METTL15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heparin biosynthetic process (GO:0030210)4.73025001
2heparin metabolic process (GO:0030202)4.73025001
3meiotic chromosome segregation (GO:0045132)4.55851709
4CENP-A containing nucleosome assembly (GO:0034080)4.33190083
5DNA double-strand break processing (GO:0000729)4.13616532
6DNA strand elongation involved in DNA replication (GO:0006271)4.09530954
7kinetochore organization (GO:0051383)4.06519900
8telomere maintenance via semi-conservative replication (GO:0032201)3.97033890
9DNA strand elongation (GO:0022616)3.94679927
10centriole assembly (GO:0098534)3.83453200
11chromatin remodeling at centromere (GO:0031055)3.82697617
12DNA replication initiation (GO:0006270)3.81241914
13detection of light stimulus involved in sensory perception (GO:0050962)3.76098866
14detection of light stimulus involved in visual perception (GO:0050908)3.76098866
15pseudouridine synthesis (GO:0001522)3.75923420
16fucose catabolic process (GO:0019317)3.72340359
17L-fucose metabolic process (GO:0042354)3.72340359
18L-fucose catabolic process (GO:0042355)3.72340359
19kinetochore assembly (GO:0051382)3.71720119
20protein deneddylation (GO:0000338)3.68816805
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.66466727
22NADH dehydrogenase complex assembly (GO:0010257)3.66466727
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66466727
24protein complex biogenesis (GO:0070271)3.64464327
25attachment of spindle microtubules to kinetochore (GO:0008608)3.53566389
26cullin deneddylation (GO:0010388)3.52827072
27mitochondrial respiratory chain complex assembly (GO:0033108)3.49526404
28RNA-dependent DNA replication (GO:0006278)3.47102532
29response to pheromone (GO:0019236)3.39536965
30telomere maintenance via recombination (GO:0000722)3.39264625
31telomere maintenance via telomere lengthening (GO:0010833)3.39050660
32regulation of memory T cell differentiation (GO:0043380)3.36670083
33resolution of meiotic recombination intermediates (GO:0000712)3.35964119
34histone-serine phosphorylation (GO:0035404)3.35073058
35neural tube formation (GO:0001841)3.34820196
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33990792
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33974331
38positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.32973532
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30313219
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30313219
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28132608
42reciprocal DNA recombination (GO:0035825)3.27926139
43reciprocal meiotic recombination (GO:0007131)3.27926139
44mitotic metaphase plate congression (GO:0007080)3.27807443
45DNA replication-independent nucleosome assembly (GO:0006336)3.26945686
46DNA replication-independent nucleosome organization (GO:0034724)3.26945686
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26075182
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.26049377
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26049377
50negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26049377
51negative regulation of sister chromatid segregation (GO:0033046)3.26049377
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24760498
53mitotic recombination (GO:0006312)3.23262229
54spindle assembly checkpoint (GO:0071173)3.22800343
55metaphase plate congression (GO:0051310)3.20590476
56mitotic spindle assembly checkpoint (GO:0007094)3.19450107
57L-serine metabolic process (GO:0006563)3.16460839
58protein K6-linked ubiquitination (GO:0085020)3.14076580
59mitotic chromosome condensation (GO:0007076)3.13722803
60negative regulation of chromosome segregation (GO:0051985)3.13351451
61mitotic sister chromatid segregation (GO:0000070)3.11614602
62platelet dense granule organization (GO:0060155)3.10980378
63respiratory chain complex IV assembly (GO:0008535)3.10298126
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09217074
65proteasome assembly (GO:0043248)3.07759885
66synapsis (GO:0007129)3.03933000
67water-soluble vitamin biosynthetic process (GO:0042364)3.01695371
68histone exchange (GO:0043486)3.01176218
69negative regulation of ligase activity (GO:0051352)3.01122278
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01122278
71replication fork processing (GO:0031297)3.00597187
72cytochrome complex assembly (GO:0017004)2.99544179
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99427144
74organic cation transport (GO:0015695)2.95656675
75C4-dicarboxylate transport (GO:0015740)2.95085740
76spindle checkpoint (GO:0031577)2.94703433
77recombinational repair (GO:0000725)2.93633897
78establishment of chromosome localization (GO:0051303)2.93499528
79double-strand break repair via homologous recombination (GO:0000724)2.92763037
80mitotic spindle checkpoint (GO:0071174)2.92551774
81behavioral response to nicotine (GO:0035095)2.92451720
82regulation of DNA endoreduplication (GO:0032875)2.91550136
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90901081
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90901081
85mitochondrial DNA replication (GO:0006264)2.90876413
86branched-chain amino acid catabolic process (GO:0009083)2.90219904
87indole-containing compound catabolic process (GO:0042436)2.89363366
88indolalkylamine catabolic process (GO:0046218)2.89363366
89tryptophan catabolic process (GO:0006569)2.89363366
90telomere maintenance (GO:0000723)2.89181296
91telomere organization (GO:0032200)2.89125491
92mannosylation (GO:0097502)2.89027769
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.88901881
94DNA unwinding involved in DNA replication (GO:0006268)2.88164969
95epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87220581
96kynurenine metabolic process (GO:0070189)2.86839536
97positive regulation of receptor biosynthetic process (GO:0010870)2.86821460
98histone H2A acetylation (GO:0043968)2.86624246
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86526188
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86526188
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86526188
102cellular ketone body metabolic process (GO:0046950)2.86502660
