ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	platelet dense granule organization (GO:0060155)	5.47693654
2	oligosaccharide biosynthetic process (GO:0009312)	4.94349593
3	response to pheromone (GO:0019236)	4.81650771
4	epithelial cilium movement (GO:0003351)	4.61971302
5	DNA double-strand break processing (GO:0000729)	4.38037171
6	proteasome assembly (GO:0043248)	4.28988880
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.27534861
8	anterograde synaptic vesicle transport (GO:0048490)	4.05062991
9	regulation of triglyceride catabolic process (GO:0010896)	4.02214106
10	cilium movement (GO:0003341)	3.79419206
11	axoneme assembly (GO:0035082)	3.78387738
12	axonemal dynein complex assembly (GO:0070286)	3.75382961
13	cell wall macromolecule catabolic process (GO:0016998)	3.67561307
14	meiotic chromosome segregation (GO:0045132)	3.62690948
15	intraciliary transport (GO:0042073)	3.55629702
16	regulation of cilium movement (GO:0003352)	3.55148677
17	DNA deamination (GO:0045006)	3.47876472
18	replication fork processing (GO:0031297)	3.29717212
19	centriole replication (GO:0007099)	3.27806055
20	sequestering of actin monomers (GO:0042989)	3.27340038
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.25018887
22	retinal cone cell development (GO:0046549)	3.23341284
23	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.18625283
24	positive regulation of mitochondrial fission (GO:0090141)	3.13802129
25	peroxisome fission (GO:0016559)	3.10427223
26	mannosylation (GO:0097502)	3.09009325
27	sperm motility (GO:0030317)	3.07792385
28	high-density lipoprotein particle remodeling (GO:0034375)	3.05076002
29	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.01531968
30	cell wall macromolecule metabolic process (GO:0044036)	2.98430634
31	lipopolysaccharide biosynthetic process (GO:0009103)	2.94208439
32	reverse cholesterol transport (GO:0043691)	2.93961121
33	retinal rod cell development (GO:0046548)	2.93181714
34	male sex determination (GO:0030238)	2.92026429
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.91364906
36	estrogen biosynthetic process (GO:0006703)	2.87013009
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85877257
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85877257
39	protein complex biogenesis (GO:0070271)	2.85152297
40	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.84541562
41	dopamine transport (GO:0015872)	2.83002953
42	adenosine metabolic process (GO:0046085)	2.82991992
43	DNA integration (GO:0015074)	2.80895879
44	photoreceptor cell development (GO:0042461)	2.80464168
45	cilium morphogenesis (GO:0060271)	2.80462989
46	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.80424393
47	isotype switching (GO:0045190)	2.80424393
48	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.80424393
49	limb bud formation (GO:0060174)	2.76803846
50	eye photoreceptor cell development (GO:0042462)	2.74949031
51	aldehyde catabolic process (GO:0046185)	2.74067558
52	regulation of immunoglobulin secretion (GO:0051023)	2.69650882
53	intracellular protein transmembrane import (GO:0044743)	2.66253447
54	protein-cofactor linkage (GO:0018065)	2.65483422
55	protein K11-linked deubiquitination (GO:0035871)	2.64256088
56	ubiquinone biosynthetic process (GO:0006744)	2.62443312
57	DNA damage response, detection of DNA damage (GO:0042769)	2.62206517
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.61789363
59	recombinational repair (GO:0000725)	2.61273179
60	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.61240888
61	amine catabolic process (GO:0009310)	2.57812755
62	cellular biogenic amine catabolic process (GO:0042402)	2.57812755
63	GPI anchor metabolic process (GO:0006505)	2.56993846
64	nonmotile primary cilium assembly (GO:0035058)	2.56244789
65	NADH dehydrogenase complex assembly (GO:0010257)	2.55758673
66	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55758673
67	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55758673
68	double-strand break repair via homologous recombination (GO:0000724)	2.54345595
69	kinetochore assembly (GO:0051382)	2.52218892
70	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.51787267
71	protein polyglutamylation (GO:0018095)	2.51181294
72	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51047965
73	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.49216253
