abnormal_mitochondrial_physio1.33959915
60MP0001849_ear_inflammation1.33789799
61MP0004185_abnormal_adipocyte_glucose1.33504656
62MP0003693_abnormal_embryo_hatching1.32372417
63MP0001440_abnormal_grooming_behavior1.28484972
64MP0002972_abnormal_cardiac_muscle1.26589942
65MP0003718_maternal_effect1.26113039
66MP0002233_abnormal_nose_morphology1.24921809
67MP0002971_abnormal_brown_adipose1.22888362
68MP0004484_altered_response_of1.21789262
69MP0000538_abnormal_urinary_bladder1.21440386
70MP0001968_abnormal_touch/_nociception1.21227821
71MP0010678_abnormal_skin_adnexa1.21074276
72MP0001764_abnormal_homeostasis1.17946845
73MP0004142_abnormal_muscle_tone1.14063426
74MP0002160_abnormal_reproductive_system1.12664536
75MP0006054_spinal_hemorrhage1.12298176
76MP0008057_abnormal_DNA_replication1.12141801
77MP0005266_abnormal_metabolism1.11895198
78MP0001346_abnormal_lacrimal_gland1.09696729
79MP0005666_abnormal_adipose_tissue1.07727886
80MP0002063_abnormal_learning/memory/cond1.07547047
81MP0005645_abnormal_hypothalamus_physiol1.07491817
82MP0008995_early_reproductive_senescence1.06109816
83MP0000778_abnormal_nervous_system1.05005382
84MP0003937_abnormal_limbs/digits/tail_de1.04787894
85MP0003635_abnormal_synaptic_transmissio1.03636368
86MP0001177_atelectasis1.03602017
87MP0006276_abnormal_autonomic_nervous0.99619968
88MP0010630_abnormal_cardiac_muscle0.98426887
89MP0003137_abnormal_impulse_conducting0.95937937
90MP0000647_abnormal_sebaceous_gland0.95123785
91MP0009745_abnormal_behavioral_response0.94478202
92MP0005375_adipose_tissue_phenotype0.93068227
93MP0005646_abnormal_pituitary_gland0.91614772
94MP0006035_abnormal_mitochondrial_morpho0.90455211
95MP0004147_increased_porphyrin_level0.90199180
96MP0001501_abnormal_sleep_pattern0.89920918
97MP0008569_lethality_at_weaning0.89883840
98MP0004264_abnormal_extraembryonic_tissu0.88538183
99MP0001286_abnormal_eye_development0.88494049
100MP0004134_abnormal_chest_morphology0.88194577
101MP0002210_abnormal_sex_determination0.87923451
102MP0002697_abnormal_eye_size0.86045993
103MP0005391_vision/eye_phenotype0.85463893
104MP0000631_abnormal_neuroendocrine_gland0.84390780
105MP0003567_abnormal_fetal_cardiomyocyte0.83852854
106MP0003890_abnormal_embryonic-extraembry0.83005482
107MP0008872_abnormal_physiological_respon0.82531582
108MP0003221_abnormal_cardiomyocyte_apopto0.81645353
109MP0003938_abnormal_ear_development0.81015948
110MP0001529_abnormal_vocalization0.80458176
111MP0002822_catalepsy0.80426911
112MP0002064_seizures0.79155124
113MP0009053_abnormal_anal_canal0.78259159
114MP0001929_abnormal_gametogenesis0.78072898
115MP0001502_abnormal_circadian_rhythm0.77695458
116MP0005394_taste/olfaction_phenotype0.77191695
117MP0005499_abnormal_olfactory_system0.77191695
118MP0001544_abnormal_cardiovascular_syste0.76327341
119MP0005385_cardiovascular_system_phenoty0.76327341
120MP0003786_premature_aging0.76248513
121MP0005395_other_phenotype0.76083547
122MP0003186_abnormal_redox_activity0.76052789
123MP0008007_abnormal_cellular_replicative0.74794927
124MP0003077_abnormal_cell_cycle0.74766087
125MP0000003_abnormal_adipose_tissue0.74677138
126MP0009672_abnormal_birth_weight0.73877031
127MP0001984_abnormal_olfaction0.72906280
128MP0003879_abnormal_hair_cell0.70697796
129MP0004133_heterotaxia0.70597052
130MP0002734_abnormal_mechanical_nocicepti0.70240108
131MP0002095_abnormal_skin_pigmentation0.69320244
132MP0002272_abnormal_nervous_system0.68518664
