METTL17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of nuclear cell cycle DNA replication (GO:0033262)4.65698097
2DNA strand elongation involved in DNA replication (GO:0006271)4.39407769
3DNA strand elongation (GO:0022616)4.15101780
4ribosomal small subunit assembly (GO:0000028)3.91572183
5iron-sulfur cluster assembly (GO:0016226)3.89375640
6metallo-sulfur cluster assembly (GO:0031163)3.89375640
7telomere maintenance via recombination (GO:0000722)3.88194468
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.83654000
9protein complex biogenesis (GO:0070271)3.61645121
10mitotic recombination (GO:0006312)3.56051432
11nucleotide-excision repair, DNA gap filling (GO:0006297)3.53817128
12transcription elongation from RNA polymerase III promoter (GO:0006385)3.52850195
13termination of RNA polymerase III transcription (GO:0006386)3.52850195
14DNA deamination (GO:0045006)3.49685278
15DNA replication checkpoint (GO:0000076)3.49224872
16respiratory chain complex IV assembly (GO:0008535)3.48495609
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.46695379
18NADH dehydrogenase complex assembly (GO:0010257)3.46695379
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46695379
20pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43762538
21DNA replication-dependent nucleosome assembly (GO:0006335)3.40406032
22DNA replication-dependent nucleosome organization (GO:0034723)3.40406032
23proteasome assembly (GO:0043248)3.39017871
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37242122
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37242122
26protein-cofactor linkage (GO:0018065)3.33878384
27tRNA methylation (GO:0030488)3.33854342
28nucleobase biosynthetic process (GO:0046112)3.31679142
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30804018
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30669557
31purine nucleobase biosynthetic process (GO:0009113)3.30640567
32DNA replication initiation (GO:0006270)3.29909986
33mitochondrial respiratory chain complex assembly (GO:0033108)3.26631651
34histone H2A acetylation (GO:0043968)3.23546987
35dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.20907916
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.17436195
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17436195
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.13893182
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.12769264
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10911542
41ATP synthesis coupled proton transport (GO:0015986)3.10911542
42mannosylation (GO:0097502)3.09580459
43cytochrome complex assembly (GO:0017004)3.07729701
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05551432
45intra-S DNA damage checkpoint (GO:0031573)3.01163489
46endosome to pigment granule transport (GO:0043485)3.01090357
47endosome to melanosome transport (GO:0035646)3.01090357
48superoxide anion generation (GO:0042554)3.00104876
49transcription-coupled nucleotide-excision repair (GO:0006283)2.99120961
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97116160
51mitochondrial RNA metabolic process (GO:0000959)2.94969949
52deoxyribose phosphate biosynthetic process (GO:0046385)2.94843099
532-deoxyribonucleotide biosynthetic process (GO:0009265)2.94843099
547-methylguanosine mRNA capping (GO:0006370)2.94758233
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93939556
56negative regulation of ligase activity (GO:0051352)2.93939556
57RNA capping (GO:0036260)2.91643889
587-methylguanosine RNA capping (GO:0009452)2.91643889
59maturation of SSU-rRNA (GO:0030490)2.89846537
60oxidative phosphorylation (GO:0006119)2.89330956
61rRNA modification (GO:0000154)2.89166988
62negative regulation of DNA-dependent DNA replication (GO:2000104)2.88528339
63base-excision repair, AP site formation (GO:0006285)2.88506107
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85977616
65tRNA processing (GO:0008033)2.84319494
66GMP metabolic process (GO:0046037)2.83789824
67DNA catabolic process, exonucleolytic (GO:0000738)2.82689698
68chromatin remodeling at centromere (GO:0031055)2.81623200
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81597248
70tRNA modification (GO:0006400)2.81270136
71tRNA metabolic process (GO:0006399)2.81009436
72peptidyl-histidine modification (GO:0018202)2.80926497
73maturation of 5.8S rRNA (GO:0000460)2.80558193
74negative regulation of telomere maintenance (GO:0032205)2.80449672
75double-strand break repair via nonhomologous end joining (GO:0006303)2.80433082
76non-recombinational repair (GO:0000726)2.80433082
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79910078
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79910078
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79910078
80termination of RNA polymerase II transcription (GO:0006369)2.78498313
81DNA strand renaturation (GO:0000733)2.78265597
82IMP biosynthetic process (GO:0006188)2.78117245
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76988131
84regulation of mitotic spindle checkpoint (GO:1903504)2.76988131
85positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76667769
86DNA integration (GO:0015074)2.76599987
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76109280
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76109280
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75519443
90isotype switching (GO:0045190)2.75519443
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75519443