74	prenylation (GO:0097354)	2.46448172
75	protein prenylation (GO:0018342)	2.46448172
76	protein localization to cilium (GO:0061512)	2.45682534
77	polyol catabolic process (GO:0046174)	2.44921344
78	neural tube formation (GO:0001841)	2.44484817
79	L-fucose catabolic process (GO:0042355)	2.44203985
80	fucose catabolic process (GO:0019317)	2.44203985
81	L-fucose metabolic process (GO:0042354)	2.44203985
82	phospholipid efflux (GO:0033700)	2.44012858
83	anterograde axon cargo transport (GO:0008089)	2.43377362
84	cilium organization (GO:0044782)	2.43112538
85	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.40559961
86	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.40559961
87	GMP metabolic process (GO:0046037)	2.39829278
88	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.39570025
89	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.39570025
90	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.39570025
91	positive regulation of T cell cytokine production (GO:0002726)	2.39530708
92	kinetochore organization (GO:0051383)	2.39162518
93	C-terminal protein lipidation (GO:0006501)	2.36626654
94	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.36377641
95	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.35810425
96	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.35546409
97	ubiquinone metabolic process (GO:0006743)	2.35482217
98	protein targeting to peroxisome (GO:0006625)	2.35209895
99	establishment of protein localization to peroxisome (GO:0072663)	2.35209895
100	protein localization to peroxisome (GO:0072662)	2.35209895

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.32543664
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.08314842
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.00829145
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.87841842
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.85099458
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.77057242
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48888761
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47436947
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.38921645
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.36848772
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34299056
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29392851
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.29224922
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26884194
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23958266
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21497544
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.20961888
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19590628
19	FUS_26573619_Chip-Seq_HEK293_Human	2.17450613
20	VDR_22108803_ChIP-Seq_LS180_Human	2.16585170
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09688092
22	P300_19829295_ChIP-Seq_ESCs_Human	2.03670742
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92475846
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.89277132
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.89194352
26	EWS_26573619_Chip-Seq_HEK293_Human	1.86618906
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.79332998
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.77440983
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75785006
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70275643
31	GATA1_22025678_ChIP-Seq_K562_Human	1.62213340
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60891806
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.60891806
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60254382
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56159857
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54267120
37	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52166451
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.50591614
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50287069
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49827487
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.48803002
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.46615604
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46369742
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44363371
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44204490