133MP0003656_abnormal_erythrocyte_physiolo0.66806148
134MP0002127_abnormal_cardiovascular_syste0.65811956
135MP0010030_abnormal_orbit_morphology0.64879216
136MP0003329_amyloid_beta_deposits0.63371508
137MP0002638_abnormal_pupillary_reflex0.63294845
138MP0002066_abnormal_motor_capabilities/c0.62917110
139MP0005535_abnormal_body_temperature0.62614733
140MP0003950_abnormal_plasma_membrane0.61573138
141MP0002557_abnormal_social/conspecific_i0.61148816
142MP0005334_abnormal_fat_pad0.60530552
143MP0005248_abnormal_Harderian_gland0.60474292
144MP0002078_abnormal_glucose_homeostasis0.59891471
145MP0001299_abnormal_eye_distance/0.58900917
146MP0004085_abnormal_heartbeat0.58889142
147MP0002234_abnormal_pharynx_morphology0.58400798
148MP0005670_abnormal_white_adipose0.58295431
149MP0004858_abnormal_nervous_system0.58234289
150MP0002067_abnormal_sensory_capabilities0.56834687
151MP0008775_abnormal_heart_ventricle0.56679365
152MP0002733_abnormal_thermal_nociception0.56637593
153MP0003828_pulmonary_edema0.56486324
154MP0004811_abnormal_neuron_physiology0.55029531
155MP0001486_abnormal_startle_reflex0.51917617
156MP0002572_abnormal_emotion/affect_behav0.51842208
157MP0000920_abnormal_myelination0.51182359
158MP0002909_abnormal_adrenal_gland0.50889780
159MP0005584_abnormal_enzyme/coenzyme_acti0.50791252
160MP0003121_genomic_imprinting0.50499953
161MP0009250_abnormal_appendicular_skeleto0.50192707
162MP0003948_abnormal_gas_homeostasis0.50144024
163MP0005452_abnormal_adipose_tissue0.48695840
164MP0004043_abnormal_pH_regulation0.47843564
165MP0005187_abnormal_penis_morphology0.47774669
166MP0003075_altered_response_to0.46680321
167MP0002882_abnormal_neuron_morphology0.46021033
168MP0001485_abnormal_pinna_reflex0.45626574

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.85122119
2Exercise-induced myalgia (HP:0003738)8.60252822
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.44255738
4Nemaline bodies (HP:0003798)7.85354767
5Exercise-induced muscle cramps (HP:0003710)7.73759626
6Muscle hypertrophy of the lower extremities (HP:0008968)6.88016441
7Type 1 muscle fiber predominance (HP:0003803)6.26993830
8Distal arthrogryposis (HP:0005684)6.06218279
9Calf muscle hypertrophy (HP:0008981)6.06140260
10Myopathic facies (HP:0002058)5.84188788
11Round ear (HP:0100830)5.49331968
12Myoglobinuria (HP:0002913)5.30536212
13Difficulty running (HP:0009046)5.18377780
14Ulnar deviation of the wrist (HP:0003049)4.83484892
15Muscle stiffness (HP:0003552)4.67402047
16Muscle fiber splitting (HP:0003555)4.63020337
17Hyporeflexia of lower limbs (HP:0002600)4.49520127
18EMG: myopathic abnormalities (HP:0003458)4.33081513
19Rhabdomyolysis (HP:0003201)4.31066352
20Calcaneovalgus deformity (HP:0001848)4.29071557
21Myotonia (HP:0002486)4.06120540
22Absent phalangeal crease (HP:0006109)4.03530845
23Abnormality of the calf musculature (HP:0001430)4.02929206
24Deformed tarsal bones (HP:0008119)3.87112850
25Increased connective tissue (HP:0009025)3.85550140
263-Methylglutaconic aciduria (HP:0003535)3.73303826
27Abnormal finger flexion creases (HP:0006143)3.52326234
28Acute necrotizing encephalopathy (HP:0006965)3.49513857
29Malignant hyperthermia (HP:0002047)3.49135711
30Abnormality of the labia minora (HP:0012880)3.46504003
31Sudden death (HP:0001699)3.33800723
32Difficulty climbing stairs (HP:0003551)3.31285128
33Subaortic stenosis (HP:0001682)3.27827058
34Abnormality of the left ventricular outflow tract (HP:0011103)3.27827058
