METTL13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.84704029
2nuclear pore complex assembly (GO:0051292)4.70009447
3folic acid-containing compound biosynthetic process (GO:0009396)4.47546549
4DNA unwinding involved in DNA replication (GO:0006268)4.42623678
5IMP biosynthetic process (GO:0006188)4.35575078
6nucleobase biosynthetic process (GO:0046112)4.34115291
7establishment of integrated proviral latency (GO:0075713)4.31565041
8DNA replication initiation (GO:0006270)4.28599362
9protein localization to kinetochore (GO:0034501)4.26880542
10regulation of translational fidelity (GO:0006450)4.18595717
11mitotic nuclear envelope disassembly (GO:0007077)4.17595930
12DNA replication checkpoint (GO:0000076)4.04794973
13mitotic chromosome condensation (GO:0007076)4.01479504
14formation of translation preinitiation complex (GO:0001731)4.00889869
15DNA strand elongation involved in DNA replication (GO:0006271)4.00430794
16purine nucleobase biosynthetic process (GO:0009113)3.95437045
17ribosome biogenesis (GO:0042254)3.95356011
18maturation of SSU-rRNA (GO:0030490)3.88192468
19ribosome assembly (GO:0042255)3.85764437
20membrane disassembly (GO:0030397)3.81265524
21nuclear envelope disassembly (GO:0051081)3.81265524
22DNA strand elongation (GO:0022616)3.80943279
23protein complex localization (GO:0031503)3.75811882
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.72896696
25telomere maintenance via semi-conservative replication (GO:0032201)3.70591964
26ribosomal large subunit biogenesis (GO:0042273)3.70013149
27iron ion import (GO:0097286)3.68731541
28COPI coating of Golgi vesicle (GO:0048205)3.65832878
29Golgi transport vesicle coating (GO:0048200)3.65832878
30DNA replication-dependent nucleosome assembly (GO:0006335)3.64482244
31DNA replication-dependent nucleosome organization (GO:0034723)3.64482244
32mitotic metaphase plate congression (GO:0007080)3.63544648
33IMP metabolic process (GO:0046040)3.61162072
34pore complex assembly (GO:0046931)3.61035339
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.60338511
36cellular protein complex localization (GO:0034629)3.57783078
37DNA duplex unwinding (GO:0032508)3.52576513
38ribonucleoprotein complex biogenesis (GO:0022613)3.52007095
39DNA geometric change (GO:0032392)3.50665529
40proline biosynthetic process (GO:0006561)3.48234442
41pentose-phosphate shunt (GO:0006098)3.47516069
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47041414
43protein localization to chromosome, centromeric region (GO:0071459)3.42534035
44pseudouridine synthesis (GO:0001522)3.41498120
45NADPH regeneration (GO:0006740)3.37312361
46rRNA processing (GO:0006364)3.32923048
47nucleobase-containing small molecule interconversion (GO:0015949)3.32441111
48proteasome assembly (GO:0043248)3.32258172
49regulation of spindle organization (GO:0090224)3.30925403
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30097809
51negative regulation of ligase activity (GO:0051352)3.30097809
52establishment of viral latency (GO:0019043)3.29329829
53mitotic sister chromatid segregation (GO:0000070)3.28655940
54telomere maintenance via recombination (GO:0000722)3.28157228
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27639426
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27076761
57ribosomal small subunit assembly (GO:0000028)3.26693097
58negative regulation of mRNA processing (GO:0050686)3.25200778
59mitotic recombination (GO:0006312)3.24253579
60negative regulation of RNA splicing (GO:0033119)3.24221035
61rRNA metabolic process (GO:0016072)3.23713175
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21483523
63folic acid metabolic process (GO:0046655)3.20364789
64telomere maintenance via telomere lengthening (GO:0010833)3.18740215
65chromatin remodeling at centromere (GO:0031055)3.15758039
66CENP-A containing nucleosome assembly (GO:0034080)3.15680008
67metaphase plate congression (GO:0051310)3.14266787
68tRNA aminoacylation for protein translation (GO:0006418)3.12958260
69spliceosomal snRNP assembly (GO:0000387)3.12857501
70tRNA methylation (GO:0030488)3.09987697
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09547365
72kinetochore organization (GO:0051383)3.08696451
73sister chromatid segregation (GO:0000819)3.08636051
74DNA replication-independent nucleosome organization (GO:0034724)3.07346036
75DNA replication-independent nucleosome assembly (GO:0006336)3.07346036
76tRNA aminoacylation (GO:0043039)3.05614132
77amino acid activation (GO:0043038)3.05614132
78maturation of 5.8S rRNA (GO:0000460)3.05549909
79tetrahydrofolate metabolic process (GO:0046653)3.02932919
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02341120
81rRNA modification (GO:0000154)3.01095201
82regulation of mitotic spindle organization (GO:0060236)3.00661336
83spindle assembly checkpoint (GO:0071173)3.00654527
84protein maturation by protein folding (GO:0022417)2.98493287
85negative regulation of chromosome segregation (GO:0051985)2.97405990
86mitotic spindle assembly checkpoint (GO:0007094)2.97219901
87RNA splicing, via transesterification reactions (GO:0000375)2.94995459
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94451654
89negative regulation of sister chromatid segregation (GO:0033046)2.94451654