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44204490
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.43936020
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39978973
49	AR_25329375_ChIP-Seq_VCAP_Human	1.39550873
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38913940
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38561153
52	EZH2_22144423_ChIP-Seq_EOC_Human	1.36955631
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.35953131
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34871696
55	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34375260
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33646204
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31706454
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31706454
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.30353117
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29440172
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28761082
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27659233
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27346227
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27230918
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26661042
66	STAT3_23295773_ChIP-Seq_U87_Human	1.25781017
67	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.25229627
68	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23458001
69	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.22719765
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20307327
71	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19081548
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17864096
73	AR_20517297_ChIP-Seq_VCAP_Human	1.16671949
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16596660
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16113295
76	TCF4_23295773_ChIP-Seq_U87_Human	1.15961831
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14950996
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.13531399
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13291732
80	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.12397677
81	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.11000802
82	BCAT_22108803_ChIP-Seq_LS180_Human	1.09173109
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08584235
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06234076
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04815825
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.04353915
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03725847
88	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.03330914
89	GATA3_26560356_Chip-Seq_TH2_Human	1.03291495
90	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02116437
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01936869
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.00978350
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00203212
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98371815
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98031586
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97980858
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96117407
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95980910
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95462855
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95178432

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.76442589
2	MP0003136_yellow_coat_color	3.25049597
3	MP0000566_synostosis	3.06821222
4	MP0002102_abnormal_ear_morphology	2.92696931
5	MP0001529_abnormal_vocalization	2.86788781
6	MP0006072_abnormal_retinal_apoptosis	2.66199808
7	MP0009840_abnormal_foam_cell	2.35199742
8	MP0003806_abnormal_nucleotide_metabolis	2.21879934
9	MP0005084_abnormal_gallbladder_morpholo	2.14086799
10	MP0005253_abnormal_eye_physiology	2.11527918
11	MP0005551_abnormal_eye_electrophysiolog	2.11153994
12	MP0005174_abnormal_tail_pigmentation	2.09568381
13	MP0000372_irregular_coat_pigmentation	2.02607862
14	MP0009697_abnormal_copulation	1.92942340
15	MP0002938_white_spotting	1.88413869
16	MP0002095_abnormal_skin_pigmentation	1.84641686
17	MP0003252_abnormal_bile_duct	1.83239642
18	MP0008877_abnormal_DNA_methylation	1.81903779
19	MP0001984_abnormal_olfaction	1.76380087
20	MP0008058_abnormal_DNA_repair	1.72346959