35Abnormality of skeletal muscle fiber size (HP:0012084)3.23725141
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.22450417
37Abnormality of alanine metabolism (HP:0010916)3.22450417
38Hyperalaninemia (HP:0003348)3.22450417
39Shoulder girdle muscle weakness (HP:0003547)3.20676115
40Atonic seizures (HP:0010819)3.18781670
41Progressive macrocephaly (HP:0004481)3.16683116
42Pelvic girdle muscle weakness (HP:0003749)3.15928931
43Acute encephalopathy (HP:0006846)3.15116091
44Abnormal mitochondria in muscle tissue (HP:0008316)3.08255656
45Rimmed vacuoles (HP:0003805)3.05762541
46Abnormality of the musculature of the pelvis (HP:0001469)3.03418772
47Abnormality of the hip-girdle musculature (HP:0001445)3.03418772
48Neck muscle weakness (HP:0000467)3.03084553
49Increased variability in muscle fiber diameter (HP:0003557)2.98072903
50Focal motor seizures (HP:0011153)2.93736133
51Hyperglycinuria (HP:0003108)2.93693091
52Oligomenorrhea (HP:0000876)2.93187690
53Asymmetric septal hypertrophy (HP:0001670)2.90571404
54Pendular nystagmus (HP:0012043)2.87280777
55Hyperkalemia (HP:0002153)2.86650739
56Volvulus (HP:0002580)2.86572898
57Abnormality of serine family amino acid metabolism (HP:0010894)2.80555402
58Abnormality of glycine metabolism (HP:0010895)2.80555402
59Increased CSF lactate (HP:0002490)2.79678354
60Glioma (HP:0009733)2.79216979
61Frequent falls (HP:0002359)2.70967156
62Bifid tongue (HP:0010297)2.64624714
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.64007191
64Areflexia of lower limbs (HP:0002522)2.62252396
65Abnormality of macular pigmentation (HP:0008002)2.61408641
66Abnormality of serum amino acid levels (HP:0003112)2.59793207
67Abnormality of the astrocytes (HP:0100707)2.57450490
68Astrocytoma (HP:0009592)2.57450490
69Pancreatic fibrosis (HP:0100732)2.56732248
70Ectopic kidney (HP:0000086)2.56201321
71Intestinal atresia (HP:0011100)2.50242013
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49304338
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.48937471
74Pancreatic cysts (HP:0001737)2.48791518
75Ependymoma (HP:0002888)2.48583924
76Birth length less than 3rd percentile (HP:0003561)2.45759680
77Abnormality of the calcaneus (HP:0008364)2.44729735
78Polyphagia (HP:0002591)2.41984966
79EMG: neuropathic changes (HP:0003445)2.39553803
80Abnormality of the neuromuscular junction (HP:0003398)2.38619691
81Fatigable weakness (HP:0003473)2.38619691
82Failure to thrive in infancy (HP:0001531)2.37014671
83Ventricular tachycardia (HP:0004756)2.36389040
84Hyperglycinemia (HP:0002154)2.35940153
85Hyperventilation (HP:0002883)2.34190494
86Cerebral edema (HP:0002181)2.32337352
87Septo-optic dysplasia (HP:0100842)2.31635588
88True hermaphroditism (HP:0010459)2.31538925
89Molar tooth sign on MRI (HP:0002419)2.31286969
90Abnormality of midbrain morphology (HP:0002418)2.31286969
91Mitochondrial inheritance (HP:0001427)2.30646814
92Hepatocellular necrosis (HP:0001404)2.29927191
93Severe visual impairment (HP:0001141)2.28909752
94Shawl scrotum (HP:0000049)2.28301157
95Type I transferrin isoform profile (HP:0003642)2.26443844
96Muscular dystrophy (HP:0003560)2.24995550
97Limb-girdle muscle weakness (HP:0003325)2.24248847
98Horizontal nystagmus (HP:0000666)2.24247577
99Hepatic necrosis (HP:0002605)2.22961331
100Hypoplastic ischia (HP:0003175)2.22624246
101Nephronophthisis (HP:0000090)2.20426110
102Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19883388
103Distal lower limb muscle weakness (HP:0009053)2.18928906
