ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sulfation (GO:0051923)	7.68843508
2	regulation of somitogenesis (GO:0014807)	6.49255721
3	otic vesicle formation (GO:0030916)	5.57300950
4	hair cycle (GO:0042633)	5.34006806
5	molting cycle (GO:0042303)	5.34006806
6	protein prenylation (GO:0018342)	5.09044703
7	prenylation (GO:0097354)	5.09044703
8	replicative senescence (GO:0090399)	5.07629091
9	DNA replication-dependent nucleosome assembly (GO:0006335)	4.28588315
10	DNA replication-dependent nucleosome organization (GO:0034723)	4.28588315
11	NADH dehydrogenase complex assembly (GO:0010257)	4.21034163
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.21034163
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.21034163
14	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.05360015
15	negative regulation of systemic arterial blood pressure (GO:0003085)	4.00095416
16	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.95538329
17	viral mRNA export from host cell nucleus (GO:0046784)	3.91895471
18	cell proliferation in forebrain (GO:0021846)	3.72997998
19	leukotriene biosynthetic process (GO:0019370)	3.65855556
20	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.65473344
21	mesonephros development (GO:0001823)	3.60886897
22	prostate gland growth (GO:0060736)	3.59225083
23	hematopoietic stem cell proliferation (GO:0071425)	3.58057836
24	peristalsis (GO:0030432)	3.51698470
25	dorsal/ventral axis specification (GO:0009950)	3.46308267
26	forebrain neuron development (GO:0021884)	3.46127116
27	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.45880269
28	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.45880269
29	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.41690800
30	positive regulation of digestive system process (GO:0060456)	3.37942680
31	dermatan sulfate biosynthetic process (GO:0030208)	3.33154140
32	protein complex biogenesis (GO:0070271)	3.30904471
33	cAMP biosynthetic process (GO:0006171)	3.28446947
34	interkinetic nuclear migration (GO:0022027)	3.27822662
35	regulation of skeletal muscle contraction (GO:0014819)	3.18854219
36	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.12579933
37	behavioral response to nicotine (GO:0035095)	3.12490714
38	protein K11-linked deubiquitination (GO:0035871)	3.08759082
39	fucose catabolic process (GO:0019317)	3.08138294
40	L-fucose metabolic process (GO:0042354)	3.08138294
41	L-fucose catabolic process (GO:0042355)	3.08138294
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.06861258
43	regulation of DNA damage checkpoint (GO:2000001)	3.06778173
44	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	3.00537380
45	one-carbon compound transport (GO:0019755)	2.99226011
46	positive regulation of gastrulation (GO:2000543)	2.94700503
47	post-anal tail morphogenesis (GO:0036342)	2.94228176
48	transepithelial transport (GO:0070633)	2.93443080
49	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.92763163
50	flavonoid metabolic process (GO:0009812)	2.91146480
51	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.90088394
52	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.89576417
53	anterior/posterior axis specification, embryo (GO:0008595)	2.87855412
54	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.87038901
55	dermatan sulfate metabolic process (GO:0030205)	2.86011491
56	DNA integration (GO:0015074)	2.82465511
57	lymphangiogenesis (GO:0001946)	2.81889270
58	embryonic hindlimb morphogenesis (GO:0035116)	2.81592237
59	embryonic digit morphogenesis (GO:0042733)	2.81237131
60	positive regulation of cAMP-mediated signaling (GO:0043950)	2.77516144
61	forebrain morphogenesis (GO:0048853)	2.76730566
62	T cell mediated immunity (GO:0002456)	2.74801934
63	negative regulation of DNA repair (GO:0045738)	2.74696069
64	negative regulation of sodium ion transport (GO:0010766)	2.73867872
65	pharyngeal system development (GO:0060037)	2.72621651
66	positive regulation of fatty acid oxidation (GO:0046321)	2.68729220
67	positive regulation of RNA splicing (GO:0033120)	2.68078569
68	histone-serine phosphorylation (GO:0035404)	2.65480491
69	tryptophan metabolic process (GO:0006568)	2.64393744
70	regulation of cell proliferation involved in kidney development (GO:1901722)	2.64355760
71	protein polyglutamylation (GO:0018095)	2.62925832
72	termination of RNA polymerase I transcription (GO:0006363)	2.59983931