21	MP0000427_abnormal_hair_cycle	1.70782221
22	MP0002282_abnormal_trachea_morphology	1.67328287
23	MP0002876_abnormal_thyroid_physiology	1.65050757
24	MP0004142_abnormal_muscle_tone	1.56062494
25	MP0005171_absent_coat_pigmentation	1.54182290
26	MP0010329_abnormal_lipoprotein_level	1.53199666
27	MP0005075_abnormal_melanosome_morpholog	1.52435728
28	MP0001764_abnormal_homeostasis	1.49520767
29	MP0005310_abnormal_salivary_gland	1.48144625
30	MP0000647_abnormal_sebaceous_gland	1.44669357
31	MP0002638_abnormal_pupillary_reflex	1.43723250
32	MP0002928_abnormal_bile_duct	1.42479778
33	MP0003011_delayed_dark_adaptation	1.37291211
34	MP0005187_abnormal_penis_morphology	1.35788823
35	MP0005671_abnormal_response_to	1.34865709
36	MP0003718_maternal_effect	1.34604227
37	MP0002653_abnormal_ependyma_morphology	1.34161404
38	MP0004145_abnormal_muscle_electrophysio	1.28798017
39	MP0003283_abnormal_digestive_organ	1.28522282
40	MP0010094_abnormal_chromosome_stability	1.25198671
41	MP0001177_atelectasis	1.20795138
42	MP0001968_abnormal_touch/_nociception	1.20669295
43	MP0003950_abnormal_plasma_membrane	1.20652956
44	MP0005410_abnormal_fertilization	1.16657860
45	MP0002254_reproductive_system_inflammat	1.15004828
46	MP0001929_abnormal_gametogenesis	1.14643374
47	MP0005645_abnormal_hypothalamus_physiol	1.14035375
48	MP0008995_early_reproductive_senescence	1.12929692
49	MP0003937_abnormal_limbs/digits/tail_de	1.11301977
50	MP0000383_abnormal_hair_follicle	1.10454016
51	MP0001485_abnormal_pinna_reflex	1.09716150
52	MP0001486_abnormal_startle_reflex	1.07044461
53	MP0005360_urolithiasis	1.05847284
54	MP0002837_dystrophic_cardiac_calcinosis	1.04460775
55	MP0002822_catalepsy	1.04393828
56	MP0003186_abnormal_redox_activity	1.03827913
57	MP0008872_abnormal_physiological_respon	1.03808419
58	MP0009046_muscle_twitch	1.03188177
59	MP0001986_abnormal_taste_sensitivity	1.02212548
60	MP0001324_abnormal_eye_pigmentation	0.99356400
61	MP0002751_abnormal_autonomic_nervous	0.98821952
62	MP0003646_muscle_fatigue	0.98589127
63	MP0001119_abnormal_female_reproductive	0.94910583
64	MP0003786_premature_aging	0.93244088
65	MP0000371_diluted_coat_color	0.92838763
66	MP0002736_abnormal_nociception_after	0.92785321
67	MP0005670_abnormal_white_adipose	0.91236066
68	MP0001835_abnormal_antigen_presentation	0.89683728
69	MP0000653_abnormal_sex_gland	0.89223779
70	MP0000613_abnormal_salivary_gland	0.88088169
71	MP0003195_calcinosis	0.87099580
72	MP0002557_abnormal_social/conspecific_i	0.86815642
73	MP0008007_abnormal_cellular_replicative	0.86782172
74	MP0002277_abnormal_respiratory_mucosa	0.86319473
75	MP0008875_abnormal_xenobiotic_pharmacok	0.85549925
76	MP0004885_abnormal_endolymph	0.85363115
77	MP0005386_behavior/neurological_phenoty	0.83294229
78	MP0004924_abnormal_behavior	0.83294229
79	MP0004133_heterotaxia	0.82652495
80	MP0002210_abnormal_sex_determination	0.81792962
81	MP0003183_abnormal_peptide_metabolism	0.80405996
82	MP0006036_abnormal_mitochondrial_physio	0.80144587
83	MP0005646_abnormal_pituitary_gland	0.79158746
84	MP0001293_anophthalmia	0.78705499
85	MP0010386_abnormal_urinary_bladder	0.78315591
86	MP0004043_abnormal_pH_regulation	0.77253083
87	MP0001800_abnormal_humoral_immune	0.77075915
88	MP0008961_abnormal_basal_metabolism	0.74523382
89	MP0003698_abnormal_male_reproductive	0.74484759
90	MP0009745_abnormal_behavioral_response	0.73349886
91	MP0006082_CNS_inflammation	0.72651257
92	MP0000631_abnormal_neuroendocrine_gland	0.72476333
93	MP0000639_abnormal_adrenal_gland	0.71873459
94	MP0000015_abnormal_ear_pigmentation	0.71722065
95	MP0003191_abnormal_cellular_cholesterol	0.69029494
96	MP0001145_abnormal_male_reproductive	0.68587347
97	MP0001963_abnormal_hearing_physiology	0.67773102
98	MP0002234_abnormal_pharynx_morphology	0.67500457
99	MP0005195_abnormal_posterior_eye	0.66570739
100	MP0005085_abnormal_gallbladder_physiolo	0.64952128

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.68690857
2	Pancreatic cysts (HP:0001737)	3.67398321
3	Hyperglycinemia (HP:0002154)	3.47460985
4	Large for gestational age (HP:0001520)	3.34692786
5	Renal cortical cysts (HP:0000803)	3.25189732
6	Abnormality of the renal cortex (HP:0011035)	3.21777576
7	Intestinal atresia (HP:0011100)	3.20601947
8	Abnormality of midbrain morphology (HP:0002418)	3.18272773
9	Molar tooth sign on MRI (HP:0002419)	3.18272773
