METTL16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.75134651
2nuclear pore complex assembly (GO:0051292)4.59517291
3behavioral response to nicotine (GO:0035095)4.42363736
4DNA replication initiation (GO:0006270)4.37003562
5maturation of SSU-rRNA (GO:0030490)4.32312324
6DNA unwinding involved in DNA replication (GO:0006268)4.23149656
7nucleobase biosynthetic process (GO:0046112)4.13527045
8ribosome assembly (GO:0042255)4.09748593
9ribosomal large subunit biogenesis (GO:0042273)4.06627743
10mitotic metaphase plate congression (GO:0007080)4.05474053
11IMP biosynthetic process (GO:0006188)4.02827452
12negative regulation of cytosolic calcium ion concentration (GO:0051481)3.99660668
13chromatin remodeling at centromere (GO:0031055)3.98859065
14DNA replication checkpoint (GO:0000076)3.94226410
15ribosome biogenesis (GO:0042254)3.89642040
16CENP-A containing nucleosome assembly (GO:0034080)3.86809078
17purine nucleobase biosynthetic process (GO:0009113)3.85172542
18kinetochore organization (GO:0051383)3.82555413
19metaphase plate congression (GO:0051310)3.78066647
20DNA strand elongation involved in DNA replication (GO:0006271)3.77817600
21ribonucleoprotein complex biogenesis (GO:0022613)3.74929517
22protein localization to kinetochore (GO:0034501)3.74916882
23DNA replication-dependent nucleosome assembly (GO:0006335)3.73585216
24DNA replication-dependent nucleosome organization (GO:0034723)3.73585216
25mitotic nuclear envelope disassembly (GO:0007077)3.72817472
26water-soluble vitamin biosynthetic process (GO:0042364)3.70546780
27DNA strand elongation (GO:0022616)3.63375698
28DNA replication-independent nucleosome organization (GO:0034724)3.55239399
29DNA replication-independent nucleosome assembly (GO:0006336)3.55239399
30pore complex assembly (GO:0046931)3.55022453
31formation of translation preinitiation complex (GO:0001731)3.53833058
32kinetochore assembly (GO:0051382)3.52337470
33spliceosomal snRNP assembly (GO:0000387)3.52197569
34rRNA processing (GO:0006364)3.49995041
35membrane disassembly (GO:0030397)3.48621420
36nuclear envelope disassembly (GO:0051081)3.48621420
37telomere maintenance via semi-conservative replication (GO:0032201)3.47240095
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.45977264
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45977264
40ncRNA catabolic process (GO:0034661)3.42115830
41folic acid-containing compound biosynthetic process (GO:0009396)3.41866442
42regulation of DNA endoreduplication (GO:0032875)3.40031053
43rRNA metabolic process (GO:0016072)3.39816093
44histone exchange (GO:0043486)3.37798110
45IMP metabolic process (GO:0046040)3.36799111
46regulation of helicase activity (GO:0051095)3.34446066
47replication fork processing (GO:0031297)3.32803821
48attachment of spindle microtubules to kinetochore (GO:0008608)3.28339032
49regulation of centriole replication (GO:0046599)3.27428342
50regulation of hippo signaling (GO:0035330)3.26072232
51regulation of spindle organization (GO:0090224)3.25226472
52protein K6-linked ubiquitination (GO:0085020)3.25205443
53regulation of centrosome cycle (GO:0046605)3.25167828
54DNA geometric change (GO:0032392)3.25102687
55DNA duplex unwinding (GO:0032508)3.24383586
56mitotic recombination (GO:0006312)3.21548054
57telomere maintenance via telomere lengthening (GO:0010833)3.20936434
58meiotic chromosome segregation (GO:0045132)3.20531599
59establishment of chromosome localization (GO:0051303)3.20209601
60transcription elongation from RNA polymerase I promoter (GO:0006362)3.20109926
61spindle checkpoint (GO:0031577)3.19691682
62opioid receptor signaling pathway (GO:0038003)3.19622846
63mitotic sister chromatid cohesion (GO:0007064)3.19581595
64establishment of integrated proviral latency (GO:0075713)3.19062988
65regulation of posttranscriptional gene silencing (GO:0060147)3.18882373
66regulation of gene silencing by miRNA (GO:0060964)3.18882373
67regulation of gene silencing by RNA (GO:0060966)3.18882373
68telomere maintenance via recombination (GO:0000722)3.18298312
69ribosomal small subunit biogenesis (GO:0042274)3.18224363
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.16864348
71negative regulation of translation, ncRNA-mediated (GO:0040033)3.16864348
72regulation of translation, ncRNA-mediated (GO:0045974)3.16864348
73spindle assembly checkpoint (GO:0071173)3.16157167
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.15174590
75mitotic sister chromatid segregation (GO:0000070)3.15075870
76mitotic spindle checkpoint (GO:0071174)3.12667297
77spliceosomal complex assembly (GO:0000245)3.12273593
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12142685
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12142685
80negative regulation of sister chromatid segregation (GO:0033046)3.12142685
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.12142685
82negative regulation of chromosome segregation (GO:0051985)3.11924500
83termination of RNA polymerase I transcription (GO:0006363)3.11535702
84mitotic spindle assembly checkpoint (GO:0007094)3.10941668
85regulation of mitotic spindle organization (GO:0060236)3.10667941
86negative regulation of DNA-dependent DNA replication (GO:2000104)3.10117743
87protein localization to chromosome, centromeric region (GO:0071459)3.09262664
88rRNA modification (GO:0000154)3.07976190
89RNA splicing, via transesterification reactions (GO:0000375)3.07630299
90RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.06149976
91mRNA splicing, via spliceosome (GO:0000398)3.06149976
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04636635
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04591696
94behavioral response to ethanol (GO:0048149)3.04247510
95proteasome assembly (GO:0043248)3.02774329
96regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02301346