92centriole assembly (GO:0098534)2.74969006
93regulation of cellular amino acid metabolic process (GO:0006521)2.74145769
94DNA double-strand break processing (GO:0000729)2.73925471
95meiotic chromosome segregation (GO:0045132)2.73915966
96deoxyribonucleotide biosynthetic process (GO:0009263)2.72082794
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.72029645
98deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71884468
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71560080
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.71539112
101signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71539112
102establishment of integrated proviral latency (GO:0075713)2.71511183
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70656246
104regulation of mitochondrial translation (GO:0070129)2.69694071
105negative regulation of mRNA processing (GO:0050686)2.67977213
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67614549
107inner mitochondrial membrane organization (GO:0007007)2.67543744
108L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67276115
109RNA methylation (GO:0001510)2.66875369
110RNA-dependent DNA replication (GO:0006278)2.66838892
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66273591
112positive regulation of gamma-delta T cell activation (GO:0046645)2.64807653
113protein K6-linked ubiquitination (GO:0085020)2.63624241
114ubiquinone biosynthetic process (GO:0006744)2.63511063
115quinone biosynthetic process (GO:1901663)2.63511063
116telomere maintenance (GO:0000723)2.62901378
117mismatch repair (GO:0006298)2.62845328
118DNA ligation (GO:0006266)2.62721494
119telomere organization (GO:0032200)2.62436877
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62054146
121pseudouridine synthesis (GO:0001522)2.61962443
122transcription from RNA polymerase III promoter (GO:0006383)2.61144059
123postreplication repair (GO:0006301)2.60574456
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59769063
125tRNA aminoacylation for protein translation (GO:0006418)2.59356838
126GPI anchor biosynthetic process (GO:0006506)2.58589113
127reciprocal DNA recombination (GO:0035825)2.56789564
128reciprocal meiotic recombination (GO:0007131)2.56789564
129pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56482744
130regulation of helicase activity (GO:0051095)2.56272010
131DNA damage response, detection of DNA damage (GO:0042769)2.55557878
132replication fork processing (GO:0031297)2.53866273
133telomere maintenance via telomere lengthening (GO:0010833)2.53439068
134rRNA methylation (GO:0031167)2.52648603
135protein deneddylation (GO:0000338)2.52524140
136cullin deneddylation (GO:0010388)2.52496092
137DNA-dependent DNA replication (GO:0006261)2.52276036
138telomere maintenance via semi-conservative replication (GO:0032201)2.49361267
1392-deoxyribonucleotide metabolic process (GO:0009394)2.49144907
140regulation of translation in response to stress (GO:0043555)2.47965412
141methionine biosynthetic process (GO:0009086)2.47411455
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46986809
143viral mRNA export from host cell nucleus (GO:0046784)2.45757796
144poly(A)+ mRNA export from nucleus (GO:0016973)2.45250069
145deoxyribonucleotide catabolic process (GO:0009264)2.44969542
146regulation of T cell mediated cytotoxicity (GO:0001914)2.44260364
147telomere maintenance via telomerase (GO:0007004)2.44107664
148ubiquinone metabolic process (GO:0006743)2.43524706
149spliceosomal snRNP assembly (GO:0000387)2.42546073
150kinetochore assembly (GO:0051382)2.41689985
151deoxyribonucleotide metabolic process (GO:0009262)2.41065890
152GDP-mannose metabolic process (GO:0019673)2.40301113
153guanosine-containing compound biosynthetic process (GO:1901070)2.39255624
154GTP biosynthetic process (GO:0006183)2.38394750
155adenosine metabolic process (GO:0046085)2.38347011
156response to UV-B (GO:0010224)2.37686687
157deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.37584324
158pyrimidine nucleotide catabolic process (GO:0006244)2.37546707
159DNA-templated transcription, termination (GO:0006353)2.36437186
160preassembly of GPI anchor in ER membrane (GO:0016254)2.35519710
161purine deoxyribonucleotide catabolic process (GO:0009155)2.35291775
162methionine metabolic process (GO:0006555)2.35256635
163transcription elongation from RNA polymerase I promoter (GO:0006362)2.34091957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.13757942
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.75764328
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67178656
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62941206
5E2F7_22180533_ChIP-Seq_HELA_Human3.05847653
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.01013015
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.88616146
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85449135
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.82453135
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66414065
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63796348
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61174380
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.56317687
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.53795901
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52352136
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49850045
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49065212