73	pericardium development (GO:0060039)	2.57697613
74	magnesium ion transport (GO:0015693)	2.57190745
75	viral transcription (GO:0019083)	2.57061050
76	negative regulation of astrocyte differentiation (GO:0048712)	2.54660269
77	phasic smooth muscle contraction (GO:0014821)	2.53322824
78	protein K48-linked deubiquitination (GO:0071108)	2.51882468
79	striatum development (GO:0021756)	2.51480757
80	activation of protein kinase A activity (GO:0034199)	2.47268259
81	labyrinthine layer development (GO:0060711)	2.45156581
82	hindlimb morphogenesis (GO:0035137)	2.42847093
83	organ induction (GO:0001759)	2.42170189
84	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.41356744
85	innate immune response in mucosa (GO:0002227)	2.40769982
86	cilium or flagellum-dependent cell motility (GO:0001539)	2.40100785
87	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	2.39802281
88	regulation of phospholipid biosynthetic process (GO:0071071)	2.39353177
89	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.38928256
90	positive regulation of muscle hypertrophy (GO:0014742)	2.38928256
91	replication fork processing (GO:0031297)	2.38812677
92	indolalkylamine metabolic process (GO:0006586)	2.38391079
93	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.38020801
94	regulation of DNA endoreduplication (GO:0032875)	2.37335414
95	monoubiquitinated protein deubiquitination (GO:0035520)	2.37236603
96	negative regulation of Rho protein signal transduction (GO:0035024)	2.36892318
97	negative regulation of protein localization to cell surface (GO:2000009)	2.35995984
98	detection of molecule of bacterial origin (GO:0032490)	2.34828411
99	neuronal action potential (GO:0019228)	2.34762197
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.34414512

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.29408073
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.25837089
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.23524241
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.07718260
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.67480847
6	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.33687527
7	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.22748213
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22189913
9	FUS_26573619_Chip-Seq_HEK293_Human	2.00493476
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	12.1818562
11	TP53_16413492_ChIP-PET_HCT116_Human	1.99102613
12	AR_21572438_ChIP-Seq_LNCaP_Human	1.98016740
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.96378246
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84152109
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81136044
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.79899925
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74634185
18	EWS_26573619_Chip-Seq_HEK293_Human	1.74453891
19	GATA1_22025678_ChIP-Seq_K562_Human	1.74429594
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.69349401
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.68388607
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66523735
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62057035
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.61787136
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46860633
26	VDR_22108803_ChIP-Seq_LS180_Human	1.44895049
27	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.44659392
28	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41137640
29	P300_19829295_ChIP-Seq_ESCs_Human	1.39618608
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.37715826
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35335204
32	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.34303642
33	STAT3_23295773_ChIP-Seq_U87_Human	1.33592657
34	AHR_22903824_ChIP-Seq_MCF-7_Human	1.33375660
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33163541
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30404452
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.29287943
38	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.28994300
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26809173
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.26586930
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.26017893
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25087495
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25006777
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.24523839