104Abnormality of chromosome stability (HP:0003220)2.17693852
105Occipital encephalocele (HP:0002085)2.15341108
106Paralysis (HP:0003470)2.15209256
107Colon cancer (HP:0003003)2.15003346
108Hemiparesis (HP:0001269)2.11269093
109Proximal amyotrophy (HP:0007126)2.10969599
110Chromsome breakage (HP:0040012)2.08705297
111Slender build (HP:0001533)2.08466752
112Absent radius (HP:0003974)2.08177477
113Bile duct proliferation (HP:0001408)2.08000561
114Abnormal biliary tract physiology (HP:0012439)2.08000561
115Atrial fibrillation (HP:0005110)2.07133330
116Nonprogressive disorder (HP:0003680)2.06361820
117Gowers sign (HP:0003391)2.04294832
118Centrally nucleated skeletal muscle fibers (HP:0003687)2.03465801
119Microglossia (HP:0000171)2.03040820
120Gastrointestinal atresia (HP:0002589)2.02271002
121Stomach cancer (HP:0012126)2.01655952
122Meckel diverticulum (HP:0002245)2.00292252
123Limb-girdle muscle atrophy (HP:0003797)1.99967733
124Increased serum lactate (HP:0002151)1.98969632
125Mildly elevated creatine phosphokinase (HP:0008180)1.98594930
126Stenosis of the external auditory canal (HP:0000402)1.96299797
127Preaxial foot polydactyly (HP:0001841)1.95707209
128Tetraplegia (HP:0002445)1.95685684
129Aplasia involving forearm bones (HP:0009822)1.93047125
130Absent forearm bone (HP:0003953)1.93047125
131Stridor (HP:0010307)1.92762329
132Renal hypoplasia (HP:0000089)1.92100903
133Abnormality of the ischium (HP:0003174)1.91135721
134Abnormality of the shoulder girdle musculature (HP:0001435)1.90400637
135Abnormality of the preputium (HP:0100587)1.90143814
136X-linked dominant inheritance (HP:0001423)1.90084622
137Dialeptic seizures (HP:0011146)1.89196512
138Generalized muscle weakness (HP:0003324)1.88930464
139Sclerocornea (HP:0000647)1.88296004
140Abnormality of the ileum (HP:0001549)1.85679761
141Scapular winging (HP:0003691)1.85414149
142Fetal akinesia sequence (HP:0001989)1.85092365
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.85063957
144Optic disc pallor (HP:0000543)1.84956691
145Ulnar deviation of finger (HP:0009465)1.84614332
146Erythroderma (HP:0001019)1.83853213
147Cerebellar dysplasia (HP:0007033)1.83185619
148Pancreatic islet-cell hyperplasia (HP:0004510)1.82452177
149Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81555784
150Lactic acidosis (HP:0003128)1.80915309
151Preaxial hand polydactyly (HP:0001177)1.76307471
152Weak cry (HP:0001612)1.76210250
153Supraventricular tachycardia (HP:0004755)1.75377269
154Impaired vibration sensation in the lower limbs (HP:0002166)1.74925714
155Primary atrial arrhythmia (HP:0001692)1.74508135
156Bundle branch block (HP:0011710)1.74443241
157Right ventricular cardiomyopathy (HP:0011663)1.72687779
158Supraventricular arrhythmia (HP:0005115)1.72572927
159Small hand (HP:0200055)1.72265302
160Abnormality of the renal medulla (HP:0100957)1.71864601
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71816343
162Abnormal protein N-linked glycosylation (HP:0012347)1.71816343
163Abnormal protein glycosylation (HP:0012346)1.71816343
164Abnormal glycosylation (HP:0012345)1.71816343
165Amelogenesis imperfecta (HP:0000705)1.70200468
166Postaxial foot polydactyly (HP:0001830)1.69834491
167Generalized tonic-clonic seizures (HP:0002069)1.69367989
168Bulbar palsy (HP:0001283)1.67987132
169Waddling gait (HP:0002515)1.65216532
170Abnormal eating behavior (HP:0100738)1.64601170
171Increased purine levels (HP:0004368)1.64070780