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.94451654
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94451654
92kinetochore assembly (GO:0051382)2.94392092
93RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94197806
94mRNA splicing, via spliceosome (GO:0000398)2.94197806
95DNA deamination (GO:0045006)2.94183665
96spindle checkpoint (GO:0031577)2.91994377
97chromatin assembly or disassembly (GO:0006333)2.90956699
98dosage compensation (GO:0007549)2.90385270
99peptidyl-arginine omega-N-methylation (GO:0035247)2.89819761
100ribosomal small subunit biogenesis (GO:0042274)2.89001526
101mitotic spindle checkpoint (GO:0071174)2.87497596
102rRNA transcription (GO:0009303)2.87405801
103nuclear envelope organization (GO:0006998)2.86797502
104protein K6-linked ubiquitination (GO:0085020)2.85662058
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85079200
106negative regulation of mRNA metabolic process (GO:1903312)2.84531568
107termination of RNA polymerase II transcription (GO:0006369)2.83747887
108spliceosomal complex assembly (GO:0000245)2.83593769
109mRNA transport (GO:0051028)2.83248900
110spliceosomal tri-snRNP complex assembly (GO:0000244)2.82774649
111L-serine metabolic process (GO:0006563)2.82645715
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82235978
113RNA export from nucleus (GO:0006405)2.81155453
114regulation of cellular amino acid metabolic process (GO:0006521)2.80263020
115pteridine-containing compound biosynthetic process (GO:0042559)2.79930746
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79395402
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.79395402
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79315258
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.79315258
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78975222
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78975222
122meiotic chromosome segregation (GO:0045132)2.78315991
123translesion synthesis (GO:0019985)2.77749474
124folic acid-containing compound metabolic process (GO:0006760)2.77728593
125mRNA export from nucleus (GO:0006406)2.77001040
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76482850
127DNA conformation change (GO:0071103)2.75690533
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75488137
129signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75488137
130signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75488137
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74904130
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74203071
133regulation of chromosome segregation (GO:0051983)2.74015872
134heme biosynthetic process (GO:0006783)2.73853104
135translational initiation (GO:0006413)2.73639280
136regulation of ubiquitin-protein transferase activity (GO:0051438)2.73227920
137regulation of translational termination (GO:0006449)2.73193513
138pre-miRNA processing (GO:0031054)2.73173605
139establishment of chromosome localization (GO:0051303)2.72911942
140translational termination (GO:0006415)2.72773415
141heterochromatin organization (GO:0070828)2.72382737
142regulation of translational elongation (GO:0006448)2.71480060
143ncRNA processing (GO:0034470)2.71327593
144tricarboxylic acid cycle (GO:0006099)2.70589466
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.69474685
146protein export from nucleus (GO:0006611)2.69252789
147cell cycle G1/S phase transition (GO:0044843)2.68325750
148G1/S transition of mitotic cell cycle (GO:0000082)2.68325750
149glucose catabolic process (GO:0006007)2.66696725
150mitochondrial DNA metabolic process (GO:0032042)2.64302516
151regulation of transcription from RNA polymerase I promoter (GO:0006356)2.64267022
152tricarboxylic acid metabolic process (GO:0072350)2.63765533
153regulation of ligase activity (GO:0051340)2.62745044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.29378534
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36800685
3* FOXM1_23109430_ChIP-Seq_U2OS_Human4.07933667
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86513262
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46172113
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17770814
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04520898
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87759667
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78409808
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69571039
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.55462833
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49199615
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.43579144
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.35493083
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35377135
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33153181
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.29966744
18MYC_22102868_ChIP-Seq_BL_Human2.25237988
19* XRN2_22483619_ChIP-Seq_HELA_Human2.22010491
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.13958324
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10809905
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03047019
23* VDR_23849224_ChIP-Seq_CD4+_Human2.00987353
24AR_21909140_ChIP-Seq_LNCAP_Human1.96540934
