METTL14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)4.00906763
2centriole replication (GO:0007099)3.96445828
3regulation of DNA endoreduplication (GO:0032875)3.84576579
4DNA ligation (GO:0006266)3.50369879
5mRNA splice site selection (GO:0006376)3.49986305
6respiratory chain complex IV assembly (GO:0008535)3.42305440
7response to pheromone (GO:0019236)3.38516986
8establishment of protein localization to mitochondrial membrane (GO:0090151)3.34537725
9DNA integration (GO:0015074)3.32756830
10histone exchange (GO:0043486)3.30169711
11microtubule depolymerization (GO:0007019)3.28857625
12platelet dense granule organization (GO:0060155)3.27900595
13water-soluble vitamin biosynthetic process (GO:0042364)3.27173026
14RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26953317
15regulation of centriole replication (GO:0046599)3.21703275
16lateral sprouting from an epithelium (GO:0060601)3.20791457
17female gonad development (GO:0008585)3.18823395
18epithelial cilium movement (GO:0003351)3.16913211
19neuron cell-cell adhesion (GO:0007158)3.15994321
20behavioral response to nicotine (GO:0035095)3.15912005
21histone mRNA metabolic process (GO:0008334)3.15746732
22regulation of hexokinase activity (GO:1903299)3.14431324
23regulation of glucokinase activity (GO:0033131)3.14431324
24meiotic chromosome segregation (GO:0045132)3.11729633
25intraciliary transport (GO:0042073)3.07297827
26cytochrome complex assembly (GO:0017004)3.07203143
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.06221223
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06221223
29cerebral cortex radially oriented cell migration (GO:0021799)3.00587245
30establishment of integrated proviral latency (GO:0075713)2.97975538
31cullin deneddylation (GO:0010388)2.97767335
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96679394
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96679394
34isotype switching (GO:0045190)2.96679394
35kinetochore organization (GO:0051383)2.96170678
36recombinational repair (GO:0000725)2.94106586
37kinetochore assembly (GO:0051382)2.93539846
38protein prenylation (GO:0018342)2.93457768
39prenylation (GO:0097354)2.93457768
40double-strand break repair via homologous recombination (GO:0000724)2.92690624
41signal peptide processing (GO:0006465)2.92320222
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89939120
43cell proliferation in forebrain (GO:0021846)2.88694928
44mitochondrial respiratory chain complex assembly (GO:0033108)2.88475972
45DNA damage response, detection of DNA damage (GO:0042769)2.88095563
46postreplication repair (GO:0006301)2.86497272
47cranial nerve morphogenesis (GO:0021602)2.85917380
48positive regulation of histone H3-K4 methylation (GO:0051571)2.85714212
49protein complex biogenesis (GO:0070271)2.85272910
50presynaptic membrane assembly (GO:0097105)2.85018486
51DNA strand renaturation (GO:0000733)2.84764985
52resolution of meiotic recombination intermediates (GO:0000712)2.84731421
53ribosome assembly (GO:0042255)2.82633984
54single strand break repair (GO:0000012)2.80269380
55regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.80109129
56negative regulation of DNA-dependent DNA replication (GO:2000104)2.78512954
57startle response (GO:0001964)2.77435269
58branched-chain amino acid catabolic process (GO:0009083)2.76413917
59regulation of nuclear cell cycle DNA replication (GO:0033262)2.76279470
60microtubule polymerization or depolymerization (GO:0031109)2.75210302
61synapsis (GO:0007129)2.74471341
62acrosome reaction (GO:0007340)2.74339422
63neural tube formation (GO:0001841)2.74067259
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72417214
65protein deneddylation (GO:0000338)2.72350931
66lymphoid progenitor cell differentiation (GO:0002320)2.72322895
67cellular ketone body metabolic process (GO:0046950)2.71058022
68cilium morphogenesis (GO:0060271)2.71013073
69regulation of mRNA splicing, via spliceosome (GO:0048024)2.70580562
70central nervous system myelination (GO:0022010)2.68424749
71axon ensheathment in central nervous system (GO:0032291)2.68424749
72spermatid nucleus differentiation (GO:0007289)2.67527654
73V(D)J recombination (GO:0033151)2.67055057
74positive regulation of DNA-dependent DNA replication (GO:2000105)2.66374398
75anterograde synaptic vesicle transport (GO:0048490)2.66146828
76mesonephros development (GO:0001823)2.65709932
77histone H2A acetylation (GO:0043968)2.65608408
78ncRNA catabolic process (GO:0034661)2.63131082
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62736345
80limb bud formation (GO:0060174)2.61753877
81head development (GO:0060322)2.60012785
82regulation of telomere maintenance (GO:0032204)2.58630684
83histone H2B ubiquitination (GO:0033523)2.58089188
84organelle disassembly (GO:1903008)2.56960127
85regulation of meiosis I (GO:0060631)2.55870535
86mismatch repair (GO:0006298)2.55744811
87mitotic sister chromatid cohesion (GO:0007064)2.55245394
88pattern specification involved in kidney development (GO:0061004)2.54890081
89rRNA methylation (GO:0031167)2.54411238
90DNA deamination (GO:0045006)2.54112938
91cilium organization (GO:0044782)2.53634902
92histone mRNA catabolic process (GO:0071044)2.53602892
93regulation of cilium movement (GO:0003352)2.52208439
94NADH dehydrogenase complex assembly (GO:0010257)2.51624763
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51624763
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.51624763
97proteasome assembly (GO:0043248)2.50566516