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.45077748
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.43698749
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28922940
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28639450
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.28506028
23FOXP3_21729870_ChIP-Seq_TREG_Human2.27962378
24VDR_23849224_ChIP-Seq_CD4+_Human2.27453115
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.19347872
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16580635
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.13467662
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13235987
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02404199
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01126107
31DCP1A_22483619_ChIP-Seq_HELA_Human2.00771997
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96089162
33ZNF274_21170338_ChIP-Seq_K562_Hela1.87679804
34CIITA_25753668_ChIP-Seq_RAJI_Human1.87046085
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86552772
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86452126
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84703047
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84511467
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80108312
40KDM5A_27292631_Chip-Seq_BREAST_Human1.78480637
41ELK1_19687146_ChIP-ChIP_HELA_Human1.74148880
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72766648
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72743588
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.71050983
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.70035002
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60015655
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59108030
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58727318
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.53314278
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.51759844
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50307925
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47180153
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.46875929
54GABP_19822575_ChIP-Seq_HepG2_Human1.43393257
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43271945
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42904761
57XRN2_22483619_ChIP-Seq_HELA_Human1.41768837
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40467272
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40291391
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39601093
61MYC_18940864_ChIP-ChIP_HL60_Human1.38106943
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36380275
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35552898
64TTF2_22483619_ChIP-Seq_HELA_Human1.33781923
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32240188
66IRF1_19129219_ChIP-ChIP_H3396_Human1.31399167
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31099626
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30628079
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.29996360
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26817389
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25255703
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22990457
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22316358
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20885412
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19573424
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18285228
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18185978
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18185013
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14930090
80SPI1_23547873_ChIP-Seq_NB4_Human1.11722007
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11250958
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10876145
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10742425
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10312476
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.10236979
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08168520
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.07633239
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06768594
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06514500
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04616713
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04579951
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04540752
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03991048
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03206558
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01432364
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99371708
97VDR_22108803_ChIP-Seq_LS180_Human0.98108099
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97940848
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97810047
100P53_22387025_ChIP-Seq_ESCs_Mouse0.96891723
101ZFX_18555785_Chip-Seq_ESCs_Mouse0.95830156
102EZH2_27294783_Chip-Seq_NPCs_Mouse0.94496004
103SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93754002
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.93309596
105GBX2_23144817_ChIP-Seq_PC3_Human0.92162933
106NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90935089
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89838309
108EWS_26573619_Chip-Seq_HEK293_Human0.89075800
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88780106