172Hyperuricemia (HP:0002149)1.64070780
173Distal lower limb amyotrophy (HP:0008944)1.62960106
174Ankle clonus (HP:0011448)1.62195377
175Achilles tendon contracture (HP:0001771)1.62186381
176Urinary urgency (HP:0000012)1.61365983
177Increased serum pyruvate (HP:0003542)1.59115451
178Abnormality of glycolysis (HP:0004366)1.59115451
179Metatarsus adductus (HP:0001840)1.59050393
180Focal seizures (HP:0007359)1.51893954
181Tarsal synostosis (HP:0008368)1.50150295
182Dilated cardiomyopathy (HP:0001644)1.49955595
183Spinal rigidity (HP:0003306)1.49203667
184Gout (HP:0001997)1.48453533
185Abnormality of the Achilles tendon (HP:0005109)1.48403279
186Progressive muscle weakness (HP:0003323)1.48050938
187Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.47724846
188Facial diplegia (HP:0001349)1.47693607
189Increased density of long bones (HP:0006392)1.47678417
190Abnormality of the pubic bones (HP:0003172)1.47528263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.86901104
2OBSCN5.71665048
3PHKG14.90637692
4PHKG24.90637692
5TTN4.44847929
6FRK3.66824915
7ZAK3.50142723
8PBK3.49060713
9ERBB43.22430428
10FGFR23.14575512
11WNK32.96040852
12CASK2.78304033
13PNCK2.74751306
14NME12.64444688
15TTK2.58822953
16STK162.49515697
17MAP2K42.43910622
18LATS12.43258329
19FGFR42.36495187
20TRIB32.21106709
21TRIM282.17368626
22NTRK22.13046521
23TYRO32.12760823
24MAP3K122.07898946
25PINK12.04861138
26STK38L1.87879163
27PIK3CG1.85003499
28DMPK1.78719818
29PLK21.65648861
30UHMK11.62473042
31BUB11.60557363
32NUAK11.58540000
33MAP3K71.58340136
34PLK31.52923979
35NEK11.52104380
36EIF2AK31.51936414
37TNIK1.50889266
38PAK61.44447978
39VRK21.43664158
40PDGFRA1.32591765
41SRPK11.27500129
42MET1.26760740
43MARK11.26735411
44MUSK1.26042539
45MAP2K31.21219978
46FGFR31.14947617
47NLK1.14786660
48MAP3K41.11304475
49PIK3CA1.09334257
50MAPK121.07503891
51MAP2K61.02750174
52CDK30.99559052
53MAP3K60.97562299
54IRAK20.95324188
55MKNK20.92076623
56PDK40.91338716
57PDK30.91338716
58MAP3K110.90325585
59PLK10.87961937
60CDK190.87707507
61TSSK60.87027143
62PRPF4B0.86533828
63OXSR10.85269627
64PRKCE0.82657542
65SIK30.81501404
66CAMK1G0.80455472
67NEK20.79885661
68ATR0.78779926
69MST40.73870845
70IRAK10.73449066
71CSNK1G10.70950262
72BCR0.70518161
73ERBB30.69958143
74RET0.69894872
75ERBB20.69548962
76MAPK130.69130093
77TAOK20.69114052
78NTRK30.67873895
79BRSK20.67592337
80RIPK10.67209971
81KSR10.66500293
82PLK40.64968102
83CLK10.63731810
84BCKDK0.63338660
85TESK10.62570141
86GRK10.62259538
87BMPR1B0.62116507
88ITK0.61887975
89ATM0.61321166
90MINK10.60208851
91CHEK20.59060776
92PASK0.57576603
93MARK30.56855303
94VRK10.56836410
95PRKAA20.56054330
96FGFR10.55511787
97PRKAA10.54836732
98MAPKAPK30.54732084
99MAPKAPK50.54141385
100DDR20.53789982
101MAP2K70.53781499
102FER0.53584251
103EPHB20.52607861
104CDC70.52110979
105MAP3K50.51685816
106STK40.51091837
107MAP2K20.49194749
108CAMK2D0.48334512
109ADRBK10.47710748
110MKNK10.47067504
111ADRBK20.46911478
112AKT20.43866098
113PDK20.43793713
114EIF2AK20.41978413
115SIK20.41809944
116INSRR0.41028048
117CDK50.40758152
118ICK0.39923086
119STK390.39565769
120CAMK2G0.39133417
121EPHA40.38232077
122CSNK1G30.38035275
123CSNK1A1L0.38005326
124ALK0.37861637
125MAPK40.37372643
126SGK10.37027936
127PRKD10.36499956
128WEE10.36341721
129MAP4K20.36051452
130STK30.35839089
131LIMK10.35620751
132TAF10.34856333
133ROCK10.34274932
134CHEK10.33381386
135PAK30.33310833
136EPHB10.33296719
137PRKCI0.32801507
138DYRK20.31729720
