METTL15P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1platelet dense granule organization (GO:0060155)5.47693654
2oligosaccharide biosynthetic process (GO:0009312)4.94349593
3response to pheromone (GO:0019236)4.81650771
4epithelial cilium movement (GO:0003351)4.61971302
5DNA double-strand break processing (GO:0000729)4.38037171
6proteasome assembly (GO:0043248)4.28988880
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.27534861
8anterograde synaptic vesicle transport (GO:0048490)4.05062991
9regulation of triglyceride catabolic process (GO:0010896)4.02214106
10cilium movement (GO:0003341)3.79419206
11axoneme assembly (GO:0035082)3.78387738
12axonemal dynein complex assembly (GO:0070286)3.75382961
13cell wall macromolecule catabolic process (GO:0016998)3.67561307
14meiotic chromosome segregation (GO:0045132)3.62690948
15intraciliary transport (GO:0042073)3.55629702
16regulation of cilium movement (GO:0003352)3.55148677
17DNA deamination (GO:0045006)3.47876472
18replication fork processing (GO:0031297)3.29717212
19centriole replication (GO:0007099)3.27806055
20sequestering of actin monomers (GO:0042989)3.27340038
21water-soluble vitamin biosynthetic process (GO:0042364)3.25018887
22retinal cone cell development (GO:0046549)3.23341284
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.18625283
24positive regulation of mitochondrial fission (GO:0090141)3.13802129
25peroxisome fission (GO:0016559)3.10427223
26mannosylation (GO:0097502)3.09009325
27sperm motility (GO:0030317)3.07792385
28high-density lipoprotein particle remodeling (GO:0034375)3.05076002
29negative regulation of smooth muscle cell differentiation (GO:0051151)3.01531968
30cell wall macromolecule metabolic process (GO:0044036)2.98430634
31lipopolysaccharide biosynthetic process (GO:0009103)2.94208439
32reverse cholesterol transport (GO:0043691)2.93961121
33retinal rod cell development (GO:0046548)2.93181714
34male sex determination (GO:0030238)2.92026429
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91364906
36estrogen biosynthetic process (GO:0006703)2.87013009
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85877257
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85877257
39protein complex biogenesis (GO:0070271)2.85152297
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84541562
41dopamine transport (GO:0015872)2.83002953
42adenosine metabolic process (GO:0046085)2.82991992
43DNA integration (GO:0015074)2.80895879
44photoreceptor cell development (GO:0042461)2.80464168
45cilium morphogenesis (GO:0060271)2.80462989
46somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80424393
47isotype switching (GO:0045190)2.80424393
48somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80424393
49limb bud formation (GO:0060174)2.76803846
50eye photoreceptor cell development (GO:0042462)2.74949031
51aldehyde catabolic process (GO:0046185)2.74067558
52regulation of immunoglobulin secretion (GO:0051023)2.69650882
53intracellular protein transmembrane import (GO:0044743)2.66253447
54protein-cofactor linkage (GO:0018065)2.65483422
55protein K11-linked deubiquitination (GO:0035871)2.64256088
56ubiquinone biosynthetic process (GO:0006744)2.62443312
57DNA damage response, detection of DNA damage (GO:0042769)2.62206517
58mitochondrial respiratory chain complex assembly (GO:0033108)2.61789363
59recombinational repair (GO:0000725)2.61273179
60positive regulation of glycoprotein biosynthetic process (GO:0010560)2.61240888
61amine catabolic process (GO:0009310)2.57812755
62cellular biogenic amine catabolic process (GO:0042402)2.57812755
63GPI anchor metabolic process (GO:0006505)2.56993846
64nonmotile primary cilium assembly (GO:0035058)2.56244789
65NADH dehydrogenase complex assembly (GO:0010257)2.55758673
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55758673
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.55758673
68double-strand break repair via homologous recombination (GO:0000724)2.54345595
69kinetochore assembly (GO:0051382)2.52218892
70purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.51787267
71protein polyglutamylation (GO:0018095)2.51181294