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24523839
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19252320
47	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16811174
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16630016
49	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.16490872
50	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.11547105
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11090794
52	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.07665599
53	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.06932942
54	RXR_22108803_ChIP-Seq_LS180_Human	1.05856155
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.05596866
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.04915998
57	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.03516816
58	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.02893681
59	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02488143
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01285909
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00662881
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00342863
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99662283
64	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.98904035
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98141144
66	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96439311
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95393113
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.94659180
69	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93866745
70	TCF4_23295773_ChIP-Seq_U87_Human	0.92790121
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92255220
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91858676
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91432447
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.89111718
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.88761251
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.86994708
77	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.86865824
78	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.83779090
79	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.83108403
80	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.81711849
81	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.81533560
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.81308901
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.81141952
84	AR_25329375_ChIP-Seq_VCAP_Human	0.79826703
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.79739335
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.78995543
87	TP53_18474530_ChIP-ChIP_U2OS_Human	0.78985294
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.78918578
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.78254154
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.78165654
91	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.78037929
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.77551857
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77551857
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.77436678
95	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.76308420
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.76081981
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.75629761
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.75428171
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.74607183
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.74607183

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.41063161
2	MP0003183_abnormal_peptide_metabolism	3.92836085
3	MP0002163_abnormal_gland_morphology	3.62969593
4	MP0002735_abnormal_chemical_nociception	3.25931070
5	MP0005171_absent_coat_pigmentation	2.87986913
6	MP0002160_abnormal_reproductive_system	2.76624227
7	MP0005379_endocrine/exocrine_gland_phen	2.49499557
8	MP0002138_abnormal_hepatobiliary_system	2.16052667
9	MP0002089_abnormal_postnatal_growth/wei	2.09766075
10	MP0002332_abnormal_exercise_endurance	2.08493589
11	MP0004134_abnormal_chest_morphology	1.95930703
12	MP0005083_abnormal_biliary_tract	1.91795028
13	MP0005389_reproductive_system_phenotype	1.86389059
14	MP0000383_abnormal_hair_follicle	1.82709614
15	MP0005551_abnormal_eye_electrophysiolog	1.77647633
16	MP0005174_abnormal_tail_pigmentation	1.77418724