98DNA unwinding involved in DNA replication (GO:0006268)2.50359683
99DNA replication-dependent nucleosome organization (GO:0034723)2.50045180
100DNA replication-dependent nucleosome assembly (GO:0006335)2.50045180
101protein K6-linked ubiquitination (GO:0085020)2.49676938
102protein-cofactor linkage (GO:0018065)2.49639144
103translesion synthesis (GO:0019985)2.48893235
104postsynaptic membrane organization (GO:0001941)2.47759007
105somatic diversification of immunoglobulins (GO:0016445)2.47663346
106establishment of protein localization to Golgi (GO:0072600)2.47628040
107cilium movement (GO:0003341)2.47513965
108regulation of mitotic spindle checkpoint (GO:1903504)2.46355600
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46355600
110cilium assembly (GO:0042384)2.45655349
111ketone body metabolic process (GO:1902224)2.44803731
112glucosamine-containing compound catabolic process (GO:1901072)2.44395817
113DNA synthesis involved in DNA repair (GO:0000731)2.44116141
114keratinocyte development (GO:0003334)2.43877585
115alternative mRNA splicing, via spliceosome (GO:0000380)2.41626399
116daunorubicin metabolic process (GO:0044597)2.40288157
117polyketide metabolic process (GO:0030638)2.40288157
118doxorubicin metabolic process (GO:0044598)2.40288157
119presynaptic membrane organization (GO:0097090)2.39285417
120righting reflex (GO:0060013)2.37863742
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.37739809
122termination of RNA polymerase III transcription (GO:0006386)2.37739809
123nonmotile primary cilium assembly (GO:0035058)2.36304462
124non-recombinational repair (GO:0000726)2.35133602
125double-strand break repair via nonhomologous end joining (GO:0006303)2.35133602
126telomere maintenance via semi-conservative replication (GO:0032201)2.33877008
127CENP-A containing nucleosome assembly (GO:0034080)2.32654706
128regulation of mRNA processing (GO:0050684)2.32288475
129positive regulation of mRNA processing (GO:0050685)2.31394216
130positive regulation of synapse assembly (GO:0051965)2.29019013
131transcription elongation from RNA polymerase I promoter (GO:0006362)2.28085978
132DNA replication initiation (GO:0006270)2.27364079
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.26599748
134protein neddylation (GO:0045116)2.26479623
135regulation of respiratory system process (GO:0044065)2.26079856
136chromatin remodeling at centromere (GO:0031055)2.25959205
137DNA strand elongation (GO:0022616)2.25761993
138reciprocal DNA recombination (GO:0035825)2.25582471
139reciprocal meiotic recombination (GO:0007131)2.25582471
140DNA double-strand break processing (GO:0000729)2.25167672
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.21992020
142histone H3-K4 trimethylation (GO:0080182)2.21270073
143regulation of double-strand break repair via homologous recombination (GO:0010569)2.19824719
144establishment of viral latency (GO:0019043)2.19709722
145DNA strand elongation involved in DNA replication (GO:0006271)2.19099366
146regulation of mRNA 3-end processing (GO:0031440)2.18977323
147telomere maintenance via telomere lengthening (GO:0010833)2.17533856
148nucleotide-excision repair, DNA gap filling (GO:0006297)2.15471024
149negative regulation of neurotransmitter transport (GO:0051589)2.14520353
150negative regulation of DNA recombination (GO:0045910)2.13984994
151regulation of mRNA metabolic process (GO:1903311)2.13482816
152regulation of timing of cell differentiation (GO:0048505)2.13421257
153protein heterotetramerization (GO:0051290)2.13149942
154neurotransmitter uptake (GO:0001504)2.13092675
155DNA catabolic process, exonucleolytic (GO:0000738)2.13048564
156nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.13020061
157mitotic recombination (GO:0006312)2.12877062
158centriole assembly (GO:0098534)2.12270798
159DNA replication checkpoint (GO:0000076)2.11477901
160DNA replication-independent nucleosome organization (GO:0034724)2.11323199
161DNA replication-independent nucleosome assembly (GO:0006336)2.11323199
162regulation of helicase activity (GO:0051095)2.11322136
163L-fucose catabolic process (GO:0042355)2.09770231
164fucose catabolic process (GO:0019317)2.09770231
165L-fucose metabolic process (GO:0042354)2.09770231
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.09297023
167spliceosomal snRNP assembly (GO:0000387)2.07993896
168somatic recombination of immunoglobulin gene segments (GO:0016447)2.07646312
169retina layer formation (GO:0010842)2.06689753
170spinal cord motor neuron differentiation (GO:0021522)2.06640503
171telomere maintenance via recombination (GO:0000722)2.06178801
172urogenital system development (GO:0001655)2.04626095
173regulation of development, heterochronic (GO:0040034)2.04062129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.41269298
2GBX2_23144817_ChIP-Seq_PC3_Human3.84031865
3EZH2_22144423_ChIP-Seq_EOC_Human3.57334153
4ZNF274_21170338_ChIP-Seq_K562_Hela2.89735180
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.77499767
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.74242197
7FUS_26573619_Chip-Seq_HEK293_Human2.50736153
8* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48016361
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42498200
10ELK1_19687146_ChIP-ChIP_HELA_Human2.40079675
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34727777
12EWS_26573619_Chip-Seq_HEK293_Human2.20930306
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19002995
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13573196