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51047965
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49216253
74prenylation (GO:0097354)2.46448172
75protein prenylation (GO:0018342)2.46448172
76protein localization to cilium (GO:0061512)2.45682534
77polyol catabolic process (GO:0046174)2.44921344
78neural tube formation (GO:0001841)2.44484817
79L-fucose catabolic process (GO:0042355)2.44203985
80fucose catabolic process (GO:0019317)2.44203985
81L-fucose metabolic process (GO:0042354)2.44203985
82phospholipid efflux (GO:0033700)2.44012858
83anterograde axon cargo transport (GO:0008089)2.43377362
84cilium organization (GO:0044782)2.43112538
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40559961
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40559961
87GMP metabolic process (GO:0046037)2.39829278
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39570025
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39570025
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39570025
91positive regulation of T cell cytokine production (GO:0002726)2.39530708
92kinetochore organization (GO:0051383)2.39162518
93C-terminal protein lipidation (GO:0006501)2.36626654
94positive regulation of triglyceride biosynthetic process (GO:0010867)2.36377641
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.35810425
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.35546409
97ubiquinone metabolic process (GO:0006743)2.35482217
98protein targeting to peroxisome (GO:0006625)2.35209895
99establishment of protein localization to peroxisome (GO:0072663)2.35209895
100protein localization to peroxisome (GO:0072662)2.35209895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.32543664
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08314842
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00829145
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.87841842
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85099458
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.77057242
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48888761
8IGF1R_20145208_ChIP-Seq_DFB_Human2.47436947
9GBX2_23144817_ChIP-Seq_PC3_Human2.38921645
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36848772
11ELK1_19687146_ChIP-ChIP_HELA_Human2.34299056
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29392851
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.29224922
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.26884194
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23958266
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21497544
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20961888
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19590628
19FUS_26573619_Chip-Seq_HEK293_Human2.17450613
20VDR_22108803_ChIP-Seq_LS180_Human2.16585170
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09688092
22P300_19829295_ChIP-Seq_ESCs_Human2.03670742
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92475846
24VDR_23849224_ChIP-Seq_CD4+_Human1.89277132
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89194352
26EWS_26573619_Chip-Seq_HEK293_Human1.86618906
27MYC_18940864_ChIP-ChIP_HL60_Human1.79332998
28TAF15_26573619_Chip-Seq_HEK293_Human1.77440983
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.75785006
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70275643
31GATA1_22025678_ChIP-Seq_K562_Human1.62213340
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60891806
33CBP_20019798_ChIP-Seq_JUKART_Human1.60891806
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60254382
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56159857
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54267120
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52166451
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.50591614
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50287069
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49827487
41ER_23166858_ChIP-Seq_MCF-7_Human1.48803002
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46615604
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46369742