103regulation of mitochondrial translation (GO:0070129)2.85970670
104protein K11-linked deubiquitination (GO:0035871)2.85821682
105ribosomal small subunit assembly (GO:0000028)2.84961668
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.82704654
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82404593
108photoreceptor cell maintenance (GO:0045494)2.82371928
109DNA deamination (GO:0045006)2.82323022
110amino acid salvage (GO:0043102)2.82155538
111L-methionine salvage (GO:0071267)2.82155538
112L-methionine biosynthetic process (GO:0071265)2.82155538
113negative regulation of multicellular organism growth (GO:0040015)2.80581394
114regulation of glucokinase activity (GO:0033131)2.79652972
115regulation of hexokinase activity (GO:1903299)2.79652972
116IMP biosynthetic process (GO:0006188)2.79009353
117epithelial cilium movement (GO:0003351)2.78061730
118spliceosomal complex assembly (GO:0000245)2.77470516
119magnesium ion transport (GO:0015693)2.77363135
120mitotic sister chromatid cohesion (GO:0007064)2.76770162
121DNA ligation (GO:0006266)2.76430159
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76305232
123sister chromatid segregation (GO:0000819)2.74639558
124negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74417912
125negative regulation of translation, ncRNA-mediated (GO:0040033)2.74417912
126regulation of translation, ncRNA-mediated (GO:0045974)2.74417912
127protein-cofactor linkage (GO:0018065)2.74208422
128negative regulation of mitosis (GO:0045839)2.73982357
129regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73848600
130interleukin-1-mediated signaling pathway (GO:0070498)2.73567341
131signal peptide processing (GO:0006465)2.73520121
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.72974562
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72508846
134nonmotile primary cilium assembly (GO:0035058)2.72183068
135regulation of cellular amino acid metabolic process (GO:0006521)2.72070436
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71854037
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.71854037
138daunorubicin metabolic process (GO:0044597)2.71437007
139polyketide metabolic process (GO:0030638)2.71437007
140doxorubicin metabolic process (GO:0044598)2.71437007
141RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70105018
142CTP metabolic process (GO:0046036)2.69750515
143CTP biosynthetic process (GO:0006241)2.69750515
144cilium or flagellum-dependent cell motility (GO:0001539)2.69462515
145intraciliary transport (GO:0042073)2.69299185
146detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.69273553
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69035648
148nucleobase biosynthetic process (GO:0046112)2.68540192
149maturation of 5.8S rRNA (GO:0000460)2.68348124
150cAMP catabolic process (GO:0006198)2.67257293
151regulation of meiosis I (GO:0060631)2.67132545
152piRNA metabolic process (GO:0034587)2.66211964
153cilium organization (GO:0044782)2.65811517
154regulation of cilium movement (GO:0003352)2.65742245
155negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64234709
156peptidyl-histidine modification (GO:0018202)2.63892031
157rRNA catabolic process (GO:0016075)2.62446900
158prenylation (GO:0097354)2.60994082
159protein prenylation (GO:0018342)2.60994082
160cyclic nucleotide catabolic process (GO:0009214)2.60598416
161indolalkylamine metabolic process (GO:0006586)2.60328585
162somite rostral/caudal axis specification (GO:0032525)2.60276827
163regulation of hippo signaling (GO:0035330)2.60151139
164regulation of acyl-CoA biosynthetic process (GO:0050812)2.59720224
165positive regulation of meiosis (GO:0045836)2.58337972
166cilium assembly (GO:0042384)2.57775177
167ketone body metabolic process (GO:1902224)2.56468484
168preassembly of GPI anchor in ER membrane (GO:0016254)2.55778439
169cilium movement (GO:0003341)2.55474219
170acrosome assembly (GO:0001675)2.54818877
171cilium morphogenesis (GO:0060271)2.54359991
172estrogen biosynthetic process (GO:0006703)2.53871463
173retinal cone cell development (GO:0046549)2.49697298
174establishment of protein localization to mitochondrial membrane (GO:0090151)2.48003517
175somatic hypermutation of immunoglobulin genes (GO:0016446)2.47561198
176somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47561198
177nephron tubule morphogenesis (GO:0072078)2.45021458
178nephron epithelium morphogenesis (GO:0072088)2.45021458
179tryptophan metabolic process (GO:0006568)2.44523960
180sulfation (GO:0051923)2.44419301
181response to X-ray (GO:0010165)2.44338482
182positive regulation of meiotic cell cycle (GO:0051446)2.42925105
183axoneme assembly (GO:0035082)2.39350312
184regulation of nuclear cell cycle DNA replication (GO:0033262)2.37109271
185sperm motility (GO:0030317)2.36369274
186regulation of action potential (GO:0098900)2.35108386
187GPI anchor metabolic process (GO:0006505)2.33403987
188establishment of protein localization to Golgi (GO:0072600)2.33267891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.16780250
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.62003988
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.80200652
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32780206
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.20376628
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.20012978
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.19925785
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04817265
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99143991
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.98507221
11GBX2_23144817_ChIP-Seq_PC3_Human2.93176966
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92401885
13IGF1R_20145208_ChIP-Seq_DFB_Human2.87977251
14ZNF274_21170338_ChIP-Seq_K562_Hela2.87080012
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82789170
16AR_21909140_ChIP-Seq_LNCAP_Human2.78665421
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77840920
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71413787
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68111192