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10367649
16TAF15_26573619_Chip-Seq_HEK293_Human2.09594728
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08348452
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.07057364
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05936839
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03554423
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02300475
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.87178603
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.86919614
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86859896
25VDR_23849224_ChIP-Seq_CD4+_Human1.86644394
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86394196
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82844963
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.81069293
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80659688
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80467196
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77810129
32P300_19829295_ChIP-Seq_ESCs_Human1.76988824
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71998270
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.69177296
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68835287
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67673384
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67083059
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66189811
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65107091
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64816160
41RNF2_27304074_Chip-Seq_NSC_Mouse1.64506416
42VDR_22108803_ChIP-Seq_LS180_Human1.63557644
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60331851
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57810990
45MYC_18940864_ChIP-ChIP_HL60_Human1.57774761
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.54724941
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.54707812
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.53340192
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51952711
50* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51790811
51* CBP_20019798_ChIP-Seq_JUKART_Human1.51790811
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.51604347
53* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51398120
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51032152
55P53_22387025_ChIP-Seq_ESCs_Mouse1.50275724
56IGF1R_20145208_ChIP-Seq_DFB_Human1.50209374
57IRF1_19129219_ChIP-ChIP_H3396_Human1.43885852
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43660308
59FOXP3_21729870_ChIP-Seq_TREG_Human1.43315682
60* CMYC_18555785_Chip-Seq_ESCs_Mouse1.42261940
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41311359
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40021906
63* STAT3_18555785_Chip-Seq_ESCs_Mouse1.38480611
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37247595
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36549261
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.36396221
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.35900673
68ER_23166858_ChIP-Seq_MCF-7_Human1.35310337
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35211098
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35198124
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.34486066
72SMAD4_21799915_ChIP-Seq_A2780_Human1.34179505
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.33137763
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32620053
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31561328
76* P300_18555785_Chip-Seq_ESCs_Mouse1.31366691
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30853780
78* NMYC_18555785_Chip-Seq_ESCs_Mouse1.29234315
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24751201
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.24688321
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24352338
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23802693
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23163486
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22768225
85* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21699819
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.21380299
87AR_21572438_ChIP-Seq_LNCaP_Human1.21353839
88RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20237286
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20170468
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19952879
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19269615
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18655270
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.18492961
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18470576
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.18234678
96KLF4_18555785_Chip-Seq_ESCs_Mouse1.17866761
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17662002
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16572999
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16311961
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16142161
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16142161
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15677456
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15392030
104BCAT_22108803_ChIP-Seq_LS180_Human1.15247053
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14799192
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14209642