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44363371
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.44204490
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44204490
47TP53_22573176_ChIP-Seq_HFKS_Human1.43936020
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39978973
49AR_25329375_ChIP-Seq_VCAP_Human1.39550873
50IRF1_19129219_ChIP-ChIP_H3396_Human1.38913940
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.38561153
52EZH2_22144423_ChIP-Seq_EOC_Human1.36955631
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35953131
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34871696
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34375260
56FOXP3_21729870_ChIP-Seq_TREG_Human1.33646204
57NANOG_19829295_ChIP-Seq_ESCs_Human1.31706454
58SOX2_19829295_ChIP-Seq_ESCs_Human1.31706454
59AR_21572438_ChIP-Seq_LNCaP_Human1.30353117
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29440172
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28761082
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.27659233
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27346227
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27230918
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26661042
66STAT3_23295773_ChIP-Seq_U87_Human1.25781017
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25229627
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23458001
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.22719765
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20307327
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19081548
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17864096
73AR_20517297_ChIP-Seq_VCAP_Human1.16671949
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.16596660
75SMAD4_21799915_ChIP-Seq_A2780_Human1.16113295
76TCF4_23295773_ChIP-Seq_U87_Human1.15961831
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14950996
78CDX2_22108803_ChIP-Seq_LS180_Human1.13531399
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13291732
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12397677
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11000802
82BCAT_22108803_ChIP-Seq_LS180_Human1.09173109
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08584235
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06234076
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04815825
86TCF4_22108803_ChIP-Seq_LS180_Human1.04353915
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03725847
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.03330914
89GATA3_26560356_Chip-Seq_TH2_Human1.03291495
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02116437
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01936869
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00978350
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.00203212
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98371815
95P53_22387025_ChIP-Seq_ESCs_Mouse0.98031586
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97980858
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.96117407
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95980910
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95462855
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.95178432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.76442589
2MP0003136_yellow_coat_color3.25049597
3MP0000566_synostosis3.06821222
4MP0002102_abnormal_ear_morphology2.92696931
5MP0001529_abnormal_vocalization2.86788781
6MP0006072_abnormal_retinal_apoptosis2.66199808
7MP0009840_abnormal_foam_cell2.35199742
8MP0003806_abnormal_nucleotide_metabolis2.21879934
9MP0005084_abnormal_gallbladder_morpholo2.14086799
10MP0005253_abnormal_eye_physiology2.11527918
11MP0005551_abnormal_eye_electrophysiolog2.11153994
12MP0005174_abnormal_tail_pigmentation2.09568381
13MP0000372_irregular_coat_pigmentation2.02607862
14MP0009697_abnormal_copulation1.92942340
15MP0002938_white_spotting1.88413869
16MP0002095_abnormal_skin_pigmentation1.84641686
17MP0003252_abnormal_bile_duct1.83239642
18MP0008877_abnormal_DNA_methylation1.81903779
19MP0001984_abnormal_olfaction1.76380087