10	Pancreatic fibrosis (HP:0100732)	3.16175650
11	Medial flaring of the eyebrow (HP:0010747)	3.11058221
12	Albinism (HP:0001022)	3.06237406
13	Abnormality of the pons (HP:0007361)	3.03833467
14	Tubulointerstitial nephritis (HP:0001970)	2.98136965
15	Congenital primary aphakia (HP:0007707)	2.96374306
16	Chronic hepatic failure (HP:0100626)	2.92578230
17	B lymphocytopenia (HP:0010976)	2.86475853
18	Hypoplasia of the pons (HP:0012110)	2.86082182
19	Abnormality of B cell number (HP:0010975)	2.85154483
20	Gait imbalance (HP:0002141)	2.80637846
21	Methylmalonic acidemia (HP:0002912)	2.74302041
22	Hypobetalipoproteinemia (HP:0003563)	2.72117396
23	Hyperglycinuria (HP:0003108)	2.67205691
24	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.65607008
25	Pendular nystagmus (HP:0012043)	2.62335837
26	Abnormality of serine family amino acid metabolism (HP:0010894)	2.58085215
27	Abnormality of glycine metabolism (HP:0010895)	2.58085215
28	Nephrogenic diabetes insipidus (HP:0009806)	2.58032111
29	Volvulus (HP:0002580)	2.54599397
30	Chronic sinusitis (HP:0011109)	2.51292799
31	Genital tract atresia (HP:0001827)	2.49110915
32	Abnormality of the labia minora (HP:0012880)	2.48940332
33	Vaginal atresia (HP:0000148)	2.48926538
34	Thyroiditis (HP:0100646)	2.45571250
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.45328478
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.45328478
37	Abolished electroretinogram (ERG) (HP:0000550)	2.40921732
38	Abnormal ciliary motility (HP:0012262)	2.39528203
39	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.38808249
40	Nephronophthisis (HP:0000090)	2.35765285
41	Abnormal respiratory motile cilium physiology (HP:0012261)	2.35641644
42	Abnormality of the renal medulla (HP:0100957)	2.32323938
43	Thyroid-stimulating hormone excess (HP:0002925)	2.29787158
44	Type II lissencephaly (HP:0007260)	2.25906186
45	Abnormality of macular pigmentation (HP:0008002)	2.23153588
46	Gastrointestinal atresia (HP:0002589)	2.22748002
47	Type I transferrin isoform profile (HP:0003642)	2.19380553
48	Brushfield spots (HP:0001088)	2.17996244
49	Short tibia (HP:0005736)	2.15515712
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15127443
51	Cystic liver disease (HP:0006706)	2.13971645
52	Methylmalonic aciduria (HP:0012120)	2.13895975
53	Attenuation of retinal blood vessels (HP:0007843)	2.13460172
54	Synostosis involving the elbow (HP:0003938)	2.12660207
55	Humeroradial synostosis (HP:0003041)	2.12660207
56	Absent/shortened dynein arms (HP:0200106)	2.12384238
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.12384238
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11696535
59	Neonatal respiratory distress (HP:0002643)	2.11576150
60	Acute necrotizing encephalopathy (HP:0006965)	2.03061519
61	Abnormality of vitamin B metabolism (HP:0004340)	2.02686062
62	Tubulointerstitial abnormality (HP:0001969)	2.00604280
63	Optic disc pallor (HP:0000543)	1.99529722
64	Broad foot (HP:0001769)	1.99513553
65	Acute encephalopathy (HP:0006846)	1.98336013
66	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.97473929
67	Congenital, generalized hypertrichosis (HP:0004540)	1.94896587
68	Severe combined immunodeficiency (HP:0004430)	1.94877741
69	Recurrent bronchitis (HP:0002837)	1.93707330
70	Decreased central vision (HP:0007663)	1.92861831
71	Progressive inability to walk (HP:0002505)	1.92477820
72	Cerebellar dysplasia (HP:0007033)	1.91423304
73	Hyperventilation (HP:0002883)	1.90924857
74	Preaxial hand polydactyly (HP:0001177)	1.90496295
75	Increased CSF lactate (HP:0002490)	1.90366152
76	Tented upper lip vermilion (HP:0010804)	1.89996295
77	Poor coordination (HP:0002370)	1.89049942
78	Progressive macrocephaly (HP:0004481)	1.88256810
79	IgG deficiency (HP:0004315)	1.87068889
80	3-Methylglutaconic aciduria (HP:0003535)	1.86577736
81	Furrowed tongue (HP:0000221)	1.85453475
82	Postaxial hand polydactyly (HP:0001162)	1.85117448
83	Congenital stationary night blindness (HP:0007642)	1.83341522
84	Agammaglobulinemia (HP:0004432)	1.83166326
85	Bronchitis (HP:0012387)	1.82877798
86	Rhinitis (HP:0012384)	1.82268042
87	Congenital hepatic fibrosis (HP:0002612)	1.81606983
88	Mitochondrial inheritance (HP:0001427)	1.80096204
89	Hypomagnesemia (HP:0002917)	1.79713171
90	Abnormality of serum amino acid levels (HP:0003112)	1.78921656