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88666677
111IGF1R_20145208_ChIP-Seq_DFB_Human0.88629240
112* FOXP1_21924763_ChIP-Seq_HESCs_Human0.87985877
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87724999
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87575001
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87538474
116P300_18555785_Chip-Seq_ESCs_Mouse0.86549678
117SOX2_18555785_Chip-Seq_ESCs_Mouse0.86541674
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86457206
119MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84490954
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84395529
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81846324
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80176539
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79569960
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77827674
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76876106
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75616178
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75339543
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75145772
129TFEB_21752829_ChIP-Seq_HELA_Human0.73216703
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73101358
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.72181856
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70208677
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69842904
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68397831
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67885364
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.67748824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.07464966
2MP0008058_abnormal_DNA_repair2.83815978
3MP0005075_abnormal_melanosome_morpholog2.76697095
4MP0004957_abnormal_blastocyst_morpholog2.57423348
5MP0003787_abnormal_imprinting2.44575610
6MP0008057_abnormal_DNA_replication2.39955483
7MP0003763_abnormal_thymus_physiology2.39399738
8MP0001188_hyperpigmentation2.37245641
9MP0003693_abnormal_embryo_hatching2.29072550
10MP0005671_abnormal_response_to2.27095453
11MP0006072_abnormal_retinal_apoptosis2.17965777
12MP0002396_abnormal_hematopoietic_system2.12852504
13MP0004381_abnormal_hair_follicle2.08137986
14MP0000015_abnormal_ear_pigmentation2.05246587
15MP0001835_abnormal_antigen_presentation2.04619725
16MP0005646_abnormal_pituitary_gland2.04295608
17MP0010386_abnormal_urinary_bladder2.03442956
18MP0006036_abnormal_mitochondrial_physio2.00244023
19MP0008789_abnormal_olfactory_epithelium1.98173256
20MP0009785_altered_susceptibility_to1.97331050
21MP0008995_early_reproductive_senescence1.96558835
22MP0002102_abnormal_ear_morphology1.93067311
23MP0000678_abnormal_parathyroid_gland1.92069302
24MP0008877_abnormal_DNA_methylation1.88785592
25MP0010094_abnormal_chromosome_stability1.88163217
26MP0006035_abnormal_mitochondrial_morpho1.82907983
27MP0002638_abnormal_pupillary_reflex1.82264005
28MP0001529_abnormal_vocalization1.78241686
29MP0005394_taste/olfaction_phenotype1.75406632
30MP0005499_abnormal_olfactory_system1.75406632
31MP0005360_urolithiasis1.74548593
32MP0002132_abnormal_respiratory_system1.72957674
33MP0000566_synostosis1.72179140
34MP0005645_abnormal_hypothalamus_physiol1.70846987
35MP0001986_abnormal_taste_sensitivity1.64829976
36MP0008875_abnormal_xenobiotic_pharmacok1.60430972
37MP0003806_abnormal_nucleotide_metabolis1.59282966
38MP0003121_genomic_imprinting1.58899154
39MP0001293_anophthalmia1.55098007
40MP0002163_abnormal_gland_morphology1.52233908
41MP0002277_abnormal_respiratory_mucosa1.51751016
42MP0003111_abnormal_nucleus_morphology1.51620287
43MP0008007_abnormal_cellular_replicative1.50205698
44MP0002148_abnormal_hypersensitivity_rea1.47527324
45MP0005174_abnormal_tail_pigmentation1.47450876
46MP0001800_abnormal_humoral_immune1.46508205
47MP0002138_abnormal_hepatobiliary_system1.43093439
48MP0009333_abnormal_splenocyte_physiolog1.40141456
49MP0000685_abnormal_immune_system1.40108553
50MP0003077_abnormal_cell_cycle1.38993678
51MP0001790_abnormal_immune_system1.38785004
52MP0005387_immune_system_phenotype1.38785004
53MP0006276_abnormal_autonomic_nervous1.37164180
54MP0009697_abnormal_copulation1.35318819
55MP0002420_abnormal_adaptive_immunity1.34982170
56MP0001819_abnormal_immune_cell1.34785979
57MP0005025_abnormal_response_to1.33050694
58MP0002723_abnormal_immune_serum1.31581293
59MP0002398_abnormal_bone_marrow1.30687293
60MP0008260_abnormal_autophagy1.29977126
61MP0003315_abnormal_perineum_morphology1.29806332
62MP0002452_abnormal_antigen_presenting1.28222038
63MP0001929_abnormal_gametogenesis1.26326899
64MP0000490_abnormal_crypts_of1.25938920
65MP0002837_dystrophic_cardiac_calcinosis1.21871629
66MP0002095_abnormal_skin_pigmentation1.21200692
67MP0002938_white_spotting1.19161539
68MP0005253_abnormal_eye_physiology1.17291646
69MP0001764_abnormal_homeostasis1.17083453
70MP0000716_abnormal_immune_system1.16338169
71MP0005000_abnormal_immune_tolerance1.15571775
72MP0005379_endocrine/exocrine_gland_phen1.15379477
73MP0002210_abnormal_sex_determination1.15343557
74MP0000703_abnormal_thymus_morphology1.10035301
75MP0001984_abnormal_olfaction1.09712412
76MP0003786_premature_aging1.07671150
77MP0003718_maternal_effect1.06404495
78MP0000372_irregular_coat_pigmentation1.06096739
79MP0000026_abnormal_inner_ear1.04619023
80MP0004147_increased_porphyrin_level1.04586838
81MP0000689_abnormal_spleen_morphology1.04172383