20MP0008058_abnormal_DNA_repair1.72346959
21MP0000427_abnormal_hair_cycle1.70782221
22MP0002282_abnormal_trachea_morphology1.67328287
23MP0002876_abnormal_thyroid_physiology1.65050757
24MP0004142_abnormal_muscle_tone1.56062494
25MP0005171_absent_coat_pigmentation1.54182290
26MP0010329_abnormal_lipoprotein_level1.53199666
27MP0005075_abnormal_melanosome_morpholog1.52435728
28MP0001764_abnormal_homeostasis1.49520767
29MP0005310_abnormal_salivary_gland1.48144625
30MP0000647_abnormal_sebaceous_gland1.44669357
31MP0002638_abnormal_pupillary_reflex1.43723250
32MP0002928_abnormal_bile_duct1.42479778
33MP0003011_delayed_dark_adaptation1.37291211
34MP0005187_abnormal_penis_morphology1.35788823
35MP0005671_abnormal_response_to1.34865709
36MP0003718_maternal_effect1.34604227
37MP0002653_abnormal_ependyma_morphology1.34161404
38MP0004145_abnormal_muscle_electrophysio1.28798017
39MP0003283_abnormal_digestive_organ1.28522282
40MP0010094_abnormal_chromosome_stability1.25198671
41MP0001177_atelectasis1.20795138
42MP0001968_abnormal_touch/_nociception1.20669295
43MP0003950_abnormal_plasma_membrane1.20652956
44MP0005410_abnormal_fertilization1.16657860
45MP0002254_reproductive_system_inflammat1.15004828
46MP0001929_abnormal_gametogenesis1.14643374
47MP0005645_abnormal_hypothalamus_physiol1.14035375
48MP0008995_early_reproductive_senescence1.12929692
49MP0003937_abnormal_limbs/digits/tail_de1.11301977
50MP0000383_abnormal_hair_follicle1.10454016
51MP0001485_abnormal_pinna_reflex1.09716150
52MP0001486_abnormal_startle_reflex1.07044461
53MP0005360_urolithiasis1.05847284
54MP0002837_dystrophic_cardiac_calcinosis1.04460775
55MP0002822_catalepsy1.04393828
56MP0003186_abnormal_redox_activity1.03827913
57MP0008872_abnormal_physiological_respon1.03808419
58MP0009046_muscle_twitch1.03188177
59MP0001986_abnormal_taste_sensitivity1.02212548
60MP0001324_abnormal_eye_pigmentation0.99356400
61MP0002751_abnormal_autonomic_nervous0.98821952
62MP0003646_muscle_fatigue0.98589127
63MP0001119_abnormal_female_reproductive0.94910583
64MP0003786_premature_aging0.93244088
65MP0000371_diluted_coat_color0.92838763
66MP0002736_abnormal_nociception_after0.92785321
67MP0005670_abnormal_white_adipose0.91236066
68MP0001835_abnormal_antigen_presentation0.89683728
69MP0000653_abnormal_sex_gland0.89223779
70MP0000613_abnormal_salivary_gland0.88088169
71MP0003195_calcinosis0.87099580
72MP0002557_abnormal_social/conspecific_i0.86815642
73MP0008007_abnormal_cellular_replicative0.86782172
74MP0002277_abnormal_respiratory_mucosa0.86319473
75MP0008875_abnormal_xenobiotic_pharmacok0.85549925
76MP0004885_abnormal_endolymph0.85363115
77MP0005386_behavior/neurological_phenoty0.83294229
78MP0004924_abnormal_behavior0.83294229
79MP0004133_heterotaxia0.82652495
80MP0002210_abnormal_sex_determination0.81792962
81MP0003183_abnormal_peptide_metabolism0.80405996
82MP0006036_abnormal_mitochondrial_physio0.80144587
83MP0005646_abnormal_pituitary_gland0.79158746
84MP0001293_anophthalmia0.78705499
85MP0010386_abnormal_urinary_bladder0.78315591
86MP0004043_abnormal_pH_regulation0.77253083
87MP0001800_abnormal_humoral_immune0.77075915
88MP0008961_abnormal_basal_metabolism0.74523382
89MP0003698_abnormal_male_reproductive0.74484759
90MP0009745_abnormal_behavioral_response0.73349886
91MP0006082_CNS_inflammation0.72651257
92MP0000631_abnormal_neuroendocrine_gland0.72476333
93MP0000639_abnormal_adrenal_gland0.71873459
94MP0000015_abnormal_ear_pigmentation0.71722065
95MP0003191_abnormal_cellular_cholesterol0.69029494
96MP0001145_abnormal_male_reproductive0.68587347
97MP0001963_abnormal_hearing_physiology0.67773102
98MP0002234_abnormal_pharynx_morphology0.67500457
99MP0005195_abnormal_posterior_eye0.66570739
100MP0005085_abnormal_gallbladder_physiolo0.64952128

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.68690857
2Pancreatic cysts (HP:0001737)3.67398321
3Hyperglycinemia (HP:0002154)3.47460985
4Large for gestational age (HP:0001520)3.34692786
5Renal cortical cysts (HP:0000803)3.25189732
6Abnormality of the renal cortex (HP:0011035)3.21777576
7Intestinal atresia (HP:0011100)3.20601947
8Abnormality of midbrain morphology (HP:0002418)3.18272773