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01881036
98cell proliferation in forebrain (GO:0021846)3.01501579
99telomere maintenance via telomerase (GO:0007004)3.01178944
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00968922
101maturation of 5.8S rRNA (GO:0000460)2.99285940
102termination of RNA polymerase III transcription (GO:0006386)2.98369938
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.98369938
104sister chromatid segregation (GO:0000819)2.98266399
105translational termination (GO:0006415)2.97957675
106regulation of histone H3-K9 methylation (GO:0051570)2.96806380
107regulation of chromosome segregation (GO:0051983)2.96707625
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94595557
109transcription-coupled nucleotide-excision repair (GO:0006283)2.94545913
110somatic diversification of immunoglobulins (GO:0016445)2.94508118
111translational initiation (GO:0006413)2.94093369
112peptidyl-arginine omega-N-methylation (GO:0035247)2.93469643
113intra-S DNA damage checkpoint (GO:0031573)2.93302611
114positive regulation of chromosome segregation (GO:0051984)2.93009899
115nucleotide-excision repair, DNA gap filling (GO:0006297)2.92774892
116double-strand break repair via homologous recombination (GO:0000724)2.92628351
117recombinational repair (GO:0000725)2.90415886
118piRNA metabolic process (GO:0034587)2.88169768
119adult feeding behavior (GO:0008343)2.87356194
120sulfation (GO:0051923)2.85944647
121somatic recombination of immunoglobulin gene segments (GO:0016447)2.84809759
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83955441
123regulation of translational termination (GO:0006449)2.80745278
124lateral sprouting from an epithelium (GO:0060601)2.77834996
125response to pheromone (GO:0019236)2.75539022
126regulation of mesoderm development (GO:2000380)2.74659314
127epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69483196
128pseudouridine synthesis (GO:0001522)2.68274660
129mitochondrial RNA metabolic process (GO:0000959)2.67010323
130kidney morphogenesis (GO:0060993)2.66702570
131somite development (GO:0061053)2.65973545
132negative regulation of telomere maintenance (GO:0032205)2.65881429
133reciprocal meiotic recombination (GO:0007131)2.64282806
134reciprocal DNA recombination (GO:0035825)2.64282806
135rRNA catabolic process (GO:0016075)2.64279521
136dorsal/ventral axis specification (GO:0009950)2.64199890
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62411134
138fucose catabolic process (GO:0019317)2.58943492
139L-fucose metabolic process (GO:0042354)2.58943492
140L-fucose catabolic process (GO:0042355)2.58943492
141DNA deamination (GO:0045006)2.55888610
142cellular response to ATP (GO:0071318)2.53450191
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53035719
144kynurenine metabolic process (GO:0070189)2.52926989
145somatic diversification of immune receptors (GO:0002200)2.52432017
146somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48420108
147isotype switching (GO:0045190)2.48420108
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48420108
149regulation of mitochondrial translation (GO:0070129)2.48415011
150hindbrain development (GO:0030902)2.46741682
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.46367753
152indolalkylamine metabolic process (GO:0006586)2.45703788
153positive regulation of cAMP-mediated signaling (GO:0043950)2.44149746
154mitochondrial respiratory chain complex assembly (GO:0033108)2.43695860
155somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.41847455
156somatic cell DNA recombination (GO:0016444)2.41847455
157nonmotile primary cilium assembly (GO:0035058)2.41596697
158regulation of telomere maintenance (GO:0032204)2.40892464
159DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.40308889
160G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38737773
161neural tube formation (GO:0001841)2.38248090
162DNA strand renaturation (GO:0000733)2.36909775
163epithelial cilium movement (GO:0003351)2.36258586
164cornea development in camera-type eye (GO:0061303)2.34855121
165mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.34707242
166mitochondrial respiratory chain complex I assembly (GO:0032981)2.34707242
167NADH dehydrogenase complex assembly (GO:0010257)2.34707242
168protein complex biogenesis (GO:0070271)2.34402156
169regulation of gene silencing (GO:0060968)2.32767454
170monoubiquitinated protein deubiquitination (GO:0035520)2.31326826
171exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.31318783
172otic vesicle formation (GO:0030916)2.30586734
173DNA damage response, signal transduction resulting in transcription (GO:0042772)2.28731919
174negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.28692777
175head development (GO:0060322)2.28146155
176protein-cofactor linkage (GO:0018065)2.27483495
177mRNA cleavage (GO:0006379)2.27445599
178DNA double-strand break processing (GO:0000729)2.26648082
179DNA recombination (GO:0006310)2.24519720
180histone H4-K12 acetylation (GO:0043983)2.23731592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.10941765
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56464414
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.14849229
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.09764347
5ZNF274_21170338_ChIP-Seq_K562_Hela3.55550909
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30774492
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29727950
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08921558
9MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06172567
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.03622008
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.83115728
12VDR_22108803_ChIP-Seq_LS180_Human2.81576438
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74723489