82MP0004133_heterotaxia1.02838769
83MP0003183_abnormal_peptide_metabolism1.01816622
84MP0005551_abnormal_eye_electrophysiolog1.01658068
85MP0005220_abnormal_exocrine_pancreas1.01443968
86MP0003136_yellow_coat_color1.00914379
87MP0002722_abnormal_immune_system1.00418842
88MP0005408_hypopigmentation0.99856841
89MP0002139_abnormal_hepatobiliary_system0.99160220
90MP0002876_abnormal_thyroid_physiology0.99107750
91MP0002429_abnormal_blood_cell0.98722582
92MP0000358_abnormal_cell_content/0.98432790
93MP0001145_abnormal_male_reproductive0.98376721
94MP0000631_abnormal_neuroendocrine_gland0.98335406
95MP0002019_abnormal_tumor_incidence0.97234065
96MP0005084_abnormal_gallbladder_morpholo0.96702063
97MP0002254_reproductive_system_inflammat0.96203299
98MP0003122_maternal_imprinting0.95088028
99MP0000653_abnormal_sex_gland0.95067650
100MP0003698_abnormal_male_reproductive0.94653020
101MP0003186_abnormal_redox_activity0.94549744
102MP0002419_abnormal_innate_immunity0.93651508
103MP0001486_abnormal_startle_reflex0.93049809
104MP0003195_calcinosis0.92804792
105MP0000049_abnormal_middle_ear0.92305624
106MP0001119_abnormal_female_reproductive0.90920611
107MP0002653_abnormal_ependyma_morphology0.90367631
108MP0001661_extended_life_span0.90001088
109MP0001186_pigmentation_phenotype0.88893870
110MP0001346_abnormal_lacrimal_gland0.88548644
111MP0002693_abnormal_pancreas_physiology0.86608259
112MP0003724_increased_susceptibility_to0.85984202
113MP0001730_embryonic_growth_arrest0.85499595
114MP0002751_abnormal_autonomic_nervous0.84883366
115MP0000569_abnormal_digit_pigmentation0.84359811
116MP0004782_abnormal_surfactant_physiolog0.84199760
117MP0002233_abnormal_nose_morphology0.83200988
118MP0004142_abnormal_muscle_tone0.81524117
119MP0005410_abnormal_fertilization0.80510245
120MP0002234_abnormal_pharynx_morphology0.80416123
121MP0000371_diluted_coat_color0.80241664
122MP0003943_abnormal_hepatobiliary_system0.79766939
123MP0005391_vision/eye_phenotype0.78878536
124MP0000778_abnormal_nervous_system0.78747723
125MP0008932_abnormal_embryonic_tissue0.78221946
126MP0001697_abnormal_embryo_size0.77817107
127MP0005423_abnormal_somatic_nervous0.77719994
128MP0010155_abnormal_intestine_physiology0.77186561
129MP0001873_stomach_inflammation0.76645963
130MP0000681_abnormal_thyroid_gland0.75844604
131MP0001905_abnormal_dopamine_level0.74187081
132MP0002177_abnormal_outer_ear0.74186651
133MP0001919_abnormal_reproductive_system0.74058334
134MP0008872_abnormal_physiological_respon0.73921256
135MP0003646_muscle_fatigue0.73838561
136MP0000313_abnormal_cell_death0.73204114
137MP0002405_respiratory_system_inflammati0.70790370
138MP0000538_abnormal_urinary_bladder0.70424858
139MP0005266_abnormal_metabolism0.70121772
140MP0002160_abnormal_reproductive_system0.70090349
141MP0000350_abnormal_cell_proliferation0.69756137
142MP0005332_abnormal_amino_acid0.68680598
143MP0001270_distended_abdomen0.68462418
144MP0005380_embryogenesis_phenotype0.67861759
145MP0001672_abnormal_embryogenesis/_devel0.67861759
146MP0005365_abnormal_bile_salt0.66422284
147MP0005389_reproductive_system_phenotype0.66132224
148MP0004742_abnormal_vestibular_system0.65472820
149MP0002080_prenatal_lethality0.62960930
150MP0002166_altered_tumor_susceptibility0.62916182

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)3.95802894
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62568546
3Abnormality of the preputium (HP:0100587)3.33045954
4Chromsome breakage (HP:0040012)3.23779347
5Reduced antithrombin III activity (HP:0001976)3.20543170
6Bile duct proliferation (HP:0001408)3.17123749
7Abnormal biliary tract physiology (HP:0012439)3.17123749
8Abnormal protein glycosylation (HP:0012346)3.11251005
9Abnormal glycosylation (HP:0012345)3.11251005
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.11251005
11Abnormal protein N-linked glycosylation (HP:0012347)3.11251005
12Abnormality of the renal collecting system (HP:0004742)3.09055500
13Chronic hepatic failure (HP:0100626)2.89795138
14Aplastic anemia (HP:0001915)2.79351319
15Severe visual impairment (HP:0001141)2.76057997
16Abnormality of the ileum (HP:0001549)2.72338754
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.70736933
18Optic nerve coloboma (HP:0000588)2.68745403
19Birth length less than 3rd percentile (HP:0003561)2.67740223
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67117095
21Mitochondrial inheritance (HP:0001427)2.66525773
22Acute necrotizing encephalopathy (HP:0006965)2.66276461
23Type 2 muscle fiber atrophy (HP:0003554)2.63679987
24Meckel diverticulum (HP:0002245)2.62737933
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57805195
26True hermaphroditism (HP:0010459)2.56631622
27Abnormal mitochondria in muscle tissue (HP:0008316)2.49525795
28Protruding tongue (HP:0010808)2.49303055
29Increased muscle lipid content (HP:0009058)2.46866763
30Colon cancer (HP:0003003)2.46092611
31Abnormality of glycolysis (HP:0004366)2.45006620
32Clubbing of toes (HP:0100760)2.44085098
33Abnormality of the labia minora (HP:0012880)2.42769069
34Increased hepatocellular lipid droplets (HP:0006565)2.42744562
35Hypothermia (HP:0002045)2.42371531
36Abnormality of cells of the erythroid lineage (HP:0012130)2.41530070
37Increased CSF lactate (HP:0002490)2.36778159
38IgM deficiency (HP:0002850)2.36392787
39Abnormality of chromosome stability (HP:0003220)2.34044873
40Bone marrow hypocellularity (HP:0005528)2.31422591
41Pancreatic fibrosis (HP:0100732)2.29476787