139CDK180.30947668
140LATS20.30697633
141TGFBR10.30263659
142EGFR0.30043803
143PKN10.29821524
144PRKACB0.29747034
145CSNK1D0.29637085
146TGFBR20.29450064
147MYLK0.29376746
148PRKDC0.29298727
149ILK0.28662016
150MAP3K10.28197947
151TRPM70.26976766
152CDK150.26363912
153CDK11A0.26264258
154CDK140.25936814
155PDPK10.24817608
156RPS6KA30.24336771
157SIK10.24107571
158CAMK2B0.22556989
159MARK20.21967374
160BMX0.21684094
161CAMK2A0.21247621
162LRRK20.20805970
163PDGFRB0.20687669
164PDK10.20624025
165PRKACG0.20463716
166CAMKK20.18795620
167MAPK110.17318835
168HCK0.17297589
169PRKCG0.16248466
170PRKD30.15084515
171PRKACA0.14760834
172CAMK10.14269172

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.24757844
2Proteasome_Homo sapiens_hsa030503.09689806
3Circadian rhythm_Homo sapiens_hsa047103.08720244
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.04140684
5Cardiac muscle contraction_Homo sapiens_hsa042602.95236837
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.74438937
7Dilated cardiomyopathy_Homo sapiens_hsa054142.73225348
8Selenocompound metabolism_Homo sapiens_hsa004502.63357695
9RNA polymerase_Homo sapiens_hsa030202.54606773
10Nitrogen metabolism_Homo sapiens_hsa009102.51459705
11Homologous recombination_Homo sapiens_hsa034402.46666063
12One carbon pool by folate_Homo sapiens_hsa006702.17067501
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12391885
14Oxytocin signaling pathway_Homo sapiens_hsa049212.11818442
15Fanconi anemia pathway_Homo sapiens_hsa034601.91211768
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85652443
17Propanoate metabolism_Homo sapiens_hsa006401.81740230
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80253988
19Calcium signaling pathway_Homo sapiens_hsa040201.79217060
20Phototransduction_Homo sapiens_hsa047441.74927435
21Collecting duct acid secretion_Homo sapiens_hsa049661.73136706
22Basal transcription factors_Homo sapiens_hsa030221.72589396
23Fatty acid elongation_Homo sapiens_hsa000621.71920067
24Starch and sucrose metabolism_Homo sapiens_hsa005001.69681822
25Insulin signaling pathway_Homo sapiens_hsa049101.69460593
26Glucagon signaling pathway_Homo sapiens_hsa049221.68610412
27Insulin resistance_Homo sapiens_hsa049311.64086134
28RNA degradation_Homo sapiens_hsa030181.61677871
29Non-homologous end-joining_Homo sapiens_hsa034501.61188508
30Huntingtons disease_Homo sapiens_hsa050161.60018952
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.57504057
32Mismatch repair_Homo sapiens_hsa034301.56191013
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.51855915
34Fatty acid degradation_Homo sapiens_hsa000711.41353734
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40751341
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37492049
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37099139
38Insulin secretion_Homo sapiens_hsa049111.35333395
39Tryptophan metabolism_Homo sapiens_hsa003801.29717448
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.26863372
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25028158
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24772073
43Fatty acid metabolism_Homo sapiens_hsa012121.24735928
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24455960
45Carbon metabolism_Homo sapiens_hsa012001.23578133
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21836533
47Circadian entrainment_Homo sapiens_hsa047131.20137244
48AMPK signaling pathway_Homo sapiens_hsa041521.18419316