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73464334
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72205944
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.70550850
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69965517
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68789850
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54143025
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53466493
21FUS_26573619_Chip-Seq_HEK293_Human2.51367287
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47972902
23EZH2_22144423_ChIP-Seq_EOC_Human2.47771027
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38598856
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37361082
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35790058
27VDR_23849224_ChIP-Seq_CD4+_Human2.35610882
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28465891
29XRN2_22483619_ChIP-Seq_HELA_Human2.26407892
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.17741976
31GBX2_23144817_ChIP-Seq_PC3_Human2.16990685
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16282324
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.13686256
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.10936566
35AR_21909140_ChIP-Seq_LNCAP_Human2.07573485
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04225651
37FOXP3_21729870_ChIP-Seq_TREG_Human1.99211441
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98476019
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.97281160
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97102584
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96772734
42TTF2_22483619_ChIP-Seq_HELA_Human1.93647321
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92573494
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92496103
45ELK1_19687146_ChIP-ChIP_HELA_Human1.91650070
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90309386
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88097602
48DCP1A_22483619_ChIP-Seq_HELA_Human1.87865729
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87860717
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87188909
51IGF1R_20145208_ChIP-Seq_DFB_Human1.82048575
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81980469
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77069238
54TAF15_26573619_Chip-Seq_HEK293_Human1.75818180
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71901480
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71611362
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70560828
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70354728
59GABP_19822575_ChIP-Seq_HepG2_Human1.68239440
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67922128
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66399063
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65632207
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65632207
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63337027
65CIITA_25753668_ChIP-Seq_RAJI_Human1.58762878
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57852981
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57654980
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55760721
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.55559983
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55272630
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55264138
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.51459091
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51287593
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51155788
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.50545446
76P300_19829295_ChIP-Seq_ESCs_Human1.50226680
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50053249
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48355810
79KDM5A_27292631_Chip-Seq_BREAST_Human1.46806878
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45519413
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45384412
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.44223598
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43990045
84CBP_20019798_ChIP-Seq_JUKART_Human1.43990045
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.43880985
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43499584
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42745942
88AR_21572438_ChIP-Seq_LNCaP_Human1.36573566
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33621310
90RNF2_27304074_Chip-Seq_NSC_Mouse1.32377919
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30623626
92STAT3_23295773_ChIP-Seq_U87_Human1.29160001
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24135752
94ER_23166858_ChIP-Seq_MCF-7_Human1.22106073
95TCF4_23295773_ChIP-Seq_U87_Human1.21759904
96MYC_18940864_ChIP-ChIP_HL60_Human1.21549301
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.19343606
98TP53_22573176_ChIP-Seq_HFKS_Human1.18403315
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17108743
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16758408
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16453676
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14768732
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14476801
104BCAT_22108803_ChIP-Seq_LS180_Human1.13561423
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13346123
106* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11268303
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10701010
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.08623683
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08399417
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08265224
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08132391
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06836099
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06820293
114LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04908183
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04427282
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.04396795
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03809781
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02848305
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02524973
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02524973
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02524973
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99504064
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98634797
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98560155
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98450908
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98278279
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98164796
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97111433
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96838120
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.96297068
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96214809
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94218465
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94009431
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93928804
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93757799
136TFEB_21752829_ChIP-Seq_HELA_Human0.93618466
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92355218
138NANOG_19829295_ChIP-Seq_ESCs_Human0.92230040
139SOX2_19829295_ChIP-Seq_ESCs_Human0.92230040
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92148900
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91861736
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91729263
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.91460798
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91389482
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91287571
146TCF4_22108803_ChIP-Seq_LS180_Human0.90151403
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.90130676
148AR_25329375_ChIP-Seq_VCAP_Human0.89885082
149DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89825791
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89228645
151HOXB7_26014856_ChIP-Seq_BT474_Human0.88937032
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87847631
153SMAD4_21799915_ChIP-Seq_A2780_Human0.87554952
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.87031451
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.85507273
156EWS_26573619_Chip-Seq_HEK293_Human0.85402490
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.84136211
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83700614
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82451349
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79014560
161IRF1_19129219_ChIP-ChIP_H3396_Human0.77540730
162MYC_22102868_ChIP-Seq_BL_Human0.76578491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.79841129
2MP0003693_abnormal_embryo_hatching4.51341661
3MP0003111_abnormal_nucleus_morphology4.46597908
4MP0008057_abnormal_DNA_replication4.33959561
5MP0008058_abnormal_DNA_repair3.97785518
6MP0004957_abnormal_blastocyst_morpholog3.89937456
7MP0003077_abnormal_cell_cycle3.59769306
8MP0003646_muscle_fatigue3.24117290
9MP0008877_abnormal_DNA_methylation3.22251589
10MP0003123_paternal_imprinting3.09119479
11MP0008932_abnormal_embryonic_tissue2.55358972
12MP0008007_abnormal_cellular_replicative2.38368462
13MP0003121_genomic_imprinting2.29285789
14MP0009780_abnormal_chondrocyte_physiolo2.22583906
15MP0002876_abnormal_thyroid_physiology2.15161041
16MP0001968_abnormal_touch/_nociception2.14757001
17MP0003786_premature_aging2.13549188
18MP0001730_embryonic_growth_arrest2.11443734
19MP0000350_abnormal_cell_proliferation2.07212592
20MP0006292_abnormal_olfactory_placode2.04619244
21MP0003890_abnormal_embryonic-extraembry1.94477881
22MP0005646_abnormal_pituitary_gland1.90988546
23MP0001485_abnormal_pinna_reflex1.88428697
24MP0003941_abnormal_skin_development1.85945173
25MP0010307_abnormal_tumor_latency1.74396123
26MP0000537_abnormal_urethra_morphology1.70986813
27MP0001672_abnormal_embryogenesis/_devel1.68904490
28MP0005380_embryogenesis_phenotype1.68904490
29MP0005551_abnormal_eye_electrophysiolog1.67297792
30MP0002084_abnormal_developmental_patter1.64740198
31MP0002085_abnormal_embryonic_tissue1.61900535
32MP0001697_abnormal_embryo_size1.61270823
33MP0004197_abnormal_fetal_growth/weight/1.58145262
34MP0002210_abnormal_sex_determination1.57400161
35MP0002396_abnormal_hematopoietic_system1.52798065
36MP0003787_abnormal_imprinting1.50676912
37MP0003937_abnormal_limbs/digits/tail_de1.50483406
38MP0003984_embryonic_growth_retardation1.47515626
39MP0002088_abnormal_embryonic_growth/wei1.44387830
40MP0004133_heterotaxia1.43287443
41MP0003567_abnormal_fetal_cardiomyocyte1.43013786
42MP0002080_prenatal_lethality1.43003365
43MP0001293_anophthalmia1.42885130
44MP0003136_yellow_coat_color1.36884304
45MP0001188_hyperpigmentation1.36671144
46MP0008872_abnormal_physiological_respon1.36114436
47MP0010352_gastrointestinal_tract_polyps1.33480026
48MP0001145_abnormal_male_reproductive1.33373755
49MP0000566_synostosis1.33087963
50MP0009053_abnormal_anal_canal1.32732259
51MP0004742_abnormal_vestibular_system1.32107554
52MP0003718_maternal_effect1.31690547
53MP0004885_abnormal_endolymph1.31236373
54MP0002736_abnormal_nociception_after1.30244405
55MP0005645_abnormal_hypothalamus_physiol1.29399576
56MP0002160_abnormal_reproductive_system1.28364210
57MP0002234_abnormal_pharynx_morphology1.27936863
58MP0001286_abnormal_eye_development1.26700803
59MP0002086_abnormal_extraembryonic_tissu1.23790935
60MP0003119_abnormal_digestive_system1.20628521
61MP0000313_abnormal_cell_death1.17731471