91	Short foot (HP:0001773)	1.78079374
92	Gaze-evoked nystagmus (HP:0000640)	1.77007880
93	Small hand (HP:0200055)	1.76797914
94	Birth length less than 3rd percentile (HP:0003561)	1.76284900
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.75082023
96	Male pseudohermaphroditism (HP:0000037)	1.71053682
97	IgM deficiency (HP:0002850)	1.70677186
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.69218070
99	Epiphyseal stippling (HP:0010655)	1.68690656
100	Postaxial foot polydactyly (HP:0001830)	1.67806183

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	4.95325079
2	MAP4K2	3.77566848
3	NUAK1	2.92464245
4	MUSK	2.84803997
5	FRK	2.84647664
6	VRK2	2.81181140
7	MST4	2.52558607
8	BCKDK	2.50861170
9	WEE1	2.49138936
10	VRK1	2.30453050
11	BMPR1B	2.20649128
12	AKT3	2.17508140
13	BMPR2	2.12651044
14	PIK3CG	1.94643327
15	BRSK2	1.90346629
16	WNK3	1.79356310
17	MKNK2	1.67467256
18	STK39	1.67270679
19	ADRBK2	1.55801581
20	PNCK	1.53916680
21	PLK2	1.41133337
22	CASK	1.40130982
23	NEK9	1.38661409
24	PLK4	1.37235388
25	OXSR1	1.37144097
26	ZAK	1.35749510
27	TNIK	1.34924260
28	PDK2	1.32881960
29	ERBB3	1.32878649
30	WNK4	1.30670673
31	PINK1	1.25705814
32	STK16	1.25490648
33	MAPK13	1.18604381
34	TSSK6	1.17250552
35	MKNK1	1.15457731
36	FLT3	1.14311686
37	GRK1	1.11162491
38	MARK3	1.08810493
39	ADRBK1	1.07793394
40	MAP3K12	1.04607697
41	ACVR1B	1.03422539
42	SRPK1	1.01814846
43	PBK	1.00440303
44	TAOK3	0.93889965
45	BRD4	0.93788106
46	BUB1	0.92373300
47	KIT	0.88700778
48	PTK2B	0.88247326
49	NEK1	0.87265278
50	CSF1R	0.86995542
51	FGFR2	0.85416057
52	TRIM28	0.84972746
53	TXK	0.79579527
54	CCNB1	0.77034115
55	PLK3	0.75844045
56	STK38L	0.72607968
57	MAP3K2	0.67541568
58	MAPKAPK3	0.66299658
59	TAF1	0.64264703
60	LATS1	0.61165629
61	CSNK1G1	0.61104063
62	PAK3	0.59615349
63	PRKCE	0.58408168
64	KDR	0.58200887
65	MAP3K4	0.57565682
66	STK10	0.56122361
67	PLK1	0.53395057
68	TGFBR1	0.53349998
69	TLK1	0.53178575
70	MET	0.52807473
71	GRK7	0.52642097
72	CSNK1A1L	0.51516834
73	CSNK1G3	0.50883659
74	CSNK1G2	0.50750254
75	PRKCG	0.47437486
76	PIK3CA	0.45382459
77	GRK5	0.44904798
78	TNK2	0.42549990
79	FGFR1	0.41188567
80	EIF2AK2	0.40408534
81	NLK	0.39810532
82	EIF2AK3	0.39686802
83	CDC7	0.38669463
84	NME1	0.38255855
85	IKBKE	0.37373238
86	PRKCI	0.36019022
87	MAP2K1	0.35773631
88	RPS6KA5	0.35063348
89	IGF1R	0.35015536
90	PIM2	0.34710551
91	MAPK11	0.34498318
92	OBSCN	0.34015891
93	PRKCQ	0.33409732
94	CHUK	0.32475822
95	MAPK15	0.31761972
96	ERBB4	0.30428902
97	BRSK1	0.30129314
98	TESK2	0.29428013
99	IKBKB	0.29264607
100	SYK	0.28072818

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.02567598
2	Protein export_Homo sapiens_hsa03060	2.93242708
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.88246065
4	Propanoate metabolism_Homo sapiens_hsa00640	2.61417654
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56548896
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46956404
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44154509
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.40099060
9	RNA polymerase_Homo sapiens_hsa03020	2.20631238
10	Butanoate metabolism_Homo sapiens_hsa00650	2.14374126
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.01823254
12	Primary immunodeficiency_Homo sapiens_hsa05340	1.98059148
13	Asthma_Homo sapiens_hsa05310	1.93212506
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89143753
15	Peroxisome_Homo sapiens_hsa04146	1.78459355
16	One carbon pool by folate_Homo sapiens_hsa00670	1.76167399
17	Basal transcription factors_Homo sapiens_hsa03022	1.72248697
18	Homologous recombination_Homo sapiens_hsa03440	1.70607293
19	RNA degradation_Homo sapiens_hsa03018	1.65698137
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.65439508
21	Phototransduction_Homo sapiens_hsa04744	1.61894949
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.56095525
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.55303323
24	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.54753729
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52200253
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52173042
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.49696456
28	Allograft rejection_Homo sapiens_hsa05330	1.46557405
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.40460628
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.40154805