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60013347
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.52780326
22* FOXM1_23109430_ChIP-Seq_U2OS_Human2.48845587
23FOXP3_21729870_ChIP-Seq_TREG_Human2.43927293
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41045469
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35557654
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35211079
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35110032
28HOXB4_20404135_ChIP-ChIP_EML_Mouse2.28284122
29VDR_23849224_ChIP-Seq_CD4+_Human2.27524349
30ELK1_19687146_ChIP-ChIP_HELA_Human2.27506059
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25116839
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23915024
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.23418626
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.20308386
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16690864
36* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15710060
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14147900
38P300_19829295_ChIP-Seq_ESCs_Human2.09186858
39MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02191236
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00736906
41NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00498739
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93616267
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92171486
44ER_23166858_ChIP-Seq_MCF-7_Human1.89777750
45EZH2_22144423_ChIP-Seq_EOC_Human1.88435126
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85561368
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82939524
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82846008
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81648106
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81446710
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76998395
52DCP1A_22483619_ChIP-Seq_HELA_Human1.76538914
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71379177
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71025596
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69525119
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.65738499
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63371443
58SMAD4_21799915_ChIP-Seq_A2780_Human1.62486888
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61667958
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.59370643
61STAT3_23295773_ChIP-Seq_U87_Human1.59085450
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59067540
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58932452
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57255017
65CBP_20019798_ChIP-Seq_JUKART_Human1.57083371
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57083371
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55212732
68BCAT_22108803_ChIP-Seq_LS180_Human1.53626445
69IRF1_19129219_ChIP-ChIP_H3396_Human1.50474467
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.49543176
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48955839
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48443236
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46868170
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46342352
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46192914
76MYC_18940864_ChIP-ChIP_HL60_Human1.44522869
77GABP_19822575_ChIP-Seq_HepG2_Human1.42989166
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42499052
79TCF4_23295773_ChIP-Seq_U87_Human1.41981941
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39100670
81XRN2_22483619_ChIP-Seq_HELA_Human1.38887506
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37509531
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36474416
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36162045
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35578646
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.35399407
87AR_25329375_ChIP-Seq_VCAP_Human1.34774821
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.33998847
89TCF4_22108803_ChIP-Seq_LS180_Human1.33975734
90TP53_22573176_ChIP-Seq_HFKS_Human1.33920145
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33536228
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33406126
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33371105
94FUS_26573619_Chip-Seq_HEK293_Human1.33197173
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31227326
96SOX2_19829295_ChIP-Seq_ESCs_Human1.29871987
97NANOG_19829295_ChIP-Seq_ESCs_Human1.29871987
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.29500863
99CDX2_22108803_ChIP-Seq_LS180_Human1.27931284
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24180330
101TTF2_22483619_ChIP-Seq_HELA_Human1.22658228
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22479550
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22193948
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22005101
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21996163
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.21881976
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21448718
108GATA1_22025678_ChIP-Seq_K562_Human1.21042488
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.20757591
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19911853
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19729994
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18497651
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.18033161
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17262428
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.17026151
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.16887316
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15888521
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15876076
119P53_22387025_ChIP-Seq_ESCs_Mouse1.15762436
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14559921
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14542795
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13574087
123RUNX2_22187159_ChIP-Seq_PCA_Human1.12968248
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12317330