62MP0003195_calcinosis1.17485205
63MP0000383_abnormal_hair_follicle1.16066226
64MP0000653_abnormal_sex_gland1.15589780
65MP0001929_abnormal_gametogenesis1.15146422
66MP0008789_abnormal_olfactory_epithelium1.13436971
67MP0002837_dystrophic_cardiac_calcinosis1.11147501
68MP0001986_abnormal_taste_sensitivity1.11108531
69MP0003315_abnormal_perineum_morphology1.10456005
70MP0002272_abnormal_nervous_system1.08555037
71MP0003283_abnormal_digestive_organ1.07062481
72MP0002111_abnormal_tail_morphology1.06379790
73MP0009745_abnormal_behavioral_response1.06181052
74MP0005253_abnormal_eye_physiology1.03824255
75MP0006035_abnormal_mitochondrial_morpho1.03529768
76MP0002249_abnormal_larynx_morphology1.03162998
77MP0004145_abnormal_muscle_electrophysio1.01513967
78MP0004142_abnormal_muscle_tone1.01378724
79MP0002277_abnormal_respiratory_mucosa1.00472008
80MP0006072_abnormal_retinal_apoptosis0.99748152
81MP0005389_reproductive_system_phenotype0.99173348
82MP0000428_abnormal_craniofacial_morphol0.99002446
83MP0002735_abnormal_chemical_nociception0.98186187
84MP0003861_abnormal_nervous_system0.96725300
85MP0009046_muscle_twitch0.93874875
86MP0000490_abnormal_crypts_of0.93781968
87MP0005076_abnormal_cell_differentiation0.93239207
88MP0002019_abnormal_tumor_incidence0.91609498
89MP0010030_abnormal_orbit_morphology0.90933466
90MP0009379_abnormal_foot_pigmentation0.89957427
91MP0000049_abnormal_middle_ear0.89245719
92MP0009703_decreased_birth_body0.88977877
93MP0000432_abnormal_head_morphology0.88255361
94MP0003938_abnormal_ear_development0.86955122
95MP0005499_abnormal_olfactory_system0.85043996
96MP0005394_taste/olfaction_phenotype0.85043996
97MP0002254_reproductive_system_inflammat0.84612517
98MP0000569_abnormal_digit_pigmentation0.84227205
99MP0002697_abnormal_eye_size0.83646919
100MP0003755_abnormal_palate_morphology0.83332579
101MP0002938_white_spotting0.81599931
102MP0001119_abnormal_female_reproductive0.81094699
103MP0005195_abnormal_posterior_eye0.80518574
104MP0002751_abnormal_autonomic_nervous0.80064930
105MP0002557_abnormal_social/conspecific_i0.79894960
106MP0005367_renal/urinary_system_phenotyp0.79854321
107MP0000516_abnormal_urinary_system0.79854321
108MP0001529_abnormal_vocalization0.79041479
109MP0003698_abnormal_male_reproductive0.78946230
110MP0004808_abnormal_hematopoietic_stem0.78707546
111MP0009250_abnormal_appendicular_skeleto0.78625562
112MP0003942_abnormal_urinary_system0.78540419
113MP0009672_abnormal_birth_weight0.77241346
114MP0000427_abnormal_hair_cycle0.77094425
115MP0000026_abnormal_inner_ear0.76170406
116MP0002928_abnormal_bile_duct0.75608074
117MP0001501_abnormal_sleep_pattern0.75413004
118MP0002102_abnormal_ear_morphology0.73716887
119MP0004134_abnormal_chest_morphology0.72507738
120MP0002653_abnormal_ependyma_morphology0.72358434
121MP0000703_abnormal_thymus_morphology0.72294768
122MP0000778_abnormal_nervous_system0.72071961
123MP0005377_hearing/vestibular/ear_phenot0.71508175
124MP0003878_abnormal_ear_physiology0.71508175
125MP0002114_abnormal_axial_skeleton0.71475105
126MP0005384_cellular_phenotype0.71263205
127MP0004130_abnormal_muscle_cell0.71122192
128MP0000358_abnormal_cell_content/0.70286008
129MP0008995_early_reproductive_senescence0.70191408
130MP0002092_abnormal_eye_morphology0.69970035
131MP0001919_abnormal_reproductive_system0.68607736
132MP0003122_maternal_imprinting0.67530492
133MP0005391_vision/eye_phenotype0.67008266
134MP0003936_abnormal_reproductive_system0.65950520
135MP0002095_abnormal_skin_pigmentation0.64346678
136MP0000015_abnormal_ear_pigmentation0.64161599
137MP0003935_abnormal_craniofacial_develop0.63161740
138MP0000631_abnormal_neuroendocrine_gland0.62951943
139MP0002177_abnormal_outer_ear0.62521492
140MP0002116_abnormal_craniofacial_bone0.60546878
141MP0002081_perinatal_lethality0.60116313
142MP0002233_abnormal_nose_morphology0.59656076
143MP0005409_darkened_coat_color0.56994412
144MP0002075_abnormal_coat/hair_pigmentati0.56802913
145MP0002161_abnormal_fertility/fecundity0.55826415

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.30609361
2Chromsome breakage (HP:0040012)4.29718413
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08852541
4Abnormality of the labia minora (HP:0012880)3.78695815
5Thyroid-stimulating hormone excess (HP:0002925)3.67729503
6Reticulocytopenia (HP:0001896)3.60789020
7Medulloblastoma (HP:0002885)3.38427672
8Pancreatic cysts (HP:0001737)3.30649563
9Abnormality of chromosome stability (HP:0003220)3.29803904
10Abnormality of the preputium (HP:0100587)3.22780025
11Pancreatic fibrosis (HP:0100732)3.19496691
12Colon cancer (HP:0003003)3.17927073
13Pendular nystagmus (HP:0012043)3.17129007
14Ependymoma (HP:0002888)3.15129967
15Patellar aplasia (HP:0006443)3.12850441
16Breast hypoplasia (HP:0003187)3.11371068
17Meckel diverticulum (HP:0002245)3.10370749
18Supernumerary spleens (HP:0009799)3.08968956
19True hermaphroditism (HP:0010459)3.03702462
20Abnormality of the ileum (HP:0001549)2.91347012
21Aplasia/Hypoplasia of the patella (HP:0006498)2.90159997
22Molar tooth sign on MRI (HP:0002419)2.88903729
23Abnormality of midbrain morphology (HP:0002418)2.88903729
24Selective tooth agenesis (HP:0001592)2.83840350
25Intestinal atresia (HP:0011100)2.83828890
26Nephronophthisis (HP:0000090)2.81476659
27Absent radius (HP:0003974)2.80266233
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.78896519
29Abnormality of the proximal phalanges of the hand (HP:0009834)2.77723052
30Impulsivity (HP:0100710)2.72333363
31Agnosia (HP:0010524)2.70533920
32Gaze-evoked nystagmus (HP:0000640)2.60826593
33Chronic hepatic failure (HP:0100626)2.60350262
34Absent forearm bone (HP:0003953)2.60077306
35Aplasia involving forearm bones (HP:0009822)2.60077306
36Carpal bone hypoplasia (HP:0001498)2.59707285
37Oral leukoplakia (HP:0002745)2.54278568