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14148838
108NANOG_19829295_ChIP-Seq_ESCs_Human1.13446986
109SOX2_19829295_ChIP-Seq_ESCs_Human1.13446986
110STAT3_23295773_ChIP-Seq_U87_Human1.12734644
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.12321043
112SOX9_26525672_Chip-Seq_HEART_Mouse1.12050139
113AR_25329375_ChIP-Seq_VCAP_Human1.11994737
114* CTCF_18555785_Chip-Seq_ESCs_Mouse1.11922504
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11798141
116TCF4_22108803_ChIP-Seq_LS180_Human1.11268951
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10526355
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.10488568
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10103193
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09937141
121ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09840503
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09061143
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08285051
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.07896087
125TCF4_23295773_ChIP-Seq_U87_Human1.07197396
126RUNX2_22187159_ChIP-Seq_PCA_Human1.05712366
127TP53_22573176_ChIP-Seq_HFKS_Human1.04781423
128* PU1_27457419_Chip-Seq_LIVER_Mouse1.02809350
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.02324822
130SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01973369
131ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01842084
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01588474
133RNF2_27304074_Chip-Seq_ESCs_Mouse1.01042660
134SOX2_16153702_ChIP-ChIP_HESCs_Human1.00629592
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00231604
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99420365
137JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99077952
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97742884
139CDX2_22108803_ChIP-Seq_LS180_Human0.97388897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.12510547
2MP0008057_abnormal_DNA_replication3.38031294
3MP0006292_abnormal_olfactory_placode3.31902966
4MP0003136_yellow_coat_color3.08426642
5MP0005409_darkened_coat_color2.74148463
6MP0003880_abnormal_central_pattern2.65575305
7MP0002102_abnormal_ear_morphology2.52584062
8MP0000566_synostosis2.42884557
9MP0000372_irregular_coat_pigmentation2.27639303
10MP0008058_abnormal_DNA_repair2.22934067
11MP0005084_abnormal_gallbladder_morpholo2.12083103
12MP0008995_early_reproductive_senescence2.11658985
13MP0003195_calcinosis2.09692711
14MP0010094_abnormal_chromosome_stability2.05235558
15MP0003718_maternal_effect1.95370282
16MP0009697_abnormal_copulation1.83084833
17MP0008877_abnormal_DNA_methylation1.82996279
18MP0002928_abnormal_bile_duct1.80027522
19MP0002938_white_spotting1.79408522
20MP0003787_abnormal_imprinting1.78514939
21MP0005174_abnormal_tail_pigmentation1.75608768
22MP0003121_genomic_imprinting1.74811465
23MP0001529_abnormal_vocalization1.74520442
24MP0008789_abnormal_olfactory_epithelium1.65972039
25MP0000383_abnormal_hair_follicle1.65418892
26MP0005423_abnormal_somatic_nervous1.61240296
27MP0005171_absent_coat_pigmentation1.59711491
28MP0001486_abnormal_startle_reflex1.59603782
29MP0003111_abnormal_nucleus_morphology1.57814615
30MP0000778_abnormal_nervous_system1.54953891
31MP0005646_abnormal_pituitary_gland1.49697192
32MP0005410_abnormal_fertilization1.44883070
33MP0006072_abnormal_retinal_apoptosis1.43366567
34MP0004142_abnormal_muscle_tone1.43158174
35MP0004742_abnormal_vestibular_system1.42822492
36MP0001929_abnormal_gametogenesis1.40741642
37MP0000049_abnormal_middle_ear1.39012176
38MP0002638_abnormal_pupillary_reflex1.38960070
39MP0006276_abnormal_autonomic_nervous1.36845319
40MP0005645_abnormal_hypothalamus_physiol1.36196309
41MP0000569_abnormal_digit_pigmentation1.35113046
42MP0003938_abnormal_ear_development1.34564394
43MP0001905_abnormal_dopamine_level1.31874476
44MP0000015_abnormal_ear_pigmentation1.30466773
45MP0002163_abnormal_gland_morphology1.29935109
46MP0000026_abnormal_inner_ear1.28840193
47MP0000427_abnormal_hair_cycle1.28490870
48MP0000631_abnormal_neuroendocrine_gland1.27524605
49MP0002184_abnormal_innervation1.27239349
50MP0002653_abnormal_ependyma_morphology1.26228977
51MP0002272_abnormal_nervous_system1.24965024
52MP0005379_endocrine/exocrine_gland_phen1.24127697
53MP0009046_muscle_twitch1.22454481
54MP0008007_abnormal_cellular_replicative1.21413113
55MP0001485_abnormal_pinna_reflex1.20972592
56MP0005248_abnormal_Harderian_gland1.19462614
57MP0002160_abnormal_reproductive_system1.18474026
58MP0009745_abnormal_behavioral_response1.17995172
59MP0002067_abnormal_sensory_capabilities1.17923887
60MP0002572_abnormal_emotion/affect_behav1.17772782
61MP0002751_abnormal_autonomic_nervous1.17541768
62MP0005551_abnormal_eye_electrophysiolog1.17174455
63MP0002876_abnormal_thyroid_physiology1.16087509
64MP0008932_abnormal_embryonic_tissue1.15530417
65MP0002234_abnormal_pharynx_morphology1.15327832
66MP0001968_abnormal_touch/_nociception1.15316014
67MP0003698_abnormal_male_reproductive1.15045476
68MP0004147_increased_porphyrin_level1.14555144
69MP0005389_reproductive_system_phenotype1.14236380
70MP0003635_abnormal_synaptic_transmissio1.13198761
71MP0002064_seizures1.12855817
72MP0002736_abnormal_nociception_after1.12382374
73MP0003252_abnormal_bile_duct1.12294380
74MP0002735_abnormal_chemical_nociception1.11701435
75MP0003077_abnormal_cell_cycle1.10759259
76MP0001293_anophthalmia1.09559995
77MP0002233_abnormal_nose_morphology1.09513980
78MP0000653_abnormal_sex_gland1.09448333