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09819213
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.06873061
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05672149
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04423657
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.04423657
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04253424
131POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03763248
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.03253148
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02597842
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02489785
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02465982
136PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01875494
137P300_18555785_Chip-Seq_ESCs_Mouse1.01773552
138TAF15_26573619_Chip-Seq_HEK293_Human1.01669250
139EWS_26573619_Chip-Seq_HEK293_Human1.00854204
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00702504
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00570419
142OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00069135
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.99357227
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99022084
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98966163
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98966163
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.98791298
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96796281
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95508494
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.94474382
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94088354
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92811766
153SPI1_23547873_ChIP-Seq_NB4_Human0.90405236
154POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87691142
155MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86319489
156CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85436061
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.84149186
158VDR_22108803_ChIP-Seq_LS180_Human0.81528447
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81138773
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80960025
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80925788
162RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79860878
163EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78905383
164CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75684328
165KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75025594
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.74650547
167PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74350953
168TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73728456
169NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72742061
170PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72413068
171CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69814339
172PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68951187
173CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.68773013
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.67978966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.04596301
2MP0010094_abnormal_chromosome_stability3.57641016
3MP0002396_abnormal_hematopoietic_system3.42226655
4MP0001188_hyperpigmentation3.29776487
5MP0009379_abnormal_foot_pigmentation3.22816744
6MP0006054_spinal_hemorrhage3.16737887
7MP0003806_abnormal_nucleotide_metabolis3.09034309
8MP0003693_abnormal_embryo_hatching2.78022996
9MP0003077_abnormal_cell_cycle2.73045416
10MP0002160_abnormal_reproductive_system2.60799374
11MP0005075_abnormal_melanosome_morpholog2.53516198
12MP0003950_abnormal_plasma_membrane2.49344155
13MP0003763_abnormal_thymus_physiology2.38805894
14MP0008007_abnormal_cellular_replicative2.37763825
15MP0006072_abnormal_retinal_apoptosis2.37468927
16MP0001986_abnormal_taste_sensitivity2.37164220
17MP0003195_calcinosis2.35024579
18MP0005551_abnormal_eye_electrophysiolog2.33272007
19MP0003111_abnormal_nucleus_morphology2.26343572
20MP0000569_abnormal_digit_pigmentation2.21551539
21MP0004957_abnormal_blastocyst_morpholog2.21345778
22MP0005646_abnormal_pituitary_gland2.17660160
23MP0002095_abnormal_skin_pigmentation2.16761466
24MP0000015_abnormal_ear_pigmentation2.15131071
25MP0000427_abnormal_hair_cycle2.13711964
26MP0003718_maternal_effect1.98801008
27MP0005174_abnormal_tail_pigmentation1.94458559
28MP0005253_abnormal_eye_physiology1.93489138
29MP0003191_abnormal_cellular_cholesterol1.92455765
30MP0008932_abnormal_embryonic_tissue1.89847226
31MP0008058_abnormal_DNA_repair1.87560232
32MP0003252_abnormal_bile_duct1.86948799
33MP0008877_abnormal_DNA_methylation1.85552911
34MP0008057_abnormal_DNA_replication1.83923532
35MP0003646_muscle_fatigue1.83443076
36MP0006036_abnormal_mitochondrial_physio1.82065867
37MP0000566_synostosis1.81028980
38MP0004134_abnormal_chest_morphology1.77831445
39MP0005389_reproductive_system_phenotype1.76761393
40MP0005397_hematopoietic_system_phenotyp1.73232841
41MP0001545_abnormal_hematopoietic_system1.73232841
42MP0009697_abnormal_copulation1.72509239
43MP0004782_abnormal_surfactant_physiolog1.70699689
44MP0002938_white_spotting1.69575292
45MP0004808_abnormal_hematopoietic_stem1.68852010
46MP0002234_abnormal_pharynx_morphology1.64390394
47MP0002102_abnormal_ear_morphology1.63957557
48MP0005671_abnormal_response_to1.63911110
49MP0000678_abnormal_parathyroid_gland1.58286882
50MP0001835_abnormal_antigen_presentation1.57024321
51MP0000490_abnormal_crypts_of1.56680638
52MP0005171_absent_coat_pigmentation1.56483915
53MP0006292_abnormal_olfactory_placode1.55806017
54MP0001764_abnormal_homeostasis1.55306726
55MP0002132_abnormal_respiratory_system1.55157022
56MP0002163_abnormal_gland_morphology1.47221230
57MP0003890_abnormal_embryonic-extraembry1.46241453
58MP0008775_abnormal_heart_ventricle1.45024542
59MP0003880_abnormal_central_pattern1.44229356
60MP0003011_delayed_dark_adaptation1.43002374
61MP0001853_heart_inflammation1.40533438
62MP0005408_hypopigmentation1.39528877
63MP0006276_abnormal_autonomic_nervous1.37053586