17	MP0000613_abnormal_salivary_gland	1.71070485
18	MP0001502_abnormal_circadian_rhythm	1.66745682
19	MP0001485_abnormal_pinna_reflex	1.62815007
20	MP0004215_abnormal_myocardial_fiber	1.61567852
21	MP0000371_diluted_coat_color	1.54079132
22	MP0005253_abnormal_eye_physiology	1.52482720
23	MP0000049_abnormal_middle_ear	1.51768360
24	MP0005423_abnormal_somatic_nervous	1.49175722
25	MP0001968_abnormal_touch/_nociception	1.49067876
26	MP0004885_abnormal_endolymph	1.48118922
27	MP0000631_abnormal_neuroendocrine_gland	1.47592043
28	MP0003890_abnormal_embryonic-extraembry	1.46017988
29	MP0003252_abnormal_bile_duct	1.45351911
30	MP0009250_abnormal_appendicular_skeleto	1.44890036
31	MP0001986_abnormal_taste_sensitivity	1.39707393
32	MP0003950_abnormal_plasma_membrane	1.38841798
33	MP0002736_abnormal_nociception_after	1.38796929
34	MP0008057_abnormal_DNA_replication	1.38686066
35	MP0006072_abnormal_retinal_apoptosis	1.38598069
36	MP0003693_abnormal_embryo_hatching	1.34660880
37	MP0003959_abnormal_lean_body	1.30138260
38	MP0002272_abnormal_nervous_system	1.28349936
39	MP0002928_abnormal_bile_duct	1.27647845
40	MP0004130_abnormal_muscle_cell	1.24245985
41	MP0004264_abnormal_extraembryonic_tissu	1.24152322
42	MP0002638_abnormal_pupillary_reflex	1.23582550
43	MP0005646_abnormal_pituitary_gland	1.20678763
44	MP0003937_abnormal_limbs/digits/tail_de	1.20286047
45	MP0002938_white_spotting	1.17201635
46	MP0004147_increased_porphyrin_level	1.09083345
47	MP0009379_abnormal_foot_pigmentation	1.08712538
48	MP0000427_abnormal_hair_cycle	1.08643200
49	MP0005220_abnormal_exocrine_pancreas	1.08498760
50	MP0001440_abnormal_grooming_behavior	1.04976292
51	MP0010386_abnormal_urinary_bladder	1.04901334
52	MP0000733_abnormal_muscle_development	1.04539957
53	MP0001879_abnormal_lymphatic_vessel	1.04106531
54	MP0004142_abnormal_muscle_tone	1.03883240
55	MP0008872_abnormal_physiological_respon	1.03054474
56	MP0002108_abnormal_muscle_morphology	1.02621275
57	MP0006276_abnormal_autonomic_nervous	1.01490030
58	MP0000372_irregular_coat_pigmentation	0.98957431
59	MP0002282_abnormal_trachea_morphology	0.96863507
60	MP0002733_abnormal_thermal_nociception	0.95804239
61	MP0003195_calcinosis	0.95788032
62	MP0002254_reproductive_system_inflammat	0.93388378
63	MP0004742_abnormal_vestibular_system	0.91934441
64	MP0001970_abnormal_pain_threshold	0.91158010
65	MP0005167_abnormal_blood-brain_barrier	0.89546938
66	MP0009046_muscle_twitch	0.89219440
67	MP0000026_abnormal_inner_ear	0.88246688
68	MP0000163_abnormal_cartilage_morphology	0.87702100
69	MP0000750_abnormal_muscle_regeneration	0.87518464
70	MP0003936_abnormal_reproductive_system	0.85615447
71	MP0001145_abnormal_male_reproductive	0.85313906
72	MP0010678_abnormal_skin_adnexa	0.84881312
73	MP0002971_abnormal_brown_adipose	0.83820882
74	MP0009384_cardiac_valve_regurgitation	0.83300052
75	MP0002095_abnormal_skin_pigmentation	0.82738115
76	MP0000428_abnormal_craniofacial_morphol	0.82276588
77	MP0006292_abnormal_olfactory_placode	0.82152608
78	MP0005386_behavior/neurological_phenoty	0.81005513
79	MP0004924_abnormal_behavior	0.81005513
80	MP0002127_abnormal_cardiovascular_syste	0.80530344
81	MP0000653_abnormal_sex_gland	0.79780595
82	MP0002822_catalepsy	0.79274035
83	MP0001905_abnormal_dopamine_level	0.78137382
84	MP0005647_abnormal_sex_gland	0.77726433
85	MP0002075_abnormal_coat/hair_pigmentati	0.77710376
86	MP0005266_abnormal_metabolism	0.77335230
87	MP0002116_abnormal_craniofacial_bone	0.71184120
88	MP0005503_abnormal_tendon_morphology	0.70586237
89	MP0002067_abnormal_sensory_capabilities	0.70240077
90	MP0000579_abnormal_nail_morphology	0.68725796
91	MP0000762_abnormal_tongue_morphology	0.68508034
92	MP0003136_yellow_coat_color	0.66427426
93	MP0002210_abnormal_sex_determination	0.64970862
94	MP0009115_abnormal_fat_cell	0.64620214
95	MP0002111_abnormal_tail_morphology	0.64530732
96	MP0001666_abnormal_nutrient_absorption	0.64112180
97	MP0001486_abnormal_startle_reflex	0.63746139
98	MP0002109_abnormal_limb_morphology	0.63229944
99	MP0003935_abnormal_craniofacial_develop	0.62350036
100	MP0000230_abnormal_systemic_arterial	0.62313434

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Anomalous pulmonary venous return (HP:0010772)	4.75788353
2	Deformed sella turcica (HP:0002681)	4.75512504
3	Oral leukoplakia (HP:0002745)	4.69932007
4	Short 4th metacarpal (HP:0010044)	4.65559771