9Molar tooth sign on MRI (HP:0002419)3.18272773
10Pancreatic fibrosis (HP:0100732)3.16175650
11Medial flaring of the eyebrow (HP:0010747)3.11058221
12Albinism (HP:0001022)3.06237406
13Abnormality of the pons (HP:0007361)3.03833467
14Tubulointerstitial nephritis (HP:0001970)2.98136965
15Congenital primary aphakia (HP:0007707)2.96374306
16Chronic hepatic failure (HP:0100626)2.92578230
17B lymphocytopenia (HP:0010976)2.86475853
18Hypoplasia of the pons (HP:0012110)2.86082182
19Abnormality of B cell number (HP:0010975)2.85154483
20Gait imbalance (HP:0002141)2.80637846
21Methylmalonic acidemia (HP:0002912)2.74302041
22Hypobetalipoproteinemia (HP:0003563)2.72117396
23Hyperglycinuria (HP:0003108)2.67205691
24Abnormality of the phalanges of the 2nd finger (HP:0009541)2.65607008
25Pendular nystagmus (HP:0012043)2.62335837
26Abnormality of serine family amino acid metabolism (HP:0010894)2.58085215
27Abnormality of glycine metabolism (HP:0010895)2.58085215
28Nephrogenic diabetes insipidus (HP:0009806)2.58032111
29Volvulus (HP:0002580)2.54599397
30Chronic sinusitis (HP:0011109)2.51292799
31Genital tract atresia (HP:0001827)2.49110915
32Abnormality of the labia minora (HP:0012880)2.48940332
33Vaginal atresia (HP:0000148)2.48926538
34Thyroiditis (HP:0100646)2.45571250
35Abnormal respiratory motile cilium morphology (HP:0005938)2.45328478
36Abnormal respiratory epithelium morphology (HP:0012253)2.45328478
37Abolished electroretinogram (ERG) (HP:0000550)2.40921732
38Abnormal ciliary motility (HP:0012262)2.39528203
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38808249
40Nephronophthisis (HP:0000090)2.35765285
41Abnormal respiratory motile cilium physiology (HP:0012261)2.35641644
42Abnormality of the renal medulla (HP:0100957)2.32323938
43Thyroid-stimulating hormone excess (HP:0002925)2.29787158
44Type II lissencephaly (HP:0007260)2.25906186
45Abnormality of macular pigmentation (HP:0008002)2.23153588
46Gastrointestinal atresia (HP:0002589)2.22748002
47Type I transferrin isoform profile (HP:0003642)2.19380553
48Brushfield spots (HP:0001088)2.17996244
49Short tibia (HP:0005736)2.15515712
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.15127443
51Cystic liver disease (HP:0006706)2.13971645
52Methylmalonic aciduria (HP:0012120)2.13895975
53Attenuation of retinal blood vessels (HP:0007843)2.13460172
54Synostosis involving the elbow (HP:0003938)2.12660207
55Humeroradial synostosis (HP:0003041)2.12660207
56Absent/shortened dynein arms (HP:0200106)2.12384238
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.12384238
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.11696535
59Neonatal respiratory distress (HP:0002643)2.11576150
60Acute necrotizing encephalopathy (HP:0006965)2.03061519
61Abnormality of vitamin B metabolism (HP:0004340)2.02686062
62Tubulointerstitial abnormality (HP:0001969)2.00604280
63Optic disc pallor (HP:0000543)1.99529722
64Broad foot (HP:0001769)1.99513553
65Acute encephalopathy (HP:0006846)1.98336013
66Abnormality of the vitamin B12 metabolism (HP:0004341)1.97473929
67Congenital, generalized hypertrichosis (HP:0004540)1.94896587
68Severe combined immunodeficiency (HP:0004430)1.94877741
69Recurrent bronchitis (HP:0002837)1.93707330
70Decreased central vision (HP:0007663)1.92861831
71Progressive inability to walk (HP:0002505)1.92477820
72Cerebellar dysplasia (HP:0007033)1.91423304
73Hyperventilation (HP:0002883)1.90924857
74Preaxial hand polydactyly (HP:0001177)1.90496295
75Increased CSF lactate (HP:0002490)1.90366152
76Tented upper lip vermilion (HP:0010804)1.89996295
77Poor coordination (HP:0002370)1.89049942
78Progressive macrocephaly (HP:0004481)1.88256810
79IgG deficiency (HP:0004315)1.87068889
803-Methylglutaconic aciduria (HP:0003535)1.86577736
81Furrowed tongue (HP:0000221)1.85453475
82Postaxial hand polydactyly (HP:0001162)1.85117448
83Congenital stationary night blindness (HP:0007642)1.83341522
84Agammaglobulinemia (HP:0004432)1.83166326
85Bronchitis (HP:0012387)1.82877798
86Rhinitis (HP:0012384)1.82268042
87Congenital hepatic fibrosis (HP:0002612)1.81606983
88Mitochondrial inheritance (HP:0001427)1.80096204
89Hypomagnesemia (HP:0002917)1.79713171