49Nucleotide excision repair_Homo sapiens_hsa034201.18395419
50Viral myocarditis_Homo sapiens_hsa054161.17814468
51Lysine degradation_Homo sapiens_hsa003101.16938672
52GABAergic synapse_Homo sapiens_hsa047271.16710037
53GnRH signaling pathway_Homo sapiens_hsa049121.16368589
54Renin secretion_Homo sapiens_hsa049241.14546437
55Ether lipid metabolism_Homo sapiens_hsa005651.12820337
56Folate biosynthesis_Homo sapiens_hsa007901.12066520
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11451644
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11161477
59Arginine biosynthesis_Homo sapiens_hsa002201.10841826
60DNA replication_Homo sapiens_hsa030301.09141328
61Protein export_Homo sapiens_hsa030601.08680110
62Steroid biosynthesis_Homo sapiens_hsa001001.07952351
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.07000019
64Fatty acid biosynthesis_Homo sapiens_hsa000611.06301306
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05646775
66Galactose metabolism_Homo sapiens_hsa000521.05488672
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04928272
68Pyrimidine metabolism_Homo sapiens_hsa002401.02946146
69Gastric acid secretion_Homo sapiens_hsa049711.01804287
70Alzheimers disease_Homo sapiens_hsa050100.99405289
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98017215
72Parkinsons disease_Homo sapiens_hsa050120.97422676
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96281052
74Purine metabolism_Homo sapiens_hsa002300.95892321
75Cell cycle_Homo sapiens_hsa041100.95482379
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94702476
77Cholinergic synapse_Homo sapiens_hsa047250.94026367
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93383864
79MAPK signaling pathway_Homo sapiens_hsa040100.91117400
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90079082
81RNA transport_Homo sapiens_hsa030130.88024719
82Histidine metabolism_Homo sapiens_hsa003400.87179997
83VEGF signaling pathway_Homo sapiens_hsa043700.87011938
84Type II diabetes mellitus_Homo sapiens_hsa049300.86454334
85Taste transduction_Homo sapiens_hsa047420.86439801
86Tight junction_Homo sapiens_hsa045300.84421377
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83384861
88Oxidative phosphorylation_Homo sapiens_hsa001900.83146327
89mTOR signaling pathway_Homo sapiens_hsa041500.82620426
90Butanoate metabolism_Homo sapiens_hsa006500.81135758
91Dopaminergic synapse_Homo sapiens_hsa047280.80629053
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.80577994
93Glutamatergic synapse_Homo sapiens_hsa047240.80504179
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80442222
95ErbB signaling pathway_Homo sapiens_hsa040120.80415287
96Metabolic pathways_Homo sapiens_hsa011000.79191381
97Morphine addiction_Homo sapiens_hsa050320.79032783
98Axon guidance_Homo sapiens_hsa043600.78231578
99Nicotine addiction_Homo sapiens_hsa050330.78198764
100Retinol metabolism_Homo sapiens_hsa008300.77064862
101Glycerolipid metabolism_Homo sapiens_hsa005610.76848637
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76711141
103Linoleic acid metabolism_Homo sapiens_hsa005910.72734982
104Serotonergic synapse_Homo sapiens_hsa047260.69503819
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68850194
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68592983
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68400029
108Arginine and proline metabolism_Homo sapiens_hsa003300.67442013
109Pyruvate metabolism_Homo sapiens_hsa006200.66206389