38Proximal placement of thumb (HP:0009623)2.54266311
39Rhabdomyosarcoma (HP:0002859)2.53469959
40Gastrointestinal atresia (HP:0002589)2.53046099
41Abnormal number of incisors (HP:0011064)2.49462513
42Duplicated collecting system (HP:0000081)2.49070140
43Congenital stationary night blindness (HP:0007642)2.47644632
44Absent thumb (HP:0009777)2.47339698
45Genetic anticipation (HP:0003743)2.45342916
46Cerebral hypomyelination (HP:0006808)2.44581761
47Rough bone trabeculation (HP:0100670)2.44362381
48Horseshoe kidney (HP:0000085)2.40122897
49Deviation of the thumb (HP:0009603)2.39287921
50Methylmalonic acidemia (HP:0002912)2.39010272
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.38556434
52Type II lissencephaly (HP:0007260)2.34170147
53Glioma (HP:0009733)2.34008549
54Aplasia/hypoplasia of the humerus (HP:0006507)2.33619575
55Small intestinal stenosis (HP:0012848)2.32107012
56Duodenal stenosis (HP:0100867)2.32107012
57Abnormality of the renal cortex (HP:0011035)2.29662366
5811 pairs of ribs (HP:0000878)2.28644156
59Abnormality of the renal medulla (HP:0100957)2.27796970
60Increased nuchal translucency (HP:0010880)2.26768983
61Sloping forehead (HP:0000340)2.26720728
62Neoplasm of the pancreas (HP:0002894)2.26487117
63Biliary tract neoplasm (HP:0100574)2.25544196
64Abnormal lung lobation (HP:0002101)2.24269704
65Abnormality of cells of the erythroid lineage (HP:0012130)2.23758424
66Hypoplasia of the pons (HP:0012110)2.23644586
67Tubular atrophy (HP:0000092)2.23350600
68Macrocytic anemia (HP:0001972)2.22379168
69Abnormality of the astrocytes (HP:0100707)2.21561755
70Astrocytoma (HP:0009592)2.21561755
71Septo-optic dysplasia (HP:0100842)2.21215661
72Abnormality of the carotid arteries (HP:0005344)2.19692808
73Myelodysplasia (HP:0002863)2.19592600
74Ectopic kidney (HP:0000086)2.18790204
75Optic nerve hypoplasia (HP:0000609)2.18332738
76Esophageal atresia (HP:0002032)2.17984855
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17607817
78Facial cleft (HP:0002006)2.17128527
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15387750
80Abnormality of alanine metabolism (HP:0010916)2.15387750
81Hyperalaninemia (HP:0003348)2.15387750
82Abnormality of the renal collecting system (HP:0004742)2.15012445
83Bone marrow hypocellularity (HP:0005528)2.14733982
84Triphalangeal thumb (HP:0001199)2.13147086
85Neoplasm of the oral cavity (HP:0100649)2.11451628
86Volvulus (HP:0002580)2.09745866
87Premature graying of hair (HP:0002216)2.09412998
88Short thumb (HP:0009778)2.09153764
89Large for gestational age (HP:0001520)2.07568575
90Sparse lateral eyebrow (HP:0005338)2.07066775
91Hyperglycinemia (HP:0002154)2.05501600
92Abnormality of the pons (HP:0007361)2.03182383
93Abnormality of the columella (HP:0009929)2.02940717
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02910830
95Tracheoesophageal fistula (HP:0002575)2.00831383
96Pelvic girdle muscle weakness (HP:0003749)1.99366401
97Atresia of the external auditory canal (HP:0000413)1.98486290
98Pallor (HP:0000980)1.98085215
99Abnormality of the aortic arch (HP:0012303)1.98029795
100Cystic liver disease (HP:0006706)1.97652562
101Abnormality of the duodenum (HP:0002246)1.96787830
102Progressive cerebellar ataxia (HP:0002073)1.96668505
103Sclerocornea (HP:0000647)1.96372888
104Abnormal number of erythroid precursors (HP:0012131)1.95571651
105Bilateral microphthalmos (HP:0007633)1.94415320
106Attenuation of retinal blood vessels (HP:0007843)1.93792023
107Abnormal rod and cone electroretinograms (HP:0008323)1.93667469
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.93645164
109Nephroblastoma (Wilms tumor) (HP:0002667)1.92917410
110Basal cell carcinoma (HP:0002671)1.92537342
111Rib fusion (HP:0000902)1.92521183
112Short humerus (HP:0005792)1.91757326
113Neoplasm of striated muscle (HP:0009728)1.90959640
114Renal cortical cysts (HP:0000803)1.89877003
115Progressive inability to walk (HP:0002505)1.89825092
116Degeneration of anterior horn cells (HP:0002398)1.88355259
117Abnormality of the anterior horn cell (HP:0006802)1.88355259
118Supernumerary bones of the axial skeleton (HP:0009144)1.87590799
119Furrowed tongue (HP:0000221)1.85400044
120Anencephaly (HP:0002323)1.85201955
121Methylmalonic aciduria (HP:0012120)1.84945680
122Microvesicular hepatic steatosis (HP:0001414)1.83987326
123Prominent nose (HP:0000448)1.82996104
124Agitation (HP:0000713)1.82864147
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82790854
126Abnormal trabecular bone morphology (HP:0100671)1.82728964
127Aplastic anemia (HP:0001915)1.81800338
128Abnormality of the nasal septum (HP:0000419)1.81186887
129Increased corneal curvature (HP:0100692)1.81056367
130Keratoconus (HP:0000563)1.81056367
131Lissencephaly (HP:0001339)1.80366143
132Preaxial hand polydactyly (HP:0001177)1.80130125
133Broad-based gait (HP:0002136)1.79904309
134Squamous cell carcinoma (HP:0002860)1.79317630
135Abnormality of DNA repair (HP:0003254)1.78811020
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.78782435
137Embryonal renal neoplasm (HP:0011794)1.78176252
138Shoulder girdle muscle weakness (HP:0003547)1.77756452
139Dandy-Walker malformation (HP:0001305)1.76928165
140Aplasia/hypoplasia of the uterus (HP:0008684)1.75471538
141Abnormal biliary tract physiology (HP:0012439)1.74638132
142Bile duct proliferation (HP:0001408)1.74638132
143Facial hemangioma (HP:0000329)1.74246083
144Abolished electroretinogram (ERG) (HP:0000550)1.73931202
145Short hallux (HP:0010109)1.73463593
146High anterior hairline (HP:0009890)1.73213538
147Cerebellar dysplasia (HP:0007033)1.72593892
148Abnormality of glycine metabolism (HP:0010895)1.71994077
149Abnormality of serine family amino acid metabolism (HP:0010894)1.71994077
150Small hand (HP:0200055)1.71559499
151Abnormal spermatogenesis (HP:0008669)1.71187602
152Hyperventilation (HP:0002883)1.70542659