79MP0001919_abnormal_reproductive_system1.07579084
80MP0003937_abnormal_limbs/digits/tail_de1.06177384
81MP0005394_taste/olfaction_phenotype1.05134553
82MP0005499_abnormal_olfactory_system1.05134553
83MP0001324_abnormal_eye_pigmentation1.04063358
84MP0001963_abnormal_hearing_physiology1.03615721
85MP0002752_abnormal_somatic_nervous1.03580009
86MP0003122_maternal_imprinting1.03286795
87MP0004381_abnormal_hair_follicle1.03190610
88MP0003890_abnormal_embryonic-extraembry1.01685460
89MP0003123_paternal_imprinting1.00855119
90MP0000647_abnormal_sebaceous_gland1.00194545
91MP0001986_abnormal_taste_sensitivity0.99328971
92MP0006035_abnormal_mitochondrial_morpho0.98451742
93MP0003119_abnormal_digestive_system0.97477796
94MP0004133_heterotaxia0.96420297
95MP0003861_abnormal_nervous_system0.96046088
96MP0002063_abnormal_learning/memory/cond0.95177380
97MP0003693_abnormal_embryo_hatching0.94958138
98MP0002557_abnormal_social/conspecific_i0.93951401
99MP0004043_abnormal_pH_regulation0.92462212
100MP0002249_abnormal_larynx_morphology0.92139702
101MP0002095_abnormal_skin_pigmentation0.90622413
102MP0001286_abnormal_eye_development0.89912627
103MP0001764_abnormal_homeostasis0.89570707
104MP0001119_abnormal_female_reproductive0.88587029
105MP0004270_analgesia0.87951649
106MP0001440_abnormal_grooming_behavior0.87724796
107MP0010678_abnormal_skin_adnexa0.86268169
108MP0002210_abnormal_sex_determination0.84975934
109MP0005253_abnormal_eye_physiology0.84956950
110MP0002734_abnormal_mechanical_nocicepti0.83726939
111MP0002084_abnormal_developmental_patter0.83591368
112MP0003941_abnormal_skin_development0.83044073
113MP0009250_abnormal_appendicular_skeleto0.82978889
114MP0010030_abnormal_orbit_morphology0.82787596
115MP0002882_abnormal_neuron_morphology0.82451136
116MP0002090_abnormal_vision0.81323066
117MP0001984_abnormal_olfaction0.80677680
118MP0002396_abnormal_hematopoietic_system0.80168886
119MP0003385_abnormal_body_wall0.80156685
120MP0003786_premature_aging0.79474767
121MP0000490_abnormal_crypts_of0.77787080
122MP0003943_abnormal_hepatobiliary_system0.76970361
123MP0005075_abnormal_melanosome_morpholog0.76874971
124MP0002152_abnormal_brain_morphology0.75765509
125MP0004215_abnormal_myocardial_fiber0.75682161
126MP0003186_abnormal_redox_activity0.75105358
127MP0003755_abnormal_palate_morphology0.73582440
128MP0005395_other_phenotype0.73041717
129MP0003315_abnormal_perineum_morphology0.72736076
130MP0003567_abnormal_fetal_cardiomyocyte0.72556731
131MP0005195_abnormal_posterior_eye0.72241928
132MP0005391_vision/eye_phenotype0.72139438
133MP0005367_renal/urinary_system_phenotyp0.71672094
134MP0000516_abnormal_urinary_system0.71672094
135MP0005623_abnormal_meninges_morphology0.71648554
136MP0003011_delayed_dark_adaptation0.71121579
137MP0002138_abnormal_hepatobiliary_system0.70167004
138MP0003936_abnormal_reproductive_system0.69526446
139MP0002116_abnormal_craniofacial_bone0.69198780
140MP0006036_abnormal_mitochondrial_physio0.69161954
141MP0005386_behavior/neurological_phenoty0.68660245
142MP0004924_abnormal_behavior0.68660245
143MP0000955_abnormal_spinal_cord0.68391539
144MP0004957_abnormal_blastocyst_morpholog0.66519173
145MP0001145_abnormal_male_reproductive0.66224780

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.69219835
2Chromsome breakage (HP:0040012)4.56485017
3Colon cancer (HP:0003003)2.88238943
4Febrile seizures (HP:0002373)2.73115717
5Acute necrotizing encephalopathy (HP:0006965)2.55248413
6Bile duct proliferation (HP:0001408)2.55026739
7Abnormal biliary tract physiology (HP:0012439)2.55026739
8Duplicated collecting system (HP:0000081)2.53886329
9Lipid accumulation in hepatocytes (HP:0006561)2.53812237
10Septo-optic dysplasia (HP:0100842)2.53109793
11Abnormality of the renal cortex (HP:0011035)2.50587867
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.47932469
13Aplasia cutis congenita (HP:0001057)2.46660727
14Progressive macrocephaly (HP:0004481)2.45516230
15Duplication of thumb phalanx (HP:0009942)2.42818185
16Genital tract atresia (HP:0001827)2.42368642
17Short tibia (HP:0005736)2.42354703
18Abnormality of the preputium (HP:0100587)2.40304848
19Acute encephalopathy (HP:0006846)2.38886542
20Vaginal atresia (HP:0000148)2.38612823
21Focal motor seizures (HP:0011153)2.36899933
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.34314920
23Meckel diverticulum (HP:0002245)2.34035547
24Volvulus (HP:0002580)2.33134790
25Oligodactyly (hands) (HP:0001180)2.32331330
26Nephronophthisis (HP:0000090)2.31116021
27Abnormality of the ileum (HP:0001549)2.30971008
28Abnormality of the renal collecting system (HP:0004742)2.24319894
29Renal cortical cysts (HP:0000803)2.24186121
30Abnormality of chromosome stability (HP:0003220)2.23707560
31Methylmalonic acidemia (HP:0002912)2.23543897
32Abnormality of the labia minora (HP:0012880)2.23064551
33Nephroblastoma (Wilms tumor) (HP:0002667)2.21086611
34Increased CSF lactate (HP:0002490)2.19903878
35Mitochondrial inheritance (HP:0001427)2.19557609
36Abnormal ciliary motility (HP:0012262)2.18903045
37Chronic hepatic failure (HP:0100626)2.18375317
38Ectopic kidney (HP:0000086)2.18159414
39True hermaphroditism (HP:0010459)2.15769697
40Hyperventilation (HP:0002883)2.15668428
41Aplasia involving forearm bones (HP:0009822)2.13888794
42Absent forearm bone (HP:0003953)2.13888794
43Hyperglycinemia (HP:0002154)2.12436242
44Protruding tongue (HP:0010808)2.11355926
45Fair hair (HP:0002286)2.09586908
46Optic nerve hypoplasia (HP:0000609)2.09413479