64MP0005084_abnormal_gallbladder_morpholo1.33718148
65MP0005379_endocrine/exocrine_gland_phen1.33527789
66MP0004215_abnormal_myocardial_fiber1.32596636
67MP0003941_abnormal_skin_development1.30010237
68MP0000465_gastrointestinal_hemorrhage1.28368061
69MP0001968_abnormal_touch/_nociception1.26375206
70MP0002736_abnormal_nociception_after1.24209986
71MP0001293_anophthalmia1.23494585
72MP0008872_abnormal_physiological_respon1.23354242
73MP0003656_abnormal_erythrocyte_physiolo1.22823473
74MP0003937_abnormal_limbs/digits/tail_de1.22721358
75MP0000372_irregular_coat_pigmentation1.22144517
76MP0002876_abnormal_thyroid_physiology1.19218904
77MP0005410_abnormal_fertilization1.19073307
78MP0005085_abnormal_gallbladder_physiolo1.18518041
79MP0002398_abnormal_bone_marrow1.17300432
80MP0001485_abnormal_pinna_reflex1.14763358
81MP0009046_muscle_twitch1.14009546
82MP0004145_abnormal_muscle_electrophysio1.10591380
83MP0004381_abnormal_hair_follicle1.09643805
84MP0006035_abnormal_mitochondrial_morpho1.09051938
85MP0000631_abnormal_neuroendocrine_gland1.06648077
86MP0001119_abnormal_female_reproductive1.05941387
87MP0003567_abnormal_fetal_cardiomyocyte1.04993843
88MP0001929_abnormal_gametogenesis1.04518899
89MP0005187_abnormal_penis_morphology1.03877370
90MP0003186_abnormal_redox_activity1.03576421
91MP0000647_abnormal_sebaceous_gland1.03021654
92MP0000689_abnormal_spleen_morphology1.02768246
93MP0001919_abnormal_reproductive_system1.01543365
94MP0000703_abnormal_thymus_morphology0.99813336
95MP0001324_abnormal_eye_pigmentation0.98307290
96MP0003943_abnormal_hepatobiliary_system0.97161368
97MP0001529_abnormal_vocalization0.97048245
98MP0002090_abnormal_vision0.96912278
99MP0003119_abnormal_digestive_system0.96762079
100MP0005195_abnormal_posterior_eye0.96492508
101MP0009745_abnormal_behavioral_response0.96476354
102MP0004142_abnormal_muscle_tone0.95024776
103MP0001145_abnormal_male_reproductive0.94268456
104MP0003698_abnormal_male_reproductive0.94178037
105MP0005360_urolithiasis0.93181612
106MP0000371_diluted_coat_color0.93160891
107MP0001486_abnormal_startle_reflex0.92847408
108MP0002722_abnormal_immune_system0.92543243
109MP0000681_abnormal_thyroid_gland0.91970004
110MP0005083_abnormal_biliary_tract0.91837037
111MP0004084_abnormal_cardiac_muscle0.90899607
112MP0000383_abnormal_hair_follicle0.90804523
113MP0002837_dystrophic_cardiac_calcinosis0.89821271
114MP0005409_darkened_coat_color0.89720394
115MP0004133_heterotaxia0.88935276
116MP0005645_abnormal_hypothalamus_physiol0.88050099
117MP0005391_vision/eye_phenotype0.88037212
118MP0002557_abnormal_social/conspecific_i0.87438279
119MP0001800_abnormal_humoral_immune0.86970085
120MP0000716_abnormal_immune_system0.86381653
121MP0004885_abnormal_endolymph0.85839112
122MP0002429_abnormal_blood_cell0.84418011
123MP0002420_abnormal_adaptive_immunity0.83986230
124MP0002272_abnormal_nervous_system0.83720492
125MP0001905_abnormal_dopamine_level0.83668941
126MP0005332_abnormal_amino_acid0.83377323
127MP0009333_abnormal_splenocyte_physiolog0.82632390
128MP0001984_abnormal_olfaction0.82616399
129MP0005395_other_phenotype0.82299917
130MP0003786_premature_aging0.82138034
131MP0002019_abnormal_tumor_incidence0.80727780
132MP0004085_abnormal_heartbeat0.80186348
133MP0000350_abnormal_cell_proliferation0.80138213
134MP0001819_abnormal_immune_cell0.80027744
135MP0004484_altered_response_of0.79448461
136MP0002210_abnormal_sex_determination0.78310927
137MP0002752_abnormal_somatic_nervous0.78057254
138MP0002638_abnormal_pupillary_reflex0.78011884
139MP0003755_abnormal_palate_morphology0.77814752
140MP0001299_abnormal_eye_distance/0.76685562
141MP0004043_abnormal_pH_regulation0.76485222
142MP0002723_abnormal_immune_serum0.74427502
143MP0003787_abnormal_imprinting0.74375461
144MP0001286_abnormal_eye_development0.74315369
145MP0002452_abnormal_antigen_presenting0.74141458
146MP0010307_abnormal_tumor_latency0.73976762
147MP0009785_altered_susceptibility_to0.73517009
148MP0005636_abnormal_mineral_homeostasis0.72497591
149MP0009780_abnormal_chondrocyte_physiolo0.72145698
150MP0003221_abnormal_cardiomyocyte_apopto0.71597199
151MP0002928_abnormal_bile_duct0.71456263
152MP0002233_abnormal_nose_morphology0.71317872
153MP0008875_abnormal_xenobiotic_pharmacok0.68235598
154MP0000313_abnormal_cell_death0.68006582
155MP0005025_abnormal_response_to0.67610258
156MP0001664_abnormal_digestion0.63534562
157MP0003136_yellow_coat_color0.63528693
158MP0000653_abnormal_sex_gland0.62648823
159MP0001915_intracranial_hemorrhage0.61821858

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)5.27215334
2Aplasia/Hypoplasia of the fovea (HP:0008060)5.27215334
3Congenital stationary night blindness (HP:0007642)4.32784051
4Abnormality of the fovea (HP:0000493)4.14206404
5Generalized aminoaciduria (HP:0002909)3.71655952
6Hepatic necrosis (HP:0002605)3.50886542
7Volvulus (HP:0002580)3.48196062
8Type I transferrin isoform profile (HP:0003642)3.40366081
9Renal cortical cysts (HP:0000803)3.31604060
10Aplasia/Hypoplasia of the macula (HP:0008059)3.25212390
11Mitochondrial inheritance (HP:0001427)3.23053921
12Aplastic anemia (HP:0001915)3.21949738
13Abnormal rod and cone electroretinograms (HP:0008323)3.18474230
14True hermaphroditism (HP:0010459)3.18208988
15Hepatocellular necrosis (HP:0001404)3.17667857
16Central scotoma (HP:0000603)3.14769526
17Patchy hypopigmentation of hair (HP:0011365)3.14402772
18Abnormality of macular pigmentation (HP:0008002)3.09298592
19Nephronophthisis (HP:0000090)3.04036654
20Respiratory difficulties (HP:0002880)3.03285842
21Birth length less than 3rd percentile (HP:0003561)2.98621525
22Increased CSF lactate (HP:0002490)2.97197648
23Aplasia/Hypoplasia affecting the retina (HP:0008061)2.96244756
24Acute necrotizing encephalopathy (HP:0006965)2.93278003
25Medial flaring of the eyebrow (HP:0010747)2.91541838
26Occipital encephalocele (HP:0002085)2.89505433
27Increased serum lactate (HP:0002151)2.85393427
28Albinism (HP:0001022)2.84783862
29Nausea (HP:0002018)2.83204336
30Abnormality of the anterior horn cell (HP:0006802)2.82530278
31Degeneration of anterior horn cells (HP:0002398)2.82530278