5	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	4.65559771
6	Neoplasm of the heart (HP:0100544)	4.21005269
7	Abnormality of the parietal bone (HP:0002696)	4.15494601
8	Abnormality of the pulmonary veins (HP:0011718)	4.15115428
9	Short phalanx of the thumb (HP:0009660)	3.96173876
10	Abnormality of the sella turcica (HP:0002679)	3.88620076
11	Genetic anticipation (HP:0003743)	3.65589136
12	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	3.57155440
13	Diastasis recti (HP:0001540)	3.44322059
14	Carpal bone hypoplasia (HP:0001498)	3.35321449
15	Pancreatic fibrosis (HP:0100732)	3.34446302
16	Abnormality of the 4th metacarpal (HP:0010012)	3.32349693
17	True hermaphroditism (HP:0010459)	3.24696701
18	Pancreatic cysts (HP:0001737)	3.19718662
19	Vertebral fusion (HP:0002948)	3.11270119
20	Aortic regurgitation (HP:0001659)	3.02887555
21	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.96518791
22	Concave nail (HP:0001598)	2.95060870
23	Down-sloping shoulders (HP:0200021)	2.90362020
24	Vertebral arch anomaly (HP:0008438)	2.88391498
25	Chronic hepatic failure (HP:0100626)	2.86900129
26	Medulloblastoma (HP:0002885)	2.80203338
27	Abnormality of the odontoid process (HP:0003310)	2.78819111
28	Congenital, generalized hypertrichosis (HP:0004540)	2.71580567
29	Supernumerary bones of the axial skeleton (HP:0009144)	2.71142567
30	Supernumerary ribs (HP:0005815)	2.68932747
31	Broad ribs (HP:0000885)	2.54084090
32	J-shaped sella turcica (HP:0002680)	2.50578518
33	Hemivertebrae (HP:0002937)	2.48786316
34	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.47938217
35	Hypoplasia of the pons (HP:0012110)	2.46708072
36	Neoplasm of the oral cavity (HP:0100649)	2.44477877
37	Abnormal number of erythroid precursors (HP:0012131)	2.40138266
38	Abnormality of the pons (HP:0007361)	2.31184000
39	Furrowed tongue (HP:0000221)	2.28862985
40	Abnormality of the renal collecting system (HP:0004742)	2.28312690
41	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.27550439
42	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.25857680
43	Skin pits (HP:0100276)	2.25687847
44	Tongue fasciculations (HP:0001308)	2.22970792
45	Fibular aplasia (HP:0002990)	2.21709264
46	Cystic liver disease (HP:0006706)	2.19618844
47	Hemiplegia (HP:0002301)	2.17405866
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15769322
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15702610
50	Thoracolumbar scoliosis (HP:0002944)	2.14442826
51	Impaired smooth pursuit (HP:0007772)	2.12472055
52	Nephronophthisis (HP:0000090)	2.11304455
53	Progressive cerebellar ataxia (HP:0002073)	2.09988120
54	Slow saccadic eye movements (HP:0000514)	2.09670723
55	Action tremor (HP:0002345)	2.08054825
56	Hamartoma (HP:0010566)	2.08030188
57	Hepatocellular necrosis (HP:0001404)	2.07574982
58	Neoplasm of striated muscle (HP:0009728)	2.06508406
59	Milia (HP:0001056)	2.03990310
60	Coronal craniosynostosis (HP:0004440)	1.98330482
61	Ectopic kidney (HP:0000086)	1.97601579
62	Duplicated collecting system (HP:0000081)	1.95293457
63	Tubular atrophy (HP:0000092)	1.94882357
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94222966
65	Premature graying of hair (HP:0002216)	1.94024987
66	Small hand (HP:0200055)	1.90335500
67	Short thumb (HP:0009778)	1.90121751
68	Clumsiness (HP:0002312)	1.89141819
69	Abnormality of the renal cortex (HP:0011035)	1.88589978
70	Pendular nystagmus (HP:0012043)	1.87252650
71	Ulnar claw (HP:0001178)	1.85613528
72	Abnormality of chromosome stability (HP:0003220)	1.84997799
73	Urethral obstruction (HP:0000796)	1.84694241
74	Flared iliac wings (HP:0002869)	1.83989117
75	Abnormality of cells of the erythroid lineage (HP:0012130)	1.81964546
76	Recurrent bronchitis (HP:0002837)	1.80163399
77	Broad alveolar ridges (HP:0000187)	1.77286461
78	Muscle fibrillation (HP:0010546)	1.76865273
79	Sloping forehead (HP:0000340)	1.76480475
80	Anencephaly (HP:0002323)	1.76370283
81	Hypoplastic iliac wings (HP:0002866)	1.73535047
82	Wide intermamillary distance (HP:0006610)	1.72710510
83	Abnormality of DNA repair (HP:0003254)	1.72406973
84	Short tibia (HP:0005736)	1.71366161
85	Molar tooth sign on MRI (HP:0002419)	1.71331846
86	Abnormality of midbrain morphology (HP:0002418)	1.71331846
87	Abnormality of the renal medulla (HP:0100957)	1.70928692
88	Abnormality of the lumbar spine (HP:0100712)	1.69110816
89	Beaking of vertebral bodies (HP:0004568)	1.67472287