42Reticulocytopenia (HP:0001896)2.28828095
43Hepatocellular necrosis (HP:0001404)2.28156108
44Squamous cell carcinoma (HP:0002860)2.26857259
45Duplicated collecting system (HP:0000081)2.25229829
46Horseshoe kidney (HP:0000085)2.24890333
47Renal Fanconi syndrome (HP:0001994)2.22359301
48Sloping forehead (HP:0000340)2.22001285
49Absent thumb (HP:0009777)2.21172056
50Muscle fiber atrophy (HP:0100295)2.20060915
51Abnormal hair whorl (HP:0010721)2.19976798
52Increased serum pyruvate (HP:0003542)2.19456320
53Ependymoma (HP:0002888)2.19385357
54Hyperglycinemia (HP:0002154)2.18858781
55Myelodysplasia (HP:0002863)2.16746362
56Abnormality of DNA repair (HP:0003254)2.16021883
57Pancytopenia (HP:0001876)2.11672618
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11656306
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11656306
60Molar tooth sign on MRI (HP:0002419)2.10808930
61Abnormality of midbrain morphology (HP:0002418)2.10808930
62Microvesicular hepatic steatosis (HP:0001414)2.10521336
633-Methylglutaconic aciduria (HP:0003535)2.10374872
64Increased serum lactate (HP:0002151)2.09768461
65Lipid accumulation in hepatocytes (HP:0006561)2.09538343
66Methylmalonic aciduria (HP:0012120)2.09393185
67Exertional dyspnea (HP:0002875)2.08831444
68Intestinal atresia (HP:0011100)2.07489176
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06205977
70Dicarboxylic aciduria (HP:0003215)2.06205977
71Oral leukoplakia (HP:0002745)2.05701559
72Nephrogenic diabetes insipidus (HP:0009806)2.04517948
73Cerebral edema (HP:0002181)2.03007089
74Renal cortical cysts (HP:0000803)1.99967135
75Abnormality of alanine metabolism (HP:0010916)1.98419895
76Hyperalaninemia (HP:0003348)1.98419895
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98419895
78Acute encephalopathy (HP:0006846)1.98311460
79Hepatic necrosis (HP:0002605)1.96595436
80Pancreatic cysts (HP:0001737)1.96083794
81Panhypogammaglobulinemia (HP:0003139)1.96034473
82Medial flaring of the eyebrow (HP:0010747)1.95761355
83Acute lymphatic leukemia (HP:0006721)1.95004430
84Methylmalonic acidemia (HP:0002912)1.94794485
85Abnormal rod and cone electroretinograms (HP:0008323)1.93915019
86Combined immunodeficiency (HP:0005387)1.93765917
87Split foot (HP:0001839)1.93423076
88Retinal dysplasia (HP:0007973)1.92091224
89Cerebral hypomyelination (HP:0006808)1.91725182
90Respiratory difficulties (HP:0002880)1.91645538
91Conjugated hyperbilirubinemia (HP:0002908)1.90983885
92Exercise intolerance (HP:0003546)1.89826433
93IgG deficiency (HP:0004315)1.88283544
94Abnormality of serine family amino acid metabolism (HP:0010894)1.86531944
95Abnormality of glycine metabolism (HP:0010895)1.86531944
96Hyperglycinuria (HP:0003108)1.85894417
97Abnormal number of incisors (HP:0011064)1.85550295
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85535388
99Ectopic kidney (HP:0000086)1.84460288
100Nasolacrimal duct obstruction (HP:0000579)1.83860172
101Type II lissencephaly (HP:0007260)1.82485218
102Mediastinal lymphadenopathy (HP:0100721)1.82355298
103Premature ovarian failure (HP:0008209)1.82192285
104Emotional lability (HP:0000712)1.81987900
105Progressive macrocephaly (HP:0004481)1.81777187
106Septo-optic dysplasia (HP:0100842)1.81326034
107Abnormality of the carotid arteries (HP:0005344)1.81110644
108Irregular epiphyses (HP:0010582)1.80749749
109Severe combined immunodeficiency (HP:0004430)1.80690612
110Abnormality of T cell physiology (HP:0011840)1.80464152
111Duodenal stenosis (HP:0100867)1.79621746
112Small intestinal stenosis (HP:0012848)1.79621746
113Lactic acidosis (HP:0003128)1.79620791
114Febrile seizures (HP:0002373)1.79539792
115Progressive microcephaly (HP:0000253)1.79370339
116Abnormality of B cell number (HP:0010975)1.78830838
117B lymphocytopenia (HP:0010976)1.78830838
118Triphalangeal thumb (HP:0001199)1.78747354
119Hypoplasia of the fovea (HP:0007750)1.78564355
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.78564355
121Lymphoma (HP:0002665)1.78480056
122Preaxial hand polydactyly (HP:0001177)1.78253590
123Chronic otitis media (HP:0000389)1.77435599
124Patellar aplasia (HP:0006443)1.77144042
125Neutropenia (HP:0001875)1.77094564
126Lip pit (HP:0100267)1.76947308
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76771358
128Abnormality of the duodenum (HP:0002246)1.76694007
129Lethargy (HP:0001254)1.76597213
130Pancreatic islet-cell hyperplasia (HP:0004510)1.75925054
131Abnormality of serum amino acid levels (HP:0003112)1.75417827
132CNS demyelination (HP:0007305)1.75077295
133Hypoplasia of the pons (HP:0012110)1.73986954
134Chronic mucocutaneous candidiasis (HP:0002728)1.73573227
135Recurrent cutaneous fungal infections (HP:0011370)1.73573227
136Congenital primary aphakia (HP:0007707)1.70857571
137Decreased circulating renin level (HP:0003351)1.70151933
138Increased intramyocellular lipid droplets (HP:0012240)1.69895467
139Gait imbalance (HP:0002141)1.69624232
140Chronic sinusitis (HP:0011109)1.68749260
141Abnormality of the prostate (HP:0008775)1.68204974
142Poor suck (HP:0002033)1.67936076
143Thrombocytosis (HP:0001894)1.66947626
144Abnormal number of erythroid precursors (HP:0012131)1.65739297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.11478587
2PASK3.77794961
3MAP4K23.73227766
4VRK23.21150308
5SIK32.80112345
6MAP2K72.61425488
7TXK2.60587918
8CDC72.59778275
9IRAK42.44923672
10IRAK32.40555012
11PRPF4B2.38696718
12TRIM282.34306621
13SRPK12.33728870