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95066104
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93997189
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.93498926
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93210635
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93163023
30FOXP3_21729870_ChIP-Seq_TREG_Human1.92217157
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80422763
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79601287
33GABP_19822575_ChIP-Seq_HepG2_Human1.78029858
34CIITA_25753668_ChIP-Seq_RAJI_Human1.76785643
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76403092
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72610800
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71901001
38DCP1A_22483619_ChIP-Seq_HELA_Human1.71458412
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69466354
40* TTF2_22483619_ChIP-Seq_HELA_Human1.68206533
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66559887
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65384639
43ZNF263_19887448_ChIP-Seq_K562_Human1.64105317
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61797439
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60880378
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.55903603
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55490919
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53478153
49ELK1_19687146_ChIP-ChIP_HELA_Human1.48654282
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47676833
51KDM5A_27292631_Chip-Seq_BREAST_Human1.46907546
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44317223
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44316730
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39477667
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39380457
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.38769604
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38632894
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38236883
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35528069
60VDR_21846776_ChIP-Seq_THP-1_Human1.34464371
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32963561
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29601570
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26205350
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25655355
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24824451
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24207893
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23892323
68* TFEB_21752829_ChIP-Seq_HELA_Human1.23338840
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22275770
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19677408
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17676667
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17636372
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17553655
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16803666
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.16799397
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13618663
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.13081706
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12331552
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08767415
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.08124076
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07191537
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05925553
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05925553
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05925553
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03477554
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03237246
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03075943
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02650189
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01364280
90MYC_18940864_ChIP-ChIP_HL60_Human1.01207992
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01088198
92RACK7_27058665_Chip-Seq_MCF-7_Human1.00900770
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99980350
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99648052
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98707784
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98084314
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97809480
98* CHD1_26751641_Chip-Seq_LNCaP_Human0.97091835
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96332960
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96066827
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94909937
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91893525
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91511964
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90174429
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90058853
106ATF3_27146783_Chip-Seq_COLON_Human0.90013376
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89350897
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87625991
109CLOCK_20551151_ChIP-Seq_293T_Human0.87413692
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87031340
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86720427
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85911224