47Absent septum pellucidum (HP:0001331)2.08610461
48Abnormal mitochondria in muscle tissue (HP:0008316)2.08259462
49Embryonal renal neoplasm (HP:0011794)2.06891160
50Medial flaring of the eyebrow (HP:0010747)2.04531681
51Absent radius (HP:0003974)2.03729073
52Tubulointerstitial nephritis (HP:0001970)2.03656812
53Stomach cancer (HP:0012126)2.02242465
54Sloping forehead (HP:0000340)2.01922295
55Abnormality of midbrain morphology (HP:0002418)2.01538501
56Molar tooth sign on MRI (HP:0002419)2.01538501
57Preaxial hand polydactyly (HP:0001177)2.01011316
58Broad-based gait (HP:0002136)2.00780271
59Poor coordination (HP:0002370)1.99524316
60Hyperinsulinemic hypoglycemia (HP:0000825)1.99376925
61Absent speech (HP:0001344)1.98405625
62Abnormal number of incisors (HP:0011064)1.96045297
63Abnormality of the septum pellucidum (HP:0007375)1.94864652
64Abnormal lung lobation (HP:0002101)1.94752337
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.94238993
66Small intestinal stenosis (HP:0012848)1.93075106
67Duodenal stenosis (HP:0100867)1.93075106
68Severe visual impairment (HP:0001141)1.92498213
69Attenuation of retinal blood vessels (HP:0007843)1.92401500
70Abnormal respiratory motile cilium morphology (HP:0005938)1.92246983
71Abnormal respiratory epithelium morphology (HP:0012253)1.92246983
72Abolished electroretinogram (ERG) (HP:0000550)1.92025716
73Postaxial hand polydactyly (HP:0001162)1.91199087
74Triphalangeal thumb (HP:0001199)1.89048717
75Sclerocornea (HP:0000647)1.87497895
76Renal Fanconi syndrome (HP:0001994)1.87424527
77Oligodactyly (HP:0012165)1.87378055
78Anomalous pulmonary venous return (HP:0010772)1.87304358
79Thyroiditis (HP:0100646)1.84866865
80Pancreatic fibrosis (HP:0100732)1.84639467
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.83864592
82Absent/shortened dynein arms (HP:0200106)1.83864592
83Supernumerary spleens (HP:0009799)1.83840325
84Growth hormone deficiency (HP:0000824)1.83779915
85Patchy hypopigmentation of hair (HP:0011365)1.83344949
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82972133
87White forelock (HP:0002211)1.82570671
88Supernumerary bones of the axial skeleton (HP:0009144)1.82312053
89Keratoconus (HP:0000563)1.82224851
90Increased corneal curvature (HP:0100692)1.82224851
91Intestinal atresia (HP:0011100)1.82074518
92Gastroesophageal reflux (HP:0002020)1.82045766
93Postaxial foot polydactyly (HP:0001830)1.81608345
94Absent eyebrow (HP:0002223)1.80818061
95Clubbing of toes (HP:0100760)1.80550237
96Hypothermia (HP:0002045)1.80457456
97Supernumerary ribs (HP:0005815)1.79802133
98Tented upper lip vermilion (HP:0010804)1.79800179
99Increased hepatocellular lipid droplets (HP:0006565)1.78909868
100Cupped ear (HP:0000378)1.77510278
101Reticulocytopenia (HP:0001896)1.76145369
102Aqueductal stenosis (HP:0002410)1.75504366
103Facial cleft (HP:0002006)1.75282770
104Abnormality of the renal medulla (HP:0100957)1.75150038
105Thyroid-stimulating hormone excess (HP:0002925)1.74952567
1063-Methylglutaconic aciduria (HP:0003535)1.74054662
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73878967
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73711527
109Abnormal hair whorl (HP:0010721)1.73634410
110Polydipsia (HP:0001959)1.73280076
111Abnormal drinking behavior (HP:0030082)1.73280076
112Pendular nystagmus (HP:0012043)1.73264892
113Epileptic encephalopathy (HP:0200134)1.72001878
114Methylmalonic aciduria (HP:0012120)1.71487911
115Abnormal respiratory motile cilium physiology (HP:0012261)1.70808153
116Astigmatism (HP:0000483)1.70024876
117Hepatocellular necrosis (HP:0001404)1.69689628
118Hepatic necrosis (HP:0002605)1.68377617
119Cerebral edema (HP:0002181)1.68304070
120Abnormal rod and cone electroretinograms (HP:0008323)1.68149457
121Anophthalmia (HP:0000528)1.68085888
122Gonadotropin excess (HP:0000837)1.68085466
123Pancreatic cysts (HP:0001737)1.67482651
124Abnormality of the incisor (HP:0000676)1.67236440
125Gait imbalance (HP:0002141)1.67020630
126Short thumb (HP:0009778)1.66812918
127Congenital stationary night blindness (HP:0007642)1.66638582
128Abnormality of the nasal septum (HP:0000419)1.66610034
129Congenital primary aphakia (HP:0007707)1.66447218
130Abnormality of the duodenum (HP:0002246)1.66271593
131Glycosuria (HP:0003076)1.65797820
132Abnormality of urine glucose concentration (HP:0011016)1.65797820
133Aganglionic megacolon (HP:0002251)1.65433195
134Hyperglycinuria (HP:0003108)1.65313471
135Congenital, generalized hypertrichosis (HP:0004540)1.65010488
136Abnormality of methionine metabolism (HP:0010901)1.64920673
137Abnormality of abdominal situs (HP:0011620)1.64571138
138Abdominal situs inversus (HP:0003363)1.64571138
139Median cleft lip (HP:0000161)1.63669479
140Tubular atrophy (HP:0000092)1.63641572
141Gaze-evoked nystagmus (HP:0000640)1.63316135
142Labial hypoplasia (HP:0000066)1.63076906
143Type II lissencephaly (HP:0007260)1.62470872
144Nephrogenic diabetes insipidus (HP:0009806)1.62199419
145Upper limb muscle weakness (HP:0003484)1.62182982
146Abnormality of glycine metabolism (HP:0010895)1.62094576
147Abnormality of serine family amino acid metabolism (HP:0010894)1.62094576
148Anencephaly (HP:0002323)1.61768428
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.61518766
150Widely spaced teeth (HP:0000687)1.61472546
151Horseshoe kidney (HP:0000085)1.60808309
152Glioma (HP:0009733)1.60774237
153Gastrointestinal atresia (HP:0002589)1.60300135
154Male pseudohermaphroditism (HP:0000037)1.60288388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.92564232