14VRK12.30412506
15EIF2AK12.19447078
16TNK22.05461982
17ZAK2.01243247
18CASK2.00171596
19EIF2AK21.91993529
20YES11.87804929
21MAP3K141.83882929
22NEK11.81094980
23TNIK1.80799500
24NME21.66014147
25TAOK21.65335383
26AKT31.65029532
27EIF2AK31.64625974
28MAP4K11.55981217
29TEC1.55906908
30TLK11.50212955
31MKNK21.49953497
32KIT1.46262081
33WNK31.44658465
34PLK41.43187413
35BUB11.43152904
36CSNK1G31.39523929
37MAPK131.34869788
38MARK31.34458012
39RPS6KA41.31572445
40ADRBK21.31183113
41BMPR21.30994789
42BRSK21.29948226
43CSNK1G11.29248537
44CSNK1A1L1.28766778
45BTK1.25958529
46IKBKE1.24899279
47MKNK11.24286382
48TSSK61.22410239
49MST41.21302791
50PDK21.20635750
51BMPR1B1.14657173
52ERBB31.14570673
53INSRR1.13849908
54FRK1.12441742
55BRD41.11240334
56TGFBR11.08364160
57ACVR1B1.08344533
58FLT31.07069283
59MAP3K121.06003141
60MAP3K41.04505847
61IRAK11.03801578
62WEE11.02778326
63IKBKB1.02167138
64NME11.01618505
65NEK20.99422853
66STK38L0.98737799
67AURKB0.96883843
68CHEK20.93350031
69SGK20.92815110
70BRSK10.92643702
71MUSK0.90127994
72CSNK1G20.89045171
73ATR0.87664649
74BCKDK0.87422299
75TAF10.85638772
76DYRK20.82481467
77RPS6KA50.82276717
78STK240.82046124
79TAOK30.79024162
80CCNB10.78440423
81CHEK10.75651495
82SYK0.75572597
83IRAK20.74386738
84CDK40.71965551
85PIM20.71527978
86PINK10.70282869
87TESK20.69984285
88MAPK110.67552871
89JAK30.67410593
90MAPKAPK30.67254933
91CDK30.67125521
92DAPK10.67059688
93LYN0.66457673
94NEK60.65836264
95MAPK70.65665887
96PLK10.61388069
97CSNK2A20.60121991
98KDR0.59771032
99ZAP700.58347418
100GRK10.57503651
101DYRK1A0.56263314
102CDK80.55799237
103RPS6KC10.54330425
104RPS6KL10.54330425
105RPS6KA60.53771782
106RAF10.52958050
107LCK0.52918522
108PBK0.52630930
109PLK30.52505918
110PRKCI0.52274314
111BCR0.49184246
112AURKA0.48971581
113CSNK1A10.48955551
114BRAF0.48856111
115MAP2K60.48427706
116CDK90.46867068
117TBK10.46592087
118CSF1R0.46576650
119DYRK30.46389707
120BLK0.45650552
121CHUK0.45609707
122CDK10.45563546
123TYK20.45554315
124MARK10.45020045
125ITK0.44037841
126RPS6KB20.43666541
127WNK40.42860331
128SIK20.42828286
129GRK70.42392019
130MAPK150.41826967
131TTK0.41704911
132PRKCQ0.41483656
133PIM10.41026994
134MYLK0.40686067
135CDK20.39105909
136RPS6KB10.38132492
137MAPKAPK50.37662949
138GRK60.36672809
139CSNK2A10.36459045
140ATM0.31079700
141PRKDC0.29847650
142CLK10.29446890
143TIE10.28642807
144MAPK40.28160045
145NUAK10.27763598
146CDK70.27586298
147CAMK10.27012965

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.36044499
2Homologous recombination_Homo sapiens_hsa034403.12687949
3Ribosome_Homo sapiens_hsa030102.85606005
4Proteasome_Homo sapiens_hsa030502.83426413
5Fanconi anemia pathway_Homo sapiens_hsa034602.80707801
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.80046702
7Mismatch repair_Homo sapiens_hsa034302.75833789
8DNA replication_Homo sapiens_hsa030302.62804917
9Pyrimidine metabolism_Homo sapiens_hsa002402.61801048
10Base excision repair_Homo sapiens_hsa034102.58033715
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42417540
12Spliceosome_Homo sapiens_hsa030402.39774865
13Non-homologous end-joining_Homo sapiens_hsa034502.39640835
14Protein export_Homo sapiens_hsa030602.28334323
15Primary immunodeficiency_Homo sapiens_hsa053402.26563988
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92175810
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75155273
18Basal transcription factors_Homo sapiens_hsa030221.74129924
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71319757
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65922833
21Propanoate metabolism_Homo sapiens_hsa006401.64496461
22RNA degradation_Homo sapiens_hsa030181.60982669
23One carbon pool by folate_Homo sapiens_hsa006701.60784979
24Purine metabolism_Homo sapiens_hsa002301.57395534
25Oxidative phosphorylation_Homo sapiens_hsa001901.52551911
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.52525613
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.51992426
28Allograft rejection_Homo sapiens_hsa053301.51925238
29Nucleotide excision repair_Homo sapiens_hsa034201.47959176
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44650431
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.44551990
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44160595
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43254497
34Parkinsons disease_Homo sapiens_hsa050121.37951515
35Nicotine addiction_Homo sapiens_hsa050331.37696200
36Herpes simplex infection_Homo sapiens_hsa051681.33635502
37Measles_Homo sapiens_hsa051621.28781583
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28134234
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27965013
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27691649
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26495307
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26240480
43RNA transport_Homo sapiens_hsa030131.25649439
44Steroid biosynthesis_Homo sapiens_hsa001001.23819178
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23213709
46Pyruvate metabolism_Homo sapiens_hsa006201.23139543
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.22104890
48Graft-versus-host disease_Homo sapiens_hsa053321.19223766
49N-Glycan biosynthesis_Homo sapiens_hsa005101.18563290
50Huntingtons disease_Homo sapiens_hsa050161.18451221
51Selenocompound metabolism_Homo sapiens_hsa004501.16907788
52Butanoate metabolism_Homo sapiens_hsa006501.16805963