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83333661
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82025934
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.81125185
116SPI1_23547873_ChIP-Seq_NB4_Human0.81058537
117* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81047939
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.79070700
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77478792
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77301825
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75855428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.83541466
2MP0003111_abnormal_nucleus_morphology4.19721305
3MP0010094_abnormal_chromosome_stability4.05283238
4MP0008057_abnormal_DNA_replication3.82771501
5MP0004147_increased_porphyrin_level3.64562999
6MP0004957_abnormal_blastocyst_morpholog3.59799693
7MP0003077_abnormal_cell_cycle3.48549430
8MP0008058_abnormal_DNA_repair2.97100745
9MP0002396_abnormal_hematopoietic_system2.82856265
10MP0008007_abnormal_cellular_replicative2.54210976
11MP0002877_abnormal_melanocyte_morpholog2.37423378
12MP0008932_abnormal_embryonic_tissue2.32516610
13MP0010352_gastrointestinal_tract_polyps2.27865721
14MP0000350_abnormal_cell_proliferation2.15797306
15MP0003656_abnormal_erythrocyte_physiolo2.06546192
16MP0003890_abnormal_embryonic-extraembry2.04140162
17MP0004233_abnormal_muscle_weight2.00424606
18MP0002254_reproductive_system_inflammat1.97708300
19MP0001730_embryonic_growth_arrest1.96285232
20MP0003123_paternal_imprinting1.83788102
21MP0000490_abnormal_crypts_of1.81696482
22MP0005451_abnormal_body_composition1.80154635
23MP0005380_embryogenesis_phenotype1.79022179
24MP0001672_abnormal_embryogenesis/_devel1.79022179
25MP0008260_abnormal_autophagy1.76727803
26MP0002796_impaired_skin_barrier1.73967688
27MP0003786_premature_aging1.73369341
28MP0010307_abnormal_tumor_latency1.58609395
29MP0005076_abnormal_cell_differentiation1.58452060
30MP0003984_embryonic_growth_retardation1.57623469
31MP0010030_abnormal_orbit_morphology1.55925634
32MP0001697_abnormal_embryo_size1.54479412
33MP0002088_abnormal_embryonic_growth/wei1.54457598
34MP0005058_abnormal_lysosome_morphology1.51204612
35MP0009053_abnormal_anal_canal1.50707268
36MP0005501_abnormal_skin_physiology1.49531262
37MP0004808_abnormal_hematopoietic_stem1.49365078
38MP0001873_stomach_inflammation1.48258987
39MP0002085_abnormal_embryonic_tissue1.45370655
40MP0002080_prenatal_lethality1.44743562
41MP0003763_abnormal_thymus_physiology1.44675779
42MP0004197_abnormal_fetal_growth/weight/1.44396574
43MP0009333_abnormal_splenocyte_physiolog1.40500730
44MP0002132_abnormal_respiratory_system1.39357278
45MP0002086_abnormal_extraembryonic_tissu1.39284758
46MP0002084_abnormal_developmental_patter1.39161712
47MP0006292_abnormal_olfactory_placode1.34282918
48MP0001293_anophthalmia1.33605587
49MP0000313_abnormal_cell_death1.33228421
50MP0003315_abnormal_perineum_morphology1.31714848
51MP0002019_abnormal_tumor_incidence1.27449719
52MP0010234_abnormal_vibrissa_follicle1.23959170
53MP0003186_abnormal_redox_activity1.22832182
54MP0004185_abnormal_adipocyte_glucose1.22611552
55MP0008438_abnormal_cutaneous_collagen1.22563195
56MP0000703_abnormal_thymus_morphology1.22542558
57MP0005075_abnormal_melanosome_morpholog1.20675351
58MP0003119_abnormal_digestive_system1.20592789
59MP0001661_extended_life_span1.18148318
60MP0002060_abnormal_skin_morphology1.17148118
61MP0000627_abnormal_mammary_gland1.16405662
62MP0004782_abnormal_surfactant_physiolog1.14865373
63MP0000428_abnormal_craniofacial_morphol1.11081063
64MP0002398_abnormal_bone_marrow1.09180557
65MP0003718_maternal_effect1.09028552
66MP0003567_abnormal_fetal_cardiomyocyte1.08652983
67MP0001216_abnormal_epidermal_layer1.08624163
68MP0002277_abnormal_respiratory_mucosa1.07887571
69MP0001881_abnormal_mammary_gland1.07802969
70MP0003941_abnormal_skin_development1.07777610
71MP0002111_abnormal_tail_morphology1.04987603
72MP0002722_abnormal_immune_system1.03144531
73MP0003453_abnormal_keratinocyte_physiol1.03055390
74MP0003705_abnormal_hypodermis_morpholog1.02753738
75MP0003121_genomic_imprinting1.01531487
76MP0009840_abnormal_foam_cell1.01146095
77MP0004133_heterotaxia1.00286471
78MP0000689_abnormal_spleen_morphology0.97986076
79MP0003937_abnormal_limbs/digits/tail_de0.96602062
80MP0000371_diluted_coat_color0.95111712
81MP0006036_abnormal_mitochondrial_physio0.94898666
82MP0004264_abnormal_extraembryonic_tissu0.91892105
83MP0001727_abnormal_embryo_implantation0.91736192
84MP0006035_abnormal_mitochondrial_morpho0.90390518
85MP0003806_abnormal_nucleotide_metabolis0.90273579
86MP0005395_other_phenotype0.89067212
87MP0000358_abnormal_cell_content/0.88876074
88MP0009931_abnormal_skin_appearance0.88693517
89MP0005257_abnormal_intraocular_pressure0.88374640
90MP0008877_abnormal_DNA_methylation0.87030880
91MP0000678_abnormal_parathyroid_gland0.86556058
92MP0000432_abnormal_head_morphology0.86196244
93MP0000858_altered_metastatic_potential0.85689789
94MP0001545_abnormal_hematopoietic_system0.85134541
95MP0005397_hematopoietic_system_phenotyp0.85134541
96MP0002092_abnormal_eye_morphology0.84907594
97MP0002210_abnormal_sex_determination0.84672088
98MP0000049_abnormal_middle_ear0.84355537