90Abnormality of serum amino acid levels (HP:0003112)1.78921656
91Short foot (HP:0001773)1.78079374
92Gaze-evoked nystagmus (HP:0000640)1.77007880
93Small hand (HP:0200055)1.76797914
94Birth length less than 3rd percentile (HP:0003561)1.76284900
95Abnormal rod and cone electroretinograms (HP:0008323)1.75082023
96Male pseudohermaphroditism (HP:0000037)1.71053682
97IgM deficiency (HP:0002850)1.70677186
98Symphalangism affecting the phalanges of the hand (HP:0009773)1.69218070
99Epiphyseal stippling (HP:0010655)1.68690656
100Postaxial foot polydactyly (HP:0001830)1.67806183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.95325079
2MAP4K23.77566848
3NUAK12.92464245
4MUSK2.84803997
5FRK2.84647664
6VRK22.81181140
7MST42.52558607
8BCKDK2.50861170
9WEE12.49138936
10VRK12.30453050
11BMPR1B2.20649128
12AKT32.17508140
13BMPR22.12651044
14PIK3CG1.94643327
15BRSK21.90346629
16WNK31.79356310
17MKNK21.67467256
18STK391.67270679
19ADRBK21.55801581
20PNCK1.53916680
21PLK21.41133337
22CASK1.40130982
23NEK91.38661409
24PLK41.37235388
25OXSR11.37144097
26ZAK1.35749510
27TNIK1.34924260
28PDK21.32881960
29ERBB31.32878649
30WNK41.30670673
31PINK11.25705814
32STK161.25490648
33MAPK131.18604381
34TSSK61.17250552
35MKNK11.15457731
36FLT31.14311686
37GRK11.11162491
38MARK31.08810493
39ADRBK11.07793394
40MAP3K121.04607697
41ACVR1B1.03422539
42SRPK11.01814846
43PBK1.00440303
44TAOK30.93889965
45BRD40.93788106
46BUB10.92373300
47KIT0.88700778
48PTK2B0.88247326
49NEK10.87265278
50CSF1R0.86995542
51FGFR20.85416057
52TRIM280.84972746
53TXK0.79579527
54CCNB10.77034115
55PLK30.75844045
56STK38L0.72607968
57MAP3K20.67541568
58MAPKAPK30.66299658
59TAF10.64264703
60LATS10.61165629
61CSNK1G10.61104063
62PAK30.59615349
63PRKCE0.58408168
64KDR0.58200887
65MAP3K40.57565682
66STK100.56122361
67PLK10.53395057
68TGFBR10.53349998
69TLK10.53178575
70MET0.52807473
71GRK70.52642097
72CSNK1A1L0.51516834
73CSNK1G30.50883659
74CSNK1G20.50750254
75PRKCG0.47437486
76PIK3CA0.45382459
77GRK50.44904798
78TNK20.42549990
79FGFR10.41188567
80EIF2AK20.40408534
81NLK0.39810532
82EIF2AK30.39686802
83CDC70.38669463
84NME10.38255855
85IKBKE0.37373238
86PRKCI0.36019022
87MAP2K10.35773631
88RPS6KA50.35063348
89IGF1R0.35015536
90PIM20.34710551
91MAPK110.34498318
92OBSCN0.34015891
93PRKCQ0.33409732
94CHUK0.32475822
95MAPK150.31761972
96ERBB40.30428902
97BRSK10.30129314
98TESK20.29428013
99IKBKB0.29264607
100SYK0.28072818

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.02567598
2Protein export_Homo sapiens_hsa030602.93242708
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.88246065
4Propanoate metabolism_Homo sapiens_hsa006402.61417654
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.56548896
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46956404
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44154509
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40099060
9RNA polymerase_Homo sapiens_hsa030202.20631238
10Butanoate metabolism_Homo sapiens_hsa006502.14374126
11Non-homologous end-joining_Homo sapiens_hsa034502.01823254
12Primary immunodeficiency_Homo sapiens_hsa053401.98059148
13Asthma_Homo sapiens_hsa053101.93212506
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89143753
15Peroxisome_Homo sapiens_hsa041461.78459355
16One carbon pool by folate_Homo sapiens_hsa006701.76167399
17Basal transcription factors_Homo sapiens_hsa030221.72248697
18Homologous recombination_Homo sapiens_hsa034401.70607293
19RNA degradation_Homo sapiens_hsa030181.65698137
20Oxidative phosphorylation_Homo sapiens_hsa001901.65439508
21Phototransduction_Homo sapiens_hsa047441.61894949
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.56095525
23Systemic lupus erythematosus_Homo sapiens_hsa053221.55303323
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54753729
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52200253
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52173042
27Selenocompound metabolism_Homo sapiens_hsa004501.49696456
28Allograft rejection_Homo sapiens_hsa053301.46557405
29Autoimmune thyroid disease_Homo sapiens_hsa053201.40460628
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40154805