32Self-mutilation (HP:0000742)2.81414615
33Severe visual impairment (HP:0001141)2.79649800
34Abnormal number of erythroid precursors (HP:0012131)2.77105036
35Pancreatic fibrosis (HP:0100732)2.75461344
36Bilateral microphthalmos (HP:0007633)2.73945051
37Abnormality of cells of the erythroid lineage (HP:0012130)2.73554242
38Abnormal hair whorl (HP:0010721)2.70027873
39Abnormal mitochondria in muscle tissue (HP:0008316)2.65827602
40Abnormality of the renal medulla (HP:0100957)2.64544571
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63722409
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.58030240
43Progressive inability to walk (HP:0002505)2.53088678
44Reduced antithrombin III activity (HP:0001976)2.52914978
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49627596
46Abnormal protein N-linked glycosylation (HP:0012347)2.49627596
47Abnormal protein glycosylation (HP:0012346)2.49627596
48Abnormal glycosylation (HP:0012345)2.49627596
49Large for gestational age (HP:0001520)2.48567614
50Pancreatic cysts (HP:0001737)2.48466115
51Inability to walk (HP:0002540)2.47407043
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46897771
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46897771
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46824756
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.42344480
56Chronic hepatic failure (HP:0100626)2.41070201
57Abnormality of fatty-acid metabolism (HP:0004359)2.39125508
58Abnormality of chromosome stability (HP:0003220)2.37951964
59Poor head control (HP:0002421)2.36988234
60Progressive macrocephaly (HP:0004481)2.36340210
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.35629594
62Abnormality of the renal cortex (HP:0011035)2.33254518
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32743833
64Abnormality of alanine metabolism (HP:0010916)2.32743833
65Hyperalaninemia (HP:0003348)2.32743833
66Attenuation of retinal blood vessels (HP:0007843)2.32168258
67Hyperglycinuria (HP:0003108)2.30840365
68Reticulocytopenia (HP:0001896)2.30688961
69Acute encephalopathy (HP:0006846)2.30642413
70Methylmalonic acidemia (HP:0002912)2.29876172
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29790696
72Nephrogenic diabetes insipidus (HP:0009806)2.29108490
73Tubulointerstitial nephritis (HP:0001970)2.28820634
74Pendular nystagmus (HP:0012043)2.28211961
75Dynein arm defect of respiratory motile cilia (HP:0012255)2.26938983
76Absent/shortened dynein arms (HP:0200106)2.26938983
77Colon cancer (HP:0003003)2.25575198
78Gaze-evoked nystagmus (HP:0000640)2.25225573
79Congenital primary aphakia (HP:0007707)2.25057371
80Abnormality of lateral ventricle (HP:0030047)2.21344158
81Genital tract atresia (HP:0001827)2.19507439
82Fair hair (HP:0002286)2.17558300
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16465197
84Hyperglycinemia (HP:0002154)2.16462581
85Small hand (HP:0200055)2.14605929
86Increased hepatocellular lipid droplets (HP:0006565)2.13968534
87Gait imbalance (HP:0002141)2.13793417
88Median cleft lip (HP:0000161)2.12213336
89Vaginal atresia (HP:0000148)2.11781396
90Pheochromocytoma (HP:0002666)2.11711181
91Congenital hepatic fibrosis (HP:0002612)2.11633731
92Short tibia (HP:0005736)2.10318737
93Supernumerary spleens (HP:0009799)2.09146383
94Progressive cerebellar ataxia (HP:0002073)2.08658531
95Lactic acidosis (HP:0003128)2.07392801
96Exercise intolerance (HP:0003546)2.06883350
97Tubular atrophy (HP:0000092)2.06765993
98Rhabdomyosarcoma (HP:0002859)2.05920899
99Neuroendocrine neoplasm (HP:0100634)2.05567121
100Abnormality of midbrain morphology (HP:0002418)2.03961378
101Molar tooth sign on MRI (HP:0002419)2.03961378
102Sclerocornea (HP:0000647)2.03535533
103Postaxial foot polydactyly (HP:0001830)2.03473141
104Premature graying of hair (HP:0002216)2.03056380
105Methylmalonic aciduria (HP:0012120)2.02975815
106Chorioretinal atrophy (HP:0000533)2.02578350
107Polydipsia (HP:0001959)2.02005448
108Abnormal drinking behavior (HP:0030082)2.02005448
109Aplasia/Hypoplasia of the uvula (HP:0010293)2.01768840
110Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.01646347
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00978152
112Abnormal spermatogenesis (HP:0008669)2.00847683
113Scotoma (HP:0000575)2.00128211
114Cerebral edema (HP:0002181)1.99575969
115Beaking of vertebral bodies (HP:0004568)1.98532257
116Abnormality of the preputium (HP:0100587)1.98386717
117Furrowed tongue (HP:0000221)1.97253397
118Hypoplasia of the pons (HP:0012110)1.96402202
119Large hands (HP:0001176)1.95343769
120Abnormality of the labia minora (HP:0012880)1.94437527
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94175566
122Dicarboxylic aciduria (HP:0003215)1.94175566
123Genetic anticipation (HP:0003743)1.94173965
124Preaxial hand polydactyly (HP:0001177)1.93473681
125Cystic liver disease (HP:0006706)1.93108086
126Abolished electroretinogram (ERG) (HP:0000550)1.92894416
127Lipid accumulation in hepatocytes (HP:0006561)1.92581980
128Increased intramyocellular lipid droplets (HP:0012240)1.92492099
129Abnormality of the pons (HP:0007361)1.91811065
130Increased corneal curvature (HP:0100692)1.91777963
131Keratoconus (HP:0000563)1.91777963
132Oculomotor apraxia (HP:0000657)1.90918375
133Brushfield spots (HP:0001088)1.90803257
134Renal Fanconi syndrome (HP:0001994)1.89741389
135Male pseudohermaphroditism (HP:0000037)1.89460125
136Abnormal ciliary motility (HP:0012262)1.89414977
137Proximal tubulopathy (HP:0000114)1.89064774
138Lymphoma (HP:0002665)1.88992531
139Neoplasm of the adrenal gland (HP:0100631)1.88782219
140Hypochromic anemia (HP:0001931)1.87760863
141Febrile seizures (HP:0002373)1.87671071
142Intestinal atresia (HP:0011100)1.86499056
143Abnormality of serine family amino acid metabolism (HP:0010894)1.86436887
144Abnormality of glycine metabolism (HP:0010895)1.86436887
145Myelodysplasia (HP:0002863)1.86230413
146Astigmatism (HP:0000483)1.86088338
147Hyperventilation (HP:0002883)1.86051846
148Oral leukoplakia (HP:0002745)1.85202275
149Chromsome breakage (HP:0040012)1.84366108
150Optic disc pallor (HP:0000543)1.84281972