99MP0000579_abnormal_nail_morphology0.84298450
100MP0003566_abnormal_cell_adhesion0.83751844
101MP0005408_hypopigmentation0.83640458
102MP0009672_abnormal_birth_weight0.83593519
103MP0000537_abnormal_urethra_morphology0.83556258
104MP0002075_abnormal_coat/hair_pigmentati0.83000140
105MP0001853_heart_inflammation0.81861485
106MP0002429_abnormal_blood_cell0.81268930
107MP0002095_abnormal_skin_pigmentation0.81165208
108MP0001348_abnormal_lacrimal_gland0.80911645
109MP0002932_abnormal_joint_morphology0.80772182
110MP0001243_abnormal_dermal_layer0.79410454
111MP0005621_abnormal_cell_physiology0.78467240
112MP0009703_decreased_birth_body0.75897545
113MP0001119_abnormal_female_reproductive0.74732187
114MP0005384_cellular_phenotype0.74320012
115MP0003935_abnormal_craniofacial_develop0.74013607
116MP0003136_yellow_coat_color0.72871383
117MP0003221_abnormal_cardiomyocyte_apopto0.72779975
118MP0001145_abnormal_male_reproductive0.72617699
119MP0000377_abnormal_hair_follicle0.71842596
120MP0001186_pigmentation_phenotype0.71766720
121MP0000716_abnormal_immune_system0.71584853
122MP0005023_abnormal_wound_healing0.71425788
123MP0001849_ear_inflammation0.69596465
124MP0004381_abnormal_hair_follicle0.68980376
125MP0000467_abnormal_esophagus_morphology0.67450601
126MP0004858_abnormal_nervous_system0.66812694
127MP0003115_abnormal_respiratory_system0.66279608
128MP0002114_abnormal_axial_skeleton0.64047508
129MP0003755_abnormal_palate_morphology0.64037996
130MP0002089_abnormal_postnatal_growth/wei0.63669625
131MP0001800_abnormal_humoral_immune0.63463872
132MP0000383_abnormal_hair_follicle0.62668179
133MP0001286_abnormal_eye_development0.62425882
134MP0003942_abnormal_urinary_system0.62317645
135MP0001915_intracranial_hemorrhage0.62210508
136MP0004947_skin_inflammation0.61837870
137MP0003699_abnormal_female_reproductive0.61786716
138MP0009278_abnormal_bone_marrow0.61555761
139MP0002938_white_spotting0.61032812
140MP0009697_abnormal_copulation0.60596563
141MP0000372_irregular_coat_pigmentation0.60369042
142MP0002697_abnormal_eye_size0.60331938
143MP0002098_abnormal_vibrissa_morphology0.59998172
144MP0003936_abnormal_reproductive_system0.59611209
145MP0001346_abnormal_lacrimal_gland0.59092715

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)4.30626028
2Centrally nucleated skeletal muscle fibers (HP:0003687)4.21201796
3Cholecystitis (HP:0001082)4.07288872
4Abnormal gallbladder physiology (HP:0012438)4.07288872
5Chromsome breakage (HP:0040012)3.79886883
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78987910
7Shoulder girdle muscle weakness (HP:0003547)3.54088032
8Increased connective tissue (HP:0009025)3.52399513
9Birth length less than 3rd percentile (HP:0003561)3.33553580
10Pelvic girdle muscle weakness (HP:0003749)3.24730333
11Medulloblastoma (HP:0002885)3.18887342
12Reticulocytopenia (HP:0001896)3.13985782
13Increased hepatocellular lipid droplets (HP:0006565)3.05039443
14Ependymoma (HP:0002888)3.04881644
15Progressive external ophthalmoplegia (HP:0000590)2.98765818
16Multiple enchondromatosis (HP:0005701)2.85806778
17Meckel diverticulum (HP:0002245)2.84946958
18Colon cancer (HP:0003003)2.74738874
19Abnormality of the ileum (HP:0001549)2.74555629
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.72608795
21Lipid accumulation in hepatocytes (HP:0006561)2.69751602
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66902064
23Ileus (HP:0002595)2.63929223
24Prominent nose (HP:0000448)2.63666285
25Abnormality of the hip-girdle musculature (HP:0001445)2.62052665
26Abnormality of the musculature of the pelvis (HP:0001469)2.62052665
27Premature rupture of membranes (HP:0001788)2.54413880
28Abnormality of cells of the erythroid lineage (HP:0012130)2.51509775
29Abnormal number of erythroid precursors (HP:0012131)2.50199267
30Abnormality of chromosome stability (HP:0003220)2.49832025
31Rough bone trabeculation (HP:0100670)2.49815454
32Patellar aplasia (HP:0006443)2.47951620
33Impulsivity (HP:0100710)2.47666521
34Rhabdomyosarcoma (HP:0002859)2.45899841
35Abnormality of the preputium (HP:0100587)2.45267501
36Osteolytic defects of the hand bones (HP:0009699)2.44464314
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.44464314
38Oral leukoplakia (HP:0002745)2.44205954
39Abnormality of the distal phalanges of the toes (HP:0010182)2.44110958
40Testicular atrophy (HP:0000029)2.42735931
41Distal lower limb muscle weakness (HP:0009053)2.40787621
42Increased intramyocellular lipid droplets (HP:0012240)2.38549535
43Myelodysplasia (HP:0002863)2.34980607
44Ectopic kidney (HP:0000086)2.34335789
45Respiratory difficulties (HP:0002880)2.33521527
46Aplasia/Hypoplasia of the patella (HP:0006498)2.32475398
47Ragged-red muscle fibers (HP:0003200)2.31851824
48Abnormal number of incisors (HP:0011064)2.31644302
49Secondary amenorrhea (HP:0000869)2.29984951
50Abnormality of the anterior horn cell (HP:0006802)2.28573687
51Degeneration of anterior horn cells (HP:0002398)2.28573687
52Vertebral compression fractures (HP:0002953)2.26543826
53Microretrognathia (HP:0000308)2.26484697
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25213397
55Abnormality of the labia minora (HP:0012880)2.23434933
56Long eyelashes (HP:0000527)2.23300070
57Premature graying of hair (HP:0002216)2.22283333