153Cellular immunodeficiency (HP:0005374)1.68911620
154Neoplasm of the colon (HP:0100273)1.67808993
155Missing ribs (HP:0000921)1.66870751
156Clubbing of toes (HP:0100760)1.64475062
157Premature ovarian failure (HP:0008209)1.64389238
158Breast aplasia (HP:0100783)1.64334116
159Aplasia/Hypoplasia of the earlobes (HP:0009906)1.64281646
160Supernumerary ribs (HP:0005815)1.63418401
161Cafe-au-lait spot (HP:0000957)1.61907157
162Asplenia (HP:0001746)1.61740387
163Secondary amenorrhea (HP:0000869)1.60545072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.62443544
2CDC73.96917558
3SRPK13.79769556
4WEE13.71023895
5ADRBK23.65893994
6BUB13.59634414
7TLK13.26617243
8TSSK63.09449723
9EIF2AK12.81223707
10PLK42.68604526
11MKNK12.60671287
12TTK2.57030708
13MKNK22.52961086
14CDK122.35505925
15NUAK12.29304219
16NEK22.19428830
17PLK32.18491127
18PNCK2.16247036
19PINK12.16215370
20ZAK2.07546520
21GRK12.07317912
22PLK12.04996623
23EPHA22.02408835
24TAF12.00455909
25WNK41.97108350
26STK161.96889991
27EIF2AK31.95043448
28VRK21.85741122
29ATR1.85495445
30NEK11.79626352
31DYRK31.74121602
32VRK11.73320970
33AURKB1.71588833
34CHEK21.65315288
35INSRR1.64961147
36CDK71.55025726
37TAOK31.54497287
38BRSK21.53951653
39PASK1.50152858
40BRD41.49459942
41CHEK11.49098028
42STK391.40081143
43MAP4K21.33559752
44AURKA1.33259355
45TXK1.33115769
46FGFR21.32236375
47RPS6KB21.25931001
48MAP3K41.24956925
49NME21.22205629
50MAPK131.21762262
51ATM1.21406776
52CAMK1D1.21017348
53CAMK1G1.12921794
54AKT31.11277153
55TESK21.09881667
56ACVR1B1.08152555
57CDK41.07527131
58BRSK11.06813595
59ALK1.02151910
60CDK21.01922503
61NLK1.01356891
62MAP3K80.98480131
63PRKCG0.97244119
64PBK0.96860097
65CCNB10.96712838
66EIF2AK20.95265741
67RPS6KA40.91431735
68STK40.88876136
69CDK10.87301241
70CSNK2A20.87226337
71ERBB30.84383230
72RPS6KA50.83331610
73NEK90.82130985
74MAPKAPK50.81499175
75YES10.78199215
76PRKCE0.75552584
77MAPK150.74486024
78NME10.73821794
79ADRBK10.72426110
80MAP3K100.71556706
81CSNK1G10.70802477
82STK38L0.69928951
83CSNK1E0.69826892
84MELK0.67884623
85CSNK2A10.65103058
86PRKDC0.62714991
87IRAK30.61962403
88CDK80.61213619
89STK30.61173150
90STK100.60766876
91PLK20.58245790
92OXSR10.57223118
93CSNK1D0.57072099
94CDK30.55410077
95PRKCI0.55286124
96CLK10.55071408
97PIM10.52208377
98CDK60.50382024
99MAP2K70.49150801
100IRAK10.48747086
101SCYL20.48480888
102RPS6KA60.46540647
103SGK20.45600975
104MAPK140.44222797
105PRKD20.43602847
106BRAF0.42016021
107PRKAA10.41356247
108WNK30.41230092
109PAK10.40635630
110TGFBR10.40489525
111AKT20.40082063
112TYRO30.38986882
113CASK0.38509329
114GSK3B0.38456908
115FGFR10.38066828
116SGK10.37925381
117CSNK1A10.37628593
118MTOR0.36439744
119MAP2K20.35983037
120MST40.34312860
121PRKCQ0.34021020
122PAK40.33994519
123TNIK0.31622868
124DYRK20.31025307
125BCR0.30919097
126RPS6KB10.27242225
127BMPR1B0.27062700
128PDK30.26221421
129PDK40.26221421
130MAPK100.25641759
131STK240.25375052
132MAP3K50.25347903
133ERBB40.24492173
134AKT10.24259434
135MAPK90.24127155
136LATS10.22602526
137CSNK1G30.22459524
138EEF2K0.21080095
139LATS20.19870487
140MAPK10.18144855

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.54749416
2DNA replication_Homo sapiens_hsa030304.13345676
3Mismatch repair_Homo sapiens_hsa034303.99852258
4RNA polymerase_Homo sapiens_hsa030203.80444602
5Spliceosome_Homo sapiens_hsa030403.58017663
6RNA transport_Homo sapiens_hsa030133.48855490
7Homologous recombination_Homo sapiens_hsa034403.12995080
8Ribosome_Homo sapiens_hsa030103.08842890
9Proteasome_Homo sapiens_hsa030502.91840321
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85344043
11Fanconi anemia pathway_Homo sapiens_hsa034602.83876716
12Nucleotide excision repair_Homo sapiens_hsa034202.81720292
13One carbon pool by folate_Homo sapiens_hsa006702.74785043
14Non-homologous end-joining_Homo sapiens_hsa034502.72278750
15Cell cycle_Homo sapiens_hsa041102.67467510
16Base excision repair_Homo sapiens_hsa034102.57226306
17Basal transcription factors_Homo sapiens_hsa030222.41921389
18Pyrimidine metabolism_Homo sapiens_hsa002402.37359259
19mRNA surveillance pathway_Homo sapiens_hsa030152.21837481
20RNA degradation_Homo sapiens_hsa030182.12450442
21Systemic lupus erythematosus_Homo sapiens_hsa053221.72315017
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70708152
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.53859555
24p53 signaling pathway_Homo sapiens_hsa041151.53129250
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49597118
26Linoleic acid metabolism_Homo sapiens_hsa005911.49039481
27Purine metabolism_Homo sapiens_hsa002301.41273521
28Nicotine addiction_Homo sapiens_hsa050331.40104866
29Taste transduction_Homo sapiens_hsa047421.38067966
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32348042
31Butanoate metabolism_Homo sapiens_hsa006501.30415385
32Nitrogen metabolism_Homo sapiens_hsa009101.30073608
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26103311
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25298190
35Epstein-Barr virus infection_Homo sapiens_hsa051691.22219929
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20072474
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15721663
38Propanoate metabolism_Homo sapiens_hsa006401.11949480
39Tryptophan metabolism_Homo sapiens_hsa003801.09287524
40Viral carcinogenesis_Homo sapiens_hsa052031.07081271
41Olfactory transduction_Homo sapiens_hsa047401.04976692
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04622811
43Oocyte meiosis_Homo sapiens_hsa041141.03200716
44Alcoholism_Homo sapiens_hsa050340.98836282
45Dorso-ventral axis formation_Homo sapiens_hsa043200.95691117
46Vitamin digestion and absorption_Homo sapiens_hsa049770.94276784
47Protein export_Homo sapiens_hsa030600.90657112
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89787721