2WNK33.29990112
3FRK3.13638708
4SRPK12.79007295
5STK162.63989687
6CDC72.46959458
7NUAK12.37544923
8TAOK32.26073407
9MST42.23742020
10TRIM282.20787648
11BRSK22.16936771
12MKNK12.16433998
13MAP4K22.12075668
14PINK12.07507479
15ZAK2.01083100
16TNIK1.88742924
17TXK1.85368621
18BLK1.82777090
19YES11.82527850
20PLK21.81985179
21SIK31.81430712
22MKNK21.80680527
23PNCK1.71490599
24MAP2K71.56479977
25BMPR1B1.53805181
26EIF2AK21.51593751
27TAF11.50704854
28NEK11.45950851
29PLK41.43206140
30STK38L1.42851049
31BRD41.41074843
32BCR1.37421438
33WEE11.36007320
34ADRBK21.31524843
35MAPK131.29979402
36SIK21.28266824
37NME11.28064495
38GRK71.27626934
39BMPR21.25425054
40NTRK21.24582609
41NEK61.22981019
42MUSK1.21650054
43NLK1.20317782
44NTRK31.18166842
45TSSK61.16863615
46BUB11.16329239
47INSRR1.15837280
48TGFBR11.14541856
49ATR1.14382597
50ACVR1B1.14066850
51CDK71.11794952
52GRK11.06248164
53WNK41.03697836
54DYRK31.01928076
55CDK31.00992675
56FGFR20.96751350
57FGR0.94764082
58UHMK10.94090344
59CDK80.92221366
60PLK30.91978225
61MAP3K120.90368412
62CHEK20.90159359
63STK240.89618982
64CCNB10.89235184
65CDK190.88862480
66TTK0.84253293
67PLK10.82199078
68MAPKAPK50.81550975
69VRK20.81431202
70PBK0.80685162
71CLK10.80212919
72AKT30.79102129
73OXSR10.78944568
74PKN10.77089501
75MAP3K60.75680312
76MAP3K40.75125021
77STK40.74934241
78PRPF4B0.74887441
79VRK10.72382408
80CSNK1G20.70195777
81PAK30.69146401
82STK390.68043272
83ERBB30.65952095
84PASK0.65690096
85DYRK1A0.64702873
86ATM0.62748353
87SGK20.62568725
88RPS6KA50.61441231
89CHEK10.60966672
90CDK10.57594234
91RPS6KA40.57567984
92CSNK1G10.57085197
93EPHA40.56721670
94STK30.55774845
95PRKCQ0.55216744
96ROCK20.54030250
97FES0.53398464
98BCKDK0.53110827
99DYRK20.52699869
100CDK120.52650771
101CAMK2A0.52214520
102TLK10.52176113
103EIF2AK30.51298338
104CSNK1G30.50752123
105TNK20.50696615
106PRKCG0.50431534
107LYN0.49382346
108CAMKK20.48010156
109CSNK2A20.47373868
110PRKCE0.46335970
111ADRBK10.46259313
112CAMK2B0.46111452
113CDK20.45843127
114TEC0.45464954
115BRSK10.45345418
116CDK90.45238948
117SGK4940.45020279
118SGK2230.45020279
119NEK20.44849630
120SGK10.44797695
121AURKB0.44137012
122CSNK1A1L0.41397911
123IRAK40.40691070
124CSNK1E0.40500518
125FLT30.39914821
126GRK60.39231127
127EIF2AK10.37004455
128AKT20.36677422
129MAPK140.36643842
130RPS6KB10.36513269
131CSNK2A10.33775753
132PRKACB0.31995963
133TIE10.30177191
134FGFR10.26637765
135ERBB40.25959623
136DYRK1B0.25911175
137CSNK1A10.25489297
138PRKDC0.24191353
139MAPK150.21746838

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25758058
2Mismatch repair_Homo sapiens_hsa034302.70208844
3Fanconi anemia pathway_Homo sapiens_hsa034602.66849730
4Homologous recombination_Homo sapiens_hsa034402.61295450
5Nicotine addiction_Homo sapiens_hsa050332.52095730
6DNA replication_Homo sapiens_hsa030302.51323677
7Non-homologous end-joining_Homo sapiens_hsa034502.46493653
8RNA polymerase_Homo sapiens_hsa030202.42055801
9Propanoate metabolism_Homo sapiens_hsa006402.34683565
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20704535
11Spliceosome_Homo sapiens_hsa030402.20246033
12Selenocompound metabolism_Homo sapiens_hsa004502.09977418
13Butanoate metabolism_Homo sapiens_hsa006502.08642707
14Nucleotide excision repair_Homo sapiens_hsa034202.00036873
15Basal transcription factors_Homo sapiens_hsa030221.98362060
16Base excision repair_Homo sapiens_hsa034101.95396135
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.88214236
18Phototransduction_Homo sapiens_hsa047441.87558644
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79169376
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73271937
21Cell cycle_Homo sapiens_hsa041101.70889443
22RNA degradation_Homo sapiens_hsa030181.62366899
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52281439
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51351556
25mRNA surveillance pathway_Homo sapiens_hsa030151.50325685
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49064290
27Oxidative phosphorylation_Homo sapiens_hsa001901.47792103
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42584257
29Serotonergic synapse_Homo sapiens_hsa047261.40703528
30RNA transport_Homo sapiens_hsa030131.36102815
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35624901
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.32819349
33Taste transduction_Homo sapiens_hsa047421.27848532
34Pyrimidine metabolism_Homo sapiens_hsa002401.25255882
35Tryptophan metabolism_Homo sapiens_hsa003801.24842526
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24488661
37Circadian rhythm_Homo sapiens_hsa047101.23748760
38Basal cell carcinoma_Homo sapiens_hsa052171.21584997
39Glutamatergic synapse_Homo sapiens_hsa047241.21157381
40Peroxisome_Homo sapiens_hsa041461.21028677
41Nitrogen metabolism_Homo sapiens_hsa009101.19458767
42Parkinsons disease_Homo sapiens_hsa050121.18721013
43Morphine addiction_Homo sapiens_hsa050321.18573946
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.17684524
45Hedgehog signaling pathway_Homo sapiens_hsa043401.16951198
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16777518
47Steroid biosynthesis_Homo sapiens_hsa001001.12754353
48Ribosome_Homo sapiens_hsa030101.11375585
49Huntingtons disease_Homo sapiens_hsa050161.08495578
50Axon guidance_Homo sapiens_hsa043601.07112450
51Purine metabolism_Homo sapiens_hsa002301.05119613
52Alzheimers disease_Homo sapiens_hsa050101.04169190
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03095558