58Agnosia (HP:0010524)2.21500954
59Distal lower limb amyotrophy (HP:0008944)2.19332461
60Short nail (HP:0001799)2.17322654
61Renal Fanconi syndrome (HP:0001994)2.16776896
62Increased nuchal translucency (HP:0010880)2.16104645
63Neoplasm of the pancreas (HP:0002894)2.15743704
64Small intestinal stenosis (HP:0012848)2.15218571
65Duodenal stenosis (HP:0100867)2.15218571
66Breast hypoplasia (HP:0003187)2.13373884
67Absent thumb (HP:0009777)2.13101567
6811 pairs of ribs (HP:0000878)2.12972632
69Astrocytoma (HP:0009592)2.11737263
70Abnormality of the astrocytes (HP:0100707)2.11737263
71Abnormality of the carotid arteries (HP:0005344)2.10929867
72Bone marrow hypocellularity (HP:0005528)2.10878472
73Absent radius (HP:0003974)2.10390225
74Abnormality of the fetal cardiovascular system (HP:0010948)2.09992403
75Abnormal umbilical cord blood vessels (HP:0011403)2.09992403
76Single umbilical artery (HP:0001195)2.09992403
77Renal duplication (HP:0000075)2.09240602
78Preauricular skin tag (HP:0000384)2.08458069
79Increased muscle lipid content (HP:0009058)2.07749057
80Abnormalities of placenta or umbilical cord (HP:0001194)2.06342017
81Tracheoesophageal fistula (HP:0002575)2.05000913
82Aplastic anemia (HP:0001915)2.04427094
83Glioma (HP:0009733)2.04341870
84Neoplasm of head and neck (HP:0012288)2.04227702
85Esophageal neoplasm (HP:0100751)2.04227702
86Basal cell carcinoma (HP:0002671)2.03479411
87Proximal placement of thumb (HP:0009623)2.03265020
88Sensory axonal neuropathy (HP:0003390)2.03052664
89Sloping forehead (HP:0000340)2.01967415
90Abnormality of the fingertips (HP:0001211)2.01696375
91Villous atrophy (HP:0011473)2.01597151
92Abnormality of small intestinal villus morphology (HP:0011472)2.01597151
93Abnormal lung lobation (HP:0002101)2.00200695
94Deviation of the thumb (HP:0009603)1.99082437
95Cellular immunodeficiency (HP:0005374)1.98935826
96Absent forearm bone (HP:0003953)1.98813620
97Aplasia involving forearm bones (HP:0009822)1.98813620
98Skin tags (HP:0010609)1.98736570
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97928726
100Abnormality of glycolysis (HP:0004366)1.97809315
101Atresia of the external auditory canal (HP:0000413)1.97069106
102Trismus (HP:0000211)1.96150187
103Reduced antithrombin III activity (HP:0001976)1.95286292
104Spastic diplegia (HP:0001264)1.94983492
105Cholelithiasis (HP:0001081)1.94698707
106Glossoptosis (HP:0000162)1.94127266
107Neoplasm of the oral cavity (HP:0100649)1.93443069
108Nonimmune hydrops fetalis (HP:0001790)1.92341563
109Spinal rigidity (HP:0003306)1.92144670
110Neoplasm of striated muscle (HP:0009728)1.91973754
111Amaurosis fugax (HP:0100576)1.89408911
112Achilles tendon contracture (HP:0001771)1.89221774
113Premature ovarian failure (HP:0008209)1.88701381
114Squamous cell carcinoma (HP:0002860)1.88239366
115Carpal bone hypoplasia (HP:0001498)1.87678790
116Pallor (HP:0000980)1.86034583
117Macrocytic anemia (HP:0001972)1.85453678
118Cerebral hypomyelination (HP:0006808)1.85100740
119Insomnia (HP:0100785)1.84386922
120Thrombocytosis (HP:0001894)1.83985222
121Cafe-au-lait spot (HP:0000957)1.82568313
122Triphalangeal thumb (HP:0001199)1.82077930
123Short middle phalanx of the 5th finger (HP:0004220)1.81974527
124Nephroblastoma (Wilms tumor) (HP:0002667)1.81783279
125Facial hemangioma (HP:0000329)1.81137806
126Abnormality of reticulocytes (HP:0004312)1.81029959
127Abnormal trabecular bone morphology (HP:0100671)1.79633530
128Missing ribs (HP:0000921)1.79123527
129Type I transferrin isoform profile (HP:0003642)1.78215211
130Reticulocytosis (HP:0001923)1.78122805
131Abnormality of the duodenum (HP:0002246)1.77746643
132Hypoplasia of the pons (HP:0012110)1.76156041
133Slender long bone (HP:0003100)1.74122962
134Lymphoma (HP:0002665)1.73821491
135Clubbing of toes (HP:0100760)1.73693313
136Increased serum pyruvate (HP:0003542)1.73454574
137Supernumerary spleens (HP:0009799)1.72931909
138Angiofibromas (HP:0010615)1.72909779
139Adenoma sebaceum (HP:0009720)1.72909779
140Hyperacusis (HP:0010780)1.72662330
141Long palpebral fissure (HP:0000637)1.72354265
142Broad thumb (HP:0011304)1.70428106
143Embryonal renal neoplasm (HP:0011794)1.69052811
144Short thumb (HP:0009778)1.68752040
145Sparse eyelashes (HP:0000653)1.68266499
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68152416
147Cleft eyelid (HP:0000625)1.67629187
148Abnormality of pyrimidine metabolism (HP:0004353)1.66402870
149High pitched voice (HP:0001620)1.65980287
150Microglossia (HP:0000171)1.65608055
151Dysphonia (HP:0001618)1.65198705
152Abnormality of the columella (HP:0009929)1.64933306
153Abnormality of the umbilical cord (HP:0010881)1.64705526
154Abnormality of DNA repair (HP:0003254)1.64364138
155Abnormality of the pons (HP:0007361)1.63339077
156Pancytopenia (HP:0001876)1.63330840
157Abnormal gallbladder morphology (HP:0012437)1.62843202
158Sparse lateral eyebrow (HP:0005338)1.62694004
159Overlapping toe (HP:0001845)1.62348569
160Progressive muscle weakness (HP:0003323)1.62031364
161Microvesicular hepatic steatosis (HP:0001414)1.61955902
162Neoplasm of the rectum (HP:0100743)1.61930372
163Distal upper limb amyotrophy (HP:0007149)1.61883705
164Upper limb amyotrophy (HP:0009129)1.61883705
165Breech presentation (HP:0001623)1.61081347