110Long-term potentiation_Homo sapiens_hsa047200.65306194
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65249512
112Fructose and mannose metabolism_Homo sapiens_hsa000510.64779875
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64398341
114TGF-beta signaling pathway_Homo sapiens_hsa043500.63958652
115Peroxisome_Homo sapiens_hsa041460.63903039
116Biosynthesis of amino acids_Homo sapiens_hsa012300.63753951
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63433890
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63129679
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62972754
120Focal adhesion_Homo sapiens_hsa045100.62912259
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62741416
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61065149
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60864074
124Base excision repair_Homo sapiens_hsa034100.60478693
125Long-term depression_Homo sapiens_hsa047300.59615160
126Adherens junction_Homo sapiens_hsa045200.57802362
127Oocyte meiosis_Homo sapiens_hsa041140.57453432
128Choline metabolism in cancer_Homo sapiens_hsa052310.57451072
129Sphingolipid metabolism_Homo sapiens_hsa006000.56479441
130Amphetamine addiction_Homo sapiens_hsa050310.55924839
131Synaptic vesicle cycle_Homo sapiens_hsa047210.55328052
132PPAR signaling pathway_Homo sapiens_hsa033200.54624097
133Spliceosome_Homo sapiens_hsa030400.54377755
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54257576
135Gap junction_Homo sapiens_hsa045400.53750148
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.52883844
137cAMP signaling pathway_Homo sapiens_hsa040240.52300073
138Sulfur relay system_Homo sapiens_hsa041220.52113780
139Tyrosine metabolism_Homo sapiens_hsa003500.51750797
140FoxO signaling pathway_Homo sapiens_hsa040680.51390725
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50844030
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50202301
143Fat digestion and absorption_Homo sapiens_hsa049750.50017860
144N-Glycan biosynthesis_Homo sapiens_hsa005100.49010187
145Cocaine addiction_Homo sapiens_hsa050300.46817409
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46763267
147Glioma_Homo sapiens_hsa052140.46677363
148Olfactory transduction_Homo sapiens_hsa047400.46610560
149Glutathione metabolism_Homo sapiens_hsa004800.44750343
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.43147480
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.43065450
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42925330
153Proteoglycans in cancer_Homo sapiens_hsa052050.42847864
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39541030
155Salivary secretion_Homo sapiens_hsa049700.38616567
156Sulfur metabolism_Homo sapiens_hsa009200.38219057
157Ras signaling pathway_Homo sapiens_hsa040140.38089230
158Renal cell carcinoma_Homo sapiens_hsa052110.38067307
159beta-Alanine metabolism_Homo sapiens_hsa004100.37550551
160Phenylalanine metabolism_Homo sapiens_hsa003600.37494709
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.35663569
162HIF-1 signaling pathway_Homo sapiens_hsa040660.35627192
163Dorso-ventral axis formation_Homo sapiens_hsa043200.35105289
164Melanogenesis_Homo sapiens_hsa049160.34473777
165Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34129476
166Chemical carcinogenesis_Homo sapiens_hsa052040.32807822
167Drug metabolism - other enzymes_Homo sapiens_hsa009830.32800179

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