151Postaxial hand polydactyly (HP:0001162)1.83652527
152Abnormality of the ileum (HP:0001549)1.83627187
153Abnormality of serum amino acid levels (HP:0003112)1.83451361
154Bone marrow hypocellularity (HP:0005528)1.83175577
155Respiratory failure (HP:0002878)1.82915674
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82640887
157Acute lymphatic leukemia (HP:0006721)1.82366889
158Bony spicule pigmentary retinopathy (HP:0007737)1.82115629
159Exertional dyspnea (HP:0002875)1.81291977
160Pancytopenia (HP:0001876)1.81227733
161Anencephaly (HP:0002323)1.80029877
162Polyuria (HP:0000103)1.79280637
163Meckel diverticulum (HP:0002245)1.79161453
164Sloping forehead (HP:0000340)1.77476512
165Conjugated hyperbilirubinemia (HP:0002908)1.77303277
166Congenital sensorineural hearing impairment (HP:0008527)1.77248328
1673-Methylglutaconic aciduria (HP:0003535)1.77145269
168Abnormality of B cell number (HP:0010975)1.77054444
169B lymphocytopenia (HP:0010976)1.77054444
170Poor suck (HP:0002033)1.76202991
171Poor coordination (HP:0002370)1.75286075
172Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74713337
173Bifid tongue (HP:0010297)1.74359857
174Abnormality of urine glucose concentration (HP:0011016)1.74012236
175Glycosuria (HP:0003076)1.74012236
176Optic nerve hypoplasia (HP:0000609)1.73324330
177Abnormality of pyrimidine metabolism (HP:0004353)1.72780263
178Megaloblastic anemia (HP:0001889)1.72183357
179Aplasia/Hypoplasia of the thymus (HP:0010515)1.71626424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.31370469
2STK164.04199428
3MAP3K123.83796392
4EIF2AK13.54931224
5BRSK22.81797667
6VRK12.79182100
7NEK12.68741033
8CASK2.53573982
9EIF2AK32.52158365
10WEE12.50929276
11MAP2K72.48137696
12BCKDK2.42659908
13BUB12.34609986
14WNK32.30154045
15BMPR1B2.29315974
16GRK12.24009490
17PINK12.23159492
18MAPKAPK32.19878659
19CDC72.15059671
20OXSR12.06348038
21SRPK11.96682808
22KIT1.91440861
23PRPF4B1.88957531
24STK31.80523645
25MYLK1.76158603
26CDK191.70872366
27CCNB11.68465871
28NEK21.60910692
29MAP4K21.57966295
30ZAK1.55689957
31TRIM281.51806402
32PDK21.51498329
33BRSK11.49273956
34PNCK1.48492630
35ACVR1B1.46791788
36RPS6KB21.39553377
37STK391.38648699
38MAPK131.38559028
39ADRBK21.36230113
40MAP4K11.34048924
41OBSCN1.33559587
42MAP2K41.28422767
43BCR1.28357635
44AKT31.28165551
45TLK11.25970706
46CDK81.24509074
47EEF2K1.22164037
48INSRR1.21824169
49MAP2K61.20914070
50STK101.20679270
51VRK21.19921328
52TXK1.19498729
53LATS11.18253372
54MAP3K41.17287307
55TAOK31.15651795
56PLK41.14627707
57SGK21.13809182
58PLK31.11119094
59WNK41.10452541
60PLK11.06810922
61TSSK61.06598548
62CDK31.05037461
63PAK31.01653877
64MKNK10.99946986
65BRD40.98987888
66EIF2AK20.96842861
67MUSK0.96248492
68ERBB30.95801939
69CSF1R0.95106093
70AURKB0.93772720
71LIMK10.92095018
72CSNK1G30.90941947
73MKNK20.89538354
74TRPM70.89387167
75SIK30.88398407
76MAP2K30.87415863
77PRKCE0.86322616
78PLK20.85841235
79TAOK20.82830906
80PASK0.81523546
81NUAK10.79380712
82TEC0.78426746
83TNIK0.77110781
84RPS6KA40.74475985
85NME10.74300434
86ATR0.74283365
87FLT30.72845711
88NLK0.72612852
89NEK60.70703260
90CSNK1G20.69547578
91STK240.67920274
92ADRBK10.67060171
93PRKCG0.66996260
94TGFBR10.66882496
95CSNK1A1L0.66449545
96CHEK20.65596665
97IRAK40.64439964
98PBK0.63641823
99PTK2B0.63402232
100CSNK1G10.63116518
101TYK20.62946233
102MET0.61214904
103MAP3K110.60325326
104MAP3K30.60200626
105BRAF0.60041134
106TAF10.58580130
107YES10.58320543
108DYRK20.57951979
109BMPR20.57423803
110NTRK30.57419363
111MST40.56161367
112MATK0.55843092
113FER0.55500893
114MAP3K70.54667216
115STK38L0.54108862
116MAP3K80.53636337
117BTK0.52964858
118CAMKK20.52256344
119FGFR20.51854005
120GRK70.51761233
121TTK0.51675579
122PAK40.50710764
123MAPKAPK50.46980009
124AURKA0.46619727
125CLK10.45387252
126PIK3CA0.45318101
127EPHA30.44862279
128PHKG10.44494680
129PHKG20.44494680
130PDK40.43543594
131PDK30.43543594
132RPS6KB10.43487843
133PRKAA20.43087848
134TIE10.41486305
135MAPKAPK20.40908267
136PRKCI0.40028175
137ITK0.39836394
138SGK2230.39198700
139SGK4940.39198700
140MARK30.39031172
141FGFR40.38944368
142PRKAA10.38382977
143CSNK2A10.38094500
144FGFR10.37591153
145CAMK2A0.36894300
146MOS0.35942052
147ATM0.33926212
148LYN0.33762216
149PIM20.32410594
150FGFR30.31455621
151SYK0.30587875
152MELK0.30500634

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61993082
2Mismatch repair_Homo sapiens_hsa034303.72381677
3Proteasome_Homo sapiens_hsa030503.37153037
4Homologous recombination_Homo sapiens_hsa034403.23069550
5Protein export_Homo sapiens_hsa030602.67659103
6RNA polymerase_Homo sapiens_hsa030202.62117036
7Ribosome_Homo sapiens_hsa030102.24198610
8Nucleotide excision repair_Homo sapiens_hsa034202.22217011
9Pyrimidine metabolism_Homo sapiens_hsa002402.19028013
10Cell cycle_Homo sapiens_hsa041102.16401562
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12884839
12Basal transcription factors_Homo sapiens_hsa030222.11571983
13Base excision repair_Homo sapiens_hsa034102.06891057
14Fatty acid elongation_Homo sapiens_hsa000622.05497289
15One carbon pool by folate_Homo sapiens_hsa006702.02932016
16Parkinsons disease_Homo sapiens_hsa050121.94822909
17Fanconi anemia pathway_Homo sapiens_hsa034601.94296046
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90586247
19Spliceosome_Homo sapiens_hsa030401.86306897
20Phototransduction_Homo sapiens_hsa047441.82360656
21Oxidative phosphorylation_Homo sapiens_hsa001901.80838177
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72180420
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69175494
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66004668
25Olfactory transduction_Homo sapiens_hsa047401.61921388
26RNA degradation_Homo sapiens_hsa030181.58590857
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58417406
28Nitrogen metabolism_Homo sapiens_hsa009101.55008311
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.54081364
30Purine metabolism_Homo sapiens_hsa002301.51685839
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49396308
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48873169