166Hypokinesia (HP:0002375)1.60840913
167Abnormality of the gallbladder (HP:0005264)1.60231010
168Deep philtrum (HP:0002002)1.60201274
169Choanal atresia (HP:0000453)1.59450078
170Gastrointestinal carcinoma (HP:0002672)1.59255302
171Reduced subcutaneous adipose tissue (HP:0003758)1.56659025
172Exercise intolerance (HP:0003546)1.56132199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.89431107
2PBK3.85061043
3CDK123.80444038
4CDC73.37210401
5SMG13.19028756
6WEE13.10385815
7VRK22.96204734
8TLK12.63041992
9MAP3K102.46578427
10NEK22.39395381
11EEF2K2.21924995
12SRPK12.11914227
13TAOK22.11167979
14TSSK62.07637047
15MKNK22.01144258
16EIF2AK11.97974632
17ACVR1B1.89056741
18CDK71.88465198
19TTK1.84683841
20RPS6KA41.84620559
21ZAK1.83318793
22BRD41.74295686
23PLK11.72111024
24BRSK21.70342785
25MKNK11.70231968
26PRPF4B1.61506733
27EIF2AK31.60749489
28VRK11.59668016
29ATR1.57347435
30STK101.56164061
31PLK41.51916139
32SIK11.51600866
33PASK1.51519024
34CDK41.50376019
35NME21.46867138
36MST1R1.39341672
37TAF11.38732943
38DYRK31.38566245
39AURKB1.37565252
40RPS6KB21.36274558
41EPHA21.36252196
42CHEK21.31571970
43NME11.30627607
44MAP3K81.28534404
45CHEK11.26621659
46ICK1.19364044
47MAP3K111.17768418
48PLK31.15846098
49PAK41.11552982
50MAP4K11.10045981
51FLT31.05217072
52PIM11.04959472
53TRIB31.04839271
54TGFBR11.01315470
55TESK21.00525889
56AURKA0.99575166
57ALK0.97826628
58STK160.97125100
59LATS10.94383616
60STK40.91706529
61CDK20.90834507
62MTOR0.88974037
63ATM0.88966607
64EIF2AK20.87150252
65ZAP700.83898997
66CDK80.83370884
67TTN0.80738785
68PKN20.80486047
69JAK30.79633794
70BRAF0.75404196
71STK30.75249607
72MST40.74928361
73PIM20.73974162
74SIK30.73586772
75FGFR40.73569263
76GRK60.72412543
77LMTK20.70926182
78NEK10.69885694
79PDK20.67693744
80ERBB40.65459526
81BRSK10.65362068
82CSF1R0.65145809
83LATS20.64261686
84SCYL20.64237039
85BTK0.62968364
86ARAF0.61799978
87CDK10.61324801
88CDK60.60773224
89AKT20.58566357
90RIPK10.58362083
91TESK10.58183093
92PTK20.57998630
93RPS6KA50.57837374
94DAPK10.56873602
95CSNK2A20.56760974
96BCKDK0.56190708
97PAK10.56111927
98MAPK110.56092593
99MET0.55232036
100CLK10.54375711
101BMX0.54158247
102CHUK0.54081693
103PDGFRA0.53505248
104NLK0.52569232
105ILK0.51246371
106MAP2K30.49921090
107LRRK20.46550111
108ERN10.45241694
109CSNK2A10.44457091
110CDK190.43507282
111MAP3K140.40585573
112ITK0.40404951
113YES10.39522463
114PRKDC0.39472889
115IKBKB0.39383822
116FGFR10.39279199
117MAP3K30.38921418
118CDK90.38516915
119MELK0.38157768
120DAPK30.37548983
121TEC0.37437365
122CSNK1E0.35490424
123RPS6KA60.34615268
124MAPKAPK30.33396583
125MAPKAPK20.32963779
126AKT10.32529029
127MAPK140.32469212
128PAK20.31373489
129IRAK30.30823281
130AKT30.30586763
131ABL20.30510818
132PTK60.29896745
133PRKCI0.27662835
134MAP3K90.27461374
135MAP2K20.27131244
136RAF10.26812631

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35752840
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06176893
3One carbon pool by folate_Homo sapiens_hsa006703.60834368
4Mismatch repair_Homo sapiens_hsa034303.53120023
5Spliceosome_Homo sapiens_hsa030403.24087594
6RNA transport_Homo sapiens_hsa030133.21443424
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05204074
8Base excision repair_Homo sapiens_hsa034102.81350844
9Homologous recombination_Homo sapiens_hsa034402.75807074
10RNA polymerase_Homo sapiens_hsa030202.72707825
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68496948
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67525270
13Ribosome_Homo sapiens_hsa030102.56979214
14Cell cycle_Homo sapiens_hsa041102.52204695
15Nucleotide excision repair_Homo sapiens_hsa034202.36952640
16Fanconi anemia pathway_Homo sapiens_hsa034602.33636000
17Pyrimidine metabolism_Homo sapiens_hsa002402.17473708
18Non-homologous end-joining_Homo sapiens_hsa034502.06607106
19mRNA surveillance pathway_Homo sapiens_hsa030152.04671748
20Proteasome_Homo sapiens_hsa030501.98369641
21Carbon metabolism_Homo sapiens_hsa012001.90003896
22RNA degradation_Homo sapiens_hsa030181.74144921
23Basal transcription factors_Homo sapiens_hsa030221.63512028
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60731937
25Selenocompound metabolism_Homo sapiens_hsa004501.52481120
26p53 signaling pathway_Homo sapiens_hsa041151.50153036
27Systemic lupus erythematosus_Homo sapiens_hsa053221.44605880
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.43784224
29Sulfur relay system_Homo sapiens_hsa041221.36494154
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28615013
31Epstein-Barr virus infection_Homo sapiens_hsa051691.23791756
32Herpes simplex infection_Homo sapiens_hsa051681.22385118
33Pyruvate metabolism_Homo sapiens_hsa006201.20563934
34Viral carcinogenesis_Homo sapiens_hsa052031.12990288
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10246174
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08467789
37Purine metabolism_Homo sapiens_hsa002301.03363377
38Vitamin B6 metabolism_Homo sapiens_hsa007501.02825891
39HTLV-I infection_Homo sapiens_hsa051660.97510185
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.92523946
41MicroRNAs in cancer_Homo sapiens_hsa052060.87868264
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86919141