53Epstein-Barr virus infection_Homo sapiens_hsa051691.08955065
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08424263
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.07771108
56mRNA surveillance pathway_Homo sapiens_hsa030151.03100049
57Hematopoietic cell lineage_Homo sapiens_hsa046401.02763171
58Type I diabetes mellitus_Homo sapiens_hsa049401.02085685
59Biosynthesis of amino acids_Homo sapiens_hsa012301.01991896
60Carbon metabolism_Homo sapiens_hsa012001.00939456
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97519863
62Alzheimers disease_Homo sapiens_hsa050100.93793792
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92971403
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92488100
65Peroxisome_Homo sapiens_hsa041460.89772005
66Legionellosis_Homo sapiens_hsa051340.89274516
67Regulation of autophagy_Homo sapiens_hsa041400.89221832
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88042350
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86521045
70Autoimmune thyroid disease_Homo sapiens_hsa053200.86518584
71p53 signaling pathway_Homo sapiens_hsa041150.85904952
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85903689
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85535410
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.85436509
75Influenza A_Homo sapiens_hsa051640.81750162
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79834373
77Phototransduction_Homo sapiens_hsa047440.79624131
78Caffeine metabolism_Homo sapiens_hsa002320.78915992
79Cell cycle_Homo sapiens_hsa041100.78719131
80Fatty acid degradation_Homo sapiens_hsa000710.76754191
81Fatty acid metabolism_Homo sapiens_hsa012120.76579896
82Glutathione metabolism_Homo sapiens_hsa004800.76035171
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72919237
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72677683
85Taste transduction_Homo sapiens_hsa047420.70560953
86Leishmaniasis_Homo sapiens_hsa051400.70462291
87Other glycan degradation_Homo sapiens_hsa005110.70350665
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69443811
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68240709
90Tryptophan metabolism_Homo sapiens_hsa003800.67354963
91Systemic lupus erythematosus_Homo sapiens_hsa053220.65912765
92Linoleic acid metabolism_Homo sapiens_hsa005910.65326491
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64301730
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63697266
95Fat digestion and absorption_Homo sapiens_hsa049750.63601405
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62720375
97Rheumatoid arthritis_Homo sapiens_hsa053230.60202485
98Notch signaling pathway_Homo sapiens_hsa043300.60155551
99Nitrogen metabolism_Homo sapiens_hsa009100.57017426
100Chemical carcinogenesis_Homo sapiens_hsa052040.55567097
101Antigen processing and presentation_Homo sapiens_hsa046120.54168001
102T cell receptor signaling pathway_Homo sapiens_hsa046600.53966127
103Arachidonic acid metabolism_Homo sapiens_hsa005900.53549448
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52764020
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52561370
106Metabolic pathways_Homo sapiens_hsa011000.48677704
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.48183142
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44901856
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44643595
110Arginine and proline metabolism_Homo sapiens_hsa003300.42288625
111Folate biosynthesis_Homo sapiens_hsa007900.41562141
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41035951
113Fructose and mannose metabolism_Homo sapiens_hsa000510.40265934
114Lysine degradation_Homo sapiens_hsa003100.39994838
115Retinol metabolism_Homo sapiens_hsa008300.39465298
116Ether lipid metabolism_Homo sapiens_hsa005650.39418298
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38688389
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38191516
119Morphine addiction_Homo sapiens_hsa050320.37621606
120Oocyte meiosis_Homo sapiens_hsa041140.37210023
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36904514
122Asthma_Homo sapiens_hsa053100.35729844
123Sphingolipid metabolism_Homo sapiens_hsa006000.34912436
124Pertussis_Homo sapiens_hsa051330.34478964
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32220942
126Sulfur relay system_Homo sapiens_hsa041220.31130728
127Hepatitis B_Homo sapiens_hsa051610.31112681
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30207392
129Tyrosine metabolism_Homo sapiens_hsa003500.30078663
130HTLV-I infection_Homo sapiens_hsa051660.28073896
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26407395
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26178943
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.25519025
134beta-Alanine metabolism_Homo sapiens_hsa004100.24706933
135Apoptosis_Homo sapiens_hsa042100.24229347
136Serotonergic synapse_Homo sapiens_hsa047260.24224987
137African trypanosomiasis_Homo sapiens_hsa051430.23775081
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23286009
139Tuberculosis_Homo sapiens_hsa051520.22366305
140Vitamin digestion and absorption_Homo sapiens_hsa049770.22194009
141TNF signaling pathway_Homo sapiens_hsa046680.18985510
142Fatty acid elongation_Homo sapiens_hsa000620.18850707
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14288889
144B cell receptor signaling pathway_Homo sapiens_hsa046620.13764565

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