90	Hamartoma of the eye (HP:0010568)	1.66833253
91	Congenital hepatic fibrosis (HP:0002612)	1.66682970
92	Abnormality of the wing of the ilium (HP:0011867)	1.65830020
93	Clubbing of toes (HP:0100760)	1.65317119
94	Abnormality of ocular smooth pursuit (HP:0000617)	1.64919632
95	Sparse lateral eyebrow (HP:0005338)	1.64702740
96	Abnormality of the preputium (HP:0100587)	1.64430750
97	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.64365611
98	Duplication of thumb phalanx (HP:0009942)	1.61429885
99	Abolished electroretinogram (ERG) (HP:0000550)	1.61368375
100	Gaze-evoked nystagmus (HP:0000640)	1.59615341

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	6.79853498
2	ZAK	5.27974798
3	BLK	4.78082910
4	FRK	3.75304565
5	ACVR1B	2.80742260
6	VRK1	2.36536740
7	SGK2	2.22502137
8	BMPR1B	2.12665402
9	CDK12	2.02879562
10	GRK1	1.97195936
11	INSRR	1.92927326
12	MAP2K4	1.64183588
13	SGK223	1.59858179
14	SGK494	1.59858179
15	GRK7	1.57036428
16	FGFR2	1.55418298
17	ADRBK2	1.48055773
18	MAP3K4	1.45212688
19	AKT3	1.40606093
20	SGK3	1.37944493
21	RPS6KA5	1.35144655
22	CAMK4	1.26449869
23	MAP2K3	1.24472702
24	MAP2K7	1.23156909
25	TNIK	1.21339636
26	CAMK1D	1.16930004
27	BRSK2	1.05932700
28	STK4	1.05634530
29	PHKG1	1.05402946
30	PHKG2	1.05402946
31	BRD4	1.02845965
32	MELK	1.00812793
33	TAOK3	0.98679598
34	STK38L	0.96737004
35	PIM1	0.95906165
36	OBSCN	0.94643076
37	ADRBK1	0.94065219
38	CAMKK2	0.85468045
39	CAMK1G	0.83263375
40	RPS6KA6	0.81274473
41	NEK9	0.81095822
42	DYRK3	0.80084267
43	PINK1	0.78640971
44	ERBB2	0.77378035
45	TIE1	0.75573981
46	STK16	0.75357396
47	FGFR1	0.71398607
48	MAPK15	0.70231463
49	SGK1	0.69337725
50	MAP3K2	0.67876395
51	PKN1	0.67614646
52	EPHA3	0.66087705
53	LATS1	0.64082397
54	NLK	0.63763229
55	CASK	0.62417944
56	PRKAA1	0.61776497
57	DAPK3	0.58896213
58	HIPK2	0.58773002
59	MAPK7	0.58302870
60	TGFBR2	0.57139375
61	MAP3K6	0.56755151
62	PTK2B	0.56214597
63	MAP2K6	0.55572217
64	RPS6KC1	0.54992841
65	RPS6KL1	0.54992841
66	AURKA	0.52031645
67	GRK5	0.51850186
68	RET	0.46731424
69	SYK	0.43909582
70	PDGFRB	0.43408374
71	MAP3K7	0.43367548
72	NTRK3	0.43053635
73	NEK6	0.42778939
74	WNK1	0.40493553
75	AURKB	0.40020347
76	MUSK	0.39910077
77	CAMK2B	0.38838879
78	MET	0.38571746
79	STK3	0.37229631
80	IKBKB	0.34006333
81	MAPK13	0.33705930
82	DAPK2	0.33466766
83	TEC	0.31527277
84	MST4	0.31435626
85	MAP2K1	0.30815046
86	WNK3	0.30220533
87	TAF1	0.30175362
88	MAP4K2	0.29522293
89	CHUK	0.28208014
90	CSNK1G1	0.28003703
91	CAMK2G	0.27412314
92	PRKAA2	0.26776936
93	IRAK1	0.26619947
94	WNK4	0.26085114
95	CSNK1A1L	0.25983345
96	EPHA2	0.25692860
97	STK11	0.25326304
98	TXK	0.24680236
99	ROCK1	0.24587621
100	CDK9	0.24535797

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	6.70667050
2	Alcoholism_Homo sapiens_hsa05034	4.49582265
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.05243882
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03799419
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00079993
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97272501
7	Ribosome_Homo sapiens_hsa03010	1.94198467
8	Viral carcinogenesis_Homo sapiens_hsa05203	1.70866695
9	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.64017632
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.63521311
11	Pancreatic secretion_Homo sapiens_hsa04972	1.62053284
12	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.61007511
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.54823678
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52261840
15	Basal cell carcinoma_Homo sapiens_hsa05217	1.49478936
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.49333395
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46929782
18	Nicotine addiction_Homo sapiens_hsa05033	1.40710751
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.39173089
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.38948075
21	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.37546646
22	Taste transduction_Homo sapiens_hsa04742	1.36878589
23	Bile secretion_Homo sapiens_hsa04976	1.29763647
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26813452
25	ABC transporters_Homo sapiens_hsa02010	1.24993411
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.13585964
27	Morphine addiction_Homo sapiens_hsa05032	1.12956791
28	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.11187074
29	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.10932750