31Nitrogen metabolism_Homo sapiens_hsa009101.39132049
32Parkinsons disease_Homo sapiens_hsa050121.36374418
33Fanconi anemia pathway_Homo sapiens_hsa034601.35317086
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.35096343
35Linoleic acid metabolism_Homo sapiens_hsa005911.33360025
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31044255
37Purine metabolism_Homo sapiens_hsa002301.26888362
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26324987
39Chemical carcinogenesis_Homo sapiens_hsa052041.24455017
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23534003
41Steroid biosynthesis_Homo sapiens_hsa001001.20141610
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15843411
43Pyrimidine metabolism_Homo sapiens_hsa002401.14617201
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14344737
45Mismatch repair_Homo sapiens_hsa034301.13602752
46Fat digestion and absorption_Homo sapiens_hsa049751.05833455
47Retinol metabolism_Homo sapiens_hsa008301.02562001
48Fatty acid biosynthesis_Homo sapiens_hsa000611.01872478
49Nucleotide excision repair_Homo sapiens_hsa034200.98531393
50Graft-versus-host disease_Homo sapiens_hsa053320.97665192
51Tryptophan metabolism_Homo sapiens_hsa003800.95690553
52Huntingtons disease_Homo sapiens_hsa050160.95197802
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95149698
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93626307
55Sulfur metabolism_Homo sapiens_hsa009200.93438801
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92873209
57Type I diabetes mellitus_Homo sapiens_hsa049400.92602379
58p53 signaling pathway_Homo sapiens_hsa041150.90725034
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88528452
60Base excision repair_Homo sapiens_hsa034100.85016371
61RNA transport_Homo sapiens_hsa030130.79635858
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78902767
63Regulation of autophagy_Homo sapiens_hsa041400.75745965
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.75267598
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75116706
66Arachidonic acid metabolism_Homo sapiens_hsa005900.74069438
67Metabolic pathways_Homo sapiens_hsa011000.73899578
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.73889407
69Starch and sucrose metabolism_Homo sapiens_hsa005000.72889842
70Sphingolipid metabolism_Homo sapiens_hsa006000.72166432
71Nicotine addiction_Homo sapiens_hsa050330.71960450
72Antigen processing and presentation_Homo sapiens_hsa046120.71376475
73Ether lipid metabolism_Homo sapiens_hsa005650.70413983
74Vitamin digestion and absorption_Homo sapiens_hsa049770.69140474
75Alcoholism_Homo sapiens_hsa050340.65937267
76Hematopoietic cell lineage_Homo sapiens_hsa046400.65663690
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64215644
78Glycerolipid metabolism_Homo sapiens_hsa005610.63324019
79Fatty acid metabolism_Homo sapiens_hsa012120.62069949
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.61332694
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58648425
82Alzheimers disease_Homo sapiens_hsa050100.58489554
83Pyruvate metabolism_Homo sapiens_hsa006200.52965850
84Taste transduction_Homo sapiens_hsa047420.51449929
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49832432
86Mineral absorption_Homo sapiens_hsa049780.46563641
87Fatty acid degradation_Homo sapiens_hsa000710.43145288
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40838432
89beta-Alanine metabolism_Homo sapiens_hsa004100.38765094
90Fatty acid elongation_Homo sapiens_hsa000620.38522136
91DNA replication_Homo sapiens_hsa030300.38384859
92Spliceosome_Homo sapiens_hsa030400.36588281
93Olfactory transduction_Homo sapiens_hsa047400.35149705
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.33769620
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33374628
96Oocyte meiosis_Homo sapiens_hsa041140.30643663
97Salivary secretion_Homo sapiens_hsa049700.30369118
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28976041
99Glutathione metabolism_Homo sapiens_hsa004800.28744727
100ABC transporters_Homo sapiens_hsa020100.27238138

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