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88767145
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87461237
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86142830
52ABC transporters_Homo sapiens_hsa020100.84859249
53Basal cell carcinoma_Homo sapiens_hsa052170.75493730
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.74709355
55HTLV-I infection_Homo sapiens_hsa051660.72669069
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71655562
57Huntingtons disease_Homo sapiens_hsa050160.71160004
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69690908
59Herpes simplex infection_Homo sapiens_hsa051680.69638785
60Fatty acid biosynthesis_Homo sapiens_hsa000610.69175754
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67903784
62Vitamin B6 metabolism_Homo sapiens_hsa007500.67879078
63Morphine addiction_Homo sapiens_hsa050320.67131151
64MicroRNAs in cancer_Homo sapiens_hsa052060.67028538
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65757287
66Hippo signaling pathway_Homo sapiens_hsa043900.62584094
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62430481
68TGF-beta signaling pathway_Homo sapiens_hsa043500.61206931
69Glycerolipid metabolism_Homo sapiens_hsa005610.61202300
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.60487469
71Antigen processing and presentation_Homo sapiens_hsa046120.60070381
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59593261
73Caffeine metabolism_Homo sapiens_hsa002320.59535119
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.57812217
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57743345
76Selenocompound metabolism_Homo sapiens_hsa004500.56961631
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56940168
78Thyroid cancer_Homo sapiens_hsa052160.56821942
79Hedgehog signaling pathway_Homo sapiens_hsa043400.50124271
80Retinol metabolism_Homo sapiens_hsa008300.48069480
81Cardiac muscle contraction_Homo sapiens_hsa042600.47164340
82Type I diabetes mellitus_Homo sapiens_hsa049400.44765962
83Calcium signaling pathway_Homo sapiens_hsa040200.43690449
84Wnt signaling pathway_Homo sapiens_hsa043100.42877473
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42552390
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41881992
87Phototransduction_Homo sapiens_hsa047440.41561809
88Parkinsons disease_Homo sapiens_hsa050120.40700929
89Steroid biosynthesis_Homo sapiens_hsa001000.40472777
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40283462
91Small cell lung cancer_Homo sapiens_hsa052220.39105120
92Glutamatergic synapse_Homo sapiens_hsa047240.38275597
93Biosynthesis of amino acids_Homo sapiens_hsa012300.37867293
94Chemical carcinogenesis_Homo sapiens_hsa052040.37428964
95Serotonergic synapse_Homo sapiens_hsa047260.36681499
96Ovarian steroidogenesis_Homo sapiens_hsa049130.36533424
97Pyruvate metabolism_Homo sapiens_hsa006200.35603691
98Pentose phosphate pathway_Homo sapiens_hsa000300.35288869
99Insulin secretion_Homo sapiens_hsa049110.34137816
100Oxidative phosphorylation_Homo sapiens_hsa001900.34084017
101Sulfur metabolism_Homo sapiens_hsa009200.33612748
102Notch signaling pathway_Homo sapiens_hsa043300.33542419
103Colorectal cancer_Homo sapiens_hsa052100.32590534
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32482358
105Long-term depression_Homo sapiens_hsa047300.31287246
106Folate biosynthesis_Homo sapiens_hsa007900.29599887
107Alzheimers disease_Homo sapiens_hsa050100.29476079
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28705777
109beta-Alanine metabolism_Homo sapiens_hsa004100.28449179
110Pathways in cancer_Homo sapiens_hsa052000.27404900
111Prostate cancer_Homo sapiens_hsa052150.27312849
112Type II diabetes mellitus_Homo sapiens_hsa049300.26189928
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21687217
114N-Glycan biosynthesis_Homo sapiens_hsa005100.20912773
115Tight junction_Homo sapiens_hsa045300.20281999
116Melanoma_Homo sapiens_hsa052180.19748916
117Legionellosis_Homo sapiens_hsa051340.17316092
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.16636145
119Apoptosis_Homo sapiens_hsa042100.15377309
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.14405274
121Metabolic pathways_Homo sapiens_hsa011000.13760382
122Glutathione metabolism_Homo sapiens_hsa004800.13424167
123Regulation of autophagy_Homo sapiens_hsa041400.12402699
124Lysine degradation_Homo sapiens_hsa003100.12320003
125Primary immunodeficiency_Homo sapiens_hsa053400.12006079
126Hematopoietic cell lineage_Homo sapiens_hsa046400.11168544
127Hepatitis B_Homo sapiens_hsa051610.10253411
128HIF-1 signaling pathway_Homo sapiens_hsa040660.10083419
129Sulfur relay system_Homo sapiens_hsa041220.08906455
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08885166
131Adherens junction_Homo sapiens_hsa045200.08733842
132Autoimmune thyroid disease_Homo sapiens_hsa053200.08303365
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07646156
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07614053
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06219641
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06138290
137mTOR signaling pathway_Homo sapiens_hsa041500.05157385
138Arachidonic acid metabolism_Homo sapiens_hsa005900.04991746
139Graft-versus-host disease_Homo sapiens_hsa053320.04770537
140Ether lipid metabolism_Homo sapiens_hsa005650.04113533
141T cell receptor signaling pathway_Homo sapiens_hsa046600.04078586
142Measles_Homo sapiens_hsa051620.03465397
143Viral myocarditis_Homo sapiens_hsa054160.02909707
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.02888568
145FoxO signaling pathway_Homo sapiens_hsa040680.02339465
146Allograft rejection_Homo sapiens_hsa053300.00312284
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0040947

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