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86897333
44Small cell lung cancer_Homo sapiens_hsa052220.86853730
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85898468
46Antigen processing and presentation_Homo sapiens_hsa046120.84273589
47Biosynthesis of amino acids_Homo sapiens_hsa012300.81353239
48Basal cell carcinoma_Homo sapiens_hsa052170.81290686
49Primary immunodeficiency_Homo sapiens_hsa053400.79367916
50Fatty acid elongation_Homo sapiens_hsa000620.78921167
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77764764
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.76805540
53Thyroid cancer_Homo sapiens_hsa052160.75016756
54Legionellosis_Homo sapiens_hsa051340.73382037
55Pentose phosphate pathway_Homo sapiens_hsa000300.73177921
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.72335415
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69980449
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69969738
59Folate biosynthesis_Homo sapiens_hsa007900.69937524
60Glutathione metabolism_Homo sapiens_hsa004800.69618585
61Measles_Homo sapiens_hsa051620.67097404
62Lysine degradation_Homo sapiens_hsa003100.63211015
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61360549
64Steroid biosynthesis_Homo sapiens_hsa001000.59365219
65Apoptosis_Homo sapiens_hsa042100.58549206
66Hippo signaling pathway_Homo sapiens_hsa043900.55324357
67Hepatitis B_Homo sapiens_hsa051610.54851092
68Hematopoietic cell lineage_Homo sapiens_hsa046400.54461404
69N-Glycan biosynthesis_Homo sapiens_hsa005100.52939675
70Acute myeloid leukemia_Homo sapiens_hsa052210.52710773
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52336526
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52131709
73Chronic myeloid leukemia_Homo sapiens_hsa052200.51700041
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51443445
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50992413
76Arginine biosynthesis_Homo sapiens_hsa002200.50785827
77TGF-beta signaling pathway_Homo sapiens_hsa043500.50264207
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48312915
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48190881
80Influenza A_Homo sapiens_hsa051640.47184810
81Pancreatic cancer_Homo sapiens_hsa052120.46542804
82Huntingtons disease_Homo sapiens_hsa050160.45049149
83Colorectal cancer_Homo sapiens_hsa052100.42598606
84Notch signaling pathway_Homo sapiens_hsa043300.42592892
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42538626
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42283806
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.41051476
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40035232
89Metabolic pathways_Homo sapiens_hsa011000.39171854
90Bladder cancer_Homo sapiens_hsa052190.37041241
91Parkinsons disease_Homo sapiens_hsa050120.36375381
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35640225
93Other glycan degradation_Homo sapiens_hsa005110.35551320
94Alcoholism_Homo sapiens_hsa050340.35356110
95Prostate cancer_Homo sapiens_hsa052150.35327622
96Oocyte meiosis_Homo sapiens_hsa041140.35022011
97Vibrio cholerae infection_Homo sapiens_hsa051100.34065053
98Shigellosis_Homo sapiens_hsa051310.33635927
99Pathways in cancer_Homo sapiens_hsa052000.32754077
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.31715264
101Hedgehog signaling pathway_Homo sapiens_hsa043400.31475417
102Propanoate metabolism_Homo sapiens_hsa006400.30243989
103Oxidative phosphorylation_Homo sapiens_hsa001900.29604719
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28793786
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26572863
106Melanoma_Homo sapiens_hsa052180.26225682
107Arginine and proline metabolism_Homo sapiens_hsa003300.26186903
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26133530
109Fructose and mannose metabolism_Homo sapiens_hsa000510.25786358
110Lysosome_Homo sapiens_hsa041420.24952820
111Wnt signaling pathway_Homo sapiens_hsa043100.24716820
112Asthma_Homo sapiens_hsa053100.24036121
113HIF-1 signaling pathway_Homo sapiens_hsa040660.23574045
114Galactose metabolism_Homo sapiens_hsa000520.23542496
115Proteoglycans in cancer_Homo sapiens_hsa052050.23171885
116Renin-angiotensin system_Homo sapiens_hsa046140.22636768
117Phenylalanine metabolism_Homo sapiens_hsa003600.22443747
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22384551
119Adherens junction_Homo sapiens_hsa045200.22203144
120Leishmaniasis_Homo sapiens_hsa051400.22127849
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22055398
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21658011
123Endometrial cancer_Homo sapiens_hsa052130.20818187
124Prion diseases_Homo sapiens_hsa050200.20268534
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19923105
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19826456
127Glioma_Homo sapiens_hsa052140.18536888
128Non-small cell lung cancer_Homo sapiens_hsa052230.18278439
129FoxO signaling pathway_Homo sapiens_hsa040680.18016259
130mTOR signaling pathway_Homo sapiens_hsa041500.17777629
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17636228
132T cell receptor signaling pathway_Homo sapiens_hsa046600.16949710
133Protein export_Homo sapiens_hsa030600.16344536

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