54Fatty acid degradation_Homo sapiens_hsa000711.02541427
55Proteasome_Homo sapiens_hsa030500.98652222
56Wnt signaling pathway_Homo sapiens_hsa043100.95139940
57Autoimmune thyroid disease_Homo sapiens_hsa053200.94616040
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93824052
59Long-term depression_Homo sapiens_hsa047300.93316186
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91844805
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91168254
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90933073
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88710903
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88683024
65Primary immunodeficiency_Homo sapiens_hsa053400.88441482
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86885916
67Oocyte meiosis_Homo sapiens_hsa041140.86231156
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84875089
69GABAergic synapse_Homo sapiens_hsa047270.84464645
70Fatty acid elongation_Homo sapiens_hsa000620.82458706
71Calcium signaling pathway_Homo sapiens_hsa040200.81930645
72Fatty acid metabolism_Homo sapiens_hsa012120.81888271
73Caffeine metabolism_Homo sapiens_hsa002320.80631616
74Ether lipid metabolism_Homo sapiens_hsa005650.80339005
75Collecting duct acid secretion_Homo sapiens_hsa049660.79715917
76Circadian entrainment_Homo sapiens_hsa047130.79382812
77Cardiac muscle contraction_Homo sapiens_hsa042600.78757879
78Sphingolipid metabolism_Homo sapiens_hsa006000.76926086
79Retinol metabolism_Homo sapiens_hsa008300.76433694
80Linoleic acid metabolism_Homo sapiens_hsa005910.76013210
81Regulation of autophagy_Homo sapiens_hsa041400.75290880
82Epstein-Barr virus infection_Homo sapiens_hsa051690.74617696
83Pyruvate metabolism_Homo sapiens_hsa006200.72987388
84Dopaminergic synapse_Homo sapiens_hsa047280.71697442
85Olfactory transduction_Homo sapiens_hsa047400.71519360
86TGF-beta signaling pathway_Homo sapiens_hsa043500.71435209
87Long-term potentiation_Homo sapiens_hsa047200.71109264
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.70616338
89Allograft rejection_Homo sapiens_hsa053300.70223209
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69857822
91Amphetamine addiction_Homo sapiens_hsa050310.69525498
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68993479
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.68518103
94beta-Alanine metabolism_Homo sapiens_hsa004100.68259942
95Metabolic pathways_Homo sapiens_hsa011000.65754018
96Chemical carcinogenesis_Homo sapiens_hsa052040.64545720
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64314556
98Melanogenesis_Homo sapiens_hsa049160.63775199
99Protein export_Homo sapiens_hsa030600.63566394
100Folate biosynthesis_Homo sapiens_hsa007900.60418485
101Asthma_Homo sapiens_hsa053100.60151615
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59633043
103Hematopoietic cell lineage_Homo sapiens_hsa046400.59429958
104Vitamin B6 metabolism_Homo sapiens_hsa007500.57407964
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56648528
106Herpes simplex infection_Homo sapiens_hsa051680.54414916
107Renin secretion_Homo sapiens_hsa049240.52539949
108p53 signaling pathway_Homo sapiens_hsa041150.52431881
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51958441
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.51593796
111One carbon pool by folate_Homo sapiens_hsa006700.51561841
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51518549
113Alcoholism_Homo sapiens_hsa050340.51373876
114Dorso-ventral axis formation_Homo sapiens_hsa043200.51169359
115Graft-versus-host disease_Homo sapiens_hsa053320.51005586
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50938420
117Vitamin digestion and absorption_Homo sapiens_hsa049770.50433885
118Glutathione metabolism_Homo sapiens_hsa004800.50007836
119MAPK signaling pathway_Homo sapiens_hsa040100.49973599
120Pathways in cancer_Homo sapiens_hsa052000.49908885
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49337164
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46849366
123MicroRNAs in cancer_Homo sapiens_hsa052060.46762334
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45136640
125Rheumatoid arthritis_Homo sapiens_hsa053230.44427144
126Salivary secretion_Homo sapiens_hsa049700.44288735
127Viral carcinogenesis_Homo sapiens_hsa052030.44049699
128Ras signaling pathway_Homo sapiens_hsa040140.43392483
129ErbB signaling pathway_Homo sapiens_hsa040120.42570442
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42262501
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42172349
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42117751
133Hippo signaling pathway_Homo sapiens_hsa043900.41970015
134T cell receptor signaling pathway_Homo sapiens_hsa046600.41867186
135HTLV-I infection_Homo sapiens_hsa051660.41350865
136Melanoma_Homo sapiens_hsa052180.41044462
137Notch signaling pathway_Homo sapiens_hsa043300.39950337
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38710789
139Oxytocin signaling pathway_Homo sapiens_hsa049210.38633758
140African trypanosomiasis_Homo sapiens_hsa051430.38451959
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38331886
142Cocaine addiction_Homo sapiens_hsa050300.37707099
143Measles_Homo sapiens_hsa051620.37642248
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23326398
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23185638
146Lysine degradation_Homo sapiens_hsa003100.17605714

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