30	Salivary secretion_Homo sapiens_hsa04970	1.10052453
31	Homologous recombination_Homo sapiens_hsa03440	1.09850100
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09095202
33	Insulin secretion_Homo sapiens_hsa04911	1.07618878
34	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.04905139
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.02492928
36	Circadian rhythm_Homo sapiens_hsa04710	1.01410070
37	Calcium signaling pathway_Homo sapiens_hsa04020	1.00767158
38	Glutamatergic synapse_Homo sapiens_hsa04724	0.98944215
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96577386
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96259004
41	Renin secretion_Homo sapiens_hsa04924	0.95709845
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.95331973
43	Gastric acid secretion_Homo sapiens_hsa04971	0.93650919
44	GABAergic synapse_Homo sapiens_hsa04727	0.91029570
45	Huntingtons disease_Homo sapiens_hsa05016	0.89891215
46	Histidine metabolism_Homo sapiens_hsa00340	0.89394069
47	Caffeine metabolism_Homo sapiens_hsa00232	0.88862303
48	Alzheimers disease_Homo sapiens_hsa05010	0.87905979
49	Cholinergic synapse_Homo sapiens_hsa04725	0.86835793
50	Parkinsons disease_Homo sapiens_hsa05012	0.86020634
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.81168397
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80650531
53	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.79098894
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.77189213
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75561462
56	Circadian entrainment_Homo sapiens_hsa04713	0.74166399
57	Protein digestion and absorption_Homo sapiens_hsa04974	0.71633622
58	One carbon pool by folate_Homo sapiens_hsa00670	0.71446818
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.70477527
60	Basal transcription factors_Homo sapiens_hsa03022	0.69986226
61	RNA polymerase_Homo sapiens_hsa03020	0.69369366
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.66618166
63	Regulation of autophagy_Homo sapiens_hsa04140	0.64135035
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64053117
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.62499806
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60819038
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60648966
68	Gap junction_Homo sapiens_hsa04540	0.58334035
69	Phototransduction_Homo sapiens_hsa04744	0.57495919
70	Melanoma_Homo sapiens_hsa05218	0.57073609
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56753248
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56305947
73	Mineral absorption_Homo sapiens_hsa04978	0.55357137
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.53193450
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52949546
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52489330
77	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.52239692
78	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50713030
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.49972733
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47759889
81	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47664406
82	Renin-angiotensin system_Homo sapiens_hsa04614	0.47015384
83	GnRH signaling pathway_Homo sapiens_hsa04912	0.46783299
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.46583879
85	Amphetamine addiction_Homo sapiens_hsa05031	0.45811285
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.45039715
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44443620
88	Melanogenesis_Homo sapiens_hsa04916	0.44049056
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.42833452
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.42723370
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41392753
92	Serotonergic synapse_Homo sapiens_hsa04726	0.41026210
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40534804
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38303894
95	Olfactory transduction_Homo sapiens_hsa04740	0.38138812
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.36982069
97	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.35547275
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.33323351
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33237104
100	Peroxisome_Homo sapiens_hsa04146	0.31089076

METTL12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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