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.39132049
32	Parkinsons disease_Homo sapiens_hsa05012	1.36374418
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35317086
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.35096343
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33360025
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31044255
37	Purine metabolism_Homo sapiens_hsa00230	1.26888362
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.26324987
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24455017
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23534003
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.20141610
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15843411
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14617201
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14344737
45	Mismatch repair_Homo sapiens_hsa03430	1.13602752
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.05833455
47	Retinol metabolism_Homo sapiens_hsa00830	1.02562001
48	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.01872478
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.98531393
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.97665192
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.95690553
52	Huntingtons disease_Homo sapiens_hsa05016	0.95197802
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95149698
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93626307
55	Sulfur metabolism_Homo sapiens_hsa00920	0.93438801
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92873209
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92602379
58	p53 signaling pathway_Homo sapiens_hsa04115	0.90725034
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88528452
60	Base excision repair_Homo sapiens_hsa03410	0.85016371
61	RNA transport_Homo sapiens_hsa03013	0.79635858
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.78902767
63	Regulation of autophagy_Homo sapiens_hsa04140	0.75745965
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75267598
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75116706
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74069438
67	Metabolic pathways_Homo sapiens_hsa01100	0.73899578
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.73889407
69	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.72889842
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.72166432
71	Nicotine addiction_Homo sapiens_hsa05033	0.71960450
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.71376475
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.70413983
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69140474
75	Alcoholism_Homo sapiens_hsa05034	0.65937267
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65663690
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64215644
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63324019
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.62069949
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61332694
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58648425
82	Alzheimers disease_Homo sapiens_hsa05010	0.58489554
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.52965850
84	Taste transduction_Homo sapiens_hsa04742	0.51449929
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49832432
86	Mineral absorption_Homo sapiens_hsa04978	0.46563641
87	Fatty acid degradation_Homo sapiens_hsa00071	0.43145288
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40838432
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38765094
90	Fatty acid elongation_Homo sapiens_hsa00062	0.38522136
91	DNA replication_Homo sapiens_hsa03030	0.38384859
92	Spliceosome_Homo sapiens_hsa03040	0.36588281
93	Olfactory transduction_Homo sapiens_hsa04740	0.35149705
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33769620
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.33374628
96	Oocyte meiosis_Homo sapiens_hsa04114	0.30643663
97	Salivary secretion_Homo sapiens_hsa04970	0.30369118
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.28976041
99	Glutathione metabolism_Homo sapiens_hsa00480	0.28744727
100	ABC transporters_Homo sapiens_hsa02010	0.27238138

METTL15P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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