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.48495618
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46415779
35Folate biosynthesis_Homo sapiens_hsa007901.44334664
36Huntingtons disease_Homo sapiens_hsa050161.44203206
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41479536
38Caffeine metabolism_Homo sapiens_hsa002321.33845532
39Pyruvate metabolism_Homo sapiens_hsa006201.31894982
40Propanoate metabolism_Homo sapiens_hsa006401.30628058
41Non-homologous end-joining_Homo sapiens_hsa034501.25402377
42Histidine metabolism_Homo sapiens_hsa003401.20359475
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20112822
44Ether lipid metabolism_Homo sapiens_hsa005651.17492613
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16519686
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.13736219
47Biosynthesis of amino acids_Homo sapiens_hsa012301.13652533
48RNA transport_Homo sapiens_hsa030131.11895045
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.11829755
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11255163
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09791814
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09531866
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06762010
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06754157
55Cardiac muscle contraction_Homo sapiens_hsa042601.06240893
56Fatty acid degradation_Homo sapiens_hsa000711.05504756
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04800350
58Circadian rhythm_Homo sapiens_hsa047101.02111162
59Carbon metabolism_Homo sapiens_hsa012001.01923230
60Pentose phosphate pathway_Homo sapiens_hsa000300.96904378
61Glutathione metabolism_Homo sapiens_hsa004800.95775874
62Selenocompound metabolism_Homo sapiens_hsa004500.94530658
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93564032
64Fatty acid metabolism_Homo sapiens_hsa012120.92017819
65Epstein-Barr virus infection_Homo sapiens_hsa051690.90918446
66Alzheimers disease_Homo sapiens_hsa050100.89538263
67p53 signaling pathway_Homo sapiens_hsa041150.89252476
68Taste transduction_Homo sapiens_hsa047420.85451210
69Peroxisome_Homo sapiens_hsa041460.84157383
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82499623
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80661068
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79604007
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79556127
74beta-Alanine metabolism_Homo sapiens_hsa004100.79188211
75Regulation of autophagy_Homo sapiens_hsa041400.78810647
76Metabolic pathways_Homo sapiens_hsa011000.76012879
77TGF-beta signaling pathway_Homo sapiens_hsa043500.75041861
78Serotonergic synapse_Homo sapiens_hsa047260.74421710
79Arginine and proline metabolism_Homo sapiens_hsa003300.74229785
80Nicotine addiction_Homo sapiens_hsa050330.73507747
81Morphine addiction_Homo sapiens_hsa050320.72303347
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71482710
83Arachidonic acid metabolism_Homo sapiens_hsa005900.64820295
84Vitamin B6 metabolism_Homo sapiens_hsa007500.63861079
85Insulin secretion_Homo sapiens_hsa049110.63028401
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62282797
87Lysine degradation_Homo sapiens_hsa003100.60836739
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60502071
89Herpes simplex infection_Homo sapiens_hsa051680.59282386
90GABAergic synapse_Homo sapiens_hsa047270.58219910
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57444813
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55730960
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54866137
94ABC transporters_Homo sapiens_hsa020100.54476252
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54020896
96Sulfur metabolism_Homo sapiens_hsa009200.53641963
97Calcium signaling pathway_Homo sapiens_hsa040200.53145340
98N-Glycan biosynthesis_Homo sapiens_hsa005100.51296887
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50336170
100Hematopoietic cell lineage_Homo sapiens_hsa046400.50079756
101Oocyte meiosis_Homo sapiens_hsa041140.49427146
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.48235902
103Fatty acid biosynthesis_Homo sapiens_hsa000610.47505314
104Hedgehog signaling pathway_Homo sapiens_hsa043400.46288610
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45415263
106Fat digestion and absorption_Homo sapiens_hsa049750.44480905
107Hippo signaling pathway_Homo sapiens_hsa043900.43731061
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.43612951
109Ovarian steroidogenesis_Homo sapiens_hsa049130.43488472
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42548290
111Tryptophan metabolism_Homo sapiens_hsa003800.42241751
112Renin secretion_Homo sapiens_hsa049240.41427409
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41308071
114Retinol metabolism_Homo sapiens_hsa008300.40765567
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40480627
116Butanoate metabolism_Homo sapiens_hsa006500.39802808
117Primary immunodeficiency_Homo sapiens_hsa053400.39427435
118Steroid biosynthesis_Homo sapiens_hsa001000.38677488
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35744134
120Chemical carcinogenesis_Homo sapiens_hsa052040.34723339
121Viral carcinogenesis_Homo sapiens_hsa052030.34393788
122Vitamin digestion and absorption_Homo sapiens_hsa049770.30568848
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.29449629
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28144059
125Autoimmune thyroid disease_Homo sapiens_hsa053200.24803236
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24373874
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22350900
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19667033
129Linoleic acid metabolism_Homo sapiens_hsa005910.19609439
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19403655
131Phenylalanine metabolism_Homo sapiens_hsa003600.19289572
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18196697
133Fructose and mannose metabolism_Homo sapiens_hsa000510.17387657
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16103416
135Measles_Homo sapiens_hsa051620.14590602

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »